Role of Pharmacogenomics in Drug Development – An Industry ...
Role of Pharmacogenomics in Drug Development – An Industry ...
Role of Pharmacogenomics in Drug Development – An Industry ...
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PGx reveals efficacy for rosiglitazone <strong>in</strong>Alzheimer’s Disease (AD)• PPARγ agonist approved for the treatment <strong>of</strong> Type 2 Diabetes• Rationale <strong>in</strong> AD<strong>–</strong> Decl<strong>in</strong>e <strong>in</strong> cerebral glucose utilisation l<strong>in</strong>ked to AD progression<strong>–</strong> PPARγ agonists may <strong>in</strong>crease glucose bra<strong>in</strong> entry and utilization<strong>–</strong> Positive cognitive effect <strong>in</strong> pilot study (n=30)• Phase II, 24 week placebo controlled, dose rang<strong>in</strong>g study <strong>of</strong> rosiglitazoneefficacy <strong>in</strong> mild to moderate AD patients• DNA samples collected for PGx analysis <strong>of</strong> rosiglitazone response follow<strong>in</strong>gstratification <strong>of</strong> APOE4 carriage<strong>–</strong> APOE ε4 positive & APOE ε4 negative• Cl<strong>in</strong>ical study results published<strong>–</strong> Risner et al, <strong>Pharmacogenomics</strong> Journal, 2006; doi:1038/sj.tpj.6500369
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