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<strong>Wednesday</strong><br />
May 8, 2013<br />
LIFE-CHANGING RESEARCH<br />
MAY 5 – 9 | SEATTLE
<strong>Wednesday</strong>, May 8<br />
1–2:30pm<br />
Room 8:30–10:15am 11am–12:45pm Workshop/SIG 2:45–4:30pm 5:30–6:15pm 6:30–7:15pm<br />
6A<br />
401 Biochemistry of Glaucoma [BI]<br />
#4002-4008<br />
454 What Role Do Mueller Glial Cells<br />
Play in Retinal Pathology? — SIG<br />
[RC, RE]<br />
6B<br />
402 New Ideas [GL] #4009-4015<br />
424 Genetics I [GL] #4497-4503<br />
455 Diabetic Retinopathy: Where We Are<br />
and a Path to Progress — SIG [RE]<br />
459 Neuroprotection [GL] #4938-4944<br />
6C<br />
403 Retinitis Pigmentosa II [RE]<br />
#4016-4022<br />
425 AMD: Novel and Combination<br />
Therapies [RE] #4504-4509<br />
456 Epigenetic Mechanism and Ocular<br />
Diseases —SIG [RC]<br />
460 ROP: Management [RE] #4945-<br />
4951<br />
6E<br />
404 DR: Therapeutic Effects [RE]<br />
#4023-4029<br />
426 Macular Disease other than AMD II<br />
[RE] #4510-4516<br />
461 Retinal Detachment II [RE]<br />
#4952-4958<br />
481A Cogan Award and<br />
Lecture<br />
481B Friedenwald Award and<br />
Lecture<br />
606-607<br />
405 Host Responses to Ocular<br />
Herpesvirus Infection — What Have<br />
We Learned and What Is the Future<br />
Direction? — Minisymposium [IM, CO]<br />
#4030-4034<br />
427 Ocular Immune Responses [IM]<br />
#4517-4523<br />
449 Managing Your Research, Teaching<br />
and Service: “Dollarly/Scholarly”<br />
608<br />
406 Myopia and Emmetropization [AP]<br />
#4035-4041<br />
428 Uveal Melanoma: Experimental<br />
Therapeutics [AP] #4524-4530<br />
609<br />
407 Cell Biology Impacts Lens Function<br />
[LE] #4042-4048<br />
429 A Global View of Posterior<br />
Capsule Opacification —<br />
Minisymposium [LE] #4531-4534<br />
462 Lens Proteins/Physical Chemistry<br />
[LE] #4959-4965<br />
611-614<br />
615-617<br />
618-620<br />
TCC 301/302<br />
TCC 303<br />
TCC 304<br />
408 Differentiation of Stem and iPS<br />
Cells [RC] #4049-4055<br />
409 Purine Signaling in the Eye:<br />
Role in Health and Disease —<br />
Minisymposium [PH, CO, RC]<br />
#4056-4062<br />
411 Keratoconus and Biomechanics<br />
[CO] #4069-4075<br />
412 Photoreceptors: Structure,<br />
Transduction, Signaling [VN] #4076-<br />
4082<br />
430 Physiologic Vascularization in<br />
Retinopathies [RC] #4535-4541<br />
431 Eye Care: Who’s Not Getting It and<br />
Why It Matters [CL] #4542-4548<br />
433 Stroma Keratocytes, Development<br />
and Dystrophies [CO] #4555-4561<br />
434 Genetics, Development and Aging<br />
[VN] #4562-4568<br />
450 Getting Published: The Good, the<br />
Bad, and the Ugly<br />
451 Indo-US Collaborative Vision<br />
Research Program<br />
457 Dietary Factors and Eye<br />
Health — SIG [CO, BI, RE, GL]<br />
452 Pizza with the Experts #2<br />
453 NIH-CSR Peer Review Workshop<br />
448 Multidisciplinary Ophthalmic<br />
Imaging Group: Functional Optical<br />
Imaging [MOI]<br />
463 Transplanted and Endogenous<br />
Cells as Effectors of Outer Retinal<br />
Repair — Minisymposium [RC]<br />
#4966-4970<br />
Exhibit Halls, 11am–6pm<br />
NAEVR Central,<br />
Skybridge, 9am–5pm<br />
Networking Happy Hour,<br />
Exhibit Halls, 4:30–6pm<br />
<strong>ARVO</strong> Classical Concert<br />
Nordstrom Recital Hall,<br />
Benaroya Hall<br />
8–10pm<br />
<strong>ARVO</strong> Karaoke!<br />
Club Noc Noc<br />
9pm–12Midnight<br />
TCC 305<br />
435 Neuro-Ophthalmology: Novel<br />
Treatments and Mechanisms of<br />
Disease [EY] #4569-4575<br />
465 Amblyopia: Neural Mechanisms<br />
and Treatment [EY, VI] #4978-4984<br />
TCC LL 4/5<br />
410 Spatial Vision, Visual<br />
Psychophysics and Aging II [VI]<br />
#4063-4068<br />
432 Refractive Errors, Myopia II [VI]<br />
#4549-4554<br />
458 New Paradigms and Emerging<br />
Techniques for Minimalist Macular<br />
Photocoagulation — SIG [RE]<br />
464 Advances in Ocular Genetics<br />
[GEN] #4971-4977<br />
266
<strong>Wednesday</strong>, May 8 n Posters<br />
8:30–10:15am<br />
Session Session Program Board<br />
Number Title Number Number<br />
413 AMD II, RE [RE] #4083-4129 (A0001-A0047)<br />
414 AMD III, RE [RE] #4130-4176 (A0048-A0094)<br />
415 Retinal and Photoreceptor Degeneration II: Cell Biology [RC] #4177-4202 (B0170-B0195)<br />
416 Uveal Melanoma [AP, PH] #4203-4249 (B0196-B0242)<br />
417 Accommodation and Presbyopia Correction [VI] #4250-4283 (B0287-B0320)<br />
418 Antibiotics and Corneal Disease [PH, CO] #4284-4307 (C0022-C0045)<br />
419 Dry Eye and Lacrimal Gland IV [CO] #4308-4362 (C0046-C0100)<br />
420 Neuro-Ophthalmology: Papilledema, Characterization<br />
of Rare Diseases, and Methods of Evaluation [EY] #4363-4382 (D0001-D0020)<br />
421 Eye Care [CL] #4383-4428 (D0021-D0066)<br />
422 Ocular Trauma [CL] #4429-4441 (D0114-D0126)<br />
423 Ocular Blood Flow; Surgery and Wound Healing [GL] #4442-4496 (D0182-D0236)<br />
11am–12:45pm<br />
Session Session Program Board<br />
Number Title Number Number<br />
436 AMD I, BI [BI] #4576-4594 (A0095-A0113)<br />
437 Translational Approaches in AMD and DR [RC] #4595-4627 (A0146-A0178)<br />
438 Retinal Flow and VEGF [PH, RC] #4628-4673 (B0092-B0137)<br />
439 Ocular Nanoimaging, Nanobiosensors and<br />
Nanodiagnostics [NT] #4674-4704 (B0243-B0273)<br />
440 Strabismus: Treatment Methods [EY] #4705-4717 (B0274-B0286)<br />
441 Corneal Development, Differentiation, Dystrophies,<br />
Genetics [CO] #4718-4742 (C0101-C0125)<br />
442 Surgery and Wound Healing [GL] #4743-4797 (D0127-D0181)<br />
443 Imaging III [GL] #4798-4852 (D0237-D0291)<br />
444 Choroid and Sclera Imaging [MOI] #4853-4870 (D0292-D0309)<br />
445 Imaging of Animal Models [MOI] #4871-4897 (D0310-D0336)<br />
446 Imaging I [RE] #4898-4916 (D0337-D0355)<br />
447 DME: OCT and Function [RE] #4917-4937 (D0356-D0376)<br />
2:45–4:30pm<br />
Session Session Program Board<br />
Number Title Number Number<br />
466 AMD II, BI [BI] #4985-5016 (A0114-A0145)<br />
467 Visual Functions in AMD [VI] #5017-5042 (A0179-A0204)<br />
468 Drug Delivery III [PH] #5043-5075 (B0001-B0033)<br />
469 Dysfunction in Disease: Translational Studies [VN] #5076-5100 (B0034-B0058)<br />
470 Dysfunction in Disease: Clinical Studies [VN] #5101-5133 (B0059-B0091)<br />
471 Retinal Development II: Retina and Vasculature [RC] #5134-5165 (B0138-B0169)<br />
472 Myopia II [AP] #5166-5185 (B0321-B0340)<br />
473 Non-infectious Inflammation [IM] #5186-5206 (C0001-C0021)<br />
474 Corneal Infection/Inflammation I [IM] #5207-5222 (C0126-C0141)<br />
475 Corneal Wound Repair, Transparency II [CO, BI] #5223-5237 (C0142-C0156)<br />
476 Corneal Stroma and Keratocytes [CO] #5238-5258 (C0157-C0177)<br />
477 Corneal Cross-linking and Keratoconus [CO] #5259-5305 (C0178-C0224)<br />
478 Vision Function and Quality of Life [CL] #5306-5339 (D0067-D0100)<br />
479 Oculoplastics and Orbital Disease: Prognosis,<br />
Diagnosis and Outcomes [EY] #5340-5352 (D0101-D0113)<br />
Poster board numbers indicate location:<br />
Poster Area A and B = South Exhibit Hall; Poster Area C and D = North Exhibit Hall<br />
4:30–5:30pm: All Posters — authors will be present at poster boards<br />
4:30–6pm: Networking Happy Hour in Exhibit/Poster Halls<br />
267
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268 266
<strong>Wednesday</strong> – Papers/Minisymposium – 4002 – 4021<br />
6A<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Biochemistry/Molecular Biology / Biochemistry/<br />
Molecular Biology<br />
401 Biochemistry of Glaucoma<br />
Moderators: Stanislav I. Tomarev and<br />
Ernst R. Tamm<br />
4002 — 8:30 Myocilin affects differentiation<br />
of oligodendrocytes and regulates myelination<br />
of the optic nerve via Lingo-1/RhoA signaling.<br />
Stanislav I. Tomarev 1 , H. Kwon 1 , N. Nakaya 1 , M.<br />
S. Abu-Asab 2 . 1 SRGCB, LRCMB, National Eye<br />
Institute, Bethesda, MD; 2 Histopathology Core<br />
Facility, National Eye Institute, Bethesda, MD<br />
4003 — 8:45 Genomewide DNA methylation<br />
analysis of human trabecular meshwork<br />
cells with dexamethasone stimulation. Akira<br />
Matsuda, N. Ebihara, A. Murakami. Department<br />
of Ophthalmology, Juntendo Univ School of Med,<br />
Tokyo, Japan *CR<br />
4004 — 9:00 Stabilization of Myocilin with<br />
Small Molecules Prevents Its Aggregation.<br />
Raquel L. Lieberman, S. E. Hill, R. K. Donegan, K.<br />
C. Turnage. School of Chemistry & Biochemistry,<br />
Georgia Institute of Technology, Atlanta, GA<br />
4005 — 9:15 PGC-1alpha Signaling Regulates<br />
Retinal Ganglion Cell Injury Responses And<br />
Atrocyte Reactivity. Jeremy M. Sivak 1, 2 , X. Guo 1 ,<br />
S. Dason 2 , A. Nahirny 1 . 1 Vision Sciences, Toronto<br />
Western Hospital, University Health Network,<br />
Toronto, ON, Canada; 2 Ophthalmology and Vision<br />
Sciences, University of Toronto, Toronto, ON,<br />
Canada<br />
4006 — 9:30 Subcellular mislocalization and<br />
loss of function of mutant Gpnmb proteins.<br />
Alexander C. Theos. Human Science, Georgetown<br />
University, Washington, DC<br />
4007 — 9:45 Cochlin and phosphatidylcholines<br />
interact with SLC44A2 channel on the<br />
trabecular meshwork cells. Sanjoy K.<br />
Bhattacharya, M. Martinez, A. Aljohani, R. K. Lee.<br />
Bascom Palmer Eye Institute, Univ of Miami Miller<br />
Sch of Med, Miami, FL *CR<br />
4008 — 10:00 Disruption of the homeostatic<br />
balance between TGF-β and BMPs in the<br />
outflow tissues of the CTGF-based Glaucoma<br />
mouse model. Sabrina Kuespert, E. R. Tamm, R.<br />
Fuchshofer. University Regensburg, Institut of<br />
Human Anatomy and Embryology, Regensburg,<br />
Germany<br />
6B<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Glaucoma<br />
402 New Ideas<br />
Moderators: Jonathan G. Crowston, Peng T. Khaw<br />
and George A. Cioffi<br />
4009 — 8:30 Glucose-induced Temporary<br />
Visual Recovery in Human Glaucoma: A<br />
Prospective, Double-blind, Randomised Study.<br />
Robert J. Casson, G. Chidlow, A. Ebneter, G.<br />
Han, J. Gilhotra, J. P. Wood. SA Institute of<br />
Ophthalmology, SA Inst of Ophthalmol, Adelaide<br />
Univ, Adelaide, SA, Australia f<br />
4010 — 8:45 Radiation Treatment Does Not<br />
Protect the Rat Optic Nerve from Elevated<br />
Intraocular Pressure (IOP)-Induced Injury.<br />
Elaine C. Johnson, W. Cepurna, J. C. Morrison.<br />
Ophthalmology, Casey Eye Institute-OHSU,<br />
Portland, OR<br />
4011 — 9:00 Estrogen Pathway Polymorphisms<br />
in Relation to Primary Open Angle Glaucoma:<br />
A Gender-Specific Analysis from Patients in the<br />
United States. Louis R. Pasquale 1, 2 , S. Loomis 1 ,<br />
B. Yaspan 3 , J. H. Kang 2 , R. N. Weinreb 6 , J. E.<br />
Richards 7 , M. A. Hauser 4 , J. L. Haines 5 , J. L.<br />
Wiggs 1 . 1 Ophthalmology, Mass Eye & Ear Infirmary,<br />
Boston, MA; 2 Medicine, Brigham and Women’s<br />
Hospital, Boston, MA; 3 Genentech, Inc, San<br />
Francisco, CA; 4 Ophthalmology, Duke University,<br />
Durham, NC; 5 Center for Human Genetics<br />
Research, Vanderbilt University, Nashville,<br />
TN; 6 Ophthalmology, UCSD, San Diego, CA;<br />
7<br />
Ophthalmology and Visual Sciences, University of<br />
Michigan, Ann Arbor, MI *CR<br />
4012 — 9:15 A Novel Device for Clinical<br />
Measurement of Corneal Elasticity. Christopher<br />
K. Leung 1 , C. Ye 1 , M. Ko 2 , L. Leung 2 , D. Lam 2 .<br />
1<br />
Ophthalmology and Visual Sciences, The Chinese<br />
University of Hong Kong, Hong Kong, Hong Kong;<br />
2<br />
Mechanical Engineering, Hong Kong University of<br />
Science and Technology, Hong Kong, Hong Kong<br />
*CR<br />
4013 — 9:30 A Potential Role for the<br />
Hypothalamic Orexin System in Mediating<br />
Intraocular Pressure Fluctuations. Brian<br />
C. Samuels 1 , N. Hammes 1 , P. L. Johnson 2 , A.<br />
Shekhar 3, 4 . 1 Department of Ophthalmology, Eugene<br />
& Marilyn Glick Eye Inst, Ind Univ, Indianapolis,<br />
IN; 2 Department of Anatomy, Indiana University,<br />
Indianapolis, IN; 3 Department of Psychiatry,<br />
Indiana University, Indianapolis, IN; 4 Clinical and<br />
Translational Sciences Institute, Indiana University,<br />
Indianapolis, IN *CR<br />
4014 — 9:45 Pulse-induced Trabecular<br />
Meshwork (TM) Movement in Humans:<br />
Characterization by Phase-sensitive OCT<br />
(PhS-OCT). Murray A. Johnstone 2 , P. Li 1 , T. T.<br />
Shen 1, 2 , R. K. Wang 1 . 1 Bioengineering, University<br />
of Washington, Seattle, WA; 2 Ophthalmology,<br />
University of Washington, Seattle, WA *CR<br />
4015 — 10:00 A quantitative approach to the<br />
analysis of visual field defect location and its<br />
relationship to measures of disability. Michael V.<br />
Boland, P. Y. Ramulu, K. S. Arora, J. L. Jefferys, D.<br />
S. Friedman. Wilmer Eye Institute, Johns Hopkins<br />
University, Baltimore, MD *CR<br />
6C<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Retina<br />
403 Retinitis Pigmentosa II<br />
Moderators: Yasuhiro Ikeda and David J. Wilson<br />
4016 — 8:30 Long-term efficacy and safety of<br />
treatment of retinitis pigmentosa with valproic<br />
acid. Christine N. Kay, S. Bhalla. Ophthalmology,<br />
University of Florida, Gainesville, FL<br />
4017 — 8:45 Visual Function Improvements<br />
following Electroacupuncture for Retinitis<br />
Pigmentosa. Ava K. Bittner 1 , J. Gould 3 , C.<br />
Rozanski 1 , A. Rosenfarb 2 , M. R. DeJong 3 , A.<br />
Benavente-Perez 4 , G. Dagnelie 1 . 1 Ophthalmology,<br />
Johns Hopkins University, Baltimore, MD;<br />
2<br />
Acupuncture Health Associates, Westfield, NJ;<br />
3<br />
Johns Hopkins University, Baltimore, MD; 4 SUNY<br />
College of Optometry, New York, NY f<br />
4018 — 9:00 Evaluation of peripheral retinal<br />
vasculitis in retinitis pigmentosa using wide-field<br />
fluorescein angiography. Matthew B. Kaufman 1, 2 ,<br />
C. A. Medina-Mendez 1, 2 , T. R. Friberg 1, 2 , A. W.<br />
Eller 1, 2 . 1 Ophthalmology, UPMC Eye Center,<br />
Pittsburgh, PA; 2 Ophthalmology, University of<br />
Pittsburgh School of Medicine, Pittsburgh, PA *CR<br />
4019 — 9:15 Inheritance of Retinitis<br />
Pigmentosa: Update in the Era of Genetic<br />
Testing. Kari E. Branham, J. Huang, K. T.<br />
Jayasundera, J. R. Heckenlively. Ophthalmology<br />
and Visual Sciences, University of Michigan, Ann<br />
Arbor, MI *CR<br />
4020 — 9:30 Ultra wide-field autofluorescence<br />
is useful to evauluate residual retinal functions<br />
in patients with Retinitis Pigmentosa. Shuntaro<br />
Ogura, T. Yasukawa, M. Yoshida, Y. Ogura.<br />
Department of Ophthalmology, Nagoya City Univ<br />
Medical School, Nagoya, Japan<br />
4021 — 9:45 Recombinant Human Nerve<br />
Growth Factor Protects Photoreceptor<br />
Degeneration in a Rat Model of Inherited<br />
Retinitis Pigmentosa. Luigi Aloe 1 , P. Bianchi 1 ,<br />
M. Rocco 1 , A. Micera 2 , A. Lambiase 3 , S. Bonini 3 .<br />
1<br />
Institute of Neurobiology and Molecular Medicine,<br />
National Research Council, Rome, Italy; 2 G.B.<br />
Bietti IRCCS, Rome, Italy; 3 Department of<br />
Ophthalmology, University of Rome, Campus<br />
Biomedico, Rome, Italy *CR<br />
<strong>Wednesday</strong> Papers/<br />
Minisymposium<br />
8:30 am – 10:15 am<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
269
4022 – 4039 – <strong>Wednesday</strong> – Papers/Minisymposium<br />
<strong>Wednesday</strong> Papers/<br />
Minisymposium<br />
8:30 am – 10:15 am<br />
4022 — 10:00 Nonsyndromic RP Due to BBS2<br />
Mutations. Meghan J. Marino 1 , G. J. Pauer 1 ,<br />
J. Chiang 3 , S. A. Hagstrom 1, 2 , E. I. Traboulsi 1, 2 .<br />
1<br />
Ophthalmic Research, Cole Eye Institute,<br />
Cleveland Clinic, Cleveland, OH; 2 Ophthalmology,<br />
Cleveland Clinic Lerner College of Medicine Case<br />
Western Reserve University, Cleveland, OH; 3 Casey<br />
Eye Institute Molecular Diagnostics Laboratory,<br />
Portland, OR *CR<br />
6E<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Retina<br />
404 DR: Therapeutic Effects<br />
Moderator: Peter A. Campochiaro<br />
4023 — 8:30 Intravitreal ranibizumab (RBZ)<br />
suppresses posterior retinal nonperfusion (RNP)<br />
in patients with diabetic macular edema (DME).<br />
Peter A. Campochiaro 1 , C. Wykoff 2 , D. Chen 3 , H.<br />
Shapiro 4 , J. S. Ehrlich 5 , R. Rubio 6 . 1 Ophthalmology<br />
and Neuroscience, Johns Hopkins Wilmer Eye<br />
Inst, Baltimore, MD; 2 Retina Consultants of<br />
Houston, Houston, TX; 3 Genentech, Inc., South<br />
San Francisco, CA; 4 Genentech, Inc., South<br />
San Francisco, CA; 5 Genentech, Inc., South San<br />
Francisco, CA; 6 Genentech, Inc., South San<br />
Francisco, CA *CR, f<br />
4024 — 8:45 Intensive Diabetes Therapy<br />
Reduces Ocular Surgeries in Patients with<br />
Type 1 Diabetes: twenty-eight year followup of<br />
the Diabetes Control and Complications Trial<br />
/ Epidemiology of Diabetes Interventions and<br />
Complications study (DCCT/EDIC). Lloyd P.<br />
Aiello 1, 2 , W. Sun 5 , P. A. Cleary 5 , J. M. Lachin 5 ,<br />
S. Gangaputra 3 , R. Klein 4 , A. Das 7 , S. Kiss 6 , A.<br />
Domalpally 3 , R. P. Danis 3 . 1 Beetham Eye Institute,<br />
Joslin Diabetes Center, Boston, MA; 2 Department<br />
of Ophthalmology, Harvard Medical School,<br />
Boston, MA; 3 Fundus Photograph Reading Center,<br />
University of Wisconsin, Madison, WI; 4 Department<br />
of Ophthalmology and Visual Sciences, University<br />
of Wisconsin School of Medicine and Public<br />
Health, Madison, WI; 5 Biostatistics Center, George<br />
Washington University, Rockville, MD; 6 Clinical<br />
Research, Weill Cornell Medical College, New<br />
York, NY; 7 University of New Mexico School of<br />
Medicine, Albuquerque, NM *CR, f<br />
4025 — 9:00 Canadian PhIIIb study:<br />
ranibizumab combination/monotherapy in visual<br />
impairment due to DME: Preliminary Analysis.<br />
Thomas Sheidow 1, 2 , A. R. Berger 3 , F. deTakacsy 4 ,<br />
R. Li 4 , B. Rehel 5 , A. Courseau 4 . 1 Ivey Eye Institute,<br />
London, ON, Canada; 2 Ophthalmology, Western<br />
University, London, ON, Canada; 3 St. Michael’s<br />
Hospital, Toronto, ON, Canada; 4 Novartis<br />
Pharmaceuticals Canada Inc., Dorval, QC, Canada;<br />
5<br />
Everest Clinical Research Services, Inc., Markham,<br />
ON, Canada *CR, f<br />
4026 — 9:15 Baseline Predictors of<br />
improvement in self-reported visual function<br />
following treatment with ranibizumab in patients<br />
with diabetic macular edema. Rohit Varma 1 , N.<br />
M. Bressler 2 , C. Dolan 3 , L. Yau 3 , J. F. Ward 3 , S.<br />
Colman 3 . 1 Ophthalmology and Visual Sciences,<br />
University of Illinois at Chicago Eye and Ear<br />
Infirmary, Chicago, IL; 2 Retina Division, Wilmer<br />
Eye Institute, Johns Hopkins University School of<br />
Medicine, Baltimore, MD; 3 Genentech, Inc., South<br />
San Francisco, CA *CR, f<br />
4027 — 9:30 Effect of Statins and Diabetes<br />
Therapy (Oral Hypoglycemics and Insulin)<br />
on the Outcomes of Patients Treated with<br />
Ranibizumab and/or Laser Therapy. Mohammad<br />
A. Sadiq 1 , M. Hassan 1 , Y. J. Sepah 1 , G. K. Loh 2, 1 , S.<br />
Kherani 1 , M. Hanout 1 , R. E. Annam 1 , M. Ansari 1 ,<br />
D. V. Do 1 , Q. Nguyen 1 . 1 Retinal Imaging Research<br />
and Reading Center, Wilmer Eye Institute. Johns<br />
Hopkins University, Baltimore, MD; 2 Division<br />
of medicine, University College London Medical<br />
School, London, United Kingdom *CR, f<br />
4028 — 9:45 Effects of Intravitreal<br />
Ranibizumab on Diabetic Retinopathy Severity:<br />
36 Month Data from the RISE and RIDE Phase<br />
III Trials. Jason S. Ehrlich 1 , A. Domalpally 2 ,<br />
L. Yau 1 , J. J. Hopkins 1 , M. S. Ip 2 . 1 Genentech,<br />
Inc, South San Francisco, CA; 2 Department of<br />
Ophthalmology and Visual Sciences, University of<br />
Wisconsin Medical School, Madison, WI *CR, f<br />
4029 — 10:00 RELIGHT - Ranibizumab<br />
treatment of diabetic macular oedema with<br />
bimonthly monitoring after a phase of initial<br />
Treatment. Ian A. Pearce. Royal Liverpool<br />
University Hospital, St Paul’s Eye Unit, Liverpool,<br />
United Kingdom *CR, f<br />
606/607<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Immunology/Microbiology / Cornea<br />
405 Host Responses to Ocular<br />
Herpesvirus Infection - What Have<br />
We Learned and What Is the Future<br />
Direction? - Minisymposium<br />
This session will cover current data and concepts<br />
from clinical presentation, immune response/<br />
regulation to virus infection, and development of<br />
novel treatment strategies.<br />
Moderators: Daniel J. Carr and Barry T. Rouse<br />
4030 — 8:30 Insights into Natural History<br />
of HSV Infections in the Era of Changing<br />
Epidemiology. Anna Wald. University of<br />
Washington, Seattle, WA *CR<br />
4031 — 9:00 Herpes Simplex Virus Evasion of<br />
Host Immunity and the Autophagy Response.<br />
David A. Leib. Microbiology and Immunology HB<br />
7556, Dartmouth Medical School, Lebanon, NH<br />
4032 — 9:20 Chronic Murine Cytomegalovirus<br />
Infection results in more severe Experimental<br />
Choroidal Neovascularization. Richard D. Dix.<br />
Department of Biology, Georgia State University,<br />
Atlanta, GA<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
270<br />
4033 — 9:40 Pathogenesis of Herpes<br />
Stromal Keratitis - A Focus on Corneal<br />
Neovascularization. Barry T. Rouse. Pathobiology,<br />
Univ of Tennessee Coll of Vet Med, Knoxville, TN<br />
4034 — 10:00 Discussion. Todd P. Margolis.<br />
UCSF Proctor Foundation, Univ of California-San<br />
Francisco, San Francisco, CA *CR<br />
608<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Anatomy/Pathology<br />
406 Myopia and Emmetropization<br />
Moderators: Frank Schaeffel and Chi-ho To<br />
4035 — 8:30 Distribution and Determinants<br />
of Eye Size and Shape in Newborn Children:<br />
a Magnetic Resonance Imaging Analysis.<br />
Laurence S. Lim 1, 2 , P. Tan 2 , G. Chong 2 , Y. Chong 2 ,<br />
M. V. Fortier 3 , P. Gluckman 4, 5 , S. Saw 2, 1 , A. Qiu 2 .<br />
1<br />
Ophthalmology, Singapore National Eye Center,<br />
Singapore, Singapore; 2 National University of<br />
Singapore, Singapore, Singapore; 3 KK Women’s<br />
and Children’s Hospital, Singapore, Singapore;<br />
4<br />
Singapore Institute for Clinical Sciences, the<br />
Agency for Science, Technology and Research,<br />
Singapore, Singapore; 5 Liggins Institute, University<br />
of Auckland, Auckland, New Zealand *CR<br />
4036 — 8:45 Central retinal thickness and<br />
axial length in the Copenhagen Child Cohort<br />
2000 study: data from 432 11-year-old children.<br />
Xiao Q. Li 1 , M. Larsen 1 , I. C. Munch 2 . 1 Department<br />
of Ophthalmology, Glostrup Hospital, Glostrup,<br />
Denmark; 2 Department of Ophthalmology, Roskilde<br />
Hospital, Roskilde, Denmark<br />
4037 — 9:00 Neurochemical Ablation of<br />
Peripheral Glucagonergic Amacrine Cells in<br />
the Chick Retina and its Effects on Axial Eye<br />
Growth and Refractive Error. Diane Nava 1, 2 , A.<br />
Chang 2 , L. A. Ostrin 2 , Z. Chen 2, 3 , C. F. Wildsoet 1, 2 .<br />
1<br />
Vision Science Group, UC Berkeley, Berkeley,<br />
CA; 2 Center for Eye Disease and Development,<br />
UC Berkeley School of Optometry, Berkeley, CA;<br />
3<br />
Department of Opthalmology and Vision Science,<br />
Fudan University Eye and ENT Hospital, Shanghai,<br />
China<br />
4038 — 9:15 Ocular growth guided by dual<br />
focal fresnel lenses requires an intact optic<br />
nerve. Sally A. McFadden 1 , D. Y. Tse 2 , C. To 2 , C.<br />
F. Wildsoet 3 . 1 School of Psychology, University of<br />
Newcastle, Callaghan, NSW, Australia; 2 School of<br />
Optometry, The Hong Kong Polytechnic University,<br />
Kowloon, Hong Kong; 3 School of Optometry,<br />
University of California, Berkeley, CA<br />
4039 — 9:30 Effects of Long-Wavelength-<br />
Pass Filters on Refractive Development in<br />
Rhesus Monkeys. Earl L. Smith 1, 2 , L. Hung 1, 2 ,<br />
B. Arumugam 1, 2 , J. Huang 1, 2 , M. Neitz 3 , J. Neitz 3 .<br />
1<br />
College of Optometry, University of Houston,<br />
Houston, TX; 2 Vision Cooperative Research<br />
Centre, Sydney, NSW, Australia; 3 Department of<br />
Ophthalmology, University of Washington Medical<br />
School, Seattle, WA *CR
4040 — 9:45 The role of central retina in<br />
chicks during form deprivation myopia. Jianchao<br />
Wang 1, 2 , R. Chun 1 , K. Li 1 , Q. Liu 1, 2 , C. To 1, 2 .<br />
1<br />
Laboratory of Experimental Optometry, Centre<br />
for Myopia Research, School of Optometry, The<br />
Hong Kong Polytechnic University, HongKong,<br />
China; 2 State Key Laboratory of Ophthalmology,<br />
Zhongshan Ophthalmic Centre, Sun Yat-sen<br />
University, Guangzhou, China<br />
4041 — 10:00 Photoreceptor Outer Retinal<br />
Function as the Primary Controller of Ocular<br />
Growth. David P. Crewther 1, 2 , S. N. Kiely 2 , M.<br />
J. Murphy 2 , N. Riddell 2 , S. G. Crewther 2 . 1 Centre<br />
for Human Psychopharmacology, Swinburne<br />
Univ of Technology, Melbourne, VIC, Australia;<br />
2<br />
Psychological Science, La Trobe University,<br />
Melbourne, VIC, Australia<br />
4048 — 10:00 Linking the optical properties of<br />
the lens to its cellular physiology: a multimodal<br />
imaging and modelling approach. Ehsan Vaghefi<br />
Rezaei 1 , A. Kim 1 , P. J. Donaldson 2, 1 . 1 Department<br />
of Optometry and Vision Sciences, University<br />
of Auckland, Auckland, New Zealand; 2 School<br />
of Medical Sciences, University of Auckland,<br />
Auckland, New Zealand<br />
611-614<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Retinal Cell Biology<br />
408 Differentiation of Stem and<br />
iPS Cells<br />
<strong>Wednesday</strong> – Papers/Minisymposium – 4040 – 4059<br />
4054 — 9:45 Investigating the pathophysiology<br />
of USH2A associated retinal degeneration with<br />
patient specific iPSCs. Budd A. Tucker 1 , R. F.<br />
Mullins 1 , K. R. Anfinson 1 , L. M. Affatigato 1 , J.<br />
A. Halder 1 , P. M. Brzeskiewicz 1 , E. M. Stone 1, 2 .<br />
1<br />
Ophthalmology, Inst for Vision Rsrch, Univ of<br />
Iowa, Iowa City, IA; 2 HHMI Investigator, Iowa<br />
City, IA *CR<br />
4055 — 10:00 Differentiation of iPS-RPE<br />
cells from a patient with clinical anophthalmia.<br />
Amanda-Jayne F. Carr 1 , L. Ho 2 , L. Chen 1 , G. Selva<br />
Raj 2 , A. A. Vugler 1 , M. A. Shboul 2 , A. Colman 2 ,<br />
B. Reversade 2 , P. J. Coffey 1 . 1 Division of ORBIT,<br />
Institute of Ophthalmology, University College<br />
London, London, United Kingdom; 2 Dept. of<br />
Paediatrics, A*STAR Institute of Medical Biology,<br />
Biopolis, Singapore<br />
609<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Lens<br />
407 Cell Biology Impacts<br />
Lens Function<br />
Moderators: Marc Kantorow and A S. Menko<br />
4042 — 8:30 JNK inactivation suppresses<br />
mTOR (Mammalian Target of Rapamycin)<br />
pathway to induce loss of nuclei and organelles<br />
in the lens through Autophagy. Subhasree Basu 1 ,<br />
S. Rajakaruna 1 , B. A. Reyes 2 , E. J. Van Bockstaele 2 ,<br />
A. S. Menko 1, 3 . 1 Pathology Anatomy & Cell<br />
Biology, Thomas Jefferson University, Philadelphia,<br />
PA; 2 Neuroscience, Thomas Jefferson University,<br />
Philadelphia, PA; 3 Wills Vision Research Center at<br />
Jefferson, Philadelphia, PA<br />
4043 — 8:45 Autophagy mediates<br />
mitochondrial degradation in the developing<br />
and adult eye lens. Marc Kantorow 1 , D. Chauss 1 ,<br />
A. Mohamed 2 , K. Gilliland 3 , L. A. Brennan 1 , M. J.<br />
Costello 3 . 1 Biomedical Sciences, Florida Atlantic<br />
University, Boca Raton, FL; 2 L. V. Prasad Eye<br />
Institute, Hydrabad, India; 3 Cell Biology and<br />
Physiology, University of North Carolina, Chapel<br />
Hill, NC<br />
4044 — 9:00 Loss of Pten Rescues Akt<br />
Phosphorylation, Apoptosis and Size in Fgfr2<br />
Deficient Lenses. Blake R. Chaffee, M. R. Leonard,<br />
B. D. Wagner, M. L. Robinson. Zoology, Miami<br />
University, Oxford, OH<br />
4045 — 9:15 Role of Birc7 in the Mouse Lens.<br />
Alicia De Maria, S. Bassnett. Ophthalmology and<br />
Visual Sciences, Washington University, St Louis,<br />
MO<br />
4046 — 9:30 The Optical Quality of Inhibitor-<br />
Treated Avian Crystalline Lenses. Gah-Jone<br />
Won, V. Choh. School of Optometry, University of<br />
Waterloo, Waterloo, ON, Canada<br />
4047 — 9:45 Estimation of Ciliary Muscle<br />
Forces Required to Induce Corneal Deformation.<br />
Robert P. Wilkes, M. A. Reilly. Biomedical<br />
Engineering, University of Texas at San Antonio,<br />
San Antonio, TX<br />
Moderators: Jason S. Meyer and G Astrid Limb<br />
4049 — 8:30 MITF regulation of early cell fate<br />
in a human embryonic stem cell model of retinal<br />
development. Elizabeth E. Capowski 1 , J. Simonett 1 ,<br />
E. Clark 1 , L. S. Wright 1 , I. Pinilla Lozano 2, 3 , J.<br />
Phillips 1 , K. Wallace 1 , D. M. Gamm 4, 5 . 1 Waisman<br />
Center, University of Wisconsin-Madison, Madison,<br />
WI; 2 Ophthamology, University Hospital Lozano<br />
Blesa, Zaragoza, Spain; 3 IIS Aragon, Aragon Health<br />
Sciences Institute, Zaragoza, Spain; 4 Ophthamology<br />
and Visual Sciences, University of Wisconsin-<br />
Madison, Madison, WI; 5 McPherson Eye Research<br />
Institute, University of Wisconsin-Madison,<br />
Madison, WI *CR<br />
4050 — 8:45 Simplified and Efficient<br />
Generation of Photoreceptors from Human<br />
Pleuripotent Stem Cells. Joo Young Shin, H. Yu.<br />
Ophthalmology, Seoul National University, Seoul,<br />
Republic of Korea<br />
4051 — 9:00 Improving Human RPE<br />
Differentiation from iPS Cells: Lessons from<br />
Mouse Eye Development. Kapil Bharti 1 , J.<br />
Davis 1 , B. Corneo 2 , Q. Wan 1 , K. J. Miyagishima 1 ,<br />
S. Temple 2 , S. S. Miller 1 . 1 NEI, National Institutes<br />
of Health, Bethesda, MD; 2 National Eye Institute,<br />
National Institutes of Health, Bethesda, MD *CR<br />
4052 — 9:15 Investigating the role of VSX2<br />
(CHX10) in human retinogenesis using iPS cells.<br />
Joe Phillips 1, 2 , E. Perez 1 , K. Wallace 1 , J. M. Martin 1 ,<br />
R. Singh 1 , E. E. Capowski 1 , L. S. Wright 1 , E. Clark 1 ,<br />
E. F. Percin 3 , D. M. Gamm 1, 2 . 1 Waisman Center,<br />
University of Wisconsin, Madison, WI; 2 McPherson<br />
Eye Research Institute, University of Wisconsin,<br />
Madison, WI; 3 Medical Genetics, Gazi University,<br />
Ankara, Turkey *CR<br />
4053 — 9:30 Differentiation of Human<br />
Protein Induced Pluripotent Stem Cells (piPS)<br />
Towards a Retinal Pigment Epithelium (RPE)<br />
Fate. Jie Gong, M. A. Fields, L. V. Del Priore.<br />
Ophthalmology, MUSC Storm Eye Institute,<br />
Charleston, SC<br />
618-620<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Physiology/Pharmacology / Cornea /<br />
Retinal Cell Biology<br />
409 Purine Signaling in the Eye: Role<br />
in Health and Disease - Minisymposium<br />
The field of purine signaling is rapidly expanding,<br />
with a great diversity of roles in health and<br />
disease. Purine receptors (P1 Adenosine and P2<br />
Purine/Nucleotide receptors) have been identified<br />
throughout the tissues of the eye with proposed<br />
roles in processes including control of intraocular<br />
pressure, visual processing and mediation of<br />
inflammatory responses. This symposium explores<br />
purine signaling in ocular tissues: lacrimal gland,<br />
trabecular meshwork, lens and retina. Questions<br />
are asked about the role of purine signaling in<br />
healthy ocular tissue, including in development<br />
and in retinal processing, as well as addressing the<br />
consequences of dysregulation to ocular health in<br />
disease, including dry eye and glaucoma. Purine<br />
receptors as putative drug targets for ocular disease<br />
are also discussed.<br />
Moderators: Julie Sanderson, Claire H. Mitchell<br />
and Claudio Bucolo<br />
4056 — 8:30 Introduction to Purine Signaling.<br />
Julie Sanderson. School of Pharmacy, University of<br />
East Anglia, Norwich, United Kingdom<br />
4057 — 8:45 Purine Signaling in the<br />
Trabecular Meshwork: A Regulator of<br />
Intraocular Pressure. Mortimer M. Civan.<br />
Physiology-Richards Bldg, Univ of Pennsylvania<br />
Sch of Med, Philadelphia, PA<br />
4058 — 9:00 Purinergic Receptors in Lacrimal<br />
Gland Health and Dry Eye Disease. Darlene A.<br />
Dartt. Schepens Eye Research Institute, Boston,<br />
MA<br />
4059 — 9:15 TRPV4 and Hemichannels<br />
Cooperate to Play a Critical Role in Purine<br />
Signaling in the Lens. Nicholas A. Delamere.<br />
Physiology, University of Arizona, Tucson, AZ<br />
<strong>Wednesday</strong> Papers/<br />
Minisymposium<br />
8:30 am – 10:15 am<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
271
4060 – 4080 – <strong>Wednesday</strong> – Papers/Minisymposium<br />
4060 — 9:30 Purine Signaling in Müller<br />
Cells During Development and in the Adult<br />
Retina in Health and Disease. Antje Grosche.<br />
Pathophysiology of Neuroglia, University of<br />
Leipzig, Leipzig, Germany<br />
4061 — 9:45 Purinergic Signaling in Retinal<br />
Processing. Thomas E. Salt. Visual Neuroscience,<br />
UCL Institute of Ophthalmology, London, United<br />
Kingdom *CR<br />
4062 — 10:00 Purines and Low Grade<br />
Inflammation at Either End of the Retina; ATP<br />
and Cytokines in Both RGCs and RPE. Claire H.<br />
Mitchell. Anatomy and Cell Biology, University of<br />
Pennsylvania Library, Philadelphia, PA *CR<br />
TCC LL 4/5<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Visual Psychophysics / Physiological Optics<br />
410 Spatial Vision, Visual<br />
Psychophysics and Aging II<br />
TCC 303<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Cornea<br />
411 Keratoconus and Biomechanics<br />
Moderator: Shukti Chakravarti<br />
4069 — 8:30 Mutations in the zinc finger<br />
protein gene, ZNF469 contribute to the<br />
pathogenesis of keratoconus. Andrea L. Vincent 1, 2 ,<br />
C. Jordan 1, 2 , B. Hay 1 , A. J. Richards 1 , C. N.<br />
McGhee 1, 2 . 1 Ophthalmology, New Zealand National<br />
Eye Centre, University of Auckland, Auckland,<br />
New Zealand; 2 Eye Department, Greenlane Clinical<br />
Centre, Auckland District Health Board, Auckland,<br />
New Zealand *CR<br />
4070 — 8:45 Matrix Metalloproteinase-9 drives<br />
disease progression of Keratoconus. Ashwini<br />
Ranganath, R. Shetty, S. D’Souza, K. Wadia, D.<br />
Das, A. Ghosh. cornea and refractive surgery,<br />
Narayana Nethralaya eye hospital, Bangalore, India<br />
f<br />
4071 — 9:00 Novel proteins and metabolites<br />
for the identification of Keratoconus disease.<br />
Dimitrios Karamichos 1, 2 , J. Hjortdal 4 , A. E.<br />
Hutcheon 1, 2 , J. M. Asara 3 , J. D. Zieske 1, 2 .<br />
1<br />
Schepens Eye Research Institute/MEE, Boston,<br />
MA; 2 Department of Ophthalmology, Harvard<br />
Medical School, Boston, MA; 3 Division of<br />
Signal Transduction/Mass Spectrometry Core,<br />
Beth Israel Deaconess Medical Center, Harvard<br />
Medical School, Boston, MA; 4 Department of<br />
Ophthalmology, Aarhus University Hospital, Aarhus<br />
C, Denmark *CR<br />
4072 — 9:15 Evaluation of transcorneal<br />
iontophoresis of riboflavin for corneal<br />
collagen cross-linking. Alejandro Arboleda 1, 2 , L.<br />
Kowalczuk 3 , M. Savoldelli 4 , C. Klein 3 , S. Ladraa 3 ,<br />
J. A. Parel 1, 4 , F. F. Behar-Cohen 3, 4 . 1 Ophthalmic<br />
Biophysics Center, Dept. of Ophthalmology,<br />
Bascom Palmer Eye Institute, University of<br />
Miami Miller School of Medicine, Miami, FL;<br />
2<br />
Dept. of Biomedical Engineering, University<br />
of Miami College of Engineering, Coral Gables,<br />
FL; 3 INSERM UMRS872: Physiopathology of<br />
Ocular Diseases: Therapeutic Innovations, Centre<br />
de Recherche des Cordeliers, Pierre et Marie<br />
Curie University, Paris Descartes University,<br />
Paris, France; 4 AP-HP Hôtel-Dieu, Dept. of<br />
Ophthalmology, Sorbonne Paris Cité, Paris<br />
Descartes University, Faculty of Medicine, Paris,<br />
France *CR<br />
4073 — 9:30 Corneal biomechanical<br />
properties in corneal collagen cross-linking<br />
(CXL) at high fluences. Arthur Hammer 1 , O.<br />
Richoz 1 , D. Tabibian 1 , F. Hoogewoud 1 , F. Hafezi 1, 2 .<br />
1<br />
Ophthalmology, Geneva University Hospitals,<br />
Geneva, Switzerland; 2 Ophthalmology, Doheny<br />
Eye Institute, Keck school of medicine USC, Los<br />
Angeles, CA *CR<br />
4074 — 9:45 Soluble collagen protects the<br />
corneal fibrils during riboflavin crosslinking.<br />
Marcos Garza-Madrid 1, 2 , J. Elisseeff 1 .<br />
1<br />
Translational Tissue Engineering Center, Wilmer<br />
Eye Institute, Johns Hopkins School of Medicine,<br />
Baltimore, MD; 2 Ophthalmology and Visual<br />
Sciences Research Chair, School of Medicine<br />
and Health Sciences, Tecnológico de Monterrey,<br />
Monterrey, Mexico *CR<br />
4075 — 10:00 Brillouin microscopy of<br />
collagen crosslinking: non-contact depthdependent<br />
analysis of corneal elastic modulus.<br />
Giuliano Scarcelli 1 , S. Kling 2 , E. Quijano 1 , R.<br />
Pineda 3 , S. Marcos 2 , S. H. Yun 1 . 1 Wellman Center<br />
for Photomedicine, Harvard Medical School,<br />
Cambridge, MA; 2 Instituto de Optica, Conjejo<br />
Superior de investigation cientifica, Madrid, Spain;<br />
3<br />
Ophthalmology, Mass eye and ear Infirmary,<br />
Boston, MA *CR<br />
TCC 304<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Visual Neuroscience<br />
412 Photoreceptors: Structure,<br />
Transduction, Signaling<br />
<strong>Wednesday</strong> Papers/<br />
Minisymposium<br />
8:30 am – 10:15 am<br />
Moderators: Joanne M. Wood and Heidi J. Hofer<br />
4063 — 8:30 Two-point detection and<br />
appearance in the absence of higher order<br />
aberrations. Heidi J. Hofer, D. E. Koenig. College<br />
of Optometry, University of Houston, Houston, TX<br />
4064 — 8:45 A Comparison of Acuity and<br />
Cone Density in the Temporal Retina. Nancy J.<br />
Coletta 1 , T. Y. Chui 2 , A. E. Elsner 2 . 1 Vision Science,<br />
New England College of Optometry, Boston,<br />
MA; 2 School of Optometry, Indiana University,<br />
Bloomington, IN *CR<br />
4065 — 9:00 Age-related variation in foveal,<br />
parafoveal and peripheral spatial suppression.<br />
Rigmor C. Baraas, C. Aaen-Stockdale, S. J. Gilson.<br />
Optometry & Visual Science, Buskerud University<br />
College, Kongsberg, Norway<br />
4066 — 9:15 Heterochromatic Modulation<br />
Photometry can be used to measure Macular<br />
Pigment Optical Density. Cord R. Huchzermeyer 1 ,<br />
J. Schlomberg 1 , U. Welge-Lüssen 1 , T. Berendschot 2 ,<br />
J. J. Kremers 1 . 1 Department of Ophthalmology,<br />
University Erlangen-Nuremberg, Erlangen,<br />
Germany; 2 University Eye Clinic, Maastricht,<br />
Netherlands<br />
4067 — 9:30 Comparability of Visual<br />
Performance of Individuals with Low Vision in<br />
Real and Virtual Street Intersections. Lei Liu,<br />
E. L. Bowman. School of Optometry, University of<br />
Alabama at Birmingham, Birmingham, AL<br />
4068 — 9:45 Optical quality and subjective<br />
judgments of blur under pure simultaneous<br />
vision. Carlos Dorronsoro, A. Radhakrishnan, L.<br />
Sawides, S. Marcos. Instituto de Optica, CSIC,<br />
Madrid, Spain *CR<br />
Moderators: Marie E. Burns and Wolfgang Baehr<br />
4076 — 8:30 Modulating the phototransduction<br />
cascade with small molecules. Tomoki Isayama 1 ,<br />
J. Wu 1 , S. Miyazono 1 , V. Lee 1 , E. S. Levine 1 , E.<br />
Makino 3 , A. L. Zimmerman 2 , C. L. Makino 1 .<br />
1<br />
Ophthalmology, Mass Eye & Ear Infirmary,<br />
Boston, MA; 2 Molecular Pharmacology, Physiology<br />
and Biotechnology, Brown University, Providence,<br />
RI; 3 LGCR, Sanofi Corporation, Waltham, MA<br />
4077 — 8:45 Under-expression of GAP<br />
proteins: Effect on Mouse Rod Response Decay.<br />
Gordon L. Fain 1, 2 , M. L. Woodruff 1 , C. J. Chen 3 .<br />
1<br />
Integrative Biology and Physiology, Univ of<br />
California-Los Angeles, Los Angeles, CA; 2 Jules<br />
Stein Eye Institute, UCLA, Los Angeles, CA;<br />
3<br />
Biochemistry and Molecular Biology, Virginia<br />
Commonwealth University, Richmond, VA<br />
4078 — 9:00 Light-induced translocation<br />
of RGS9-1 and Gβ5L in Mouse Rod<br />
Photoreceptors. You-Wei Peng 1 , M. Tian 1 , M. L.<br />
Zallocchi 1 , W. Wang 1 , C. J. Chen 2 , K. Palczewski 3 ,<br />
D. E. Cosgrove 1 . 1 Genetics, Boys Town Natl<br />
Research Hosp, Omaha, NE; 2 Biochemistry &<br />
Molecular Biology, Virginia Commonwealth<br />
University, Richmond, VA; 3 Pharmacology, Case<br />
Western Reserve University, Cleveland, OH *CR<br />
4079 — 9:15 Complete protein composition of<br />
the photoreceptor disc identified by label-free<br />
quantitative proteomics. Nikolai P. Skiba, V. Y.<br />
Arshavsky. Duke University, Durham, NC<br />
4080 — 9:30 Molecular Function of<br />
Peripherin-2/rds for Photoreceptor Membrane<br />
Structure. Andrew F. Goldberg, N. Khattree, L. M.<br />
Ritter. Eye Research Institute, Oakland University,<br />
Rochester Hills, MI<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
272
<strong>Wednesday</strong> – Papers/Minisymposium – 4081 – 4082<br />
4081 — 9:45 Bleach-Induced Desensitization<br />
and Response Compression of the Photocurrent<br />
and Photovoltage in Mouse Rods. Johan<br />
Pahlberg 1 , R. Frederiksen 2 , K. J. Miyagishima 1 , S.<br />
