4575 – <strong>Wednesday</strong> – Papers/Minisymposium 4575 — 12:30 A Phase I Open Label, Dose Escalation Trial Of QPI-1007 Delivered By A Single Intravitreal (IVT) Injection To Subjects With Low Visual Acuity And Acute Non- Arteritic Anterior Ischemic Optic Neuropathy (NAION). Andrew N. Antoszyk 1, 2 , B. Katz 3 , R. Singh 4 , R. Gurses-Ozden 5 , S. S. Erlich 5 , D. Rothenstein 5 , N. Sharon 5 , J. Hodge 5 , L. A. Levin 6, 7 , N. R. Miller 8 . 1 Retina, Charlotte EEN&T Associates, Charlotte, NC; 2 Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD; 3 Ophthalmology and Visual Sciences, University of Utah Health Sciences Center, Salt Lake City, UT; 4 Ophthalmology, Cleveland Clinic Foundation, Cleveland, OH; 5 Quark Pharmaceuticals, Inc., Fremont, CA; 6 Ophthalmology, McGill University, Montreal, QC, Canada; 7 Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI; 8 Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD *CR, f <strong>Wednesday</strong> Papers/ Minisymposium 11:00 am – 12:45 pm The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 298
<strong>Wednesday</strong> – Posters – 4576 – 4596 Exhibit Hall A0095-A0113 <strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM Biochemistry/Molecular Biology 436 AMD I, BI Moderator: Aparna Lakkaraju 4576 — A0095 Autophagy disregulation in the retina during aging and neurodegeneration. Enrique J. de la Rosa 1 , N. Rodriguez-Muela 2 , H. Koga 3 , L. Garcia-Ledo 2 , P. de la Villa 4 , A. M. Cuervo 3 , P. Boya 2 . 1 Cell & Molecular Medicine, Centro de Investigaciones Biologicas, Madrid, Spain; 2 Cell & Molecular Biology, Centro de Investigaciones Biologicas CSIC, Madrid, Spain; 3 Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY; 4 Physiology, School of Medicine, University of Alcala, Alcala de Henares, Spain *CR 4577 — A0096 High glucose activates ChREBP-mediated HIF-1α and VEGF expression in human RPE cells under normoxia. Min-Lee Chang, C. Chiu, F. Shang, A. Taylor. HNRCA Tufts University, Boston, MA 4578 — A0097 AMD-associated silent polymorphisms in HtrA1 ameliorate IGF-1 antagonism. Sarah Melissa P. Jacobo 1, 2 , M. M. DeAngelis 3, 4 , A. Kazlauskas 1, 2 . 1 Ophthalmology, Harvard Medical School, Boston, MA; 2 The Schepens Eye Research Institute, Boston, MA; 3 Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT; 4 John A. Moran Eye Center, Salt Lake City, UT 4579 — A0098 Differences in Reactive Oxygen Species (ROS) Production and Expression of Genes from the Complement and Inflammatory Pathways Between H and K Haplogroup Cybrids. Javier Cáceres del Carpio 1 , M. Tarek 1 , C. A. Ramirez 1 , P. Falatoonzadeh 1 , M. Chwa 1 , D. Malik 1 , S. Jazwinski 2 , M. V. Michael 2 , B. D. Kuppermann 1 , C. M. Kenney 1 . 1 Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA; 2 Tulane Center for Aging, Tulane University, New Orleans, LA *CR 4580 — A0099 Stimulation of Semaphorin3E/ PlexinD1 pathway has anti-angiogenic effect in experimental model of choroidal neovascularization. Kenji Suda, C. Guo, A. Oishi, S. Ikeda, N. Yoshimura. Ophthalmology, Kyoto University, Kyoto, Japan *CR 4581 — A0100 Adiponectin Peptide II (APNpII) effect on human ARPE-19 cells. Puran S. Bora, N. S. Bora, V. V. Lyzogubov. Ophthalmology, Jones Eye Institute-UAMS, Little Rock, AR 4582 — A0101 Isoform-specific interactions between human apolipoprotein E and amyloidbeta in the retinal pigment epithelium. Kimberly A. Toops, J. Xu, A. Lakkaraju. Ophthalmology and Visual Sciences, University of Wisconsin - Madison, Madison, WI 4583 — A0102 Effects of the absence of both complement factor H and apolipoprotein E on VEGF expression, MMP2/9 activity and caspase-1. Laura Garcia-Garcia, P. Fernandez, S. Recalde, M. Moreno-Orduña, V. Fernandez-Garcia, A. Garcia-Layana. Ophthalmology Experimental Laboratory, Clinica Universidad de Navarra, Pamplona, Spain 4584 — A0103 Surface plasmon resonance indicates that complement factor H, C3b and native properdin bind to carboxyethylpyrroleadducted BSA. Lisa Kuttner-Kondo 1 , V. P. Ferreira 2 , C. Cortes 2 , S. P. Yadav 3 , J. G. Hollyfield 1 . 