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<strong>Wednesday</strong> – Papers/Minisymposium – 4002 – 4021 6A <strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM Biochemistry/Molecular Biology / Biochemistry/ Molecular Biology 401 Biochemistry of Glaucoma Moderators: Stanislav I. Tomarev and Ernst R. Tamm 4002 — 8:30 Myocilin affects differentiation of oligodendrocytes and regulates myelination of the optic nerve via Lingo-1/RhoA signaling. Stanislav I. Tomarev 1 , H. Kwon 1 , N. Nakaya 1 , M. S. Abu-Asab 2 . 1 SRGCB, LRCMB, National Eye Institute, Bethesda, MD; 2 Histopathology Core Facility, National Eye Institute, Bethesda, MD 4003 — 8:45 Genomewide DNA methylation analysis of human trabecular meshwork cells with dexamethasone stimulation. Akira Matsuda, N. Ebihara, A. Murakami. Department of Ophthalmology, Juntendo Univ School of Med, Tokyo, Japan *CR 4004 — 9:00 Stabilization of Myocilin with Small Molecules Prevents Its Aggregation. Raquel L. Lieberman, S. E. Hill, R. K. Donegan, K. C. Turnage. School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA 4005 — 9:15 PGC-1alpha Signaling Regulates Retinal Ganglion Cell Injury Responses And Atrocyte Reactivity. Jeremy M. Sivak 1, 2 , X. Guo 1 , S. Dason 2 , A. Nahirny 1 . 1 Vision Sciences, Toronto Western Hospital, University Health Network, Toronto, ON, Canada; 2 Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada 4006 — 9:30 Subcellular mislocalization and loss of function of mutant Gpnmb proteins. Alexander C. Theos. Human Science, Georgetown University, Washington, DC 4007 — 9:45 Cochlin and phosphatidylcholines interact with SLC44A2 channel on the trabecular meshwork cells. Sanjoy K. Bhattacharya, M. Martinez, A. Aljohani, R. K. Lee. Bascom Palmer Eye Institute, Univ of Miami Miller Sch of Med, Miami, FL *CR 4008 — 10:00 Disruption of the homeostatic balance between TGF-β and BMPs in the outflow tissues of the CTGF-based Glaucoma mouse model. Sabrina Kuespert, E. R. Tamm, R. Fuchshofer. University Regensburg, Institut of Human Anatomy and Embryology, Regensburg, Germany 6B <strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM Glaucoma 402 New Ideas Moderators: Jonathan G. Crowston, Peng T. Khaw and George A. Cioffi 4009 — 8:30 Glucose-induced Temporary Visual Recovery in Human Glaucoma: A Prospective, Double-blind, Randomised Study. Robert J. Casson, G. Chidlow, A. Ebneter, G. Han, J. Gilhotra, J. P. Wood. SA Institute of Ophthalmology, SA Inst of Ophthalmol, Adelaide Univ, Adelaide, SA, Australia f 4010 — 8:45 Radiation Treatment Does Not Protect the Rat Optic Nerve from Elevated Intraocular Pressure (IOP)-Induced Injury. Elaine C. Johnson, W. Cepurna, J. C. Morrison. Ophthalmology, Casey Eye Institute-OHSU, Portland, OR 4011 — 9:00 Estrogen Pathway Polymorphisms in Relation to Primary Open Angle Glaucoma: A Gender-Specific Analysis from Patients in the United States. Louis R. Pasquale 1, 2 , S. Loomis 1 , B. Yaspan 3 , J. H. Kang 2 , R. N. Weinreb 6 , J. E. Richards 7 , M. A. Hauser 4 , J. L. Haines 5 , J. L. Wiggs 1 . 1 Ophthalmology, Mass Eye & Ear Infirmary, Boston, MA; 2 Medicine, Brigham and Women’s Hospital, Boston, MA; 3 Genentech, Inc, San Francisco, CA; 4 Ophthalmology, Duke University, Durham, NC; 5 Center for Human Genetics Research, Vanderbilt University, Nashville, TN; 6 Ophthalmology, UCSD, San Diego, CA; 7 Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI *CR 4012 — 9:15 A Novel Device for Clinical Measurement of Corneal Elasticity. Christopher K. Leung 1 , C. Ye 1 , M. Ko 2 , L. Leung 2 , D. Lam 2 . 