Nymark 2 , A. P. Sampath 1 , M. C. Cornwall 2 . 1 Zilkha<br />
Neurogenetic Institute, University of Southern<br />
California, Los Angeles, CA; 2 Boston University<br />
Medical School, Department of Physiology and<br />
Biophysics, Boston, MA<br />
4082 — 10:00 Phosphoinositides and<br />
membrane trafficking in zebrafish cone inner<br />
segments. Sara Hayden, S. E. Brockerhoff.<br />
Biochemistry, University of Washinton, Seattle, WA<br />
<strong>Wednesday</strong> Papers/<br />
Minisymposium<br />
8:30 am – 10:15 am<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
273
4083 – 4105 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
Exhibit Hall A0001-A0047<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Retina<br />
413 AMD II, RE<br />
Moderators: David R. Hinton and Diana V. Do<br />
4083 — A0001 Pars Plana Vitrectomy,<br />
Subretinal Injection of Recombinant Tissue<br />
Plasminogen Activator and Intraocular Gas<br />
Tamponade for Thick Submacular Hemorrhage<br />
with Polypoidal Choroidal Vasculopathy.<br />
Woohyok Chang, C. Cho, M. Sagong, H. Oh, J.<br />
Park, D. Park, M. Kim, W. Gu, J. Son. Department<br />
of Ophthalmology, Yeungnam Univ College of<br />
Medicine, Daegu, Republic of Korea<br />
4084 — A0002 The Effects of Docosahexaenoic<br />
Acid (DHA) Dietary Supplementation on Retinal<br />
Lipid Profile in a Mouse Model of Stargardt-like<br />
Macular Dystrophy (STGD3). Mandy Hong 1 , S.<br />
Kuny 1 , R. Bryant 1 , F. Gaillard 1 , M. Suh 2 , Y. Sauve 1 .<br />
1<br />
Ophthalmology, University of Alberta, Edmonton,<br />
AB, Canada; 2 Human Nutritional Sciences,<br />
University of Manitoba, Winnipeg, MB, Canada<br />
4085 — A0003 In vivo Evaluation of Surface<br />
Modified Expanded-polytetrafluroethylene<br />
(ePTFE) Substrate as a Permanent Substrate<br />
for Cell Transplantation. Shen Nian 1 , Z. Fu 1 , C.<br />
M. Sheridan 3 , V. Kearns 3 , R. Williams 3 , S. Wong 1 ,<br />
K. Vasilev 4 , A. Bachhuka 4 , A. C. Lo 1, 2 , W. W. Lai 1 .<br />
1<br />
Ophthalmology, University of Hong Kong, Hong<br />
Kong, Hong Kong; 2 Research Centre of Heart,<br />
Brain, Hormone and Healthy Aging, University of<br />
Hong Kong, Hong Kong, Hong Kong; 3 Eye and<br />
Vision Science, University of Liverpool, Liverpool,<br />
United Kingdom; 4 Mawson Institute and School<br />
of Advanced Manufacturing, University of South<br />
Australia, Mawson Lakes, SA, Australia<br />
4086 — A0004 Prevalence of Subretinal<br />
Drusenoid Deposits in Age-Related Macular<br />
Degeneration with Newly Diagnosed Choroidal<br />
Neovascularization. Sandrine A. Zweifel, R. A.<br />
Rieder, M. M. Kohler, R. Gambon. Department of<br />
Ophthalmology, University Hospital Zurich, Zurich,<br />
Switzerland<br />
4087 — A0005 Autofluorescence and OCT of<br />
Retinal pigment epithelial tears. Naoto Hanyuda,<br />
T. Sato, R. Mukai, S. Kishi. Gunma University,<br />
Maebashi, Japan *CR<br />
4088 — A0006 Anatomic patterns and clinical<br />
presentation of recurrence in ‘stable’ wet Age<br />
Related Macular Degeneration (AMD) patients.<br />
Fani Zacharaki, M. N. Chandran, N. Nair, P.<br />
Vijayakumar, G. Menon. Frimley Park Hospital<br />
NHS Foundation Trust, Frimley, United Kingdom<br />
*CR<br />
4089 — A0007 Detection and Quantification<br />
of Autofluorescence Abnormalities in Patients<br />
with Neovascular Macular Degeneration using<br />
a Fully Automated Image Analysis Algorithm.<br />
Kathryn L. Pepple, Q. Nie, S. S. Ong, S. W. Cousins.<br />
Ophthalmology, Duke Eye Center, Durham, NC<br />
*CR<br />
4090 — A0008 Ranibizumab Leads to<br />
Regression or Elimination of Choroidal<br />
Neovascular Membranes in Most Eyes with<br />
AMD: A HARBOR Subanalysis. Nikolas J.<br />
London 1 , P. E. Tornambe 1 , L. Yau 2 , J. A. Nau 2 , L.<br />
Tuomi 2 . 1 Retina Consultants San Diego, San Diego,<br />
CA; 2 Genentech Inc., South San Francisco, CA<br />
*CR, f<br />
4091 — A0009 Anti-VEGF Gene Therapy for<br />
Wet AMD: Phase I/II Safety and Pharmacology<br />
Results. Elizabeth P. Rakoczy 1, 2 , M. Lai 1, 2 ,<br />
C. Pierce 2 , A. L. Magno 2 , R. Samulski 3 , T. W.<br />
Chalberg 4 , M. S. Blumenkranz 5 , I. Constable 1, 2 .<br />
1<br />
Centre for Ophthalmology and Visual Sciences,<br />
The University of Western Australia, Perth, WA,<br />
Australia; 2 Molecular Ophthalmology, Lions Eye<br />
Institute, Perth, WA, Australia; 3 Gene Therapy<br />
Centre, University of North Carolina, Chapel Hill,<br />
NC; 4 Avalanche Biotechnologies, San Francisco,<br />
CA; 5 Byers Eye Institute at Stanford, Palo Alto, CA<br />
*CR, f<br />
4092 — A0010 Polypoidal choroidal<br />
vasculopathy in Caucasian patients. Stephen<br />
Davis, A. Lauer, C. J. Flaxel. Oregon Health and<br />
Science University, Casey Eye Institute, Portland,<br />
OR *CR<br />
4093 — A0011 Baseline characteristics and<br />
response to intravitreal ranibizumab therapy for<br />
age-related macular degeneration. Misa Suzuki,<br />
N. Nagai, K. Izumi-Nagai, H. Shinoda, T. Koto,<br />
A. Uchida, H. Mochimaru, K. Yuki, K. Tsubota, Y.<br />
Ozawa. Ophthalmology, Keio University School of<br />
Medicine, Tokyo, Japan *CR, f<br />
4094 — A0012 Disease Activity in Disciform<br />
Scars due to Age-Related Macular Degeneration<br />
(AMD). Deborah Witkin 1 , J. B. Sanderson 1 , D.<br />
Ferrara 2, 1 , E. Reichel 1 . 1 Ophthalmology, Tufts<br />
Medical Center, Boston, MA; 2 Digital Angiography<br />
Reading Center DARC, Great Neck, NY *CR<br />
4095 — A0013 The Incidence of Neovascular<br />
Subtypes in Newly Diagnosed Wet Age-Related<br />
Macular Degeneration. Jesse J. Jung 1, 3 , L.<br />
Xu 2, 5 , R. Gallego-Pinazo 2, 4 , S. Mrejen 2, 3 , M.<br />
Marsiglia 2, 3 , S. Boddu 1 , K. Freund 1, 2 . 1 Department<br />
of Ophthalmology, New York Univ School of<br />
Med, New York, NY; 2 Vitreous Retina Macula<br />
Consultants of New York, New York, NY; 3 LuEsther<br />
T. Mertz Retinal Research Center, Manhattan<br />
Eye, Ear, and Throat Hospital, New York, NY;<br />
4<br />
Department of Ophthalmology, University and<br />
Polytechnic Hospital La Fe, Valencia, Spain; 5 St.<br />
Vincent’s Medical Center, Bridgeport, CT *CR<br />
4096 — A0014 Choroidal thickness change<br />
following intravitreal bevacizumab therapy<br />
for wet age-related macular degeneration: Six<br />
months results. Sharif Y. El Emam, G. Barteselli, J.<br />
Chhablani, S. Lee, I. Kozak, L. Cheng, W. Freeman.<br />
Ophthalmology, Shiley Eye Center, UCSD, La<br />
Jolla, CA *CR<br />
4097 — A0015 The Relationship of Choroidal<br />
Thickness to Scotopic Sensitivity in Agerelated<br />
Macular Degeneration (AMD). Karl G.<br />
Csaky 1, 3 , D. G. Birch 1, 2 , R. Gelman 1 , J. Felius 1 .<br />
1<br />
Ophthalmology, Retina Foundation of the<br />
Southwest, Dallas, TX; 2 Ophthalmology, University<br />
of Texas Southwestern Medical Center, Dallas, TX;<br />
3<br />
Texas Retina Associates, Dallas, TX *CR<br />
4098 — A0016 Choroidal Thickness<br />
following Anti-Vascular Endothelial Growth<br />
Factor Therapy for Neovascular Age-Related<br />
Macular Degeneration. Charlotte So, Z. Ravage.<br />
Ophthalmology, Rush University Medical Center,<br />
Chicago, IL<br />
4099 — A0017 Correlation Between Changes<br />
in Subfoveal Choroidal Thickness and 1-Year<br />
Outcomes of Ranibizumab Therapy for<br />
Polypoidal Choroidal Vasculopathy. Taiichi<br />
Hikichi, H. Kitamei, S. Shioya, M. Higuchi, T.<br />
Matsushita, S. Kosaka, R. Matsushita, K. Takami,<br />
H. Ohtsuka. Ohtsuka Eye Hospital, Sapporo, Japan<br />
4100 — A0018 Axial Length and Subfoveal<br />
Choroidal Thickness in Individuals with Agerelated<br />
Macular Degeneration (AMD). Chih<br />
Ping Wang 1, 2 , C. Lai 1, 2 , J. Huang 1, 2 , C. Kuo 1, 2 .<br />
1<br />
Department of Ophthalmology, Chang Gung<br />
Memorial Hospital, Chiayi, Chiayi County, Taiwan;<br />
2<br />
Chang Gung University, Taoyan, Taiwan<br />
4101 — A0019 APE1/Ref-1 redox inhibitor<br />
APX3330 modulates choroidal endothelial cells<br />
by transcriptional regulation of NF-κB and<br />
STAT3 activity. Xiaoxi Qiao 1 , Y. Li 1 , X. Liu 1 , T.<br />
Zhou 1 , M. R. Kelley 2 , P. A. Edwards 1 , H. Gao 1 .<br />
1<br />
Ophthalmology, Henry Ford Health System,<br />
Detroit, MI; 2 Herman B Wells Center for Pediatric<br />
Research, Indiana University School of Medicine,<br />
Indianapolis, IN *CR<br />
4102 — A0020 Apolipoprotein mimetic Dual<br />
Domain Peptide reduces Neutral Lipid Deposits<br />
in murine Bruch’s Membrane. Armin Mohi, S.<br />
Grisanti, M. Rudolf. Department of Ophthalmology,<br />
University of Luebeck, Luebeck, Germany *CR<br />
4103 — A0021 Identification of Human<br />
Macular Tissue Antigens Recognized by Serum<br />
Auto-Antibodies (auto-Abs) in Patients with<br />
Age-Related Macular Degeneration (AMD).<br />
Nataliya I. Lenchik 1, 2 , F. Giorgianni 3 , S. Beranova-<br />
Giorgianni 3 , I. C. Gerling 1 , M. Z. Radic 4 , A.<br />
Iannaccone 2 . 1 Medicine/Endocrinology, Univ.<br />
Tennessee HSC, Memphis, TN; 2 Hamilton Eye<br />
Institute, Univ. Tennessee HSC, Memphis, TN;<br />
3<br />
Pharmaceutical Sciences, Univ. Tennessee HSC,<br />
Memphis, TN; 4 Microbiology, Immunology &<br />
Biochemistry, Univ. Tennessee HSC, Memphis, TN<br />
4104 — A0022 Early ocular lipid deposition<br />
in a mouse model of hyperlipidemia and<br />
atherosclerosis. Michaela K. Mathews, T. Albukh,<br />
K. E. Duncan. Ophthalmology, Univ of Maryland,<br />
Baltimore, Baltimore, MD<br />
4105 — A0023 The role of systemic infection<br />
and response to Ranibizumab therapy for Age<br />
Related Macular Degeneration (AMD). Charles<br />
O. Pierce 1, 2 , M. Nelson 2 , J. Scott 1 , H. L. Griffiths 1 ,<br />
N. L. James 1 , H. A. Thomson 1 , A. J. Cree 1 , A. J.<br />
Lotery 1, 2 . 1 Clinical Neurosciences, University of<br />
Southampton, Southampton, United Kingdom;<br />
2<br />
University Hospital of Southampton, Southampton,<br />
United Kingdom *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
274
<strong>Wednesday</strong> – Posters – 4106 – 4129<br />
4106 — A0024 Immunohistochemical analysis<br />
of primate drusen reveals homologous protein<br />
expression between monkey and human.<br />
Trevor J. McGill 1 , L. Renner 2 , A. R. Weiss 2 , K. D.<br />
Rittenhouse 3 , J. Lee 2 , J. Fruebis 3 , M. Sperling 3 , M.<br />
Neuringer 2 . 1 Ophthalmology, Casey Eye Institute-<br />
OHSU, Portland, OR; 2 Neuroscience, Oregon<br />
National Primate Research Center, Beaverton, OR;<br />
3<br />
Ophthalmology External Research Unit, Pfizer,<br />
Cambridge, MA *CR<br />
4107 — A0025 A Pathway-based Genome-wide<br />
Analysis Yields Multi-locus AMD Associations in<br />
Genes Encoding JNK/MAPK Pathway Elements,<br />
Platelet Activation Triggers, and Targets of<br />
miR34 and HDAC1. John Paul P. SanGiovanni.<br />
Clinical Trials Branch, National Eye Institute/NIH,<br />
Bethesda, MD<br />
4108 — A0026 Minocycline protects retinal<br />
pigment epithelial cells from hypoxia. Joanna<br />
DaCosta. Cranfield Health, Cranfield University,<br />
Cranfield, United Kingdom<br />
4109 — A0027 Dominantly Inherited Early<br />
Onset Maculopathy in Japanese Macaques:<br />
Drusen Progression. Anda Cornea 1 , L. Renner 1 ,<br />
S. Hurst 1 , T. J. McGill 2 , M. E. Pennesi 2 , K. D.<br />
Rittenhouse 3 , M. Sperling 3 , J. Fruebis 3 , M.<br />
Neuringer 1, 2 . 1 Oregon National Primate Research<br />
Center, Oregon Health & Science University,<br />
Beaverton, OR; 2 Casey Eye Institute, Oregon<br />
Health & Science University, Portland, OR;<br />
3<br />
Ophthalmology External Research Unit, Pfizer,<br />
Cambridge, MA *CR<br />
4110 — A0028 Progression of Atrophic<br />
Macular Degeneration in Rhesus Monkeys<br />
Deficient in Lutein/Zeaxanthin and Omega-3<br />
Fatty Acids. Laurie Renner 1 , S. Hurst 1 , T. J.<br />
McGill 2 , A. R. Weiss 1 , T. Stout 2 , D. J. Wilson 2 , M.<br />
Neuringer 1, 2 . 1 Oregon National Primate Research<br />
Center, Oregon Health & Science University,<br />
Beaverton, OR; 2 Casey Eye Institute, Oregon Health<br />
& Science University, Portland, OR *CR<br />
4111 — A0029 Biocompatible injectable<br />
hydrogel to extend the release of intravitreal<br />
drugs. Thomas R. Friberg 1, 2 , B. M. Rauck 2 , C.<br />
A. Medina-Mendez 1 , Y. Wang 2 . 1 Ophthalmology/<br />
UPMC Eye Center, Univ of Pittsburgh, Pittsburgh,<br />
PA; 2 Bioengineering, University of Pittsburgh,<br />
Pittsburgh, PA *CR<br />
4112 — A0030 Effect of Repeated Delivery<br />
of Neural Progenitors on Vision Preservation<br />
in RCS Rats. Bin Lu 1 , Y. Tsai 1 , G. Adamus 2 , S.<br />
Girman 1 , L. Shen 1 , D. M. Gamm 3 , C. W. Morgans 2 ,<br />
B. Shelley 1 , C. Svendsen 1 , S. Wang 1 . 1 Regenerative<br />
Medicine Institute, Cedars Sinai Medical Center,<br />
Los Angeles, CA; 2 Casey Eye Institute, Oregon<br />
Health & Science University, Portland, OR;<br />
3<br />
Department of Ophthalmology, University of<br />
Wisconsin, Madison, WI *CR<br />
4113 — A0031 Comparison of intravitreally<br />
injected ranibizumab versus aflibercept in the<br />
retina and choroid of the primate eye. Sylvie<br />
Julien, U. Schraermeyer. Experimental Vitreoretinal<br />
Surgery, Centre for Ophthalmology, Tuebingen,<br />
Germany *CR<br />
4114 — A0032 Metabolomic profiles distinguish<br />
Age-related Macular Degeneration patients.<br />
Samantha Williamson 1 , Y. Park 3 , K. Uppal 3 , V.<br />
Tran 3 , J. McGrath 2 , A. Agarwal 1 , M. A. Pericak-<br />
Vance 4 , J. L. Haines 2 , D. P. Jones 3 , M. A. Brantley 1 .<br />
1<br />
Vanderbilt Eye Institute, Vanderbilt University,<br />
Nashville, TN; 2 Center for Human Genetics<br />
Research, Vanderbilt University, Nashville, TN;<br />
3<br />
Department of Medicine, Emory University,<br />
Atlanta, GA; 4 Hussman Institute of Human<br />
Genomics, Miller School of Medicine, University of<br />
Miami, Miami, FL *CR<br />
4115 — A0033 Metabolites that discriminate<br />
between neovascular AMD and control patients<br />
associate with different ARMS2 genotypes.<br />
Megan B. Parks 1 , Y. Park 2 , L. Burgess 1 , K. Lee 3 ,<br />
P. Sternberg 1 , D. P. Jones 2 , M. A. Brantley 1 .<br />
1<br />
Vanderbilt Eye Institute, Vanderbilt University,<br />
Nashville, TN; 2 Department of Medicine, Emory<br />
University, Atlanta, GA; 3 Department of Industrial<br />
Engineering, Hanyang University, Seoul, Republic<br />
of Korea<br />
4116 — A0034 The Composition of the<br />
Vitreous Proteome in Patients with Wet AMD<br />
Can Differentiate Between CNV and RAP: An<br />
Important New Diagnostic Tool. Stephanie M.<br />
Ecker, J. C. Hines, A. O. Igbre, B. M. Glaser. Ocular<br />
Proteomics, National Retina Institute, Towson, MD<br />
*CR<br />
4117 — A0035 Metabolic pathways associated<br />
with Age-related Macular Degeneration (AMD).<br />
L. Goodwin Burgess 1 , Y. Park 2 , M. B. Parks 1 , K.<br />
Lee 3 , P. Sternberg 1 , D. P. Jones 2 , M. A. Brantley 1 .<br />
1<br />
Vanderbilt Eye Institute, Vanderbilt University,<br />
Nashville, TN; 2 Department of Medicine, Emory<br />
University, Atlanta, GA; 3 Department of Industrial<br />
Engineering, Hanyang University, Seoul, Republic<br />
of Korea<br />
4118 — A0036 Age-related macular<br />
degeneration and complement C3 in liver<br />
transplant patients. Samir Khandhadia 1, 2 , S.<br />
Hakobyan 3 , A. J. Cree 1 , A. J. Lotery 1, 2 . 1 Clinical and<br />
Experimental Sciences, Clinical Neurosciences,<br />
University of Southampton, Southampton,<br />
United Kingdom; 2 Eye Unit, University Hospital<br />
Southampton NHS Foundation Trust, Southampton,<br />
United Kingdom; 3 School of Medicine, Cardiff<br />
University, Cardiff, United Kingdom *CR<br />
4119 — A0037 Ophthalmologic exam in Age<br />
Macular Degeneration-Alzheimer Disease:<br />
its interest in detection, follow-up of AMD, of<br />
Alzheimer disease, its relevance to highlight<br />
the links and correlations between AMD and<br />
AD. Corinne Gonzalez. Ophthalmology, Cabinet<br />
Medical, Toulouse, France<br />
4120 — A0038 Variants in the VEGFA gene and<br />
visual outcome after anti-VEGF treatment for<br />
neovascular age-related macular degeneration.<br />
Manuel M. Hermann 1 , P. S. Muether 1 , D.<br />
Smailhodzic 2 , A. I. Den Hollander 2 , B. Kirchhof 1 , S.<br />
Fauser 1 . 1 Department of Ophthalmology, University<br />
Hospital of Cologne, Koeln, Germany; 2 Department<br />
of Ophthalmology, Radboud University Nijmegen<br />
Medical Center, Nijmegen, Netherlands *CR, f<br />
4121 — A0039 Level of vascular endothelial<br />
growth factor 165b in human aqueous humor.<br />
Takayuki Baba, G. Bikbova, M. Kitahashi, H.<br />
Yokouchi, M. Sakurai, M. Kubota-Taniai, S.<br />
Yamamoto. Ophthalmology & Visual Science, Chiba<br />
Univ Grad School of Med, Chiba, Japan<br />
4122 — A0040 Plasma levels of vascular<br />
endothelial growth factor and anti-vascular<br />
endothelial growth factor before and after<br />
intravitreal injection of anti-vascular endothelial<br />
growth factor. Sang Jun Park, M. Yoon, A.<br />
Chung, H. Chin. Department of Ophthalmology,<br />
Inha Vision Science Laboratory, Inha University<br />
School of Medicine, Incheon, Democratic People’s<br />
Republic of Korea<br />
4123 — A0041 Quercetin Protects Hydrogen<br />
Peroxide Damaged Human Retinal Pigment<br />
Epithelial (hRPE) Cells and Inhibits Vascular<br />
Endothelial Growth Factor (VEGF) Production.<br />
Andrew Kumar 1, 2 , P. C. Kothary 2 , M. A. Del Monte 2 .<br />
1<br />
Wayne State University, Detroit, MI; 2 Department<br />
of Ophthalmology and Visual Science, University of<br />
Michigan, Ann Arbor, MI<br />
4124 — A0042 Lutein supplementation leads<br />
to a decreased level of circulating complement<br />
factors. Tos TJM Berendschot 1 , Y. Tian 1 , I. J.<br />
Murray 2 , M. Makridaki 2 , R. van der Veen 1 , A.<br />
Kijlstra 1 . 1 University Eye Clinic Maastricht,<br />
Maastricht, Netherlands; 2 Faculty of Life Sciences,<br />
University of Manchester, Manchester, United<br />
Kingdom f<br />
4125 — A0043 Hyperhomocysteinemia as a risk<br />
factor of polypoidal choroidal vasculopathy. Hui-<br />
Chen Cheng 1, 2 , P. Lin 1, 2 . 1 Ophthalmology, School of<br />
Medicine, National Yang-Ming University, Taipei,<br />
Taiwan; 2 Ophthalmology, Taipei Veterans General<br />
Hospital, Taipei, Taiwan<br />
4126 — A0044 Influence of bevacizumab<br />
on Platelet activation profile in vitro. Bianka<br />
Sobolewska 1 , F. Ziemssen, C. Grimmel 2 , J.<br />
Kwiatkowska 3 , M. S. Spitzer 1 , M. Gawaz 3 ,<br />
T. Biedermann 2 , K. Stellos 3 . 1 Centre for<br />
Ophthalmology, University of Tuebingen,<br />
Tuebingen, Germany; 2 Dermatology, University of<br />
Tuebigen, Tuebingen, Germany; 3 Cardiology and<br />
Cardiovascular Medicine, University of Tuebigen,<br />
Tuebingen, Germany *CR<br />
4127 — A0045 Effects of Plasma Kallikrein on<br />
the neuroretina in diabetic rats. Gongxiong Wu,<br />
E. P. Feener. Vascular Cell Biology, Joslin Diabetes<br />
Center, Boston, MA *CR<br />
4128 — A0046 Choroidal Neovascularization<br />
Response of New Zealand White Rabbits and<br />
Dutch Belt Pigmented Animals to Sustained<br />
Simultaneous Release of both VEGF and bFGF<br />
within the Suprachoroidal Space. Corinne<br />
G. Wong. Ophthalmic Drug Dev, Sclera LLC,<br />
Carlsbad, CA<br />
4129 — A0047 Associations of IL-10 with<br />
Choroidal Neovascularization in high myopia.<br />
Yukimi Yamamoto 1 , D. Miyazaki 1 , S. Sasaki 2 , K.<br />
Miyake 1 , S. Kaneda 1 , Y. Ikeda 1 , A. Yamasaki 1 , Y.<br />
Inoue 1 . 1 Tottori University, Yonago, Japan; 2 Okihospital,<br />
Oki District, Japan<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
275
4130 – 4149 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
Exhibit Hall A0048-A0094<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Retina<br />
414 AMD III, RE<br />
Moderators: Itay Chowers and Christine A. Curcio<br />
4130 — A0048 Focal Retinal Sensitivity Before<br />
and After Selective Retina Therapy for Central<br />
Serous Chorioretinopathy. Ayako Yasui 1 , M.<br />
Yamamoto 1 , T. Kohno 1 , T. yoneda 1 , Y. Yoshida 1 ,<br />
H. Iwami 1 , D. Theisen-Kunde 2 , Y. Miura 2, 3 , R.<br />
Brinkmann 2 , K. Shiraki 1 . 1 Ophthalmology and<br />
Visual Science, Osaka city University, Osaka,<br />
Japan; 2 Medical Laser Center Luebeck, Luebeck,<br />
Germany; 3 Institute of Biomedical Optics,<br />
University of Luebeck, Luebeck, Germany *CR, f<br />
4131 — A0049 Automatic Temperature<br />
Controlled Retinal Photocoagulation Facilitates<br />
Four Predictable Lesion Strengths Including<br />
Sub-threshold Lesions. Stefan O. Koinzer 1 ,<br />
C. Hesse 1 , A. Baade 2 , K. Schlott 3, 2 , A. Caliebe 4 ,<br />
M. Saeger 1 , R. Brinkmann 3, 2 , J. Roider 1 .<br />
1<br />
Ophthalmology Campus Kiel, University hospital<br />
of Schleswig-Holstein, Kiel, Germany; 2 Medical<br />
Laser Center Luebeck GmbH, Luebeck, Germany;<br />
3<br />
Institute of Biomedical Optics, University of<br />
Luebeck, Luebeck, Germany; 4 Institute of Medical<br />
Informatics and Statistics, University hospital of<br />
Schleswig-Holstein, Kiel, Germany *CR<br />
4132 — A0050 Modulation of Transgene<br />
Expression in Retinal Gene Therapy by<br />
Selective Laser Treatment. Daniel Lavinsky 2, 1 ,<br />
T. W. Chalberg 3 , Y. Mandel 2 , P. Huie 2 , R. Dalal 2 ,<br />
M. F. Marmor 2 , D. V. Palanker 2 . 1 Ophthalmology,<br />
Federal Univesity of Rio Grande do Sul, Porto<br />
Alegre, Brazil; 2 Ophthalmology and HEPL,<br />
Stanford University, Stanford, CA; 3 Avalanche<br />
Biotechnologies, San Francisco, CA *CR<br />
4133 — A0051 Fluorescein angiography<br />
versus superimposed OCT-guided macular laser<br />
photocoagulation. Igor Kozak 1, 2 , S. El-Emam 1 , L.<br />
Cheng 1 , D. G. Bartsch 1 , J. Chhablani 3 , W. Freeman 1 ,<br />
N. G. Ghazi 2 , J. Arevalo 2, 4 . 1 Ophthalmology,<br />
University of California San Diego, La Jolla, CA;<br />
2<br />
Vitreoretinal Division, King Khaled Eye Specialist<br />
Hospital, Riyadh, Saudi Arabia; 3 Vitreoretina, LV<br />
Prasad Eye Institute, Heyderabad, India; 4 Wilmer<br />
Eye Institute, Johns Hopkins University, Baltimore,<br />
MD *CR<br />
4134 — A0052 Six-month Report of<br />
Selective Retina Therapy on Central Serous<br />
Chorioretinopathy in Japanese Patients. Manabu<br />
Yamamoto 1 , T. Kohno 1 , T. Voneda 1 , Y. Yoshida 1 , H.<br />
Iwami 1 , A. Yasui 1 , D. Theisen-Kunde 2 , Y. Miura 3 ,<br />
R. Brinkmann 3, 2 , K. Shiraki 1 . 1 Ophthalmology &<br />
Visual Sciences, Osaka City Univ Grad School<br />
of Medicine, Osaka-Shi, Japan; 2 Medical Laser<br />
Center Luebeck, Luebeck, Germany; 3 Institute<br />
of Biomedical Optics, University of Luebeck,<br />
Luebeck, Germany *CR, f<br />
4135 — A0053 Approach to Previously<br />
Vitrectomized Patients with Neovascular Age-<br />
Related Macular Degeneration with Reduced<br />
Response to Anti-vascular Endothelial Growth<br />
Factor Treatment. Mohammad Zubair Y.<br />
Arain 1 , Q. V. Hoang 1, 2 , J. S. Slakter 2 , S. Chang 1 .<br />
1<br />
Ophthalmology, Edward S. Harkness Eye Institute,<br />
Columbia University Medical Center, New York,<br />
NY; 2 Vitreous, Retina, Macula Consultants of New<br />
York, New York, NY *CR<br />
4136 — A0054 Selective retina treatment<br />
(SRT) automatically controlled by a real-time<br />
reflectometry in a rabbit model. Young Jung<br />
Roh 1 , E. Seifert 2 , T. Dirk 2 , Y. Park 1 , S. Kang 1 , R.<br />
Brinkmann 2 . 1 Ophthalmology, St Mary’s Hospital,<br />
Seoul, Republic of Korea; 2 Biomedical Optics,<br />
University of Lubeck, Lubeck, Germany *CR<br />
4137 — A0055 Effects of repeated subthreshold<br />
micropulse laser photocoagulation in rabbit<br />
eyes. Dongkyu Lee 1 , H. Kang 1 , S. Lee 2 , Y. You 1 , S.<br />
Kim 1 , O. Kwon 1 . 1 Retina center, Nune Eye Hospital,<br />
Seoul, Republic of Korea; 2 Ophthalmology,<br />
Soonchunhynag University Hospital, Seoul,<br />
Republic of Korea<br />
4138 — A0056 Classification of Rabbit<br />
Photocoagulation Lesions in Optical Coherence<br />
Tomography and Class-related Coagulation<br />
Temperatures. Carola Hesse 1 , S. O. Koinzer 1 , A.<br />
Baade 2 , K. Schlott 2, 3 , A. Caliebe 4 , M. Saeger 1 , R.<br />
Brinkmann 3, 2 , J. Roider 1 . 1 Dept. of Ophthalmology,<br />
Campus Kiel, University Hospital of Schleswig-<br />
Holstein, Kiel, Germany; 2 Medical Lasercenter<br />
Lübeck GmbH, Lübeck, Germany; 3 Institut of<br />
Biomedical Optics, University of Lübeck, Lübeck,<br />
Germany; 4 Institut of Medical Informatics and<br />
Statistics, University Hospital of Schleswig-<br />
Holstein, Kiel, Germany *CR<br />
4139 — A0057 Various Laser Treatments for<br />
Retinal Capillary Hemangioma. Liqin Gao, F.<br />
Zhang. Department of Ophthalmology, Beijing<br />
Tongren Hospital, Beijing, China<br />
4140 — A0058 Subthreshold diode micropulse<br />
laser photocoagulation versus low-fluence<br />
photodynamic therapy for the treatment of<br />
chronic central serous chorioretinopathy.<br />
Juan Giralt 1 , R. P. Casaroli-Marano 1 , A. Burés-<br />
Jelstrup 2 , R. Navarro 2 , J. Martinez-Toldos 3 , C.<br />
Fernandez-Martinez 3 , M. Alforja 1 , A. Rey Torrente 1 .<br />
1<br />
Ophthalmology, Hospital Clinic de Barcelona,<br />
Barcelona, Spain; 2 IMO, Barcelona, Spain;<br />
3<br />
Hospital General Universitario de Elche, Elche,<br />
Spain *CR<br />
4141 — A0059 Early changes on SD-OCT<br />
in eyes with cystoid macular edema (CME)<br />
after 577 nm subthreshold MicroPulse Laser<br />
Treatment (MPLT). Paola Salvetti 1 , L. de Polo 1, 2 ,<br />
M. Oldani 1, 2 , R. Ruello 1 . 1 Centro Oculistico<br />
Bergamasco, Bergamo, Italy; 2 Eye Clinic<br />
Department of Biomedical and Clinical Science<br />
“Luigi Sacco”, Luigi Sacco Hospital, Milano, Italy<br />
4142 — A0060 Threshold and Subthreshold<br />
Retinal Laser Therapy. But which Threshold?<br />
Giorgio Dorin. Clinical Application Development,<br />
IRIDEX Corp, Mountain View, CA *CR<br />
4143 — A0061 Persistence of Weekly Vision<br />
Self-monitoring Behavior in Non-Neovascular<br />
Age-Related Macular Degeneration Subjects<br />
Randomized to the Vision and Memory<br />
Stimulating (VMS) booklet. Mark C. Roser 1 , P.<br />
Beaton 1 , S. Torr-Brown 1 , A. Nwanko 2 , G. Dagnelie 2 ,<br />
A. K. Bittner 2 . 1 Results Group, LLC, Hebron, CT;<br />
2<br />
1Johns Hopkins Wilmer Eye Institute, Baltimore,<br />
MD *CR, f<br />
4144 — A0062 Screening for AMD at an<br />
University Hospital: Database análisis and<br />
considerations. Carmen N. Demetrio, M. Zas.<br />
Ophthalmology, Hospital de Clínicas, Buenos Aires,<br />
Argentina<br />
4145 — A0063 Zinc supplementation lowers<br />
complement overactivation in patients with<br />
age-related macular degeneration. B. Jeroen<br />
Klevering 1 , D. Smailhodzic 1 , A. I. Den Hollander 1, 2 ,<br />
J. P. van de Ven 1 , J. M. Groenewoud 3 , S. Fauser 4 ,<br />
M. R. Daha 5 , G. van der Wilt 3 , C. B. Hoyng 1 .<br />
1<br />
Ophthalmology, Radboud University Nijmegen<br />
Medical Centre, Nijmegen, Netherlands;<br />
2<br />
Department of Human Genetics, Radboud<br />
University Nijmegen Medical Centre, Nijmegen,<br />
Netherlands; 3 Department of Epidemiology,<br />
Biostatistics, and HTA, Radboud University<br />
Nijmegen Medical Centre, Nijmegen, Netherlands;<br />
4<br />
Ophthalmology, University of Cologne, Cologne,<br />
Germany; 5 Department of Nephrology, Leiden<br />
University Medical Center, Leiden, Netherlands f<br />
4146 — A0064 Novel Laser treatment for<br />
Early Age-related Macular Degeneration. Kate<br />
Brassington 1 , L. Gurrin 3 , K. Aung 1 , R. H. Guymer 1, 2 .<br />
1<br />
Centre for Eye Research Australia, Royal Victorian<br />
Eye and Ear Hospital, Melbourne, VIC, Australia;<br />
2<br />
Department of Ophthalmology, University of<br />
Melbourne, Melbourne, VIC, Australia; 3 Melbourne<br />
School of Population Health, University of<br />
Melbourne, Melbourne, VIC, Australia *CR, f<br />
4147 — A0065 ex vivo Spectral Domain<br />
Optical Coherence Tomography (SD-OCT)<br />
of Retina-Choriocapillaris (R-CC) Specimen:<br />
Factors influencing Image Quality. Laurenz L.<br />
Sonnentag, S. Grisanti, M. Rudolf. Department of<br />
Ophthalmology, University of Luebeck, Luebeck,<br />
Germany *CR<br />
4148 — A0066 Quantitative Optical Coherence<br />
Tomography Analysis Of Change in Pigment<br />
Epithelial Detachment Morphology Following<br />
Intravitreal Aflibercept Injection In Eyes With<br />
Recalcitrant Neovascular Age-Related Macular<br />
Degeneration. Mihai Mititelu, D. S. Grewal,<br />
D. Sarezky, R. Mirza, M. K. Gill, A. T. Lyon.<br />
Ophthalmology, Northwestern University, Feinberg<br />
School of Medicine, Chicago, IL<br />
4149 — A0067 Drusen Detection on<br />
Multimodal Imaging- Early Markers<br />
Observational Study. Rufino Silva 1, 2 , R. E. Hogg 3 ,<br />
G. Murphy 3 , G. Staurenghi 4 , C. Rosina 4 , A. Santos 2 ,<br />
U. Chakravarthy 3 . 1 Ophthalmology, Universitary<br />
Hospital Coimbra Center, Coimbra, Portugal; 2 CEC,<br />
AIBILI, Coimbra, Portugal; 3 Center for Vision<br />
and Vascular Science, Queen’s University Belfast,<br />
Belfast, Ireland; 4 Dept of Biomedical and Clinical<br />
Science (Luigi Sacco), University of Milan, Milan,<br />
Italy *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
276
<strong>Wednesday</strong> – Posters – 4150 – 4169<br />
4150 — A0068 Automated prediction of AMD<br />
progression from quantified SD-OCT images.<br />
Theodore Leng 1 , L. de Sisternes 2 , Q. Chen 2, 3 , J. Ma 1 ,<br />
V. Mahendra 1 , D. Rubin 2 . 1 Ophthalmology, Byers<br />
Eye Institute at Stanford, Palo Alto, CA; 2 Radiology<br />
and Medicine (Biomedical Informatics Research),<br />
Stanford University School of Medicine, Stanford,<br />
CA; 3 School of Computer Science and Engineering,<br />
Nanjing University of Science and Technology,<br />
Nanjing, China *CR<br />
4157 — A0075 The Dynamics of<br />
Hyperreflectant Central Target Lesions<br />
In Reticular Macular Disease (RMD) In<br />
Age-related Macular Degeneration (AMD).<br />
Nicole M. Pumariega 1 , R. M. Cymerman 1 , B.<br />
Butler 1 , N. Massamba 2 , E. H. Souied 2 , R. Smith 1 .<br />
1<br />
Ophthalmology, New York University Medical<br />
Center, College of Medicine, New York, NY;<br />
2<br />
Retina Creteil, Creteil Eye Clinic Univ Hospital,<br />
Créteil, France *CR<br />
4163 — A0081 Dark Adaptometry As a<br />
Functional Outcome Measure in Age-Related<br />
Macular Degeneration. E Lauren Doss 1, 2 , T.<br />
Glaser 1, 2 , E. Agrón 2 , D. L. Nigam 2 , W. T. Wong 3 ,<br />
E. Y. Chew 2 , C. A. Cukras 2 . 1 School of Medicine,<br />
University of California-San Francisco, San<br />
Francisco, CA; 2 National Eye Insititute, National<br />
Institutes of Health (NIH), Bethesda, MD; 3 Office<br />
of the Scientific Director, National Eye Institute,<br />
National Institutes of Health (NIH), Bethesda, MD<br />
4164 — A0082 Diagnostic accuracy of<br />
multifocal pupillographic objective perimetry in<br />
early age-related macular degeneration. Faran<br />
Sabeti 1, 2 , A. Saikal 1, 2 , M. Kolic 1, 2 , C. F. Carle 1, 2 ,<br />
R. W. Essex 3 , A. C. James 1, 2 , T. Maddess 1, 2 . 1 Eccles<br />
Institute of Neuroscience, Australian National<br />
University, Canberra, ACT, Australia; 2 ARC<br />
Centre of Excellence in Vision Science, Canberra,<br />
ACT, Australia; 3 Ophthalmology Department, The<br />
Canberra Hospital, Canberra, ACT, Australia *CR<br />
4151 — A0069 Significance of Drusen<br />
Regression in Intermediate Age-Related Macular<br />
Degeneration (AMD) in Progression to Advanced<br />
Disease. Tanya Glaser 1, 2 , E. Doss 1, 2 , E. Agrón 1 ,<br />
D. L. Nigam 1 , E. Y. Chew 1 , W. T. Wong 3 . 1 National<br />
Eye Institute, National Institutes of Health (NIH),<br />
Bethesda, MD; 2 School of Medicine, University<br />
of California - San Francisco, San Francisco, CA;<br />
3<br />
Office of the Scientific Director, National Eye<br />
Institute, National Institutes of Health (NIH),<br />
Bethesda, MD<br />
4152 — A0070 The evaluation of fundus autofluorescence<br />
( FAF) patterns in patient’s with<br />
Geographic Atrophy( GA) and the correlation<br />
with visual acuity. Ina K. Jaurre, S. Mudhar,<br />
N. Jain, M. Polyzos, G. Menon, L. North, M.<br />
N. Chandran. Eye treatment unit, Frimley Park<br />
Hospital, Frimley, Surrey, United Kingdom *CR<br />
4153 — A0071 Investigation into the ability<br />
of Preferential Hyperacuity Perimetry (PHP)<br />
to detect reactivation of neovascularisation in<br />
patients undergoing ranibizumab injections<br />
for age-related macular degeneration (AMD).<br />
Stephanie Mroczkowska 1 , A. Calcagni 3, 1 , J.<br />
M. Gibson 1 , U. Chakravarthy 2 , R. E. Hogg 2 .<br />
1<br />
Ophthalmic Research Group, Aston University,<br />
Birmingham, United Kingdom; 2 Centre for Vision<br />
and Vascular Science, Queen’s University Belfast,<br />
Belfast, Ireland; 3 Birmingham and Midland Eye<br />
Centre, Birmingham, United Kingdom *CR<br />
4154 — A0072 Automated Drusen<br />
Segmentation and Quantification from SD-<br />
OCT Images to Predict AMD Progression.<br />
Luis de Sisternes 1 , T. Leng 2 , Q. Chen 3 , J. Ma 2 , V.<br />
Mahendra 2 , D. Rubin 1 . 1 Radiology and Medicine,<br />
Stanford University School of Medicine, Stanford,<br />
CA; 2 Ophthalmology, Byers Eye Institute at<br />
Stanford, Palo Alto, CA; 3 School of Computer<br />
Science and Engineering, Nanjing University of<br />
Science and Technology, Nanjing, China *CR<br />
4155 — A0073 Factors that predict the<br />
incidence of fellow eye in age-related macular<br />
degeneration. Kyung Min Koh, Y. Lew, M. Choi, S.<br />
Yoo, S. Cho, D. Lee, T. Lee, C. Kim, J. Han. Kim’s<br />
Eye Hospital, Seoul, Republic of Korea<br />
4156 — A0074 Development of Choroidal<br />
Neovascularization in the Second Eye of<br />
Neovascular AMD Patients Treated with Anti-<br />
VEGF Drugs. Jonah Abraham, M. J. Elman. Elman<br />
Retina Group, PA, Baltimore, MD *CR<br />
4158 — A0076 Relationship between<br />
reflectivity and volume of subretinal tissue in<br />
choroidal neovascular membranes associated<br />
with age-related macular degeneration. Wissam<br />
Charafeddin, S. Sadda, M. Nittala, M. S. Humayun,<br />
A. A. Oregon-Miranda. Doheny eye institute, Los<br />
angeles, CA *CR<br />
4159 — A0077 Rod and Cone function and<br />
its relationship to OCT sub structural changes<br />
in Age-related Macular degeneration. Brighu<br />
Swamy 1 , E. N. Wong 3 , S. Degli Esposti 1 , P. A.<br />
Keane 2, 1 , M. D. Crossland 1 , D. A. Sim 1 , A. Tufail 1, 2 ,<br />
F. K. Chen 3 . 1 Medical Retina, Moorfields Eye<br />
Hospital, London, United Kingdom; 2 UCL Institute<br />
of Ophthalmology National Institute for Health<br />
Research Biomedical Research Centre, London,<br />
United Kingdom; 3 Lions Eye Institute, Perth, WA,<br />
Australia *CR<br />
4160 — A0078 OPERA (Optos Peripheral<br />
Retina AMD) Study Croatia: Reticular<br />
pigmentation in AMD vs. controls. Vesna Jurisic<br />
Friberg 1, 3 , B. Andrijevic Derk 2 , T. Knezevic 2 ,<br />
M. Zoric-Geber 2 , G. Bencic 2 , Z. Vatavuk 2 , T.<br />
R. Friberg 4, 2 . 1 University Eye Clinic, Clinical<br />
Center, University of Sarajevo, Sarajevo, Bosnia<br />
and Herzegovina; 2 Ophthalmology, Kbc Sestre<br />
Milosrdnice and the University of Zagreb, Zagreb<br />
Croatia, Zagreb, Croatia; 3 Ophthalmology,<br />
Children’s Hospital-UPMC, Pittsburgh, PA;<br />
4<br />
Ophthalmology, UPMC Eye Center, University of<br />
Pittsburgh, Pittsburgh, PA *CR<br />
4161 — A0079 Morphological characteristics<br />
associated with drusen progression on Spectral<br />
Domain OCT (SD-OCT). Jeong W. Pak 1 , A.<br />
Domalpally 1 , D. Myers 1 , X. Yang 2 , A. R. Narkar 1 , Y.<br />
Huang 1 , R. P. Danis 1 . 1 Ophthalmology and Visual<br />
Science, University of Wisconsin - Madison,<br />
Madison, WI; 2 Beijing Tongren Eye Center, Capital<br />
Medical University, Beijing, China *CR<br />
4162 — A0080 Clinical Outcomes of Eyes<br />
with Neovascular Lesions Composed of >50%<br />
Blood Treated with Anti-VEGF Therapy in the<br />
Comparison of AMD Treatments Trials (CATT).<br />
Michael M. Altaweel 1 , J. E. Grunwald 2 , E. Daniel 2 ,<br />
G. Ying 2 , J. Huang 2 , G. J. Jaffe 3 . 1 Ophthalmology<br />
& Visual Science, Univ of Wisconsin-Madison,<br />
Madison, WI; 2 Department of Ophthalmology,<br />
University of Pennsylvania, Philadelphia, PA;<br />
3<br />
Ophthalmology, Duke University, Durham, NC<br />
*CR, f<br />
4165 — A0083 Imaging of Focal<br />
Hyperpigmentary Changes in Intermediate Agerelated<br />
Macular Degeneration - A Longitudinal<br />
Analysis. Arno P. Goebel, S. Grundei, M.<br />
Fleckenstein, F. G. Holz, S. Schmitz-Valckenberg.<br />
Department of Ophthalmology, University of Bonn,<br />
Bonn, Germany *CR<br />
4166 — A0084 Reduction of the OCT second<br />
hyper-reflective band intensity is associated with<br />
a decreased in retinal function in eyes with agerelated<br />
macular degeneration. Chi D. Luu 1, 2 , Z.<br />
Wu 1, 2 , L. N. Ayton 1, 2 , R. H. Guymer 1, 2 . 1 Macular<br />
Research Unit, Centre for Eye Research Australia,<br />
East Melbourne, VIC, Australia; 2 Department of<br />
Ophthalmology, University of Melbourne, Parkville,<br />
VIC, Australia *CR<br />
4167 — A0085 Progression of Reticular<br />
Macular Disease (RMD) in Age-Related Macular<br />
Degeneration (AMD). Rachel M. Cymerman 1 , N.<br />
M. Pumariega 1 , A. G. Sperber 1 , N. Massamba 2 ,<br />
E. H. Souied 2 , R. Smith 1 . 1 New York University<br />
Medical Center, School of Medicine, New York,<br />
NY; 2 L’Hôpital Intercommunal de Créteil, Créteil,<br />
France *CR<br />
4168 — A0086 Imaging of reticular drusen<br />
by multi-spectral confocal scanning laser<br />
ophthalmoscopy imaging. Jasmin Anke Ilka Auge,<br />
J. S. Steinberg, M. Fleckenstein, F. G. Holz, S.<br />
Schmitz-Valckenberg. University of Bonn, Bonn,<br />
Germany *CR<br />
4169 — A0087 Reticular Pseudodrusen in<br />
Early Age-Related Macular Degeneration is<br />
Associated with Choroidal Thinning. Aakriti<br />
Garg 1 , M. Oll 1 , S. Yzer 1 , R. Allikmets 1, 2 , S. Chang 1 ,<br />
G. R. Barile 3 , R. Smith 4 , J. C. Merriam 1 , S. H.<br />
Tsang 1, 2 , S. Bearelly 1 . 1 Ophthalmology, Columbia<br />
University College of Physicians and Surgeons,<br />
New York, NY; 2 Pathology & Cell Biology,<br />
Columbia University College of Physicians and<br />
Surgeons, New York, NY; 3 Ophthalmology,<br />
Manhattan Eye, Ear, & Throat Hospital, New York,<br />
NY; 4 Ophthalmology, New York University Medical<br />
Center, New York, NY *CR<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
277
4170 – 4188 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
4170 — A0088 Reticular pseudodrusen and<br />
their topographic relation to choroidal watershed<br />
zones and localized changes in choroidal volume<br />
and choroidal thickness. Florian Alten, C. R.<br />
Clemens, N. Eter. University Eye Hosp Muenster,<br />
Muenster, Germany *CR<br />
4171 — A0089 Long-term evaluation of<br />
drusen area and volume using polarizationsensitive<br />
OCT. Ferdinand G. Schlanitz 1 , B.<br />
Baumann 2 , M. Bolz 1 , E. Gotzinger 2 , M. Pircher 2 ,<br />
C. K. Hitzenberger 2 , U. Schmidt-Erfurth 1 .<br />
1<br />
Ophthalmology, Medical University of Vienna,<br />
Vienna, Austria; 2 Center for Medical Physics and<br />
Biomedical Engineering, Medical University of<br />
Vienna, Vienna, Austria *CR<br />
4172 — A0090 Longitudinal analysis of<br />
reticular drusen associated with age-related<br />
macular degeneration. Julia S. Steinberg, J.<br />
Auge, M. Fleckenstein, F. G. Holz, S. Schmitz-<br />
Valckenberg. Department of Ophthalmology,<br />
University of Bonn, Bonn, Germany *CR<br />
4173 — A0091 Preferential Hyperacuity<br />
Perimetry Monitoring in Patients During<br />
Treatment of Neovascular Age-related Macular<br />
Degeneration. Merina Thomas 1, 2 , Y. Wolfson 1 , V.<br />
Chaikitmongkol 1, 3 , N. M. Bressler 1 . 1 Department<br />
of Ophthalmology, Retina Division, Wilmer<br />
Eye Institute, Johns Hopkins University School<br />
of Medicine, Baltimore, MD; 2 Department of<br />
Ophthalmology, University of Illinois at Chicago,<br />
Chicago, IL; 3 Department of Ophthalmology,<br />
Chiang Mai University, Chiang Mai, Thailand *CR<br />
4174 — A0092 Visual outcomes of an Inject<br />
and Extend protocol of intravitreal antivascular<br />
endothelial growth factor treatment in<br />
neovascular age-related macular degeneration<br />
over two years. Farshad Abedi, S. Wickramsinghe,<br />
A. Islam, K. M. Inglis, R. H. Guymer.<br />
Ophthalmology, Centre for Eye Research Australia,<br />
University of Melbourne, Royal Victorian Eye and<br />
Ear Hospital, East Melbourne, VIC, Australia *CR<br />
4175 — A0093 Prospective Randomized<br />
Controlled Trial of Combination Ranibizumab<br />
and Ketorolac for Wet Age-Related Macular<br />
Degeneration. Andrea Russo 1 , C. Costagliola 2 , L.<br />
Delcassi 1 , M. R. Romano 3 , F. Semeraro 1 . 1 Univ degli<br />
Studi di Brescia - Italy, Brescia, Italy; 2 Università<br />
del Molise, Campobasso, Italy; 3 Istituto Clinico<br />
Humanitas, Milano, Italy *CR<br />
4176 — A0094 Aflibercept Rescue of<br />
