Wednesday - ARVO

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4597 – 4618 – Wednesday – Posters Wednesday Posters 11:00 am – 12:45 pm 4597 — A0148 Overactive Arginase Causes Mitochondrial Dysfunction and Premature Endothelial Cell Senescence during Diabetic Retinopathy. Ruth B. Caldwell 1, 3 , S. Narayanan 1 , M. A. Rojas 1 , T. Lemtalsi 1 , Z. Xu 1 , K. Jittiporn 1 , E. Schenhals 1 , R. W. Caldwell 2 , D. J. Fulton 1, 2 . 1 Vascular Biology Center, Georgia Health Sciences University, Augusta, GA; 2 Department of Pharmacology & Toxicology, Georgia Health Sciences University, Augusta, GA; 3 Charlie Norwood VA Medical Center, Augusta, GA 4598 — A0149 Potential beneficial effects of carotenoids on diabetic retinopathy. Renu A. Kowluru 1 , Q. Zhong 1 , J. M. Santos 1 , M. ThandampallayamAjje 1 , D. Putt 1 , D. L. Gierhart 2 . 1 Ophthalmology, Wayne State Univ/Kresge Eye Inst, Detroit, MI; 2 Zeavision, L.L.C, Chesterfield, MO *CR 4599 — A0150 The Impact on Vision and Regression of Retinal Neovascularization of Anti- VEGF Induction in Combination with Quarterly Anti-VEGF Maintenance or Selective PRP versus Standard PRP. Victor H. Gonzalez. Valley Retina Institute PA, Harlingen, TX *CR, f 4600 — A0151 Matrix metalloproteinase-9 regulates angiogenic and vasculogenic factors in diabetic retina. Ghulam Mohammad, A. Abu El-Asrar. Ophthalmology, king Saud University, Riyadh, Saudi Arabia 4601 — A0152 Subtoxic Dosage of Methylglyoxal Stimulated Production of Urokinase-Type Plasminogen Activator by Retinal Pigment Epithelial Cells. Anthony Sclafani 1 , D. Hu 1, 2 , T. Vagaggini 1 , S. A. McCormick 1, 2 . 1 The NY Eye & Ear Infirmary, New York, NY; 2 New York Medical College, Valhalla, NY *CR 4602 — A0153 microRNA-30a Antagonism Inhibits Ras Signaling and Prevents Neovascularization. Carli M. Wittgrove, P. D. Westenskow, T. Kurihara, E. Aguilar, S. K. Moreno, M. Friedlander. Cell Biology, The Scripps Research Institute, La Jolla, CA 4603 — A0154 Ranibizumab and Bevacizumab Decrease Macular Ganglion Cell Complex (GCC) Thickness Measured with Fourier- Domain Optical Coherence Tomography in Age- Related Macular Degeneration (AMD). Nalin J. Mehta 1 , H. Quiroz-Mercado 2, 3 , M. J. Sinai 6 , K. A. Soules 4 , A. N. Mehta 5 , S. Schwartz 2, 3 . 1 Colorado Retina Center, Lakewood, CO; 2 Department of Ophthalmology, Denver Health Medical Center, Denver, CO; 3 Department of Ophthalmology, University of Colorado, Denver, CO; 4 Optovue Inc., Fremont, CA; 5 Colorado Academy, Denver, CO; 6 formerly Optovue Inc., Fremont, CA *CR 4604 — A0155 A new mouse model of dry form AMD. Haoyu Mao, A. S. Lewin, M. Conners. Molecular Genetics and Microbiology, University of Florida, Gainesville, FL *CR 4605 — A0156 Serine/Arginine-Rich Protein Kinase Blockade Attenuates Choroidal Neovascularization. Zhenyu Dong 1, 2 , K. Noda 1, 2 , A. Kanda 1, 2 , J. Fukuhara 1, 2 , R. Ando 1, 2 , M. Murata 1, 2 , W. Saito 2 , M. Hagiwara 3 , S. Ishida 1, 2 . 