Wednesday - ARVO

4022 – 4039 – Wednesday – Papers/Minisymposium
Wednesday Papers/
Minisymposium
8:30 am – 10:15 am
4022 — 10:00 Nonsyndromic RP Due to BBS2
Mutations. Meghan J. Marino 1 , G. J. Pauer 1 ,
J. Chiang 3 , S. A. Hagstrom 1, 2 , E. I. Traboulsi 1, 2 .
1
Ophthalmic Research, Cole Eye Institute,
Cleveland Clinic, Cleveland, OH; 2 Ophthalmology,
Cleveland Clinic Lerner College of Medicine Case
Western Reserve University, Cleveland, OH; 3 Casey
Eye Institute Molecular Diagnostics Laboratory,
Portland, OR *CR
6E
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Retina
404 DR: Therapeutic Effects
Moderator: Peter A. Campochiaro
4023 — 8:30 Intravitreal ranibizumab (RBZ)
suppresses posterior retinal nonperfusion (RNP)
in patients with diabetic macular edema (DME).
Peter A. Campochiaro 1 , C. Wykoff 2 , D. Chen 3 , H.
Shapiro 4 , J. S. Ehrlich 5 , R. Rubio 6 . 1 Ophthalmology
and Neuroscience, Johns Hopkins Wilmer Eye
Inst, Baltimore, MD; 2 Retina Consultants of
Houston, Houston, TX; 3 Genentech, Inc., South
San Francisco, CA; 4 Genentech, Inc., South
San Francisco, CA; 5 Genentech, Inc., South San
Francisco, CA; 6 Genentech, Inc., South San
Francisco, CA *CR, f
4024 — 8:45 Intensive Diabetes Therapy
Reduces Ocular Surgeries in Patients with
Type 1 Diabetes: twenty-eight year followup of
the Diabetes Control and Complications Trial
/ Epidemiology of Diabetes Interventions and
Complications study (DCCT/EDIC). Lloyd P.
Aiello 1, 2 , W. Sun 5 , P. A. Cleary 5 , J. M. Lachin 5 ,
S. Gangaputra 3 , R. Klein 4 , A. Das 7 , S. Kiss 6 , A.
Domalpally 3 , R. P. Danis 3 . 1 Beetham Eye Institute,
Joslin Diabetes Center, Boston, MA; 2 Department
of Ophthalmology, Harvard Medical School,
Boston, MA; 3 Fundus Photograph Reading Center,
University of Wisconsin, Madison, WI; 4 Department
of Ophthalmology and Visual Sciences, University
of Wisconsin School of Medicine and Public
Health, Madison, WI; 5 Biostatistics Center, George
Washington University, Rockville, MD; 6 Clinical
Research, Weill Cornell Medical College, New
York, NY; 7 University of New Mexico School of
Medicine, Albuquerque, NM *CR, f
4025 — 9:00 Canadian PhIIIb study:
ranibizumab combination/monotherapy in visual
impairment due to DME: Preliminary Analysis.
Thomas Sheidow 1, 2 , A. R. Berger 3 , F. deTakacsy 4 ,
R. Li 4 , B. Rehel 5 , A. Courseau 4 . 1 Ivey Eye Institute,
London, ON, Canada; 2 Ophthalmology, Western
University, London, ON, Canada; 3 St. Michael’s
Hospital, Toronto, ON, Canada; 4 Novartis
Pharmaceuticals Canada Inc., Dorval, QC, Canada;
5
Everest Clinical Research Services, Inc., Markham,
ON, Canada *CR, f
4026 — 9:15 Baseline Predictors of
improvement in self-reported visual function
following treatment with ranibizumab in patients
with diabetic macular edema. Rohit Varma 1 , N.
M. Bressler 2 , C. Dolan 3 , L. Yau 3 , J. F. Ward 3 , S.
Colman 3 . 1 Ophthalmology and Visual Sciences,
University of Illinois at Chicago Eye and Ear
Infirmary, Chicago, IL; 2 Retina Division, Wilmer
Eye Institute, Johns Hopkins University School of
Medicine, Baltimore, MD; 3 Genentech, Inc., South
San Francisco, CA *CR, f
4027 — 9:30 Effect of Statins and Diabetes
Therapy (Oral Hypoglycemics and Insulin)
