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4475 – 4496 – Wednesday – Posters Wednesday Posters 8:30 am – 10:15 am 4475 — D0215 Evaluation of surface free energy of Aurolab Aqueous Drainage Implant (AADI) and its influence on cell adhesion property, in comparison with Baerveldt Implant. Chidambaranathan Gowri Priya 1 , K. Sivakumar 2 , M. Pillai 3 , S. Krishnadas 4 , R. D. Sriram 5 , V. Muthukkaruppan 6 . 1 Department of Immunology and Stem Cell Biology, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Madurai, India; 2 Polymer Division, Aurolab, Madurai, India; 3 Glaucoma Clinic, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, India; 4 Glaucoma Clinic, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, India; 5 Aurolab, Madurai, India; 6 Department of Immunology and Stem Cell Biology, Aravind Medical Research Foundation, Dr. G. Venkataswamy Eye Research Institute, Madurai, India *CR 4476 — D0216 Targeting specific TGF-β signaling pathways to prevent bleb fibrosis after glaucoma drainage device surgery. Christian K. Vorwerk 1 , V. Sokalskis 2 , A. Zabelyshenskiy 2 , H. Thieme 1 , L. Choritz 1, 2 . 1 Dept of Ophthalmology, Otto von Guericke University, Magdeburg, Germany; 2 Dept of Ophthalmology, University Medical Center, Mainz, Germany 4477 — D0217 Retrospective study of congenital glaucoma surgical treatment. Hector Bello Lopez Portillo, J. Jimenez-Roman, M. Turati- Acosta, M. García-Huerta, R. Castañeda Diez, F. Gil Carrasco, C. Isida Llerandi. Asociacion para Evitar la Ceguera en Mexico, Mexico, Mexico 4478 — D0218 Intraocular Pressure Reduction of Modified 360-degree Suture Trabeculotomy in Intent-to-treat Eyes. Daisuke Shiba, T. Ono, N. Ozeki, K. Yuki, K. Tsubota. Ophthalmology, Keio University, Shinjuku-ku, Japan *CR 4479 — D0219 Evaluation of Dose Effect of ALK-5 Inhibitor and Controlled Delivery with Novel Pentablock Polymer in Glaucoma Filtration Surgery. Hiroshi Nakamura 1, 2 , J. J. Dunmire 1 , V. Sutariya 2, 3 , M. Hewit 2 , D. Wehrung 2 , S. Patel 4 , A. K. Mitra 4 . 1 Ophthalmology, Summa Health System, Akron, OH; 2 Pharmaceutical sciences, Northeast Ohio Medical University, Rootstown, OH; 3 Pharmaceutical sciences, University of South Florida, Tampa, FL; 4 Pharmaceutical sciences, University of Missouri- Kansas City, Kansas City, MO 4480 — D0220 The effect of steroid and matrix metalloproteinase inhibitor on bleb survival in an experimental animal model. Alastair Lockwood 1, 2 , A. Mohamed Ahmed 1, 2 , A. Khalili 1, 2 , S. Awwad 1, 2 , G. Sharma 1, 2 , S. Brocchini 1, 2 , P. T. Khaw 1 . 1 NIHR Moorfields Biomedical Research Centre, London, United Kingdom; 2 UCL School of Pharmacy, University College London, London, United Kingdom *CR 4481 — D0221 Attenuation of Glaucoma Filtration Surgery-induced Scarring by an FDA-approved Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid (SAHA). Ajay Sharma, J. W. Brubaker, M. Reyes, J. T. Rodier, A. Tandon, R. R. Mohan. Mason Eye Institute, University of Missouri, Columbia, MO 4482 — D0222 Surgical Outcomes of Augmented MMC Trabeculectomy After Failed Seton Surgery. Jose A. Paczka 1, 3 , L. A. Giorgi-Sandoval 2, 3 , M. A. Ramos-Hernandez 1 , J. Jimenez-Roman 2, 3 , A. Merikansky 2 . 