Wednesday - ARVO

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4642 – 4666 – Wednesday – Posters Wednesday Posters 11:00 am – 12:45 pm 4642 — B0106 3-D Computer-Automated Threshold Amsler Grid to Quantify Retinal Deficits Before and After Standard Treatment of Wet Age-related Macular Degeneration. Kristie Lin 1 , W. Fink 2, 3 , S. Kamjoo 1 , M. Davis 1 , T. Chang 1 . 1 Retina Institute of California, Arcadia, CA; 2 Physics, Mathematics and Astronomy, California Institute of Technology, Pasadena, CA; 3 Biomedical Engineering, University of Arizona, Tuscon, AZ *CR, f 4643 — B0107 Treatment of retinal capillary hemangioblastoma using inhibitors of the HIF pathway. Mridul Mukherji, D. Vavilala, P. Swami, V. Ponnaluri. Pharmacy - Pharmaceutical Sci, Univ of Missouri - Kansas City, Kansas City, MO 4644 — B0108 Short-term Effects of Cocoa on Retinal Reactivity in Individuals with Prediabetes and Type 2 Diabetes. Mary E. Lott 1 , A. Johns 1 , J. Oman 1 , J. E. Slocomb 2 , M. Herr 1 , R. A. Gabbay 3 , D. A. Quillen 4 , K. Bettermann 2 . 1 Heart and Vascular Institute, Penn State Milton S Hershey Med Ctr, Hershey, PA; 2 Neurology, Penn State Milton S Hershey Med Ctr, Hershey, PA; 3 Endocrinology, Penn State Milton S Hershey Med Ctr, Hershey, PA; 4 Opthalmology, Penn State Milton S Hershey Med Ctr, Hershey, PA 4645 — B0109 Altered Vascular Microenvironment by Bevacizumab in Diabetic Fibrovascular Membrane. Shintaro Nakao 1 , K. Ishikawa 1 , S. Yoshida 1 , R. Kohno 1 , M. Miyazaki 1 , H. Enaida 1 , T. Kono 2 , T. Ishibashi 1 . 1 Ophthalmology, Kyushu University, Fukuoka, Japan; 2 Ophthalmology, Fukuoka University, Fukuoka, Japan 4646 — B0110 Retinal Oxygenation During Intravitreal Treatment for Central Retinal Vein Occlusion. Sindri Traustason, M. D. de La Cour, M. Larsen. Dept of Ophthalmology,Glostrup Univ Hosp, Copenhagen University, Glostrup, Denmark *CR, f 4647 — B0111 Rationale for Bimonthly Ranibizumab and Quarterly Aflibercept. A Drug and Disease Assessment Model in Wet Agerelated Macular Degeneration. Daniele Veritti 1 , G. Gorni 2 , L. Perissin 3 , P. Lanzetta 1 . 1 Department of Ophthalmology, University of Udine, Udine, Italy; 2 Department of Mathematics and Computer Science, University of Udine, Udine, Italy; 3 Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy *CR 4648 — B0112 Retinal Vein Occlusions in Young Patients: Visual Outcomes and Associated Systemic Risk Factors. Noureen Khan 1, 2 , M. M. Lai 1, 2 . 1 Dept. of Ophthalmology, Georgetown University/Washington Hospital Center, Washington, DC; 2 The Retina Group of Washington, Chevy Chase, MD 4649 — B0113 Effects of Prostacyclin on Isolated Porcine Retinal Arterioles: Cross-Talk between Nitric Oxide and Prostacyclin. Shinji Ono, T. Nagaoka, T. Omae, T. Kamiya, A. Yoshida. Ophthalmology, Asahikawa Med University, Asahikawa, Japan *CR 4650 — B0114 Perifoveal Microvasculature in Human Eyes with Vascular Comorbidities. Geoffrey Chan 1, 2 , C. Bala 1, 2 , P. Yu 1, 2 , W. Morgan 1 , I. L. McAllister 1 , S. J. Cringle 1, 2 , Y. Dao-Yi 1, 2 . 