Wednesday - ARVO

4509 – 4524 – Wednesday – Papers/Minisymposium
Wednesday Papers/
Minisymposium
11:00 am – 12:45 pm
4509 — 12:15 Long-Term and Lasting
Outcomes of Combination Treatment for
Age-Related Macular Degeneration with
Photodynamic Therapy and Intravitreal
Injection of Anti-Vascular Endothelial Growth
Factor. Colleen M. McLellan, R. Silva-Garcia, K.
W. Small. Molecular Insight Research Foundation,
Glendale, CA *CR
6E
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Retina
426 Macular Disease Other
Than AMD II
Moderators: William F. Mieler and
K. Bailey Freund
4510 — 11:00 Occult Central Serous
Chorioretinopathy. K Bailey Freund 1, 2 , D.
Warrow 3 , R. Gallego-Pinazo 1, 5 , Q. V. Hoang 4 .
1
Ophthalmology, Vitreous Retina Macula
Consultants New York, New York, NY;
2
Ophthalmology, New York University, New
York, NY; 3 Ophthamology, New York Eye and
Ear Infirmary, New York, NY; 4 Ophthalmology,
Columbia University, New York, NY;
5
Ophthalmology, University and Polytechnic
Hospital La Fe, Valencia, Spain *CR
4511 — 11:15 Effect of Somatostatin on the
expression of tight junctions and urokinase
plasminogen activator receptor in human retinal
pigment epithelial cells. Alex Fonollosa 1, 2 , J.
Artaraz 1 , A. Martinez-Berriotxoa 1 , E. Vecino 2 .
1
Ophthalmology, Hospital de Cruces, Portugalete,
Spain; 2 Grupo de Oftalmobiologia Experimental,
Bilbao, Spain
4512 — 11:30 Selective Laser Photocoagulation
of Peripheral Non-perfused Retinal Areas
May Improve the Vision in Patients with
Central Retinal Vein Occlusion Treated with
Ranibizumab. Matus Rehak 1 , A. Franke 2 , P. M.
Wiedemann 1 . 1 Department of Ophthalmology,
University of Leipzig, Leipzig, Germany; 2 Clinical
Trial Centre (ZKS) Leipzig, University of Leipzig,
Leipzig, Germany *CR, f
4513 — 11:45 Macular Bruchs Membrane
Defects and Axial Length: Association with
Gamma Zone and Delta Zone in Peripapillary
Region. Jost B. Jonas 1 , K. Ohno-Matsui 2 ,
R. F. Spaide 3 , L. Holbach 4 , S. Panda-Jonas 1 .
1
Ophthalmology, Medical Faculty Mannheim-
Heidelberg, Mannheim, Germany; 2 Department
of Ophthalmology and Visual Science, Tokyo
Medical and Dental University, Tokyo, Japan;
3
Vitreous-Retina-Macula Consultants of New
York and the LuEsther T. Mertz Retinal Research
Center, Manhattan Eye, Ear, and Throat Hospital,
New York, NY; 4 Department of Ophthalmology,
Friedrich-Alexander University Erlangen-Nürnberg,
Erlangen, Germany *CR
4514 — 12:00 Treatment Experience with
Intravitreal Aflibercept Injection (IAI) After
Switching to PRN Dosing in Patients with
Macular Edema Secondary to Central Retinal
Vein Occlusion (CRVO). David M. Brown 1 , F. G.
Holz 2 . 1 Retina Consultants of Houston, Houston,
TX; 2 Department of Ophthalmology, University of
Bonn, Bonn, Germany *CR, f
4515 — 12:15 Two-Year Results of the
COPERNICUS Study Evaluating Intravitreal
Aflibercept Injection (IAI) for Macular Edema
Secondary to Central Retinal Vein Occlusion
(CRVO). W. Lloyd Clark. Palmetto Retina Center,
West Columbia, SC *CR, f
4516 — 12:30 Eighteen-Month Results of
the GALILEO Study Evaluating Intravitreal
Aflibercept Injection (IAI) for Macular Edema
Secondary to Central Retinal Vein Occlusion
(CRVO). Yuichiro Ogura 1 , J. Korobelnik 2 , J.
Roider 3 , R. Vitti 4 , F. G. Holz 5 , F. Hiemeyer 6 , B.
Stemper 6 , O. Zeitz 6 , R. Sandbrink 6 . 1 Department
of Ophthalmology, Nagoya City University
Medical School, Nagoya, Japan; 2 Department
of Ophthalmology, CHU Bordeaux, Universite
Bordeuax, Bordeaux, France; 3 Department of
Ophthalmology, University Medical Center
Schleswig-Holstein, Kiel, Germany; 4 Regeneron
Pharmaceuticals Inc., Tarrytown, NY; 5 Department
of Ophthalmology, University of Bonn, Bonn,
Germany; 6 Bayer Healthcare, Berlin, Germany
*CR, f
606/607
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Immunology/Microbiology
427 Ocular Immune Responses
Moderators: Holly L. Rosenzweig and
Thomas Langmann
4517 — 11:00 Loss of MicroRNA-124
and MicroRNA-126 expression regulates
inflammatory microglial activation in inherited
retinal degeneration. Thomas Langmann 1, 2 , C.