1 Oftalmologia, University of Guadalajara, Guadalajara, Mexico; 2 Oftalmologia, Asistencia e Investigacion en Glaucoma, A.C., Guadalajara, Mexico; 3 Glaucoma, Global Glaucoma Institute, Guadalajara, Mexico 4483 — D0223 Influence of endothelin-1 in aqueous humor on IOP and filtration surgery outcome. Lars Choritz 1, 2 , B. Mahmoodi 1 , M. Machert 1 , N. Pfeiffer 1 , H. Thieme 2 . 1 Ophthalmology, University Medical Center, Mainz, Germany; 2 Ophthalmology, University Clinic, Otto von Guericke University, Magdeburg, Germany *CR 4484 — D0224 A New Technique for Glaucoma Surgery: Scorolli Trabeculectomy. Lucia Scorolli 1 , E. Meduri 2 , A. De Leo 5 , R. Meduri 3 , E. Zere 4 , P. Piccaluga 5 , S. Scalinci 1 . 1 Ophthalmology, S Orsola Malpighi Hospital Bologna, Bologna, Italy; 2 Medical School, University of Sophia, Sophia, Bulgaria; 3 IE Business School, Madrid, Spain; 4 Ophthalmology, Univesity La Sapienza, Rome, Italy; 5 Molecular Pahology, University of Bologna, Bologna, Italy 4485 — D0225 Functional and anatomic outcomes following endocyclophotocoagulation (ECP) surgery for neo-vascular glaucoma as compared to routine glaucoma care. Kyle V. Marra 1 , S. Wagley 2 , A. F. Omar 3 , J. G. Arroyo 1 . 1 Beth Israel Deaconess Medical Center, Boston, MA; 2 College of Human Medicine - Michigan State University, East Lansing, MI; 3 Joslin Diabetes Center, Boston, MA 4486 — D0226 Efficacy of Catheter Assisted 360° Trabeculotomy in Primary Congenital Glaucoma (PCG). Erika Wandel 1 , D. Dave 1 , M. Vora 2 , C. H. Marcus 3 , R. F. Rothman 3 , T. Frempong 1 , D. D. Hayes 3 , A. Angelilli 3 , J. B. Serle 1, 3 . 1 Ophthalmology, Mount Sinai Hospital, New York, NY; 2 Ophthalmology, North Shore-Long Island Jewish Health System, Manhasset, NY; 3 Glaucoma Consultants of Long Island, Bethpage, NY *CR 4487 — D0227 Ahmed glaucoma valve FP7 and FP8 in pediatric glaucoma: A randomized clinical trial. Bruno L. Esporcatte, C. F. Netto, T. Tanno, L. S. Melo, I. M. Tavares, C. Rolim de Moura. Glaucoma, Federal University of São Paulo, São Paulo, Brazil f 4488 — D0228 A model to measure surgical outflow using a two-tubed experimental glaucoma drainage device. Craig Ross, D. Nguyen, S. S. Pandav, Y. Li, J. G. Crowston, M. A. Coote. Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia 4489 — D0229 Comparison of Early Post- Operative Challenges in P200 Ex-PRESS Shunts and Conventional Trabeculectomies. Maheen Haque, B. A. Hughes, J. Tannir, R. Momi, C. Kim. Kresge Eye Institute/Wayne State University, Detroit, MI 4490 — D0230 Comparision of surgical outcomes of Express Shunt and Ahmed Valve in Neovascular Glaucoma. Huseyin Kadikoy, B. A. Hughes, J. Tannir, R. Momi. Ophthalmology, Kresge Eye Institute, Royal Oak, MI 4491 — D0231 A Novel Minimally Invasive Drainage Implant (the MIDI-Arrow): One-Two Year Follow Up. Paul F. Palmberg 1 , J. F. Batlle 3 , R. Alburquerque 3 , A. Corona-Peralta 3 , I. Riss 4 , R. Parrish 1 , E. Arrieta 2 , J. A. Parel 2 . 