1 Laboratory of Ocular Cell Biology and Visual Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 2 Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 3 Department of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan *CR 4606 — A0157 Osteopontin (OPN) is Present in Drusen and Basal Deposits in Human Eyes with Age-Related Macular Degeneration (AMD). Amanda Bednar, M. Choudhary, P. Saloupis, A. D. Proia, G. Malek. Opthamology, Duke University, Durham, NC 4607 — A0158 The Role of Abnormal Blood Flow in Age-Related Macular Degeneration. Luis Alarcon-Martinez 1, 2 , H. Rieiro 1 , T. Demirci 1 , R. Leal-Campanario 1, 3 , S. Martinez-Conde 1 , S. L. Macknik 1 . 1 Neurobiology, Barrow Neurological Institute, Phoenix, AZ; 2 Ophthalmology, University of Murcia, Murcia, Spain; 3 División de Neurociencias, Universidad Pablo de Olavide, Sevilla, Spain 4608 — A0159 RPE, Bruch’s membrane changes in rabbit eyes and a human eye with retinal photoxicity. Mehmet Koray Sevinc 1 , U. Erdem 1 , A. Kubar 2 , E. Oztas 3 . 1 Ophthalmology, Gülhane Military Medical Faculty, Ankara, Turkey; 2 Microbiology, Gülhane Military Medical Faculty, Ankara, Turkey; 3 Histology, Gülhane Military Medical Faculty, Ankara, Turkey 4609 — A0160 Inflammatory monocytes accumulate in atrophic age-related macular degeneration. Sophie Lavalette 1, 2 , S. Camelo 3, 4 , O. Levy 1, 2 , W. Raoul 1, 2 , B. Calippe 1, 2 , X. P. Guillonneau 1, 2 , C. Combadière 5, 6 , F. Sennlaub 1, 2 . 1 INSERM,U968, Paris, France; 2 UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris, France; 3 INSERM, UMR_S 872, Centre de Recherche des Cordeliers, Paris, France; 4 UPMC Univ Paris 06, UMR_S 872, Paris, France; 5 INSERM UMR_S 945, Laboratoire d’Immunologie Cellulaire, Paris, France; 6 UPMC Univ Paris 06, UMR_S 945, Paris, France 4610 — A0161 Cell growth inhibtion in HPV 18 positive uveal melanoma cells by E6/E7 siRNA. Xianqun Fan, R. Jia. Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 4611 — A0162 Aflibercept is internalized by retinal microvascular endothelial cells. Heidrun L. Deissler, G. E. Lang. Department of Ophthalmology, University of Ulm, Ulm, Germany *CR 4612 — A0163 Therapeutic Efficacy of Adipose Stromal Cells to Protect the Retinal Neurons and Vasculature in Rat Retinal Ischemia-reperfusion Injury Model. Chandrika Abburi 1 , A. J. Cantor 1 , S. Caballero 5 , R. Maturi 3, 1 , T. S. Kern 4 , M. B. Grant 5 , K. L. March 2 , G. Rajashekhar 1, 2 . 1 Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana Univ., Indianapolis, IN; 2 Indiana Center for Vascular Biology & Medicine, Indianapolis, IN; 3 Midwest Eye Institute, Indianapolis, IN; 4 Ophthalmology, Case Western Reserve University, Cleveland, OH; 5 Pharmacology and Therapeutics, University of Florida, Gainesville, FL *CR 4613 — A0164 Lp-PLA 2 is a potential therapeutic target in diabetic macula edema. Paul Canning 1 , J. V. Glenn 1 , V. Prise 1 , D. C. Gale 2 , A. W. Stitt 1 , P. S. Adamson 3 . 1 Centre of Vision & Vascular Science, Queens University Belfast, Belfast, United Kingdom; 2 Ophthalmology Discovery Performance Unit, GlaxoSmithKline, King of Prussia, PA; 3 Ophthalmology Discovery Performance Unit, GlaxoSmithKline, Stevenage, United Kingdom *CR 4614 — A0165 Differential impairment of rod and cone pathways in streptozotocin-induced diabetic mice. Ilaria Piano 1 , A. Caputo 2 , E. Novelli 1 , L. A. Cervetto 2 , C. M. Gargini 2 . 