2003; baxter - Supplements - Haematologica

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Binding of factor VIIIa and factor VIII to factorIXa on phospholipid vesicles. J Biol Chem 1992; 267:17006-11.30. Bloom JW. The interaction of rDNA factor VIII, factorVIIIses-797-1562, and factor VIIIses-797-1562-derivedpeptides with phospholipid. Thromb Res 1987;48:439-48.31. Lollar P, Parke R, Curtis JE, Helgerson SL, Hoyer LW,Scott ME, Scandella D. Inhibition of human factor VII-Ia by anti-A2 subunit antibodies. J Clin Invest 1994; 93:2497-504.32. Fay PJ, Scandella D. Human inhibitor antibodies specificfor the factor VIII A2 domain disrupt the interactionbetween the subunit and factor IXa. J Biol Chem 1999;274:29826-30.33. Arai M, Scandella D, Hoyer LW. Molecular basis of factorVIII inhibition by human antibodies. Antibodies thatbind to the factor VIII light chain prevent the interactionof factor VIII with phospholipid. J Clin Invest 1989;83:1978-84.34. Saenko EL, Scandella D. The acidic region of the factorVIII light chain and the C2 domain together form thehigh affinity binding site for von Willebrand factor. JBiol Chem 1997;272:18007-14.35. Saenko EL, Shima M, Rajalakshmi KJ, Scandella D. Arole for the C2 domain of factor binding to von Willebrandfactor. J Biol Chem 1994;269:11601-5.36. Shima M, Nakai H, Scandella D, Tanaka I, Sawamoto Y,Kamisue S, et al. Common inhibitory effects of humananti-C2 domain inhibitor alloantibodies on factor VIIIbinding to von Willebrand factor. Br J Haematol 1995;91:714-21.37. Healey JF, Barrow RT, Tamim HM, Lubin IM, Shima M,Scandella D, et al. Residues Glu2181-Val2243 contain amajor determinant of the inhibitory epitope in the C2domain of human factor VIII. Blood 1998;92:3701-9.38. Healey JF, Lubin IM, Nakai H, Saenko EL, Hoyer LW,Scandella D, et al. Residues 484-508 contain a majordeterminant of the inhibitory epitope in the A2 domainof human factor VIII. J Biol Chem 1995;270:14505-9.39. 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Structure of the factor VIII C2 domainimmunoglobulinG4κ Fab complex: identification of aninhibitory antibody epitope on the surface of factor VIII.Blood 2001;98:13-9.44. Zhong D, Saenko EL, Shima M, Felch M, Scandella D.Some human inhibitor antibodies interfere with factorVIII binding to factor IX. Blood 1998;92:136-42.45. Lenting PJ, van de Loo JW, Donath MJ, van Mourik JA,Mertens K. The sequence Glu1811-Lys1818 of humanblood coagulation factor VIII comprises a binding sitefor activated factor IX. J Biol Chem 1996;271:1935-40.46. Barrow RT, Healey JF, Gailani D, Scandella D, Lollar P.Reduction of the antigenicity of factor VIII toward complexinhibitory plasmas using multiply-substitutedhybrid human/porcine factor VIII molecules. Blood2000; 95:557-61.47. Jacquemin M, Benhida A, Peerlinck K, Desqueper B,Vander EL, Lavend'homme R, et al. 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The natural history of factor VIII:Cinhibitors in patients with hemophilia A: a national cooperativestudy. II. Observations on the initial developmentof factor VIII:C inhibitors. Blood 1988;71:344-8.haematologica vol. 88(supplement n. 12):september 2003