1 Biophysics (Ophthalmology), University of Miami, Miami, FL; 2 Ophthalmology, University of Miami, Miami, FL; 3 Centro Laser, Santo Domingo, Dominican Republic; 4 Pole Ophtalmologogique, Clinique Mutualiste, Pessac, France *CR, f 4492 — D0232 Surgical Outcomes in First 25 Canaloplasties and Impact of Growing Experience on Complications. Elisabeth P. Aponte, J. Eisengart. Ophthalmology, Cleveland Clinic Cole Eye Institute, Cleveland, OH 4493 — D0233 Review of the Success Rate of an Intraoperative Modified Bleb Revision Technique. Priya Gupta, K. S. Arora, C. Lee, D. S. Friedman. Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD *CR 4494 — D0234 Clinical and Tomographic Findings in Filtering Blebs Undergoing Digital Compression. Miriam A. Ramos-Hernandez 2 , M. A. Ramos-Hernandez 2 , E. Chavez 2 , L. A. Giorgi-Sandoval 1 , J. A. Paczka 1, 2 . 1 Asistencia e Investigacion en Glaucoma, A.C., Guadalajara, Mexico; 2 Instituto de Oftalmologia y Ciencias Visuales, Guadalajara, Mexico 4495 — D0235 Cyclodialysis incidence in anterior segment surgery in an Ophthalmology Referral Center. Rodrigo Bolanos 1 , A. Navas 3 , E. O. Graue-Hernández 3 , A. J. Ramirez-Miranda 3 , J. Ledesma Gil 2 . 1 Research Unit, Inst of Ophthal Conde de Valenciana, Mexico City, Mexico; 2 Glaucoma, Instituto de Oftalmologia Conde de Valenciana, Mexico DF, Mexico; 3 Cornea An Refractive Surgery, Instituto de Oftalmologia Conde de Valenciana, Mexico DF, Mexico *CR 4496 — D0236 Optimal administration route of bevacizumab after glaucoma filtration surgery. Karolien P. Hollanders 1 , T. Van Bergen 1 , D. Sijnave 1 , S. Van de Velde 1 , E. Vandewalle 1 , L. K. Moons 2 , I. Stalmans 1 . 1 Neuroscience, Lab of Ophthalmology, KULeuven, Leuven, Belgium; 2 Biology, KULeuven, Leuven, Belgium *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 292
Wednesday – Papers/Minisymposium – 4497 – 4508 6B Wednesday, May 08, 2013 11:00 AM-12:45 PM Glaucoma 424 Genetics I Moderators: John H. Fingert and Andrew J. Lotery 4497 — 11:00 Genome-wide Association Study and Meta-Analysis of Intraocular Pressure in Primary Open-Angle Glaucoma Cases and Controls in the NEIGHBOR, GLAUGEN and AMD-MMAP Studies. Sayoko E. Moroi 1 , A. B. Ozel 2 , D. M. Reed 1 , K. E. Branham 1 , M. A. Hauser 3 , L. R. Pasquale 4 , J. L. Wiggs 4 , J. E. Richards 1 , J. Z. Li 2 . 1 Ophthalmology & Visual Sciences, Univ of Michigan-Kellogg Eye Ctr, Ann Arbor, MI; 2 Human Genetics, University of Michigan, Ann Arbor, MI; 3 Center for Human Genetics, Duke University School of Medicine, Durham, NC; 4 Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA *CR 4498 — 11:15 Molecular mechanisms in Primary Glaucoma: POAG-associated variant disrupts microRNA regulation of CDKN2B expression. Terry Gaasterland 1, 2 , A. N. Dubinsky 3 , A. R. La Spada 3, 8 , K. Mansouri 4, 10 , K. H. Willert 8, 9 , D. E. Gaasterland 5 , M. A. Hauser 6 , L. R. Pasquale 7 , J. L. Wiggs 7 , R. N. Weinreb 10 . 