Wednesday - ARVO

4210 – 4233 – Wednesday – Posters
Wednesday Posters
8:30 am – 10:15 am
4210 — B0203 Cytotoxic Effects of the
Combination of Resveratrol and N-acetylcysteine
on Cultured Human Uveal Melanoma Cells.
Tommaso Vagaggini 1, 2 , D. Hu 2 , A. Sclafani 2 , S. A.
McCormick 2 , J. E. Roberts 1 . 1 Natural Sciences,
Fordham University, New York, NY; 2 Pathology,
New York Eye and Ear Infirmary, New York, NY
*CR
4211 — B0204 Simultaneous Inhibition of
the HGF/MET and Erk1/2 Pathways Affect
Uveal Melanoma Cell Growth and Migration.
Chandrani Chattopadhyay, E. A. Grimm, S. E.
Woodman. Melanoma Medical Oncology, UT MD
Anderson Cancer Ctr, Houston, TX *CR
4212 — B0205 Cyclooxygenase-2 (COX-2)
expression in primary uveal melanoma and the
potential role for adjuvant treatment with COX-
2 inhibitors. Lindsay E. Adam, J. B. Massengill, C.
M. Cebulla, M. H. Abdel-Rahman. Ophthalmology,
The Ohio State University, Columbus, OH
4213 — B0206 Antimicrobial Peptide
Expression and Potential Roles in Uveal
Melanoma Pathogenesis. Joseph C. Manarang,
D. C. Otteson, A. Glasser, A. R. Burns, A. M.
McDermott. College of Optometry, University of
Houston, Houston, TX
4214 — B0207 Improved Specimen Handling
for Optimizing Diagnostic Yield from Fine
Needle Aspiration Biopsy of Uveal Tumors.
Nieraj Jain, V. M. Elner, H. Demirci. University of
Michigan, Ann Arbor, MI *CR
4215 — B0208 Heterogeneity of Monosomy 3
in Fine Needle Aspiration Biopsy of Choroidal
Melanoma. Melinda Chang, N. Rao, L. Johnson, T.
McCannel. Jules Stein Eye Institute, Los Angeles,
CA
4216 — B0209 Prognostic FNAB of Uveal
Melanoma. Arun D. Singh 1, 5 , M. E. Aronow 1 , C.
V. Biscotti 2 , R. Tubbs 3 , L. Schoenfield 2 , P. Triozzi 4,
5
. 1 Ophthalmic Oncology, Cole Eye Institute,
Cleveland, OH; 2 Anatomic Pathology, Cleveland
Clinic, Cleveland, OH; 3 Molecular Pathology,
Cleveland Clinic, Cleveland, OH; 4 Solid tumor
Oncology, Cleveland Clinic, Cleveland, OH;
5
Taussig Cancer Center, Cleveland Clinic,
Cleveland, OH
4217 — B0210 Extraocular Extension of
Uveal Melanoma After Fine Needle Aspiration,
Vitrectomy, or Open Biopsy. Amy C. Schefler 1 , D.
Gologorsky 2 , B. Marr 3 , C. L. Shields 4 , I. Zeolite 5 ,
D. H. Abramson 3 . 1 Retina Consultants of Houston,
Houston, TX; 2 Geisel School of Medicine at
Dartmouth, Hanover, NH; 3 Ophthalmic Oncology,
Memorial Sloan-Kettering Cancer Center, New
York, NY; 4 Oncology Service, Wills Eye Institute,
Philadelphia, PA; 5 Ophthalmology, Universidad de
Mendoza, Mendoza, Argentina
4218 — B0211 A comparison of gene
expression profiling versus multiplex ligationdependent
probe amplification in metastatic
risk prediction in choroidal melanoma. Sarah
E. Coupland 1 , B. E. Damato 1 , H. Kalirai 1 , M.
Baudo 1 , C. Bergstrom 2 , J. R. Wells 2 , T. Kivela 3 , H.
E. Grossniklaus 2 . 1 Pathology, Univ of Liverpool/
Sydney Jones Library, Liverpool, United Kingdom;
2
Department of Ophthalmology, Emory University
School of Medicine, Atlanta, GA; 3 Department
of Ophthalmology, Helsinki University Central
Hospital, Helsinki, Finland
4219 — B0212 Prognostic implications of
GEP class 2 in clinical practice: a single center
experience with 273 cases. James J. Augsburger,
Z. M. Correa. Ophthalmology, University of
Cincinnati, Cincinnati, OH
4220 — B0213 Choroidal Melanoma
pronostication: a robust and costless classifying
system. Nathalie Cassoux 1 , L. Desjardins 1 , C.
Plancher 2 , B. Asselain 2 , C. Levy-Gabrielle 1 , L.
Lumbroso-Le Rouic 1 , M. J. Rodrigues 4 , X. Sastre 5 , S.
Piperno-Neumann 4 , J. Couturier 3 . 1 Ophthalmology,
Institut Curie, Paris, France; 2 biostatistics, Institut
Curie, Paris, France; 3 Genetics, Institut Curie, Paris,
France; 4 Oncology, Institut Curie, Paris, France;
5
Pathology, Institut Curie, Paris, France *CR
4221 — B0214 Relationship between rate of
choroidal melanoma flattening following plaque
radiotherapy and GEP class of tumor cells.