1 Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong; 2 Mechanical Engineering, Hong Kong University of Science and Technology, Hong Kong, Hong Kong *CR 4013 — 9:30 A Potential Role for the Hypothalamic Orexin System in Mediating Intraocular Pressure Fluctuations. Brian C. Samuels 1 , N. Hammes 1 , P. L. Johnson 2 , A. Shekhar 3, 4 . 1 Department of Ophthalmology, Eugene & Marilyn Glick Eye Inst, Ind Univ, Indianapolis, IN; 2 Department of Anatomy, Indiana University, Indianapolis, IN; 3 Department of Psychiatry, Indiana University, Indianapolis, IN; 4 Clinical and Translational Sciences Institute, Indiana University, Indianapolis, IN *CR 4014 — 9:45 Pulse-induced Trabecular Meshwork (TM) Movement in Humans: Characterization by Phase-sensitive OCT (PhS-OCT). Murray A. Johnstone 2 , P. Li 1 , T. T. Shen 1, 2 , R. K. Wang 1 . 1 Bioengineering, University of Washington, Seattle, WA; 2 Ophthalmology, University of Washington, Seattle, WA *CR 4015 — 10:00 A quantitative approach to the analysis of visual field defect location and its relationship to measures of disability. Michael V. Boland, P. Y. Ramulu, K. S. Arora, J. L. Jefferys, D. S. Friedman. Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD *CR 6C <strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM Retina 403 Retinitis Pigmentosa II Moderators: Yasuhiro Ikeda and David J. Wilson 4016 — 8:30 Long-term efficacy and safety of treatment of retinitis pigmentosa with valproic acid. Christine N. Kay, S. Bhalla. Ophthalmology, University of Florida, Gainesville, FL 4017 — 8:45 Visual Function Improvements following Electroacupuncture for Retinitis Pigmentosa. Ava K. Bittner 1 , J. Gould 3 , C. Rozanski 1 , A. Rosenfarb 2 , M. R. DeJong 3 , A. Benavente-Perez 4 , G. Dagnelie 1 . 1 Ophthalmology, Johns Hopkins University, Baltimore, MD; 2 Acupuncture Health Associates, Westfield, NJ; 3 Johns Hopkins University, Baltimore, MD; 4 SUNY College of Optometry, New York, NY f 4018 — 9:00 Evaluation of peripheral retinal vasculitis in retinitis pigmentosa using wide-field fluorescein angiography. Matthew B. Kaufman 1, 2 , C. A. Medina-Mendez 1, 2 , T. R. Friberg 1, 2 , A. W. Eller 1, 2 . 1 Ophthalmology, UPMC Eye Center, Pittsburgh, PA; 2 Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA *CR 4019 — 9:15 Inheritance of Retinitis Pigmentosa: Update in the Era of Genetic Testing. Kari E. Branham, J. Huang, K. T. Jayasundera, J. R. Heckenlively. Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI *CR 4020 — 9:30 Ultra wide-field autofluorescence is useful to evauluate residual retinal functions in patients with Retinitis Pigmentosa. Shuntaro Ogura, T. Yasukawa, M. Yoshida, Y. Ogura. Department of Ophthalmology, Nagoya City Univ Medical School, Nagoya, Japan 4021 — 9:45 Recombinant Human Nerve Growth Factor Protects Photoreceptor Degeneration in a Rat Model of Inherited Retinitis Pigmentosa. Luigi Aloe 1 , P. Bianchi 1 , M. Rocco 1 , A. Micera 2 , A. Lambiase 3 , S. Bonini 3 . 1 Institute of Neurobiology and Molecular Medicine, National Research Council, Rome, Italy; 2 G.B. Bietti IRCCS, Rome, Italy; 3 Department of Ophthalmology, University of Rome, Campus Biomedico, Rome, Italy *CR <strong>Wednesday</strong> Papers/ Minisymposium 8:30 am – 10:15 am f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 269