Wednesday - ARVO

Wednesday – Posters – 4189 – 4209
4189 — B0182 Mechanism of cGMP-induced
Retinal Degeneration. Tian Wang 1 , J. Chen 1 , S. H.
Tsang 2 . 1 Zilkha Neurogenetic Institute, Keck School
of Medicine, University of Southern California, Los
Angeles, CA; 2 Bernard & Shirlee Brown Glaucoma
Laboratory, Edward S. Harkness Eye Institute, and
Department of Pathology & Cell Biology, Columbia
University, New york, NY
4190 — B0183 Genetic deletion of S-opsin
prevents rapid cone degeneration in a mouse
model of Leber congenital amaurosis. Tao
Zhang 1, 2 , A. Jones 1, 2 , S. Wang 1, 2 , E. N. Pugh 3 , W.
Baehr 1, 2 , Y. Fu 1, 2 . 1 Dept of Ophthalmology and
Visual Sciences, University of Utah, Salt Lake City,
UT; 2 Neurobiology & Anatomy, University of Utah,
Salt Lake City, UT; 3 Departments of Physiology
and Cell Biology, University of California, Davis,
CA *CR
4191 — B0184 Gene Expression Alterations
in Mouse Retina with Deficiency of Cone Cyclic
Nucleotide-gated Channel Subunits CNGA3 and
CNGB3. Hongwei Ma 1 , A. Thapa 1 , L. M. Morris 1 ,
S. Michalakis 2 , M. Biel 2 , M. B. Frank 3 , M. Bebak 3 ,
X. Ding 1 . 1 The Department of Cell Biology, Univ
of Oklahoma Health Sci Ctr, Oklahoma City, OK;
2
The Center for Integrated Protein Science Munich
(CIPSM) and Department of Pharmacy - Center for
Drug Research, Ludwig-Maximilians-Universität
München, Munich, Germany; 3 The Arthritis and
Clinical Immunology Program, Oklahoma Medical
Research Foundation, Oklahoma City, OK
4192 — B0185 Inhibition of S1P degradation
rescues 661W cells from oxidative stress. Carlotta
Fabiani, P. Signorelli, A. Caretti, R. Ghidoni.
Department of Health Sciences, University of
Milan, Milan, Italy
4193 — B0186 Calcium fluxes in degenerating
pde6c w59 mutant zebrafish cones indicate a
non-apoptotic mechanism of cell death. Susan
E. Brockerhoff, E. Y. Ma, A. Lewis, G. Stearns.
Biochemistry, University of Washington, Seattle,
WA
4194 — B0187 Molecular mechanisms that
contribute to vision loss in T17M RHO mice.
Sonali R. Nashine 1 , Y. Bhootada 2 , A. S. Lewin 3 ,
M. S. Gorbatyuk 1, 2 . 1 Cell Biology and Anatomy,
Univ of North Texas Hlth Sci Ctr, Fort Worth,
TX; 2 University of Alabama, Birmingham, AL;
3
University of Florida, Gainsville, FL *CR
4197 — B0190 Interaction of Tubby-like
protein-1 (Tulp1) and Microtubule-Associated
Proteins (MAPs) in the Mouse Retina. Lindsey
A. Ebke 1 , G. H. Grossman 1 , C. D. Beight 1 , G. J.
Pauer 1 , S. A. Hagstrom 1, 2 . 1 Cole Eye Institute,
Cleveland Clinic, Cleveland, OH; 2 Department of
Ophthalmology, Cleveland Clinic Lerner College
of Medicine of Case Western Reserve University,
Cleveland, OH
4198 — B0191 The Protective effects
of Resveratrol in Experimental Retinal
Detachment. Wei Huang, G. Li, J. Qiu, P.
Gonzalez, P. Challa. Ophthalmology, Duke Eye
Center, Durham, NC
4199 — B0192 LED light source induced
retinal photoreceptor hazard in a rat model.
Yu-Man Shang 1, 2 , C. Yang 2, 3 , G. Wang 1, 4 , L. Lin 1, 2 .
1
Institute of Environmental Health, National
Taiwan University, Taipei, Taiwan; 2 Department
of Ophthalmology, National Taiwan University
Hospital, Taipei, Taiwan; 3 College of Medicine,
National Taiwan University, Taipei, Taiwan;
4
Department of Public Health, National Taiwan
University, Taipei, Taiwan
4200 — B0193 Neuroprotective effects of
norgestrel in retinitis pigmentosa: preservation
of retinal cytoarchitecture and synaptic
connectivity. Violeta Gomez-Vicente 1 , L.
Fernandez-Sanchez 1 , G. Groeger 2 , F. Doonan 2 , T.
G. Cotter 2 , N. Cuenca 1 . 1 Physiology, Genetics &
Microbiology, University of Alicante, Alicante,
Spain; 2 Biochemistry, BioSciences Institute,
University College Cork, Cork, Ireland *CR
4201 — B0194 Manipulating MSC Homing
To Enhance Its Efficacy in Preserving Vision.