1 IRCCS- G.B. Bietti Foundation for Ophthalmology Research, Rome, Italy; 2 Pharmacy, University of Pisa, Pisa, Italy 4615 — A0166 Comparative Ocular Tissue Distribution Kinetics of the Visual Cycle Modulator (VCM) Emixustat-HCl in Rats, Beagle Dogs, and Cynomolgus Monkeys. Terry Podoll 1 , S. Al-Fayoumi 1 , E. Prescott 2 , J. W. Chandler 1 , R. Kubota 1 . 1 Acucela Inc, Seattle, WA; 2 Covance Laboratories Inc, Madison, WI *CR 4616 — A0167 Systemic erythropoietin and its role in diabetic retinopathy. Sofija Davidovic 1 , S. Latinovic 2 . 1 Department for vitreoretinal diseases, University Eye Clinic Clinical Center Vojvodina, Novi Sad, Serbia; 2 VIDAR ORASIS- Swiss, Private Eye hospital, Novi Sad, Serbia 4617 — A0168 Chemical Screens in Zebrafish Identify Novel Inhibitors of Retinal Neovascularisation in Mouse. Breandan N. Kennedy 1 , Y. Alvarez 1 , M. Tosetto 2 , C. Kilty 1 , T. Sasore 1 , C. M. McVicar 3 , A. W. Stitt 3 , J. O’Sullivan 4 , A. L. Reynolds 1 . 1 UCD School of Biomolecular and Biomedical Science & UCD Conway Institute, University College Dublin, Dublin, Ireland; 2 St. Vincent’s University Hospital, University College Dublin, Dublin, Ireland; 3 Centre for Vision and Vascular Science, Queen’s University, Belfast, United Kingdom; 4 Department of Surgery, Trinity College Dublin, Dublin, Ireland *CR 4618 — A0169 Evaluation of Antiangiogenic Effect of Sintetic Small Fragments of PEDF. Andrea R. Carvalho, J. Badal, M. A. Zapata, A. Salas Torras, L. N. Distefano, J. Garcia-Arumi. Ophthalmology, Inst de Recerca Hosp Vall d’Hebron, Barcelona, Spain The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 300
Wednesday – Posters – 4619 – 4641 4619 — A0170 A novel Erythropoietin-derived peptide regulates Endothelial Progenitor Cell (EPC) mediated retinal vasorepair. Olivia E. O’Leary 1 , E. Reid 1 , C. M. McVicar 1 , M. Brines 2 , A. Cerami 2 , R. J. Medina 1 , D. P. Brazil 1 , A. W. Stitt 1 . 1 Centre for Vision and Vascular Science, Queen’s University Belfast, Belfast, United Kingdom; 2 Warren Pharmaceuticals, Ossining, NY *CR 4620 — A0171 Effect of HMG-CoA reductase inhibitor(statins) on the expression of catalase in human retinal pigment epithelial cells. Min Gu Kang, S. Lee, N. Kim, H. Chin. Department of Ophthalmology and Inha Vision Science Laboratory, Inha University School of Medicine, Incheon, Republic of Korea 4621 — A0172 Resveratrol suppresses the VEGF expression by inhibition of the CXCR4 Expression in ARPE-19 cells. Inyoung Chung 1 , H. Seong 2 , S. Kang 2 , J. Park 1 , S. Seo 1 . 1 Ophthalmology, School of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju-si, Republic of Korea; 2 Anatomy and Neurobiology, School of Medicine, Institute of Health Sciences, Medical Research Center for Neural Dysfunction, Gyeongsang National University, Jinju-si, Republic of Korea 4622 — A0173 Antiangiogenic Effect of Quercetin on Laser-Induced Choroidal Neovascularization in Mice. Junichi Fukuhara 1, 2 , K. Noda 1, 2 , S. Takashina 1, 2 , Y. Dong 1, 2 , S. Kinoshita 1, 2 , Z. Dong 1, 2 , R. Ando 1, 2 , A. Kanda 1, 2 , S. Ishida 1, 2 . 1 Laboratory of Ocular Cell Biology and Visual Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 2 Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan 4623 — A0174 Genistein Suppresses Laser- Induced Choroidal Neovascularization in Mice. Satoshi Kinoshita 1, 2 , K. Noda 1, 2 , S. Takashina 1, 2 , Y. Dong 1, 2 , J. Fukuhara 1, 2 , Z. Dong 1, 2 , R. Ando 1, 2 , A. Kanda 1, 2 , S. Ishida 1, 2 . 