Ontology engineering

More documents

Recommendations

Info

in this issue© 2010 Nature America, Inc. All rights reserved.Linking antibody half-life to efficacyMutations that improve the affinity of antibodies for the neonatalFc receptor (FcRn) are known to enhance antibody longevityin vivo. Nonetheless, it has never been demonstrated that prolongedPatent roundupBringing a five-year patent dispute to an end, a federal court inBoston has ruled that Roche’s Mircera (methoxy polyethyleneglycolepoetin beta) does, indeed, infringe on Amgen’s patentsand slapped the Swiss drugmaker with a permanent injunctionbanning sales in the US market. Roche has agreed to a limitedlicense agreement with Amgen that will allow it to sell Mircera inthe US until 2014. [News, p. 112]LMTo solve the conflict between free access to scientific discoveryand intellectual property rights, Bentwich proposes a provisionalpatented paper application procedure that could promote earlierdisclosure of novel scientific knowledge and justify the requirementto grant inexpensive licenses for using inventions for theadvancement of other research. [Patent Article, p. 137] MFRecent patent applications in antibody fragments.[New patents, p. 141]MFexposure to Fc-engineered therapeutic antibodies necessarilyenhances in vivo activity. Desjarlais and colleagues use cynomolgusmonkeys and a humanized transgenic mouse model to show that thereduction in antibody clearance caused by increased antibody affinityfor FcRn enhances the antitumor activities of antibodies targetedagainst either an internalizing surface receptor (epidermal growthfactor receptor) or a cytokine (vascular endothelial growth factor).The enhanced pharmacokinetics associated with Fc-engineered variantsmay translate to greater convenience for patients, reduced costsand higher efficacy. [Brief Communications, p. 157] PHNext month in• Screening for drugs that reconfigure metabolism• Leukemia stem cell quiescence and resistance tochemotherapy• Directed evolution of an MRI contrast agent fordopamine• Autophagy harnessed to clear mutant huntingtinproteinvivolume 28 number 2 february 2010 nature biotechnology
© 2010 Nature America, Inc. All rights reserved.www.nature.com/naturebiotechnologyEDITORIAL OFFICEbiotech@us.nature.com75 Varick Street, Fl 9, New York, NY 10013-1917Tel: (212) 726 9200, Fax: (212) 696 9635Chief Editor: Andrew MarshallSenior Editors: Laura DeFrancesco (News & Features), Kathy Aschheim (Research),Peter Hare (Research), Michael Francisco (Resources and Special Projects)Business Editor: Brady HuggettAssociate Business Editor: Victor BethencourtNews Editor: Lisa MeltonAssociate Editors: Markus Elsner (Research), Craig Mak (Research)Editor-at-Large: John HodgsonContributing Editors: Mark Ratner, Chris ScottContributing Writer: Jeffrey L. FoxSenior Copy Editor: Teresa MooganManaging Production Editor: Ingrid McNamaraSenior Production Editor: Brandy CafarellaProduction Editor: Amanda CrawfordSenior Illustrator: Katie VicariIllustrator/Cover Design: Kimberly CaesarSenior Editorial Assistant: Ania LevinsonMANAGEMENT OFFICESNPG New York75 Varick Street, Fl 9, New York, NY 10013-1917Tel: (212) 726 9200, Fax: (212) 696 9006Publisher: Melanie BrazilExecutive Editor: Linda MillerChief Technology Officer: Howard RatnerHead of Nature Research & Reviews Marketing: Sara GirardCirculation Manager: Stacey NelsonProduction Coordinator: Diane TempranoHead of Web Services: Anthony BarreraSenior Web Production Editor: Laura GogginNPG LondonThe Macmillan Building, 4 Crinan Street, London N1 9XWTel: 44 207 833 4000, Fax: 44 207 843 4996Managing Director: Steven InchcoombePublishing Director: Peter CollinsEditor-in-Chief, Nature Publications: Philip CampbellMarketing Director: Della SarDirector of Web Publishing: Timo HannayNPG Nature Asia-PacificChiyoda Building, 2-37 Ichigayatamachi, Shinjuku-ku, Tokyo 162-0843Tel: 81 3 3267 8751, Fax: 81 3 3267 8746Publishing Director — Asia-Pacific: David SwinbanksAssociate Director: Antoine E. BocquetManager: Koichi NakamuraOperations Director: Hiroshi MinemuraMarketing Manager: Masahiro YamashitaAsia-Pacific Sales Director: Kate YoneyamaAsia-Pacific Sales Manager: Ken MikamiDISPLAY ADVERTISINGdisplay@us.nature.com (US/Canada)display@nature.com (Europe)nature@natureasia.com (Asia)Global Head of Advertising and Sponsorship: Dean Sanderson, Tel: (212) 726 9350,Fax: (212) 696 9482Global Head of Display Advertising: Andrew Douglas, Tel: 44 207 843 4975, Fax: 44 207 843 4996Asia-Pacific Sales Director: Kate Yoneyama, Tel: 81 3 3267 8765, Fax: 