Wednesday - ARVO

4040 — 9:45 The role of central retina in
chicks during form deprivation myopia. Jianchao
Wang 1, 2 , R. Chun 1 , K. Li 1 , Q. Liu 1, 2 , C. To 1, 2 .
1
Laboratory of Experimental Optometry, Centre
for Myopia Research, School of Optometry, The
Hong Kong Polytechnic University, HongKong,
China; 2 State Key Laboratory of Ophthalmology,
Zhongshan Ophthalmic Centre, Sun Yat-sen
University, Guangzhou, China
4041 — 10:00 Photoreceptor Outer Retinal
Function as the Primary Controller of Ocular
Growth. David P. Crewther 1, 2 , S. N. Kiely 2 , M.
J. Murphy 2 , N. Riddell 2 , S. G. Crewther 2 . 1 Centre
for Human Psychopharmacology, Swinburne
Univ of Technology, Melbourne, VIC, Australia;
2
Psychological Science, La Trobe University,
Melbourne, VIC, Australia
4048 — 10:00 Linking the optical properties of
the lens to its cellular physiology: a multimodal
imaging and modelling approach. Ehsan Vaghefi
Rezaei 1 , A. Kim 1 , P. J. Donaldson 2, 1 . 1 Department
of Optometry and Vision Sciences, University
of Auckland, Auckland, New Zealand; 2 School
of Medical Sciences, University of Auckland,
Auckland, New Zealand
611-614
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Retinal Cell Biology
408 Differentiation of Stem and
iPS Cells
Wednesday – Papers/Minisymposium – 4040 – 4059
4054 — 9:45 Investigating the pathophysiology
of USH2A associated retinal degeneration with
patient specific iPSCs. Budd A. Tucker 1 , R. F.
Mullins 1 , K. R. Anfinson 1 , L. M. Affatigato 1 , J.
A. Halder 1 , P. M. Brzeskiewicz 1 , E. M. Stone 1, 2 .
1
Ophthalmology, Inst for Vision Rsrch, Univ of
Iowa, Iowa City, IA; 2 HHMI Investigator, Iowa
City, IA *CR
4055 — 10:00 Differentiation of iPS-RPE
cells from a patient with clinical anophthalmia.
Amanda-Jayne F. Carr 1 , L. Ho 2 , L. Chen 1 , G. Selva
Raj 2 , A. A. Vugler 1 , M. A. Shboul 2 , A. Colman 2 ,
B. Reversade 2 , P. J. Coffey 1 . 1 Division of ORBIT,
Institute of Ophthalmology, University College
London, London, United Kingdom; 2 Dept. of
Paediatrics, A*STAR Institute of Medical Biology,
Biopolis, Singapore
609
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Lens
407 Cell Biology Impacts
Lens Function
Moderators: Marc Kantorow and A S. Menko
4042 — 8:30 JNK inactivation suppresses
mTOR (Mammalian Target of Rapamycin)
pathway to induce loss of nuclei and organelles
in the lens through Autophagy. Subhasree Basu 1 ,
S. Rajakaruna 1 , B. A. Reyes 2 , E. J. Van Bockstaele 2 ,
A. S. Menko 1, 3 . 1 Pathology Anatomy & Cell
Biology, Thomas Jefferson University, Philadelphia,
PA; 2 Neuroscience, Thomas Jefferson University,
Philadelphia, PA; 3 Wills Vision Research Center at
Jefferson, Philadelphia, PA
4043 — 8:45 Autophagy mediates
mitochondrial degradation in the developing
and adult eye lens. Marc Kantorow 1 , D. Chauss 1 ,
A. Mohamed 2 , K. Gilliland 3 , L. A. Brennan 1 , M. J.
Costello 3 . 1 Biomedical Sciences, Florida Atlantic
University, Boca Raton, FL; 2 L. V. Prasad Eye
Institute, Hydrabad, India; 3 Cell Biology and
Physiology, University of North Carolina, Chapel
Hill, NC
4044 — 9:00 Loss of Pten Rescues Akt
Phosphorylation, Apoptosis and Size in Fgfr2
Deficient Lenses. Blake R. Chaffee, M. R. Leonard,
B. D. Wagner, M. L. Robinson. Zoology, Miami
University, Oxford, OH
4045 — 9:15 Role of Birc7 in the Mouse Lens.
Alicia De Maria, S. Bassnett. Ophthalmology and
Visual Sciences, Washington University, St Louis,
MO
4046 — 9:30 The Optical Quality of Inhibitor-
Treated Avian Crystalline Lenses. Gah-Jone
Won, V. Choh. School of Optometry, University of
Waterloo, Waterloo, ON, Canada
4047 — 9:45 Estimation of Ciliary Muscle
Forces Required to Induce Corneal Deformation.