1 Laboratory of Ocular Cell Biology and Visual Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 2 Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan 4624 — A0175 Inhibition of Laser-induced Choroidal Neovascularization by Macrolactin Compounds. Sang Jin Kim 1 , J. Kim 1 , D. Kim 2 . 1 Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; 2 Research and Development Center, Daewoo Pharm. Co. Ltd., Busan, Republic of Korea *CR 4625 — A0176 Inhibition of choroidal neovascularization by neutralizing PDGF with a recombinant fusion protein of PDGFR β domain. Yiwen Li 1 , W. Tao 2 , V. Ling 2 , A. Nystuen 2 , S. A. Elliott 2 , P. Stabila 2 , R. Wen 1 . 1 Bascom Palmer Eye Institute, University of Miami, Miami, FL; 2 Neurotech USA, Lincoln, RI *CR 4626 — A0177 One-year Results of Intravitreal Ranibizumab Combined with Reduced-Fluence Photodynamic Therapy for Polypoidal Choroidal Vasculopathy. Daisuke Yamanouchi, M. Sakurai, T. Baba, M. Kitahashi, H. Yokouchi, M. Kubota- Taniai, S. Yamamoto. Chiba univercity, Chiba, Japan 4627 — A0178 NIPAAm Based Cell Delivery Scaffolds for Posterior Segment Therapeutics. Ben Muirhead 1 , S. D. Fitzpatrick 1 , K. Gregory- Evans 2 , M. Bhatia 1 , H. Sheardown 1 . 1 Biomedical Engineering, McMaster University, Elmira, ON, Canada; 2 Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada *CR Exhibit Hall B0092-B0137 Wednesday, May 08, 2013 11:00 AM-12:45 PM Physiology/Pharmacology / Retinal Cell Biology 438 Retinal Flow and VEGF Moderators: Michele Reibaldi and Tonia S. Rex 4628 — B0092 Subfoveal Choroidal blood flow in senescence. John V. Lovasik, H. Kergoat, M. Parent. School of Optometry, University of Montreal, Montreal, QC, Canada 4629 — B0093 Time-dependent intracellular pattern of Bevacizumab in RPE cells. Shereen Hassan M. Aboul Naga 1, 2 , M. Dithmer 1 , J. Roider 1 , A. K. Klettner 1 . 1 Ophthalmology, University of Kiel, University Medical Centre, Kiel, Germany; 2 Ophthalmology, Kasr Al Aini, Cairo University Hospitals, Cairo, Egypt *CR 4630 — B0094 Antagonism of PDGFRβ Inhibits Pericyte Recruitment in a Mouse Model of Corneal Neovascularization. Amy Jensen 1 , R. Cepeda 1 , M. Maker 1 , C. E. Bigelow 1 , J. Ghosh 1 , G. Li 1 , P. A. D’Amore 2 , G. Spohn 1 , B. D. Jaffee 1 , S. Azarian 1 . 1 Ophthalmology, Novartis, Cambridge, MA; 2 Ophthalmology, Schepens Eye Research Institute, Boston, MA *CR 4631 — B0095 Dynamic retinal venous oscillations are changed in diabetes mellitus type 1. Konstantin E. Kotliar 1, 2 , I. M. Lanzl 2 , T. Siegmund 4 , A. Schmidt-Trucksaess 5, 3 . 1 Biomedical Engineering, Aachen University of Applied Sciences, Juelich, Germany; 2 Ophthalmology, Munich University of Technology, Munich, Germany; 3 Preventive Sports Medicine, Munich University of Technology, Munich, Germany; 4 Endocrinology and Diabetes, Bogenhausen Hospital, Munich, Germany; 5 Division of Sports Medicine, University of Basel, Basel, Switzerland *CR 4632 — B0096 Parameters related to Choroidal thickness. Yasuki Ito 1 , K. Oiwa 1 , E. Iwata 1 , A. Takahashi 1 , T. Yasuma 1 , K. Kawano 1 , N. Hamajima 2 , H. Terasaki 1 . 