Wednesday - ARVO

Wednesday – Papers/Minisymposium – 4497 – 4508
6B
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Glaucoma
424 Genetics I
Moderators: John H. Fingert and
Andrew J. Lotery
4497 — 11:00 Genome-wide Association Study
and Meta-Analysis of Intraocular Pressure in
Primary Open-Angle Glaucoma Cases and
Controls in the NEIGHBOR, GLAUGEN and
AMD-MMAP Studies. Sayoko E. Moroi 1 , A. B.
Ozel 2 , D. M. Reed 1 , K. E. Branham 1 , M. A. Hauser 3 ,
L. R. Pasquale 4 , J. L. Wiggs 4 , J. E. Richards 1 , J. Z.
Li 2 . 1 Ophthalmology & Visual Sciences, Univ of
Michigan-Kellogg Eye Ctr, Ann Arbor, MI; 2 Human
Genetics, University of Michigan, Ann Arbor, MI;
3
Center for Human Genetics, Duke University
School of Medicine, Durham, NC; 4 Department
of Ophthalmology, Harvard Medical School,
Massachusetts Eye and Ear Infirmary, Boston, MA
*CR
4498 — 11:15 Molecular mechanisms in
Primary Glaucoma: POAG-associated variant
disrupts microRNA regulation of CDKN2B
expression. Terry Gaasterland 1, 2 , A. N. Dubinsky 3 ,
A. R. La Spada 3, 8 , K. Mansouri 4, 10 , K. H. Willert 8, 9 ,
D. E. Gaasterland 5 , M. A. Hauser 6 , L. R. Pasquale 7 ,
J. L. Wiggs 7 , R. N. Weinreb 10 . 1 Institute for Genomic
Medicine, Univ of California San Diego, La Jolla,
CA; 2 Marine Biology Research Division, Univ of
California San Diego, La Jolla, CA; 3 Department of
Pediatrics, Univ of California San Diego, La Jolla,
CA; 4 University of Geneva, Geneva, Switzerland;
5
Ophthalmology, Potomac, MD; 6 Department
of Medicine, Duke University, Durham, NC;
7
Massachusetts Eye and Ear Institute, Harvard,
Cambridge, MA; 8 Cellular and Molecular Medicine;
Neurosciences, Univ of California San Diego, La
Jolla, CA; 9 Sanford Consortium for Regenerative
Medicine, La Jolla, CA; 10 Hamilton Glaucoma
Center, Univ of California San Diego, La Jolla, CA
*CR
4499 — 11:30 Runs of Homozygosity Across
the Whole Genome Suggests two Novel Genes
in Primary Congenital Glaucoma. Subhabrata
Chakrabarti 1 , S. Ganguly 3 , M. Kabra 1 , A. K.
Mandal 2 , S. Senthil 1 , I. Kaur 1 , P. P. Majumder 4, 3 .
1
Brien Holden Eye Research Centre, LV Prasad Eye
Institute, Hyderabad, India; 2 Jasti V Ramanamma
Childrens Eye Care Centre, L V Prasad Eye
Institute, Hyderabad, India; 3 Department of Human
Genetics, Indian Statistical Institute, Kolkata,
India; 4 National Institute of Biomedical Genomics,
Kalyani, India
4500 — 11:45 Genetic factors and pathways
affecting retinal nerve fiber layer thickness.
Cristina Venturini 1, 2 , P. G. Hysi 2 , A. Nag 2 , E.
Yonova 2 , J. Wang 3, 4 , T. Y. Wong 5, 6 , P. R. Healey 4 ,
P. Mitchell 4 , C. J. Hammond 2 , A. C. Viswanathan 7,
8
. 1 Genetics, UCL, Institute of Ophthalmology,
London, United Kingdom; 2 Twin Research &
Epidemiology Research, King’s College London,
London, United Kingdom; 3 Centre for Eye Research
Australia (CERA), Department of Ophthalmology,
University of Melbourne, Melbourne, NSW,
Australia; 4 Department of Ophthalmology,
University of Sydney Centre for Vision Research,
Sydney, NSW, Australia; 5 Epidemiology and
Public Health, National University of Singapore,
Singapore, Singapore; 6 Singapore Eye Research
Institute, Singapore, Singapore; 7 Glaucoma Service,
Moorfield Eye Hospital, London, United Kingdom;
8
NIHR Biomedical Research Centre, Moorfield
Eye Hospital and UCL Institute of Ophthalmology,
London, United Kingdom *CR
4501 — 12:00 The role of SIX6 in primary
open-angle glaucoma. Michael A. Hauser 1, 2 , M.