Moehle 3 , M. Karlstetter 1 , B. H. Weber 2 . 1 Department
of Ophthalmology, University of Cologne, Cologne,
Germany; 2 Institute of Human Genetics, University
of Regensburg, Regensburg, Germany; 3 Center of
Excellence for Fluorescent Bioanalytics, University
of Regensburg, Regensburg, Germany
4518 — 11:15 Mice lacking TNFR1 develop
less angiogenesis during late stage experimental
autoimmune uveoretinitis (EAU). Madeleine
Stimpson 1 , J. Liu 1 , D. A. Copland 1 , T. K. Khera 1 ,
A. D. Dick 1, 2 . 1 Academic Unit of Ophthalmology,
University of Bristol, Bristol, United Kingdom;
2
Cellular and Molecular Medicine, University of
Bristol, Bristol, United Kingdom *CR
4519 — 11:30 Differential effects of TLR-
3 activated RPE on retinal microglia and
blood-derived monocytes. Alexa K. Klettner 1 ,
T. Hamann 1 , S. Wilker 1 , C. Berg 1 , K. Schlüter 1 , R.
Lucius 2 , M. Rolf 2 , J. Roider 1 . 1 Ophthalmology, Univ
of Kiel, Kiel, Univ Medical Center, Kiel, Germany;
2
Anatomy, University of Kiel, Kiel, Germany *CR
4520 — 11:45 Demonstration of Donor T cell
Recruitment and Correlation with Inflammatory
Cytokine Presence in Experimental Ocular
Graft-versus-Host Disease. Samantha Herretes 1 ,
J. C. Murillo 1 , D. Ross 2 , H. Barreras 2 , Y. Tan 1 , A. M.
Saeed 1 , A. Gonzalez 1 , C. Betancurt 1 , R. B. Levy 2 , V.
L. Perez 1, 2 . 1 Ophthalmology, Bascom Palmer Eye
Inst, Univ of Miami, Miami, FL; 2 Immunology and
Microbiology, University of Miami, Miami, FL *CR
4521 — 12:00 Monophasic PDSAg-induced
EAU dominates over relapsing R14-induced
EAU. Ulrike Kaufmann, M. Diedrichs-Möhring,
G. Wildner. Ophthalmology, Clinic of the Ludwig-
Maximilians-University, Munich, Germany
4522 — 12:15 Inhibition of Vascular
Endothelial Growth Factor Ameliorates Ocular
Allergy in the Murine Model. Daniel R. Saban 1 ,
R. Dana 2 , H. Lee 2 , T. Blanco 1 . 1 Ophthalmology,
Duke University School of Medicine, Durham, NC;
2
Ophthalmology, Schepens Eye Res Inst, Mass. Eye
& Ear, Harvard Medical School, Boston, MA *CR
4523 — 12:30 Translational Modeling of
Calpain-5 Vitreoretinopathy Mechanisms
in Mice. Vinit B. Mahajan 1, 2 , K. J. Wert 3 , J. M.
Skeie 1, 2 , S. H. Tsang 4 . 1 Ophthalmology, University
of Iowa, Iowa City, IA; 2 Omics Laboratory,
University of Iowa, Iowa City, IA; 3 Institute of
Human Nutrition, Columbia University, New York,
NY; 4 Ophthalmology, Columbia University, New
York, NY
608
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Anatomy/Pathology
428 Uveal Melanoma: Experimental
Therapeutics
Moderators: Hans Grossniklaus, Sarah E.
Coupland and Arun D. Singh
4524 — 11:00 Microphthalmia-associated
transcription factor (MITF) and Steroid
Receptor Coactivator (SRC)-3 cooperate to
promote proliferation, survival and metabolism
in Gα-mutant uveal melanoma (UM) cells.
Vassiliki Poulaki 1, 2 , S. Chew 3, 4 , B. He 3, 4 , V.
Eedunuri 5 , M. M. Jager 6 , B. W. O’Malley 4 ,
N. Mitsiades 3, 4 . 1 Ophthalmology, Boston VA
Healthcare System, Boston, MA; 2 Ophthalmology,
Boston University, Boston, MA; 3 Medicine,
Baylor College of Medicine, Houston, TX;
4
Molecular and Cellular Biology, Baylor College
of Medicine, Houston, TX; 5 Adrienne Helis Malvin
Medical Research Foundation, New Orleans, LA;
6
Ophthalmology, Leiden University Medical Center,
Leiden, Netherlands
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
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