1 Institute for Genomic Medicine, Univ of California San Diego, La Jolla, CA; 2 Marine Biology Research Division, Univ of California San Diego, La Jolla, CA; 3 Department of Pediatrics, Univ of California San Diego, La Jolla, CA; 4 University of Geneva, Geneva, Switzerland; 5 Ophthalmology, Potomac, MD; 6 Department of Medicine, Duke University, Durham, NC; 7 Massachusetts Eye and Ear Institute, Harvard, Cambridge, MA; 8 Cellular and Molecular Medicine; Neurosciences, Univ of California San Diego, La Jolla, CA; 9 Sanford Consortium for Regenerative Medicine, La Jolla, CA; 10 Hamilton Glaucoma Center, Univ of California San Diego, La Jolla, CA *CR 4499 — 11:30 Runs of Homozygosity Across the Whole Genome Suggests two Novel Genes in Primary Congenital Glaucoma. Subhabrata Chakrabarti 1 , S. Ganguly 3 , M. Kabra 1 , A. K. Mandal 2 , S. Senthil 1 , I. Kaur 1 , P. P. Majumder 4, 3 . 1 Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India; 2 Jasti V Ramanamma Childrens Eye Care Centre, L V Prasad Eye Institute, Hyderabad, India; 3 Department of Human Genetics, Indian Statistical Institute, Kolkata, India; 4 National Institute of Biomedical Genomics, Kalyani, India 4500 — 11:45 Genetic factors and pathways affecting retinal nerve fiber layer thickness. Cristina Venturini 1, 2 , P. G. Hysi 2 , A. Nag 2 , E. Yonova 2 , J. Wang 3, 4 , T. Y. Wong 5, 6 , P. R. Healey 4 , P. Mitchell 4 , C. J. Hammond 2 , A. C. Viswanathan 7, 8 . 1 Genetics, UCL, Institute of Ophthalmology, London, United Kingdom; 2 Twin Research & Epidemiology Research, King’s College London, London, United Kingdom; 3 Centre for Eye Research Australia (CERA), Department of Ophthalmology, University of Melbourne, Melbourne, NSW, Australia; 4 Department of Ophthalmology, University of Sydney Centre for Vision Research, Sydney, NSW, Australia; 5 Epidemiology and Public Health, National University of Singapore, Singapore, Singapore; 6 Singapore Eye Research Institute, Singapore, Singapore; 7 Glaucoma Service, Moorfield Eye Hospital, London, United Kingdom; 8 NIHR Biomedical Research Centre, Moorfield Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom *CR 4501 — 12:00 The role of SIX6 in primary open-angle glaucoma. Michael A. Hauser 1, 2 , M. Ulmer 1 , Y. Liu 3 , E. Davis 3 , N. Katsanis 3 , Y. Liu 1 , L. R. Pasquale 4 , J. L. Wiggs 4 , A. E. Ashley-Koch 1 , R. Allingham 2 . 1 Medicine, Duke Univ Medical Center, Durham, NC; 2 Ophthalmology, Duke Univ Medical Center, Durham, NC; 3 Cell Biology, Duke University, Durham, NC; 4 Ophthalmology, Harvard Medical School, Boston, MA *CR 4502 — 12:15 A genome-wide association study of intra-ocular pressure identifies a novel association in the gene FAM125B in the TwinsUK cohort. Abhishek Nag 1 , P. G. Hysi 1 , C. Venturini 2, 1 , E. Yonova 1 , K. M. Williams 1 , C. J. Hammond 1 . 1 Department of Twin Research, King’s College London, London, United Kingdom; 2 Institute of ophthalmology, University College London, London, United Kingdom 4503 — 12:30 Identification of further novel genome wide significant loci for open angle glaucoma blindness utilizing the Australian and New Zealand Registry of Advanced Glaucoma. Jamie E. Craig 1 , A. W. Hewitt 2, 1 , S. Graham 3 , P. R. Healey 4 , R. J. Casson 5 , P. Mitchell 4 , J. Landers 1 , S. MacGregor 6 , D. A. Mackey 2 , K. P. Burdon 1 . 