1 Centre for Ophthalmology and Visual Science, Perth, WA, Australia; 2 Australian Research Council Centre of Excellence in Vision Science, Canberra, ACT, Australia *CR 4651 — B0115 Flavonoid-rich dark chocolate improves endothelial function in retinal vessels. Naim Terai, A. Gedenk, E. Spoerl, R. P. Stodtmeister. Ophthalmology, University of Dresden, Dresden, Germany *CR 4652 — B0116 Inhibition of retinal neovascularization by luteolin via suppression of VEGF expression and VEGFR signaling pathway. Sung Wook Park 1, 2 , C. Cho 1 , H. Jun 1 , N. Ryu 3 , J. Kim 1 , Y. S. Yu 1 , J. Kim 3 , J. Kim 1, 2 . 1 FARB, Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea; 2 Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea; 3 Diabetic Complications Research Center, Division of Traditional Korean Medicine Integrated Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea 4653 — B0117 Plasma VEGF-levels are variable in patients with persistent renal dysfunction and diabetes: possible implications and risks for ophthalmic anti-VEGF therapy. Markus van der Giet, M. Schuchardt, N. Pruefer, J. Pruefer. Med. Klinik - SP Nephrology, Charite - Universitätsmedizin Berlin, Berlin, Germany *CR 4654 — B0118 Pathological retinal neovascularization is exacerbated by selective pharmacological blockade of VEGFR2, but ameliorated by combination with Placental Growth Factor (PlGF) inhibition in the Oxygen induced Retinopathy (OIR) model in mice. Eunice Cheung, I. B. Lobov, G. D. Yancopoulos, S. J. Wiegand. Ophthalmology, Regeneron Pharmaceuticals, Inc., Tarrytown, NY *CR 4655 — B0119 Treatment of proliferative idiopathic macular telangiectasia Type 2 with intravitreal bevacizumab. Ranjit Sandhu, R. D. Hamilton. Medical Retina, Moorfields Eye Hospital, London, United Kingdom *CR 4656 — B0120 Computational model of blood flow through the choriocapillaris highlights marked heterogeneity of blood flow. Moussa A. Zouache 1, 2 , P. J. Luthert 1, 2 , I. Eames 3 . 1 Institute of Ophthalmology, University College London, London, United Kingdom; 2 NIHR Biomedical Research Centre in Ophthalmology, London, United Kingdom; 3 Department of Mechanical Engineering, University College London, London, United Kingdom 4657 — B0121 Periocular injection of a broad spectrum antiangiogenic therapy regresses choroidal neovascularization. Ofra Benny, Z. Chi, L. Bazinet, R. J. D’Amato. Boston Children’s Hospital, Harvard Medical School, Boston, MA *CR 4658 — B0122 Efficacy and safety of subconjunctival bevacizumab for recurrent pterygium. Larissa S. Stival 1 , A. M. Lago 1 , M. N. Figueiredo 1 , R. G. Bittar 2 , M. L. Machado 1 , J. J. Nassaralla 2 . 1 Cornea and Refractive Surgery, Instituto de Olhos de Goiania, Goiania, Brazil; 2 Retina and Vitreous, IOG, Goiania, Brazil f 4659 — B0123 A Treat and Extend Regimen Using Anti-VEGF Therapies for Central Retinal Vein Occlusion. Christopher J. Brady, R. Alshareef, A. J. Witkin, C. D. Regillo. Wills Eye Institute, Jefferson Univ School of Medicine, Philadelphia, PA *CR 4660 — B0124 In vitro studies on the antiangiogenic effects of Pigment Epithelium Derived Factor and Somatostatin. Anna Salas Torras, A. R. Carvalho, I. Abasolo, M. A. Zapata, L. N. Distefano, S. Schwartz, J. Garcia-Arumi. Ophthalmology, Vall d’Hebron Research Inst, Barcelona, Spain 4661 — B0125 Our experience with Sequential treatment of macular oedema from retinal vascular occlusions with anti-VEGF agents and Ozurdex. Evangelia Papavasileiou, A. Grixti, V. Kumar, S. Prasad. Eye Treatment Centre, Arrowe Park University Hospital, London, United Kingdom *CR 4662 — B0126 Short Term Ocular Response of retinal blood flow to intravitreal injection of bevacizumab (Avastin○R) treatment in eyes with central retinal vein occlusion. Seung W. Lee. Ophthalmology, Dongguk Unv, Gyeongju Hosp, Gyeongju, Republic of Korea 4663 — B0127 The Effect of Diluted Sterile Penetration Enhancer Solution in Nebulized Mist and Liquid Drop Forms on Ocular Circulation in Patients with Diabetic Retinopathy. Lina Krepste 1 , A. Harris 2 , I. Januleviciene 1 , V. J. Balciuniene 1 , L. Siaudvytyte 1 , R. Barsauskaite 1 , A. L. Gerber 2 , B. Siesky 2 . 1 Eye Clinic, Lithuanian University of Health Sciences, Kaunas, Lithuania; 2 Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN *CR, f 4664 — B0128 Measurement of Retinal Blood Flow Velocity Using a Newly Developed Doppler Fourier-Domain Optical Coherence Tomography Instruments in Humans. Akitoshi Yoshida, T. Nagaoka, T. Tani, E. Sato, T. Yoshioka, K. Sogawa, S. Nakabayashi. Ophthalmology, Asahikawa Medical University, Asahikawa, Japan 4665 — B0129 Mechanisms of retinal venous pulsation inferred from diameter waveforms analysis. Fabrice Moret 1 , W. Lagreze 2 , C. M. Poloschek 1, 2 , M. Bach 1 . 1 Sect. Visual Function and Electrophys, Eye Hospital, University of Freiburg, Freiburg, Germany; 2 Sect. Neuroophthalmology, Eye Hospital, University of Freiburg, Freiburg, Germany *CR 4666 — B0130 Effect of Nitric Oxide on Increased Retinal Blood Flow in Response to Flicker Stimuli in Cats. Takafumi Yoshioka, T. Nagaoka, A. Yoshida. Ophthalmology, Asahikawa Medical University, Asahikawa, Japan The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 302
Wednesday – Posters – 4667 – 4686 4667 — B0131 Measurement Of Retinal Blood Flow and Retinal Oxygen Tension During Acute Decreasing Systemic Blood Pressure In Cats. Tomofumi Tani, T. Nagaoka, T. Yoshioka, A. Yoshida. Ophthalmology, Asahikawa Medical University, Asahikawa, Japan 4668 — B0132 Measurement of Retinal Blood Flow Using a Newly Developed Doppler Fourier-Domain Optical Coherence Tomography Instruments in Cats. Taiji Nagaoka, T. Tani, E. Sato, T. Yoshioka, K. Sogawa, S. Nakabayashi, A. Yoshida. Ophthalmology, Asahikawa Medical University, Asahikawa, Japan 4669 — B0133 Development of a prototype of laser Doppler flowmeter for the measurement of blood flow of retinal vessels and optic nerve head tissue in small animals (rats). Marielle Mentek 1 , C. Chiquet 3, 1 , F. Truffer 2 , M. Bernabei 2 , B. Mottet 3 , J. Romanet 3 , D. Godin-Ribuot 1 , M. Geiser 2 . 1 INSERM U1042, Grenoble, France; 2 Institute of system engineering, University of Applied Sciences of Western Switzerland, Sion, Switzerland; 3 Ophthalmology department, CHU Grenoble, Joseph Fourier University, Grenoble, France 4670 — B0134 Retinal blood velocity significantly decreased in rhegmatogenous retinal detachment and recovered after surgical treatment in both artery and vein. Hirofumi Kinoshita, K. Suzuma, M. Uematsu, R. Ueki, T. Kitaoka. Nagasaki Univ School of Medicine, Nagasaki, Japan 4671 — B0135 Ocular rigidity as estimated based on measurement of pulse amplitude using pneumotonometry and fundus pulse is dependent on intraocular pressure. Anton B. Hommer 1, 2 , G. Garhofer 2 , L. Schmetterer 2 . 