Zelia M. Correa, J. J. Augsburger. Ophthalmology,
University of Cincinnati, Cincinnati, OH
4222 — B0215 The role of Osteopontin
expression in the mechanism of invasion and
metastasis potential in Uveal Melanoma. Bin
Li. Beijing Institute of Ophthalmology, Beijing
TongRen Hospital, Beijing, China
4223 — B0216 BAP1 mutations in uveal
melanoma. Anna E. Koopmans 1, 2 , R. M. Verdijk 3 ,
T. van den Bosch 3 , M. M. van den Berg 1, 2 , J.
Vaarwater 1 , D. Paridaens 4 , E. Kilic 1 , A. de Klein 2 .
1
Ophthalmology, Erasmus Medical Centre,
Rotterdam, Netherlands; 2 Clinical Genetics,
Erasmus Medical Centre, Rotterdam, Netherlands;
3
Pathology, Erasmus Medical Centre, Rotterdam,
Netherlands; 4 The Rotterdam Eye Hospital,
Rotterdam, Netherlands
4224 — B0217 Gender differences and
estrogen and progesterone receptor expression
in uveal melanoma. Lynn Schoenfield 1 , T. Plesec 2 ,
E. Downs-Kelly 2 , M. Aronow 3 , P. Carver 2 , R.
Tubbs 2 , A. D. Singh 3 . 1 Pathology, Ohio State
University Wexner Medical Center, Columbus, OH;
2
Pathology, Cleveland Clinic, Cleveland, OH; 3 Eye
Institute, Cleveland Clinic, Cleveland, OH
4225 — B0218 Detection of circulating tumor
cells in uveal melanoma using the CellSearch ®
system. Martina Angi 1 , L. Khoja 3, 4 , B. E. Damato 2 ,
P. Lorigan 3 , C. Dive 4 , S. E. Coupland 1 , H. Kalirai 1 .
1
Department of Molecular & Clinical Cancer
Medicine, University of Liverpool, Liverpool,
United Kingdom; 2 Royal Liverpool University
Hospital, Liverpool, United Kingdom; 3 The Christie
NHS Foundation Trust, Manchester, United
Kingdom; 4 Paterson Institute for Cancer Research,
Manchester, United Kingdom
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
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4226 — B0219 Quantification of circulating
tumour cells in patients with choroidal
melanocytic tumours: correlation with clinical
risk factors. Manuel F. Bande 1 , M. Santiago 1 ,
P. Mera 1 , M. Blanco 1 , L. Muinelo-Romay 3 ,
C. Capeans 1 , M. Pardo 2 , A. Piñeiro 1 . 1 Ocular
Oncology Unit. Servizo de Oftalmoloxía.
Complexo Hospitalario Universitario de Santiago.
Universidade de Santiago de Compostela. Santiago
de Compostela. Spain, Santiago de Compostela,
Spain; 2 Grupo Obesidómica, Laboratorio de
Endocrinología Molecular y Celular, Hospital
Clínico Universitario de Santiago (CHUS/
SERGAS), Spain, Santiago de Compostela,
Spain; 3 Unit of circulating tumor cells analysis.
Traslational laboratory/ Medical Oncology
Department. Complexo Hospitalario Universitario
de Santiago de Compostela Santiago de
Compostela, Spain., Santiago de Compostela, Spain
4227 — B0220 Systemic Surveillance for
Metastases in patients with Uveal Melanoma.
Maria M. Choudhary 1 , A. Gupta 2 , J. Bena 3 , A.
D. Singh 2 . 1 Internal Medicine, Cleveland Clinic
Foundation, Cleveland, OH; 2 Department of
Ophthalmology, Cleveland Clinic Foundation,
Cleveland, OH; 3 Quantitative Health Sciences,
Cleveland Clinic Foundation, Cleveland, OH
4228 — B0221 Detecting hepatic metastases
from ocular melanoma using MRI with a
novel designed contrast agent. Hua Yang 1 , H. E.
Grossniklaus 1 , Q. Zhang 1 , S. Xue 2 , F. Pu 2 , J. Qiao 2 ,
Z. Liu 2 , R. C. Long 3 , J. Yang 2 . 1 Ophthalmology,
Emory University Eye Center, Atlanta, GA;
2
Chemistry, Georgia State University, Atlanta, GA;
3
Radiology, Emory University, Atlanta, GA
4229 — B0222 In vivo contrast-enhanced
high-frequency ultrasonography of
experimental uveal melanoma: imaging
features and histopathologic correlations. Hans
E. Grossniklaus, S. J. Kang, Q. Zhang. Dept of
Ophthal, School of Med, Emory University, Atlanta,
GA
4230 — B0223 Enhanced Depth Imaging
Optical Coherence Tomography of Choroidal
Melanoma Before and After Plaque
Radiation Therapy. Denise S. Kim, H. Demirci.
Ophthalmology & Visual Sciences, University of
Michigan Kellogg Eye Center, Ann Arbor, MI
4231 — B0224 Enhanced Depth Imaging
Optical Coherence Tomography of Tumors of
the Retina and Choroid: Comparison to B-scan
ultrasonography. Euiyong Kweon 1, 2 , J. G. Frisch 3 ,
P. G. Hovland 1 . 1 Colorado Retinal Associates,
Denver, CO; 2 Department of Ophthalmology,
Chonbuk National University Hospital, Jeonju,
Republic of Korea; 3 Roocky Vista University
Medical School, Denver, CO
4232 — B0225 EDI-OCT Findings in Unilateral
Choroidal Melanocytosis with Macular
Involvement. Sruthi Arepalli, M. Pellegrini, C.
L. Shields. Ocular Oncology, Wills Eye Institute,
Philadelphia, PA
4233 — B0226 Macular Choroidal Thickness
in Uveal Melanoma Patients treated with Plaque
Radiotherapy. Ira H. Schachar, H. Demirci.
Ophthalmology, University of Michigan, Ann
Arbor, MI