on the Outcomes of Patients Treated with
Ranibizumab and/or Laser Therapy. Mohammad
A. Sadiq 1 , M. Hassan 1 , Y. J. Sepah 1 , G. K. Loh 2, 1 , S.
Kherani 1 , M. Hanout 1 , R. E. Annam 1 , M. Ansari 1 ,
D. V. Do 1 , Q. Nguyen 1 . 1 Retinal Imaging Research
and Reading Center, Wilmer Eye Institute. Johns
Hopkins University, Baltimore, MD; 2 Division
of medicine, University College London Medical
School, London, United Kingdom *CR, f
4028 — 9:45 Effects of Intravitreal
Ranibizumab on Diabetic Retinopathy Severity:
36 Month Data from the RISE and RIDE Phase
III Trials. Jason S. Ehrlich 1 , A. Domalpally 2 ,
L. Yau 1 , J. J. Hopkins 1 , M. S. Ip 2 . 1 Genentech,
Inc, South San Francisco, CA; 2 Department of
Ophthalmology and Visual Sciences, University of
Wisconsin Medical School, Madison, WI *CR, f
4029 — 10:00 RELIGHT - Ranibizumab
treatment of diabetic macular oedema with
bimonthly monitoring after a phase of initial
Treatment. Ian A. Pearce. Royal Liverpool
University Hospital, St Paul’s Eye Unit, Liverpool,
United Kingdom *CR, f
606/607
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Immunology/Microbiology / Cornea
405 Host Responses to Ocular
Herpesvirus Infection - What Have
We Learned and What Is the Future
Direction? - Minisymposium
This session will cover current data and concepts
from clinical presentation, immune response/
regulation to virus infection, and development of
novel treatment strategies.
Moderators: Daniel J. Carr and Barry T. Rouse
4030 — 8:30 Insights into Natural History
of HSV Infections in the Era of Changing
Epidemiology. Anna Wald. University of
Washington, Seattle, WA *CR
4031 — 9:00 Herpes Simplex Virus Evasion of
Host Immunity and the Autophagy Response.
David A. Leib. Microbiology and Immunology HB
7556, Dartmouth Medical School, Lebanon, NH
4032 — 9:20 Chronic Murine Cytomegalovirus
Infection results in more severe Experimental
Choroidal Neovascularization. Richard D. Dix.
Department of Biology, Georgia State University,
Atlanta, GA
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
270
4033 — 9:40 Pathogenesis of Herpes
Stromal Keratitis - A Focus on Corneal
Neovascularization. Barry T. Rouse. Pathobiology,
Univ of Tennessee Coll of Vet Med, Knoxville, TN
4034 — 10:00 Discussion. Todd P. Margolis.
UCSF Proctor Foundation, Univ of California-San
Francisco, San Francisco, CA *CR
608
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Anatomy/Pathology
406 Myopia and Emmetropization
Moderators: Frank Schaeffel and Chi-ho To
4035 — 8:30 Distribution and Determinants
of Eye Size and Shape in Newborn Children:
a Magnetic Resonance Imaging Analysis.
Laurence S. Lim 1, 2 , P. Tan 2 , G. Chong 2 , Y. Chong 2 ,
M. V. Fortier 3 , P. Gluckman 4, 5 , S. Saw 2, 1 , A. Qiu 2 .
1
Ophthalmology, Singapore National Eye Center,
Singapore, Singapore; 2 National University of
Singapore, Singapore, Singapore; 3 KK Women’s
and Children’s Hospital, Singapore, Singapore;
4
Singapore Institute for Clinical Sciences, the
Agency for Science, Technology and Research,
Singapore, Singapore; 5 Liggins Institute, University
of Auckland, Auckland, New Zealand *CR
4036 — 8:45 Central retinal thickness and
axial length in the Copenhagen Child Cohort
2000 study: data from 432 11-year-old children.
Xiao Q. Li 1 , M. Larsen 1 , I. C. Munch 2 . 1 Department
of Ophthalmology, Glostrup Hospital, Glostrup,
Denmark; 2 Department of Ophthalmology, Roskilde
Hospital, Roskilde, Denmark
4037 — 9:00 Neurochemical Ablation of
Peripheral Glucagonergic Amacrine Cells in
the Chick Retina and its Effects on Axial Eye
Growth and Refractive Error. Diane Nava 1, 2 , A.
Chang 2 , L. A. Ostrin 2 , Z. Chen 2, 3 , C. F. Wildsoet 1, 2 .
1
Vision Science Group, UC Berkeley, Berkeley,
CA; 2 Center for Eye Disease and Development,
UC Berkeley School of Optometry, Berkeley, CA;
3
Department of Opthalmology and Vision Science,
Fudan University Eye and ENT Hospital, Shanghai,
China
4038 — 9:15 Ocular growth guided by dual
focal fresnel lenses requires an intact optic
nerve. Sally A. McFadden 1 , D. Y. Tse 2 , C. To 2 , C.
F. Wildsoet 3 . 1 School of Psychology, University of
Newcastle, Callaghan, NSW, Australia; 2 School of
Optometry, The Hong Kong Polytechnic University,
Kowloon, Hong Kong; 3 School of Optometry,
University of California, Berkeley, CA
4039 — 9:30 Effects of Long-Wavelength-
Pass Filters on Refractive Development in
Rhesus Monkeys. Earl L. Smith 1, 2 , L. Hung 1, 2 ,
B. Arumugam 1, 2 , J. Huang 1, 2 , M. Neitz 3 , J. Neitz 3 .
1
College of Optometry, University of Houston,
Houston, TX; 2 Vision Cooperative Research
Centre, Sydney, NSW, Australia; 3 Department of
Ophthalmology, University of Washington Medical
School, Seattle, WA *CR