Bevacizumab- or Ranibizumab-Resistant<br />
Choroidal Neovascularization in Age-Related<br />
Macular Degeneration. Cheryl A. Arcinue, F. Ma,<br />
G. Barteselli, S. Lee, S. El-Emam, A. L. Doede, M.<br />
Gomez, W. Freeman. Jacobs Retina Center, UCSD<br />
Shiley Eye Center, La Jolla, CA *CR<br />
Exhibit Hall B0170-B0195<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Retinal Cell Biology<br />
415 Retinal and Photoreceptor<br />
Degeneration II: Cell Biology<br />
Moderators: Susan E. Brockerhoff and<br />
Ulrich F. Luhmann<br />
4177 — B0170 Myo/Nog Cells Promote<br />
Photoreceptor Cell Survival in the Stressed<br />
Retina. Arturo Bravo-Nuevo 1 , A. Brandli 2 , J. V.<br />
Gerhart 1 , M. Pitts 1 , J. Stone 2 , M. George-Weinstein 1 .<br />
1<br />
Lankenau Institute for Medical Research,<br />
Wynnewood, PA; 2 Physiology, University of<br />
Sydney, Sydney, NSW, Australia *CR<br />
4178 — B0171 Responsiveness of rhodopsin<br />
kinase GRK1 promoter activity to light. Shahrokh<br />
C. Khani, Z. Oskouie. Ophthalmology, Schepens<br />
Eye Research Inst, Boston, MA<br />
4179 — B0172 Early indications of pending<br />
degeneration in a mouse model of photoreceptor<br />
light damage. Emily Levine 1 , R. J. Zawadzki 2 , H.<br />
Cheng 3 , S. I. Simon 4 , E. N. Pugh 1, 5 , M. E. Burns 1, 2 .<br />
1<br />
Cell Biology and Human Anatomy, UC Davis,<br />
Davis, CA; 2 Ophthalmology & Vision Science,<br />
UC Davis, Davis, CA; 3 Neurobiology, Physiology<br />
and Behavior, UC Davis, Davis, CA; 4 Biomedical<br />
Engineering, UC Davis, Davis, CA; 5 Physiology<br />
and Membrane Biology, UC Davis, Davis, CA<br />
4180 — B0173 Constitutive Rhodopsin<br />
Activation rather than Mistrafficking Results in<br />
Photoreceptor Death in the D190N Preclinical<br />
Model of Retinitis Pigmentosa. Javier Sancho-<br />
Pelluz 1, 2 , W. Lee 1 , Y. Tsai 1 , I. Washington 1 , S. H.<br />
Tsang 1, 4 , C. Lin 3, 4 . 1 Department of Ophthalmology,<br />
Columbia University, New York, NY; 2 Department<br />
of Medicine, Catholic University of Valencia,<br />
Valencia, Spain; 3 Herbert Irving Comprehensive<br />
Cancer Center, Columbia University, New York,<br />
NY; 4 Department of Pathology and Cell Biology,<br />
College of Physicians and Surgeons, Columbia<br />
University, New York, NY<br />
4181 — B0174 Insufficient proteasomal activity<br />
is a common stress factor in multiple forms<br />
of inherited retinal degeneration. Ekaterina<br />
Lobanova, S. Finkelstein, N. P. Skiba, V. Y.<br />
Arshavsky. Albert Eye Research Institute, Durham,<br />
NC<br />
4182 — B0175 Decreased Proteasomal Activity<br />
Causes Retinal Degeneration in Mice. Ryo<br />
Ando 1, 2 , K. Noda 1, 2 , U. Tomaru 3 , M. Kamoshita 4 ,<br />
Y. Ozawa 4 , S. Notomi 5 , T. Hisatomi 5 , A. Kanda 1, 2 ,<br />
S. Ishida 1, 2 . 1 Laboratory of Ocular Cell Biology<br />
and Visual Science, Hokkaido University Graduate<br />
School of Medicine, Sapporo, Japan; 2 Department<br />
of Ophthalmology, Hokkaido University<br />
Graduate School of Medicine, Sapporo, Japan;<br />
3<br />
Department of Pathology, Hokkaido University<br />
Graduate School of Medicine, Sapporo, Japan;<br />
4<br />
Department of Ophthalmology, Keio University<br />
School of Medicine, Tokyo, Japan; 5 Department<br />
of Ophthalmology, Graduate School of Medical<br />
Sciences, Kyushu University, Fukuoka, Japan *CR<br />
4183 — B0176 Rod Photoreceptor neuritic<br />
sprouting is responsive to Sema3A. Frank<br />
Kung 1, 2 , A. Axelrod 3 , D. R. Siegel 3 , E. Townes-<br />
Anderson 1 . 1 Biomedical Engineering, UMDNJ,<br />
Newark, NJ; 2 Biomedical Engineering, NJIT,<br />
Newark, NJ; 3 Department of Chemistry and<br />
Biochemistry, The University of Texas at Austin,<br />
Chesapeake, VA<br />
4184 — B0177 Strain Dependence of Myeloid<br />
Cell-Associated Retinal Dysplasia in Crb1 rd8<br />
Mice. Mark P. Krebs, W. Hicks, L. Stone, J.<br />
Naggert, P. M. Nishina. The Jackson Laboratory,<br />
Bar Harbor, ME<br />
4185 — B0178 The genetic background<br />
determines the severity of retinal pathology<br />
in homozygous Crb1 rd8/rd8 mice. Ulrich F.<br />
Luhmann 1 , L. S. Carvalho 1 , J. Cowing 1 , P. M.<br />
Munro 4 , P. Potter 3 , J. W. Bainbridge 1, 2 , R. R.<br />
Ali 1, 2 . 1 Department of Genetics, UCL Institute<br />
of Ophthalmology, London, United Kingdom;<br />
2<br />
NIHR Moorfields Biomedical Research Centre at<br />
Moorfields Eye Hospital NHS Foundation Trust<br />
and UCL Institute of Ophthalmology, London,<br />
United Kingdom; 3 MRC Harwell, Oxfordshire,<br />
United Kingdom; 4 Imaging Unit, UCL Institute of<br />
Ophthalmology, London, United Kingdom *CR<br />
4186 — B0179 Characterization of a Novel<br />
Mouse Mutant with Retinal Degeneration and<br />
Male Infertility. Chun-hong Xia 1 , B. Chang 2 ,<br />
X. Gong 1 . 1 School of Optometry, University of<br />
California, Berkeley, Berkeley, CA; 2 The Jackson<br />
Laboratory, Bar Harbor, ME<br />
4187 — B0180 Electroretinographic and<br />
OCT Retinal Morphologic Characterization<br />
of the Crx Rdy Cat: An Animal Model for Severe<br />
Dominant Retinopathies Associated with CRX<br />
Mutations. Laurence M. Occelli 1 , J. T. Bartoe 1 ,<br />
J. R. Querubin 1 , K. Narfstrom 2 , S. M. Petersen-<br />
Jones 1 . 1 Small Animal Clinical Sciences, Michigan<br />
State University, East Lansing, MI; 2 Dept of Vet<br />
Med & Surgery, University of Missouri-Columbia,<br />
Columbia, MO<br />
4188 — B0181 Comparative analysis of<br />
neurodegenerative markers in ten different<br />
animal models for retinal degeneration<br />
reveals prevalence of non-apoptotic cell death<br />
mechanisms. Blanca Arango-Gonzalez 1 , D.<br />
Trifunović 1 , A. Sahaboglu-Tekgöz 1 , K. Kranz 2 ,<br />
S. Michalakis 3 , P. Farinelli 1, 4 , S. Cottet 5 , P.<br />
A. Ekstrom 4 , M. Ueffing 1 , F. Paquet-Durand 1 .<br />
1<br />
Institute for Ophthalmic Research, Centre for<br />
Ophthalmology, Eberhard Karls-Universität<br />
Tübingen, Tuebingen, Germany; 2 Department of<br />
Neurobiology, University of Oldenburg, Oldenburg,<br />
Germany; 3 Center for Integrated Protein Science<br />
Munich (CIPSM) and Department of Pharmacy,<br />
Center for Drug Research, Ludwig-Maximilians-<br />
Universität München, Munich, Germany; 4 Division<br />
of Ophthalmology, Department of Clinical Sciences,<br />
University of Lund, Lund, Sweden; 5 Institute<br />
for Research in Ophthalmology, University of<br />
Lausanne, Lausanne, Switzerland<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
278
<strong>Wednesday</strong> – Posters – 4189 – 4209<br />
4189 — B0182 Mechanism of cGMP-induced<br />
Retinal Degeneration. Tian Wang 1 , J. Chen 1 , S. H.<br />
Tsang 2 . 1 Zilkha Neurogenetic Institute, Keck School<br />
of Medicine, University of Southern California, Los<br />
Angeles, CA; 2 Bernard & Shirlee Brown Glaucoma<br />
Laboratory, Edward S. Harkness Eye Institute, and<br />
Department of Pathology & Cell Biology, Columbia<br />
University, New york, NY<br />
4190 — B0183 Genetic deletion of S-opsin<br />
prevents rapid cone degeneration in a mouse<br />
model of Leber congenital amaurosis. Tao<br />
Zhang 1, 2 , A. Jones 1, 2 , S. Wang 1, 2 , E. N. Pugh 3 , W.<br />
Baehr 1, 2 , Y. Fu 1, 2 . 1 Dept of Ophthalmology and<br />
Visual Sciences, University of Utah, Salt Lake City,<br />
UT; 2 Neurobiology & Anatomy, University of Utah,<br />
Salt Lake City, UT; 3 Departments of Physiology<br />
and Cell Biology, University of California, Davis,<br />
CA *CR<br />
4191 — B0184 Gene Expression Alterations<br />
in Mouse Retina with Deficiency of Cone Cyclic<br />
Nucleotide-gated Channel Subunits CNGA3 and<br />
CNGB3. Hongwei Ma 1 , A. Thapa 1 , L. M. Morris 1 ,<br />
S. Michalakis 2 , M. Biel 2 , M. B. Frank 3 , M. Bebak 3 ,<br />
X. Ding 1 . 1 The Department of Cell Biology, Univ<br />
of Oklahoma Health Sci Ctr, Oklahoma City, OK;<br />
2<br />
The Center for Integrated Protein Science Munich<br />
(CIPSM) and Department of Pharmacy - Center for<br />
Drug Research, Ludwig-Maximilians-Universität<br />
München, Munich, Germany; 3 The Arthritis and<br />
Clinical Immunology Program, Oklahoma Medical<br />
Research Foundation, Oklahoma City, OK<br />
4192 — B0185 Inhibition of S1P degradation<br />
rescues 661W cells from oxidative stress. Carlotta<br />
Fabiani, P. Signorelli, A. Caretti, R. Ghidoni.<br />
Department of Health Sciences, University of<br />
Milan, Milan, Italy<br />
4193 — B0186 Calcium fluxes in degenerating<br />
pde6c w59 mutant zebrafish cones indicate a<br />
non-apoptotic mechanism of cell death. Susan<br />
E. Brockerhoff, E. Y. Ma, A. Lewis, G. Stearns.<br />
Biochemistry, University of Washington, Seattle,<br />
WA<br />
4194 — B0187 Molecular mechanisms that<br />
contribute to vision loss in T17M RHO mice.<br />
Sonali R. Nashine 1 , Y. Bhootada 2 , A. S. Lewin 3 ,<br />
M. S. Gorbatyuk 1, 2 . 1 Cell Biology and Anatomy,<br />
Univ of North Texas Hlth Sci Ctr, Fort Worth,<br />
TX; 2 University of Alabama, Birmingham, AL;<br />
3<br />
University of Florida, Gainsville, FL *CR<br />
4197 — B0190 Interaction of Tubby-like<br />
protein-1 (Tulp1) and Microtubule-Associated<br />
Proteins (MAPs) in the Mouse Retina. Lindsey<br />
A. Ebke 1 , G. H. Grossman 1 , C. D. Beight 1 , G. J.<br />
Pauer 1 , S. A. Hagstrom 1, 2 . 1 Cole Eye Institute,<br />
Cleveland Clinic, Cleveland, OH; 2 Department of<br />
Ophthalmology, Cleveland Clinic Lerner College<br />
of Medicine of Case Western Reserve University,<br />
Cleveland, OH<br />
4198 — B0191 The Protective effects<br />
of Resveratrol in Experimental Retinal<br />
Detachment. Wei Huang, G. Li, J. Qiu, P.<br />
Gonzalez, P. Challa. Ophthalmology, Duke Eye<br />
Center, Durham, NC<br />
4199 — B0192 LED light source induced<br />
retinal photoreceptor hazard in a rat model.<br />
Yu-Man Shang 1, 2 , C. Yang 2, 3 , G. Wang 1, 4 , L. Lin 1, 2 .<br />
1<br />
Institute of Environmental Health, National<br />
Taiwan University, Taipei, Taiwan; 2 Department<br />
of Ophthalmology, National Taiwan University<br />
Hospital, Taipei, Taiwan; 3 College of Medicine,<br />
National Taiwan University, Taipei, Taiwan;<br />
4<br />
Department of Public Health, National Taiwan<br />
University, Taipei, Taiwan<br />
4200 — B0193 Neuroprotective effects of<br />
norgestrel in retinitis pigmentosa: preservation<br />
of retinal cytoarchitecture and synaptic<br />
connectivity. Violeta Gomez-Vicente 1 , L.<br />
Fernandez-Sanchez 1 , G. Groeger 2 , F. Doonan 2 , T.<br />
G. Cotter 2 , N. Cuenca 1 . 1 Physiology, Genetics &<br />
Microbiology, University of Alicante, Alicante,<br />
Spain; 2 Biochemistry, BioSciences Institute,<br />
University College Cork, Cork, Ireland *CR<br />
4201 — B0194 Manipulating MSC Homing<br />
To Enhance Its Efficacy in Preserving Vision.<br />
Shaomei Wang 1 , Y. Tsai 1 , S. Girman 1 , L. Shen 1 ,<br />
C. W. Morgans 2 , G. Adamus 3 , W. Xiong 1 , V.<br />
Arumugaswami 1 , C. Svendsen 1 , B. Lu 1 . 1 Biomedical<br />
Science, Regenerative Medicine Institute, Los<br />
Angeles, CA; 2 Physiology & Pharmacology,<br />
OHSU, Portland, OR; 3 Casey Eye Institute, OHSU,<br />
Portland, OR<br />
4202 — B0195 NecroX-5 Rescue Retinal<br />
Degeneration Induced by N-methyl-Nnitrosourea<br />
in Rats. Sun-Sook Paik, J. Jeon, I.<br />
Kim. Anatomy, College of Medicine, The Catholic<br />
University of Korea, Seoul, Republic of Korea<br />
Exhibit Hall B0196-B0249<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Anatomy/Pathology / Physiology/Pharmacology<br />
416 Uveal Melanoma<br />
Moderators: Tatyana Milman and Rebecca Stacy<br />
4203 — B0196 Comparison of Two Melanoma<br />
Cell Lines as Mouse-Models of Uveal Melanoma.<br />
Marta M. Kilian 1 , K. U. Loeffler 1 , H. E.<br />
Grossniklaus 2 , F. G. Holz 1 , C. Pfarrer 3 , C. Kurts 4 ,<br />
M. C. Herwig 1 . 1 Department of Ophthalmology,<br />
University of Bonn, Bonn, Germany; 2 Department<br />
of Ophthalmology, Emory University, Atlanta, GA;<br />
3<br />
Department of Anatomy, University of Veterinary<br />
Medicine Hannover, Hannover, Germany;<br />
4<br />
Institutes of Molecular Medicine and Experimental<br />
Immunology, University of Bonn, Bonn, Germany<br />
*CR<br />
4204 — B0197 Calcium regulation by transient<br />
receptor potential channels in human uveal<br />
melanoma cells. Stefan Mergler 1 , A. Boehm 1 , R.<br />
Derckx 1 , L. Schmelzer 1 , F. Garreis 2 , A. Riechardt 1 .<br />
1<br />
Department of Ophthalmology, University<br />
Medicine Charite Berlin, Berlin, Germany;<br />
2<br />
Department of Anatomy II, University Erlangen-<br />
Nuremberg, Erlangen, Germany<br />
4205 — B0198 Unusual sodium-potassium<br />
dynamics and Na,K-ATPase expression in Mel-<br />
290 uveal melanoma cells. Elena B. Rodriguez de<br />
Turco, N. A. Delamere, M. Shahidullah. Physiology,<br />
University of Arizona, Tucson, AZ<br />
4206 — B0199 Host Pigment Epithelium-<br />
Derived Factor (PEDF) Prevents Progression<br />
of Uveal Melanoma Metastasis in the Liver<br />
and Inhibits Formation of Blood Vessels in the<br />
Metastatic Microenvironment. John M. Lattier 1 ,<br />
H. Yang 1 , S. Crawford 2 , H. E. Grossniklaus 1 . 1 Dept.<br />
of Ophthalmology, Emory University, Atlanta, GA;<br />
2<br />
Dept. of Pathology, University of St. Louis, St.<br />
Louis, MO<br />
4207 — B0200 Pre-clinical analysis of<br />
Crizotinib in MAPK independent uveal<br />
melanoma metastases. Pieter van der Velden, M.<br />
de Lange, M. Versluis, G. P. Luyten, M. M. Jager.<br />
Ophthalmology, LUMC, Leiden, Netherlands<br />
4208 — B0201 Vemurafenib as a therapeutic<br />
option for treatment of melanoma. Simon F.<br />
Leicht, C. M. Wertheimer, R. Liegl, A. Kampik,<br />
K. Eibl-Lindner. Department of Ophthalmology,<br />
Ludwig-Maximilians-University, Munich, Germany<br />
*CR<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
4195 — B0188 Extracellular ATP accelerates<br />
photoreceptor cell death via ligation of P2X7<br />
receptor in retinal detachment. Shoji Notomi,<br />
T. Hisatomi, Y. Murakami, A. Takeda, Y. Ikeda,<br />
H. Enaida, T. Ishibashi. Ophthalmology, Kyushu<br />
University, Fukuoka, Japan *CR<br />
4196 — B0189 Identification and<br />
characterization of Tubby C-terminal binding<br />
proteins by ORF phage display. Nora B.<br />
Caberoy 1 , G. S. Alvarado 2 , J. N. Nocillado 1 . 1 School<br />
of Life Sciences, University of Nevada Las Vegas,<br />
Las Vegas, NV; 2 Ophthalmology, Bascom Palmer<br />
Eye Institute, University of Miami Miller School of<br />
Medicinel, Miami, FL<br />
4209 — B0202 5-Azacytidine Reduces<br />
Growth, Invasiveness, and Clonogenicity of<br />
Uveal Melanoma Cells and Decreases the Rate<br />
of Metastasis. Fatemeh Rajaii, L. Asnaghi, S.<br />
L. Merbs, J. T. Handa, C. Eberhart. Department<br />
of Ophthalmology, Wilmer Eye Institute, Johns<br />
Hopkins University, Baltimore, MD *CR<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
279
4210 – 4233 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
4210 — B0203 Cytotoxic Effects of the<br />
Combination of Resveratrol and N-acetylcysteine<br />
on Cultured Human Uveal Melanoma Cells.<br />
Tommaso Vagaggini 1, 2 , D. Hu 2 , A. Sclafani 2 , S. A.<br />
McCormick 2 , J. E. Roberts 1 . 1 Natural Sciences,<br />
Fordham University, New York, NY; 2 Pathology,<br />
New York Eye and Ear Infirmary, New York, NY<br />
*CR<br />
4211 — B0204 Simultaneous Inhibition of<br />
the HGF/MET and Erk1/2 Pathways Affect<br />
Uveal Melanoma Cell Growth and Migration.<br />
Chandrani Chattopadhyay, E. A. Grimm, S. E.<br />
Woodman. Melanoma Medical Oncology, UT MD<br />
Anderson Cancer Ctr, Houston, TX *CR<br />
4212 — B0205 Cyclooxygenase-2 (COX-2)<br />
expression in primary uveal melanoma and the<br />
potential role for adjuvant treatment with COX-<br />
2 inhibitors. Lindsay E. Adam, J. B. Massengill, C.<br />
M. Cebulla, M. H. Abdel-Rahman. Ophthalmology,<br />
The Ohio State University, Columbus, OH<br />
4213 — B0206 Antimicrobial Peptide<br />
Expression and Potential Roles in Uveal<br />
Melanoma Pathogenesis. Joseph C. Manarang,<br />
D. C. Otteson, A. Glasser, A. R. Burns, A. M.<br />
McDermott. College of Optometry, University of<br />
Houston, Houston, TX<br />
4214 — B0207 Improved Specimen Handling<br />
for Optimizing Diagnostic Yield from Fine<br />
Needle Aspiration Biopsy of Uveal Tumors.<br />
Nieraj Jain, V. M. Elner, H. Demirci. University of<br />
Michigan, Ann Arbor, MI *CR<br />
4215 — B0208 Heterogeneity of Monosomy 3<br />
in Fine Needle Aspiration Biopsy of Choroidal<br />
Melanoma. Melinda Chang, N. Rao, L. Johnson, T.<br />
McCannel. Jules Stein Eye Institute, Los Angeles,<br />
CA<br />
4216 — B0209 Prognostic FNAB of Uveal<br />
Melanoma. Arun D. Singh 1, 5 , M. E. Aronow 1 , C.<br />
V. Biscotti 2 , R. Tubbs 3 , L. Schoenfield 2 , P. Triozzi 4,<br />
5<br />
. 1 Ophthalmic Oncology, Cole Eye Institute,<br />
Cleveland, OH; 2 Anatomic Pathology, Cleveland<br />
Clinic, Cleveland, OH; 3 Molecular Pathology,<br />
Cleveland Clinic, Cleveland, OH; 4 Solid tumor<br />
Oncology, Cleveland Clinic, Cleveland, OH;<br />
5<br />
Taussig Cancer Center, Cleveland Clinic,<br />
Cleveland, OH<br />
4217 — B0210 Extraocular Extension of<br />
Uveal Melanoma After Fine Needle Aspiration,<br />
Vitrectomy, or Open Biopsy. Amy C. Schefler 1 , D.<br />
Gologorsky 2 , B. Marr 3 , C. L. Shields 4 , I. Zeolite 5 ,<br />
D. H. Abramson 3 . 1 Retina Consultants of Houston,<br />
Houston, TX; 2 Geisel School of Medicine at<br />
Dartmouth, Hanover, NH; 3 Ophthalmic Oncology,<br />
Memorial Sloan-Kettering Cancer Center, New<br />
York, NY; 4 Oncology Service, Wills Eye Institute,<br />
Philadelphia, PA; 5 Ophthalmology, Universidad de<br />
Mendoza, Mendoza, Argentina<br />
4218 — B0211 A comparison of gene<br />
expression profiling versus multiplex ligationdependent<br />
probe amplification in metastatic<br />
risk prediction in choroidal melanoma. Sarah<br />
E. Coupland 1 , B. E. Damato 1 , H. Kalirai 1 , M.<br />
Baudo 1 , C. Bergstrom 2 , J. R. Wells 2 , T. Kivela 3 , H.<br />
E. Grossniklaus 2 . 1 Pathology, Univ of Liverpool/<br />
Sydney Jones Library, Liverpool, United Kingdom;<br />
2<br />
Department of Ophthalmology, Emory University<br />
School of Medicine, Atlanta, GA; 3 Department<br />
of Ophthalmology, Helsinki University Central<br />
Hospital, Helsinki, Finland<br />
4219 — B0212 Prognostic implications of<br />
GEP class 2 in clinical practice: a single center<br />
experience with 273 cases. James J. Augsburger,<br />
Z. M. Correa. Ophthalmology, University of<br />
Cincinnati, Cincinnati, OH<br />
4220 — B0213 Choroidal Melanoma<br />
pronostication: a robust and costless classifying<br />
system. Nathalie Cassoux 1 , L. Desjardins 1 , C.<br />
Plancher 2 , B. Asselain 2 , C. Levy-Gabrielle 1 , L.<br />
Lumbroso-Le Rouic 1 , M. J. Rodrigues 4 , X. Sastre 5 , S.<br />
Piperno-Neumann 4 , J. Couturier 3 . 1 Ophthalmology,<br />
Institut Curie, Paris, France; 2 biostatistics, Institut<br />
Curie, Paris, France; 3 Genetics, Institut Curie, Paris,<br />
France; 4 Oncology, Institut Curie, Paris, France;<br />
5<br />
Pathology, Institut Curie, Paris, France *CR<br />
4221 — B0214 Relationship between rate of<br />
choroidal melanoma flattening following plaque<br />
radiotherapy and GEP class of tumor cells.<br />
Zelia M. Correa, J. J. Augsburger. Ophthalmology,<br />
University of Cincinnati, Cincinnati, OH<br />
4222 — B0215 The role of Osteopontin<br />
expression in the mechanism of invasion and<br />
metastasis potential in Uveal Melanoma. Bin<br />
Li. Beijing Institute of Ophthalmology, Beijing<br />
TongRen Hospital, Beijing, China<br />
4223 — B0216 BAP1 mutations in uveal<br />
melanoma. Anna E. Koopmans 1, 2 , R. M. Verdijk 3 ,<br />
T. van den Bosch 3 , M. M. van den Berg 1, 2 , J.<br />
Vaarwater 1 , D. Paridaens 4 , E. Kilic 1 , A. de Klein 2 .<br />
1<br />
Ophthalmology, Erasmus Medical Centre,<br />
Rotterdam, Netherlands; 2 Clinical Genetics,<br />
Erasmus Medical Centre, Rotterdam, Netherlands;<br />
3<br />
Pathology, Erasmus Medical Centre, Rotterdam,<br />
Netherlands; 4 The Rotterdam Eye Hospital,<br />
Rotterdam, Netherlands<br />
4224 — B0217 Gender differences and<br />
estrogen and progesterone receptor expression<br />
in uveal melanoma. Lynn Schoenfield 1 , T. Plesec 2 ,<br />
E. Downs-Kelly 2 , M. Aronow 3 , P. Carver 2 , R.<br />
Tubbs 2 , A. D. Singh 3 . 1 Pathology, Ohio State<br />
University Wexner Medical Center, Columbus, OH;<br />
2<br />
Pathology, Cleveland Clinic, Cleveland, OH; 3 Eye<br />
Institute, Cleveland Clinic, Cleveland, OH<br />
4225 — B0218 Detection of circulating tumor<br />
cells in uveal melanoma using the CellSearch ®<br />
system. Martina Angi 1 , L. Khoja 3, 4 , B. E. Damato 2 ,<br />
P. Lorigan 3 , C. Dive 4 , S. E. Coupland 1 , H. Kalirai 1 .<br />
1<br />
Department of Molecular & Clinical Cancer<br />
Medicine, University of Liverpool, Liverpool,<br />
United Kingdom; 2 Royal Liverpool University<br />
Hospital, Liverpool, United Kingdom; 3 The Christie<br />
NHS Foundation Trust, Manchester, United<br />
Kingdom; 4 Paterson Institute for Cancer Research,<br />
Manchester, United Kingdom<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
280<br />
4226 — B0219 Quantification of circulating<br />
tumour cells in patients with choroidal<br />
melanocytic tumours: correlation with clinical<br />
risk factors. Manuel F. Bande 1 , M. Santiago 1 ,<br />
P. Mera 1 , M. Blanco 1 , L. Muinelo-Romay 3 ,<br />
C. Capeans 1 , M. Pardo 2 , A. Piñeiro 1 . 1 Ocular<br />
Oncology Unit. Servizo de Oftalmoloxía.<br />
Complexo Hospitalario Universitario de Santiago.<br />
Universidade de Santiago de Compostela. Santiago<br />
de Compostela. Spain, Santiago de Compostela,<br />
Spain; 2 Grupo Obesidómica, Laboratorio de<br />
Endocrinología Molecular y Celular, Hospital<br />
Clínico Universitario de Santiago (CHUS/<br />
SERGAS), Spain, Santiago de Compostela,<br />
Spain; 3 Unit of circulating tumor cells analysis.<br />
Traslational laboratory/ Medical Oncology<br />
Department. Complexo Hospitalario Universitario<br />
de Santiago de Compostela Santiago de<br />
Compostela, Spain., Santiago de Compostela, Spain<br />
4227 — B0220 Systemic Surveillance for<br />
Metastases in patients with Uveal Melanoma.<br />
Maria M. Choudhary 1 , A. Gupta 2 , J. Bena 3 , A.<br />
D. Singh 2 . 1 Internal Medicine, Cleveland Clinic<br />
Foundation, Cleveland, OH; 2 Department of<br />
Ophthalmology, Cleveland Clinic Foundation,<br />
Cleveland, OH; 3 Quantitative Health Sciences,<br />
Cleveland Clinic Foundation, Cleveland, OH<br />
4228 — B0221 Detecting hepatic metastases<br />
from ocular melanoma using MRI with a<br />
novel designed contrast agent. Hua Yang 1 , H. E.<br />
Grossniklaus 1 , Q. Zhang 1 , S. Xue 2 , F. Pu 2 , J. Qiao 2 ,<br />
Z. Liu 2 , R. C. Long 3 , J. Yang 2 . 1 Ophthalmology,<br />
Emory University Eye Center, Atlanta, GA;<br />
2<br />
Chemistry, Georgia State University, Atlanta, GA;<br />
3<br />
Radiology, Emory University, Atlanta, GA<br />
4229 — B0222 In vivo contrast-enhanced<br />
high-frequency ultrasonography of<br />
experimental uveal melanoma: imaging<br />
features and histopathologic correlations. Hans<br />
E. Grossniklaus, S. J. Kang, Q. Zhang. Dept of<br />
Ophthal, School of Med, Emory University, Atlanta,<br />
GA<br />
4230 — B0223 Enhanced Depth Imaging<br />
Optical Coherence Tomography of Choroidal<br />
Melanoma Before and After Plaque<br />
Radiation Therapy. Denise S. Kim, H. Demirci.<br />
Ophthalmology & Visual Sciences, University of<br />
Michigan Kellogg Eye Center, Ann Arbor, MI<br />
4231 — B0224 Enhanced Depth Imaging<br />
Optical Coherence Tomography of Tumors of<br />
the Retina and Choroid: Comparison to B-scan<br />
ultrasonography. Euiyong Kweon 1, 2 , J. G. Frisch 3 ,<br />
P. G. Hovland 1 . 1 Colorado Retinal Associates,<br />
Denver, CO; 2 Department of Ophthalmology,<br />
Chonbuk National University Hospital, Jeonju,<br />
Republic of Korea; 3 Roocky Vista University<br />
Medical School, Denver, CO<br />
4232 — B0225 EDI-OCT Findings in Unilateral<br />
Choroidal Melanocytosis with Macular<br />
Involvement. Sruthi Arepalli, M. Pellegrini, C.<br />
L. Shields. Ocular Oncology, Wills Eye Institute,<br />
Philadelphia, PA<br />
4233 — B0226 Macular Choroidal Thickness<br />
in Uveal Melanoma Patients treated with Plaque<br />
Radiotherapy. Ira H. Schachar, H. Demirci.<br />
Ophthalmology, University of Michigan, Ann<br />
Arbor, MI
<strong>Wednesday</strong> – Posters – 4234 – 4256<br />
4234 — B0227 Radiation Therapy for Small<br />
Choroidal Melanoma: 10-years Experience<br />
with Palladium-103 Plaque Radiation Therapy.<br />
Kimberly J. Chin, E. Semenova, P. T. Finger. The<br />
New York Eye Cancer Center, New York, NY *CR<br />
4235 — B0228 Plaque Radiation Therapy for<br />
Large and Extra-large Choroidal Melanoma.<br />
Ekaterina Semenova 1, 2 , P. T. Finger 1, 2 . 1 Ocular<br />
Oncology, The New York Eye Cancer Center, New<br />
York, NY; 2 Ocular Oncology, The New York Eye<br />
and Ear Infirmary, New York, NY *CR<br />
4236 — B0229 Proton beam radiation for the<br />
treatment of large choroidal melanoma. Shideh<br />
Schoenfeld. charite Berlin, ophthalmology, Berlin,<br />
Germany<br />
4237 — B0230 Outcomes of Choroidal<br />
Melanomas Treated with Eye Physics ® plaques: a<br />
20-year Review. Jesse L. Berry 1 , S. V. Dandapani 2 ,<br />
M. Stevanovic 3 , M. Astrahan 2 , A. L. Murphree 4 , J.<br />
W. Kim 1, 4 . 1 Doheny Eye Institute and Department<br />
of Ophthalmology, Keck School of Medicine of the<br />
University of Southern California, Los Angeles,<br />
CA; 2 Department of Radiation Oncology, Keck<br />
School of Medicine of the University of Southern<br />
California, Los Angeles, CA; 3 Harvard College,<br />
Cambridge, MA; 4 Ophthalmology, The Vision<br />
Center at Children’s Hospital Los Angeles, Los<br />
Angeles, CA *CR<br />
103<br />
4238 — B0231 Pd versus 125 I Plaque<br />
Radiation Dose to Normal Ocular Structures<br />
in the Treatment of 319 Uveal Melanomas. Di<br />
Zhou 1, 4 , E. Semenova 1, 3 , P. Wong 2 , N. Kalach 2 , W.<br />
Choi 2, 3 , P. T. Finger 1, 4 . 1 The New York Eye Cancer<br />
Center, New York, NY; 2 Beth Israel Comprehensive<br />
Cancer Center, New York, NY; 3 The New York<br />
Eye and Ear Infirmary, New York, NY; 4 New York<br />
University School of Medicine, New York, NY *CR<br />
4239 — B0232 High Dose Rate Interstitial<br />
Radiation Therapy for Orbital Melanoma.<br />
Paul T. Finger 1, 3 , L. B. Tena 2 , P. Aridgides 2 , E.<br />
Semenova 1, 3 , W. Choi 2, 3 . 1 Ophthalmic Oncology,<br />
The New York Eye Cancer Center, New York, NY;<br />
2<br />
Radiation Oncology, Beth Israel Comprehensive<br />
Cancer Center, New York, NY; 3 Ophthalmology,<br />
The New York Eye and Ear Infirmary, New York,<br />
NY *CR<br />
4240 — B0233 Intravitreal Bevacizumab<br />
Therapy In the Management of Radiation<br />
Maculopathy. Andrew W. Stacey, H. Demirci.<br />
Ophthalmology, University of Michigan - Kellogg<br />
Eye Center, Ann Arbor, MI<br />
4241 — B0234 Autocrine impact of VEGF<br />
ligands in uveal melanoma cells. Konrad R.<br />
Koch 1 , D. Hos 1 , B. Regenfuss 1 , F. Bock 1 , J. J.<br />
Bosch 2 , C. Cursiefen 1 , L. M. Heindl 1 . 1 Center of<br />
Ophthalmology, University of Cologne, Cologne,<br />
Germany; 2 Department of Internal Medicine 5,<br />
Hematology and Oncology, University of Erlangen-<br />
Nuremberg, Erlangen, Germany *CR<br />
4242 — B0235 Symptomatic Macular<br />
Melanocytic Lesions Treated with Intravitreal<br />
Bevacizumab. Jella A. An 1 , C. Corriveau 2 , M.<br />
Sebag 1, 2 , S. A. Callejo 1, 2 . 1 Ophthalmology, McGill<br />
University, Montreal, QC, Canada; 2 Ophthalmology,<br />
Centre Hospitalier de l’Université de Montréal,<br />
Montreal, QC, Canada *CR<br />
4243 — B0236 Minimally invasive therapy<br />
of exudative retinal detachment (ERD) due<br />
to choroidal or ciliary body melanoma after<br />
irradiation therapy compared to endoresection.<br />
Ira Seibel 1 , D. Cordini 2 , G. Willerding-Beaucamp 1 ,<br />
J. Heufelder 2 , A. M. Joussen 1 . 1 Department of<br />
Ophthalmology, Charité University Medicine,<br />
Berlin, Germany; 2 Proton beam therapy, Helmholtz-<br />
Zentrum Berlin für Materialien und Energie - Lise-<br />
Meitner-Campus, Berlin, Germany<br />
4244 — B0237 Detection of Extrascleral<br />
Extension in Uveal Melanoma. Christopher<br />
Burris 1 , V. Papastefanou 2, 3 , C. Thaung 4 , M. S.<br />
Sagoo 2, 3 , V. Cohen 2, 3 . 1 Ophthalmology, Howard<br />
University College of Medicine, Washington, DC;<br />
2<br />
Ocular Oncology, St. Bartholomew’s Hospital,<br />
London, United Kingdom; 3 Ocular Oncology,<br />
Moorfields Eye Hospital, London, United Kingdom;<br />
4<br />
Eye Pathology, UCL Institute of Ophthalmology,<br />
London, United Kingdom<br />
4245 — B0238 Extraocular extension in uveal<br />
melanoma. Jackelien van Beek 1 , A. E. Koopmans 1, 2 ,<br />
J. Vaarwater 2 , A. de Klein 2 , R. M. Verdijk 3 , E.<br />
Kilic 1, 2 . 1 Ophthalmology, Erasmus MC Rotterdam,<br />
Rotterdam, Netherlands; 2 Clinical Genetics,<br />
Erasmus MC Rotterdam, Rotterdam, Netherlands;<br />
3<br />
Pathology, Erasmus MC Rotterdam, Rotterdam,<br />
Netherlands<br />
4246 — B0239 Ciliary Body and Choroidal<br />
Pseudomelanoma from Hypermature Cataract<br />
in 20 Cases. Marco Pellegrini, C. L. Shields, B.<br />
E. Kligman, C. G. Bianciotto, J. Shields. Ocular<br />
Oncology Service, Wills Eye Institute, Philadelphia,<br />
PA<br />
4247 — B0240 Prevalence of Asteroid Hyalosis<br />
in Human and Canine Melanoma Eyes.<br />
Heather Potter 1 , M. Rezaei Kanavi 1, 2 , A. Azari 1 ,<br />
R. R. Dubielzig 1 , D. M. Albert 1 . 1 Ophthalmology,<br />
University of Wisconsin, Madison, WI; 2 Ophthalmic<br />
Research Center, Shahid Beheshti University of<br />
Medical Sciences, Tehran, Islamic Republic of Iran<br />
*CR<br />
4248 — B0241 Pain as presenting feature of<br />
uveal melanoma. Pukhraj Rishi 1, 2 , C. L. Shields 1 ,<br />
K. A. Patrick 1 , M. A. Khan 1 , J. Shields 1 . 1 Ocular<br />
Oncology Service, Wills Eye Institute, Philadelphia,<br />
PA; 2 Sankara Nethralya, Chennai, India<br />
4249 — B0242 Analysis of the quality of life<br />
of patients receiving conservative treatment for<br />
uveal melanoma. Federica Genovesi-Ebert 1 , C.<br />
Meo 2 , F. Perrone 3 , C. Meo 2 , F. Cresti 1 , P. Ferrazza 2 ,<br />
S. Rizzo 1 . 1 U.O. Chirurgia Oftalmica, Azienda<br />
Ospedaliera Universitaria Pisana, Livorno, Italy;<br />
2<br />
Radiotherapy Department, Azienda Ospedaliera<br />
Universitaria Pisana, Pisa, Italy; 3 Sanitary Physics,<br />
Azienda Ospedaliera Universitaria Pisana, Pisa,<br />
Italy<br />
Exhibit Hall B0287-B0320<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Visual Psychophysics / Physiological Optics<br />
417 Accommodation and Presbyopia<br />
Correction<br />
Moderators: Abhiram S. Vilupuru and<br />
Fabrice Manns<br />
4250 — B0287 The Influence of Multifocal<br />
Lenses on Fine Motor Tasks. Rupal Lovell-<br />
Patel 1, 2 , M. A. Timmis 2 , S. Pardhan 2 , P. McCarthy 1, 2 .<br />
1<br />
Vision and Hearing Sciences, Anglia Ruskin<br />
University, Cambridge, United Kingdom; 2 Vision<br />
and Eye Research Unit, Anglia Ruskin University,<br />
Cambridge, United Kingdom<br />
4251 — B0288 Accommodative Lag, Facility<br />
and Phoria with Multifocal Contact Lenses.<br />
Jiyoon Chung 1 , R. C. Bakaraju 1 , C. Fedtke 1 , J.<br />
Ozkan 1 , K. Ehrmann 1, 2 , D. Falk 1 , A. Ho 1, 2 , B. A.<br />
Holden 1, 2 . 1 Brien Holden Vision Institute, Sydney,<br />
NSW, Australia; 2 School of Optometry and Vision<br />
Science, University of New South Wales, Sydney,<br />
NSW, Australia *CR, f<br />
4252 — B0289 The role of eye dominance<br />
on through-focus visual performance in<br />
modified monovision presbyopic corrections.<br />
Len Zheleznyak 1, 2 , A. Alarcon 2 , K. C. Dieter 3 ,<br />
D. Tadin 3, 2 , G. Yoon 2, 1 . 1 The Institute of Optics,<br />
University of Rochester, Rochester, NY; 2 Flaum<br />
Eye Institute, University of Rochester, Rochester,<br />
NY; 3 Brain and Cognitive Sciences, University of<br />
Rochester, Rochester, NY *CR<br />
4253 — B0290 Customizing depth of focus<br />
outcomes in Hyperopic Lasik using an Adaptive<br />
Optics Vision Analyzer. Guillermo M. Perez 1 , E.<br />
A. Villegas 2 , B. Leray 3 , F. J. Malecaze 3 , P. Artal 2 .<br />
1<br />
Voptica S.L., Murcia, Spain; 2 Laboratorio de<br />
Optica, Universidad de Murcia, Murcia, Spain;<br />
3<br />
Service d’Ophtalmologie, CHU Toulouse-Purpan,<br />
Toulouse, France *CR<br />
4254 — B0291 Effect of Age on Amplitude of<br />
Accommodation in Bolivia. Magnus Andersson,<br />
B. Theagarayan. Section of Optometry and Vision<br />
Science, Linnaeus University, Kalmar, Sweden<br />
4255 — B0292 Influences of cycloplegia<br />
with topical cyclopentolate on higher-order<br />
aberrations in myopic children. Takahiro<br />
Hiraoka 1 , K. Miyata 2 , F. Okamoto 1 , T. Oshika 1 .<br />
1<br />
Dept of Ophthalmology, University of Tsukuba,<br />
Tsukuba, Japan; 2 Miyata Eye Hospital, Miyakonojo,<br />
Japan<br />
4256 — B0293 Five-year Incidence of Loss<br />
of Accommodative Ability in the Beaver<br />
Dam Offspring Study. Dayna S. Dalton, K. J.<br />
Cruickshanks, M. E. Fischer, B. E. Klein, R. Klein,<br />
A. A. Pinto. Ophthalmology and Visual Sciences,<br />
University of Wisconsin, Madison, WI<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
281
4257 – 4279 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
4257 — B0294 Effect of Unclean Display on<br />
Accommodative Response. Masakazu Hirota 1 , H.<br />
Uozato 1, 2 , S. Arai 1 , Y. Shibata 1 . 1 Ophthalmology &<br />
Visual Sciences, Kitasato Univ Graduate School,<br />
Minami-ku, Sagamihara-shi, Japan; 2 Orthoptics<br />
& Visual Sciences, Kitasato University School of<br />
Allied Health Science, Minami-ku, Sagamihara-shi,<br />
Japan<br />
4258 — B0295 The effect of near addition<br />
lenses on the accuracy of the accommodative<br />
response in myopic children during reading.<br />
Jinhua Bao, Z. Zheng, H. Chen. School of<br />
Optometry and Ophthalmology, Wenzhou Medical<br />
College, Wenzhou, China<br />
4259 — B0296 Tonic Accommodation<br />
Correlates with Accommodative Amplitude-<br />
Scaled Facility Test for Symptomatic Graduate<br />
Students. Chunming Liu 1 , C. Chase 1 , S. A. Drew 3 ,<br />
E. Castellanos 1 , A. Escobar 1 , E. Borsting 2 , L.<br />
R. Stark 2 . 1 Optometry, Western University of<br />
Health Sciences College of Optometry, Pomona,<br />
CA; 2 Southern California College of Optometry,<br />
Fullerton, CA; 3 California State University,<br />
Northridge, Northridge, CA<br />
4260 — B0297 Larger Tonic Accommodation<br />
Correlates with Better Focus at Near for<br />
Symptomatic Graduate School Students. Chris<br />
Chase 1 , S. A. Drew 3 , A. Escobar 1 , C. Liu 1 , E.<br />
Castellanos 1 , L. R. Stark 2 , E. Borsting 2 . 1 College of<br />
Optometry, Western University of Health Sciences,<br />
Pomona, CA; 2 Southern California College of<br />
Optometry, Fullerton, CA; 3 California State<br />
University, Northridge, Northridge, CA f<br />
4261 — B0298 The Dynamic Accommodative<br />
Response with the Binocular open-field<br />
autorefractor and a Movable Real Target. Shinji<br />
Arai 1 , H. Uozato 1, 2 , M. Hirota 1 . 1 Department of<br />
Visual Science, Kitasato University Graduate<br />
School of Medical Sciences, Kanagawa, Japan;<br />
2<br />
Department Orthoptics and Visual Sciences,<br />
Kitasato University School of Allied Health<br />
Science, Kanagawa, Japan<br />
4262 — B0299 Suppression in the<br />
accommodative response to short-duration<br />
changes in dioptric stimulus. Alistair P. Curd,<br />
K. M. Hampson, E. Mallen. Bradford School of<br />
Optometry and Vision Science, University of<br />
Bradford, Bradford, United Kingdom<br />
4263 — B0300 Accommodation induced<br />
variations of ocular axial length and retinal<br />
thickness measured with SD-OCT. Chuanqing<br />
Zhou, S. Fan, Z. Chen, X. Chai. Biomedical<br />
Engineering, Shanghai Jiao Tong University,<br />
Shanghai, China<br />
4264 — B0301 The Effect Of Age On The<br />
Lens Ultrastructure During Accommodation As<br />
Measured Using Slit Lamp Photos And Wave<br />
Front Analysis. Rebecca K. Zoltoski 1 , E. Wyles 1 ,<br />
J. S. Harthan 1 , J. R. Kuszak 2 . 1 Illinois College of<br />
Optometry, Chicago, IL; 2 LensAR, Orlando, FL<br />
*CR<br />
4265 — B0302 Do Higher Order Aberrations<br />
Affect the Magnitude of Odd-error Temporal<br />
Stimuli to Accommodation? Sangeetha<br />
Metlapally 1 , J. Tong 2 , H. J. Tahir 3, 1 , C. M. Schor 1 .<br />
1<br />
School of Optometry, University of California at<br />
Berkeley, Berkeley, CA; 2 Brain Trauma Foundation,<br />
New York, NY; 3 University of Manchester,<br />
Manchester, United Kingdom<br />
4266 — B0303 Impact of pupil amplitude<br />
apodization on through-focus image quality<br />
with spherical aberration. Hae Won Jung 1, 2 , L.<br />
Zheleznyak 1, 2 , G. Yoon 2, 1 . 1 The Institute of Optics,<br />
University of Rochester, Rochester, NY; 2 Flaum<br />
Eye Institute, University of Rochester, Rochester,<br />
NY *CR<br />
4267 — B0304 Contribution of shape and<br />
gradient index to the spherical aberration of<br />
donor human lenses. Judith Birkenfeld, A. de<br />
Castro, S. Marcos. CSIC-Instituto de Optica,<br />
Madrid, Spain *CR<br />
4268 — B0305 Crystalline lens thickness<br />
determines transverse chromatic aberration. Yun<br />
Chen, F. Schaeffel. Section of neurobiology of the<br />
Eye, Institute for Ophthalmic Research, Tuebingen,<br />
Germany<br />
4269 — B0306 Prediction of human crystalline<br />
lens power and spherical aberration using an<br />
anatomically-based discrete shell model. Fabrice<br />
Manns 1, 2 , A. Ho 3, 4 , J. A. Parel 1, 5 . 1 Ophthalmic<br />
Biophysics Center, Bascom Palmer Eye Inst, Univ<br />
of Miami, Miami, FL; 2 Department of Biomedical<br />
Engineering, University of Miami College of<br />
Engineering, Coral Gables, FL; 3 Brien Holden<br />
Vision Institute, Sydney, NSW, Australia; 4 School<br />
of Optometry and Vision Science, University of<br />
New South Wales, Sydney, NSW, Australia; 5 Vision<br />
Cooperative Research Centre, Sydney, NSW,<br />
Australia *CR<br />
4270 — B0307 Age-related Stiffening of<br />
Human Lens Measured by In Vivo Brillouin<br />
Microscopy. Sebastien Besner 1, 2 , G. Scarcelli 1, 2 , R.<br />
Pineda 3 , S. H. Yun 1, 2 . 1 Department of Dermatology,<br />
Harvard Medical School, Boston, MA; 2 Wellman<br />
Center for Photomedicine, Massachusetts<br />
General Hospital, Boston, MA; 3 Department<br />
of Ophthalmology, Massachusetts Eye and Ear<br />
Infirmary, Boston, MA *CR<br />
4271 — B0308 Effect of Temperature on<br />
Lens Power, Anterior and Posterior Surface<br />
Lens Curvatures and Force during Simulated<br />
Accommodation in Cynomolgus Monkeys. Jean-<br />
Marie A. Parel 1, 3 , B. M. Maceo 1, 2 , C. J. Rowaan 1 ,<br />
F. Manns 1, 2 , E. Arrieta 1 . 1 Ophthalmic Biophysics<br />
Center, Bascom Palmer Eye Institute, Univ. of<br />
Miami Miller School of Medicine, Miami, FL;<br />
2<br />
Biomedical Optics and Laser Laboratory, Dept of<br />
Biomedical Engineering, College of Engineering,<br />
University of Miami, Miami, FL; 3 Vision<br />
Cooperative Research Centre, Sydney, NSW,<br />
Australia *CR<br />
4272 — B0309 Lens Spherical Aberration<br />
Changes in Cynomolgus Monkeys during<br />
Simulated Accommodation in a Lens Stretcher.<br />
Bianca M. Maceo 1, 2 , F. Manns 1, 2 , A. de Castro 3 , S.<br />
Uhlhorn 1 , E. Arrieta 1 , S. Marcos 3 , J. A. Parel 1, 4 .<br />
1<br />
Ophthalmic Biophysics Center, Bascom Palmer<br />
Eye Institute, Miami, FL; 2 Biomedical Optics<br />
and Laser Laboratory, Department of Biomedical<br />
Engineering, University of Miami College of<br />
Engineering, Coral Gables, FL; 3 Instituto de Óptica,<br />
Consejo Superior de Investigaciones Científicas,<br />
Madrid, Spain; 4 Vision Cooperative Research<br />
Centre, Sydney, NSW, Australia *CR<br />
4273 — B0310 Comparison between in vivo<br />
and in vitro age-related loss of accommodation in<br />
rhesus monkeys. Mark Wendt, A. Glasser. College<br />
of Optometry, University of Houston, Houston, TX<br />
4274 — B0311 Age-related loss of<br />
accommodation in rhesus monkeys is associated<br />
with an age-related increase in lens stiffness.<br />
Adrian Glasser, M. Wendt. College of Optometry,<br />
University of Houston, Houston, TX<br />
4275 — B0312 Dynamic wavefront<br />
measurement of accommodation and pupil area<br />
in response to electric stimulation of ciliary<br />
nerve in cats. Suguru Miyagawa 1, 2 , T. Mihashi 2, 4 ,<br />
Y. Hirohara 1, 2 , A. Takada 1 , T. Endo 2 , H. Kanda 2 ,<br />
T. Miyoshi 3 , T. Fujikado 2 . 1 Optical Engineering<br />
Laboratory, Topcon Corporation, Itabashi-Ku,<br />
Japan; 2 Dept of Applied Visual Science, Osaka<br />
University Graduate School of Medicine, Suita,<br />
Japan; 3 Integrative Physiology, Osaka University<br />
Graduate School of Medicine, Suita, Japan;<br />
4<br />
