4060 – 4080 – <strong>Wednesday</strong> – Papers/Minisymposium 4060 — 9:30 Purine Signaling in Müller Cells During Development and in the Adult Retina in Health and Disease. Antje Grosche. Pathophysiology of Neuroglia, University of Leipzig, Leipzig, Germany 4061 — 9:45 Purinergic Signaling in Retinal Processing. Thomas E. Salt. Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom *CR 4062 — 10:00 Purines and Low Grade Inflammation at Either End of the Retina; ATP and Cytokines in Both RGCs and RPE. Claire H. Mitchell. Anatomy and Cell Biology, University of Pennsylvania Library, Philadelphia, PA *CR TCC LL 4/5 <strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM Visual Psychophysics / Physiological Optics 410 Spatial Vision, Visual Psychophysics and Aging II TCC 303 <strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM Cornea 411 Keratoconus and Biomechanics Moderator: Shukti Chakravarti 4069 — 8:30 Mutations in the zinc finger protein gene, ZNF469 contribute to the pathogenesis of keratoconus. Andrea L. Vincent 1, 2 , C. Jordan 1, 2 , B. Hay 1 , A. J. Richards 1 , C. N. McGhee 1, 2 . 1 Ophthalmology, New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand; 2 Eye Department, Greenlane Clinical Centre, Auckland District Health Board, Auckland, New Zealand *CR 4070 — 8:45 Matrix Metalloproteinase-9 drives disease progression of Keratoconus. Ashwini Ranganath, R. Shetty, S. D’Souza, K. Wadia, D. Das, A. Ghosh. cornea and refractive surgery, Narayana Nethralaya eye hospital, Bangalore, India f 4071 — 9:00 Novel proteins and metabolites for the identification of Keratoconus disease. Dimitrios Karamichos 1, 2 , J. Hjortdal 4 , A. E. Hutcheon 1, 2 , J. M. Asara 3 , J. D. Zieske 1, 2 . 1 Schepens Eye Research Institute/MEE, Boston, MA; 2 Department of Ophthalmology, Harvard Medical School, Boston, MA; 3 Division of Signal Transduction/Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; 4 Department of Ophthalmology, Aarhus University Hospital, Aarhus C, Denmark *CR 4072 — 9:15 Evaluation of transcorneal iontophoresis of riboflavin for corneal collagen cross-linking. Alejandro Arboleda 1, 2 , L. Kowalczuk 3 , M. Savoldelli 4 , C. Klein 3 , S. Ladraa 3 , J. A. Parel 1, 4 , F. F. Behar-Cohen 3, 4 . 1 Ophthalmic Biophysics Center, Dept. of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 2 Dept. of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL; 3 INSERM UMRS872: Physiopathology of Ocular Diseases: Therapeutic Innovations, Centre de Recherche des Cordeliers, Pierre et Marie Curie University, Paris Descartes University, Paris, France; 4 AP-HP Hôtel-Dieu, Dept. of Ophthalmology, Sorbonne Paris Cité, Paris Descartes University, Faculty of Medicine, Paris, France *CR 4073 — 9:30 Corneal biomechanical properties in corneal collagen cross-linking (CXL) at high fluences. Arthur Hammer 1 , O. Richoz 1 , D. Tabibian 1 , F. Hoogewoud 1 , F. Hafezi 1, 2 . 1 Ophthalmology, Geneva University Hospitals, Geneva, Switzerland; 2 Ophthalmology, Doheny Eye Institute, Keck school of medicine USC, Los Angeles, CA *CR 4074 — 9:45 Soluble collagen protects the corneal fibrils during riboflavin crosslinking. Marcos Garza-Madrid 1, 2 , J. Elisseeff 1 . 1 Translational Tissue Engineering Center, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD; 2 Ophthalmology and Visual Sciences Research Chair, School of Medicine and Health Sciences, Tecnológico de Monterrey, Monterrey, Mexico *CR 4075 — 10:00 Brillouin microscopy of collagen crosslinking: non-contact depthdependent analysis of corneal elastic modulus. Giuliano Scarcelli 1 , S. Kling 2 , E. Quijano 1 , R. Pineda 3 , S. Marcos 2 , S. H. Yun 1 . 