Wednesday - ARVO

4302 – 4321 – Wednesday – Posters
Wednesday Posters
8:30 am – 10:15 am
4302 — C0040 Delayed corneal wound
healing resulting from the administration
of fluoroquinolone antibacterial ophthalmic
solutions and its causes. Masamichi Fukuda, Y.
Seki, Y. Kurihara, S. Enta, N. Shibata, K. Hagiwara,
H. Osada, S. Shibata, E. Kubo, H. Sasaki.
Ophthalmology, Kanazawa Medical University,
Uchinada, Japan
4303 — C0041 Penetration of Eye Drop
Solutions of Fluoroquinolones into the Cornea
and Anterior Chamber of Human Enucleated
Eyes. Sidney J. Sousa, G. C. Mendonça.
Ophthalmology, Univ of Sao Paulo-Sch of Med,
Ribeirao Preto, Brazil
4304 — C0042 To evaluate the efficacy of
corneal collagen crosslinking in fungal corneal
ulcers. Shah Nawaz, P. K. Maharana, N. Sharma,
R. B. Vajpayee. Opthalmology, R.P.Centre, AIIMS,
New Delhi, India
4305 — C0043 Improvement of post-cataract
dry eye by 0.05% cyanocobalamine plus 0.5%
taurine and 0.5% long-chained hyaluronic acid.
Federico Solignani 1 , M. Zurria 2 , M. Rolando 1,
3
. 1 Ophthalmology Dept - Ocular surface disease
research center, University of Genoa, Genoa, Italy;
2
Medical Dept, Alfa Intes Ind Ter Spl srl, Casoria,
Italy; 3 Is.Pre Oftalmica, Genoa, Italy *CR
4306 — C0044 Title: Susceptibility Profiles
in Infectious Keratitis as an Aid in Antibiotic
Selection. Mark L. Hill, D. A. Friedman, E. Cooper,
J. Parker. Ophthalmology, UAB, Homewood, AL
4307 — C0045 Photodynamic antimicrobial
chemotherapy for methicillin-resistant
Staphylococcus aureus -in vitro, biofilm, and ex
vivo bovine keratitis model. Hsiao-sang Chu 1 , F.
Hu 1 , C. Chen 2, 3 . 1 Department of Ophthlamology,
National Taiwan University Hospital, Taipei,
Taiwan; 2 Center for Optoelectronic Biomedicine,
College of Medicine, National Taiwan University,
Taipei, Taiwan; 3 Institute of Microbiology and
Biochemistry, College of Life Science, National
Taiwan University, Taipei, Taiwan
Exhibit Hall C0046-C0100
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Cornea
419 Dry Eye and Lacrimal Gland IV
Moderator: Benjamin D. Sullivan
4308 — C0046 Tear specific potential protein
biomarker identification by 2D-DIGE based
proteomics in Dry eye syndrome associated
with Rheumatoid Arthritis. Narayanasamy
Angayarkanni 1 , S. Venkata Aluru 2 , U. Tatu 3 , S.
Agarwal 4 , B. Srinivasan 5 , G. Krishnan Iyer 6 , S.
M. Rajappa 7 , U. Vetrivel 8 , P. Padmanabhan 9 .
1
Biochemistry and Cell Biology, Vision Research
Foundation, Chennai, India; 2 Biochemistry
and Cell Biology, Vision Research Foundation,
Chennai, India; 3 Biochemistry Dept, Indian
Institute of Science, Bangalore, India; 4 Ocular
Surface Clinic, Medical Research Foundation,
Chennai, India; 5 Ocular Surface Clinic, Medical
Research Foundation, Chennai, India; 6 Ocular
Surface Clinic, Medical Research Foundation,
Chennai, India; 7 Cerebrovascular and Vasculitis
Research Foundation, Chennai, India; 8 Centre
for Bioinformatics, Vision Research Foundation,
Chennai, India; 9 Cornea Services, Medical Research
Foundation, Chennai, India
4309 — C0047 The Correlation of Muc-16 as
compared to Dry Eye Clinical Endpoints in Dry
Eye and Normal Subjects. Michael Watson, K. J.
Lane, A. Whitlock, G. W. Ousler. Ora, Inc., Andover,
MA *CR
4310 — C0048 The Use of Soluble Muc-16
(CA-125) as a Clinically Relevant Biomarker and
Endpoint in a Mouse Model of Dry Eye. Jennifer
Brackett, L. Belen, K. Violette, A. Whitlock. Ora,
Inc., Andover, MA *CR
4311 — C0049 Megalin and Cubilin Levels are
Altered in Tear-Producing Glands of Vitamin D
Receptor Null Mice. Xiaowen Lu, M. A. Watsky.
Department of Physiology, University of Tennessee
Health Science Center, Memphis, TN
4312 — C0050 Changes in corneal nerve
morphology and epithelial wound healing
after prolonged ocular dryness induced by
lacrimal gland ablation. Kamila Mizerska 1 , N.
Cuenca 2 , C. Luna 1 , S. Quirce 1 , L. Fernandez-
Sanchez 2 , I. Kovacs 3 , M. Acosta 1 , C. Belmonte 1 , J.