1 Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 2 Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan 4633 — B0097 Blockade of PGF/VEGFR1 signaling significantly prevents BRB breakdown, apoptosis and inflammation in diabetic retinopathy. Hu Huang, D. Johnson, D. Kim, G. A. Lutty. Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, MD f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 301 4634 — B0098 Computational Model of Oxygen Transport in Retina and Optic Nerve. David Bragason 1 , E. Stefánsson 1, 2 . 1 Ophthalmology, Landspitali University Hospital, Reykjavik, Iceland; 2 Medicine, University of Iceland, Reykjavik, Iceland *CR 4635 — B0099 Increased Retinal Vascular Tortuosity in Obstructive Sleep Apnea. Amir Mohsenin 1 , V. Mohsenin 2 , R. A. Adelman 1 . 1 Department of Ophthalmology, Yale University School of Med, New Haven, CT; 2 Yale Center for Sleep Medicine, Yale University School of Medicine, New Haven, CT 4636 — B0100 Oxygen saturation in retinal hemorrhages. Olafur Palsson 1, 2 , S. H. Hardarson 1, 2 , T. S. Eliasdottir 2 , E. Stefánsson 1, 2 . 1 Department of Ophthalmology, Landspítali University Hospital, Reykjavik, Iceland; 2 University of Iceland, Reykjavik, Iceland *CR 4637 — B0101 Assessment of Total Retinal Blood Flow under Systemic Hypercapnia and Hypocapnia. Ayda M. Shahidi 1 , S. R. Patel 1 , J. G. Flanagan 1, 3 , O. Tan 2 , D. Huang 2 , C. Hudson 1, 3 . 1 Ophthalmology & Vision Science, University Health Network, Toronto, ON, Canada; 2 Ophthalmology, Oregon Health and Science University, Portland, OR; 3 Optometry & Vision Science, University of Waterloo, Waterloo, ON, Canada *CR 4638 — B0102 One-year results of Central Retinal Sensitivity in eyes treated with Pegaptanib for Proliferative Diabetic Retinopathy with extended dosing. Blanca C. Flores, V. H. Gonzalez, R. Diaz-Rohena. Valley Retina Institute, McAllen, TX *CR, f 4639 — B0103 Persistent hyaloid vessels counteract insufficient retinal perfusion in the mouse eye. Christina Seide, M. Garcia Garrido, V. Sothilingam, N. Tanimoto, S. C. Beck, M. W. Seeliger. Div of Ocular Neurodegeneration, Ctr for Ophthal Inst for Ophth Rsrch, Tuebingen, Germany 4640 — B0104 Retinal Vessel Diameter at High Altitude. Gabriel Willmann 1 , A. Schatz 1 , M. Fischer 1, 3 , K. Schommer 2 , E. Zrenner 1 , K. Bartz- Schmidt 1 , F. Gekeler 1 . 1 Centre for Ophthalmology, University of Tübingen, Tübingen, Germany; 2 Department of Sports Medicine, University Hospital Heidelberg, Heidelberg, Germany; 3 Nuffield Laboratory of Ophthalmology, University of Oxford, Oxford, United Kingdom *CR 4641 — B0105 Retinal and Cerebral Oxygenation Response to Graded Hypoxia. Sunni R. Patel 1 , C. Hudson 2, 3 , A. M. Shahidi 1 , S. Kulasekara 2 , J. Fisher 4 , J. G. Flanagan 2, 3 , W. Mutch 5 . 1 Ophthalmology and Vision Sciences, Toronto Western Hospital, Toronto, ON, Canada; 2 Department of Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada; 3 School of Optometry and Vision Science, University of Waterloo, Toronto, ON, Canada; 4 School of Physiology, University of Toronto, Toronto, ON, Canada; 5 Perioperative Medicine and Anaesthesiology, University of Manitoba, Winnepeg, MB, Canada *CR Wednesday Posters 11:00 am – 12:45 pm
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Wednesday - ARVO

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