Robert P. Wilkes, M. A. Reilly. Biomedical
Engineering, University of Texas at San Antonio,
San Antonio, TX
Moderators: Jason S. Meyer and G Astrid Limb
4049 — 8:30 MITF regulation of early cell fate
in a human embryonic stem cell model of retinal
development. Elizabeth E. Capowski 1 , J. Simonett 1 ,
E. Clark 1 , L. S. Wright 1 , I. Pinilla Lozano 2, 3 , J.
Phillips 1 , K. Wallace 1 , D. M. Gamm 4, 5 . 1 Waisman
Center, University of Wisconsin-Madison, Madison,
WI; 2 Ophthamology, University Hospital Lozano
Blesa, Zaragoza, Spain; 3 IIS Aragon, Aragon Health
Sciences Institute, Zaragoza, Spain; 4 Ophthamology
and Visual Sciences, University of Wisconsin-
Madison, Madison, WI; 5 McPherson Eye Research
Institute, University of Wisconsin-Madison,
Madison, WI *CR
4050 — 8:45 Simplified and Efficient
Generation of Photoreceptors from Human
Pleuripotent Stem Cells. Joo Young Shin, H. Yu.
Ophthalmology, Seoul National University, Seoul,
Republic of Korea
4051 — 9:00 Improving Human RPE
Differentiation from iPS Cells: Lessons from
Mouse Eye Development. Kapil Bharti 1 , J.
Davis 1 , B. Corneo 2 , Q. Wan 1 , K. J. Miyagishima 1 ,
S. Temple 2 , S. S. Miller 1 . 1 NEI, National Institutes
of Health, Bethesda, MD; 2 National Eye Institute,
National Institutes of Health, Bethesda, MD *CR
4052 — 9:15 Investigating the role of VSX2
(CHX10) in human retinogenesis using iPS cells.
Joe Phillips 1, 2 , E. Perez 1 , K. Wallace 1 , J. M. Martin 1 ,
R. Singh 1 , E. E. Capowski 1 , L. S. Wright 1 , E. Clark 1 ,
E. F. Percin 3 , D. M. Gamm 1, 2 . 1 Waisman Center,
University of Wisconsin, Madison, WI; 2 McPherson
Eye Research Institute, University of Wisconsin,
Madison, WI; 3 Medical Genetics, Gazi University,
Ankara, Turkey *CR
4053 — 9:30 Differentiation of Human
Protein Induced Pluripotent Stem Cells (piPS)
Towards a Retinal Pigment Epithelium (RPE)
Fate. Jie Gong, M. A. Fields, L. V. Del Priore.
Ophthalmology, MUSC Storm Eye Institute,
Charleston, SC
618-620
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Physiology/Pharmacology / Cornea /
Retinal Cell Biology
409 Purine Signaling in the Eye: Role
in Health and Disease - Minisymposium
The field of purine signaling is rapidly expanding,
with a great diversity of roles in health and
disease. Purine receptors (P1 Adenosine and P2
Purine/Nucleotide receptors) have been identified
throughout the tissues of the eye with proposed
roles in processes including control of intraocular
pressure, visual processing and mediation of
inflammatory responses. This symposium explores
purine signaling in ocular tissues: lacrimal gland,
trabecular meshwork, lens and retina. Questions
are asked about the role of purine signaling in
healthy ocular tissue, including in development
and in retinal processing, as well as addressing the
consequences of dysregulation to ocular health in
disease, including dry eye and glaucoma. Purine
receptors as putative drug targets for ocular disease
are also discussed.
Moderators: Julie Sanderson, Claire H. Mitchell
and Claudio Bucolo
4056 — 8:30 Introduction to Purine Signaling.
Julie Sanderson. School of Pharmacy, University of
East Anglia, Norwich, United Kingdom
4057 — 8:45 Purine Signaling in the
Trabecular Meshwork: A Regulator of
Intraocular Pressure. Mortimer M. Civan.
Physiology-Richards Bldg, Univ of Pennsylvania
Sch of Med, Philadelphia, PA
4058 — 9:00 Purinergic Receptors in Lacrimal
Gland Health and Dry Eye Disease. Darlene A.
Dartt. Schepens Eye Research Institute, Boston,
MA
4059 — 9:15 TRPV4 and Hemichannels
Cooperate to Play a Critical Role in Purine
Signaling in the Lens. Nicholas A. Delamere.
Physiology, University of Arizona, Tucson, AZ
Wednesday Papers/
Minisymposium
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
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