Gallar 1 . 1 Instituto de Neurociencias, Universidad
Miguel Hernandez-CSIC, San Juan de Alicante,
Spain; 2 Departamento de Fisiología, Genética y
Microbiología, Universidad de Alicante, Alicante,
Spain; 3 Department of Ophthalmology, Semmelweis
University, Budapest, Hungary *CR
4313 — C0051 Isolation and characterization
of progenitor cells from intact rabbit lacrimal
gland. Hong He 1 , G. Sun 1 , H. Lin 1 , M. A. Shatos 2 ,
D. A. Dartt 2 , S. C. Yiu 1, 3 . 1 Wilmer Eye Institute,
Baltimore, MD; 2 Shepens Eye Research Institute,
Boston, MA; 3 King Khaled Eye Specialist Hospital,
Riyadh, Saudi Arabia
4314 — C0052 Alterations of Tear Functions
and Ocular Surface Epithelial Differentiation in
the SOD-1 Knock- out Mouse. Murat Dogru 1, 2 , T.
Kojima 2, 1 , T. Nagata 2, 1 , A. Igarashi 1, 2 , K. Higa 1, 2 ,
Y. Satake 1 , S. Shimazaki 1 , S. Takahiko 3 , K. Tsubota 2,
1
, J. Shimazaki 1 . 1 Ophthalmology, Tokyo Dental
College, Ichikawa, Japan; 2 Ophthalmology, Keio
University School of Medicine, Tokyo, Japan;
3
Institute of Aging, Chiba University School of
Medicine, Chiba, Japan *CR
4315 — C0053 L-carnitine, Erythritol and
Betaine Suppress the Production and Activity
of Matrix Metalloproteinases in Primary
Human Corneal Epithelial Cells Exposed to
Hyperosmotic Stress. Ruzhi Deng 1, 2 , Z. Su 1, 2 , J.
Lin 1 , X. Hua 1 , D. Li 1 , S. C. Pflugfelder 1 . 1 Department
of Ophthalmology, Baylor College of Medicine,
Houston, TX; 2 Optometry and Ophthalmology,
Wenzhou Medical College, Wenzhou, China *CR
4316 — C0054 Suppressive effects of
17β-estradiol on immortalized human
meibomian gland epithelial cells. Wendy R. Kam,
D. A. Sullivan. Schepens Eye Research Institute,
Massachusetts Eye and Ear, Harvard Medical
School, Boston, MA *CR
4317 — C0055 Impact of azithromycin on
lipid accumulation in immortalized human
meibomian gland epithelial cells. Yang Liu, W.
R. Kam, J. Ding, D. A. Sullivan. Schepens Eye
Research Institute, Massachusetts Eye and Ear,
Harvard Medical School, Boston, MA *CR
4318 — C0056 A Comparative Evaluation of
Lipid-based Formulations for Dry-Eye Therapy
using a Corneal Epithelial Cell Desiccation
Model and Physicochemical Measurements.
Paramita Sarkar, Z. Marlowe, A. Walsh, B. Glass,
T. Kleiber, M. E. Cavet, K. L. Harrington, S. Davio.
R&D, Bausch & Lomb, Rochester, NY *CR
4319 — C0057 Early Clinical Development
of EBI-005, a Potent Interleukin-1 (IL-1)
Receptor-1 (R1) Blocker for Topical Ocular
Treatment of Dry Eye Disease (DED). Michael H.
Goldstein 1, 2 , G. Zarbis-Papastoitsis 2 , K. Golden 2 ,
S. Chowdhury 2 , C. Wheeler 2 , G. N. Foulks 3 ,
J. T. Kovalchin 2 , J. Agahigian 2 , E. S. Furfine 2 .
1
Ophthalmology, New England Eye Center,
Boston, MA; 2 Eleven Biotherapeutics, Cambridge,
MA; 3 Ophthalmology, University of Louisville,
Louisville, KY *CR, f
4320 — C0058 Preclinical Development of EBI-
005: a Potent Interleukin-1 (IL-1) Receptor-1
(R1) Blocker for Topical Ocular Administration
was Safe in GLP Toxicology Studies and Active
in a Mouse Model of Dry Eye Disease (DED).
Eric S. Furfine 1 , K. Collins 1 , D. Escobar 3 , C. Li 2 , P.
A. Lowden 1 , A. Masci 1 , J. Milling 1 , K. Tenneson 2 ,
G. Wolfe 4 , J. T. Kovalchin 1 . 1 R&D, Eleven
Biotherapeutics, Cambridge, MA; 2 Charles River
Laboratories, Senneville, QC, Canada; 3 Intertek,
San Diego, CA; 4 Gary Wolfe Toxicology LLC,
Herndon, VA *CR
4321 — C0059 Soft steroid topical treatment
for moderate to severe dry eye: pulse vs tapered
therapy. Edoardo Villani, C. Pirondini, F. Viola, R.
Ratiglia. UO Oculistica, Univ of Milan Fnd IRCCS
Ca’ Granda OMP, Milan, Italy
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
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