1 Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH; 2 Dept. of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, OH; 3 Molecular Biotechnology Core, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 4585 — A0104 The aging retina: Macula-less rat and macula-bearing monkey retinae exhibit common age-related changes in their retinal proteins. Michael R. Boehm 1, 2 , S. Mertsch 1 , H. Melkonyan 1 , S. Thanos 1 . 1 Institute for Experimental Ophthalmology, School of Medicine, WWU Muenster, Muenster, Germany; 2 Current Affiliation: Department of Ophthalmology, University of Muenster Medical Center, Muenster, Germany 4586 — A0105 Gene expression profile of Retinal Pigment Epithelium derived ARPE- 19 cells under serum starvation. Sanghamitra Mishra 1 , K. M. Peterson 1 , A. E. Berger 2 , G. J. Wistow 1 . 1 Section for Molecular Structure and Functional Genomics, National Eye Institute, Bethesda, MD; 2 JHBMC Lowe Family Genomics Core, Johns Hopkins University - School of Medicine, Baltimore, MD 4587 — A0106 HSPA5 - a possible new contributing gene in atrophic age-related macular degeneration. Sumana Chintalapudi, Y. H. Chan Lau, S. Sahu, M. M. Jablonski. Ophthalmology, The University of Tennessee Health Science Center, Memphis, TN *CR 4588 — A0107 Quercetin Inhibits H2O2 Stimulated PEDF and FGF2 Synthesis in hRPE Cells. Nandita Anand, P. C. Kothary, M. A. Del Monte. University of Michigan, Ann Arbor, MI 4589 — A0108 AMD-like phenotypes in transgenic mice over-expressing BMP4 in RPE. Danhong Zhu 1 , J. Xu 1 , X. Deng 1 , J. Hsiung 1 , S. J. Ryan 2 , D. R. Hinton 1, 2 . 1 Pathology, University of Southern California, Los Angeles, CA; 2 ophthalmology, University of Southern California, Los Angeles, CA *CR 4590 — A0109 Vitamin D Status and Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration. Amardeep Singh 1, 2 , M. K. Falk 1, 2 , Y. Subhi 1, 2 , T. L. Sørensen 1, 2 . 1 Ophthalmology, Copenhagen University Hospital Roskilde, Roskilde, Denmark; 2 University of Copenhagen, Copenhagen, Denmark 4591 — A0110 Cd46 -/- Mouse as a Model of Dry-type Age-related Macular Degeneration. Valeriy V. Lyzogubov 1 , X. Wu 2 , G. Kolar 2 , P. S. Bora 1 , J. P. Atkinson 2 , N. S. Bora 1 . 1 Ophthalmology, Jones Eye Institute - UAMS, Little Rock, AR; 2 Department of Medicine, Washington University School of Medicine, St. Louis, MO 4592 — A0111 Tissue Inhibitor of Metalloproteinase-3 (TIMP3) Induces Endothelial Apoptosis via MMP- and Caspase- Independent Mechanisms. Jian H. Qi, B. Anand- Apte. Ophthalmic Research-ColeEye Inst, Cole Eye Institute, Cleveland, OH *CR 4593 — A0112 Localization of mechanotransduction channels in the trabecular meshwork of glaucomatous DBA/2J mice. Phi Ho, V. T. Tran, L. Cabrera, S. K. Bhattacharya. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 4594 — A0113 CTRP5 over-expression in RPE cells leads to loss of RPE cell adhesion and retinal degeneration in wild-type mice. Astra Dinculescu 1 , S. Min 1 , W. Deng 1 , J. Li 1 , R. C. Ryals 1 , R. M. Stupay 1 , P. Zhu 1 , B. Sahu 2 , R. Ayyagari 2 , W. W. Hauswirth 1 . 1 Ophthalmology, University of Florida, Gainesville, FL; 2 Shiely Eye Center, University of California, San Diego, La Jolla, CA *CR Exhibit Hall A0146-A0178 <strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM Retinal Cell Biology 437 Translational Approaches in AMD and DR Moderators: Ruth B. Caldwell and Alfred S. Lewin 4595 — A0146 Not age but the rate of aging drives the pathogenesis of age related macular degeneration in primates. Peter Gouras 1 , L. Ivert 2 , M. Neuringer 3 , J. Mattison 4 . 1 Ophthalmology/Eye Institute, Columbia University, New York, NY; 2 Retina S:t Eriks Eyehospital, Karolinska institute, Stockholm, Sweden; 3 Ophthalmology, Oregon Health and Science university, Beaverton, OR; 4 Experimental Gerontology, National Institute on Aging, Baltimore, MD *CR 4596 — A0147 The dual PPAR-α/γ agonist aleglitazar attenuates retinopathy in streptozotocin diabetic rats. Raul de la Flor 1 , M. B. Wright 2 , A. P. Adamis 3 , J. S. Ehrlich 3 , D. T. Shima 1 . 1 UCL Institute of Ophthalmology, London, United Kingdom; 2 Pharma Research & Early Development,DTA Cardiovascular & Metabolism, F. Hoffmann-La Roche Ltd, Basel, Switzerland; 3 Genentech, South San Francisco, CA *CR <strong>Wednesday</strong> Posters 11:00 am – 12:45 pm f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 299
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