Ulmer 1 , Y. Liu 3 , E. Davis 3 , N. Katsanis 3 , Y. Liu 1 ,
L. R. Pasquale 4 , J. L. Wiggs 4 , A. E. Ashley-Koch 1 ,
R. Allingham 2 . 1 Medicine, Duke Univ Medical
Center, Durham, NC; 2 Ophthalmology, Duke Univ
Medical Center, Durham, NC; 3 Cell Biology, Duke
University, Durham, NC; 4 Ophthalmology, Harvard
Medical School, Boston, MA *CR
4502 — 12:15 A genome-wide association
study of intra-ocular pressure identifies a
novel association in the gene FAM125B in the
TwinsUK cohort. Abhishek Nag 1 , P. G. Hysi 1 ,
C. Venturini 2, 1 , E. Yonova 1 , K. M. Williams 1 , C.
J. Hammond 1 . 1 Department of Twin Research,
King’s College London, London, United Kingdom;
2
Institute of ophthalmology, University College
London, London, United Kingdom
4503 — 12:30 Identification of further novel
genome wide significant loci for open angle
glaucoma blindness utilizing the Australian
and New Zealand Registry of Advanced
Glaucoma. Jamie E. Craig 1 , A. W. Hewitt 2, 1 ,
S. Graham 3 , P. R. Healey 4 , R. J. Casson 5 , P.
Mitchell 4 , J. Landers 1 , S. MacGregor 6 , D. A.
Mackey 2 , K. P. Burdon 1 . 1 Ophthalmology, Flinders
University, Bedford Park, Adelaide, SA, Australia;
2
Ophthalmology, Lions Eye Institute, Perth, WA,
Australia; 3 Ophthalmology, Macquarie University,
Sydney, NSW, Australia; 4 Ophthalmology,
Sydney University, Sydney, NSW, Australia;
5
Ophthalmology, Adelaide University, Adelaide,
SA, Australia; 6 Queensland Institute of Medical
Research, Brisbane, QLD, Australia *CR
6C
Wednesday, May 08, 2013 11:00 AM-12:45 PM
Retina
425 AMD: Novel and
Combination Therapies
Moderators: Susanne Binder and Pravin U. Dugel
4504 — 11:00 Anti-VEGF Gene Therapy for
Wet AMD: Safety and Tolerability of Subretinal
Delivery in a Phase I/II Clinical Trial. Ian
Constable 1, 2 , C. Pierce 2 , S. K. Somasundaram 2 ,
M. Lai 1, 2 , T. W. Chalberg 3 , M. S. Blumenkranz 4 ,
R. Samulski 5 , E. P. Rakoczy 1, 2 . 1 Centre for
Ophthalmology and Visual Sciences, University
of Western Australia, Perth, WA, Australia; 2 Lions
Eye Institute, Perth, WA, Australia; 3 Avalanche
Biotechnologies, San Francisco, CA; 4 Byers Eye
Institute at Stanford, Palo Alto, CA; 5 Pharmacology
and Gene Therapy Center, University of North
Carolina, Chapel Hill, NC *CR, f
4505 — 11:15 Phase I, Masked, Placebo-
Controlled, Single and Multiple Ascending
Intravenous Dose Studies Evaluating Systemic
and Ocular Safety, Tolerability, and Visual
Acuity Effects of RN6G (PF-04382923) in
Subjects with Dry, Age-Related Macular
Degeneration (ARMD). Brian B. Berger 1 , P.
D. Garzone 2 , I. Gunderson 1 , P. M. Fanning 2 , G.
Wong 2 , K. H. Liao 2 , S. Y. Hua 2 , J. Lin 2 . 1 Retina
Research Center, Austin, TX; 2 Pfizer Inc., South San
Francisco, CA *CR, f
4506 — 11:30 A Phase 2 Double-masked,
Placebo-controlled, Dose Ranging Study of
Emixustat Hydrochloride (ACU-4429) in
Subjects with GA Associated with Dry AMD.
Pravin U. Dugel 1 , R. L. Novack 2 , K. G. Csaky 3 , P.
P. Richmond 4 , D. G. Birch 5 , R. Kubota 6 . 1 Retinal
Consultants of Arizona, Ltd, Phoenix, AZ; 2 Retina-
Vitreous Associates Medical Group, Beverly Hills,
CA, Beverly Hills, CA; 3 Texas Retina Associates,
Dallas, TX, Dallas, TX; 4 Central Florida Retina,
Orlando, FL, Orlando, FL; 5 Retina Foundation of
Southwest, Dallas, TX, Dallas, TX; 6 Acucela Inc.,
Seattle, WA, Seattle, WA *CR, f
4507 — 11:45 Photodynamic Therapy vs
Combination Therapy in Polypoidal Choroidal
Vasculopathy: Changes of Aqueous Vascular
Endothelial Growth Factor. Meeyon Lee 1 , W. Lee 2 .
1
Chung ang University hospital, Seoul, Republic of
Korea; 2 Seoul St. Mary hospital, Seoul, Republic of
Korea *CR, f
4508 — 12:00 Twelve Months Results
Comparing Ranibizumab or Bevacizumab
Treatment in Patients with Neovascular Agerelated
Macular Degeneration(AMD) Multicenter
Anti-VEGF Trial in Austria The Manta Study.
Susanne Binder 1 , I. Krebs 1 , L. Schmetterer 2 .
1
Ophthalmology, Rudolf Foundation Clinic, Vienna,
Austria; 2 Department of Clinical Pharmacology,
Medical University, Vienna, Austria f
Wednesday Papers/
Minisymposium
11:00 am – 12:45 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
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