Shaomei Wang 1 , Y. Tsai 1 , S. Girman 1 , L. Shen 1 ,
C. W. Morgans 2 , G. Adamus 3 , W. Xiong 1 , V.
Arumugaswami 1 , C. Svendsen 1 , B. Lu 1 . 1 Biomedical
Science, Regenerative Medicine Institute, Los
Angeles, CA; 2 Physiology & Pharmacology,
OHSU, Portland, OR; 3 Casey Eye Institute, OHSU,
Portland, OR
4202 — B0195 NecroX-5 Rescue Retinal
Degeneration Induced by N-methyl-Nnitrosourea
in Rats. Sun-Sook Paik, J. Jeon, I.
Kim. Anatomy, College of Medicine, The Catholic
University of Korea, Seoul, Republic of Korea
Exhibit Hall B0196-B0249
Wednesday, May 08, 2013 8:30 AM-10:15 AM
Anatomy/Pathology / Physiology/Pharmacology
416 Uveal Melanoma
Moderators: Tatyana Milman and Rebecca Stacy
4203 — B0196 Comparison of Two Melanoma
Cell Lines as Mouse-Models of Uveal Melanoma.
Marta M. Kilian 1 , K. U. Loeffler 1 , H. E.
Grossniklaus 2 , F. G. Holz 1 , C. Pfarrer 3 , C. Kurts 4 ,
M. C. Herwig 1 . 1 Department of Ophthalmology,
University of Bonn, Bonn, Germany; 2 Department
of Ophthalmology, Emory University, Atlanta, GA;
3
Department of Anatomy, University of Veterinary
Medicine Hannover, Hannover, Germany;
4
Institutes of Molecular Medicine and Experimental
Immunology, University of Bonn, Bonn, Germany
*CR
4204 — B0197 Calcium regulation by transient
receptor potential channels in human uveal
melanoma cells. Stefan Mergler 1 , A. Boehm 1 , R.
Derckx 1 , L. Schmelzer 1 , F. Garreis 2 , A. Riechardt 1 .
1
Department of Ophthalmology, University
Medicine Charite Berlin, Berlin, Germany;
2
Department of Anatomy II, University Erlangen-
Nuremberg, Erlangen, Germany
4205 — B0198 Unusual sodium-potassium
dynamics and Na,K-ATPase expression in Mel-
290 uveal melanoma cells. Elena B. Rodriguez de
Turco, N. A. Delamere, M. Shahidullah. Physiology,
University of Arizona, Tucson, AZ
4206 — B0199 Host Pigment Epithelium-
Derived Factor (PEDF) Prevents Progression
of Uveal Melanoma Metastasis in the Liver
and Inhibits Formation of Blood Vessels in the
Metastatic Microenvironment. John M. Lattier 1 ,
H. Yang 1 , S. Crawford 2 , H. E. Grossniklaus 1 . 1 Dept.
of Ophthalmology, Emory University, Atlanta, GA;
2
Dept. of Pathology, University of St. Louis, St.
Louis, MO
4207 — B0200 Pre-clinical analysis of
Crizotinib in MAPK independent uveal
melanoma metastases. Pieter van der Velden, M.
de Lange, M. Versluis, G. P. Luyten, M. M. Jager.
Ophthalmology, LUMC, Leiden, Netherlands
4208 — B0201 Vemurafenib as a therapeutic
option for treatment of melanoma. Simon F.
Leicht, C. M. Wertheimer, R. Liegl, A. Kampik,
K. Eibl-Lindner. Department of Ophthalmology,
Ludwig-Maximilians-University, Munich, Germany
*CR
Wednesday Posters
8:30 am – 10:15 am
4195 — B0188 Extracellular ATP accelerates
photoreceptor cell death via ligation of P2X7
receptor in retinal detachment. Shoji Notomi,
T. Hisatomi, Y. Murakami, A. Takeda, Y. Ikeda,
H. Enaida, T. Ishibashi. Ophthalmology, Kyushu
University, Fukuoka, Japan *CR
4196 — B0189 Identification and
characterization of Tubby C-terminal binding
proteins by ORF phage display. Nora B.
Caberoy 1 , G. S. Alvarado 2 , J. N. Nocillado 1 . 1 School
of Life Sciences, University of Nevada Las Vegas,
Las Vegas, NV; 2 Ophthalmology, Bascom Palmer
Eye Institute, University of Miami Miller School of
Medicinel, Miami, FL
4209 — B0202 5-Azacytidine Reduces
Growth, Invasiveness, and Clonogenicity of
Uveal Melanoma Cells and Decreases the Rate
of Metastasis. Fatemeh Rajaii, L. Asnaghi, S.
L. Merbs, J. T. Handa, C. Eberhart. Department
of Ophthalmology, Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD *CR
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
279