Role of Pharmacogenomics in Drug Development – An Industry ...

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New Medicines Are Increasingly MoreExpensive To Develop1970’s1980’s1990’s$138m$318m$800m - Duration 15Yr• Need to reduce Pipeline Attrition– >70% of cost is allocated to failures–
Variation in medicine response to can beclassified by Pharmacogenetics• Pharmacogenetics (PGx) is the study of how drugresponse varies in individuals, due to differences intheir DNA• Variation includes differences in pharmacokinetics,efficacy, safety and/or tolerability• PGx does not change how a person will respond to amedicine• PGx is a tool that can be used to identify patients whowill have the desired response (efficacy & safety)
Page 1: Role of Pharmacogenomics inDrug Dev
Page 5 and 6: GSK Pharmacogenetic StrategyOngoing
Page 7 and 8: Efficacy PGx: Opportunities• Asso
Page 9 and 10: APOE4 - a susceptibility gene varia
Page 11 and 12: ADAS-Cog Score in APOE ε4-Negative
Page 13 and 14: Rosiglitazone in ADPhase III progre
Page 15 and 16: Abacavir and Hypersensitivity (HSR)
Page 17 and 18: Abacavir HSR Prospective PGx study
Page 19 and 20: PPARγ agonist FarglitazarOedema AE
Page 21 and 22: Farglitazar oedema AE PGxSCNN1B Gen
Page 23 and 24: Ethical considerations• PGx is no

Role of Pharmacogenomics in Drug Development – An Industry ...

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