Innovative Research Initiatives, Tokyo Institute of<br />
Technology, Yokohama, Japan *CR<br />
4276 — B0313 Macular function contributes<br />
to the near vision performance in the patients<br />
with monofocal intraocular lens: a functional<br />
Multifocal ERG study. Xialin Liu, Y. Ni, C. He, L.<br />
Wang, Y. Liu. Zhongshan Ophthalmic Center, Sun<br />
Yat-sen University, Guangzhou, China<br />
4277 — B0314 Changes in Add Power for Near<br />
Vision after Laser in Situ Keratomileusis for<br />
Presbyopic High Myopia. Yukari Tsuneyoshi 1, 3 , K.<br />
Negishi 1 , M. Yoshida 1 , M. Saiki 1 , N. Kato 1 , I. Toda 2 ,<br />
K. Tsubota 1 . 1 Ophthalmology, Keio University<br />
School of medicine, Tokyo, Japan; 2 Ophthalmology,<br />
Minamiaoyama Eye Clinic, Tokyo, Japan;<br />
3<br />
Ophthalmology, Tachikawa Hospital, Tachikawa,<br />
Japan *CR<br />
4278 — B0315 Subsurface Femto-Laser<br />
Photodisruption in the Sclera for the Creation<br />
of Presbyopic Implant Tunnels. Aghapi<br />
Mordovanakis 1, 2 , L. Baitch 3 . 1 Biomedical<br />
Engineering, University of Michigan, Ann<br />
Arbor, MI; 2 Center for Ultrafast Optical Science,<br />
University of Michigan, Ann Arbor, MI; 3 Research,<br />
Refocus Group, Dallas, TX *CR<br />
4279 — B0316 Electro-optic lens for correction<br />
of presbyopia. Guoqiang Li, T. F. Mauger. Depts<br />
of Ophthal and Vis Sci and ECE, Ohio State<br />
University, Columbus, OH *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
282
<strong>Wednesday</strong> – Posters – 4280 – 4301<br />
4280 — B0317 Tolerance to astigmatism<br />
with a small aperture corneal inlay. Abhiram<br />
S. Vilupuru 1 , J. Tabernero 2 , P. Artal 2 . 1 R&D,<br />
AcuFocus, Inc, Irvine, CA; 2 Universidad de Murcia,<br />
Murcia, Spain *CR<br />
4281 — B0318 Distribution of Achromatizing<br />
Pupil Positions and First Purkinje Reflections<br />
in a Normal Population. Silvestre Manzanera 1 ,<br />
J. Tabernero 1 , A. Benito 1 , A. S. Vilupuru 2 , P. M.<br />
Prieto 1 , P. Artal 1 . 1 Laboratorio de Optica, University<br />
of Murcia, Murcia, Spain; 2 R&D, AcuFocus, Irvine,<br />
CA *CR<br />
4282 — B0319 Visual Simulation of Retinal<br />
Images with Various Designs of Pinhole Contact<br />
Lenses using Ray Tracing Software. Kazuno<br />
Negishi 1 , Y. Nishi 1 , K. Ohnuma 2 , K. Tsubota 1 .<br />
1<br />
Department of Ophthalmology, Keio Univ School<br />
of Medicine, Shinjuku-Ku, Japan; 2 Graduate School<br />
of Engineering, Chiba Univesity, Chiba, Japan *CR<br />
4283 — B0320 Visual Simulation of Retinal<br />
Images with Various Designs of Pinhole<br />
Contact Lenses. Yasuyo Nishi, K. Negishi, K.<br />
Watanabe, Y. Hidaka, H. Torii, M. Saiki, K.<br />
Tsubota. Ophthalmology, Keio University School of<br />
Medicine, Tokyo, Japan *CR<br />
Exhibit Hall C0022-C0045<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Physiology/Pharmacology / Cornea<br />
418 Antibiotics and Corneal Disease<br />
Moderator: Haydee E. Bazan<br />
4284 — C0022 The use of predatory<br />
prokaryotes to control human ocular pathogens.<br />
Robert M. Shanks 1 , K. To 2 , N. A. Stella 1 , K. M.<br />
Brothers 1 , R. P. Kowalski 1 , E. G. Romanowski 1 ,<br />
D. E. Kadouri 2 . 1 Ophthalmology, University of<br />
Pittsburgh, Pittsburgh, PA; 2 Oral Biology, UMDNJ,<br />
Newark, NJ *CR<br />
4285 — C0023 Susceptibility of<br />
Stenotrophomonasmaltophilia to Antibiotics<br />
and Contact Lens Multipurpose Solutions. Keizo<br />
Watanabe 1, 2 , H. Zhu 2 , R. Bandara 2 , S. Higaki 1 ,<br />
M. Fukuda 1 , Y. Shimomura 1 , M. D. Willcox 2 , B. A.<br />
Holden 1 . 1 Ophthalmology, Kinki University Faculty<br />
of Medicine, Osakasayama, Japan; 2 Brien Holden<br />
Vision Institute, Sydney, NSW, Australia *CR<br />
4286 — C0024 A Comparison of Prophylactic<br />
Antibacterial Efficacy of Besifloxacin 0.6% versus<br />
Moxifloacin 0.5% at 1 hour and 3 days Prior to<br />
Phacoemulsification. Frank A. Bucci. Bucci Laser<br />
Vision Institute, Wilkes-Barre, PA *CR, f<br />
4287 — C0025 Cytotoxicities of various<br />
ophthalmic antimicrobial solutions in SV40-<br />
immortalized human corneal epithelial cells. Jae<br />
Lim Chung 1 , S. Song 1 , B. Kim 1 , J. H. Lee 2 , K. Seo 3 .<br />
1<br />
Konyang University Kim’s Eye Hospital, Seoul,<br />
Republic of Korea; 2 Myunggok Eye Research<br />
Institute, Konyang University, Seoul, Republic<br />
of Korea; 3 Shinchon Severance Hospital, Yonsei<br />
University, Seoul, Republic of Korea<br />
4288 — C0026 The In Vitro Activity of<br />
Tigecycline for Clinically Relevant Ocular<br />
Pathogens. Regis P. Kowalski, T. Kowalski,<br />
E. G. Romanowski, R. M. Shanks, L. Raju.<br />
Ophthalmology/Microbiology, Univ of Pittsburgh,<br />
Pittsburgh, PA *CR<br />
4289 — C0027 Tear Osmolarity in Pediatric<br />
Patients with Cystic Fibrosis. Livio Giulio Marco<br />
Franco 1 , V. De Grande 1 , S. Stella 1 , M. Reibaldi 1 ,<br />
E. Lionetti 2 , C. Franzonello 2 , S. Leonardi 2 , C.<br />
Gagliano 1 , A. Russo 1 , M. La Rosa 2 . 1 Institute of<br />
Ophthalmology, University of Catania, Catania,<br />
Italy; 2 Department of Pediatrics, University of<br />
Catania, Catania, Italy<br />
4290 — C0028 The Pharmacokinetics and<br />
Aqueous Humor Penetration of Besifloxacin<br />
0.6% and Moxifloxacin 0.5% in Patients<br />
Undergoing Cataract Surgery. Ruth Evans, F. A.<br />
Bucci. Bucci Laser Vision Institute, Wilkes Barre,<br />
PA *CR, f<br />
4291 — C0029 Ocular Pharmacokinetics,<br />
Safety and Efficacy of Intracameral Moxifloxacin<br />
0.5% Solution in a Rabbit Model. Yonca Akova 1, 2 ,<br />
L. Asena 2 , M. T. Göktas 5 , A. Bozkurt 5 , U. Yasar 5 ,<br />
G. Karabay 4 , E. Demiralay 3 . 1 Ophthalmology,<br />
Bayindir Kavaklidere Hospital, Ankara, Turkey;<br />
2<br />
Ophthalmology, Baskent University Faculty of<br />
Medicine, Ankara, Turkey; 3 Pathology, Baskent<br />
University Faculty of Medicine, Ankara, Turkey;<br />
4<br />
Histology, Baskent University Faculty of Medicine,<br />
Ankara, Turkey; 5 Pharmacology, Hacettepe<br />
University Faculty of Medicine, Ankara, Turkey<br />
4292 — C0030 High affinity LPS-binding<br />
branched peptides display synergistic<br />
activity with other antibiotics. Rajamani<br />
Lakshminarayanan 1, 2 , S. Liu 1, 2 , R. W. Beuerman 1, 2 .<br />
1<br />
Singapore Eye Research Institute, Singapore,<br />
Singapore; 2 SRP Iin Neuroscience and Behavioral<br />
Disorders, Duke-NUS Graduate Medical School,<br />
Singapore, Singapore *CR<br />
4293 — C0031 The Comparison of Topical<br />
RPX-978 (an Ophthalmic Formulation of<br />
Tigecycline) to Topical Vancomycin in a MRSA<br />
Rabbit Keratitis Model. Eric G. Romanowski, K.<br />
A. Yates, K. E. O’Connor, F. S. Mah, L. Raju, R. M.<br />
Shanks, R. P. Kowalski. The Charles T. Campbell<br />
Laboratory, UPMC Eye Center, University of<br />
Pittsburgh, Pittsburgh, PA *CR<br />
4294 — C0032 The Monthly Eye Drop:<br />
Development of a Long-term, Noninvasive<br />
Glaucoma Treatment System. Morgan V.<br />
Fedorchak 1, 2 , A. Cugini 1 , J. S. Schuman 1, 3 , S. R.<br />
Little 1, 2 . 1 University of Pittsburgh, Pittsburgh, PA;<br />
2<br />
McGowan Institute for Regenerative Medicine,<br />
Pittsburgh, PA; 3 UPMC Eye Center, Pittsburgh, PA<br />
*CR<br />
4295 — C0033 Chronic alcohol consumption<br />
and corneal pathologies: the role of aldehyde<br />
dehydrogenases. Naseem Ansari 1, 2 , M. Zhang 1 ,<br />
C. Wang 1 , J. Papaconstantinou 1 , V. Vasiliou 3 , B.<br />
Kaphalia 4 . 1 Biochemistry and Molecular Biology,<br />
University of Texas Medical Branch, Galveston,<br />
TX; 2 Ophthalmology & Visual Science, University<br />
of Texas Medical Branch, Galveston, TX;<br />
3<br />
Pharmaceutical Sciences, University of Colorado,<br />
Aurora, CO; 4 Pathology, University of Texas<br />
Medical Branch, Galveston, TX<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
283<br />
4296 — C0034 Small non-hydrophobic,<br />
cationic peptide with in vitro and in vivo efficacy<br />
against Gram negative bacteria. Roger W.<br />
Beuerman 1 , S. Liu 2 , R. Lakshminarayanan 3 , J. Li 4 ,<br />
B. Yang 5 . 1 Singapore Eye Research Inst, Singapore,<br />
Singapore; 2 Singapore Eye Research Institute,<br />
Singapore, Singapore; 3 Singapore Eye Research<br />
Institute, Singapore, Singapore; 4 Singapore<br />
Eye Research Institute, Singapore, Singapore;<br />
5<br />
Singapore Eye Research Institute, Singapore,<br />
Singapore *CR<br />
4297 — C0035 Molecular Design of Novel<br />
Membrane Targeting Antimicrobials with<br />
Improved Membrane Selectivity Using Natural<br />
Compound as a Scaffold. Shouping Liu 1, 2 , H.<br />
Zou 1 , J. Koh 1 , J. Li 3 , R. Lakshminarayanan 1, 2 , R.<br />
W. Beuerman 1, 2 . 1 Singapore Eye Research Institute,<br />
Singapore, Singapore; 2 Duke-NUS Medical School,<br />
SRP Neuroscience and Behavioural Disorders,<br />
Singapore 169857, Singapore, Singapore;<br />
3<br />
Bioinformatics Institute, Singapore 138671,<br />
Singapore, Singapore *CR<br />
4298 — C0036 In vitro analysis of the effect<br />
of steroid in combination with antimicrobial on<br />
co-cultures of bacteria and fungi isolated from<br />
keratitis. Herlinda Mejia-Lopez 1 , L. Y. Martínez-<br />
López 2 , A. Clinent-Flores 1 , A. V. Rodríguez-Tovar 2 ,<br />
L. A. Bautista-Hernández 1 , V. M. Bautista de<br />
Lucio 1 , M. A. Martínez-Rivera 2 . 1 Research Unit,<br />
Inst of Ophthal “Conde de Valenciana”, Mexico<br />
City, Mexico; 2 Laboratory of Medical Mycology,<br />
Department of Microbiology, National School of<br />
Biological Sciences, Instituto Politécnico Nacional,<br />
México, Mexico<br />
4299 — C0037 Iontophoresis transcorneal<br />
delivery technique for transepithelial corneal<br />
collagen crosslinking with riboflavin in a<br />
rabbit model. Vincent J. Soler 1, 2 , M. Cassagne 1, 2 ,<br />
C. Laurent 3 , A. Galinier 4 , P. R. Fournie 1, 2 , S.<br />
Galiacy 1 , P. Roy 5 , F. J. Malecaze 1, 2 . 1 UMRS 563,<br />
CPTP, Universite Paul Sabatier, Toulouse, France;<br />
2<br />
Ophthalmology, Toulouse Purpan Hospital,<br />
Toulouse, France; 3 Laboratory of Pathology,<br />
Toulouse Purpan Hospital, Toulouse, France;<br />
4<br />
Department of Biochemistry, Toulouse Rangueil<br />
Hospital, Toulouse, France; 5 Hexamed, Paris,<br />
France *CR<br />
4300 — C0038 Comparative Analysis<br />
of In Vitro Biocompatibility Assays of<br />
Polyhexamethylene Biguanide Disinfecting<br />
Contact Lens Multi-Purpose Solutions. Mercedes<br />
Salvador-Silva 1 , L. C. Huang 1 , J. Cook 2 . 1 Biology<br />
R&D, Abbott Medical Optics (AMO), Santa Ana,<br />
CA; 2 Corneal Product Development R&D, Abbott<br />
Medical Optics (AMO), Santa Ana, CA *CR<br />
4301 — C0039 Benzalkonium Chloride<br />
Stimulation of THP-1 Differentiated<br />
Macrophages in Vitro. Sylvain Michee 1, 2 , F.<br />
Brignole-Baudouin 2 , L. Riancho 2 , W. H. Rostene 2 ,<br />
C. Baudouin 1, 2 , A. Labbe 1, 2 . 1 department 3, CHNO<br />
des 15-20, Paris, France; 2 UMRS 968, vision<br />
institute, PARIS, France<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am
4302 – 4321 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
4302 — C0040 Delayed corneal wound<br />
healing resulting from the administration<br />
of fluoroquinolone antibacterial ophthalmic<br />
solutions and its causes. Masamichi Fukuda, Y.<br />
Seki, Y. Kurihara, S. Enta, N. Shibata, K. Hagiwara,<br />
H. Osada, S. Shibata, E. Kubo, H. Sasaki.<br />
Ophthalmology, Kanazawa Medical University,<br />
Uchinada, Japan<br />
4303 — C0041 Penetration of Eye Drop<br />
Solutions of Fluoroquinolones into the Cornea<br />
and Anterior Chamber of Human Enucleated<br />
Eyes. Sidney J. Sousa, G. C. Mendonça.<br />
Ophthalmology, Univ of Sao Paulo-Sch of Med,<br />
Ribeirao Preto, Brazil<br />
4304 — C0042 To evaluate the efficacy of<br />
corneal collagen crosslinking in fungal corneal<br />
ulcers. Shah Nawaz, P. K. Maharana, N. Sharma,<br />
R. B. Vajpayee. Opthalmology, R.P.Centre, AIIMS,<br />
New Delhi, India<br />
4305 — C0043 Improvement of post-cataract<br />
dry eye by 0.05% cyanocobalamine plus 0.5%<br />
taurine and 0.5% long-chained hyaluronic acid.<br />
Federico Solignani 1 , M. Zurria 2 , M. Rolando 1,<br />
3<br />
. 1 Ophthalmology Dept - Ocular surface disease<br />
research center, University of Genoa, Genoa, Italy;<br />
2<br />
Medical Dept, Alfa Intes Ind Ter Spl srl, Casoria,<br />
Italy; 3 Is.Pre Oftalmica, Genoa, Italy *CR<br />
4306 — C0044 Title: Susceptibility Profiles<br />
in Infectious Keratitis as an Aid in Antibiotic<br />
Selection. Mark L. Hill, D. A. Friedman, E. Cooper,<br />
J. Parker. Ophthalmology, UAB, Homewood, AL<br />
4307 — C0045 Photodynamic antimicrobial<br />
chemotherapy for methicillin-resistant<br />
Staphylococcus aureus -in vitro, biofilm, and ex<br />
vivo bovine keratitis model. Hsiao-sang Chu 1 , F.<br />
Hu 1 , C. Chen 2, 3 . 1 Department of Ophthlamology,<br />
National Taiwan University Hospital, Taipei,<br />
Taiwan; 2 Center for Optoelectronic Biomedicine,<br />
College of Medicine, National Taiwan University,<br />
Taipei, Taiwan; 3 Institute of Microbiology and<br />
Biochemistry, College of Life Science, National<br />
Taiwan University, Taipei, Taiwan<br />
Exhibit Hall C0046-C0100<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Cornea<br />
419 Dry Eye and Lacrimal Gland IV<br />
Moderator: Benjamin D. Sullivan<br />
4308 — C0046 Tear specific potential protein<br />
biomarker identification by 2D-DIGE based<br />
proteomics in Dry eye syndrome associated<br />
with Rheumatoid Arthritis. Narayanasamy<br />
Angayarkanni 1 , S. Venkata Aluru 2 , U. Tatu 3 , S.<br />
Agarwal 4 , B. Srinivasan 5 , G. Krishnan Iyer 6 , S.<br />
M. Rajappa 7 , U. Vetrivel 8 , P. Padmanabhan 9 .<br />
1<br />
Biochemistry and Cell Biology, Vision Research<br />
Foundation, Chennai, India; 2 Biochemistry<br />
and Cell Biology, Vision Research Foundation,<br />
Chennai, India; 3 Biochemistry Dept, Indian<br />
Institute of Science, Bangalore, India; 4 Ocular<br />
Surface Clinic, Medical Research Foundation,<br />
Chennai, India; 5 Ocular Surface Clinic, Medical<br />
Research Foundation, Chennai, India; 6 Ocular<br />
Surface Clinic, Medical Research Foundation,<br />
Chennai, India; 7 Cerebrovascular and Vasculitis<br />
Research Foundation, Chennai, India; 8 Centre<br />
for Bioinformatics, Vision Research Foundation,<br />
Chennai, India; 9 Cornea Services, Medical Research<br />
Foundation, Chennai, India<br />
4309 — C0047 The Correlation of Muc-16 as<br />
compared to Dry Eye Clinical Endpoints in Dry<br />
Eye and Normal Subjects. Michael Watson, K. J.<br />
Lane, A. Whitlock, G. W. Ousler. Ora, Inc., Andover,<br />
MA *CR<br />
4310 — C0048 The Use of Soluble Muc-16<br />
(CA-125) as a Clinically Relevant Biomarker and<br />
Endpoint in a Mouse Model of Dry Eye. Jennifer<br />
Brackett, L. Belen, K. Violette, A. Whitlock. Ora,<br />
Inc., Andover, MA *CR<br />
4311 — C0049 Megalin and Cubilin Levels are<br />
Altered in Tear-Producing Glands of Vitamin D<br />
Receptor Null Mice. Xiaowen Lu, M. A. Watsky.<br />
Department of Physiology, University of Tennessee<br />
Health Science Center, Memphis, TN<br />
4312 — C0050 Changes in corneal nerve<br />
morphology and epithelial wound healing<br />
after prolonged ocular dryness induced by<br />
lacrimal gland ablation. Kamila Mizerska 1 , N.<br />
Cuenca 2 , C. Luna 1 , S. Quirce 1 , L. Fernandez-<br />
Sanchez 2 , I. Kovacs 3 , M. Acosta 1 , C. Belmonte 1 , J.<br />
Gallar 1 . 1 Instituto de Neurociencias, Universidad<br />
Miguel Hernandez-CSIC, San Juan de Alicante,<br />
Spain; 2 Departamento de Fisiología, Genética y<br />
Microbiología, Universidad de Alicante, Alicante,<br />
Spain; 3 Department of Ophthalmology, Semmelweis<br />
University, Budapest, Hungary *CR<br />
4313 — C0051 Isolation and characterization<br />
of progenitor cells from intact rabbit lacrimal<br />
gland. Hong He 1 , G. Sun 1 , H. Lin 1 , M. A. Shatos 2 ,<br />
D. A. Dartt 2 , S. C. Yiu 1, 3 . 1 Wilmer Eye Institute,<br />
Baltimore, MD; 2 Shepens Eye Research Institute,<br />
Boston, MA; 3 King Khaled Eye Specialist Hospital,<br />
Riyadh, Saudi Arabia<br />
4314 — C0052 Alterations of Tear Functions<br />
and Ocular Surface Epithelial Differentiation in<br />
the SOD-1 Knock- out Mouse. Murat Dogru 1, 2 , T.<br />
Kojima 2, 1 , T. Nagata 2, 1 , A. Igarashi 1, 2 , K. Higa 1, 2 ,<br />
Y. Satake 1 , S. Shimazaki 1 , S. Takahiko 3 , K. Tsubota 2,<br />
1<br />
, J. Shimazaki 1 . 1 Ophthalmology, Tokyo Dental<br />
College, Ichikawa, Japan; 2 Ophthalmology, Keio<br />
University School of Medicine, Tokyo, Japan;<br />
3<br />
Institute of Aging, Chiba University School of<br />
Medicine, Chiba, Japan *CR<br />
4315 — C0053 L-carnitine, Erythritol and<br />
Betaine Suppress the Production and Activity<br />
of Matrix Metalloproteinases in Primary<br />
Human Corneal Epithelial Cells Exposed to<br />
Hyperosmotic Stress. Ruzhi Deng 1, 2 , Z. Su 1, 2 , J.<br />
Lin 1 , X. Hua 1 , D. Li 1 , S. C. Pflugfelder 1 . 1 Department<br />
of Ophthalmology, Baylor College of Medicine,<br />
Houston, TX; 2 Optometry and Ophthalmology,<br />
Wenzhou Medical College, Wenzhou, China *CR<br />
4316 — C0054 Suppressive effects of<br />
17β-estradiol on immortalized human<br />
meibomian gland epithelial cells. Wendy R. Kam,<br />
D. A. Sullivan. Schepens Eye Research Institute,<br />
Massachusetts Eye and Ear, Harvard Medical<br />
School, Boston, MA *CR<br />
4317 — C0055 Impact of azithromycin on<br />
lipid accumulation in immortalized human<br />
meibomian gland epithelial cells. Yang Liu, W.<br />
R. Kam, J. Ding, D. A. Sullivan. Schepens Eye<br />
Research Institute, Massachusetts Eye and Ear,<br />
Harvard Medical School, Boston, MA *CR<br />
4318 — C0056 A Comparative Evaluation of<br />
Lipid-based Formulations for Dry-Eye Therapy<br />
using a Corneal Epithelial Cell Desiccation<br />
Model and Physicochemical Measurements.<br />
Paramita Sarkar, Z. Marlowe, A. Walsh, B. Glass,<br />
T. Kleiber, M. E. Cavet, K. L. Harrington, S. Davio.<br />
R&D, Bausch & Lomb, Rochester, NY *CR<br />
4319 — C0057 Early Clinical Development<br />
of EBI-005, a Potent Interleukin-1 (IL-1)<br />
Receptor-1 (R1) Blocker for Topical Ocular<br />
Treatment of Dry Eye Disease (DED). Michael H.<br />
Goldstein 1, 2 , G. Zarbis-Papastoitsis 2 , K. Golden 2 ,<br />
S. Chowdhury 2 , C. Wheeler 2 , G. N. Foulks 3 ,<br />
J. T. Kovalchin 2 , J. Agahigian 2 , E. S. Furfine 2 .<br />
1<br />
Ophthalmology, New England Eye Center,<br />
Boston, MA; 2 Eleven Biotherapeutics, Cambridge,<br />
MA; 3 Ophthalmology, University of Louisville,<br />
Louisville, KY *CR, f<br />
4320 — C0058 Preclinical Development of EBI-<br />
005: a Potent Interleukin-1 (IL-1) Receptor-1<br />
(R1) Blocker for Topical Ocular Administration<br />
was Safe in GLP Toxicology Studies and Active<br />
in a Mouse Model of Dry Eye Disease (DED).<br />
Eric S. Furfine 1 , K. Collins 1 , D. Escobar 3 , C. Li 2 , P.<br />
A. Lowden 1 , A. Masci 1 , J. Milling 1 , K. Tenneson 2 ,<br />
G. Wolfe 4 , J. T. Kovalchin 1 . 1 R&D, Eleven<br />
Biotherapeutics, Cambridge, MA; 2 Charles River<br />
Laboratories, Senneville, QC, Canada; 3 Intertek,<br />
San Diego, CA; 4 Gary Wolfe Toxicology LLC,<br />
Herndon, VA *CR<br />
4321 — C0059 Soft steroid topical treatment<br />
for moderate to severe dry eye: pulse vs tapered<br />
therapy. Edoardo Villani, C. Pirondini, F. Viola, R.<br />
Ratiglia. UO Oculistica, Univ of Milan Fnd IRCCS<br />
Ca’ Granda OMP, Milan, Italy<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
284
<strong>Wednesday</strong> – Posters – 4322 – 4345<br />
4322 — C0060 Comparison of Three<br />
Commercially Available Tear Substitutes<br />
Designed for Evaporative Dry Eye Treatment.<br />
Charles G. Connor, R. A. Ottenbreit, L. K.<br />
Schroeder, J. C. Rabin, S. Narayanan. Rosenberg<br />
School of Optometry, University of the Incarnate<br />
Word, San Antonio, TX<br />
4323 — C0061 Plasmacytoid Dendritic Cells<br />
are the Primary Source of IFN-α During the<br />
Immunopathogenesis of Desiccating Stress-<br />
Induced Dry Eye Disease. Michael E. Stern 1 , C.<br />
S. Schaumburg 1 , J. Gao 1 , A. M. Ratanapinta 1 , V.<br />
L. Calder 2 , L. A. Wheeler 1 , J. Y. Niederkorn 3 , S.<br />
C. Pflugfelder 4 , B. Beutler 5 , A. N. Theofilopoulos 6 .<br />
1<br />
Biological Sciences, Allergan, Inc, Irvine, CA;<br />
2<br />
Ophthalmology, University College London,<br />
London, United Kingdom; 3 Ophthalmology,<br />
University of Texas Southwestern Medical School,<br />
Dallas, TX; 4 Ophthalmology, Baylor University<br />
College of Medicine, Houston, TX; 5 Center for<br />
the Genetics of Host Defense, University of<br />
Texas Southwestern Medical School, Dallas,<br />
TX; 6 Immunology & Microbial Science, Scripps<br />
Research Institute, La Jolla, CA *CR<br />
4324 — C0062 Analysis of Tear Inflammatory<br />
Mediators: A comparison of Microarray and<br />
Luminex In Differing Subject Groups. Karen<br />
Dionne, K. K. Nichols, A. M. McDermott, R. L.<br />
Redfern, J. J. Nichols. College of Optometry,<br />
University of Houston, Houston, TX *CR<br />
4325 — C0063 Tear film cytokine analyses<br />
using a novel electrochemiluminescent array<br />
technique. Lakshman N. Subbaraman, M.<br />
Thangavelu, D. J. McCanna, L. W. Jones. CCLR,<br />
School of Optometry, University of Waterloo,<br />
Waterloo, ON, Canada *CR<br />
4326 — C0064 Secretory Group Two A<br />
Phospholipase (sPLA2) Inhibition Decreases<br />
Corneal Superficial Punctate Keratitis (SPK) in<br />
Dry Eye Mice. Yi Wei, P. Li, J. Zou, S. P. Epstein,<br />
N. Gadaria-Rathod, P. A. Asbell. Ophthalmology,<br />
Mount Sinai School of Med, New York, NY *CR<br />
4327 — C0065 New recombinant hyaluronic<br />
acid for eye care and ophthalmic drug delivery.<br />
Birgit Lundskov Fuhlendorff, K. Schwach-<br />
Abdellaoui, F. Longin, C. Eenschooten. Novozymes<br />
Biopharma DKA/S, Bagsvaerd, Denmark *CR<br />
4328 — C0066 Preliminary Studies Of<br />
Liposomal Formulation Containing An<br />
Omega-3 Fatty Acid For Dry Eye Therapy.<br />
Marta Vicario de la Torre 1 , O. Avelino Cruz 1 ,<br />
M. Caballo Gonzalez 1 , B. de las Heras 2 , J. M.<br />
Benitez-del-Castillo 3 , R. Herrero-Vanrell 1 , I. T.<br />
Molina-Martínez 1 . 1 Pharmacy and Pharmaceutical<br />
Technology, Faculty of Pharmacy, Complutense<br />
University, Madrid, Spain; 2 Pharmacology, Faculty<br />
of Pharmacy, Complutense University, Madrid,<br />
Spain; 3 Unidad Superficie e Inflamación Ocular,<br />
Instituto de Investigacaión Sanitaria, Hospital<br />
Clínico San Carlos, Madrid, Spain<br />
4329 — C0067 Clinical Comparison of Lipidbased<br />
and Aqueous Lubricant Eye drops. Peter<br />
A. Simmons, C. Carlisle, G. Shi, J. G. Vehige.<br />
Clinical Research, Allergan, Inc, Irvine, CA *CR, f<br />
4330 — C0068 Autologous Serum Eye Drop is<br />
safe and Effective for Treatment of Dry Eyes in<br />
Graft-versus-host Disease. Amir Azari, M. Rezaei<br />
Kanavi, H. Potter, P. Hematti. Ophthalmology,<br />
University of Wisconsin, Madison, WI<br />
4331 — C0069 Ocular Surface Disease<br />
Characteristics in Patients with Ocular<br />
Graft-versus-Host Disease (GVHD). Hasanain<br />
Shikari 1, 2 , U. S. Saboo 1, 2 , R. Dana 1, 2 . 1 Cornea and<br />
Refractive Surgery, Massachusetts Eye and Ear<br />
Infirmary, Harvard Medical School, Boston, MA;<br />
2<br />
Schepens Eye Research Institute, Harvard Medical<br />
School, Boston, MA *CR<br />
4332 — C0070 Relationships among Tear Film<br />
Stability, Tear Osmolarity, Corneal Staining<br />
History, and Dryness Symptoms. Thao N. Yeh 1 , N.<br />
Tran 1 , A. D. Graham 1 , H. M. Green 2 , M. C. Lin 1, 2 .<br />
1<br />
Clinical Research Center, School of Optometry,<br />
University of California, Berkeley, Berkeley, CA;<br />
2<br />
School of Optometry, University of California,<br />
Berkeley, Berkeley, CA *CR<br />
4333 — C0071 Handheld Tear Film Lipid<br />
Layer Thickness and Non Invasive Tear Break<br />
Up Time Assessment Tool. Igor Petricek.<br />
Ophthalmology, Clinical Hospital Zagreb, Zagreb,<br />
Croatia<br />
4334 — C0072 Does the Phenol Red Thread<br />
test and the Schirmer test measure the same<br />
thing? J. Peter Gierow, S. Andersson. School of<br />
Natural Science, Linnaeus University, Kalmar,<br />
Sweden<br />
4335 — C0073 Limbal capillary perfusion and<br />
blood flow velocity as a potential biomarker for<br />
evaluating dry eye. Jianhua Wang 1 , H. Jiang 1 ,<br />
A. Tao 1, 2 , D. DeBuc 1 , Y. Shao 2, 1 , J. Zhong 3, 1 , S.<br />
Pineda 1 . 1 Ophthalmology, Bascom Palmer Eye Inst<br />
Lib, Miami, FL; 2 Ophthalmology and Optometry,<br />
School of Ophthalmology and Optometry, Wenzhou<br />
Medical College, Wenzhou, China; 3 Ophthalmology,<br />
Hangzhou First People’s Hospital, Hangzhou, China<br />
*CR<br />
4336 — C0074 Real World Analytical<br />
Performance of the TearLab Osmolarity System<br />
with an Enhanced Temperature Sensor. Benjamin<br />
D. Sullivan, S. G. Zmina, M. G. Zmina, M. S. Berg.<br />
TearLab Corp, San Diego, CA *CR<br />
4337 — C0075 Evaluation of the Validity of the<br />
Diagnostic Criteria for Dry Eye in Japan Using<br />
Subjective Symptoms: Osaka Study. Norihiko<br />
Yokoi 1 , M. Uchino 2 , Y. Uchino 2 , M. Dogru 2 , M.<br />
Kawashima 2 , A. Komuro 1 , Y. Sonomura 1 , H. Kato 1 ,<br />
K. Tsubota 2 , S. Kinoshita 1 . 1 Ophthalmology, Kyoto<br />
Prefectural University of Medicine, Kyoto, Japan;<br />
2<br />
Ophthalmology, Keio University School of<br />
Medicine, Tokyo, Japan *CR<br />
4338 — C0076 Progression of Ocular Findings<br />
(PROOF) Study of the Natural History of<br />
Dry Eye: Study Design and Baseline Patient<br />
Characteristics. Peter J. McDonnell 1 , S.<br />
Pflugfelder 2 , R. M. Schiffman 3 , D. R. Hardten 4 ,<br />
M. E. Stern 3 , T. Conway 3 , D. A. Hollander 3 .<br />
1<br />
Ophthalmology, Johns Hopkins Wilmer Eye Inst,<br />
Baltimore, MD; 2 Baylor College of Medicine,<br />
Houston, TX; 3 Allergan, Inc., Irvine, CA;<br />
4<br />
Minnesota Eye Consultants, Minneapolis, MN<br />
*CR, f<br />
4339 — C0077 Prevalence of dry eye subtypes<br />
and severity of evaporative dry eye using<br />
objective tests. Milton M. Hom 1 , J. T. Kwan 2 .<br />
1<br />
Private Practice, Azusa, CA; 2 Southern California<br />
College of Optometry, Fullerton, CA *CR<br />
4340 — C0078 Relating Improvements in<br />
Signs and Symptoms to Duration of Dry Eye<br />
Disease (DED) after Treatment with MIM-D3<br />
Ophthalmic Solutions. Karen Meerovitch 1, 3 ,<br />
T. Lama 1 , D. A. Schaumberg 2, 4 . 1 Mimetogen<br />
Pharmaceuticals, Montreal, QC, Canada; 2 Division<br />
of Preventive Medicine, Brigham & Women’s<br />
Hospital, Harvard Medical School, Boston, MA;<br />
3<br />
Department of Pharmacology and Therapeutics,<br />
McGill University, Montreal, QC, Canada;<br />
4<br />
Department of Ophthalmology and Visual<br />
Sciences, University of Utah School of Medicine,<br />
Salt Lake City, UT *CR, f<br />
4341 — C0079 Automated Detection and<br />
Enumeration of Corneal Superficial Punctate<br />
Keratitis. John D. Rodriguez 1 , P. Johnston 1 , K. J.<br />
Lane 1 , G. W. Ousler 2 . 1 R & D, Ora, Inc., Andover,<br />
MA; 2 Ora, Inc., Andover, MA *CR<br />
4342 — C0080 Ocular Surface Disease<br />
prevalence in Glaucoma patients in a High<br />
Referral Ophthalmology Center in Mexico City.<br />
Nallely Ramos-Betancourt 1 , J. D. Martinez 1 , F.<br />
Beltran 1 , J. Ozorno-Zarate 1 , C. G. Isida Llerandi 2 ,<br />
J. Jimenez-Roman 2 , F. Gil Carrasco 2 , M. Ramirez 1 ,<br />
E. Hernandez-Quintela 1 . 1 Cornea, Asociacion<br />
Para Evitar la Ceguera, Mexico City, Mexico;<br />
2<br />
Glaucoma, Asociación Para Evitar la Ceguera en<br />
México, Mexico City, Mexico<br />
4343 — C0081 High CAE Responders Show<br />
Greater Improvement in Signs and Symptoms of<br />
Dry Eye after Treatment with MIM-D3. George<br />
W. Ousler 1 , K. Meerovitch 2 . 1 Ora, Inc., Andover,<br />
MA; 2 Mimetogen Pharmaceuticals, Montreal, QC,<br />
Canada *CR, f<br />
4344 — C0082 Dietary DHA Abrogate Intrinsic<br />
Sex-Specific Differences in Lacrimal Gland Lipid<br />
Mediator Circuits during Dry Eye. Kyle M. Hu, S.<br />
B. Wang, E. Lu, P. J. Salveson, Y. Gao, K. Gronert.<br />
Vision Science, University of California Berkeley,<br />
Berkeley, CA<br />
4345 — C0083 Analysis of Electrolyte<br />
Composition of Precorneal Tear Film in Normal<br />
Dogs and Horses and its Comparative Values in<br />
Serum and Plasma. Gil Ben-Shlomo, L. N. Taylor.<br />
Veterinary Clinical Sciences, College of Veterinary<br />
Medicine, Iowa State University, Ames, IA<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
285
4346 – 4369 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
4346 — C0084 Decreased Tear Production<br />
in Dogs Following Phacoemulsification. R<br />
D. Whitley 1 , H. E. Visser 2 , K. L. Tofflemire 1 , E.<br />
M. Whitley 3 , R. A. Allbaugh 1 , G. Ben-Shlomo 1 .<br />
1<br />
Veterinary Clinical Sciences, Iowa State University,<br />
Ames, IA; 2 University of Georgia, Athens, GA;<br />
3<br />
Veterinary Pathology, Iowa State University, Ames,<br />
IA<br />
4347 — C0085 Impact of dry eye on reading<br />
in a population based sample of the elderly:<br />
the Salisbury Eye Evaluation. Suzanne W. van<br />
Landingham, S. K. West, E. K. Akpek, B. E. Munoz,<br />
P. Y. Ramulu. Wilmer Eye Institute, Johns Hopkins<br />
University, Baltimore, MD *CR<br />
4348 — C0086 Tear film osmolarity in rosacea<br />
patients. Sabah Judith 1 , M. J. Mannis 1 , B. Durbin-<br />
Johnson 2 , S. Azadmanesh Samimi 3 . 1 Ophthalmology,<br />
UC Davis Health System, Sacramento, CA;<br />
2<br />
Department of Public Health Sciences, UC<br />
Davis, Davis, CA; 3 UC Davis School of Medicine,<br />
Sacramento, CA<br />
4349 — C0087 The Severity of Dry Eye with<br />
Computer Usage and Serum Lipid Levels. Laura<br />
A. Norris, Z. B. Martindale, T. V. Mai-Tran, A. Z.<br />
Chuang, R. W. Yee. Ophthalmology, The University<br />
of Texas Health Science Center at Houston,<br />
Houston, TX *CR<br />
4350 — C0088 Royal jelly prevents lacrimal<br />
hypofunction in Rat Visual Display Terminal<br />
Users Model. Toshihiro Imada, S. Nakamura,<br />
R. Hisamura, K. Tsubota. Ophthalmology, Keio<br />
university, Shinjyukuku, Japan *CR<br />
4351 — C0089 Development of a Chinese<br />
version of the Ocular Comfort Index:<br />
preliminary validation findings. Cecilia Chao 1 , B.<br />
Golebiowski 1 , D. Y. Cui 2 , F. Stapleton 1 . 1 School of<br />
Optometry and Vision Science, The University of<br />
New South Wales, Sydney, NSW, Australia; 2 Brien<br />
Holden Vision Institute, The University of New<br />
South Wales, Sydney, NSW, Australia *CR<br />
4352 — C0090 Clinical Research of Using<br />
Oculus Keratograph for Observing the Location<br />
of First Tear Film Break-up Point. Dan Wu,<br />
J. Hong, J. Xu. EENT hospital of Fudan Uni.,<br />
Shanghai, China<br />
4353 — C0091 Allgrove Syndrome: complex<br />
eye involvement and first evaluation by laser<br />
scanning confocal microscopy. Angelica Dipinto 1 ,<br />
P. Fogagnolo 2 , D. Allegrini 1 , M. Digiuni 1 , L.<br />
Migliavacca 1 , C. Pierrottet 1 , L. Ottobelli 1 , O.<br />
Oneta 1 , L. M. Rossetti 1 . 1 Eye Clinic, San Paolo<br />
Hospital, Milan, Italy; 2 G.B. Bietti Foundation<br />
IRCCS, Rome, Italy<br />
4354 — C0092 How Does Increasing Ocular<br />
Surface Stimulation Affect Blinking? Ziwei Wu 1 ,<br />
C. G. Begley 1 , P. Situ 1 , A. J. Winkeler 1 , J. Zhang 1 ,<br />
T. L. Simpson 2 . 1 Optometry, Indiana University,<br />
Bloomington, IN; 2 Optometry and Vision Science,<br />
University of Waterloo, Waterloo, ON, Canada *CR<br />
4355 — C0093 Do Tear Film Thinning Rates<br />
Vary Locally? Adam J. Winkeler 1 , C. G. Begley 1 ,<br />
R. J. Braun 2 , R. Welch 1 . 1 School of Optometry,<br />
Indiana University, Bloomington, IN; 2 Mathematics,<br />
University of Delaware, Newark, DE *CR<br />
4356 — C0094 Longitudinal Mixed Effect<br />
OSDI Model in a Select Dry Eye Patient<br />
Population after Acupuncture Treatment.<br />
Vanessa Bowlin 1 , S. S. Samudre 1 , D. K. Dhaliwal 2 .<br />
1<br />
Clinical Research, Eastern Virginia Eye Institute,<br />
Chesapeake, VA; 2 School of Medicine, University<br />
of Pittsburgh, Pittsburgh, VA *CR<br />
4357 — C0095 The relationship of depression<br />
and anxiety with dry eye subtypes. Louis<br />
Tong 1, 3 , L. Hong 4 , R. Lee 4 , Y. Zhao 4 , S. C. Sung 2 ,<br />
P. P. Chiang 4 . 1 Cornea and External Eye Disease<br />
Service, Singapore National Eye Ctr, Singapore,<br />
Singapore; 2 Office of Clinical Science, Duke-NUS<br />
graduate medical school, Singapore, Singapore;<br />
3<br />
Ophthalmology, Yong Loo Lin School of Medicine,<br />
National University of Singapore, Singapore,<br />
Singapore; 4 Singapore Eye Research Institute,<br />
Singapore, Singapore<br />
4358 — C0096 The effect of tear lipid<br />
biochemistry on tear evaporation rate during<br />
contact lens wear. Athira Rohit 1, 2 , S. H. Brown 3, 1 ,<br />
M. D. Willcox 2, 1 , F. Stapleton 1, 2 . 1 Optometry, Brien<br />
Holden Vision Institute, Sydney, NSW, Australia;<br />
2<br />
Optometry, School of Optometry and Vision<br />
Science, Sydney, NSW, Australia; 3 School of Health<br />
Sciences, University of Wollongong, Wollongong,<br />
NSW, Australia *CR<br />
4359 — C0097 Evaluation of a Modification of<br />
the Brief Pain Inventory (BODI) as a Measure<br />
of Severity of Dry Eye Disease. Maxwell Pistilli 1 ,<br />
E. Peskin 1 , H. S. Brader 1 , P. Dentone 2 , M. G.<br />
Maguire 1 , P. A. Asbell 2 . 1 Ophthalmology, University<br />
of Pennsylvania, Philadelphia, PA; 2 Ophthalmology,<br />
Mount Sinai School of Medicine, New York, NY<br />
*CR<br />
4360 — C0098 Correlations between nonstimulated<br />
tear levels and conjunctival surface<br />
expression of inflammation-related biomarkers<br />
in normal and aqueous-deficient dry eye<br />
patients. Roderick J. Fullard 1 , J. L. Bradley 1 , L.<br />
D. Williams 1 , M. K. Tran 1 , N. M. Guyette 1 , T. P.<br />
Than 2 , P. J. Shin 1 . 1 Vision Sciences, University<br />
of Alabama at Birmingham, Birmingham, AL;<br />
2<br />
Optometry, University of Alabama at Birmingham,<br />
Birmingham, AL<br />
4361 — C0099 Correlations of Signs and<br />
Symptoms in Subjects with Dry Eye. Sunita<br />
Saigal, P. Johnston, L. Smith. Ora, Inc., Andover,<br />
MA *CR<br />
4362 — C0100 Transcultural validation of<br />
the 5-Item Dry Eye Questionnaire (DEQ-5)<br />
for Mexican population. Everardo Hernandez-<br />
Quintela 1, 2 , N. Ramos-Betancourt 1, 2 , J. D.<br />
Martinez 1, 2 , C. Santacruz Valdes 4, 2 , F. Beltran 1, 2 ,<br />
C. Ramírez-Assad 1, 2 , E. M. Mora Juarez 1, 2 ,<br />
A. Babayan 3, 2 . 1 Cornea y Cirugia Refractiva,<br />
Association Para Evitar la Ceguera, Mexico City,<br />
Mexico; 2 Colegio Nacional de Investigacion<br />
en Ciencias Visuales, M<strong>ARVO</strong>, Mexico City,<br />
Mexico; 3 Cornea y Cirugia Refractiva, Hospital<br />
Fundacion Nuestra Señora de la Luz, Mexico City,<br />
Mexico; 4 Cornea y Cirugia Refractiva, Instituto de<br />
Oftalmologia Conde de Valenciana, Mexico City,<br />
Mexico<br />
Exhibit Hall D0001-D0020<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Eye Movements / Strabismus / Amblyopia /<br />
Neuro-Ophthalmology<br />
420 Neuro-Ophthalmology:<br />
Papilledema, Characterization of Rare<br />
Diseases, and Methods of Evaluation<br />
Moderator: Raghu C. Mudumbai<br />
4363 — D0001 Etiologies and visual outcomes<br />
in secondary pediatric intracranial hypertension.<br />
William Rhoades 1, 2 , G. Heidary 2 . 1 Ophthalmology,<br />
Boston University Medical Center, Boston, MA;<br />
2<br />
Ophthalmology, Children’s Hospital Boston,<br />
Boston, MA<br />
4364 — D0002 Changes of Choroidal<br />
Thickness as Measured with Spectral Domain<br />
OCT in Patients with Idiopathic Intracranial<br />
Hypertension after Lowering of Intracranial<br />
Pressure. Berthold Pemp, K. Kircher, A. Reitner,<br />
U. Schmidt-Erfurth. Department of Ophthalmology,<br />
Medical University of Vienna, Vienna, Austria *CR<br />
4365 — D0003 Smoking associated with<br />
cerebrospinal fluid shunt in patients with<br />
idiopathic intracranial hypertension. Fran L.<br />
Wu, M. S. Lee. Department of Ophthalmology and<br />
Visual Neurosciences, University of Minnesota,<br />
Saint Paul, MN<br />
4366 — D0004 Correlation of Change in<br />
Ocular Pulse Amplitude with Change in<br />
Intracranial Pressure after Lumbar Puncture.<br />
Keerthana Bolisetty 1 , C. J. Roberts 2, 3 , A. M.<br />
Mahmoud 2, 3 , M. Okon 3 , S. E. Katz 2, 3 . 1 College of<br />
Medicine, The Ohio State University, Columbus,<br />
OH; 2 Ophthalmology, The Ohio State University,<br />
Columbus, OH; 3 Biomedical Engineering, The Ohio<br />
State University, Columbus, OH *CR<br />
4367 — D0005 Changes in Intracranial<br />
Pressure (ICP) and Ocular Pulse Amplitude<br />
(OPA) in Patients with Idiopathic Intracranial<br />
Hypertension (IIH). Steven E. Katz 1, 2 , A. M.<br />
Mahmoud 1, 2 , M. Okon 2 , K. Bolisetty 3 , R. H.<br />
Small 4, 2 , C. J. Roberts 1, 2 . 1 Ophthalmology, The<br />
Ohio State University, Columbus, OH; 2 Biomedical<br />
Engineering, The Ohio State University, Columbus,<br />
OH; 3 College of Medicine, The Ohio State<br />
University, Columbus, OH; 4 Anesthesiology, The<br />
Ohio State University, Columbus, OH *CR<br />
4368 — D0006 Evaluation of Inner Retinal<br />
Thicknesses in the Macula of Patients with<br />
Chronic Papilledema from Pseudotumor Cerebri<br />
Syndrome Using Frequency Domain OCT.<br />
Clara L. Afonso 1 , A. S. Raza 2 , D. B. Fernandes 1 , D.<br />
C. Hood 2 , M. L. Monteiro 1 . 1 Ophthalmology, FM<br />
USP, São Paulo, Brazil; 2 Psychology, Columbia<br />
University, New York, NY *CR<br />
4369 — D0007 SD-OCT in monitoring<br />
intracranial pressure in patients with CSF<br />
shunts. Ali Torab Parhiz 1 , P. A. Sibony 1 , M. J.<br />
Kupersmith 2 . 1 Ophthalmology, SUNY at Stony<br />
Brook, Stony Brook, NY; 2 Ophthalmology, New<br />
York Eye and Ear Infirmary, New York, NY<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
286
<strong>Wednesday</strong> – Posters – 4370 – 4389<br />
4370 — D0008 Measurement of Retinal Nerve<br />
Fiber Layer Thickness in Eyes with Optic Disc<br />
Swelling by Using Scanning Laser Polarimetry<br />
and Optical Coherence Tomography. Masayuki<br />
Hata, K. Miyamoto, A. Oishi, N. Yoshimura. Kyoto<br />
University Graduate School of Medicine, Kyoto,<br />
Japan *CR<br />
4371 — D0009 Correlation of Peripapillary<br />
Retinal Nerve Fiber Layer Thickness and<br />
Macular Thickness as Measured by Spectral<br />
Domain Optical Coherence Tomography in<br />
Patients with Severe Vision Loss in End Stage<br />
Optic Neuropathy. Joseph P. Sheehan, C. E.<br />
Francis, L. Ding, R. C. Mudumbai. Ophthalmology,<br />
University of Washington, Seattle, WA<br />
4372 — D0010 Teaching Ophthalmoscopy to<br />
Medical Students: The TOTeMS Study. Philip S.<br />
Garza 1 , L. P. Kelly 1 , B. B. Bruce 2 , E. B. Graubart 1 ,<br />
N. J. Newman 3 , V. Biousse 2 . 1 Ophthalmology,<br />
Emory University, Atlanta, GA; 2 Ophthalmology<br />
and Neurology, Emory University, Atlanta, GA;<br />
3<br />
Ophthalmology, Neurology, and Neurological<br />
Surgery, Emory University, Atlanta, GA<br />
4373 — D0011 Evaluation of localization test<br />
under simulated very low vision conditions.<br />
Takao Endo 1 , T. Fujikado 2 , H. Kanda 2 , T.<br />
Morimoto 2 , S. Kitazawa 3 , K. Nishida 1 . 1 Department<br />
of Ophthalmology, Osaka University Graduate<br />
School of Medicine, Osaka city, Japan; 2 Department<br />
of Applied Visual Science, Osaka University<br />
Graduate School of Medicine, Osaka city, Japan;<br />
3<br />
Frontiers Biosciences, Osaka University Graduate<br />
School of Medicine, Osaka city, Japan *CR<br />
4374 — D0012 Pupil Size Dynamics During the<br />
First Minutes of Dark Adaptation While Fixating<br />
on a Target. Boris I. Gramatikov, K. Irsch, D. L.<br />
Guyton. Ophthalmology, Johns Hopkins Wilmer<br />
Eye Institute, Baltimore, MD *CR<br />
4375 — D0013 Effects of Age on the Peripheral<br />
60-4 Test Comparing Stimulus Sizes III, V, and<br />
VI. Jordan Haas 1, 2 , C. K. Doyle 1, 2 , C. A. Johnson 2 ,<br />
M. Wall 1, 2 . 1 Ophthalmology, Iowa City VA<br />
Healthcare System, Iowa City, IA; 2 Ophthalmology<br />
and Visual Sciences, University of Iowa, Carver<br />
College of Medicine, Iowa City, IA *CR<br />
4376 — D0014 A method of assessing global<br />
motion perception in two-year old children<br />
using the optokinetic reflex. Tzu-Ying Yu 1 , R. J.<br />
Jacobs 1 , N. S. Anstice 1 , N. Paudel 1 , J. E. Harding 2 ,<br />
B. Thompson 1 . 1 Optometry and Vision Science,<br />
University of Auckland, Auckland, New Zealand;<br />
2<br />
Liggins Institute, University of Auckland,<br />
Auckland, New Zealand *CR<br />
4377 — D0015 Comparison of Diopsys Pattern<br />
Reversal Visual Evoked Potential Responses and<br />
Grating Acuity Measurements using the Teller<br />
Acuity Card Procedure. Tina K. Green 1 , J. D.<br />
Twelker 1, 2 , T. R. Kramer 1 , D. J. Mercer 3 , C. Ober 4 ,<br />