81 3 3267 8746Display Account Managers:Global Account Development Manager: Graham Combe, Tel: 44 207 843 4914, Fax: 44 207 843 4749New England: Sheila Reardon, Tel: (617) 399 4098, Fax: (617) 426 3717New York/Mid-Atlantic/Southeast: Jim Breault, Tel: (212) 726 9334, Fax: (212) 696 9481Midwest: Mike Rossi, Tel: (212) 726 9255, Fax: (212) 696 9481West Coast South: George Lui, Tel: (415) 781 3804, Fax: (415) 781 3805West Coast North: Bruce Shaver, Tel: (415) 781 6422, Fax: (415) 781 3805Germany/Switzerland/Austria: Sabine Hugi-Fürst, Tel: 41 52761 3386, Fax: 41 52761 3419United Kingdom/Ireland: Jeremy Betts, Tel: 44 207 843 4968, Fax: 44 207 843 4749Scandinavia/Iceland/Spain/Portugal: Evelina Rubio-Hakansson, Tel: 44 207 843 4079,Fax: 44 207 843 4749France/Belgium/The Netherlands/Italy/Israel/Eastern Europe: Nicola Wright, Tel: 44 207 8434959, Fax: 44 207 843 4749Asia-Pacific Sales Manager: Ken Mikami, Tel: 81 3 3267 8765, Fax: 81 3 3267 8746Greater China/Singapore: Gloria To, Tel: 852 2811 7191, Fax: 852 2811 0743NATUREJOBSnaturejobs@us.nature.com (US/Canada)naturejobs@nature.com (Europe)nature@natureasia.com (Asia)US Sales Manager: Ken Finnegan, Tel: (212) 726 9248, Fax: (212) 696 9482European Sales Manager: Dan Churchward, Tel: 44 207 843 4966, Fax: 44 207 843 4596Asia-Pacific Sales Manager: Ayako Watanabe, Tel: 81 3 3267 8765, Fax: 81 3 3267 8746SITE LICENSE BUSINESS UNITAmericas: Tel: (888) 331 6288institutions@us.nature.comAsia/Pacific: Tel: 81 3 3267 8751institutions@natureasia.comAustralia/New Zealand: Tel: 61 3 9825 1160nature@macmillan.com.auIndia: Tel: 91 124 2881054/55npgindia@nature.comROW: Tel: 44 207 843 4759institutions@nature.comCUSTOMER SERVICEwww.nature.com/helpSenior Global Customer Service Manager: Gerald CoppinFor all print and online assistance, please visit www.nature.com/helpPurchase subscriptions:Americas: Nature Biotechnology, Subscription Dept., 342 Broadway, PMB 301, New York, NY10013-3910, USA. Tel: (866) 363 7860, Fax: (212) 334 0879Europe/ROW: Nature Biotechnology, Subscription Dept., Macmillan Magazines Ltd., Brunel Road,Houndmills, Basingstoke RG21 6XS, United Kingdom. Tel: 44 1256 329 242, Fax: 44 1256 812 358Asia-Pacific: Nature Biotechnology, NPG Nature Asia-Pacific, Chiyoda Building,2-37 Ichigayatamachi, Shinjuku-ku, Tokyo 162-0843. Tel: 81 3 3267 8751, Fax: 81 3 3267 8746India: Nature Biotechnology, NPG India, 3A, 4th Floor, DLF Corporate Park, Gurgaon 122002,India. Tel: 91 124 2881054/55, Tel/Fax: 91 124 2881052REPRINTSreprint@boston.nature.comNature Biotechnology, Reprint Department, Nature Publishing Group, 75 Varick Street, Fl 9,New York, NY 10013-1917, USA.For commercial reprint orders of 600 or more, please contact:UK Reprints: Tel: 44 1256 302 923, Fax: 44 1256 321 531US Reprints: Tel: (617) 494 4900, Fax: (617) 494 4960
Page 3 and 4: volume 28 number 2 february 2010COM
Page 5: in this issue© 2010 Nature America
Page 10 and 11: NEWS© 2010 Nature America, Inc. Al
Page 16 and 17: © 2010 Nature America, Inc. All ri
Page 22 and 23: NEWS feature© 2010 Nature America,
Page 24 and 25: uilding a businessComing to termsDa
Page 26 and 27: uilding a business© 2010 Nature Am
Page 28 and 29: correspondence© 2010 Nature Americ
Page 36 and 37: case studyNever againcommentaryChri
Page 38 and 39: COMMENTARY© 2010 Nature America, I
Page 40 and 41: COMMENTARY© 2010 Nature America, I
Page 42 and 43: patents© 2010 Nature America, Inc.
Page 44 and 45: patents© 2010 Nature America, Inc.
Page 46 and 47: news and viewsChIPs and regulatory
Page 48 and 49: news and viewsFrom genomics to crop
Page 50 and 51: news and views© 2010 Nature Americ
Page 52 and 53: news and views© 2010 Nature Americ
Page 54 and 55: e s o u r c eRational association o
Page 56 and 57:
e s o u r c e© 2010 Nature America
Page 58 and 59:
Page 60 and 61:
Page 62 and 63:
© 2010 Nature America, Inc. All ri
Page 64 and 65:
B r i e f c o m m u n i c at i o n
Page 66 and 67:
i e f c o m m u n i c at i o n sAUT
Page 68 and 69:
lettersa1.5 kb hVPrIntron 112.5 kbA
Page 70 and 71:
letters© 2010 Nature America, Inc.
Page 72 and 73:
letters© 2010 Nature America, Inc.
Page 74 and 75:
l e t t e r sReal-time imaging of h
Page 76 and 77:
l e t t e r sFigure 2 Time-lapse li
Page 78 and 79:
l e t t e r s© 2010 Nature America
Page 80 and 81:
l e t t e r sRational design of cat
Page 82 and 83:
Page 84 and 85:
Page 86 and 87:
sample fluorescence was measured as
Page 88 and 89:
careers and recruitmentFourth quart
show all

Ontology engineering

Create successful ePaper yourself

Delete template?

Save as template?