1 Krankenhaus Hera Vienna, Vienna, Austria; 2 Dep.of. Clinical Pharmacology, University Clinic, Vienna, Austria *CR 4672 — B0136 Sphingosine 1-phosphate elicits constriction of isolated porcine retinal arterioles. Takayuki Kamiya, T. Nagaoka, T. Omae, S. Ono, A. Yoshida. Asahikawa Medical University, Asahikawa, Japan *CR 4673 — B0137 Ocular Pulse Amplitude Waveform Reflects Ventricular Bigeminy and Aortic Insufficiency. Jean B. Kassem 1, 2 , S. E. Katz 1, 2 , C. J. Roberts 2, 3 , A. M. Mahmoud 2, 3 , R. H. Small 4, 3 , S. V. Raman 5, 3 . 1 Neuro-Orbit- Oculoplastics, Havener Eye Institute, Columbus, OH; 2 Ophthalmology, The Ohio State University, Columbus, OH; 3 Biomedical Engineering, The Ohio State University, Columbus, OH; 4 Anesthesiology, The Ohio State University, Columbus, OH; 5 Cardiovascular Medicine, The Ohio State University, Columbus, OH *CR Exhibit Hall B0243-B0273 Wednesday, May 08, 2013 11:00 AM-12:45 PM Nanotechnology and Regenerative Medicine 439 Ocular Nanoimaging, Nanobiosensors and Nanodiagnostics Moderators: Yolanda Diebold and Stephen H. Tsang 4674 — B0243 Functional rescue for a full year after gene therapy in a pre-clinical model of retinitis pigmentosa. Katherine J. Wert 1, 2 , R. J. Davis 1 , J. Sancho-Pelluz 1 , C. Lin 1 , S. H. Tsang 1, 3 . 1 Ophthalmology, Columbia University, New York, NY; 2 Institute of Human Nutrition, Columbia University, New York, NY; 3 Pathology & Cell Biology, Columbia University, New York, NY 4675 — B0244 The effect of nano-structural hydroxyapatite on the biocompatibity of artificial cornea skirt material in vitro and in vivo. Ying Dong 1, 2 , L. Wang 2 , J. Yang 3 , Y. Huang 2 , F. Cui 3 . 1 Department of Ophthalmology, First Hospital Affiliated to Chinese PLA General Hospital, Beijing, China; 2 Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China; 3 Department of Material Science and Engineering, Tsinghua University, Beijing, China 4676 — B0245 Formulation of a Biocompatible Photopolymerizable Gel to Prevent the Oxiative Damage of the Crystalline Lens. Tongalp H. Tezel 1, 2 , Q. Zeng 1 , M. G. O’Toole 3 , A. S. Gobin 3 . 1 Ophthal & Vis Sciences, University of Louisville, Louisville, KY; 2 Anatomy and Neurobiology, University of Louisville, Louisville, KY; 3 Bioengineering, University of Louisville, Louisville, KY *CR 4677 — B0246 Efficacy of a novel bioengineered corneal stroma fabricated by a new biocompatible cross linker in corneal stromal disease model. Takeshi Soma 1 , M. Matsusaki 2 , M. Matsumoto 2 , H. Ajiro 2 , M. Tsujikawa 1 , R. Hayashi 1 , Y. Oie 1 , M. Akashi 2 , K. Nishida 1 . 1 Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan; 2 Department of Applied Chemistry, Osaka University Graduate School of Graduate School of Engineering, Suita, Japan *CR 4678 — B0247 Feasibility of 2nd Generation STS Retinal Prosthesis with 49 Channel Electrode Array in Dogs. Takashi Fujikado 1, 2 , M. Kamei 2 , H. Sakaguchi 2 , H. Kanda 1 , T. Morimoto 1, 2 , K. Nishida 2 , H. Kishima 3 , T. Maruo 3 , K. Osawa 4 , M. Ozawa 4 . 1 Applied Visual Science, Osaka University, Suita, Japan; 2 Ophthalmology, Osaka University, Suita, Japan; 3 Neurosurgery, Osaka University, Suita, Japan; 4 Vision Institute, Nidek Co., Gamagori, Japan *CR 4679 — B0248 Air transport system of oral mucosal tissue and cell sheets for clinical trial. Yoshinori Oie 1 , S. Andojo 1 , N. Konno 1 , H. Takayanagi 2 , T. Nozaki 3 , S. Takeda 3 , T. Soma 1 , M. Tsujikawa 1 , K. Nishida 1 . 