C. C. Donaldson 1 , H. Miller 1 , J. M. Miller 1, 2 , E.<br />
M. Harvey 1, 2 . 1 Ophthalmology and Vision Science,<br />
University of Arizona, Tucson, AZ; 2 College of<br />
Public Health, University of Arizona, Tucson, AZ;<br />
3<br />
Watching Over Mothers & Babies Foundation,<br />
Tucson, AZ; 4 Save the Cord Foundation, Tucson,<br />
AZ *CR<br />
4378 — D0016 Prospective study on the<br />
contribution of MRI in the analysis of isolated<br />
mydriasis: a new kind of neurovascular conflict.<br />
Fanny Tréchot 1 , M. Braun 2 , V. Cloche 1 , K. Angioi 1 .<br />
1<br />
Department of Ophthalmology, Chu Nancy<br />
Hopitaux De Brabois, Vandoeuvre-les-Nancy,<br />
France; 2 Department of Neuroradiology, Chu Nancy<br />
Hopital CentraL, Nancy, France<br />
4379 — D0017 Sweep-VEP Acuity as a Clinical<br />
Tool in the Diagnosis of Functional Visual Loss.<br />
Paula Y. Sacai, A. Berezovsky, D. M. Rocha, S.<br />
E. Watanabe, J. M. Pereira, N. N. Cavascan,<br />
T. D. Soares, S. R. Salomao. Ophthalmology,<br />
Universidade Federal de São Paulo, São Paulo,<br />
Brazil<br />
4380 — D0018 Visual field defects and retinal<br />
nerve fibre layer thickness measurements<br />
using optical coherence tomography in<br />
migraine patients. Anna Midelfart 1, 2 , H.<br />
Bjurstrøm 5 , S. Sollie 5 , E. Midelfart 3 , S. Midelfart 4 .<br />
1<br />
Ophthalmology, Norwegian Univ of Sci & Tech,<br />
Trondheim, Norway; 2 Ophthalmology, University<br />
Hospital, Trondheim, Norway; 3 Neurology,<br />
Spesialhelsetjenesten, Trondheim, Norway; 4 Public<br />
Health and General Practice, Norwegian University<br />
of Sci and Tech, Trondheim, Norway; 5 Faculty of<br />
Medicine, Norwegian University of Sci and Tech,<br />
Trondheim, Norway<br />
4381 — D0019 Distinctive Clinical Signs<br />
Differentiating Oculopharyngeal Muscular<br />
Dystrophy from Myasthenia Gravis. Jeffrey<br />
Peterson, M. T. Yen, R. Foroozan. Department<br />
of Ophthalmology, Cullen Eye Institute, Baylor<br />
College of Medicine, Houston, TX *CR<br />
4382 — D0020 Ocular Manifestations<br />
and Optic Nerve Changes in Patients with<br />
Amyotrophic Lateral Sclerosis (ALS). Joseph<br />
Simonett, J. Chou, N. Siddique, J. L. Armstrong, A.<br />
A. Fawzi, T. Siddique, N. J. Volpe. Northwestern<br />
University, Chicago, IL *CR<br />
Exhibit Hall D0021-D0066<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Clinical/Epidemiologic Research<br />
421 Eye Care<br />
Moderators: Joshua D. Stein and<br />
Graham E. Trope<br />
4383 — D0021 Screening of Potentially<br />
Blinding Eye Diseases by Vision Technicians at<br />
Rural Vision Centres in Southern India and their<br />
Referral Agreement with an Ophthalmologist.<br />
Uday Addepalli 1 , S. Vasantha 2 , R. C. Khanna 3 , K.<br />
Sannapaneni 3 , V. Kovai 3 . 1 VST Center for Glaucoma<br />
Services, L V Prasad Eye Insititute, Hyderabad,<br />
India; 2 Glaucoma, Sarojini Devi Eye Hospital,<br />
Hyderabad, India; 3 Allen Foster Research Centre<br />
for Community Eye Health, International Centre for<br />
Advancement of Rural Eye care, L V Prasad Eye<br />
Insititute, Hyderabad, India<br />
4384 — D0022 Geographic Variability In The<br />
Age Of First Cataract Surgery And Rate Of<br />
Cataract Surgery Among Persons Living In<br />
Communities Throughout The U.S. Courtney Y.<br />
Kauh, T. S. Blachley, P. R. Lichter, P. P. Lee, J. D.<br />
Stein. Ophthalmology and Visual Sciences, The<br />
University of Michigan, Ann Arbor, MI *CR<br />
4385 — D0023 Power & type II errors in<br />
recently published ophthalmology research.<br />
Zainab Khan, C. Milko, A. K. Kurji, M. Iqbal, D.<br />
Almeida. Ophthalmology, Queen’s University,<br />
Kingston, ON, Canada<br />
4386 — D0024 A Longitudinal Analysis of<br />
1,660 Recipients of Bilateral Laser Peripheral<br />
Iridotomies to Determine Subsequent Need for<br />
Cataract Surgery and Additional Interventions<br />
for Glaucoma. Sharmini Balakrishnan, T.<br />
S. Blachley, J. Weizer, P. P. Lee, J. D. Stein.<br />
Ophthalmology, University of Michigan Kellogg<br />
Eye Center, Ann Arbor, MI *CR<br />
4387 — D0025 Are Chronic Users of<br />
Chloroquine or Hydroxychloroquine Undergoing<br />
Regular Visits to Eye Providers and Diagnostic<br />
Testing to Check for Maculopathy? Melisa<br />
Nika 1 , T. S. Blachley 1 , P. A. Edwards 2 , P. P.<br />
Lee 1 , J. D. Stein 1 . 1 Ophthalmology and Visual<br />
sciences, Kellogg Eye Center, Ann Arbor, MI;<br />
2<br />
Ophthalmology and Visual sciences, Henry Ford,<br />
Detroit, MI *CR<br />
4388 — D0026 Optimizing cost-effectiveness<br />
analyses of treatments for neovascular agerelated<br />
macular degeneration using real-life<br />
data. Robert P. Finger 1, 2 , A. Hsueh 1 , J. E. Keeffe 1 ,<br />
R. H. Guymer 1 . 1 Ophthalmology, Centre for Eye<br />
Research Australia, Melbourne, VIC, Australia;<br />
2<br />
Ophthalmology, University of Bonn, Bonn,<br />
Germany *CR<br />
4389 — D0027 Comparison of Resource<br />
Consumption in Penetrating versus Endothelial<br />
Keratoplasty from 2009-2010. Duna Raoof-<br />
Daneshvar, R. M. Shtein, T. S. Blachley, M. A.<br />
Woodward, S. I. Mian, A. Sugar, J. D. Stein.<br />
Ophthalmology, University of Michigan, Ann<br />
Arbor, MI *CR<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
287
4390 – 4412 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
4390 — D0028 The Sight Loss and Vision<br />
Priority Setting Partnership (SLV-PSP) - initial<br />
survey methods, respondents’ demographics<br />
and preliminary categorisation framework.<br />
Michael Bowen 1, 2 , M. Acton 5 , D. M. Conroy 5 , R.<br />
P. Wormald 10, 3 , A. Lightstone 8, 9 , K. Cowan 7 , C.<br />
Bunce 10, 4 , M. Fenton 6 , K. Bonstein 10 . 1 Research,<br />
College of Optometrists, London, United Kingdom;<br />
2<br />
Psychology, City University London, London,<br />
United Kingdom; 3 Cochrane Eyes and Vision<br />
Group, London School of Hygiene and Tropical<br />
Medicine, London, United Kingdom; 4 Institute<br />
of Ophthalmology, University College London,<br />
London, United Kingdom; 5 Fight for Sight, London,<br />
United Kingdom; 6 UK Database of Uncertainties<br />
about the Effects of Treatments (UK DUETs),<br />
National Institute for Clinical Excellence (NICE),<br />
London, United Kingdom; 7 The James Lind<br />
Alliance, National Institute for Health Research<br />
(NIHR), London, United Kingdom; 8 VISION 2020<br />
UK, London, United Kingdom; 9 Royal National<br />
Institute for Blind People (RNIB), London, United<br />
Kingdom; 10 Biomedical Research Institute at<br />
Moorfields Eye Hospital NHS Foundation Trust and<br />
UCL Institute of Ophthalmology, National Institute<br />
for Health Research, London, United Kingdom *CR<br />
4391 — D0029 Applying Lean Principles<br />
to Clinical and Translational Research in<br />
Ophthalmology. Vesper Williams 1 , P. Summerfelt 1 ,<br />
T. Kaczanowski 1 , K. Packard 1 , D. M. Bishop 1 , M.<br />
Goldberg 1 , A. Dubra 1, 2 , J. Carroll 1, 3 , A. Suneja 4 .<br />
1<br />
Ophthalmology, Medical College of Wisconsin,<br />
Milwaukee, WI; 2 Biophysics, Medical College<br />
of Wisconsin, Milwaukee, WI; 3 Cell Biology,<br />
Neurobiology, and Anatomy, Medical College<br />
of Wisconsin, Milwaukee, WI; 4 FlowOne Lean<br />
Consulting, LLC, Milwaukee, WI *CR<br />
4392 — D0030 Evaluation of Fundamental<br />
Ophthalmology Knowledge among Internal<br />
Medicine and Emergency Department Residents.<br />
Priya Janardhana, M. A. Desai. Boston Medical<br />
Center, Chestnut Hill, MA<br />
4393 — D0031 The Ophthalmology Job<br />
Market In the Aftermath of the Great Recession.<br />
Chukwuemeka C. Nwanze 1 , R. A. Adelman 3, 1 ,<br />
J. Barth 2, 1 . 1 Lab of Computer Science, MGH,<br />
Lab of Computer Science, Chestnut Hill, MA;<br />
2<br />
Ophthalmology Job Center, American Academy of<br />
Ophthalmology, SanFrancisco, CA; 3 Department of<br />
Ophthalmology and Visual Sciences, Yale School of<br />
Medicine, New Haven, CT<br />
4394 — D0032 PROSE treatment for moderate<br />
to severe ocular graft-versus-host disease:<br />
Analysis of utilization rates versus projected<br />
demand across four centers. Ryan Ridges, B.<br />
Beard, D. S. Jacobs. Boston Foundation for Sight,<br />
Needham, MA *CR<br />
4395 — D0033 Ophthalmology Consultation on<br />
Asymptomatic Patients. Ryan K. Wong, J. Huang.<br />
Ophthalmology and Visual Science, Yale University<br />
School of Medicine, New Haven, CT<br />
4396 — D0034 The economic impact of<br />
cataract surgery in a remote Ghanaian village<br />
three years after surgical intervention. John<br />
D. Welling 1 , E. R. Newick 2 , G. C. Tabin 2, 3 .<br />
1<br />
Ophthalmology, The Ohio State University<br />
Havener Eye Institute, Columbus, OH; 2 Himalayan<br />
Cataract Project, Waterbury, VT; 3 Ophthalmology<br />
and Visual Sciences, University of Utah John A.<br />
Moran Eye Center, Salt Lake City, UT<br />
4397 — D0035 Immediately Sequential<br />
Bilateral Cataract Surgery-A Cost-effective<br />
Procedure. Monali Malvankar 1 , W. G. Hodge 1 , R.<br />
Filek 1 , M. Iqbal 2 , M. A. Shakir 1 , M. Malvankar 1 , S.<br />
Chavda 1 , F. F. Si 1 . 1 Ophthalmology, The University<br />
of Western Ontario, London, ON, Canada; 2 Queens<br />
University, Kingston, ON, Canada<br />
4398 — D0036 iPhone applications in<br />
ophthalmology: Current capabilities, limitations<br />
and future directions. Nicholas M. Cheng 1 , R.<br />
Chakrabarti 2, 3 , J. K. Kam 3 . 1 The Royal Melbourne<br />
Hospital, Melbourne, VIC, Australia; 2 Centre for<br />
Eye Research Australia, Melbourne, VIC, Australia;<br />
3<br />
The Royal Victorian Eye and Ear Hospital,<br />
Melbourne, VIC, Australia<br />
4399 — D0037 Activity and epidemiology of a<br />
recently opened ophthalmic emergency center<br />
in a University Hospital. Francois Ameloot 1, 3 ,<br />
N. Agrinier 2 , F. Tréchot 1 , T. Maalouf 1 , K. Angioi 1 .<br />
1<br />
Ophthalmology, University Hospital of Nancy,<br />
Nancy, France; 2 Epidémiologie et Evaluation<br />
Cliniques, University Hospital of Nancy, Nancy,<br />
France; 3 Ophthalmology, CHR Metz, Metz, France<br />
4400 — D0038 Stability of the Relationship<br />
Between Self-Reported Vision Impairment and<br />
Blindness and Medical Care Expenditures Over<br />
Time. Kevin D. Frick, E. Wehler. Health Policy and<br />
Management, Johns Hopkins Bloomberg Sch of<br />
Public Hlth, Baltimore, MD *CR<br />
4401 — D0039 Glaucoma Treatment: A Closer<br />
Look at Non-adherence. Sumir Pandit 1 , T. C.<br />
Chen 2 . 1 Harvard Medical School, Boston, MA;<br />
2<br />
Ophthalmology/Glaucoma Service, Mass Eye and<br />
Ear Infirmary, Boston, MA<br />
4402 — D0040 Predictive Factors for<br />
Incomplete Adherence to Glaucoma<br />
Management amongst Singaporean Chinese.<br />
Reuben C. Foo 1 , H. Chan 2 , E. L. Lamoureux 3, 4 , R.<br />
Wong 2 , S. Ho 4 , G. Rees 3 , T. Aung 1, 4 , S. Perera 1, 4 ,<br />
T. Wong 1, 4 . 1 Singapore National Eye Centre,<br />
Singapore, Singapore; 2 Yong Loo Lin School of<br />
Medicine, Singapore, Singapore; 3 Centre for Eye<br />
Research Australia, University of Melbourne,<br />
Royal Victorian Eye and Ear Hospital, Melbourne,<br />
VIC, Australia; 4 Singapore Eye Research Institute,<br />
Singapore, Singapore *CR<br />
4403 — D0041 Patient Adherence and<br />
Persistence with Topical Ocular Hypotensive<br />
Therapy: a Claims-Based Comparison of<br />
Bimatoprost 0.01% and Travoprost with sofZia.<br />
Joanna Campbell 1 , G. F. Schwartz 2, 3 , B. LaBounty 4 ,<br />
J. W. Kowalski 1 , V. D. Patel 1 . 1 GHOSR, Allergan,<br />
Irvine, CA; 2 Greater Baltimore Medical Center,<br />
Baltimore, MD; 3 Wilmer Eye Institute, Johns<br />
Hopkins University, Baltimore, MD; 4 Principled<br />
Strategies, Inc., Encinitas, CA *CR<br />
4404 — D0042 Identifying requirements for<br />
effective glaucoma electronic health records: a<br />
consensus study. John E. Somner 1 , R. R. Bourne 1 ,<br />
P. Shah 2 , R. Froud 3 . 1 Anglia Ruskin University,<br />
Vision & Eye Research Unit, Cambridge, United<br />
Kingdom; 2 National Institute for Health Research<br />
(NIHR) Biomedical Research Centre (BRC),<br />
Moorfields Eye Hospital NHS Foundation Trust,<br />
London, United Kingdom; 3 Centre for Primary Care<br />
and Public Health, Barts and The London School of<br />
Medicine and Dentistry, London, United Kingdom<br />
*CR<br />
4405 — D0043 Quality of Referral Letters<br />
to a Tertiary Glaucoma Unit and adherence to<br />
Glaucoma Guidelines. Jason Cheng, L. Beltran-<br />
Agullo, G. E. Trope, Y. M. Buys. Ophthalmology &<br />
Vision Sciences, Toronto Western Hospital, Toronto,<br />
ON, Canada *CR<br />
4406 — D0044 The Utility of a Medical Student<br />
Run Glaucoma Screening Program. Mona A.<br />
Kaleem, V. C. Lerebours, J. W. Logan, J. Llano, L.<br />
S. Jones. Department of Ophthalmology, Howard<br />
University Hospital, Washington, DC<br />
4407 — D0045 Opportunistic Glaucoma<br />
Screening in Rural India: Role of Vision Centers.<br />
Mona Khurana, M. A. KADER, R. Ramakrishnan.<br />
Glaucoma, Aravind Eye Hospital, Tirunelveli, India<br />
4408 — D0046 Qualitative Analysis of Web-<br />
Based LASIK Information Sessions. Roni<br />
M. Shtein, P. P. Lee. Ophthalmology, Univ of<br />
Michigan-Kellogg Eye Ctr, Ann Arbor, MI *CR<br />
4409 — D0047 Results of the Appalachian<br />
Vision Outreach Program: Year 2. J V. Odom, R.<br />
Coakley, J. Charlton, S. Morrison. Ophthalmology,<br />
West Virginia Univ Eye Inst, Morgantown, WV<br />
4410 — D0048 Are outcomes in primary<br />
retinal detachment repair related to distance<br />
away from an academic medical center? Kristen<br />
Harris Nwanyanwu, L. M. Niziol, D. C. Musch, D.<br />
N. Zacks. Department of Ophthalmology and Visual<br />
Sciences, University of Michigan, Ann Arbor, MI<br />
*CR<br />
4411 — D0049 Consent For Future Corneal<br />
Transplantation And Eye Research From AMD<br />
Patients In An Ophthalmic Clinic. Meidong<br />
Zhu 1, 2 , J. Chew 1, 3 , P. Georges 2 , C. Petsoglou 1, 2 , A.<br />
A. Chang 1, 3 . 1 SSI, Ophthalmology & Eye Health,<br />
Sydney Eye Hospital Campus, University of<br />
Sydney, Sydney, NSW, Australia; 2 Lions New South<br />
Wales Eye Bank, NSW Organ and Tissue Donation<br />
Service, Sydney, NSW, Australia; 3 Sydney Retina<br />
Clinic & Day Surgery, Sydney, NSW, Australia *CR<br />
4412 — D0050 Objective and subjective<br />
severity of affections observed at emergency<br />
room in ophthalmology. Aurelie Pison 1 , C.<br />
Mehanna 1, 4 , G. Sawiress 2 , R. Mikou 1 , A. Queant 3, 1 ,<br />
A. P. Brezin 3, 1 , J. Bourges 3, 1 . 1 Department of<br />
Ophthalmology, Hotel Dieu/Cochin Hospital,<br />
APHP, Paris, Paris, France; 2 Department of<br />
informatics, Hotel Dieu/Cochin Hospital, APHP,<br />
Paris, Paris, France; 3 Paris Descartes School of<br />
Medicine, Sorbonne Paris Cité University, Paris,<br />
France; 4 Team 17, INSERM, CIC des Cordeliers,<br />
Paris, France *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
288
<strong>Wednesday</strong> – Posters – 4413 – 4430<br />
4413 — D0051 Acceptance, Attitudes and<br />
Beliefs Of Singaporean Chinese Towards<br />
Subconjunctival, Intracameral and Punctal Plug<br />
Methods of Sustained Glaucoma Drug Delivery<br />
Systems. Hiok Hong Chan 1, 2 , T. Wong 1, 3 , E. L.<br />
Lamoureux 3, 4 , S. Perera 1 . 1 Glaucoma, Singapore<br />
National Eye Centre, Singapore, Singapore; 2 Yong<br />
Loo Lin School of Medicine, National of University<br />
of Singapore, Singapore, Singapore; 3 Singapore Eye<br />
Research Institute, Singapore, Singapore; 4 Centre<br />
for Eye Research Australia, Melbourne, VIC,<br />
Australia *CR<br />
4414 — D0052 Electronic Health Record<br />
Systems in Ophthalmology: Impact on Operating<br />
Room Time Requirements for Cataract Surgery.<br />
Daniel C. Tu 1, 2 , D. S. Sanders 2 , S. Read-Brown 2 , A.<br />
S. Brown 2 , D. Choi 3 , T. R. Yackel 4, 5 , M. F. Chiang 2, 4 .<br />
1<br />
Ophthalmology, Portland Veterans Administration<br />
Medical Center, Portland, OR; 2 Casey Eye Institute,<br />
Ophthalmology, Oregon Health & Science<br />
University, Portland, OR; 3 Public Health and<br />
Preventive Medicine, Oregon Health & Science<br />
University, Portland, OR; 4 Medical Informatics,<br />
Oregon Health & Science University, Portland, OR;<br />
5<br />
Clinical Epidemiology, Oregon Health & Science<br />
University, Portland, OR *CR<br />
4415 — D0053 Efficiency improvements using<br />
an ophthalmological Picture Archiving and<br />
Communication System (PACS) in the diagnostic<br />
workflow of an eye hospital. Karsten U. Kortuem,<br />
W. J. Mayer, S. F. Leicht, L. Reznicek, A. Kampik,<br />
M. Kernt. Ophthalmology, Ludwig-Maximilians-<br />
University, Munich, Germany *CR<br />
4416 — D0054 Ambulatory Surgery Center<br />
(ASC) Utilization by three Ophthalmic Subspecialists:<br />
1999-2011. Kamyar Vaziri 1 , A.<br />
A. Moshfeghi 1 , T. Hernandez-Boussard 2 , N.<br />
Fijalkowski 3 , D. M. Moshfeghi 3 . 1 Ophthalmology,<br />
Bascom Palmer Eye Institute, University of Miami<br />
Miller School of Medicine, Miami, FL; 2 Surgery,<br />
Stanford University School of Medicine, Palo Alto,<br />
CA; 3 Ophthalmology, Byers Eye Institute, Horngren<br />
Family Vitreoretinal Center, Stanford University<br />
School of Medicine, Palo Alto, CA *CR<br />
4417 — D0055 Comparison of theoretical<br />
demand for glaucoma eye care by the African-<br />
American population of cook county to the<br />
supply of ophthalmologic manpower as a pilot<br />
study of access to care. Stephen Watson, D.<br />
Pyatetsky. Ophthalmology, Northwestern University<br />
Feinberg School of Medicine, Chicago, IL<br />
4418 — D0056 Trends in Utilization of<br />
Ancillary Testing for Patients with Exudative<br />
Macular Degeneration and Macular Edema<br />
from 2001 to 2009. Eric W. Schneider 1, 2 , P.<br />
Mruthyunjaya 1 , N. Talwar 2 , K. Harris Nwanyanwu 2 ,<br />
B. Nan 3 , J. D. Stein 2 . 1 Ophthalmology, Duke<br />
University, Durham, NC; 2 Ophthalmology and<br />
Visual Sciences, University of Michigan, Ann<br />
Arbor, MI; 3 Biostatistics, University of Michigan,<br />
Ann Arbor, MI *CR<br />
4419 — D0057 Comparing Patient and Public<br />
Preferences for Health States Associated with<br />
Age-Related Macular Degeneration. Thomas<br />
Butt 1 , H. M. Dunbar 1 , S. Morris 2 , S. Orr 3 , G. S.<br />
Rubin 1, 4 . 1 Institute of Ophthalmology, University<br />
College London, London, United Kingdom;<br />
2<br />
Department of Applied Health Research,<br />
University College London, London, United<br />
Kingdom; 3 Department of Civil and Environmental<br />
Engineering, University College London, London,<br />
United Kingdom; 4 NIHR Moorfields Biomedical<br />
Research Centre, London, United Kingdom<br />
4420 — D0058 Provision of Mass Drug<br />
Administration for Trachoma Control: Cost per<br />
gain in coverage. Sheila K. West 1 , H. A. Mkocha 2 ,<br />
B. E. Munoz 1 , K. D. Frick 3 . 1 Ophthalmology, Johns<br />
Hopkins Wilmer Eye Inst, Baltimore, MD; 2 Kongwa<br />
Trachoma Project, Kongwa, United Republic of<br />
Tanzania; 3 Health Services Research Division,<br />
Johns Hopkins University, Baltimore, MD *CR<br />
4421 — D0059 Trachoma Control: A Potential<br />
Field Test for Ocular C. Trachomatis Infection.<br />
Alexander Jenson 1, 2 , L. Dize 3 , H. A. Mkocha 2, 1 , B.<br />
E. Munoz 1, 2 , J. S. Lee 1, 2 , S. K. West 1, 2 . 1 Dana Center<br />
for Preventative Opthamology, The Johns Hopkins<br />
University, Baltimore, MD; 2 Kongwa Trachoma<br />
Project, The Johns Hopkins University, Kongwa,<br />
United Republic of Tanzania; 3 Infectious Disease,<br />
The Johns Hopkins University, Baltimore, MD<br />
4422 — D0060 Compliance with Eye Screening<br />
Guidelines among Newly-Diagnosed Diabetic<br />
Patients without Diabetic Retinopathy. David<br />
J. Lee 1 , P. Rosa 2 , W. J. Feuer 2 , B. L. Lam 2 , J. C.<br />
Schiffman 2 , N. Kumar 1 , A. Morante 2 . 1 Epidemiology<br />
& Public Health, University of Miami, Miami, FL;<br />
2<br />
Bascom Palmer Eye Institute, University of Miami,<br />
Miami, FL *CR<br />
4423 — D0061 Methods of Assessing Provider<br />
Performance for Quality Improvement. Paul<br />
P. Lee 1 , G. McGwin 2 , S. Asrani 1 , W. Rafferty 1 ,<br />
D. Lobach 1 , K. Kimrey 1 . 1 Ophthalmology and<br />
Visual Sciences, University of Michigan, Ann<br />
Arbor, MI; 2 University of Alabama - Birmingham,<br />
Birmingham, AL *CR, f<br />
4424 — D0062 Electronic health record<br />
(EHR) systems in ophthalmology: Impact on<br />
clinical documentation. David S. Sanders 1 , D.<br />
Lattin 1 , D. C. Tu 1, 2 , S. Read-Brown 1 , D. J. Wilson 1 ,<br />
T. S. Hwang 1 , J. C. Morrison 1 , T. R. Yackel 3 , M.<br />
F. Chiang 1, 3 . 1 Ophthalmology, Oregon Health &<br />
Science University, Portland, OR; 2 Ophthalmology<br />
Operative Care Division, Portland VA Medical<br />
Center, Portland, OR; 3 Medical Informatics and<br />
Clinical Epidemiology, Oregon Health & Science<br />
University, Portland, OR *CR<br />
4425 — D0063 Ophthalmologists’ Attitudes<br />
on Implementing an Electronic Health Record<br />
System. Monica M. Michelotti 1 , J. Weizer 1 , T. S.<br />
Blachley 1 , K. Zheng 2 , M. Couper 3 , G. Greenberg 4 ,<br />
S. Kileny 5 , G. Branford 6 , D. A. Hanauer 5 .<br />
1<br />
Ophthalmology, University of Michigan, Ann<br />
Arbor, MI; 2 School of Public Health, University<br />
of Michigan, Ann Arbor, MI; 3 Institute for Social<br />
Research, University of Michigan, Ann Arbor, MI;<br />
4<br />
Family Medicine, University of Michigan, Ann<br />
Arbor, MI; 5 Pediatrics, University of Michigan,<br />
Ann Arbor, MI; 6 Internal Medicine, University of<br />
Michigan, Ann Arbor, MI<br />
4426 — D0064 Implementation of electronic<br />
health record systems in ophthalmology:<br />
impact on clinical volume compared to other<br />
medical fields. Travis Redd 1 , S. Read-Brown 1 , A.<br />
Kitzmiller 1 , T. R. Yackel 2 , D. Choi 3 , M. F. Chiang 2 .<br />
1<br />
Ophthalmology, Casey Eye Institute, Oregon<br />
Health & Science University, Portland, OR;<br />
2<br />
Ophthalmology & Medical Informatics, Casey<br />
Eye Institute, Oregon Health & Science University,<br />
Portland, OR; 3 Public Health & Preventive<br />
Medicine, Oregon Health & Science University,<br />
Portland, OR *CR<br />
4427 — D0065 Physician and patient<br />
perceptions of electronic health record (EHR)<br />
use in a tertiary care ophthalmologic clinic.<br />
Patrick Chan, R. Singh, S. Charvat. Cole Eye<br />
Institute, Cleveland Clinic, Cleveland, OH *CR<br />
4428 — D0066 Critical Review of High<br />
Quality Ophthalmology Educational Web<br />
Resources Targeting Trainees. Milad Modabber 1 ,<br />
S. Arora 2 , K. F. Damji 3 , F. Adatia 4 . 1 Medicine,<br />
McMaster University, Hamilton, ON, Canada;<br />
2<br />
Ophthalmology, University of Alberta, Edmonton,<br />
AB, Canada; 3 Ophthalmology, University of<br />
Alberta, Edmonton, AB, Canada; 4 Ophthalmology,<br />
University of Calgary, Edmonton, AB, Canada<br />
Exhibit Hall D0114-D0126<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Clinical/Epidemiologic Research<br />
422 Ocular Trauma<br />
Moderator: Gerald McGwin<br />
4429 — D0114 Characteristics of eyelid<br />
laceration due to dog bite in children. Mohammad<br />
Ali Sadiq 1, 2 , I. Mantagos 1, 2 . 1 Department of<br />
Ophthalmology, Boston Children’s Hospital,<br />
Boston, MA; 2 Ophthalmology, Harvard Medical<br />
School, Boston, MA<br />
4430 — D0115 Demographic and Clinical<br />
Profile of Ocular Chemical Injuries in Children.<br />
Pooja Bandivadekar, H. Shekhar, N. Sharma, R. B.<br />
Vajpayee. Dr.rajendra prasad Centre, AIIMS, New<br />
Delhi, India<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
289
4431 – 4452 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
4431 — D0116 Motor Vehicle Crash-<br />
Associated Eye Injuries Presenting to United<br />
States Emergency Departments. Grayson W.<br />
Armstrong 1, 2 , A. J. Chen 1, 3 , J. G. Linakis 4, 5 ,<br />
M. J. Mello 2, 5 , P. B. Greenberg 1, 6 . 1 Division of<br />
Ophthalmology, Warren Alpert Med Sch of Brown<br />
Univ, Providence, RI; 2 Department of Community<br />
Health, Warren Alpert Medical School of Brown<br />
University, Providence, RI; 3 Program in Liberal<br />
Medical Education, Brown University, Providence,<br />
RI; 4 Department of Pediatrics, Warren Alpert<br />
Medical School of Brown University, Providence,<br />
RI; 5 Department of Emergency Medicine, Warren<br />
Alpert Medical School of Brown University,<br />
Providence, RI; 6 Section of Ophthalmology,<br />
Providence VA Medical Center, Providence, RI<br />
4432 — D0117 A Ten Year Review of Open<br />
Globe Trauma in Elderly Patients at an Urban<br />
Hospital. Iris Y. Sheng, A. M. Bauza, P. D. Langer,<br />
M. A. Zarbin, N. Bhagat. IOVS, New Jersey<br />
Medical School, Newark, NJ *CR<br />
4433 — D0118 Clinical outcomes of surgicallytreated<br />
trapdoor fractures in the pediatric<br />
population. Kathleen C. Oktavec, S. L. Merbs, M.<br />
Grant. Division of Oculoplastics, The Wilmer Eye<br />
Institute, Baltimore, MD *CR<br />
4434 — D0119 Severe Ocular Trauma In The<br />
Emergency Room. Albert Lin, C. Confait, S. T.<br />
Hoadley, M. Ahmad, C. J. Chen. Ophthalmology,<br />
Univ of Mississippi Med Center, Jackson, MS<br />
4435 — D0120 Outcomes and characteristics<br />
of open-globe injuries with delayed presentation.<br />
Danielle Trief 1, 2 , M. T. Andreoli 3 , A. S. Shah 1, 2 , Y.<br />
Yonekawa 1, 2 , C. M. Andreoli 1, 4 . 1 Ophthalmology,<br />
Mass Eye and Ear Infirmary, Boston, MA;<br />
2<br />
Ophthalmology, Boston Children’s Hospital,<br />
Boston, MA; 3 Ophthalmology, University of<br />
Illinois College of Medicine at Chicago, Chicago,<br />
IL; 4 Ophthalmology, Harvard Vanguard Medical<br />
Associates, Boston, MA<br />
4436 — D0121 Correlation of Ocular Trauma<br />
Score and visual acuity outcomes in combatrelated<br />
traumatic cataracts. Michael P. Smith, M.<br />
Colyer, D. L. Greenburg. Ophthalmology, Walter<br />
Reed Nt’l Military Med Ctr, Bethesda, MD<br />
4437 — D0122 Ocular and adnexal injuries in<br />
patients with all-terrain vehicle accidents in West<br />
Virginia. Evan Newbolt, C. B. Chen, J. Nguyen, J.<br />
Sivak-Callcott, B. D. Ellis, C. M. Bingham. West<br />
Virginia University, Morgantown, WV<br />
4438 — D0123 Characteristics and<br />
Management of Traumatic Eyes with Full<br />
Thickness Corneal Lacerations. Yi C. Lai, A.<br />
M. Bauza, P. D. Langer, S. Guo, D. S. Chu, A. S.<br />
Khouri, R. D. Fechtner, R. E. Turbin, N. Bhagat.<br />
Institute of Ophthalmology and Visual Science,<br />
New Jersey Medical School, Newark, NJ *CR<br />
4439 — D0124 Nail Gun-Induced Open Globe<br />
Injuries: A Ten-Year Retrospective Review.<br />
Avni Shah, A. M. Bauza, A. M. Kolomeyer, P.<br />
D. Langer, M. A. Zarbin, N. Bhagat. Institute of<br />
Ophthalmology and Visual Science, UMDNJ New<br />
Jersey Medical School, Newark, NJ *CR<br />
4440 — D0125 Utilizing HIWA, a Scoring<br />
System of Pediatric Ocular Trauma<br />
Retrospective Reports, Analyzing Existing<br />
Literature and Informing Future Standards.<br />
Andrea Honda 1 , P. Latkany 1 , M. Lorenzo 1 , E. Su 2 .<br />
1<br />
New York Eye and Ear Infirmary, New York, NY;<br />
2<br />
St. Luke’s Roosevelt Hospital, New York, NY<br />
4441 — D0126 Enucleation following Open<br />
Globe Injury. Ananya Anne, A. M. Bauza, P. D.<br />
Langer, R. E. Turbin, M. A. Zarbin, N. Bhagat.<br />
University of Medicine and Dentistry of New<br />
Jersey, Newark, NJ *CR<br />
Exhibit Hall D0182-D0236<br />
<strong>Wednesday</strong>, May 08, 2013 8:30 AM-10:15 AM<br />
Glaucoma<br />
423 Ocular Blood Flow; Surgery and<br />
Wound Healing<br />
Moderators: Leopold Schmetterer and Alon Harris<br />
4442 — D0182 Retinal Nerve Fiber Layer<br />
Thickness is Correlated to Retrobulbar Blood<br />
Flow in Glaucoma Patients of African Descent.<br />
Anne Schroeder 1 , A. Harris 1 , B. A. Siesky 1 , L.<br />
A. Tobe1, N. J. Kim1, A. Amireskandari 1 , B. M.<br />
Marek 1 , L. Racette 1 , G. J. Eckert 2 , A. Tyring 1 .<br />
1<br />
Ophthalmology, Indiana University School<br />
of Medicine, Indianapolis, IN; 2 Division of<br />
Biostatistics, Indiana University School of<br />
Medicine, Indianapolis, IN *CR<br />
4443 — D0183 Changes in Retinal Blood Flow<br />
are Strongly Correlated to Changes in Optic<br />
Nerve Head Morphology in Patients of African<br />
Descent. Leslie A. Tobe 1 , A. Harris 1 , B. A. Siesky 1 ,<br />
L. Racette 1 , D. WuDunn 1 , A. Amireskandari 1 ,<br />
N. J. Kim 1 , A. H. Huck 1 , A. Tyring 1 , M. Zalish 2 .<br />
1<br />
Ophthalmology, Indiana University School of<br />
Medicine, Indianapolis, IN; 2 Ophthalmology,<br />
Kaplan Medical Center, Rehovot, Israel *CR<br />
4444 — D0184 Comparison of Nebulized<br />
dorzolamide/timolol fixed combination<br />
Mist vs Drops on Retrobulbar Blood Flow,<br />
Intraocular Pressure in Glaucoma Patients.<br />
Ruta Barsauskaite 1 , A. Harris 2 , I. Januleviciene 1 ,<br />
L. Siaudvytyte 1 , V. Diliene 1 , B. Siesky 2 . 1 Eye<br />
Clinic, Lithuanian University of Health Sciences,<br />
Kaunas, Lithuania; 2 Eugene and Marilyn Glick Eye<br />
Institute, Indiana University School of Medicine,<br />
Indianapolis, IN *CR, f<br />
4445 — D0185 Ocular Hemodynamic Changes<br />
after Trabeculectomy in Pseudoexfoliative and<br />
Primary Open-Angle Glaucoma. Vaida Diliene 1 ,<br />
A. Harris 2 , I. Januleviciene 1 , L. Siaudvytyte 1 , R.<br />
Barsauskaite 1 , B. Siesky 2 . 1 Eye Clinic, Lithuanian<br />
University of Health ASciences, Kaunas, Lithuania;<br />
2<br />
Eugene and Marilyn Glick Eye Institute, Indiana<br />
University School of Medicine, Indianapolis, IN<br />
*CR, f<br />
4446 — D0186 Systemic Blood Pressure and<br />
Ocular Perfusion Pressure Affect Macular<br />
Thickness in Glaucoma Patients of African<br />
Descent. Brian M. Marek 1 , A. Harris 1 , B. A. Siesky 1 ,<br />
L. A. Tobe 1 , A. Tyring 1 , A. Amireskandari 1 , N. J.<br />
Kim 1 , J. G. Paschall 1 , G. J. Eckert 2 , L. Racette 1 .<br />
1<br />
Ophthalmology, Indiana Univ. Sch. of Medicine,<br />
Indianapolis, IN; 2 Division of Biostatistics, Indiana<br />
Univ. Sch. of Medicine, Indianapolis, IN *CR<br />
4447 — D0187 Retinal and Macular<br />
Morphology is Correlated with Retrobulbar<br />
Vascular Resistance in Diabetic Patients with<br />
Glaucoma. Austin L. Gerber 1 , A. Harris 1 , B. A.<br />
Siesky 1 , G. J. Eckert 3 , I. Januleviciene 2 , N. J. Kim 1 ,<br />
A. Amireskandari 1 , B. M. Marek 1 , L. A. Tobe 1 , A.<br />
H. Huck 1 . 1 Ophthalmology, Indiana Univ School<br />
of Med, Indianapolis, IN; 2 Eye Clinic, Lithuanian<br />
University of Health Sciences, Kaunas, Lithuania;<br />
3<br />
Division of Biostatistics, Indiana Univ School of<br />
Med, Indianapolis, IN *CR<br />
4448 — D0188 Blood pressure induced<br />
dynamic blood flow autoregulation in the optic<br />
nerve head of early experimental glaucoma. Lin<br />
Wang, C. Piper, G. Cull, C. F. Burgoyne. Devers<br />
Eye Institute, Legacy Research Institute, Portland,<br />
OR *CR<br />
4449 — D0189 The NO donor, isorbide-5-<br />
mononitrate alone or combined with timolol,<br />
latanoprost or dorzolamide ameliorates<br />
intraocular pressure and ocular hemodynamic in<br />
an experimental model of glaucoma in rabbits.<br />
Francesco Impagnatiello 1 , B. Giambene 2 , F.<br />
Fabrizi 3 , E. Bastia 1 , F. Galassi 2 , E. Masini 3 . 1 Nicox<br />
Research Institute, Bresso, Milan, Italy; 2 Eye Clinic,<br />
University of Florence, Florence, Italy; 3 Preclinical<br />
and Clinical Pharmacology, University of Florence,<br />
Florence, Italy *CR<br />
4450 — D0190 Effects of diverse Nitric<br />
Oxide donation on ocular hemodynamic and<br />
intraocular pressure in normotensive rabbits.<br />
Elena Bastia 1 , F. Impagnatiello 1 , D. Miglietta 1 ,<br />
B. Giambene 2 , E. Masini 3 , N. Almirante 1 . 1 Nicox<br />
Research Institute, Bresso, Milan, Italy; 2 Eye Clinic,<br />
University of Florence, Florence, Italy; 3 Preclinical<br />
and Clinical Pharmacology, University of Florence,<br />
Florence, Italy *CR<br />
4451 — D0191 Association between waveform<br />
changes in optic nerve head circulation and<br />
retinal nerve fiber layer thickness in normaltension<br />
glaucoma patients compared to healthy<br />
subjects, measured by laser speckle flowgraphy.<br />
Yukihiro Shiga, Y. Yokoyama, T. Asano, S. Maekawa,<br />
S. Tsuda, N. Aizawa, K. Omodaka, M. Ryu, T.<br />
Nakazawa. Ophthalmology, Tohoku University,<br />
Sendai, Japan *CR<br />
4452 — D0192 Analysis of the Correlation<br />
Between Peripapillary Choroidal Thickness<br />
and the Nerve Fiber Layer Damage in Primary<br />
Open Angle Glaucoma Patients. Nimesh Patel 1 , C.<br />
Krishnan 2, 1 . 1 Tufts University School of Medicine,<br />
Boston, MA; 2 New England Eye Care Center,<br />
Boston, MA *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
290
<strong>Wednesday</strong> – Posters – 4453 – 4474<br />
4453 — D0193 Change in intraocular pressure<br />
is a major determinant of retinal vein pulsation<br />
properties. William Morgan 1 , M. Hazelton 2 , B.<br />
Betz-Stablein 2 , P. House 1 , Y. Dao-Yi 1 . 1 Lions Eye<br />
Institute, Nedlands, WA, Australia; 2 Institute<br />
of Fundamental Sciences, Massey University,<br />
Palmerston North, New Zealand *CR, f<br />
4454 — D0194 Nonphysiologic nocturnal<br />
blood pressure dipping in Primary Open Angle<br />
Glaucoma (POAG) and Normal Pressure<br />
Glaucoma (NPG) patients. Karin R. Pillunat, C.<br />
Hermann, O. Furashova, E. Spoerl, L. E. Pillunat.<br />
Dept of Ophthalmology, Univ Clinic Carl Gustav<br />
Carus Dresden, Dresden, Germany f<br />
4455 — D0195 Relation of Spontaneous Retinal<br />
Venous Pulsation and Disc Hemorrhage in<br />
Open Angle Glaucoma. Mijin Kim 1, 2 , T. Kim 1, 2 ,<br />
R. N. Weinreb 3 , E. Lee 1, 2 , J. Seo 4 , K. Park 1 , D.<br />
Kim 1 . 1 Ophthalmology, Seoul National University<br />
Bundang Hospital, Seongnam, Gyeonggi-do,<br />
Republic of Korea; 2 Ophthalmology, Seoul National<br />
University College of Medicine, Seoul, Republic of<br />
Korea; 3 Hamilton Glaucoma Center and Department<br />
of Ophthalmology, University of California San<br />
Diego, La Jolla, CA; 4 Pusan National University<br />
Yangsan Hospital, Yangsan, Republic of Korea *CR<br />
4456 — D0196 Optic Nerve Capillaries Blood<br />
Oxygenation in Normal and Primary Open-<br />
Angle Glaucoma Subjects. Vasile Diaconu, V.<br />
Tran. Ecole D’optometrie, University of Montreal,<br />
Montreal, QC, Canada<br />
4457 — D0197 Reduced Retinal Blood Flow<br />
is Associated with Thinner Retinal Nerve<br />
Fiber Layer in Glaucomatous Eyes with Single<br />
Hemifield Damage. Mitra Sehi 1 , I. Goharian 1 , R.<br />
Konduru 2 , O. Tan 3 , S. Srinivas 2 , S. R. Sadda 2 , D.<br />
Huang 3 , D. S. Greenfield 1 . 1 Ophthalmology, Bascom<br />
Palmer Eye Institute, University of Miami, Palm<br />
Beach Gardens, FL; 2 Ophthalmology, Doheny Eye<br />
Institute, University of Southern California, Los<br />
Angeles, CA; 3 Ophthalmology, Casey Eye Institute,<br />
Oregon Health and Science University, Portland,<br />
OR *CR, f<br />
4458 — D0198 Optic Nerve Head Label-free<br />
Microangiography: OCT-based Correlation<br />
of Microstructure and Microvasculature in<br />
Normal & Open Angle Glaucoma Subjects.<br />
Lin An 1 , P. Li 1 , M. A. Johnstone 2 , R. K. Wang 1, 2 .<br />
1<br />
Bioengineering, University of Washington, Seattle,<br />
WA; 2 Ophthalmology, University of Washington,<br />
Seattle, WA *CR<br />
4459 — D0199 Effect of Cerebrospinal<br />
Fluid Pressure on Central Retinal Artery<br />
Hemodynamics: a Mathematical Model. Lucia<br />
Carichino 1 , G. Guidoboni 1 , A. Amireskandari 2 ,<br />
B. Siesky 2 , A. Harris 2 . 1 Mathematics, Indiana<br />
University Purdue Univ, Indianapolis, IN;<br />
2<br />
Ophthalmology, Indiana University Sch of<br />
Medicine, Indianapolis, IN *CR<br />
4460 — D0200 The effect of anthocyanins<br />
and ginko biloba extract treatment in patients<br />
with open-angle glaucoma depending on<br />
the presence of diabetes mellitus. Yong Woo<br />
Lee 1 , S. Shim 1 , J. Kim 1 , C. Choi 1 , K. Park 2 .<br />
1<br />
Ophthalmology, Sungkyunkwan University School<br />
of Medicine,Kangbuk Samsung Hospital, Seoul,<br />
Republic of Korea; 2 Ophthalmology, Seoul National<br />
University College of Medicine, Seoul, Republic<br />
of Korea<br />
4461 — D0201 A theoretical investigation of<br />
the relationship between intraocular pressure,<br />
cerebrospinal fluid pressure, arterial blood<br />
pressure, blood flow autoregulation and retinal<br />
hemodynamics. Giovanna Guidoboni 1 , A. Harris 2 ,<br />
S. Cassani 1 , L. Carichino 1 , A. Amireskandari 2 , B. A.<br />
Siesky 2 . 1 Mathematics, Indiana University Purdue<br />
Univ, Indianapolis, IN; 2 Ophthalmology, Indiana<br />
University School of Medicine, Indianapolis, IN<br />
*CR<br />
4462 — D0202 Effect of Trabeculectomy on<br />
Retinal Hemodynamics: Mathematical Modeling<br />
of Clinical Data. Simone Cassani 1 , G. Guidoboni 1 ,<br />
I. Januleviciene 3 , L. Carichino 1 , B. Siesky 2 , L. A.<br />
Tobe 2 , A. Amireskandari 2 , A. Harris 2 . 1 Mathematics,<br />
Indiana University Purdue Univ, Indianapolis,<br />
IN; 2 Ophthalmology, Indiana University Sch<br />
of Medicine, Indianapolis, IN; 3 Eye Clinic Of<br />
Lithuanian University of Health Sciences, Kaunas,<br />
Lithuania *CR<br />
4463 — D0203 Effect of intraocular pressure<br />
and arterial blood pressure on oxygen saturation<br />
levels in the retina: a theoretical model. Julia<br />
Arciero 1 , A. Harris 2 , G. Guidoboni 1 . 1 Mathematics,<br />
Indiana Univ-Purdue Univ Indianapolis,<br />
Indianapolis, IN; 2 Ophthalmology, Indiana<br />
University, Indianapolis, IN *CR<br />
4464 — D0204 Retinal Oximetry in Early<br />
Primary Open Angle Glaucoma. Scott D.<br />
Lawrence, P. D. Jani, K. Billow, J. Mwanza, I.<br />
A. Falkenstein. Ophthalmology, Univ of North<br />
Carolina at Chapel Hill, Chapel Hill, NC<br />
4465 — D0205 Optic nerve head basal blood<br />
flow increases early and then progressively<br />
decreases in non-human primate experimental<br />
glaucoma. Grant Cull, C. Piper, C. F. Burgoyne,<br />
L. Wang. Devers Eye Institute, Legacy Research<br />
Institute, Portland, OR *CR<br />
4466 — D0206 Correlation between<br />
papillomacular bundle thickness (PMBT)<br />
and optic nerve blood flow in primary openangle,<br />
including normal-pressure, glaucoma.<br />
Wataru Kobayashi 1 , K. Omodaka 1 , K. Togashi 2 , M.<br />
Ryu 1 , T. Yuasa 2 , T. Nakazawa 1 . 1 Ophthalmology,<br />
Tohoku University, Sendai, Japan; 2 Bio-Systems<br />
Engineering, Yamagata University, Yonezawa,<br />
Japan *CR<br />
4467 — D0207 Optic Nerve Head Morphology<br />
and Retrobulbar Blood Flow; Differences<br />
between Glaucoma Patients with and without<br />
Diabetes. Joshua G. Paschall, A. Harris, B. A.<br />
Siesky, L. A. Tobe, A. Amireskandari, N. J. Kim,<br />
C. R. Yung, B. M. Marek, D. WuDunn, J. Abrams.<br />
Ophthalmology, Indiana University School of<br />
Medicine, Indianapolis, IN *CR<br />
4468 — D0208 Glaucoma Patients with<br />
Diabetes Have Increasing Vascular Resistance<br />
in the Ophthalmic and Central Retinal Arteries<br />
Compared to Glaucoma Patients without<br />
Diabetes. Nathaniel J. Kim, A. Harris, B. A. Siesky,<br />
A. Amireskandari, J. G. Paschall, D. WuDunn,<br />
L. B. Cantor, C. R. Yung, L. A. Tobe, J. Abrams.<br />
Ophthalmology, Indiana University School of<br />
Medicine, Indianapolis, IN *CR<br />
4469 — D0209 Changes in Retinal Blood Flow<br />
Correlate More Strongly with Changes in Optic<br />
Nerve Head Morphology in Glaucoma Patients<br />
with Diabetes Compared to Glaucoma Patients<br />
without Diabetes. Annahita Amireskandari, A.<br />
Harris, B. A. Siesky, N. J. Kim, B. M. Marek, J.<br />
G. Paschall, L. B. Cantor, Y. P. Catoira-Boyle, J.<br />
Abrams, L. A. Tobe. Ophthalmology, Indiana Univ<br />
Sch of Medicine, Northville, MI *CR<br />
4470 — D0210 Systemic Blood Pressure and<br />
Ocular Perfusion Pressure affect Retrobulbar<br />
Blood Flow Differently in Glaucoma Patients<br />
of European and African Descent. Ariel Tyring,<br />
A. Harris, B. A. Siesky, L. Racette, Y. P. Catoira-<br />
Boyle, A. Amireskandari, N. J. Kim, J. G. Paschall,<br />
B. M. Marek, L. A. Tobe. Ophthalmology, Indiana<br />
University School of Medicine, Indianapolis, IN<br />
*CR<br />
4471 — D0211 Retinal Oximetry in Primary<br />
Open-Angle Glaucoma: Differences in Patients<br />
of African and European Descent. Brent A.<br />
Siesky, A. Harris, L. Racette, L. B. Cantor, L. A.<br />
Tobe, Y. P. Catoira-Boyle, C. R. Yung, D. WuDunn,<br />
J. M. Beach. Ophthalmology, Indiana Univ Sch of<br />
Medicine, Zionsville, IN *CR<br />
4472 — D0212 Systemic Blood Pressure and<br />
Ocular Perfusion Pressure Affects Blood Flow<br />
to the Optic Nerve Head in Glaucoma Patients<br />
with Diabetes. Andrew H. Huck 1 , A. Harris 1 , B. A.<br />
Siesky 1 , L. A. Tobe 1 , N. J. Kim 1 , A. Amireskandari 1 ,<br />
B. M. Marek 1 , I. Januleviciene 2 , B. M. Wirostko 3 ,<br />
