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2003; baxter - Supplements - Haematologica

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IV International Workshop on Immune Tolerance in Hemophilia 1752. Sawamoto Y, Prescott R, Zhong D, Saenko EL, Mauser-Bunschoten E, Peerlinek K, et al. C2 domain restrictedepitope specificity of inhibitor antibodies elicited by aheat pasteurized product, factor VIII CPS-P, in previouslytreated hemophilia A patients without inhibitors.Thromb Haemost 1998;79:62-8.53. Laub R, Di Giambattista M, Fondu P, Brackmann HH,Lenk H, Saenko EL, et al. Inhibitors in German hemophiliaA patients treated with a double virus inactivatedfactor VIII concentrate bind to the C2 domain of FVIIIlight chain.\par. Thromb Haemost 1999;81:39-44.54. Bi L, Lawler AM, Antonarakis SE, High KA, Gearhart JD,Kazazian Jr HH. Targeted disruption of the mouse factorVIII gene produces a model of haemophilia A. Nat Genet1995;10:119-21.55. Sarkar R, Gao GP, Chirmule N, Tazelaar J, Kazazian HHJr. Partial correction of murine hemophilia A with neoantigenicmurine factor VIII. Hum Gene Ther 2000; 11:881-94.56. Qian J, M Borovak, Bi L, Kazazian Jr HH, Hoyer L.Inhibitor antibody development and T cell response tohuman factor VIII in murine hemophilia A. ThrombHaemost 1999;81:240-4.57. Wu H, Reding M, Qian J, Okita DK, Parker E, Lollar P,et al. Mechanism of the immune response to humanfactor VIII in murine hemophilia A. Thromb Haemost2001;85:125-33.58. Reding MT, Wu H, Krampf M, Okita DK, Diethelm-OkitaBM, Christie BA, et al. Sensitization of CD4 + T cells tocoagulation factor VIII: response in congenital andacquired hemophilia patients and in healthy subjects.Thromb Haemost 2000;84:643-52.59. Qian J, Collins M, Sharpe AM, Hoyer LW. Preventionand treatment of factor VIII inhibitors in murine hemophiliaA. Blood 2000;95:1324-9.60. Rossi G, Sarkar J, Scandella D. Long-term induction ofimmune tolerance after blockade of CD40-CD40L interactionin a mouse model of hemophilia A. Blood 2001;97:2750-7.61. Qian J, Burkly LC, Smith EP, Ferrant JL, Hoyer LW, ScottDW, Haudenschild CC. Role of CD154 in the secondaryimmune response: the reduction of pre-existing splenicgerminal centers and anti-factor VIII inhibitor titer. EurJ Immunol 2000;30:2548-54.62. Balague C, Zhou J, Dai Y, Alemany R, Josephs SF,Andreason G, et al. Sustained high-level expression offull-length human factor VIII and restoration of clottingactivity in hemophilic mice using a minimal adenovirusvector. Blood 2000;95:820-8.63. Connelly S, Andrews JL, Gallo AM, Kayda DM, Qian J,Hoyer L, et al. Sustained phenotypic correction ofmurine hemophilia A by in vivo gene therapy. Blood1998;91:3273-81.64. Evans GL, Morgan RA. Genetic induction of immunetolerance to human clotting factor VIII in a mouse modelfor hemophilia A. Proc Natl Acad Sci USA 1998; 95:5734-9.haematologica vol. 88(supplement n. 12):september <strong>2003</strong>

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