Contents - IARC

Vitamin D and Cancer
Figure 5.2 Nonlinearity of multivariable-adjusted relation between baseline vitamin D status and incident cardiovascular events. Lowest risks of
cardiovascular event were found in subjects with baseline 25-hydroxyvitamin D of 20 to 25 ng/mL. The risk increased for values below 20 ng/mL
or above 25 ng/mL. (Wang et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation, 2008;117:503-511.)
Figure 5.2 – Caption of the original
article: Nonlinearity of multivariableadjusted
relation between baseline
vitamin D status and incident
cardiovascular events. Solid lines show
estimated relation of adjusted hazard
ratios (with 95% confidence limits) and
25-OH D levels when time to
cardiovascular event is modelled as a
function of penalised regression splines
of 25-OH D levels with adjustment for all
other covariates. Hatched lines on the
horizontal axis represent cardiovascular
events (top axis) and censored
individuals (bottom axis).
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