G. J. Eckert 4 . 1 Ophthalmology, Indiana<br />
University School of Medicine, Indianapolis, IN;<br />
2<br />
Ophthalmology, Lithuanian University of Health<br />
Sciences, Kaunas, Lithuania; 3 Ophthalmology,<br />
University of Utah, Park City, UT; 4 Division<br />
of Biostatistics, Indiana University School of<br />
Medicine, Indianapolis, IN *CR<br />
4473 — D0213 Effects of Rho Kinase<br />
Inhibitor on mRNAs Associated with Glaucoma<br />
Progression in Human Trabecular Meshwork<br />
Cells Following Oxidative Stress. Hideki<br />
Mochizuki, J. Hirata, Y. Kiuchi. Ophthalmology and<br />
Visual Science, Hiroshima University, Hiroshima,<br />
Japan<br />
4474 — D0214 Burden of care associated with<br />
Childhood Glaucoma: 4 year study. Jacey Hanna,<br />
L. Ravindraraj, R. D. Fechtner, A. S. Khouri.<br />
Ophthalmology, The Institute of Ophthalmology<br />
and Visual Science, New Jersey Medical School,<br />
Newark, NJ<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
291
4475 – 4496 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
8:30 am – 10:15 am<br />
4475 — D0215 Evaluation of surface free<br />
energy of Aurolab Aqueous Drainage Implant<br />
(AADI) and its influence on cell adhesion<br />
property, in comparison with Baerveldt Implant.<br />
Chidambaranathan Gowri Priya 1 , K. Sivakumar 2 ,<br />
M. Pillai 3 , S. Krishnadas 4 , R. D. Sriram 5 , V.<br />
Muthukkaruppan 6 . 1 Department of Immunology<br />
and Stem Cell Biology, Aravind Medical Research<br />
Foundation, Dr. G. Venkataswamy Eye Research<br />
Institute, Madurai, India; 2 Polymer Division,<br />
Aurolab, Madurai, India; 3 Glaucoma Clinic,<br />
Aravind Eye Hospital and Postgraduate Institute of<br />
Ophthalmology, Madurai, India; 4 Glaucoma Clinic,<br />
Aravind Eye Hospital and Postgraduate Institute of<br />
Ophthalmology, Madurai, India; 5 Aurolab, Madurai,<br />
India; 6 Department of Immunology and Stem Cell<br />
Biology, Aravind Medical Research Foundation, Dr.<br />
G. Venkataswamy Eye Research Institute, Madurai,<br />
India *CR<br />
4476 — D0216 Targeting specific TGF-β<br />
signaling pathways to prevent bleb fibrosis after<br />
glaucoma drainage device surgery. Christian<br />
K. Vorwerk 1 , V. Sokalskis 2 , A. Zabelyshenskiy 2 , H.<br />
Thieme 1 , L. Choritz 1, 2 . 1 Dept of Ophthalmology,<br />
Otto von Guericke University, Magdeburg,<br />
Germany; 2 Dept of Ophthalmology, University<br />
Medical Center, Mainz, Germany<br />
4477 — D0217 Retrospective study of<br />
congenital glaucoma surgical treatment. Hector<br />
Bello Lopez Portillo, J. Jimenez-Roman, M. Turati-<br />
Acosta, M. García-Huerta, R. Castañeda Diez, F.<br />
Gil Carrasco, C. Isida Llerandi. Asociacion para<br />
Evitar la Ceguera en Mexico, Mexico, Mexico<br />
4478 — D0218 Intraocular Pressure Reduction<br />
of Modified 360-degree Suture Trabeculotomy<br />
in Intent-to-treat Eyes. Daisuke Shiba, T. Ono, N.<br />
Ozeki, K. Yuki, K. Tsubota. Ophthalmology, Keio<br />
University, Shinjuku-ku, Japan *CR<br />
4479 — D0219 Evaluation of Dose Effect<br />
of ALK-5 Inhibitor and Controlled Delivery<br />
with Novel Pentablock Polymer in Glaucoma<br />
Filtration Surgery. Hiroshi Nakamura 1, 2 , J. J.<br />
Dunmire 1 , V. Sutariya 2, 3 , M. Hewit 2 , D. Wehrung 2 ,<br />
S. Patel 4 , A. K. Mitra 4 . 1 Ophthalmology, Summa<br />
Health System, Akron, OH; 2 Pharmaceutical<br />
sciences, Northeast Ohio Medical University,<br />
Rootstown, OH; 3 Pharmaceutical sciences,<br />
University of South Florida, Tampa, FL;<br />
4<br />
Pharmaceutical sciences, University of Missouri-<br />
Kansas City, Kansas City, MO<br />
4480 — D0220 The effect of steroid and matrix<br />
metalloproteinase inhibitor on bleb survival<br />
in an experimental animal model. Alastair<br />
Lockwood 1, 2 , A. Mohamed Ahmed 1, 2 , A. Khalili 1, 2 ,<br />
S. Awwad 1, 2 , G. Sharma 1, 2 , S. Brocchini 1, 2 , P. T.<br />
Khaw 1 . 1 NIHR Moorfields Biomedical Research<br />
Centre, London, United Kingdom; 2 UCL School<br />
of Pharmacy, University College London, London,<br />
United Kingdom *CR<br />
4481 — D0221 Attenuation of Glaucoma<br />
Filtration Surgery-induced Scarring by an<br />
FDA-approved Histone Deacetylase Inhibitor,<br />
Suberoylanilide Hydroxamic Acid (SAHA). Ajay<br />
Sharma, J. W. Brubaker, M. Reyes, J. T. Rodier,<br />
A. Tandon, R. R. Mohan. Mason Eye Institute,<br />
University of Missouri, Columbia, MO<br />
4482 — D0222 Surgical Outcomes of<br />
Augmented MMC Trabeculectomy After<br />
Failed Seton Surgery. Jose A. Paczka 1, 3 , L. A.<br />
Giorgi-Sandoval 2, 3 , M. A. Ramos-Hernandez 1 , J.<br />
Jimenez-Roman 2, 3 , A. Merikansky 2 . 1 Oftalmologia,<br />
University of Guadalajara, Guadalajara, Mexico;<br />
2<br />
Oftalmologia, Asistencia e Investigacion en<br />
Glaucoma, A.C., Guadalajara, Mexico; 3 Glaucoma,<br />
Global Glaucoma Institute, Guadalajara, Mexico<br />
4483 — D0223 Influence of endothelin-1 in<br />
aqueous humor on IOP and filtration surgery<br />
outcome. Lars Choritz 1, 2 , B. Mahmoodi 1 , M.<br />
Machert 1 , N. Pfeiffer 1 , H. Thieme 2 . 1 Ophthalmology,<br />
University Medical Center, Mainz, Germany;<br />
2<br />
Ophthalmology, University Clinic, Otto von<br />
Guericke University, Magdeburg, Germany *CR<br />
4484 — D0224 A New Technique for Glaucoma<br />
Surgery: Scorolli Trabeculectomy. Lucia<br />
Scorolli 1 , E. Meduri 2 , A. De Leo 5 , R. Meduri 3 , E.<br />
Zere 4 , P. Piccaluga 5 , S. Scalinci 1 . 1 Ophthalmology, S<br />
Orsola Malpighi Hospital Bologna, Bologna, Italy;<br />
2<br />
Medical School, University of Sophia, Sophia,<br />
Bulgaria; 3 IE Business School, Madrid, Spain;<br />
4<br />
Ophthalmology, Univesity La Sapienza, Rome,<br />
Italy; 5 Molecular Pahology, University of Bologna,<br />
Bologna, Italy<br />
4485 — D0225 Functional and anatomic<br />
outcomes following endocyclophotocoagulation<br />
(ECP) surgery for neo-vascular glaucoma as<br />
compared to routine glaucoma care. Kyle V.<br />
Marra 1 , S. Wagley 2 , A. F. Omar 3 , J. G. Arroyo 1 .<br />
1<br />
Beth Israel Deaconess Medical Center, Boston,<br />
MA; 2 College of Human Medicine - Michigan<br />
State University, East Lansing, MI; 3 Joslin Diabetes<br />
Center, Boston, MA<br />
4486 — D0226 Efficacy of Catheter Assisted<br />
360° Trabeculotomy in Primary Congenital<br />
Glaucoma (PCG). Erika Wandel 1 , D. Dave 1 , M.<br />
Vora 2 , C. H. Marcus 3 , R. F. Rothman 3 , T. Frempong 1 ,<br />
D. D. Hayes 3 , A. Angelilli 3 , J. B. Serle 1, 3 .<br />
1<br />
Ophthalmology, Mount Sinai Hospital, New York,<br />
NY; 2 Ophthalmology, North Shore-Long Island<br />
Jewish Health System, Manhasset, NY; 3 Glaucoma<br />
Consultants of Long Island, Bethpage, NY *CR<br />
4487 — D0227 Ahmed glaucoma valve FP7<br />
and FP8 in pediatric glaucoma: A randomized<br />
clinical trial. Bruno L. Esporcatte, C. F. Netto,<br />
T. Tanno, L. S. Melo, I. M. Tavares, C. Rolim de<br />
Moura. Glaucoma, Federal University of São Paulo,<br />
São Paulo, Brazil f<br />
4488 — D0228 A model to measure surgical<br />
outflow using a two-tubed experimental<br />
glaucoma drainage device. Craig Ross, D.<br />
Nguyen, S. S. Pandav, Y. Li, J. G. Crowston, M.<br />
A. Coote. Centre for Eye Research Australia,<br />
University of Melbourne, Royal Victorian Eye and<br />
Ear Hospital, East Melbourne, VIC, Australia<br />
4489 — D0229 Comparison of Early Post-<br />
Operative Challenges in P200 Ex-PRESS Shunts<br />
and Conventional Trabeculectomies. Maheen<br />
Haque, B. A. Hughes, J. Tannir, R. Momi, C. Kim.<br />
Kresge Eye Institute/Wayne State University,<br />
Detroit, MI<br />
4490 — D0230 Comparision of surgical<br />
outcomes of Express Shunt and Ahmed Valve<br />
in Neovascular Glaucoma. Huseyin Kadikoy, B.<br />
A. Hughes, J. Tannir, R. Momi. Ophthalmology,<br />
Kresge Eye Institute, Royal Oak, MI<br />
4491 — D0231 A Novel Minimally Invasive<br />
Drainage Implant (the MIDI-Arrow): One-Two<br />
Year Follow Up. Paul F. Palmberg 1 , J. F. Batlle 3 ,<br />
R. Alburquerque 3 , A. Corona-Peralta 3 , I. Riss 4 ,<br />
R. Parrish 1 , E. Arrieta 2 , J. A. Parel 2 . 1 Biophysics<br />
(Ophthalmology), University of Miami, Miami,<br />
FL; 2 Ophthalmology, University of Miami, Miami,<br />
FL; 3 Centro Laser, Santo Domingo, Dominican<br />
Republic; 4 Pole Ophtalmologogique, Clinique<br />
Mutualiste, Pessac, France *CR, f<br />
4492 — D0232 Surgical Outcomes in First<br />
25 Canaloplasties and Impact of Growing<br />
Experience on Complications. Elisabeth P.<br />
Aponte, J. Eisengart. Ophthalmology, Cleveland<br />
Clinic Cole Eye Institute, Cleveland, OH<br />
4493 — D0233 Review of the Success Rate<br />
of an Intraoperative Modified Bleb Revision<br />
Technique. Priya Gupta, K. S. Arora, C. Lee, D.<br />
S. Friedman. Wilmer Eye Institute, Johns Hopkins<br />
Hospital, Baltimore, MD *CR<br />
4494 — D0234 Clinical and Tomographic<br />
Findings in Filtering Blebs Undergoing Digital<br />
Compression. Miriam A. Ramos-Hernandez 2 ,<br />
M. A. Ramos-Hernandez 2 , E. Chavez 2 , L. A.<br />
Giorgi-Sandoval 1 , J. A. Paczka 1, 2 . 1 Asistencia e<br />
Investigacion en Glaucoma, A.C., Guadalajara,<br />
Mexico; 2 Instituto de Oftalmologia y Ciencias<br />
Visuales, Guadalajara, Mexico<br />
4495 — D0235 Cyclodialysis incidence in<br />
anterior segment surgery in an Ophthalmology<br />
Referral Center. Rodrigo Bolanos 1 , A. Navas 3 , E.<br />
O. Graue-Hernández 3 , A. J. Ramirez-Miranda 3 ,<br />
J. Ledesma Gil 2 . 1 Research Unit, Inst of Ophthal<br />
Conde de Valenciana, Mexico City, Mexico;<br />
2<br />
Glaucoma, Instituto de Oftalmologia Conde de<br />
Valenciana, Mexico DF, Mexico; 3 Cornea An<br />
Refractive Surgery, Instituto de Oftalmologia<br />
Conde de Valenciana, Mexico DF, Mexico *CR<br />
4496 — D0236 Optimal administration route<br />
of bevacizumab after glaucoma filtration<br />
surgery. Karolien P. Hollanders 1 , T. Van Bergen 1 ,<br />
D. Sijnave 1 , S. Van de Velde 1 , E. Vandewalle 1 , L.<br />
K. Moons 2 , I. Stalmans 1 . 1 Neuroscience, Lab of<br />
Ophthalmology, KULeuven, Leuven, Belgium;<br />
2<br />
Biology, KULeuven, Leuven, Belgium *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
292
<strong>Wednesday</strong> – Papers/Minisymposium – 4497 – 4508<br />
6B<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Glaucoma<br />
424 Genetics I<br />
Moderators: John H. Fingert and<br />
Andrew J. Lotery<br />
4497 — 11:00 Genome-wide Association Study<br />
and Meta-Analysis of Intraocular Pressure in<br />
Primary Open-Angle Glaucoma Cases and<br />
Controls in the NEIGHBOR, GLAUGEN and<br />
AMD-MMAP Studies. Sayoko E. Moroi 1 , A. B.<br />
Ozel 2 , D. M. Reed 1 , K. E. Branham 1 , M. A. Hauser 3 ,<br />
L. R. Pasquale 4 , J. L. Wiggs 4 , J. E. Richards 1 , J. Z.<br />
Li 2 . 1 Ophthalmology & Visual Sciences, Univ of<br />
Michigan-Kellogg Eye Ctr, Ann Arbor, MI; 2 Human<br />
Genetics, University of Michigan, Ann Arbor, MI;<br />
3<br />
Center for Human Genetics, Duke University<br />
School of Medicine, Durham, NC; 4 Department<br />
of Ophthalmology, Harvard Medical School,<br />
Massachusetts Eye and Ear Infirmary, Boston, MA<br />
*CR<br />
4498 — 11:15 Molecular mechanisms in<br />
Primary Glaucoma: POAG-associated variant<br />
disrupts microRNA regulation of CDKN2B<br />
expression. Terry Gaasterland 1, 2 , A. N. Dubinsky 3 ,<br />
A. R. La Spada 3, 8 , K. Mansouri 4, 10 , K. H. Willert 8, 9 ,<br />
D. E. Gaasterland 5 , M. A. Hauser 6 , L. R. Pasquale 7 ,<br />
J. L. Wiggs 7 , R. N. Weinreb 10 . 1 Institute for Genomic<br />
Medicine, Univ of California San Diego, La Jolla,<br />
CA; 2 Marine Biology Research Division, Univ of<br />
California San Diego, La Jolla, CA; 3 Department of<br />
Pediatrics, Univ of California San Diego, La Jolla,<br />
CA; 4 University of Geneva, Geneva, Switzerland;<br />
5<br />
Ophthalmology, Potomac, MD; 6 Department<br />
of Medicine, Duke University, Durham, NC;<br />
7<br />
Massachusetts Eye and Ear Institute, Harvard,<br />
Cambridge, MA; 8 Cellular and Molecular Medicine;<br />
Neurosciences, Univ of California San Diego, La<br />
Jolla, CA; 9 Sanford Consortium for Regenerative<br />
Medicine, La Jolla, CA; 10 Hamilton Glaucoma<br />
Center, Univ of California San Diego, La Jolla, CA<br />
*CR<br />
4499 — 11:30 Runs of Homozygosity Across<br />
the Whole Genome Suggests two Novel Genes<br />
in Primary Congenital Glaucoma. Subhabrata<br />
Chakrabarti 1 , S. Ganguly 3 , M. Kabra 1 , A. K.<br />
Mandal 2 , S. Senthil 1 , I. Kaur 1 , P. P. Majumder 4, 3 .<br />
1<br />
Brien Holden Eye Research Centre, LV Prasad Eye<br />
Institute, Hyderabad, India; 2 Jasti V Ramanamma<br />
Childrens Eye Care Centre, L V Prasad Eye<br />
Institute, Hyderabad, India; 3 Department of Human<br />
Genetics, Indian Statistical Institute, Kolkata,<br />
India; 4 National Institute of Biomedical Genomics,<br />
Kalyani, India<br />
4500 — 11:45 Genetic factors and pathways<br />
affecting retinal nerve fiber layer thickness.<br />
Cristina Venturini 1, 2 , P. G. Hysi 2 , A. Nag 2 , E.<br />
Yonova 2 , J. Wang 3, 4 , T. Y. Wong 5, 6 , P. R. Healey 4 ,<br />
P. Mitchell 4 , C. J. Hammond 2 , A. C. Viswanathan 7,<br />
8<br />
. 1 Genetics, UCL, Institute of Ophthalmology,<br />
London, United Kingdom; 2 Twin Research &<br />
Epidemiology Research, King’s College London,<br />
London, United Kingdom; 3 Centre for Eye Research<br />
Australia (CERA), Department of Ophthalmology,<br />
University of Melbourne, Melbourne, NSW,<br />
Australia; 4 Department of Ophthalmology,<br />
University of Sydney Centre for Vision Research,<br />
Sydney, NSW, Australia; 5 Epidemiology and<br />
Public Health, National University of Singapore,<br />
Singapore, Singapore; 6 Singapore Eye Research<br />
Institute, Singapore, Singapore; 7 Glaucoma Service,<br />
Moorfield Eye Hospital, London, United Kingdom;<br />
8<br />
NIHR Biomedical Research Centre, Moorfield<br />
Eye Hospital and UCL Institute of Ophthalmology,<br />
London, United Kingdom *CR<br />
4501 — 12:00 The role of SIX6 in primary<br />
open-angle glaucoma. Michael A. Hauser 1, 2 , M.<br />
Ulmer 1 , Y. Liu 3 , E. Davis 3 , N. Katsanis 3 , Y. Liu 1 ,<br />
L. R. Pasquale 4 , J. L. Wiggs 4 , A. E. Ashley-Koch 1 ,<br />
R. Allingham 2 . 1 Medicine, Duke Univ Medical<br />
Center, Durham, NC; 2 Ophthalmology, Duke Univ<br />
Medical Center, Durham, NC; 3 Cell Biology, Duke<br />
University, Durham, NC; 4 Ophthalmology, Harvard<br />
Medical School, Boston, MA *CR<br />
4502 — 12:15 A genome-wide association<br />
study of intra-ocular pressure identifies a<br />
novel association in the gene FAM125B in the<br />
TwinsUK cohort. Abhishek Nag 1 , P. G. Hysi 1 ,<br />
C. Venturini 2, 1 , E. Yonova 1 , K. M. Williams 1 , C.<br />
J. Hammond 1 . 1 Department of Twin Research,<br />
King’s College London, London, United Kingdom;<br />
2<br />
Institute of ophthalmology, University College<br />
London, London, United Kingdom<br />
4503 — 12:30 Identification of further novel<br />
genome wide significant loci for open angle<br />
glaucoma blindness utilizing the Australian<br />
and New Zealand Registry of Advanced<br />
Glaucoma. Jamie E. Craig 1 , A. W. Hewitt 2, 1 ,<br />
S. Graham 3 , P. R. Healey 4 , R. J. Casson 5 , P.<br />
Mitchell 4 , J. Landers 1 , S. MacGregor 6 , D. A.<br />
Mackey 2 , K. P. Burdon 1 . 1 Ophthalmology, Flinders<br />
University, Bedford Park, Adelaide, SA, Australia;<br />
2<br />
Ophthalmology, Lions Eye Institute, Perth, WA,<br />
Australia; 3 Ophthalmology, Macquarie University,<br />
Sydney, NSW, Australia; 4 Ophthalmology,<br />
Sydney University, Sydney, NSW, Australia;<br />
5<br />
Ophthalmology, Adelaide University, Adelaide,<br />
SA, Australia; 6 Queensland Institute of Medical<br />
Research, Brisbane, QLD, Australia *CR<br />
6C<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Retina<br />
425 AMD: Novel and<br />
Combination Therapies<br />
Moderators: Susanne Binder and Pravin U. Dugel<br />
4504 — 11:00 Anti-VEGF Gene Therapy for<br />
Wet AMD: Safety and Tolerability of Subretinal<br />
Delivery in a Phase I/II Clinical Trial. Ian<br />
Constable 1, 2 , C. Pierce 2 , S. K. Somasundaram 2 ,<br />
M. Lai 1, 2 , T. W. Chalberg 3 , M. S. Blumenkranz 4 ,<br />
R. Samulski 5 , E. P. Rakoczy 1, 2 . 1 Centre for<br />
Ophthalmology and Visual Sciences, University<br />
of Western Australia, Perth, WA, Australia; 2 Lions<br />
Eye Institute, Perth, WA, Australia; 3 Avalanche<br />
Biotechnologies, San Francisco, CA; 4 Byers Eye<br />
Institute at Stanford, Palo Alto, CA; 5 Pharmacology<br />
and Gene Therapy Center, University of North<br />
Carolina, Chapel Hill, NC *CR, f<br />
4505 — 11:15 Phase I, Masked, Placebo-<br />
Controlled, Single and Multiple Ascending<br />
Intravenous Dose Studies Evaluating Systemic<br />
and Ocular Safety, Tolerability, and Visual<br />
Acuity Effects of RN6G (PF-04382923) in<br />
Subjects with Dry, Age-Related Macular<br />
Degeneration (ARMD). Brian B. Berger 1 , P.<br />
D. Garzone 2 , I. Gunderson 1 , P. M. Fanning 2 , G.<br />
Wong 2 , K. H. Liao 2 , S. Y. Hua 2 , J. Lin 2 . 1 Retina<br />
Research Center, Austin, TX; 2 Pfizer Inc., South San<br />
Francisco, CA *CR, f<br />
4506 — 11:30 A Phase 2 Double-masked,<br />
Placebo-controlled, Dose Ranging Study of<br />
Emixustat Hydrochloride (ACU-4429) in<br />
Subjects with GA Associated with Dry AMD.<br />
Pravin U. Dugel 1 , R. L. Novack 2 , K. G. Csaky 3 , P.<br />
P. Richmond 4 , D. G. Birch 5 , R. Kubota 6 . 1 Retinal<br />
Consultants of Arizona, Ltd, Phoenix, AZ; 2 Retina-<br />
Vitreous Associates Medical Group, Beverly Hills,<br />
CA, Beverly Hills, CA; 3 Texas Retina Associates,<br />
Dallas, TX, Dallas, TX; 4 Central Florida Retina,<br />
Orlando, FL, Orlando, FL; 5 Retina Foundation of<br />
Southwest, Dallas, TX, Dallas, TX; 6 Acucela Inc.,<br />
Seattle, WA, Seattle, WA *CR, f<br />
4507 — 11:45 Photodynamic Therapy vs<br />
Combination Therapy in Polypoidal Choroidal<br />
Vasculopathy: Changes of Aqueous Vascular<br />
Endothelial Growth Factor. Meeyon Lee 1 , W. Lee 2 .<br />
1<br />
Chung ang University hospital, Seoul, Republic of<br />
Korea; 2 Seoul St. Mary hospital, Seoul, Republic of<br />
Korea *CR, f<br />
4508 — 12:00 Twelve Months Results<br />
Comparing Ranibizumab or Bevacizumab<br />
Treatment in Patients with Neovascular Agerelated<br />
Macular Degeneration(AMD) Multicenter<br />
Anti-VEGF Trial in Austria The Manta Study.<br />
Susanne Binder 1 , I. Krebs 1 , L. Schmetterer 2 .<br />
1<br />
Ophthalmology, Rudolf Foundation Clinic, Vienna,<br />
Austria; 2 Department of Clinical Pharmacology,<br />
Medical University, Vienna, Austria f<br />
<strong>Wednesday</strong> Papers/<br />
Minisymposium<br />
11:00 am – 12:45 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
293
4509 – 4524 – <strong>Wednesday</strong> – Papers/Minisymposium<br />
<strong>Wednesday</strong> Papers/<br />
Minisymposium<br />
11:00 am – 12:45 pm<br />
4509 — 12:15 Long-Term and Lasting<br />
Outcomes of Combination Treatment for<br />
Age-Related Macular Degeneration with<br />
Photodynamic Therapy and Intravitreal<br />
Injection of Anti-Vascular Endothelial Growth<br />
Factor. Colleen M. McLellan, R. Silva-Garcia, K.<br />
W. Small. Molecular Insight Research Foundation,<br />
Glendale, CA *CR<br />
6E<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Retina<br />
426 Macular Disease Other<br />
Than AMD II<br />
Moderators: William F. Mieler and<br />
K. Bailey Freund<br />
4510 — 11:00 Occult Central Serous<br />
Chorioretinopathy. K Bailey Freund 1, 2 , D.<br />
Warrow 3 , R. Gallego-Pinazo 1, 5 , Q. V. Hoang 4 .<br />
1<br />
Ophthalmology, Vitreous Retina Macula<br />
Consultants New York, New York, NY;<br />
2<br />
Ophthalmology, New York University, New<br />
York, NY; 3 Ophthamology, New York Eye and<br />
Ear Infirmary, New York, NY; 4 Ophthalmology,<br />
Columbia University, New York, NY;<br />
5<br />
Ophthalmology, University and Polytechnic<br />
Hospital La Fe, Valencia, Spain *CR<br />
4511 — 11:15 Effect of Somatostatin on the<br />
expression of tight junctions and urokinase<br />
plasminogen activator receptor in human retinal<br />
pigment epithelial cells. Alex Fonollosa 1, 2 , J.<br />
Artaraz 1 , A. Martinez-Berriotxoa 1 , E. Vecino 2 .<br />
1<br />
Ophthalmology, Hospital de Cruces, Portugalete,<br />
Spain; 2 Grupo de Oftalmobiologia Experimental,<br />
Bilbao, Spain<br />
4512 — 11:30 Selective Laser Photocoagulation<br />
of Peripheral Non-perfused Retinal Areas<br />
May Improve the Vision in Patients with<br />
Central Retinal Vein Occlusion Treated with<br />
Ranibizumab. Matus Rehak 1 , A. Franke 2 , P. M.<br />
Wiedemann 1 . 1 Department of Ophthalmology,<br />
University of Leipzig, Leipzig, Germany; 2 Clinical<br />
Trial Centre (ZKS) Leipzig, University of Leipzig,<br />
Leipzig, Germany *CR, f<br />
4513 — 11:45 Macular Bruchs Membrane<br />
Defects and Axial Length: Association with<br />
Gamma Zone and Delta Zone in Peripapillary<br />
Region. Jost B. Jonas 1 , K. Ohno-Matsui 2 ,<br />
R. F. Spaide 3 , L. Holbach 4 , S. Panda-Jonas 1 .<br />
1<br />
Ophthalmology, Medical Faculty Mannheim-<br />
Heidelberg, Mannheim, Germany; 2 Department<br />
of Ophthalmology and Visual Science, Tokyo<br />
Medical and Dental University, Tokyo, Japan;<br />
3<br />
Vitreous-Retina-Macula Consultants of New<br />
York and the LuEsther T. Mertz Retinal Research<br />
Center, Manhattan Eye, Ear, and Throat Hospital,<br />
New York, NY; 4 Department of Ophthalmology,<br />
Friedrich-Alexander University Erlangen-Nürnberg,<br />
Erlangen, Germany *CR<br />
4514 — 12:00 Treatment Experience with<br />
Intravitreal Aflibercept Injection (IAI) After<br />
Switching to PRN Dosing in Patients with<br />
Macular Edema Secondary to Central Retinal<br />
Vein Occlusion (CRVO). David M. Brown 1 , F. G.<br />
Holz 2 . 1 Retina Consultants of Houston, Houston,<br />
TX; 2 Department of Ophthalmology, University of<br />
Bonn, Bonn, Germany *CR, f<br />
4515 — 12:15 Two-Year Results of the<br />
COPERNICUS Study Evaluating Intravitreal<br />
Aflibercept Injection (IAI) for Macular Edema<br />
Secondary to Central Retinal Vein Occlusion<br />
(CRVO). W. Lloyd Clark. Palmetto Retina Center,<br />
West Columbia, SC *CR, f<br />
4516 — 12:30 Eighteen-Month Results of<br />
the GALILEO Study Evaluating Intravitreal<br />
Aflibercept Injection (IAI) for Macular Edema<br />
Secondary to Central Retinal Vein Occlusion<br />
(CRVO). Yuichiro Ogura 1 , J. Korobelnik 2 , J.<br />
Roider 3 , R. Vitti 4 , F. G. Holz 5 , F. Hiemeyer 6 , B.<br />
Stemper 6 , O. Zeitz 6 , R. Sandbrink 6 . 1 Department<br />
of Ophthalmology, Nagoya City University<br />
Medical School, Nagoya, Japan; 2 Department<br />
of Ophthalmology, CHU Bordeaux, Universite<br />
Bordeuax, Bordeaux, France; 3 Department of<br />
Ophthalmology, University Medical Center<br />
Schleswig-Holstein, Kiel, Germany; 4 Regeneron<br />
Pharmaceuticals Inc., Tarrytown, NY; 5 Department<br />
of Ophthalmology, University of Bonn, Bonn,<br />
Germany; 6 Bayer Healthcare, Berlin, Germany<br />
*CR, f<br />
606/607<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Immunology/Microbiology<br />
427 Ocular Immune Responses<br />
Moderators: Holly L. Rosenzweig and<br />
Thomas Langmann<br />
4517 — 11:00 Loss of MicroRNA-124<br />
and MicroRNA-126 expression regulates<br />
inflammatory microglial activation in inherited<br />
retinal degeneration. Thomas Langmann 1, 2 , C.<br />
Moehle 3 , M. Karlstetter 1 , B. H. Weber 2 . 1 Department<br />
of Ophthalmology, University of Cologne, Cologne,<br />
Germany; 2 Institute of Human Genetics, University<br />
of Regensburg, Regensburg, Germany; 3 Center of<br />
Excellence for Fluorescent Bioanalytics, University<br />
of Regensburg, Regensburg, Germany<br />
4518 — 11:15 Mice lacking TNFR1 develop<br />
less angiogenesis during late stage experimental<br />
autoimmune uveoretinitis (EAU). Madeleine<br />
Stimpson 1 , J. Liu 1 , D. A. Copland 1 , T. K. Khera 1 ,<br />
A. D. Dick 1, 2 . 1 Academic Unit of Ophthalmology,<br />
University of Bristol, Bristol, United Kingdom;<br />
2<br />
Cellular and Molecular Medicine, University of<br />
Bristol, Bristol, United Kingdom *CR<br />
4519 — 11:30 Differential effects of TLR-<br />
3 activated RPE on retinal microglia and<br />
blood-derived monocytes. Alexa K. Klettner 1 ,<br />
T. Hamann 1 , S. Wilker 1 , C. Berg 1 , K. Schlüter 1 , R.<br />
Lucius 2 , M. Rolf 2 , J. Roider 1 . 1 Ophthalmology, Univ<br />
of Kiel, Kiel, Univ Medical Center, Kiel, Germany;<br />
2<br />
Anatomy, University of Kiel, Kiel, Germany *CR<br />
4520 — 11:45 Demonstration of Donor T cell<br />
Recruitment and Correlation with Inflammatory<br />
Cytokine Presence in Experimental Ocular<br />
Graft-versus-Host Disease. Samantha Herretes 1 ,<br />
J. C. Murillo 1 , D. Ross 2 , H. Barreras 2 , Y. Tan 1 , A. M.<br />
Saeed 1 , A. Gonzalez 1 , C. Betancurt 1 , R. B. Levy 2 , V.<br />
L. Perez 1, 2 . 1 Ophthalmology, Bascom Palmer Eye<br />
Inst, Univ of Miami, Miami, FL; 2 Immunology and<br />
Microbiology, University of Miami, Miami, FL *CR<br />
4521 — 12:00 Monophasic PDSAg-induced<br />
EAU dominates over relapsing R14-induced<br />
EAU. Ulrike Kaufmann, M. Diedrichs-Möhring,<br />
G. Wildner. Ophthalmology, Clinic of the Ludwig-<br />
Maximilians-University, Munich, Germany<br />
4522 — 12:15 Inhibition of Vascular<br />
Endothelial Growth Factor Ameliorates Ocular<br />
Allergy in the Murine Model. Daniel R. Saban 1 ,<br />
R. Dana 2 , H. Lee 2 , T. Blanco 1 . 1 Ophthalmology,<br />
Duke University School of Medicine, Durham, NC;<br />
2<br />
Ophthalmology, Schepens Eye Res Inst, Mass. Eye<br />
& Ear, Harvard Medical School, Boston, MA *CR<br />
4523 — 12:30 Translational Modeling of<br />
Calpain-5 Vitreoretinopathy Mechanisms<br />
in Mice. Vinit B. Mahajan 1, 2 , K. J. Wert 3 , J. M.<br />
Skeie 1, 2 , S. H. Tsang 4 . 1 Ophthalmology, University<br />
of Iowa, Iowa City, IA; 2 Omics Laboratory,<br />
University of Iowa, Iowa City, IA; 3 Institute of<br />
Human Nutrition, Columbia University, New York,<br />
NY; 4 Ophthalmology, Columbia University, New<br />
York, NY<br />
608<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Anatomy/Pathology<br />
428 Uveal Melanoma: Experimental<br />
Therapeutics<br />
Moderators: Hans Grossniklaus, Sarah E.<br />
Coupland and Arun D. Singh<br />
4524 — 11:00 Microphthalmia-associated<br />
transcription factor (MITF) and Steroid<br />
Receptor Coactivator (SRC)-3 cooperate to<br />
promote proliferation, survival and metabolism<br />
in Gα-mutant uveal melanoma (UM) cells.<br />
Vassiliki Poulaki 1, 2 , S. Chew 3, 4 , B. He 3, 4 , V.<br />
Eedunuri 5 , M. M. Jager 6 , B. W. O’Malley 4 ,<br />
N. Mitsiades 3, 4 . 1 Ophthalmology, Boston VA<br />
Healthcare System, Boston, MA; 2 Ophthalmology,<br />
Boston University, Boston, MA; 3 Medicine,<br />
Baylor College of Medicine, Houston, TX;<br />
4<br />
Molecular and Cellular Biology, Baylor College<br />
of Medicine, Houston, TX; 5 Adrienne Helis Malvin<br />
Medical Research Foundation, New Orleans, LA;<br />
6<br />
Ophthalmology, Leiden University Medical Center,<br />
Leiden, Netherlands<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
294
<strong>Wednesday</strong> – Papers/Minisymposium – 4525 – 4541<br />
4525 — 11:15 Uveal Melanoma Cells Are<br />
Inhibited by AICAR Partially Through<br />
Activation of AMP-Dependent Kinase. Ahmad<br />
Al Moujahed 1 , F. Nicolaou 2 , T. D. Papakostas 1 ,<br />
J. W. Miller 1 , E. S. Gragoudas 1 , D. Vavvas 1 .<br />
1<br />
Ophthalmology, Massachusetts Eye and Ear<br />
Infirmary, Harvard Medical School, Boston, MA;<br />
2<br />
Pediatric Surgery Laboratories, Massachusetts<br />
General Hospital, Boston, MA *CR<br />
4526 — 11:30 SRPK1 Inhibition, As A Way Of<br />
Targeting Pro-Angiogenic VEGF-A Production<br />
In Ocular Tumours. Melissa V. Gammons 1 , S. E.<br />
Coupland 3 , A. D. Dick 2 , D. O. Bates 1 . 1 Department<br />
of Physiology and Pharmacology, University<br />
of Bristol, Bristol, United Kingdom; 2 School of<br />
Clinical Sciences and School of Cellular and<br />
Molecular medicine, University of Bristol, Bristol,<br />
United Kingdom; 3 Department of Molecular and<br />
Clinical Cancer Medicine, University of Liverpool,<br />
Liverpool, United Kingdom *CR<br />
4527 — 11:45 Targeting Uveal Melanoma<br />
Response to Hypoxia. Dudi Shneor 1, 2 , A.<br />
Honigman 2 , J. Pe’er 1 , S. Frenkel 1 . 1 Ophthalmology,<br />
Hadassah-Hebrew University Medical Center,<br />
Jerusalem, Israel; 2 Biochemistry and Molecular<br />
Biology, IMRIC, The Hebrew University-Hadassah<br />
Medical School, Jerusalem, Israel<br />
4528 — 12:00 Efficacy of A Novel Anti-tumor<br />
Agent KCN1 in the Control of Ocular Melanoma<br />
In vitro and In vivo. Qing Zhang 1, 2 , H. Yang 1 ,<br />
S. Kaluz 3 , E. G. Van Meir 3, 4 , H. E. Grossniklaus 1,<br />
5<br />
. 1 Ophthalmology, Emory University School of<br />
Medicine, Atlanta, GA; 2 Ophthalmology, Central<br />
South University Xiangya School of Medicine,<br />
Changsha, China; 3 Neurosurgery, Winship Cancer<br />
Institute, Emory University School of Medicine,<br />
Atlanta, GA; 4 Hematology and Medical Oncology,<br />
Emory University School of Medicine, Atlanta, GA;<br />
5<br />
Pathology, Emory University School of Medicine,<br />
Atlanta, GA *CR<br />
4529 — 12:15 NFkB Inhibition in Uveal<br />
Melanoma - Contrariety of in vitro vs. in vivo<br />
Results. Shahar Frenkel 1 , D. Shneor 2, 1 , J. Pe’er 1 ,<br />
A. Honigman 2 . 1 Ophthalmology, Hadassah-Hebrew<br />
University Medical Center, Jerusalem, Israel;<br />
2<br />
Biochemistry and Molecular Biology, IMRIC,<br />
The Hebrew University-Hadassah Medical School,<br />
Jerusalem, Israel<br />
4530 — 12:30 Identification of regulators<br />
of uveal melanoma metastasis through whole<br />
exome sequencing. Sarah Lake 1 , B. E. Damato 2 ,<br />
H. Kalirai 1 , L. Olohan 3 , X. Liu 3 , S. E. Coupland 1 .<br />
1<br />
Molecular And Clinical Cancer Medicine,<br />
University of Liverpool, Liverpool, United<br />
Kingdom; 2 Royal Liverpool University Hospital,<br />
Liverpool, United Kingdom; 3 Centre for Genomic<br />
Research, University of Liverpool, Liverpool,<br />
United Kingdom<br />
609<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Lens<br />
429 A Global View of Posterior Capsule<br />
Opacification - Minisymposium<br />
Posterior Capsule Opacification (PCO) is the most<br />
common complication of cataract surgery, which<br />
essentially forms by a lens wound-healing response<br />
induced by surgical trauma. Despite advances in<br />
artificial lens implants to delay PCO formation,<br />
significant numbers of patients still experience<br />
visual deterioration that requires laser surgery to<br />
resolve the problem. PCO is therefore far from<br />
eradicated and requires communication between<br />
industry, clinicians and scientists to best understand<br />
the problem and determine novel strategies to<br />
delay or eliminate PCO formation. The proposed<br />
minisymposium will bring together these different<br />
communities to discuss this important problem.<br />
Moderators: Michael Wormstone, Melinda K.<br />
Duncan and Steven Bassnett<br />
— 11:00 Introduction<br />
4531 — 11:05 Polymers, Barriers and Haptics:<br />
The Development of IOLSs in the Prevention<br />
of PCO. David Spalton. Consulting Rooms, King<br />
Edward VII Hospital, London, United Kingdom<br />
*CR<br />
4532 — 11:30 Differentiation in the Lens:<br />
Implications for PCO. Linda Musil. Biochemistry<br />
& Molecular Biology, Oregon Health & Science<br />
Univ, Portland, OR<br />
4533 — 11:55 Lens Cell/ECM Interactions in<br />
PCO. Melinda K. Duncan. Biological Sciences,<br />
University of Delaware, Newark, DE<br />
4534 — 12:20 TGFbeta and PCO: Why Old<br />
Bags Wrinkle. Michael Wormstone. School of<br />
Biological Sciences, University of East Anglia,<br />
Norwich, United Kingdom *CR<br />
611-614<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Retinal Cell Biology<br />
430 Physiologic Vascularization<br />
in Retinopathies<br />
Moderators: Azza B. El-Remessy and Alan W. Stitt<br />
4535 — 11:00 Inhibiting the Ras Pathway<br />
Prevents Ocular Neovascularization by<br />
Repressing Tip Cell Sprouting. Peter D.<br />
Westenskow, T. Kurihara, E. Aguilar, M. Webb,<br />
C. M. Wittgrove, S. K. Moreno, M. Friedlander.<br />
Department of Cell Biology, The Scripps Research<br />
Institute, La Jolla, CA<br />
4536 — 11:15 Endothelial Progenitor Cells<br />
in Bone Marrow, Blood, and Retina Respond<br />
Dynamically to Murine Oxygen-Induced<br />
Retinopathy. Bliss E. O’Bryhim 1, 2 , R. White 1 , R. C.<br />
Symons 1, 3 . 1 Ophthalmology, University of Kansas<br />
Medical Center, Kansas City, KS; 2 Molecular &<br />
Integrative Physiology, Univ of Kansas Medical<br />
Center, Kansas City, KS; 3 Department of Surgery,<br />
University of Melbourne, Melbourne, VIC,<br />
Australia<br />
4537 — 11:30 Neuronal Sirtuin1 mediates<br />
retinal vascular regeneration in retinopathy. Jing<br />
Chen, A. Juan, C. G. Hurst, D. T. Pei, J. Joyal, L.<br />
Evans, Z. Cui, A. Stahl, P. Sapieha, L. E. Smith.<br />
Ophthalmology, Harvard Med Sch Children’s Hosp,<br />
Boston, MA<br />
4538 — 11:45 Vascular Protective Effects of<br />
Candesartan In Ischemic Retinopathy. Azza B.<br />
El-Remessy 1, 2 , A. Y. Shanab 1, 2 , S. Matragoon 1, 2 , S.<br />
C. Fagan 1, 2 . 1 Clin & Experimental Therapeutics,<br />
University of Georgia, Augusta, GA; 2 VA Medical<br />
Center, Augusta, GA *CR<br />
4539 — 12:00 Senescent endothelial progenitor<br />
cells show impaired vasoregenerative capacity<br />
in the ischemic retina. Emma Reid 1 , R. J. Medina 1 ,<br />
M. O’Doherty 1 , C. L. O’Neill 1 , S. Wilson 1 , J.<br />
Guduric-Fuchs 1 , J. Neisen 2 , D. J. Waugh 2 , D. A.<br />
Simpson 1 , A. W. Stitt 1 . 1 Centre for Vision & Vascular<br />
Science, Queen’s University Belfast, Belfast,<br />
United Kingdom; 2 Centre for Cancer Research and<br />
Cell Biology, Queen’s University Belfast, Belfast,<br />
United Kingdom *CR<br />
4540 — 12:15 Lack of Cyp1B1 Promotes<br />
the Proliferative and Migratory Phenotype of<br />
Perivascular Supporting Cells. Nader Sheibani 1 ,<br />
T. L. Palenski 1 , C. M. Sorenson 2 . 1 Ophthalmology<br />
and Visual Sciences, Univ of Wisconsin-Madison,<br />
Madison, WI; 2 Pediatrics, Uinversity of Wisconsin,<br />
Madison, WI<br />
4541 — 12:30 Laminin Regulation of Retinal<br />
Vascularization: Role in Astrocyte Migration<br />
and Differentiation. William J. Brunken 1, 2 ,<br />
G. Bachay 1, 2 , S. Biswas 1, 2 , G. Gnanaguru 1, 2 .<br />
1<br />
Ophthalmology and Cell Biology, SUNY<br />
Downstate Medical Center, Brooklyn, NY; 2 SUNY<br />
Eye Institute, Brooklyn, NY<br />
<strong>Wednesday</strong> Papers/<br />
Minisymposium<br />
11:00 am – 12:45 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
295
4542 – 4559 – <strong>Wednesday</strong> – Papers/Minisymposium<br />
<strong>Wednesday</strong> Papers/<br />
Minisymposium<br />
11:00 am – 12:45 pm<br />
615-617<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Clinical/Epidemiologic Research<br />
431 Eye Care: Who’s Not Getting It and<br />
Why It Matters<br />
Moderators: Pradeep Y. Ramulu and<br />
Nakul Shekhawat<br />
4542 — 11:00 Does government assistance<br />
improve access for low-income individuals to<br />
eye care providers? Chris J. Hong 1 , G. E. Trope 2 ,<br />
Y. M. Buys 2 , B. E. Robinson 4 , Y. Jin 2, 3 . 1 Department<br />
of Medicine, University of Ottawa, Ottawa, ON,<br />
Canada; 2 Department of Ophthalmology and<br />
Vision Sciences, University of Toronto, Toronto,<br />
ON, Canada; 3 Dalla Lana School of Public Health,<br />
University of Toronto, Toronto, ON, Canada;<br />
4<br />
School of Optometry, University of Waterloo,<br />
Waterloo, ON, Canada *CR<br />
4543 — 11:15 The Association of Vision Loss<br />
with Work Status in the United States. Cheryl<br />
Sherrod 2, 1 , K. D. Frick 3, 5 , P. Y. Ramulu 4, 1 . 1 Dana<br />
Center for Preventive Ophthalmology, Wilmer<br />
Eye Institute at Johns Hopkins, Baltimore, MD;<br />
2<br />
Preventive Medicine, Johns Hopkins Bloomberg<br />
School of Public Health, Baltimore, MD; 3 Health<br />
Policy & Management, Johns Hopkins Bloomberg<br />
School of Public Health, Baltimore, MD;<br />
4<br />
Glaucoma Division, Wilmer Eye Institute at Johns<br />
Hopkins, Baltimore, MD; 5 International Health,<br />
Johns Hopkins Bloomberg School of Public Health,<br />
Baltimore, MD *CR<br />
4544 — 11:30 Despite Possessing Health<br />
Insurance, Large Disparities Exist in Likelihood<br />
of Visits to Eye Care Providers Across U.S.<br />
Sociodemographic Groups. Patricia A. Pleplakon<br />
1 , C. A. Andrews 1 , D. C. Musch 1, 2 , P. P.<br />
Lee 1 , J. D. Stein 1 . 1 Ophthalmology and Visual<br />
Sciences, University of Michigan, Ann Arbor, MI;<br />
2<br />
Epidemiology, University of Michigan, Ann Arbor,<br />
MI *CR<br />
4545 — 11:45 The global burden of potential<br />
productivity loss from presbyopia. Susan M.<br />
Joy 1 , K. D. Frick 1 , K. S. Naidoo 2 , D. A. Wilson 2 ,<br />
B. A. Holden 2, 3 . 1 Department of Health Policy<br />
and Management, Johns Hopkins Bloomberg<br />
School of Public Health, Baltimore, MD; 2 Brien<br />
Holden Vision Institute, Sydney, NSW, Australia;<br />
3<br />
University of New South Wales, Sydney, NSW,<br />
Australia *CR<br />
4546 — 12:00 An Evaluation of Non-Physician<br />
Educators’ Role In Enhancing Cataract Patient’s<br />
Surgical Knowledge and Satisfaction. Paula<br />
Anne Newman-Casey 1 , S. Ravilla 2 , H. Aravind 2 ,<br />
V. Palanichamy 2 , M. Pillai 2 , V. Balakrishnan 2 , A.<br />
L. Robin 3 . 1 Ophthalmology & Visual Sciences,<br />
Kellogg Eye Ctr, Univ of Michigan, Ann Arbor,<br />
MI; 2 Ophthalmology and Visual Sciences, Aravind<br />
Eye Care System, Madurai, India; 3 Ophthalmology<br />
and Visual Sciences, Johns Hopkins University,<br />
Baltimore, MD *CR<br />
4547 — 12:15 Cohort- and age-specific<br />
effects of annual mass drug administration on<br />
prevalence of trachoma: a longitudinal study in<br />
rural Tanzania. Nakul Shekhawat 1, 2 , B. E. Munoz 1 ,<br />
H. A. Mkocha 3 , S. K. West 1, 2 . 1 Dana Center for<br />
Preventative Ophthalmology, Wilmer Eye Institute,<br />
Johns Hopkins, Baltimore, MD; 2 Johns Hopkins<br />
Bloomberg School of Public Health, Baltimore,<br />
MD; 3 Kongwa Trachoma Project, Kongwa, United<br />
Republic of Tanzania<br />
4548 — 12:30 Time-Motion Analysis of Clinical<br />
Nursing Documentation during Implementation<br />
of an Electronic Operating Room Management<br />
System for Ophthalmic Surgery. Sarah Read-<br />
Brown 1 , A. S. Brown 1 , T. R. Yackel 2 , D. Choi 3 ,<br />
D. C. Tu 1, 4 , D. S. Sanders 1 , M. F. Chiang 1, 2 .<br />
1<br />
Ophthalmology, Oregon Health & Science<br />
University, Portland, OR; 2 Medical Informatics &<br />
Clinical Epidemiology, Oregon Health & Science<br />
University, Portland, OR; 3 Public Health &<br />
Preventative Medicine, Oregon Health & Science<br />
University, Portland, OR; 4 Portland Veterans<br />
Administration Medical Center, Portland, OR *CR<br />
TCC LL 4/5<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Visual Psychophysics / Physiological Optics<br />
432 Refractive Errors, Myopia II<br />
Moderators: Arthur Bradley and Frank Schaeffel<br />
4549 — 11:00 The impact of Spherical<br />
Aberration, Stiles Crawford Apodization and<br />
Spatial Frequency on wavefront-based and<br />
subjective refractions. Renfeng Xu 1 , A. Bradley 1 ,<br />
L. N. Thibos 1 , G. Marin 2 , M. Hernandez 2 . 1 School<br />
of Optometry, Indiana University, Bloomington, IN;<br />
2<br />
Essilor International, Paris, France *CR<br />
4550 — 11:15 Impact of Primary and<br />
Secondary Spherical Aberration on Predicted<br />
Peripheral Image Quality. Amanda C. Kingston 1, 2 ,<br />
G. Yoon 2 . 1 BME, University of Rochester,<br />
Rochester, NY; 2 Flaum Eye Institute, University of<br />
Rochester, Rochester, NY *CR<br />
4551 — 11:30 Peripheral Wavefront<br />
Aberrations of Accommodating Human Eye. Tao<br />
Liu, L. N. Thibos. School of Optometry, Indiana<br />
University, Bloomington, Bloomington, IN *CR<br />
4552 — 11:45 1 Changes in Ocular Biometrics<br />
and Refraction during Near Work in Downward<br />
Gaze over Time. Atanu Ghosh, M. J. Collins, B.<br />
A. Davis, S. A. Read, F. Yi, P. Chatterjee. School<br />
of Optometry and Vision Science, Queensland<br />
University of Technology, Brisbane, QLD, Australia<br />
4553 — 12:00 Effect of Accommodation on<br />
Peripheral Refraction. Jason Shen, F. Spors.<br />
College of Optometry, Western Univ of Hlth<br />
Sciences, Pomona, CA<br />
4554 — 12:15 School-Age Myopic Shift in<br />
Hyperopic Children with Infantile Esotropia and<br />
Peripheral Myopia. Eileen E. Birch 1, 2 , S. Li 1 , S. E.<br />
Morale 1 , R. M. Jost 1 , V. Subramanian 1 , D. O. Mutti 3 .<br />
1<br />
Retina Foundation of the Southwest, Dallas, TX;<br />
2<br />
Ophthalmology, UT Southwestern Medical Center,<br />
Dallas, TX; 3 College of Optometry, The Ohio State<br />