1 Wellman Center for Photomedicine, Harvard Medical School, Cambridge, MA; 2 Instituto de Optica, Conjejo Superior de investigation cientifica, Madrid, Spain; 3 Ophthalmology, Mass eye and ear Infirmary, Boston, MA *CR TCC 304 <strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM Visual Neuroscience 412 Photoreceptors: Structure, Transduction, Signaling <strong>Wednesday</strong> Papers/ Minisymposium 8:30 am – 10:15 am Moderators: Joanne M. Wood and Heidi J. Hofer 4063 — 8:30 Two-point detection and appearance in the absence of higher order aberrations. Heidi J. Hofer, D. E. Koenig. College of Optometry, University of Houston, Houston, TX 4064 — 8:45 A Comparison of Acuity and Cone Density in the Temporal Retina. Nancy J. Coletta 1 , T. Y. Chui 2 , A. E. Elsner 2 . 1 Vision Science, New England College of Optometry, Boston, MA; 2 School of Optometry, Indiana University, Bloomington, IN *CR 4065 — 9:00 Age-related variation in foveal, parafoveal and peripheral spatial suppression. Rigmor C. Baraas, C. Aaen-Stockdale, S. J. Gilson. Optometry & Visual Science, Buskerud University College, Kongsberg, Norway 4066 — 9:15 Heterochromatic Modulation Photometry can be used to measure Macular Pigment Optical Density. Cord R. Huchzermeyer 1 , J. Schlomberg 1 , U. Welge-Lüssen 1 , T. Berendschot 2 , J. J. Kremers 1 . 1 Department of Ophthalmology, University Erlangen-Nuremberg, Erlangen, Germany; 2 University Eye Clinic, Maastricht, Netherlands 4067 — 9:30 Comparability of Visual Performance of Individuals with Low Vision in Real and Virtual Street Intersections. Lei Liu, E. L. Bowman. School of Optometry, University of Alabama at Birmingham, Birmingham, AL 4068 — 9:45 Optical quality and subjective judgments of blur under pure simultaneous vision. Carlos Dorronsoro, A. Radhakrishnan, L. Sawides, S. Marcos. Instituto de Optica, CSIC, Madrid, Spain *CR Moderators: Marie E. Burns and Wolfgang Baehr 4076 — 8:30 Modulating the phototransduction cascade with small molecules. Tomoki Isayama 1 , J. Wu 1 , S. Miyazono 1 , V. Lee 1 , E. S. Levine 1 , E. Makino 3 , A. L. Zimmerman 2 , C. L. Makino 1 . 1 Ophthalmology, Mass Eye & Ear Infirmary, Boston, MA; 2 Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI; 3 LGCR, Sanofi Corporation, Waltham, MA 4077 — 8:45 Under-expression of GAP proteins: Effect on Mouse Rod Response Decay. Gordon L. Fain 1, 2 , M. L. Woodruff 1 , C. J. Chen 3 . 1 Integrative Biology and Physiology, Univ of California-Los Angeles, Los Angeles, CA; 2 Jules Stein Eye Institute, UCLA, Los Angeles, CA; 3 Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 4078 — 9:00 Light-induced translocation of RGS9-1 and Gβ5L in Mouse Rod Photoreceptors. You-Wei Peng 1 , M. Tian 1 , M. L. Zallocchi 1 , W. Wang 1 , C. J. Chen 2 , K. Palczewski 3 , D. E. Cosgrove 1 . 1 Genetics, Boys Town Natl Research Hosp, Omaha, NE; 2 Biochemistry & Molecular Biology, Virginia Commonwealth University, Richmond, VA; 3 Pharmacology, Case Western Reserve University, Cleveland, OH *CR 4079 — 9:15 Complete protein composition of the photoreceptor disc identified by label-free quantitative proteomics. Nikolai P. Skiba, V. Y. Arshavsky. Duke University, Durham, NC 4080 — 9:30 Molecular Function of Peripherin-2/rds for Photoreceptor Membrane Structure. Andrew F. Goldberg, N. Khattree, L. M. Ritter. Eye Research Institute, Oakland University, Rochester Hills, MI The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 272
<strong>Wednesday</strong> – Papers/Minisymposium – 4081 – 4082 4081 — 9:45 Bleach-Induced Desensitization and Response Compression of the Photocurrent and Photovoltage in Mouse Rods. Johan Pahlberg 1 , R. Frederiksen 2 , K. J. Miyagishima 1 , S. Nymark 2 , A. P. Sampath 1 , M. C. Cornwall 2 . 1 Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA; 2 Boston University Medical School, Department of Physiology and Biophysics, Boston, MA 4082 — 10:00 Phosphoinositides and membrane trafficking in zebrafish cone inner segments. Sara Hayden, S. E. Brockerhoff. Biochemistry, University of Washinton, Seattle, WA <strong>Wednesday</strong> Papers/ Minisymposium 8:30 am – 10:15 am f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 273
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