1 Ophthalmology, Flinders University, Bedford Park, Adelaide, SA, Australia; 2 Ophthalmology, Lions Eye Institute, Perth, WA, Australia; 3 Ophthalmology, Macquarie University, Sydney, NSW, Australia; 4 Ophthalmology, Sydney University, Sydney, NSW, Australia; 5 Ophthalmology, Adelaide University, Adelaide, SA, Australia; 6 Queensland Institute of Medical Research, Brisbane, QLD, Australia *CR 6C Wednesday, May 08, 2013 11:00 AM-12:45 PM Retina 425 AMD: Novel and Combination Therapies Moderators: Susanne Binder and Pravin U. Dugel 4504 — 11:00 Anti-VEGF Gene Therapy for Wet AMD: Safety and Tolerability of Subretinal Delivery in a Phase I/II Clinical Trial. Ian Constable 1, 2 , C. Pierce 2 , S. K. Somasundaram 2 , M. Lai 1, 2 , T. W. Chalberg 3 , M. S. Blumenkranz 4 , R. Samulski 5 , E. P. Rakoczy 1, 2 . 1 Centre for Ophthalmology and Visual Sciences, University of Western Australia, Perth, WA, Australia; 2 Lions Eye Institute, Perth, WA, Australia; 3 Avalanche Biotechnologies, San Francisco, CA; 4 Byers Eye Institute at Stanford, Palo Alto, CA; 5 Pharmacology and Gene Therapy Center, University of North Carolina, Chapel Hill, NC *CR, f 4505 — 11:15 Phase I, Masked, Placebo- Controlled, Single and Multiple Ascending Intravenous Dose Studies Evaluating Systemic and Ocular Safety, Tolerability, and Visual Acuity Effects of RN6G (PF-04382923) in Subjects with Dry, Age-Related Macular Degeneration (ARMD). Brian B. Berger 1 , P. D. Garzone 2 , I. Gunderson 1 , P. M. Fanning 2 , G. Wong 2 , K. H. Liao 2 , S. Y. Hua 2 , J. Lin 2 . 1 Retina Research Center, Austin, TX; 2 Pfizer Inc., South San Francisco, CA *CR, f 4506 — 11:30 A Phase 2 Double-masked, Placebo-controlled, Dose Ranging Study of Emixustat Hydrochloride (ACU-4429) in Subjects with GA Associated with Dry AMD. Pravin U. Dugel 1 , R. L. Novack 2 , K. G. Csaky 3 , P. P. Richmond 4 , D. G. Birch 5 , R. Kubota 6 . 1 Retinal Consultants of Arizona, Ltd, Phoenix, AZ; 2 Retina- Vitreous Associates Medical Group, Beverly Hills, CA, Beverly Hills, CA; 3 Texas Retina Associates, Dallas, TX, Dallas, TX; 4 Central Florida Retina, Orlando, FL, Orlando, FL; 5 Retina Foundation of Southwest, Dallas, TX, Dallas, TX; 6 Acucela Inc., Seattle, WA, Seattle, WA *CR, f 4507 — 11:45 Photodynamic Therapy vs Combination Therapy in Polypoidal Choroidal Vasculopathy: Changes of Aqueous Vascular Endothelial Growth Factor. Meeyon Lee 1 , W. Lee 2 . 1 Chung ang University hospital, Seoul, Republic of Korea; 2 Seoul St. Mary hospital, Seoul, Republic of Korea *CR, f 4508 — 12:00 Twelve Months Results Comparing Ranibizumab or Bevacizumab Treatment in Patients with Neovascular Agerelated Macular Degeneration(AMD) Multicenter Anti-VEGF Trial in Austria The Manta Study. Susanne Binder 1 , I. Krebs 1 , L. Schmetterer 2 . 1 Ophthalmology, Rudolf Foundation Clinic, Vienna, Austria; 2 Department of Clinical Pharmacology, Medical University, Vienna, Austria f Wednesday Papers/ Minisymposium 11:00 am – 12:45 pm f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 293
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Wednesday - ARVO

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