University, Columbus, OH<br />
TCC 303<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Cornea / Cornea<br />
433 Stroma Keratocytes, Development<br />
and Dystrophies<br />
Moderators: Albert S. Jun and Sophie X. Deng<br />
4555 — 11:00 Wnt/b-catenin canonical<br />
signaling in corneal keratocytes regulates<br />
epithelium stratification through repressing<br />
Bmp4/Mapk pathway. Yujin Zhang 1 , L. Yeh 2 ,<br />
W. W. Kao 1 , C. Liu 1 . 1 Ophthalmology, University<br />
of Cincinnati School of Med, Cincinnati, OH;<br />
2<br />
Ophthalmology, Chang-Gung Memorial Hospital,<br />
Linko, Taiwan<br />
4556 — 11:15 Peptide Amphiphiles as<br />
Versatile Substrates for Oriented Cell Adhesion<br />
and Proliferation of Human Cornea Stromal<br />
Keratocytes. Ricardo M. Gouveia, V. Castelletto, I.<br />
Hamley, C. J. Connon. School of Chemistry, Food<br />
and Pharmacy, University of Reading, Reading,<br />
United Kingdom<br />
4557 — 11:30 Limbal Biopsy As a Source of<br />
Stem Cells for Autologous Stromal Cell-based<br />
Therapy. Sayan Basu 1, 2 , M. L. Funderburgh 1 , J.<br />
L. Funderburgh 1 . 1 Ophthalmology, University of<br />
Pittsburgh School of Medicine, Pittsburgh, PA;<br />
2<br />
Cornea, L V Prasad Eye Institute, Hyderabad, India<br />
4558 — 11:45 Mass Spectrometric - Based<br />
Proteomic Analysis of TGFBI Corneal<br />
Dystrophies. Aarika Menees 1 , S. Dasari 2 , A.<br />
Dogan 2 , S. V. Patel 1 , K. H. Baratz 1 , J. D. Theis 2 , J.<br />
A. Vrana 2 , D. R. Salomao 2, 1 . 1 Ophthalmology, Mayo<br />
Clinic, Rochester, MN; 2 Laboratory Medicine and<br />
Pathology, Mayo Clinic, Rochester, MN *CR<br />
4559 — 12:00 Investigation of Gene Therapy<br />
Using Immortalized Cells Derived from a<br />
Gelatinous Drop-Like Corneal Dystrophy<br />
Patient. Koji Kitazawa 1 , S. Kawasaki 1 , K.<br />
Aoi 3, 1 , K. Shinomiya 1 , A. Matsuda 2 , T. Funaki 2 ,<br />
M. Nakatsukasa 1 , J. Hamuro 1 , A. Murakami 2 ,<br />
S. Kinoshita 1 . 1 Kyoto Prefectural Univ of Med,<br />
Kyoto, Japan; 2 Juntendo University, Tokyo, Japan;<br />
3<br />
Doshisya University, Kyoto, Japan *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
296
<strong>Wednesday</strong> – Papers/Minisymposium – 4560 – 4574<br />
4560 — 12:15 A Family-based Investigation<br />
of the Role of TCF4 Trinucleotide Repeat<br />
Expansion in Fuchs Endothelial Corneal<br />
Dystrophy (FECD). Keith H. Baratz 1 , R. A.<br />
Aleff 2 , Y. Li 3 , M. L. Butz 4 , S. G. Gregory 5 , G. K.<br />
Klintworth 6 , W. Highsmith 4 , N. A. Afshari 7 , E. D.<br />
Wieben 2 . 1 Ophthalmology, Mayo Clinic, Rochester,<br />
MN; 2 BIochemistry and Molecular Biology,<br />
Mayo Clinic, Rochester, MN; 3 Biostatistics and<br />
BioInformatics, Center for Human Genetics,<br />
Duke University Medical Center, Durham, NC;<br />
4<br />
Laboratory Medicine and Pathology, Mayo Clinic,<br />
Rochester, MN; 5 Medicine, Molecular Genetics and<br />
Microbiology, Duke University Medical Center,<br />
Durham, NC; 6 Ophthalmology, Duke University<br />
Medical Center, Durham, NC; 7 Ophthalmology,<br />
University of California, San Diego, San Diego,<br />
CA *CR<br />
4561 — 12:30 AGBL1 implicated in the<br />
pathogenesis of late-onset FCD and interacts<br />
with TCF4. John D. Gottsch 1 , S. Vasanth 2 , N.<br />
Katsanis 2 , S. Riazuddin 1 . 1 Wilmer Eye Institute,<br />
Johns Hopkins University School of Medicine,<br />
Baltimore, MD; 2 Center for Human Disease<br />
Modeling, Duke University Medical Center,<br />
Durham, NC<br />
TCC 304<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Visual Neuroscience<br />
434 Genetics, Development and Aging<br />
Moderators: Rachel O. Wong and Anand Swaroop<br />
4562 — 11:00 Distinct Roles Of Activity-<br />
Dependent And Independent Mechanisms<br />
In Regulating The Bipolar Cell Inputs Onto<br />
Retinal Ganglion Cells. Haruhisa Okawa 1 , L.<br />
Della Santina 1 , G. Schwartz 2 , D. Kerschensteiner 3 ,<br />
F. Rieke 2 , R. O. Wong 1 . 1 Biological Structure,<br />
University of Washington, Seattle, WA; 2 Physiology<br />
and Biophysics, University of Washington,<br />
Seattle, WA; 3 Ophthalmology and Visual Sciences,<br />
Washington University, St. Louis, MO<br />
4563 — 11:15 Following the Ontogeny of<br />
Retinal Waves: Pan-Retinal Recordings of<br />
Population Dynamics in the Neonatal Mouse.<br />
Evelyne Sernagor 1 , M. H. Hennig 2 , A. Maccione 3 ,<br />
M. Gandolfo 3 , J. Muthmann 2 , S. J. Eglen 4 , L.<br />
Berdondini 3 . 1 Institute of Neuroscience, Newcastle<br />
Univ Medical School, Newcastle Upon Tyne,<br />
United Kingdom; 2 Institute for Adaptive and Neural<br />
Computation, School of Informatics, University of<br />
Edinburgh, Edinburgh, United Kingdom; 3 Dept.<br />
of Neuroscience and Brain Technologies, Italian<br />
Institute of Technology, Genova, Italy; 4 Cambridge<br />
Computational Biology Institute, Cambridge<br />
University, Cambridge, United Kingdom *CR<br />
4565 — 11:45 Epigenetic maintenance of<br />
adult cone photoreceptors. Volker Busskamp 1, 2 ,<br />
J. Krol 2 , K. Farrow 2 , J. Juettner 2 , D. Nelidova 2 , V.<br />
Sothilingam 3 , M. Garcia Garrido 3 , M. W. Seeliger 3 ,<br />
W. Filipowicz 2 , B. Roska 2 . 1 Genetics, Harvard<br />
Medical School, Boston, MA; 2 Friedrich Miescher<br />
Institute, Basel, Switzerland; 3 Division of Ocular<br />
Neurodegeneration, Institute for Ophthalmic<br />
Research, Tuebingen, Germany *CR<br />
4566 — 12:00 Down-regulation of oxidative<br />
phosphorylation genes and up-regulation<br />
of protein degradation pathway genes are a<br />
hallmark of aging rod photoreceptors in mouse<br />
retina. Tiziana Cogliati 1 , J. Barb 2 , N. Gotoh 3 , M.<br />
Brooks 1 , L. Gieser 1 , N. Gupta 1 , R. Villasmil 4 , I.<br />
Lee 5 , P. J. Munson 2 , A. Swaroop 1 . 1 NNRL, National<br />
Eye Institute - NIH, Bethesda, MD; 2 CIT, NIH,<br />
Bethesda, MD; 3 Department of Ophthalmology and<br />
Visual Sciences, Kyoto University, Kyoto, Japan;<br />
4<br />
Flow Cytometry Core, National Eye Institute -<br />
NIH, Bethesda, MD; 5 MirCore, Ann Arbor, MI *CR<br />
4567 — 12:15 Synaptic localization but not<br />
specificity is mediated by Down Syndrome Cell<br />
Adhesion Molecule. Peter G. Fuerst 1, 2 , S. Li 1 ,<br />
D. Schramm 1 . 1 Biological Sciences, University of<br />
Idaho, Moscow, ID; 2 UWSOM WWAMI Medical<br />
Education Program, University of Idaho, Moscow,<br />
ID<br />
4568 — 12:30 Developmental changes in<br />
subunit- and pathway-specific expression of<br />
NMDA receptors in direction-selective ganglion<br />
cells. Ben Stafford 1 , K. Y. Wong 1, 2 , J. B. Demb 3 .<br />
1<br />
Ophthalmology and Visual Sciences, University<br />
of Michigan, Ann Arbor, MI; 2 Molecular, Cell, and<br />
Developmental Biology, University of Michigan,<br />
Ann Arbor, MI; 3 Ophthalmology and Visual<br />
Sciences, Yale University, New Haven, CT<br />
TCC 305<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Eye Movements / Strabismus / Amblyopia /<br />
Neuro-Ophthalmology<br />
435 Neuro-Ophthalmology: Novel<br />
Treatments and Mechanisms of Disease<br />
Moderators: Yaping J. Liao and<br />
Prem S. Subramanian<br />
4569 — 11:00 MTS-AAV Delivery of Human<br />
ND4 in the Mouse Eye. John Guy 1 , H. Yu 1 , A.<br />
Mehta 2 , G. Wang 2 . 1 Bascom Palmer Eye Institute,<br />
University of Miami, Miami, FL; 2 Genomics,<br />
Hussman Institute of Human Genomics, Miami, FL<br />
4570 — 11:15 Retinal ganglion cells exhibit<br />
spontaneous hyperactivity and abnormally<br />
sustained light-evoked responses in in a mouse<br />
model of traumatic brain injury. Matthew<br />
Harper 1 , F. R. Blodi 2, 4 , M. Shankar 2, 4 , E.<br />
Hernandez-Merino 1, 3 , H. Kecova 1, 3 , L. Dutca 1, 3 ,<br />
R. H. Kardon 1, 3 , S. F. Stasheff 2, 3 . 1 Center for<br />
the Prevention and Treatment of Visual Loss,<br />
Department of Veterans Affairs, Iowa City, IA;<br />
2<br />
Pediatrics, University of Iowa, Iowa CIty, IA;<br />
3<br />
Ophthalmology and Visual Science, University<br />
of Iowa, Iowa CIty, IA; 4 Children’s Hospital,<br />
University of Iowa, Iowa CIty, IA *CR<br />
4571 — 11:30 TrkB Neurotrophin Receptor<br />
Activation with Pharmacophore as Possible<br />
Treatment for Anterior Ischemic Optic<br />
Neuropathy. Yaping J. Liao 1 , G. Lee 1 , J. Ma 1 , T.<br />
Yang 2 , C. Chakraborty 2 , B. Barres 3 , F. Longo 2 , M.<br />
Shariati 1 . 1 Ophthalmology, Byers Eye Institute<br />
at Stanford, Stanford, CA; 2 Neurology, Stanford,<br />
Stanford, CA; 3 Neurobiology, Stanford, Stanford,<br />
CA<br />
4572 — 11:45 Genotype-retinal phenotype<br />
correlations in infantile nystagmus. Mervyn G.<br />
Thomas 1 , V. Sheth 1 , R. J. McLean 1 , F. A. Proudlock 1 ,<br />
G. Maconachie 1 , S. Kohl 4 , W. Chan 2 , C. Andrews 2 ,<br />
E. C. Engle 2, 3 , I. Gottlob 1 . 1 Ophthalmology Group,<br />
University of Leicester, Leicester, United Kingdom;<br />
2<br />
Department of Neurology, Boston Children’s<br />
Hospital, Boston, MA; 3 Departments of Neurology,<br />
Ophthalmology, Medicine (Genetics), Harvard<br />
Medical School and Boston Children’s Hospital,<br />
Boston, MA; 4 Centre for Ophthalmology, Institute<br />
for Ophthalmic Research, Tuebingen, Germany<br />
4573 — 12:00 Visual outcomes of the<br />
surgical treatment of idiopathic intracranial<br />
hypertension. Prem S. Subramanian 1, 2 , P.<br />
Fonseca 1 , N. R. Miller 1, 2 , D. Rigamonti 2 . 1 Wilmer<br />
Eye Institute, Baltimore, MD; 2 Neurosurgery, Johns<br />
Hopkins Unversity Sch of Med, Baltimore, MD<br />
*CR<br />
4574 — 12:15 Treatment of Leber’s hereditary<br />
optic neuropathy (LHON): Results using a<br />
novel quinone, EPI-743. Carlos F. Chicani 1, 2 ,<br />
E. R. Chu 2 , F. N. Ross-Cisneros 2 , S. Rockwell 2 , K.<br />
Murase 3 , M. Thoolen 3 , G. Miller 3, 4 , A. A. Sadun 2 .<br />
1<br />
Ophthalmology, Federal University of Sao Paulo<br />
- UNIFESP, Sao Paulo, Brazil; 2 Ophthalmology,<br />
Doheny Eye Institute - University of Southern<br />
California - Keck School of Medicine, Los Angeles,<br />
CA; 3 Edison Pharmaceuticals, Mountain View, CA;<br />
4<br />
Anesthesiology, Stanford University, Stanford, CA<br />
*CR<br />
<strong>Wednesday</strong> Papers/<br />
Minisymposium<br />
11:00 am – 12:45 pm<br />
4564 — 11:30 Dendrites of melanopsin<br />
ganglion cells transiently extend into the outer<br />
retina in early postnatal development. Jordan<br />
M. Renna, D. K. Chellappa, M. E. Estevez, D.<br />
M. Berson. Neuroscience, Brown University,<br />
Providence, RI<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
297
4575 – <strong>Wednesday</strong> – Papers/Minisymposium<br />
4575 — 12:30 A Phase I Open Label, Dose<br />
Escalation Trial Of QPI-1007 Delivered By A<br />
Single Intravitreal (IVT) Injection To Subjects<br />
With Low Visual Acuity And Acute Non-<br />
Arteritic Anterior Ischemic Optic Neuropathy<br />
(NAION). Andrew N. Antoszyk 1, 2 , B. Katz 3 ,<br />
R. Singh 4 , R. Gurses-Ozden 5 , S. S. Erlich 5 , D.<br />
Rothenstein 5 , N. Sharon 5 , J. Hodge 5 , L. A. Levin 6, 7 ,<br />
N. R. Miller 8 . 1 Retina, Charlotte EEN&T Associates,<br />
Charlotte, NC; 2 Surgery, Uniformed Services<br />
University of the Health Sciences, Bethesda, MD;<br />
3<br />
Ophthalmology and Visual Sciences, University<br />
of Utah Health Sciences Center, Salt Lake City,<br />
UT; 4 Ophthalmology, Cleveland Clinic Foundation,<br />
Cleveland, OH; 5 Quark Pharmaceuticals, Inc.,<br />
Fremont, CA; 6 Ophthalmology, McGill University,<br />
Montreal, QC, Canada; 7 Ophthalmology and Visual<br />
Sciences, University of Wisconsin, Madison, WI;<br />
8<br />
Wilmer Eye Institute, Johns Hopkins University,<br />
Baltimore, MD *CR, f<br />
<strong>Wednesday</strong> Papers/<br />
Minisymposium<br />
11:00 am – 12:45 pm<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
298
<strong>Wednesday</strong> – Posters – 4576 – 4596<br />
Exhibit Hall A0095-A0113<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Biochemistry/Molecular Biology<br />
436 AMD I, BI<br />
Moderator: Aparna Lakkaraju<br />
4576 — A0095 Autophagy disregulation in<br />
the retina during aging and neurodegeneration.<br />
Enrique J. de la Rosa 1 , N. Rodriguez-Muela 2 ,<br />
H. Koga 3 , L. Garcia-Ledo 2 , P. de la Villa 4 , A. M.<br />
Cuervo 3 , P. Boya 2 . 1 Cell & Molecular Medicine,<br />
Centro de Investigaciones Biologicas, Madrid,<br />
Spain; 2 Cell & Molecular Biology, Centro de<br />
Investigaciones Biologicas CSIC, Madrid, Spain;<br />
3<br />
Institute for Aging Studies, Albert Einstein College<br />
of Medicine, Bronx, NY; 4 Physiology, School of<br />
Medicine, University of Alcala, Alcala de Henares,<br />
Spain *CR<br />
4577 — A0096 High glucose activates<br />
ChREBP-mediated HIF-1α and VEGF<br />
expression in human RPE cells under normoxia.<br />
Min-Lee Chang, C. Chiu, F. Shang, A. Taylor.<br />
HNRCA Tufts University, Boston, MA<br />
4578 — A0097 AMD-associated silent<br />
polymorphisms in HtrA1 ameliorate IGF-1<br />
antagonism. Sarah Melissa P. Jacobo 1, 2 , M. M.<br />
DeAngelis 3, 4 , A. Kazlauskas 1, 2 . 1 Ophthalmology,<br />
Harvard Medical School, Boston, MA; 2 The<br />
Schepens Eye Research Institute, Boston, MA;<br />
3<br />
Ophthalmology and Visual Sciences, University<br />
of Utah, Salt Lake City, UT; 4 John A. Moran Eye<br />
Center, Salt Lake City, UT<br />
4579 — A0098 Differences in Reactive Oxygen<br />
Species (ROS) Production and Expression of<br />
Genes from the Complement and Inflammatory<br />
Pathways Between H and K Haplogroup<br />
Cybrids. Javier Cáceres del Carpio 1 , M. Tarek 1 ,<br />
C. A. Ramirez 1 , P. Falatoonzadeh 1 , M. Chwa 1 ,<br />
D. Malik 1 , S. Jazwinski 2 , M. V. Michael 2 , B. D.<br />
Kuppermann 1 , C. M. Kenney 1 . 1 Gavin Herbert Eye<br />
Institute, University of California Irvine, Irvine,<br />
CA; 2 Tulane Center for Aging, Tulane University,<br />
New Orleans, LA *CR<br />
4580 — A0099 Stimulation of Semaphorin3E/<br />
PlexinD1 pathway has anti-angiogenic<br />
effect in experimental model of choroidal<br />
neovascularization. Kenji Suda, C. Guo, A. Oishi,<br />
S. Ikeda, N. Yoshimura. Ophthalmology, Kyoto<br />
University, Kyoto, Japan *CR<br />
4581 — A0100 Adiponectin Peptide II<br />
(APNpII) effect on human ARPE-19 cells.<br />
Puran S. Bora, N. S. Bora, V. V. Lyzogubov.<br />
Ophthalmology, Jones Eye Institute-UAMS, Little<br />
Rock, AR<br />
4582 — A0101 Isoform-specific interactions<br />
between human apolipoprotein E and amyloidbeta<br />
in the retinal pigment epithelium. Kimberly<br />
A. Toops, J. Xu, A. Lakkaraju. Ophthalmology<br />
and Visual Sciences, University of Wisconsin -<br />
Madison, Madison, WI<br />
4583 — A0102 Effects of the absence of both<br />
complement factor H and apolipoprotein E<br />
on VEGF expression, MMP2/9 activity and<br />
caspase-1. Laura Garcia-Garcia, P. Fernandez, S.<br />
Recalde, M. Moreno-Orduña, V. Fernandez-Garcia,<br />
A. Garcia-Layana. Ophthalmology Experimental<br />
Laboratory, Clinica Universidad de Navarra,<br />
Pamplona, Spain<br />
4584 — A0103 Surface plasmon resonance<br />
indicates that complement factor H, C3b and<br />
native properdin bind to carboxyethylpyrroleadducted<br />
BSA. Lisa Kuttner-Kondo 1 , V. P.<br />
Ferreira 2 , C. Cortes 2 , S. P. Yadav 3 , J. G. Hollyfield 1 .<br />
1<br />
Ophthalmic Research, Cole Eye Institute,<br />
Cleveland Clinic Foundation, Cleveland, OH;<br />
2<br />
Dept. of Medical Microbiology and Immunology,<br />
University of Toledo College of Medicine, Toledo,<br />
OH; 3 Molecular Biotechnology Core, Lerner<br />
Research Institute, Cleveland Clinic Foundation,<br />
Cleveland, OH<br />
4585 — A0104 The aging retina: Macula-less<br />
rat and macula-bearing monkey retinae exhibit<br />
common age-related changes in their retinal<br />
proteins. Michael R. Boehm 1, 2 , S. Mertsch 1 , H.<br />
Melkonyan 1 , S. Thanos 1 . 1 Institute for Experimental<br />
Ophthalmology, School of Medicine, WWU<br />
Muenster, Muenster, Germany; 2 Current Affiliation:<br />
Department of Ophthalmology, University of<br />
Muenster Medical Center, Muenster, Germany<br />
4586 — A0105 Gene expression profile of<br />
Retinal Pigment Epithelium derived ARPE-<br />
19 cells under serum starvation. Sanghamitra<br />
Mishra 1 , K. M. Peterson 1 , A. E. Berger 2 , G. J.<br />
Wistow 1 . 1 Section for Molecular Structure and<br />
Functional Genomics, National Eye Institute,<br />
Bethesda, MD; 2 JHBMC Lowe Family Genomics<br />
Core, Johns Hopkins University - School of<br />
Medicine, Baltimore, MD<br />
4587 — A0106 HSPA5 - a possible new<br />
contributing gene in atrophic age-related<br />
macular degeneration. Sumana Chintalapudi,<br />
Y. H. Chan Lau, S. Sahu, M. M. Jablonski.<br />
Ophthalmology, The University of Tennessee<br />
Health Science Center, Memphis, TN *CR<br />
4588 — A0107 Quercetin Inhibits H2O2<br />
Stimulated PEDF and FGF2 Synthesis in hRPE<br />
Cells. Nandita Anand, P. C. Kothary, M. A. Del<br />
Monte. University of Michigan, Ann Arbor, MI<br />
4589 — A0108 AMD-like phenotypes in<br />
transgenic mice over-expressing BMP4 in RPE.<br />
Danhong Zhu 1 , J. Xu 1 , X. Deng 1 , J. Hsiung 1 , S.<br />
J. Ryan 2 , D. R. Hinton 1, 2 . 1 Pathology, University<br />
of Southern California, Los Angeles, CA;<br />
2<br />
ophthalmology, University of Southern California,<br />
Los Angeles, CA *CR<br />
4590 — A0109 Vitamin D Status and<br />
Subretinal Fibrosis in Neovascular Age-Related<br />
Macular Degeneration. Amardeep Singh 1, 2 ,<br />
M. K. Falk 1, 2 , Y. Subhi 1, 2 , T. L. Sørensen 1, 2 .<br />
1<br />
Ophthalmology, Copenhagen University Hospital<br />
Roskilde, Roskilde, Denmark; 2 University of<br />
Copenhagen, Copenhagen, Denmark<br />
4591 — A0110 Cd46 -/- Mouse as a Model of<br />
Dry-type Age-related Macular Degeneration.<br />
Valeriy V. Lyzogubov 1 , X. Wu 2 , G. Kolar 2 , P. S.<br />
Bora 1 , J. P. Atkinson 2 , N. S. Bora 1 . 1 Ophthalmology,<br />
Jones Eye Institute - UAMS, Little Rock, AR;<br />
2<br />
Department of Medicine, Washington University<br />
School of Medicine, St. Louis, MO<br />
4592 — A0111 Tissue Inhibitor of<br />
Metalloproteinase-3 (TIMP3) Induces<br />
Endothelial Apoptosis via MMP- and Caspase-<br />
Independent Mechanisms. Jian H. Qi, B. Anand-<br />
Apte. Ophthalmic Research-ColeEye Inst, Cole Eye<br />
Institute, Cleveland, OH *CR<br />
4593 — A0112 Localization of<br />
mechanotransduction channels in the trabecular<br />
meshwork of glaucomatous DBA/2J mice. Phi<br />
Ho, V. T. Tran, L. Cabrera, S. K. Bhattacharya.<br />
Bascom Palmer Eye Institute, University of Miami<br />
Miller School of Medicine, Miami, FL<br />
4594 — A0113 CTRP5 over-expression in<br />
RPE cells leads to loss of RPE cell adhesion and<br />
retinal degeneration in wild-type mice. Astra<br />
Dinculescu 1 , S. Min 1 , W. Deng 1 , J. Li 1 , R. C. Ryals 1 ,<br />
R. M. Stupay 1 , P. Zhu 1 , B. Sahu 2 , R. Ayyagari 2 , W. W.<br />
Hauswirth 1 . 1 Ophthalmology, University of Florida,<br />
Gainesville, FL; 2 Shiely Eye Center, University of<br />
California, San Diego, La Jolla, CA *CR<br />
Exhibit Hall A0146-A0178<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Retinal Cell Biology<br />
437 Translational Approaches in AMD<br />
and DR<br />
Moderators: Ruth B. Caldwell and Alfred S. Lewin<br />
4595 — A0146 Not age but the rate of aging<br />
drives the pathogenesis of age related macular<br />
degeneration in primates. Peter Gouras 1 , L. Ivert 2 ,<br />
M. Neuringer 3 , J. Mattison 4 . 1 Ophthalmology/Eye<br />
Institute, Columbia University, New York, NY;<br />
2<br />
Retina S:t Eriks Eyehospital, Karolinska institute,<br />
Stockholm, Sweden; 3 Ophthalmology, Oregon<br />
Health and Science university, Beaverton, OR;<br />
4<br />
Experimental Gerontology, National Institute on<br />
Aging, Baltimore, MD *CR<br />
4596 — A0147 The dual PPAR-α/γ agonist<br />
aleglitazar attenuates retinopathy in<br />
streptozotocin diabetic rats. Raul de la Flor 1 ,<br />
M. B. Wright 2 , A. P. Adamis 3 , J. S. Ehrlich 3 , D. T.<br />
Shima 1 . 1 UCL Institute of Ophthalmology, London,<br />
United Kingdom; 2 Pharma Research & Early<br />
Development,DTA Cardiovascular & Metabolism,<br />
F. Hoffmann-La Roche Ltd, Basel, Switzerland;<br />
3<br />
Genentech, South San Francisco, CA *CR<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
299
4597 – 4618 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
4597 — A0148 Overactive Arginase Causes<br />
Mitochondrial Dysfunction and Premature<br />
Endothelial Cell Senescence during Diabetic<br />
Retinopathy. Ruth B. Caldwell 1, 3 , S. Narayanan 1 ,<br />
M. A. Rojas 1 , T. Lemtalsi 1 , Z. Xu 1 , K. Jittiporn 1 ,<br />
E. Schenhals 1 , R. W. Caldwell 2 , D. J. Fulton 1, 2 .<br />
1<br />
Vascular Biology Center, Georgia Health<br />
Sciences University, Augusta, GA; 2 Department<br />
of Pharmacology & Toxicology, Georgia Health<br />
Sciences University, Augusta, GA; 3 Charlie<br />
Norwood VA Medical Center, Augusta, GA<br />
4598 — A0149 Potential beneficial effects<br />
of carotenoids on diabetic retinopathy. Renu<br />
A. Kowluru 1 , Q. Zhong 1 , J. M. Santos 1 , M.<br />
ThandampallayamAjje 1 , D. Putt 1 , D. L. Gierhart 2 .<br />
1<br />
Ophthalmology, Wayne State Univ/Kresge Eye<br />
Inst, Detroit, MI; 2 Zeavision, L.L.C, Chesterfield,<br />
MO *CR<br />
4599 — A0150 The Impact on Vision and<br />
Regression of Retinal Neovascularization of Anti-<br />
VEGF Induction in Combination with Quarterly<br />
Anti-VEGF Maintenance or Selective PRP versus<br />
Standard PRP. Victor H. Gonzalez. Valley Retina<br />
Institute PA, Harlingen, TX *CR, f<br />
4600 — A0151 Matrix metalloproteinase-9<br />
regulates angiogenic and vasculogenic factors<br />
in diabetic retina. Ghulam Mohammad, A. Abu<br />
El-Asrar. Ophthalmology, king Saud University,<br />
Riyadh, Saudi Arabia<br />
4601 — A0152 Subtoxic Dosage of<br />
Methylglyoxal Stimulated Production of<br />
Urokinase-Type Plasminogen Activator by<br />
Retinal Pigment Epithelial Cells. Anthony<br />
Sclafani 1 , D. Hu 1, 2 , T. Vagaggini 1 , S. A.<br />
McCormick 1, 2 . 1 The NY Eye & Ear Infirmary, New<br />
York, NY; 2 New York Medical College, Valhalla,<br />
NY *CR<br />
4602 — A0153 microRNA-30a Antagonism<br />
Inhibits Ras Signaling and Prevents<br />
Neovascularization. Carli M. Wittgrove, P. D.<br />
Westenskow, T. Kurihara, E. Aguilar, S. K. Moreno,<br />
M. Friedlander. Cell Biology, The Scripps Research<br />
Institute, La Jolla, CA<br />
4603 — A0154 Ranibizumab and Bevacizumab<br />
Decrease Macular Ganglion Cell Complex<br />
(GCC) Thickness Measured with Fourier-<br />
Domain Optical Coherence Tomography in Age-<br />
Related Macular Degeneration (AMD). Nalin<br />
J. Mehta 1 , H. Quiroz-Mercado 2, 3 , M. J. Sinai 6 , K.<br />
A. Soules 4 , A. N. Mehta 5 , S. Schwartz 2, 3 . 1 Colorado<br />
Retina Center, Lakewood, CO; 2 Department of<br />
Ophthalmology, Denver Health Medical Center,<br />
Denver, CO; 3 Department of Ophthalmology,<br />
University of Colorado, Denver, CO; 4 Optovue Inc.,<br />
Fremont, CA; 5 Colorado Academy, Denver, CO;<br />
6<br />
formerly Optovue Inc., Fremont, CA *CR<br />
4604 — A0155 A new mouse model of dry<br />
form AMD. Haoyu Mao, A. S. Lewin, M. Conners.<br />
Molecular Genetics and Microbiology, University<br />
of Florida, Gainesville, FL *CR<br />
4605 — A0156 Serine/Arginine-Rich Protein<br />
Kinase Blockade Attenuates Choroidal<br />
Neovascularization. Zhenyu Dong 1, 2 , K. Noda 1, 2 , A.<br />
Kanda 1, 2 , J. Fukuhara 1, 2 , R. Ando 1, 2 , M. Murata 1, 2 ,<br />
W. Saito 2 , M. Hagiwara 3 , S. Ishida 1, 2 . 1 Laboratory of<br />
Ocular Cell Biology and Visual Science, Hokkaido<br />
University Graduate School of Medicine, Sapporo,<br />
Japan; 2 Department of Ophthalmology, Hokkaido<br />
University Graduate School of Medicine, Sapporo,<br />
Japan; 3 Department of Anatomy and Developmental<br />
Biology, Kyoto University Graduate School of<br />
Medicine, Kyoto, Japan *CR<br />
4606 — A0157 Osteopontin (OPN) is Present<br />
in Drusen and Basal Deposits in Human Eyes<br />
with Age-Related Macular Degeneration (AMD).<br />
Amanda Bednar, M. Choudhary, P. Saloupis, A. D.<br />
Proia, G. Malek. Opthamology, Duke University,<br />
Durham, NC<br />
4607 — A0158 The Role of Abnormal Blood<br />
Flow in Age-Related Macular Degeneration.<br />
Luis Alarcon-Martinez 1, 2 , H. Rieiro 1 , T. Demirci 1 ,<br />
R. Leal-Campanario 1, 3 , S. Martinez-Conde 1 , S. L.<br />
Macknik 1 . 1 Neurobiology, Barrow Neurological<br />
Institute, Phoenix, AZ; 2 Ophthalmology,<br />
University of Murcia, Murcia, Spain; 3 División<br />
de Neurociencias, Universidad Pablo de Olavide,<br />
Sevilla, Spain<br />
4608 — A0159 RPE, Bruch’s membrane<br />
changes in rabbit eyes and a human eye with<br />
retinal photoxicity. Mehmet Koray Sevinc 1 , U.<br />
Erdem 1 , A. Kubar 2 , E. Oztas 3 . 1 Ophthalmology,<br />
Gülhane Military Medical Faculty, Ankara, Turkey;<br />
2<br />
Microbiology, Gülhane Military Medical Faculty,<br />
Ankara, Turkey; 3 Histology, Gülhane Military<br />
Medical Faculty, Ankara, Turkey<br />
4609 — A0160 Inflammatory monocytes<br />
accumulate in atrophic age-related macular<br />
degeneration. Sophie Lavalette 1, 2 , S. Camelo 3, 4 ,<br />
O. Levy 1, 2 , W. Raoul 1, 2 , B. Calippe 1, 2 , X. P.<br />
Guillonneau 1, 2 , C. Combadière 5, 6 , F. Sennlaub 1, 2 .<br />
1<br />
INSERM,U968, Paris, France; 2 UPMC Univ Paris<br />
06, UMR_S 968, Institut de la Vision, Paris, France;<br />
3<br />
INSERM, UMR_S 872, Centre de Recherche des<br />
Cordeliers, Paris, France; 4 UPMC Univ Paris 06,<br />
UMR_S 872, Paris, France; 5 INSERM UMR_S<br />
945, Laboratoire d’Immunologie Cellulaire, Paris,<br />
France; 6 UPMC Univ Paris 06, UMR_S 945, Paris,<br />
France<br />
4610 — A0161 Cell growth inhibtion in HPV 18<br />
positive uveal melanoma cells by E6/E7 siRNA.<br />
Xianqun Fan, R. Jia. Ninth People’s Hospital,<br />
Shanghai Jiaotong University School of Medicine,<br />
Shanghai, China<br />
4611 — A0162 Aflibercept is internalized<br />
by retinal microvascular endothelial cells.<br />
Heidrun L. Deissler, G. E. Lang. Department of<br />
Ophthalmology, University of Ulm, Ulm, Germany<br />
*CR<br />
4612 — A0163 Therapeutic Efficacy of Adipose<br />
Stromal Cells to Protect the Retinal Neurons and<br />
Vasculature in Rat Retinal Ischemia-reperfusion<br />
Injury Model. Chandrika Abburi 1 , A. J. Cantor 1 , S.<br />
Caballero 5 , R. Maturi 3, 1 , T. S. Kern 4 , M. B. Grant 5 ,<br />
K. L. March 2 , G. Rajashekhar 1, 2 . 1 Ophthalmology,<br />
Eugene and Marilyn Glick Eye Institute, Indiana<br />
Univ., Indianapolis, IN; 2 Indiana Center for Vascular<br />
Biology & Medicine, Indianapolis, IN; 3 Midwest<br />
Eye Institute, Indianapolis, IN; 4 Ophthalmology,<br />
Case Western Reserve University, Cleveland, OH;<br />
5<br />
Pharmacology and Therapeutics, University of<br />
Florida, Gainesville, FL *CR<br />
4613 — A0164 Lp-PLA 2<br />
is a potential<br />
therapeutic target in diabetic macula edema.<br />
Paul Canning 1 , J. V. Glenn 1 , V. Prise 1 , D. C.<br />
Gale 2 , A. W. Stitt 1 , P. S. Adamson 3 . 1 Centre of<br />
Vision & Vascular Science, Queens University<br />
Belfast, Belfast, United Kingdom; 2 Ophthalmology<br />
Discovery Performance Unit, GlaxoSmithKline,<br />
King of Prussia, PA; 3 Ophthalmology Discovery<br />
Performance Unit, GlaxoSmithKline, Stevenage,<br />
United Kingdom *CR<br />
4614 — A0165 Differential impairment of rod<br />
and cone pathways in streptozotocin-induced<br />
diabetic mice. Ilaria Piano 1 , A. Caputo 2 , E.<br />
Novelli 1 , L. A. Cervetto 2 , C. M. Gargini 2 . 1 IRCCS-<br />
G.B. Bietti Foundation for Ophthalmology<br />
Research, Rome, Italy; 2 Pharmacy, University of<br />
Pisa, Pisa, Italy<br />
4615 — A0166 Comparative Ocular Tissue<br />
Distribution Kinetics of the Visual Cycle<br />
Modulator (VCM) Emixustat-HCl in Rats,<br />
Beagle Dogs, and Cynomolgus Monkeys.<br />
Terry Podoll 1 , S. Al-Fayoumi 1 , E. Prescott 2 , J. W.<br />
Chandler 1 , R. Kubota 1 . 1 Acucela Inc, Seattle, WA;<br />
2<br />
Covance Laboratories Inc, Madison, WI *CR<br />
4616 — A0167 Systemic erythropoietin and its<br />
role in diabetic retinopathy. Sofija Davidovic 1 , S.<br />
Latinovic 2 . 1 Department for vitreoretinal diseases,<br />
University Eye Clinic Clinical Center Vojvodina,<br />
Novi Sad, Serbia; 2 VIDAR ORASIS- Swiss, Private<br />
Eye hospital, Novi Sad, Serbia<br />
4617 — A0168 Chemical Screens in<br />
Zebrafish Identify Novel Inhibitors of Retinal<br />
Neovascularisation in Mouse. Breandan N.<br />
Kennedy 1 , Y. Alvarez 1 , M. Tosetto 2 , C. Kilty 1 , T.<br />
Sasore 1 , C. M. McVicar 3 , A. W. Stitt 3 , J. O’Sullivan 4 ,<br />
A. L. Reynolds 1 . 1 UCD School of Biomolecular<br />
and Biomedical Science & UCD Conway Institute,<br />
University College Dublin, Dublin, Ireland; 2 St.<br />
Vincent’s University Hospital, University College<br />
Dublin, Dublin, Ireland; 3 Centre for Vision and<br />
Vascular Science, Queen’s University, Belfast,<br />
United Kingdom; 4 Department of Surgery, Trinity<br />
College Dublin, Dublin, Ireland *CR<br />
4618 — A0169 Evaluation of Antiangiogenic<br />
Effect of Sintetic Small Fragments of PEDF.<br />
Andrea R. Carvalho, J. Badal, M. A. Zapata, A.<br />
Salas Torras, L. N. Distefano, J. Garcia-Arumi.<br />
Ophthalmology, Inst de Recerca Hosp Vall<br />
d’Hebron, Barcelona, Spain<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
300
<strong>Wednesday</strong> – Posters – 4619 – 4641<br />
4619 — A0170 A novel Erythropoietin-derived<br />
peptide regulates Endothelial Progenitor Cell<br />
(EPC) mediated retinal vasorepair. Olivia E.<br />
O’Leary 1 , E. Reid 1 , C. M. McVicar 1 , M. Brines 2 , A.<br />
Cerami 2 , R. J. Medina 1 , D. P. Brazil 1 , A. W. Stitt 1 .<br />
1<br />
Centre for Vision and Vascular Science, Queen’s<br />
University Belfast, Belfast, United Kingdom;<br />
2<br />
Warren Pharmaceuticals, Ossining, NY *CR<br />
4620 — A0171 Effect of HMG-CoA reductase<br />
inhibitor(statins) on the expression of catalase<br />
in human retinal pigment epithelial cells. Min<br />
Gu Kang, S. Lee, N. Kim, H. Chin. Department<br />
of Ophthalmology and Inha Vision Science<br />
Laboratory, Inha University School of Medicine,<br />
Incheon, Republic of Korea<br />
4621 — A0172 Resveratrol suppresses the<br />
VEGF expression by inhibition of the CXCR4<br />
Expression in ARPE-19 cells. Inyoung Chung 1 , H.<br />
Seong 2 , S. Kang 2 , J. Park 1 , S. Seo 1 . 1 Ophthalmology,<br />
School of Medicine, Institute of Health Sciences,<br />
Gyeongsang National University, Jinju-si,<br />
Republic of Korea; 2 Anatomy and Neurobiology,<br />
School of Medicine, Institute of Health Sciences,<br />
Medical Research Center for Neural Dysfunction,<br />
Gyeongsang National University, Jinju-si, Republic<br />
of Korea<br />
4622 — A0173 Antiangiogenic Effect of<br />
Quercetin on Laser-Induced Choroidal<br />
Neovascularization in Mice. Junichi Fukuhara 1, 2 ,<br />
K. Noda 1, 2 , S. Takashina 1, 2 , Y. Dong 1, 2 , S.<br />
Kinoshita 1, 2 , Z. Dong 1, 2 , R. Ando 1, 2 , A. Kanda 1, 2 ,<br />
S. Ishida 1, 2 . 1 Laboratory of Ocular Cell Biology<br />
and Visual Science, Hokkaido University Graduate<br />
School of Medicine, Sapporo, Japan; 2 Department<br />
of Ophthalmology, Hokkaido University Graduate<br />
School of Medicine, Sapporo, Japan<br />
4623 — A0174 Genistein Suppresses Laser-<br />
Induced Choroidal Neovascularization in Mice.<br />
Satoshi Kinoshita 1, 2 , K. Noda 1, 2 , S. Takashina 1, 2 ,<br />
Y. Dong 1, 2 , J. Fukuhara 1, 2 , Z. Dong 1, 2 , R. Ando 1, 2 ,<br />
A. Kanda 1, 2 , S. Ishida 1, 2 . 1 Laboratory of Ocular<br />
Cell Biology and Visual Science, Hokkaido<br />
University Graduate School of Medicine, Sapporo,<br />
Japan; 2 Department of Ophthalmology, Hokkaido<br />
University Graduate School of Medicine, Sapporo,<br />
Japan<br />
4624 — A0175 Inhibition of Laser-induced<br />
Choroidal Neovascularization by Macrolactin<br />
Compounds. Sang Jin Kim 1 , J. Kim 1 , D. Kim 2 .<br />
1<br />
Ophthalmology, Samsung Medical Center,<br />
Sungkyunkwan University School of Medicine,<br />
Seoul, Republic of Korea; 2 Research and<br />
Development Center, Daewoo Pharm. Co. Ltd.,<br />
Busan, Republic of Korea *CR<br />
4625 — A0176 Inhibition of choroidal<br />
neovascularization by neutralizing PDGF with<br />
a recombinant fusion protein of PDGFR β<br />
domain. Yiwen Li 1 , W. Tao 2 , V. Ling 2 , A. Nystuen 2 ,<br />
S. A. Elliott 2 , P. Stabila 2 , R. Wen 1 . 1 Bascom Palmer<br />
Eye Institute, University of Miami, Miami, FL;<br />
2<br />
Neurotech USA, Lincoln, RI *CR<br />
4626 — A0177 One-year Results of Intravitreal<br />
Ranibizumab Combined with Reduced-Fluence<br />
Photodynamic Therapy for Polypoidal Choroidal<br />
Vasculopathy. Daisuke Yamanouchi, M. Sakurai,<br />
T. Baba, M. Kitahashi, H. Yokouchi, M. Kubota-<br />
Taniai, S. Yamamoto. Chiba univercity, Chiba, Japan<br />
4627 — A0178 NIPAAm Based Cell Delivery<br />
Scaffolds for Posterior Segment Therapeutics.<br />
Ben Muirhead 1 , S. D. Fitzpatrick 1 , K. Gregory-<br />
Evans 2 , M. Bhatia 1 , H. Sheardown 1 . 1 Biomedical<br />
Engineering, McMaster University, Elmira, ON,<br />
Canada; 2 Ophthalmology and Visual Sciences,<br />
University of British Columbia, Vancouver, BC,<br />
Canada *CR<br />
Exhibit Hall B0092-B0137<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Physiology/Pharmacology / Retinal Cell Biology<br />
438 Retinal Flow and VEGF<br />
Moderators: Michele Reibaldi and Tonia S. Rex<br />
4628 — B0092 Subfoveal Choroidal blood<br />
flow in senescence. John V. Lovasik, H. Kergoat,<br />
M. Parent. School of Optometry, University of<br />
Montreal, Montreal, QC, Canada<br />
4629 — B0093 Time-dependent intracellular<br />
pattern of Bevacizumab in RPE cells. Shereen<br />
Hassan M. Aboul Naga 1, 2 , M. Dithmer 1 , J. Roider 1 ,<br />
A. K. Klettner 1 . 1 Ophthalmology, University of<br />
Kiel, University Medical Centre, Kiel, Germany;<br />
2<br />
Ophthalmology, Kasr Al Aini, Cairo University<br />
Hospitals, Cairo, Egypt *CR<br />
4630 — B0094 Antagonism of PDGFRβ<br />
Inhibits Pericyte Recruitment in a Mouse Model<br />
of Corneal Neovascularization. Amy Jensen 1 , R.<br />
Cepeda 1 , M. Maker 1 , C. E. Bigelow 1 , J. Ghosh 1 ,<br />
G. Li 1 , P. A. D’Amore 2 , G. Spohn 1 , B. D. Jaffee 1 , S.<br />
Azarian 1 . 1 Ophthalmology, Novartis, Cambridge,<br />
MA; 2 Ophthalmology, Schepens Eye Research<br />
Institute, Boston, MA *CR<br />
4631 — B0095 Dynamic retinal venous<br />
oscillations are changed in diabetes mellitus<br />
type 1. Konstantin E. Kotliar 1, 2 , I. M. Lanzl 2 , T.<br />
Siegmund 4 , A. Schmidt-Trucksaess 5, 3 . 1 Biomedical<br />
Engineering, Aachen University of Applied<br />
Sciences, Juelich, Germany; 2 Ophthalmology,<br />
Munich University of Technology, Munich,<br />
Germany; 3 Preventive Sports Medicine, Munich<br />
University of Technology, Munich, Germany;<br />
4<br />
Endocrinology and Diabetes, Bogenhausen<br />
Hospital, Munich, Germany; 5 Division of Sports<br />
Medicine, University of Basel, Basel, Switzerland<br />
*CR<br />
4632 — B0096 Parameters related to Choroidal<br />
thickness. Yasuki Ito 1 , K. Oiwa 1 , E. Iwata 1 , A.<br />
Takahashi 1 , T. Yasuma 1 , K. Kawano 1 , N. Hamajima 2 ,<br />
H. Terasaki 1 . 1 Ophthalmology, Nagoya University<br />
Graduate School of Medicine, Nagoya, Japan;<br />
2<br />
Department of Preventive Medicine, Nagoya<br />
University Graduate School of Medicine, Nagoya,<br />
Japan<br />
4633 — B0097 Blockade of PGF/VEGFR1<br />
signaling significantly prevents BRB breakdown,<br />
apoptosis and inflammation in diabetic<br />
retinopathy. Hu Huang, D. Johnson, D. Kim, G. A.<br />
Lutty. Ophthalmology, Johns Hopkins Wilmer Eye<br />
Inst, Baltimore, MD<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
301<br />
4634 — B0098 Computational Model of<br />
Oxygen Transport in Retina and Optic Nerve.<br />
David Bragason 1 , E. Stefánsson 1, 2 . 1 Ophthalmology,<br />
Landspitali University Hospital, Reykjavik, Iceland;<br />
2<br />
Medicine, University of Iceland, Reykjavik,<br />
Iceland *CR<br />
4635 — B0099 Increased Retinal Vascular<br />
Tortuosity in Obstructive Sleep Apnea. Amir<br />
Mohsenin 1 , V. Mohsenin 2 , R. A. Adelman 1 .<br />
1<br />
Department of Ophthalmology, Yale University<br />
School of Med, New Haven, CT; 2 Yale Center<br />
for Sleep Medicine, Yale University School of<br />
Medicine, New Haven, CT<br />
4636 — B0100 Oxygen saturation in<br />
retinal hemorrhages. Olafur Palsson 1, 2 , S. H.<br />
Hardarson 1, 2 , T. S. Eliasdottir 2 , E. Stefánsson 1, 2 .<br />
1<br />
Department of Ophthalmology, Landspítali<br />
University Hospital, Reykjavik, Iceland; 2 University<br />
of Iceland, Reykjavik, Iceland *CR<br />
4637 — B0101 Assessment of Total Retinal<br />
Blood Flow under Systemic Hypercapnia<br />
and Hypocapnia. Ayda M. Shahidi 1 , S. R.<br />
Patel 1 , J. G. Flanagan 1, 3 , O. Tan 2 , D. Huang 2 , C.<br />
Hudson 1, 3 . 1 Ophthalmology & Vision Science,<br />
University Health Network, Toronto, ON, Canada;<br />
2<br />
Ophthalmology, Oregon Health and Science<br />
University, Portland, OR; 3 Optometry & Vision<br />
Science, University of Waterloo, Waterloo, ON,<br />
Canada *CR<br />
4638 — B0102 One-year results of<br />
Central Retinal Sensitivity in eyes treated<br />
with Pegaptanib for Proliferative Diabetic<br />
Retinopathy with extended dosing. Blanca C.<br />
Flores, V. H. Gonzalez, R. Diaz-Rohena. Valley<br />
Retina Institute, McAllen, TX *CR, f<br />
4639 — B0103 Persistent hyaloid vessels<br />
counteract insufficient retinal perfusion in the<br />
mouse eye. Christina Seide, M. Garcia Garrido,<br />
V. Sothilingam, N. Tanimoto, S. C. Beck, M. W.<br />
Seeliger. Div of Ocular Neurodegeneration, Ctr for<br />
Ophthal Inst for Ophth Rsrch, Tuebingen, Germany<br />
4640 — B0104 Retinal Vessel Diameter at<br />
High Altitude. Gabriel Willmann 1 , A. Schatz 1 , M.<br />
Fischer 1, 3 , K. Schommer 2 , E. Zrenner 1 , K. Bartz-<br />
Schmidt 1 , F. Gekeler 1 . 1 Centre for Ophthalmology,<br />
University of Tübingen, Tübingen, Germany;<br />
2<br />
Department of Sports Medicine, University<br />
Hospital Heidelberg, Heidelberg, Germany;<br />
3<br />
Nuffield Laboratory of Ophthalmology, University<br />
of Oxford, Oxford, United Kingdom *CR<br />
4641 — B0105 Retinal and Cerebral<br />
Oxygenation Response to Graded Hypoxia.<br />
Sunni R. Patel 1 , C. Hudson 2, 3 , A. M. Shahidi 1 ,<br />
S. Kulasekara 2 , J. Fisher 4 , J. G. Flanagan 2, 3 , W.<br />
Mutch 5 . 1 Ophthalmology and Vision Sciences,<br />
Toronto Western Hospital, Toronto, ON, Canada;<br />
2<br />
Department of Ophthalmology and Vision<br />
Science, University of Toronto, Toronto, ON,<br />
Canada; 3 School of Optometry and Vision Science,<br />
University of Waterloo, Toronto, ON, Canada;<br />
4<br />
School of Physiology, University of Toronto,<br />
Toronto, ON, Canada; 5 Perioperative Medicine<br />
and Anaesthesiology, University of Manitoba,<br />
Winnepeg, MB, Canada *CR<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm
4642 – 4666 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
4642 — B0106 3-D Computer-Automated<br />
Threshold Amsler Grid to Quantify Retinal<br />
Deficits Before and After Standard Treatment of<br />
Wet Age-related Macular Degeneration. Kristie<br />
Lin 1 , W. Fink 2, 3 , S. Kamjoo 1 , M. Davis 1 , T. Chang 1 .<br />
1<br />
Retina Institute of California, Arcadia, CA;<br />
2<br />
Physics, Mathematics and Astronomy, California<br />
Institute of Technology, Pasadena, CA; 3 Biomedical<br />
Engineering, University of Arizona, Tuscon, AZ<br />
*CR, f<br />
4643 — B0107 Treatment of retinal capillary<br />
hemangioblastoma using inhibitors of the HIF<br />
pathway. Mridul Mukherji, D. Vavilala, P. Swami,<br />
V. Ponnaluri. Pharmacy - Pharmaceutical Sci, Univ<br />
of Missouri - Kansas City, Kansas City, MO<br />
4644 — B0108 Short-term Effects of Cocoa<br />
on Retinal Reactivity in Individuals with<br />
Prediabetes and Type 2 Diabetes. Mary E. Lott 1 ,<br />
A. Johns 1 , J. Oman 1 , J. E. Slocomb 2 , M. Herr 1 ,<br />
R. A. Gabbay 3 , D. A. Quillen 4 , K. Bettermann 2 .<br />
1<br />
Heart and Vascular Institute, Penn State Milton S<br />
Hershey Med Ctr, Hershey, PA; 2 Neurology, Penn<br />
State Milton S Hershey Med Ctr, Hershey, PA;<br />
3<br />
Endocrinology, Penn State Milton S Hershey Med<br />
Ctr, Hershey, PA; 4 Opthalmology, Penn State Milton<br />
S Hershey Med Ctr, Hershey, PA<br />
4645 — B0109 Altered Vascular<br />
Microenvironment by Bevacizumab in<br />
Diabetic Fibrovascular Membrane. Shintaro<br />
Nakao 1 , K. Ishikawa 1 , S. Yoshida 1 , R. Kohno 1 , M.<br />
Miyazaki 1 , H. Enaida 1 , T. Kono 2 , T. Ishibashi 1 .<br />
1<br />
Ophthalmology, Kyushu University, Fukuoka,<br />
Japan; 2 Ophthalmology, Fukuoka University,<br />
Fukuoka, Japan<br />
4646 — B0110 Retinal Oxygenation During<br />
Intravitreal Treatment for Central Retinal Vein<br />
Occlusion. Sindri Traustason, M. D. de La Cour,<br />
M. Larsen. Dept of Ophthalmology,Glostrup Univ<br />