1 Ophthalmology, Osaka University, Suita, Japan; 2 Translational Research Center, Tohoku Univeristy, Sendai, Japan; 3 Central Research Laboratory, Hitachi, Tokyo, Japan *CR 4680 — B0249 Fullerenol Protects RPE cells from Oxidative-stress Induced Premature Senescence via Activation of SIRT1. Guo-Tong Xu 1, 2 , C. Zhuge 1 , J. Xu 2, 3 , J. Zhang 2, 3 , G. Xu 4 , L. Chen 2, 3 , X. Liu 2, 3 , H. Xu 2, 3 , L. Lu 2, 3 , W. Li 5 . 1 Laboratory of Clinical Visual Science, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; 2 Ophthal, Regenerativie Med, Tongji Univ School of Medicine, Shanghai, China; 3 Department of Regenerative Medicine and Stem Cell Research Center, Tongji University School of Medicine, Shanghai, China; 4 Department of Ophthalmology, Second Affiliated Hospital, Suzhou University, Suzhou, China; 5 Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA 4681 — B0250 Reconstruction of Conjunctival Epithelium with Goblet Cells by Collagen Vitrigel. Huifang Zhou 1, 2 , Q. Guo 1 , M. Grant 3 , J. Elisseeff 1 . 1 Translational Tissue Engineering Center, Wilmer Eye Institute and Biomedical Engineering, Baltimore, MD; 2 Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 3 Oculoplastics Division, Ocular and Orbital Trauma Center, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD *CR 4682 — B0251 Overall visual performance is well described by three independent measures in Argus ® II subjects. Thomas Z. Lauritzen 1 , A. Das 1, 2 , J. D. Dorn 1 , R. J. Greenberg 1 . 1 Second Sight Med Products, Inc, Sylmar, CA; 2 Dept. of Physics, USC, Los Angeles, CA *CR, f 4683 — B0252 Excimer Ablation of Collagen- Based Corneal Substitutes. Silvia Odorcic 1 , C. Noel 1 , D. Mitra 1 , D. Priest 1 , S. Taylor 1 , M. Griffith 2 , R. Munger 1 , W. Jackson 1 . 1 The Ottawa Hospital, Ottawa, ON, Canada; 2 Linköping University, Linköping, Sweden *CR 4684 — B0253 Human retinal progenitor cells as a tool for retinal repair: establishing cell lines for clinical study. Petr Y. Baranov 1 , G. Brooke 2 , S. Patel 2 , M. J. Young 1 , J. Sinden 2 . 1 Schepens Eye Research Institute, Boston, MA; 2 ReNeuron Ltd., Guildford, United Kingdom *CR 4685 — B0254 Hybrid vitronectin-mimicking polycaprolactone scaffolds and human retinal progenitor cell composites. Elodie Lawley 1, 2 , P. Y. Baranov 1 , M. J. Young 1 . 1 Opthamology, Schepens Eye Research Institute, Massachusetts Eye and Ear, an affiliate of Harvard Medical School, Boston, MA; 2 Exeter Medical School, Exeter, United Kingdom *CR 4686 — B0255 Stem Cell and Encapsulated Drug Delivery to the Inner Retina using a Fibrin Polymer Spray System. Hari Jayaram 1, 2 , M. F. Jones 2 , R. M. Day 3 , P. B. Cottrill 2 , K. Eastlake 2 , S. Becker 2 , G. Limb 2 . 1 NIHR Biomedical Research Centre for Ophthalmology, UCL Institute of Ophthalmology & Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom; 2 Ocular Biology & Therapeutics, UCL Insitute of Ophthalmology, London, United Kingdom; 3 Applied Biomedical Engineering, University College London, London, United Kingdom *CR Wednesday Posters 11:00 am – 12:45 pm f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 303
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Wednesday - ARVO

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