Role of Pharmacogenomics in Drug Development – An Industry ...
Role of Pharmacogenomics in Drug Development – An Industry ...
Role of Pharmacogenomics in Drug Development – An Industry ...
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Change from Basel<strong>in</strong>e <strong>in</strong> ADAS-CogTotal Scores <strong>in</strong> the ITT PopulationMean Change <strong>in</strong> ADAS-Cog Score-2.5-2-1.5-1-0.500.511.5Cl<strong>in</strong>icalimprovementCl<strong>in</strong>ical decl<strong>in</strong>eBasel<strong>in</strong>e Week 8 Week 16 Week 24RSG 8mg RSG 4mg RSG 2mg PlaceboTreatment differences between rosiglitazone and placebo for ADAS-Cog total scores did not reach statisticalsignificance at Week 24 LOCF. Adapted from The <strong>Pharmacogenomics</strong> Journal 2006, onl<strong>in</strong>e publication, 31January 2006; doi:10.1038/sj.tpj.6500369.
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