Hosp, Copenhagen University, Glostrup, Denmark<br />
*CR, f<br />
4647 — B0111 Rationale for Bimonthly<br />
Ranibizumab and Quarterly Aflibercept. A Drug<br />
and Disease Assessment Model in Wet Agerelated<br />
Macular Degeneration. Daniele Veritti 1 ,<br />
G. Gorni 2 , L. Perissin 3 , P. Lanzetta 1 . 1 Department of<br />
Ophthalmology, University of Udine, Udine, Italy;<br />
2<br />
Department of Mathematics and Computer Science,<br />
University of Udine, Udine, Italy; 3 Department of<br />
Biomedical Sciences and Technologies, University<br />
of Udine, Udine, Italy *CR<br />
4648 — B0112 Retinal Vein Occlusions in<br />
Young Patients: Visual Outcomes and Associated<br />
Systemic Risk Factors. Noureen Khan 1, 2 , M.<br />
M. Lai 1, 2 . 1 Dept. of Ophthalmology, Georgetown<br />
University/Washington Hospital Center,<br />
Washington, DC; 2 The Retina Group of Washington,<br />
Chevy Chase, MD<br />
4649 — B0113 Effects of Prostacyclin on<br />
Isolated Porcine Retinal Arterioles: Cross-Talk<br />
between Nitric Oxide and Prostacyclin. Shinji<br />
Ono, T. Nagaoka, T. Omae, T. Kamiya, A. Yoshida.<br />
Ophthalmology, Asahikawa Med University,<br />
Asahikawa, Japan *CR<br />
4650 — B0114 Perifoveal Microvasculature<br />
in Human Eyes with Vascular Comorbidities.<br />
Geoffrey Chan 1, 2 , C. Bala 1, 2 , P. Yu 1, 2 , W. Morgan 1 , I.<br />
L. McAllister 1 , S. J. Cringle 1, 2 , Y. Dao-Yi 1, 2 . 1 Centre<br />
for Ophthalmology and Visual Science, Perth, WA,<br />
Australia; 2 Australian Research Council Centre<br />
of Excellence in Vision Science, Canberra, ACT,<br />
Australia *CR<br />
4651 — B0115 Flavonoid-rich dark chocolate<br />
improves endothelial function in retinal<br />
vessels. Naim Terai, A. Gedenk, E. Spoerl, R.<br />
P. Stodtmeister. Ophthalmology, University of<br />
Dresden, Dresden, Germany *CR<br />
4652 — B0116 Inhibition of retinal<br />
neovascularization by luteolin via suppression<br />
of VEGF expression and VEGFR signaling<br />
pathway. Sung Wook Park 1, 2 , C. Cho 1 , H. Jun 1 ,<br />
N. Ryu 3 , J. Kim 1 , Y. S. Yu 1 , J. Kim 3 , J. Kim 1, 2 .<br />
1<br />
FARB, Department of Ophthalmology, Seoul<br />
National University Hospital, Seoul, Republic<br />
of Korea; 2 Biomedical Sciences, Seoul National<br />
University College of Medicine, Seoul, Republic of<br />
Korea; 3 Diabetic Complications Research Center,<br />
Division of Traditional Korean Medicine Integrated<br />
Research, Korea Institute of Oriental Medicine,<br />
Daejeon, Republic of Korea<br />
4653 — B0117 Plasma VEGF-levels are<br />
variable in patients with persistent renal<br />
dysfunction and diabetes: possible implications<br />
and risks for ophthalmic anti-VEGF therapy.<br />
Markus van der Giet, M. Schuchardt, N. Pruefer,<br />
J. Pruefer. Med. Klinik - SP Nephrology, Charite -<br />
Universitätsmedizin Berlin, Berlin, Germany *CR<br />
4654 — B0118 Pathological retinal<br />
neovascularization is exacerbated by selective<br />
pharmacological blockade of VEGFR2, but<br />
ameliorated by combination with Placental<br />
Growth Factor (PlGF) inhibition in the Oxygen<br />
induced Retinopathy (OIR) model in mice.<br />
Eunice Cheung, I. B. Lobov, G. D. Yancopoulos,<br />
S. J. Wiegand. Ophthalmology, Regeneron<br />
Pharmaceuticals, Inc., Tarrytown, NY *CR<br />
4655 — B0119 Treatment of proliferative<br />
idiopathic macular telangiectasia Type 2 with<br />
intravitreal bevacizumab. Ranjit Sandhu, R. D.<br />
Hamilton. Medical Retina, Moorfields Eye Hospital,<br />
London, United Kingdom *CR<br />
4656 — B0120 Computational model of blood<br />
flow through the choriocapillaris highlights<br />
marked heterogeneity of blood flow. Moussa A.<br />
Zouache 1, 2 , P. J. Luthert 1, 2 , I. Eames 3 . 1 Institute<br />
of Ophthalmology, University College London,<br />
London, United Kingdom; 2 NIHR Biomedical<br />
Research Centre in Ophthalmology, London, United<br />
Kingdom; 3 Department of Mechanical Engineering,<br />
University College London, London, United<br />
Kingdom<br />
4657 — B0121 Periocular injection of a broad<br />
spectrum antiangiogenic therapy regresses<br />
choroidal neovascularization. Ofra Benny, Z.<br />
Chi, L. Bazinet, R. J. D’Amato. Boston Children’s<br />
Hospital, Harvard Medical School, Boston, MA<br />
*CR<br />
4658 — B0122 Efficacy and safety of<br />
subconjunctival bevacizumab for recurrent<br />
pterygium. Larissa S. Stival 1 , A. M. Lago 1 , M.<br />
N. Figueiredo 1 , R. G. Bittar 2 , M. L. Machado 1 , J.<br />
J. Nassaralla 2 . 1 Cornea and Refractive Surgery,<br />
Instituto de Olhos de Goiania, Goiania, Brazil;<br />
2<br />
Retina and Vitreous, IOG, Goiania, Brazil f<br />
4659 — B0123 A Treat and Extend Regimen<br />
Using Anti-VEGF Therapies for Central Retinal<br />
Vein Occlusion. Christopher J. Brady, R. Alshareef,<br />
A. J. Witkin, C. D. Regillo. Wills Eye Institute,<br />
Jefferson Univ School of Medicine, Philadelphia,<br />
PA *CR<br />
4660 — B0124 In vitro studies on the<br />
antiangiogenic effects of Pigment Epithelium<br />
Derived Factor and Somatostatin. Anna Salas<br />
Torras, A. R. Carvalho, I. Abasolo, M. A. Zapata,<br />
L. N. Distefano, S. Schwartz, J. Garcia-Arumi.<br />
Ophthalmology, Vall d’Hebron Research Inst,<br />
Barcelona, Spain<br />
4661 — B0125 Our experience with Sequential<br />
treatment of macular oedema from retinal<br />
vascular occlusions with anti-VEGF agents and<br />
Ozurdex. Evangelia Papavasileiou, A. Grixti, V.<br />
Kumar, S. Prasad. Eye Treatment Centre, Arrowe<br />
Park University Hospital, London, United Kingdom<br />
*CR<br />
4662 — B0126 Short Term Ocular Response<br />
of retinal blood flow to intravitreal injection<br />
of bevacizumab (Avastin○R) treatment in eyes<br />
with central retinal vein occlusion. Seung W. Lee.<br />
Ophthalmology, Dongguk Unv, Gyeongju Hosp,<br />
Gyeongju, Republic of Korea<br />
4663 — B0127 The Effect of Diluted Sterile<br />
Penetration Enhancer Solution in Nebulized Mist<br />
and Liquid Drop Forms on Ocular Circulation<br />
in Patients with Diabetic Retinopathy. Lina<br />
Krepste 1 , A. Harris 2 , I. Januleviciene 1 , V. J.<br />
Balciuniene 1 , L. Siaudvytyte 1 , R. Barsauskaite 1 ,<br />
A. L. Gerber 2 , B. Siesky 2 . 1 Eye Clinic, Lithuanian<br />
University of Health Sciences, Kaunas, Lithuania;<br />
2<br />
Eugene and Marilyn Glick Eye Institute, Indiana<br />
University School of Medicine, Indianapolis, IN<br />
*CR, f<br />
4664 — B0128 Measurement of Retinal Blood<br />
Flow Velocity Using a Newly Developed Doppler<br />
Fourier-Domain Optical Coherence Tomography<br />
Instruments in Humans. Akitoshi Yoshida, T.<br />
Nagaoka, T. Tani, E. Sato, T. Yoshioka, K. Sogawa,<br />
S. Nakabayashi. Ophthalmology, Asahikawa<br />
Medical University, Asahikawa, Japan<br />
4665 — B0129 Mechanisms of retinal venous<br />
pulsation inferred from diameter waveforms<br />
analysis. Fabrice Moret 1 , W. Lagreze 2 , C. M.<br />
Poloschek 1, 2 , M. Bach 1 . 1 Sect. Visual Function and<br />
Electrophys, Eye Hospital, University of Freiburg,<br />
Freiburg, Germany; 2 Sect. Neuroophthalmology,<br />
Eye Hospital, University of Freiburg, Freiburg,<br />
Germany *CR<br />
4666 — B0130 Effect of Nitric Oxide on<br />
Increased Retinal Blood Flow in Response to<br />
Flicker Stimuli in Cats. Takafumi Yoshioka, T.<br />
Nagaoka, A. Yoshida. Ophthalmology, Asahikawa<br />
Medical University, Asahikawa, Japan<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
302
<strong>Wednesday</strong> – Posters – 4667 – 4686<br />
4667 — B0131 Measurement Of Retinal<br />
Blood Flow and Retinal Oxygen Tension During<br />
Acute Decreasing Systemic Blood Pressure In<br />
Cats. Tomofumi Tani, T. Nagaoka, T. Yoshioka,<br />
A. Yoshida. Ophthalmology, Asahikawa Medical<br />
University, Asahikawa, Japan<br />
4668 — B0132 Measurement of Retinal<br />
Blood Flow Using a Newly Developed Doppler<br />
Fourier-Domain Optical Coherence Tomography<br />
Instruments in Cats. Taiji Nagaoka, T. Tani, E.<br />
Sato, T. Yoshioka, K. Sogawa, S. Nakabayashi,<br />
A. Yoshida. Ophthalmology, Asahikawa Medical<br />
University, Asahikawa, Japan<br />
4669 — B0133 Development of a prototype of<br />
laser Doppler flowmeter for the measurement<br />
of blood flow of retinal vessels and optic nerve<br />
head tissue in small animals (rats). Marielle<br />
Mentek 1 , C. Chiquet 3, 1 , F. Truffer 2 , M. Bernabei 2 , B.<br />
Mottet 3 , J. Romanet 3 , D. Godin-Ribuot 1 , M. Geiser 2 .<br />
1<br />
INSERM U1042, Grenoble, France; 2 Institute<br />
of system engineering, University of Applied<br />
Sciences of Western Switzerland, Sion, Switzerland;<br />
3<br />
Ophthalmology department, CHU Grenoble,<br />
Joseph Fourier University, Grenoble, France<br />
4670 — B0134 Retinal blood velocity<br />
significantly decreased in rhegmatogenous<br />
retinal detachment and recovered after surgical<br />
treatment in both artery and vein. Hirofumi<br />
Kinoshita, K. Suzuma, M. Uematsu, R. Ueki, T.<br />
Kitaoka. Nagasaki Univ School of Medicine,<br />
Nagasaki, Japan<br />
4671 — B0135 Ocular rigidity as estimated<br />
based on measurement of pulse amplitude using<br />
pneumotonometry and fundus pulse is dependent<br />
on intraocular pressure. Anton B. Hommer 1, 2 ,<br />
G. Garhofer 2 , L. Schmetterer 2 . 1 Krankenhaus<br />
Hera Vienna, Vienna, Austria; 2 Dep.of. Clinical<br />
Pharmacology, University Clinic, Vienna, Austria<br />
*CR<br />
4672 — B0136 Sphingosine 1-phosphate<br />
elicits constriction of isolated porcine retinal<br />
arterioles. Takayuki Kamiya, T. Nagaoka, T. Omae,<br />
S. Ono, A. Yoshida. Asahikawa Medical University,<br />
Asahikawa, Japan *CR<br />
4673 — B0137 Ocular Pulse Amplitude<br />
Waveform Reflects Ventricular Bigeminy<br />
and Aortic Insufficiency. Jean B. Kassem 1, 2 , S.<br />
E. Katz 1, 2 , C. J. Roberts 2, 3 , A. M. Mahmoud 2, 3 ,<br />
R. H. Small 4, 3 , S. V. Raman 5, 3 . 1 Neuro-Orbit-<br />
Oculoplastics, Havener Eye Institute, Columbus,<br />
OH; 2 Ophthalmology, The Ohio State University,<br />
Columbus, OH; 3 Biomedical Engineering, The Ohio<br />
State University, Columbus, OH; 4 Anesthesiology,<br />
The Ohio State University, Columbus, OH;<br />
5<br />
Cardiovascular Medicine, The Ohio State<br />
University, Columbus, OH *CR<br />
Exhibit Hall B0243-B0273<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Nanotechnology and Regenerative Medicine<br />
439 Ocular Nanoimaging,<br />
Nanobiosensors and Nanodiagnostics<br />
Moderators: Yolanda Diebold and Stephen H. Tsang<br />
4674 — B0243 Functional rescue for a full<br />
year after gene therapy in a pre-clinical model<br />
of retinitis pigmentosa. Katherine J. Wert 1, 2 , R. J.<br />
Davis 1 , J. Sancho-Pelluz 1 , C. Lin 1 , S. H. Tsang 1, 3 .<br />
1<br />
Ophthalmology, Columbia University, New York,<br />
NY; 2 Institute of Human Nutrition, Columbia<br />
University, New York, NY; 3 Pathology & Cell<br />
Biology, Columbia University, New York, NY<br />
4675 — B0244 The effect of nano-structural<br />
hydroxyapatite on the biocompatibity of artificial<br />
cornea skirt material in vitro and in vivo. Ying<br />
Dong 1, 2 , L. Wang 2 , J. Yang 3 , Y. Huang 2 , F. Cui 3 .<br />
1<br />
Department of Ophthalmology, First Hospital<br />
Affiliated to Chinese PLA General Hospital,<br />
Beijing, China; 2 Department of Ophthalmology,<br />
Chinese PLA General Hospital, Beijing, China;<br />
3<br />
Department of Material Science and Engineering,<br />
Tsinghua University, Beijing, China<br />
4676 — B0245 Formulation of a Biocompatible<br />
Photopolymerizable Gel to Prevent the<br />
Oxiative Damage of the Crystalline Lens.<br />
Tongalp H. Tezel 1, 2 , Q. Zeng 1 , M. G. O’Toole 3 , A.<br />
S. Gobin 3 . 1 Ophthal & Vis Sciences, University<br />
of Louisville, Louisville, KY; 2 Anatomy and<br />
Neurobiology, University of Louisville, Louisville,<br />
KY; 3 Bioengineering, University of Louisville,<br />
Louisville, KY *CR<br />
4677 — B0246 Efficacy of a novel<br />
bioengineered corneal stroma fabricated by<br />
a new biocompatible cross linker in corneal<br />
stromal disease model. Takeshi Soma 1 , M.<br />
Matsusaki 2 , M. Matsumoto 2 , H. Ajiro 2 , M.<br />
Tsujikawa 1 , R. Hayashi 1 , Y. Oie 1 , M. Akashi 2 , K.<br />
Nishida 1 . 1 Department of Ophthalmology, Osaka<br />
University Graduate School of Medicine, Suita,<br />
Japan; 2 Department of Applied Chemistry, Osaka<br />
University Graduate School of Graduate School of<br />
Engineering, Suita, Japan *CR<br />
4678 — B0247 Feasibility of 2nd Generation<br />
STS Retinal Prosthesis with 49 Channel<br />
Electrode Array in Dogs. Takashi Fujikado 1, 2 , M.<br />
Kamei 2 , H. Sakaguchi 2 , H. Kanda 1 , T. Morimoto 1, 2 ,<br />
K. Nishida 2 , H. Kishima 3 , T. Maruo 3 , K. Osawa 4 ,<br />
M. Ozawa 4 . 1 Applied Visual Science, Osaka<br />
University, Suita, Japan; 2 Ophthalmology, Osaka<br />
University, Suita, Japan; 3 Neurosurgery, Osaka<br />
University, Suita, Japan; 4 Vision Institute, Nidek<br />
Co., Gamagori, Japan *CR<br />
4679 — B0248 Air transport system of oral<br />
mucosal tissue and cell sheets for clinical<br />
trial. Yoshinori Oie 1 , S. Andojo 1 , N. Konno 1 , H.<br />
Takayanagi 2 , T. Nozaki 3 , S. Takeda 3 , T. Soma 1 , M.<br />
Tsujikawa 1 , K. Nishida 1 . 1 Ophthalmology, Osaka<br />
University, Suita, Japan; 2 Translational Research<br />
Center, Tohoku Univeristy, Sendai, Japan; 3 Central<br />
Research Laboratory, Hitachi, Tokyo, Japan *CR<br />
4680 — B0249 Fullerenol Protects RPE cells<br />
from Oxidative-stress Induced Premature<br />
Senescence via Activation of SIRT1. Guo-Tong<br />
Xu 1, 2 , C. Zhuge 1 , J. Xu 2, 3 , J. Zhang 2, 3 , G. Xu 4 ,<br />
L. Chen 2, 3 , X. Liu 2, 3 , H. Xu 2, 3 , L. Lu 2, 3 , W. Li 5 .<br />
1<br />
Laboratory of Clinical Visual Science, Institute of<br />
Health Sciences, Shanghai Institutes for Biological<br />
Sciences, Chinese Academy of Sciences, Shanghai,<br />
China; 2 Ophthal, Regenerativie Med, Tongji Univ<br />
School of Medicine, Shanghai, China; 3 Department<br />
of Regenerative Medicine and Stem Cell Research<br />
Center, Tongji University School of Medicine,<br />
Shanghai, China; 4 Department of Ophthalmology,<br />
Second Affiliated Hospital, Suzhou University,<br />
Suzhou, China; 5 Department of Ophthalmology,<br />
Drexel University College of Medicine,<br />
Philadelphia, PA<br />
4681 — B0250 Reconstruction of Conjunctival<br />
Epithelium with Goblet Cells by Collagen<br />
Vitrigel. Huifang Zhou 1, 2 , Q. Guo 1 , M. Grant 3 , J.<br />
Elisseeff 1 . 1 Translational Tissue Engineering Center,<br />
Wilmer Eye Institute and Biomedical Engineering,<br />
Baltimore, MD; 2 Ophthalmology, Shanghai<br />
Ninth People’s Hospital, Shanghai Jiaotong<br />
University School of Medicine, Shanghai, China;<br />
3<br />
Oculoplastics Division, Ocular and Orbital Trauma<br />
Center, Wilmer Eye Institute, Johns Hopkins School<br />
of Medicine, Baltimore, MD *CR<br />
4682 — B0251 Overall visual performance is<br />
well described by three independent measures<br />
in Argus ® II subjects. Thomas Z. Lauritzen 1 , A.<br />
Das 1, 2 , J. D. Dorn 1 , R. J. Greenberg 1 . 1 Second Sight<br />
Med Products, Inc, Sylmar, CA; 2 Dept. of Physics,<br />
USC, Los Angeles, CA *CR, f<br />
4683 — B0252 Excimer Ablation of Collagen-<br />
Based Corneal Substitutes. Silvia Odorcic 1 , C.<br />
Noel 1 , D. Mitra 1 , D. Priest 1 , S. Taylor 1 , M. Griffith 2 ,<br />
R. Munger 1 , W. Jackson 1 . 1 The Ottawa Hospital,<br />
Ottawa, ON, Canada; 2 Linköping University,<br />
Linköping, Sweden *CR<br />
4684 — B0253 Human retinal progenitor cells<br />
as a tool for retinal repair: establishing cell lines<br />
for clinical study. Petr Y. Baranov 1 , G. Brooke 2 ,<br />
S. Patel 2 , M. J. Young 1 , J. Sinden 2 . 1 Schepens Eye<br />
Research Institute, Boston, MA; 2 ReNeuron Ltd.,<br />
Guildford, United Kingdom *CR<br />
4685 — B0254 Hybrid vitronectin-mimicking<br />
polycaprolactone scaffolds and human retinal<br />
progenitor cell composites. Elodie Lawley 1, 2 , P. Y.<br />
Baranov 1 , M. J. Young 1 . 1 Opthamology, Schepens<br />
Eye Research Institute, Massachusetts Eye and Ear,<br />
an affiliate of Harvard Medical School, Boston,<br />
MA; 2 Exeter Medical School, Exeter, United<br />
Kingdom *CR<br />
4686 — B0255 Stem Cell and Encapsulated<br />
Drug Delivery to the Inner Retina using a Fibrin<br />
Polymer Spray System. Hari Jayaram 1, 2 , M. F.<br />
Jones 2 , R. M. Day 3 , P. B. Cottrill 2 , K. Eastlake 2 , S.<br />
Becker 2 , G. Limb 2 . 1 NIHR Biomedical Research<br />
Centre for Ophthalmology, UCL Institute of<br />
Ophthalmology & Moorfields Eye Hospital NHS<br />
Foundation Trust, London, United Kingdom;<br />
2<br />
Ocular Biology & Therapeutics, UCL Insitute<br />
of Ophthalmology, London, United Kingdom;<br />
3<br />
Applied Biomedical Engineering, University<br />
College London, London, United Kingdom *CR<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
303
4687 – 4709 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
4687 — B0256 A synthetic carrier for cultured<br />
corneal endothelium implantation. Mark<br />
Daniell 1 , K. D. Brown 1 , B. Ozcelik 4 , P. McKelvie 3 ,<br />
H. Zhang 1 , K. Abberton 2 . 1 CERA, Melbourne, VIC,<br />
Australia; 2 The O’Brien Institute, Fitzroy, VIC,<br />
Australia; 3 Anatomical Pathology, St. Vincent’s<br />
Hospital, Melborne, VIC, Australia; 4 Chemical<br />
and Biomolecular Engineering, The University of<br />
Melbourne, Parkville, VIC, Australia<br />
4688 — B0257 Vision Restoration in Mouse<br />
Models of RP using Light-Gated G-Protein<br />
Coupled Receptors. Benjamin Gaub, M. Berry,<br />
J. Levitz, J. G. Flannery, E. Isacoff. UC Berkeley,<br />
Berkeley, CA<br />
4689 — B0258 Connective Tissue Growth<br />
Factor Protein Expression by Müller Cells is<br />
Bipartite as a Function of Substrate Stiffness.<br />
William J. Foster 1, 2 , J. T. Davis 2 . 1 Ophthalmology,<br />
Weill-Cornell Med Coll, Houston, TX; 2 Physics,<br />
The University of Houston, Houston, TX<br />
4690 — B0259 Corneal Stromal Bioequivalents<br />
Secreted on Patterned Silk Substrata by Corneal<br />
Fibroblasts and Stem Cells. Jian Wu 1, 2 , Y. Du 3 , J.<br />
Rnjak-Kovacina 4 , D. Kaplan 4 , J. L. Funderburgh 3 .<br />
1<br />
McGowan Institute for Regenerative Medicine,<br />
University of Pittsburgh School of Medicine,<br />
Pittsburgh, PA; 2 Ophthalmology & Surgery,<br />
University of Pittsburgh School of Medicine,<br />
Pittsburgh, PA; 3 Ophthalmology, University<br />
of Pittsburgh School of Medicine, Pittsburgh,<br />
PA; 4 Biomedical Engineering, Tufts University,<br />
Medford, MA<br />
4691 — B0260 Kinetics of apoptotic death<br />
and oxidative damage in the retina of P23H-1<br />
rats and the protective effects of nanoceria.<br />
Lily L. Wong 1 , S. Seal 3, 4 , J. F. McGinnis 1, 2 .<br />
1<br />
Ophthalmology, University of Oklahoma Health<br />
Sciences Center & Dean McGee Eye Institute,<br />
Oklahoma City, OK; 2 Cell Biology and Oklahoma<br />
Center for Neuroscience, University of Oklahoma<br />
Health Sciences Center, Oklahoma City, OK;<br />
3<br />
Advanced Materials Processing Analysis Center,<br />
University of Central Florida, Orlando, FL;<br />
4<br />
Mechanical Materials Aerospace Engineering,<br />
Nanoscience & Technology Center, University of<br />
Central Florida, Orlando, FL *CR<br />
4692 — B0261 Conversion of human amniotic<br />
mesenchymal cells to retinal neural-like cells in<br />
conditional medium. Yanqing Zhang 1 , H. Wang 2 , J.<br />
Qian 3 . 1 Eye and ENT Hospital of Fudan University,<br />
Shanghai, China; 2 Shanghai Xi Mei Aesthetic and<br />
Plastic Center, Shanghai, China; 3 Eye and ENT<br />
Hospital of Fudan University, Shanghai, China<br />
4693 — B0262 Regulation of Krüppel-like<br />
Transcription Factor (KLF’s) Family Members<br />
Promotes Potent Axon Regeneration in the<br />
Adult Rat Optic Nerve. Yan Wang 1 , A. Apara 1 , M.<br />
Blackmore 2 , D. P. Brown 1 , M. E. LeBlanc 3 , A. E.<br />
Trillo 1 , J. L. Goldberg 1 . 1 Ophthalmology, Bascom<br />
Palmer Eye Institute, Miami, FL; 2 Biomedical<br />
Science, College of health science,Marquette<br />
University, Milwaukee, WI; 3 PIBS, University of<br />
Miami, Miami, FL<br />
4694 — B0263 Positive charged nanoemulsion<br />
enhanced cyclosporine penetrate into cornea<br />
after ocular topical application. Junjie Zhang,<br />
L. Wang, T. Zhou, J. He, H. Xia, H. Zhang. Dpt<br />
of Pharmaceutical Science, Henan Eye Institute,<br />
Henan Eye Hospital, Zhengzhou, China<br />
4695 — B0264 Induction of cytokeratin 3<br />
expression in immortalized human oral mucosal<br />
epithelial cells by the transduction of Pax6.<br />
Yuzuru Sasamoto, R. Hayashi, M. Tsujikawa,<br />
K. Nishida. Ophthalomology, Osaka University<br />
Medical School, Suita, Japan *CR<br />
4696 — B0265 Transplantation of human<br />
retinal progenitor cells into the subretinal space<br />
of mini pigs. Caihui Jiang, X. Wang, M. Zhang.<br />
Ophthal-Schepens Eye Rsrch Inst, Chinese PLA<br />
General Hospital, Beijing, China<br />
4697 — B0266 Controlled Physical Properties<br />
of Stem Cell Scaffolds for Photoreceptor<br />
Regeneration. Kristan Worthington 1, 3 , A. K.<br />
Salem 2 , A. Guymon 1 , B. A. Tucker 3 . 1 Chemical and<br />
Biochemical Engineering, University of Iowa, Iowa<br />
City, IA; 2 Pharmaceutical Science and Translational<br />
Therapeutics, University of Iowa, Iowa City, IA;<br />
3<br />
Institute for Vision Research, University of Iowa,<br />
Iowa City, IA<br />
4698 — B0267 Development of a bioengineered<br />
3D-model of human conjunctiva. Isabel Arranz-<br />
Valsero 1, 2 , L. Garcia-Posadas 1, 2 , A. Fernández 3 , A.<br />
López-García 1, 2 , F. Iglesias 3 , Y. Diebold 1, 2 . 1 Ocular<br />
Surface Group, IOBA-University of Valladolid,<br />
Valladolid, Spain; 2 Networking Research Center on<br />
Bioengineering, Biomaterials and Nanomedicine<br />
(CIBER-BBN), Valladolid, Spain; 3 Human Tissue<br />
Bank, San Francisco Clinic Foundation, León,<br />
Spain<br />
4699 — B0268 Hybrid interphotoreceptor<br />
matrix - poly(caprolactone) scaffolds for<br />
human retinal progenitor cell culture and<br />
differentiation. Michael J. Young 1 , A. Michaelson 2 ,<br />
P. Y. Baranov 1 , R. L. Carrier 2 . 1 Schepens Eye<br />
Research Inst, Massachusetts Eye and Ear, Harvard<br />
Medical School, Boston, MA; 2 Northeastern<br />
University, Boston, MA *CR<br />
4700 — B0269 Differentiation Of Induced<br />
Pluripotent Stem Cells-Derived Neural Crest<br />
Cells Into Corneal Keratocytes In Vivo.<br />
Satoru Yoshida 1 , H. Miyashita 1 , M. Yasuda 1 , E.<br />
Inagaki 1 , K. Tsubota 1 , H. Okano 2 , S. Shimmura 1 .<br />
1<br />
Ophthalmology, Keio University School of<br />
Medicine, Tokyo, Japan; 2 Physiology, Keio<br />
University School of Medicine, Tokyo, Japan *CR<br />
4701 — B0270 Nanoparticle polyethylenimine-<br />
BMP7 Transfection Dose, Anti-fibrotic Efficacy<br />
and Toxicity for the Rabbit Cornea. Chaitasi<br />
Naik 1 , J. T. Rodier 1 , A. Sharma 1 , A. Stallard 1 , A.<br />
Tandon 1 , A. Klibanov 2 , R. R. Mohan 1 . 1 University<br />
of Missouri - Columbia/Mason Eye Institue,<br />
Columbia, MO; 2 Massachusetts Institute of<br />
Technology, Cambridge, MA<br />
4702 — B0271 Myopia control in guinea<br />
pigs with a biomimetic hyaluronic acidbased<br />
hydrogel. Mariana Garcia 1 , A. K. Jha 2 ,<br />
K. E. Healy 2 , C. F. Wildsoet 1 . 1 Vision Science,<br />
University of California, Berkeley, Berkeley, CA;<br />
2<br />
Bioengineering, University of California, Berkeley,<br />
Berkeley, CA<br />
4703 — B0272 Development of an Amniotic<br />
Membrane-Based Cell Scaffold Using Super<br />
Critical CO2 Technology. David O. Zamora 1 , J.<br />
L. Wehmeyer 2 , H. H. Wang 1 , R. J. Christy 2 , A. J.<br />
Johnson 1 . 1 Ocular Trauma, U.S. Army Institute<br />
of Surgical Research, Ft. Sam Houston, TX;<br />
2<br />
Extremity Trauma & Regenerative Medicine,<br />
U.S. Army Institute of Surgical Research, Ft. Sam<br />
Houston, TX<br />
4704 — B0273 pRNA Nanoparticles for<br />
Intraviteal Delivery of siRNA in Mouse Retina.<br />
Dung V. Nguyen 1 , S. Caballero 1 , S. W. Matthews 2 ,<br />
J. W. Verlander 2 , M. E. Boulton 3 , P. Guo 4 , M. B.<br />
Grant 1 . 1 Pharmacology & Therapeutics, University<br />
of Florida, Gainesville, FL; 2 Medicine, University<br />
of Florida, Gainesville, FL; 3 Anatomy and Cell<br />
Biology, University of Florida, Gainesville, FL;<br />
4<br />
Pharmaceutical Sciences, University of Kentucky,<br />
Lexington, KY *CR<br />
Exhibit Hall B0274-B0286<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Eye Movements / Strabismus / Amblyopia /<br />
Neuro-Ophthalmology<br />
440 Strabismus: Treatment Methods<br />
Moderator: Howard S. Ying<br />
4705 — B0274 A comparison of inferior and<br />
medial rectus weakening by the faden procedure.<br />
Karen E. Grove 1, 2 , D. Morrison 2 . 1 Ophthalmology,<br />
Meharry Medical College, Nashville, TN;<br />
2<br />
Ophthalmology, Vanderbilt University, Nashville,<br />
TN *CR<br />
4706 — B0275 Infection Following Strabismus<br />
Surgery; Why Does it Occur and and How<br />
to Prevent it? Donny Suh. Ophthalmology<br />
Department, University of Nebraska, West Des<br />
Moines, IA<br />
4707 — B0276 The role of eye axial length<br />
in planning strabismus surgery. Maria Silvana<br />
Galantuomo, M. Fossarello, A. Cuccu, I. Zucca.<br />
Ophthalmology, University of Cagliari, Cagliari,<br />
Italy<br />
4708 — B0277 A modified transposition<br />
technique of the superior and inferior rectus<br />
muscles in cases with longstanding sixth nerve<br />
palsy to reduce postoperative vertical deviation<br />
and torsion. Ahmed Z. Soliman, A. Decanini, E. D.<br />
Bothun. Ophthalmology, University of Minnesota,<br />
Minneapolis, MN<br />
4709 — B0278 Comparison of Inferior Oblique<br />
Myectomy and Anterior Transposition on<br />
Horizontal Deviation. Tariq S. Alshehri, H. Park.<br />
Wilmer Eye Institute, Baltimore, MD<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
304
<strong>Wednesday</strong> – Posters – 4710 – 4732<br />
4710 — B0279 Combined Resect and Recess<br />
of a Single Rectus Muscle for incomitant<br />
strabismus: review of 10 patients with emphasis<br />
on surgical dosage. Vivek Patel 1 , S. Das 2 .<br />
1<br />
University of Ottawa, Ottawa, ON, Canada; 2 Eye<br />
institute, University of Ottawa, Ottawa, ON, Canada<br />
4711 — B0280 Adjustable-suture strabismus<br />
surgery: A new, removable, sliding noose. Emily<br />
Deschler, K. Irsch, K. Guyton, D. L. Guyton.<br />
Division of Pediatric Ophthalmology & Adult<br />
StrabismusOphthalmology, The Wilmer Eye<br />
Institute, The Johns Hopkins School of Medicine,<br />
Baltimore, MD *CR<br />
4712 — B0281 Medial Rectus Pulley Posterior<br />
Fixation for Divergence excess Intermittent<br />
Exotropia with high AC/A Ratio. Jae Ho Jung 1 ,<br />
H. Choi 2 , J. Lee 1 , S. Cho 1 , J. E. Lee 2 , I. Byon 2 .<br />
1<br />
Ophthalmology, Pusan Nat’l Univ Yangsan<br />
Hospital, Yangsan, Republic of Korea; 2 PNUH,<br />
Busan, Republic of Korea<br />
4713 — B0282 Effect of inferior oblique<br />
weakening surgery on ocular torsion in<br />
congenital superior oblique palsy. Jinho Lee 1 ,<br />
S. Suh 1, 2 , H. Choung 1, 3 , S. Kim 1, 2 . 1 Department of<br />
Ophthalmology, Seounl National University College<br />
of Medicine, Seoul, Republic of Korea; 2 Seoul<br />
Artificial Eye Center, Seounl National University<br />
Hospital Clinical Research Institute, Seoul,<br />
Republic of Korea; 3 Department of Ophthalmology,<br />
Seoul Municipal Government-Seoul National<br />
University Boramae Medical Center, Seoul,<br />
Republic of Korea<br />
4714 — B0283 Superior oblique paralysis:<br />
treatment by the botulinum toxin A compared<br />
to surgical treatment. Abdulaziz Aloreany 1 , F.<br />
Farguette 1 , R. Bordas 1 , G. Saulnier 1 , H. Dalens 1 ,<br />
F. Chiambaretta 1 , H. Nezzar 1, 2 . 1 ophthalmology,<br />
CHU Clermont Ferrand, Clermont ferrand,<br />
France; 2 IGCNC EA 3295, Université d’Auvergne,<br />
Clermont Ferrand, France<br />
4715 — B0284 Correction of accommodative<br />
factor in patients with residual esotropia after<br />
treatment with botulinum toxin for infantile<br />
esotropia. Mario I. Torres Garcia, R. A. Martinez,<br />
M. Acosta Silva, M. A. Najera Covarrubias, K.<br />
Calderon Soto. Estrabismo, Hospital Fundacion<br />
Nuestra Señora de la Luz, Distrito Federal, Mexico<br />
4716 — B0285 The Effect of a Temperature-<br />
Sensitive Poloxamer/Alginate/CaCl2 Mixture<br />
After Strabismus Surgery in a Rabbit Model.<br />
Won Yeol Ryu, H. Jung, Y. Kwon, W. C. Park, H.<br />
Ahn. Department of Ophthalmology, Dong-A<br />
University College of Medicine, Busan, Republic<br />
of Korea<br />
4717 — B0286 Can Tropicamide 1%<br />
Ophthalmic Solution act as a Potential Adjunct<br />
Treatment for Post Concussive Visual and<br />
Ocular Motor Symptoms? Lynn D. Greenspan.<br />
Foundations of Optometric Medicine, Salus<br />
University, Elkins Park, PA<br />
Exhibit Hall C0101-C0125<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Cornea<br />
441 Corneal Development,<br />
Differentiation, Dystrophies, Genetics<br />
Moderator: Mario Matthaei<br />
4718 — C0101 Role of Shp2 Protein<br />
Phosphatase in Mouse Corneal Epithelium<br />
Stratification. Chia-Yang Liu 1 , G. Ng 1 , L. Yeh 2, 1 ,<br />
H. Liu 1 , Y. Zhang 1 , W. W. Kao 1 . 1 Ophthalmology,<br />
Univ of Cincinnati, Cincinnati, OH; 2 Department of<br />
Ophthalmology, Chang-Gung Memorial Hospital,<br />
Linko, Taiwan<br />
4719 — C0102 The homeodomain transcription<br />
factor PITX2 is required to establish correct<br />
cell lineages and angiogenic privilege in the<br />
developing cornea. Philip J. Gage, A. L. Zacharias,<br />
C. Kuang. Ophthal & Vis Science, Univ Michigan-<br />
Kellogg Eye Ctr, Ann Arbor, MI<br />
4720 — C0103 Expression patterns of<br />
angiogenic factors correlate with vascular<br />
patterning of the developing anterior eye.<br />
Sam Kwiatkowski, R. P. Munjaal, P. Y. Lwigale.<br />
Biochemsitry and Cell Biology, Rice University,<br />
Houston, TX<br />
4721 — C0104 Role of Netrin-4 and Laminin<br />
β2 and γ3 Chains in Corneal Development and<br />
Maintenance. Jeremiah Martino 1, 2 , G. Bachay 1, 2 ,<br />
M. A. Dattilo 1, 2 , D. R. Lazzaro 1, 2 , W. J. Brunken 1, 2 .<br />
1<br />
Ophthalmology and Cell Biology, SUNY<br />
Downstate Medical Ctr, Brooklyn, NY; 2 SUNY Eye<br />
Institute, Brooklyn, NY<br />
4722 — C0105 Ocular Manifestations of<br />
X-linked Reticulate Pigmentary Disorder. Kruti<br />
Dajee, H. D. Cavanagh, N. Hogan, L. A. Baker, A.<br />
R. Zinn, V. V. Mootha. Ophthalmology, University<br />
of Texas Southwestern Medical Center, Dallas, TX<br />
*CR<br />
4723 — C0106 Novel CHRLD1 Mutation and<br />
Secondary Glaucoma in Patient with X-Linked<br />
Megalocornea. Xin Gong, J. T. Whitson, V. V.<br />
Mootha. Ophthalmology, UT Southwestern Medical<br />
Center, Dallas, TX *CR<br />
4724 — C0107 An intronic TCF4 tri-nucleotide<br />
repeat expansion associated with Fuchs Corneal<br />
Dystrophy. S. Amer Riazuddin 1 , B. C. Gapsis 1 , N.<br />
Katsanis 2 , J. D. Gottsch 1 . 1 The Wilmer Eye Institute,<br />
Johns Hopkins Univ Sch of Med, Baltimore,<br />
MD; 2 Center for Human Disease Modeling, Duke<br />
University Medical Center, Durham, NC<br />
4725 — C0108 An Investigation of<br />
Mitochondrial Haplogroups in Fuchs<br />
Endothelial Corneal Dystrophy. Yi-Ju Li 1, 2 , M. A.<br />
Minear 2 , J. Rimmler 2 , E. Balajonda 3 , M. A. Hauser 2 ,<br />
R. Allingham 3 , G. K. Klintworth 3, 4 , S. G. Gregory 2 ,<br />
N. A. Afshari 5, 3 . 1 Biostatistics and Bioinformatics,<br />
Duke University Medical Center, Durham, NC;<br />
2<br />
Center for Human Genetics, Medicine, Duke<br />
University Medical Center, Durham, NC; 3 Duke<br />
University Eye Center, Duke University Medical<br />
Center, Durham, NC; 4 Pathology, Duke University<br />
Medical Center, Durham, NC; 5 Shiley Eye Center,<br />
University of California San Diego, San Diego, CA<br />
*CR<br />
4726 — C0109 Impaired mitochondrial<br />
membrane potential in Fuchs endothelial corneal<br />
dystrophy. Cecily E. Hamill 1, 2 , T. Schmedt 1, 2 , Y.<br />
Chen 1, 2 , U. V. Jurkunas 1, 2 . 1 Massachusetts Eye<br />
and Ear Infirmary, Boston, MA; 2 Schepens Eye<br />
Research Institute, Boston, MA *CR<br />
4727 — C0110 Abnormal extracellular matrix<br />
production in corneal endothelial cells from<br />
patients with late-onset Fuchs corneal dystrophy.<br />
Julia M. Wessel, M. Zenkel, U. Schlotzer-<br />
Schrehardt, B. O. Bachmann, T. Tourtas, F. E.<br />
Kruse. Department of Ophthalmology, University of<br />
Erlangen-Nuremberg, Erlangen, Germany<br />
4728 — C0111 Three novel mutations in<br />
COL8A2 gene of Korean patients with Fuchs’<br />
endothelial corneal dystrophy. Kyu-yeon<br />
Hwang 1, 2 , J. Mok 2 , C. Rho 3, 2 , C. Joo 1, 2 . 1 Department<br />
of Ophthalmology & Visual Science, Seoul<br />
St.Mary`s hospital, the catholic university of Korea,<br />
Seoul, Republic of Korea; 2 Catholic Institutes<br />
of Visual Science, The Catholic University of<br />
Korea, Seoul, Republic of Korea; 3 Department<br />
of Ophthalmology & Visual Science, Deajeon St.<br />
Mary`s hospital, The Catholic University of Korea,<br />
Dae-jeon, Republic of Korea<br />
4729 — C0112 Posterior Polymorphous<br />
Corneal Dystrophy 3 Associated with Agenesis<br />
of the Corpus Callosum. Michelle Jang, A. N.<br />
Roldan, R. F. Frausto, A. J. Aldave. Doris Stein,<br />
Cornea Division, Jules Stein Eye Institute, UCLA,<br />
Los Angeles, CA *CR<br />
4730 — C0113 Posterior Polymorphous<br />
Corneal Dystrophy is Associated with Steep<br />
Corneal Curvature. Lydia Ann, R. F. Frausto,<br />
F. Yu, C. K. Nguyen, A. J. Aldave. Jules Stein Eye<br />
Institute (UCLA), Los Angeles, CA *CR<br />
4731 — C0114 Identification of Genetic<br />
Variant Candidates for Posterior Polymorphous<br />
Corneal Dystrophy 1 utilizing Next-Generation<br />
Sequencing. Ricardo F. Frausto, J. Han, A. J.<br />
Aldave. Doris Stein, Cornea Division, Jules Stein<br />
Eye Institute, UCLA, Los Angeles, CA *CR<br />
4732 — C0115 Exclusion of Pathogenic<br />
Promoter Region Variants and Identification of<br />
Novel Nonsense Mutations in ZEB1 in Posterior<br />
Polymorphous Corneal Dystrophy. Pejman<br />
Bakhtiari, R. F. Frausto, A. N. Roldan, C. Wang,<br />
A. J. Aldave. Jules Stein Eye Institue, Los Angeles,<br />
CA *CR<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
305
4733 – 4754 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
4733 — C0116 Identification by whole-exome<br />
next-generation sequencing of coding region<br />
mutations as candidates for posterior amorphous<br />
corneal dystrophy. Jonathan Han, R. F. Frausto,<br />
M. J. Kim, A. J. Aldave. Doris Stein, Cornea<br />
Division, Jules Stein Eye Institute, Los Angeles,<br />
CA *CR<br />
4734 — C0117 Lattice corneal dystrophy,<br />
type 1 (LCD1): an epithelial or stromal entity ?<br />
Walter Lisch 1 , B. Seitz 2 . 1 Ophthalmology, Johannes<br />
Gutenberg University Mainz, Mainz, Germany;<br />
2<br />
Ophthalmology, Saarland University, Homburg/<br />
Saar, Germany<br />
4735 — C0118 Proteolytic processing in lattice<br />
corneal dystrophy. Ebbe Toftgaard Poulsen 1 , K.<br />
Runager 1 , M. W. Risør 1 , I. Thøgersen 1 , T. Dyrlund 1 ,<br />
L. R. Thomsen 1 , G. K. Klintworth 2 , J. J. Enghild 1 .<br />
1<br />
Department of Molecular Biology, Aarhus<br />
University, Aarhus C, Denmark; 2 Departments of<br />
Pathology and Ophthalmology, Duke University,<br />
Durham, NC<br />
4736 — C0119 Benzalkonium chloride<br />
accelerates amyloid fibril formation in corneal<br />
dystrophies in vitro. Yuichi Kaji 1, 2 , H. Yagi 2 ,<br />
Y. Kato 2 , Y. Goto 2 , T. Oshika 1 . 1 Ophthalmology,<br />
University of Tsukuba, Ibaraki, Japan; 2 Laboratory<br />
of Protein Folding, Institute for Protein Research<br />
Osaka University, Osaka, Japan<br />
4737 — C0120 Exploring the mechanism<br />
underlying the protein aggregation in stromal<br />
corneal dystrophies caused by amyloidogenic<br />
and non-amyloidogenic mutants of TGFBIp.<br />
Elavazhagan Murugan 1 , R. Lakshminarayanan 1 , R.<br />
W. Beuerman 1, 2 , S. S. Chaurasia 1 , J. S. Mehta 1, 2 .<br />
1<br />
Tissue engineering and stem cell research group,<br />
Singapore Eye Research Institute, Singapore,<br />
Singapore; 2 Singapore National Eye Centre,<br />
Singapore National Eye Centre, Singapore,<br />
Singapore *CR<br />
4738 — C0121 Insights into the molecular<br />
mechanisms of TGFBIp aggregation in corneal<br />
dystrophies. Kasper Runager 1, 2 , J. Underhaug 1 , C.<br />
S. Sørensen 1, 2 , H. Karring 3 , G. K. Klintworth 4 , N.<br />
C. Nielsen 1 , J. J. Enghild 2, 1 . 1 Center for Insoluble<br />
Protein Structures, Aarhus University, Aarhus,<br />
Denmark; 2 Department of Molecular Biology and<br />
Genetics, Aarhus University, Aarhus, Denmark;<br />
3<br />
Institute of Chemical Engineering, University<br />
of Southern Denmark, Odense M, Denmark;<br />
4<br />
Departments of Pathology and Ophthalmology,<br />
Duke University Medical Center, Durham, NC<br />
4739 — C0122 An inducible transgenic<br />
mouse model of TGFBI-related corneal stromal<br />
dystrophy. Andrew J. Huang 1 , C. Liu 2 , Y. Zhang 2 ,<br />
H. Liu 2 . 1 Ophthalmology & Visual Sciences,<br />
Washington Univ School of Med, St Louis,<br />
MO; 2 Ophthalmology, University of Cincinnati,<br />
Cincinnati, OH<br />
4740 — C0123 Identification of TGFBI gene<br />
mutations in Polish patients with corneal<br />
dystrophies. Monika Udziela 1 , M. Oldak 2, 1 , J.<br />
P. Szaflik 1 , A. Federowicz 2 , R. B. Maksym 2 , R.<br />
Ploski 3 , J. Szaflik 1 . 1 Department of Ophthalmology,<br />
Medical University of Warsaw, Warsaw, Poland;<br />
2<br />
Department of Histology and Embryology,<br />
Medical University of Warsaw, Warsaw, Poland;<br />
3<br />
Department of Medical Genetics, Medical<br />
University of Warsaw, Warsaw, Poland<br />
4741 — C0124 The degree of exacerbated<br />
interfacial opacity after LASIK in Granular<br />
Corneal Dystrophy type 2 is related with the<br />
width of area of granular deposits made before<br />
procedure. Eung Kweon Kim, T. Rim, H. Kim,<br />
T. Kim. Ophthalmology, Yonsei Univ College of<br />
Medicine, Seoul, Republic of Korea<br />
4742 — C0125 shRNA Gene-silencing Therapy<br />
for Congenital Stromal Corneal Dystrophy. Rajiv<br />
R. Mohan, A. Sharma, J. T. Rodier, A. Tandon, D. E.<br />
Birk. Mason Eye Institute, University of Missouri-<br />
Columbia, Columbia, MO<br />
Exhibit Hall D0127-D0181<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Glaucoma<br />
442 Surgery and Wound Healing<br />
Moderator: Tina Wong<br />
4743 — D0127 Prospective evaluation of<br />
medical therapy to prevent the hypertensive<br />
phase following implantation of a glaucoma<br />
drainage device. Helen L. Kornmann, A. Kwong, J.<br />
A. Giaconi, J. Caprioli, S. K. Law. Ophthalmology,<br />
Jules Stein Eye Institute, Los Angeles, CA *CR, f<br />
4744 — D0128 High Intensity Focused<br />
Ultrasound (HIFU) in patients with Refractory<br />
Glaucoma. Shlomo Melamed, M. Goldenfeld, D.<br />
Cotlear, A. Skaat. Goldschleger Eye Institute, Sheba<br />
Medical Center, Ramat Gan, Israel *CR, f<br />
4745 — D0129 Ahmed Glaucoma Valve versus<br />
Gold Micro Shunt (GMS) implants - Five years<br />
Results of a Prospective Randomized Clinical<br />
Trial. Iris Moroz, S. Melamed, O. Sagiv, G. J. Ben<br />
Simon, M. Goldenfeld, A. Skaat. Goldschleger Eye<br />
Institute, Tel Hashomer, Israel *CR, f<br />
4746 — D0130 Graft-free Ahmed valve<br />
implantation through a 6mm scleral tunnel.<br />
Kailun Jiang 1 , G. Gdih 2 . 1 The Ottawa Hospital,<br />
Ottawa, ON, Canada; 2 University of Manitoba,<br />
Winnipeg, MB, Canada<br />
4747 — D0131 The PLGA implant as an<br />
antimitotic delivery system after experimental<br />
trabeculectomy. Ignacio Rodriguez-Agirretxe 1, 2 ,<br />
S. Vega 3 , E. Vecino 4 , J. Mendicute 2 , F. Eder 2 , T.<br />
M. Suarez-Cortes 3 , A. Acera 3 . 1 Glaucoma, ICQO,<br />
Bilbao, Spain; 2 Glaucoma, Donostia Hospital,<br />
San Sebastian, Spain; 3 Bioftalmik SL, Derio,<br />
Spain; 4 Cellular Biology, University of the Basque<br />
Country, Leioa, Spain *CR<br />
4748 — D0132 Corneal Endothelial Cells<br />
Loss After Trabeculectomy For Glaucoma.<br />
Juan A. Dios 1, 2 , M. E. Delgado 2 , V. V. Castro 3 .<br />
1<br />
Ophthalmology, Clinica Ricardo Palma, Lima,<br />
Peru; 2 Ophthalmology, Hospital Alberto Sabogal<br />
Sologuren, Callao, Peru; 3 Ophthalmology, Hospital<br />
Nacional Arzobispo Loayza, Lima, Peru<br />
4749 — D0133 Comparison of surgical<br />
outcomes between 360 degree catheter assisted<br />
and traditional 180 degree trabeculotomy in<br />
patients with congenital glaucoma. Monisha<br />
Mandalaywala Vora 1, 3 , C. H. Marcus 1, 2 , R.<br />
F. Rothman 1, 2 , D. D. Hayes 1, 2 , A. Angelilli 1, 2 .<br />
1<br />
Ophthalmology, North Shore Long Island Jewish<br />
Medical Center, Great Neck, NY; 2 Glaucoma<br />
Consultants of Long Island, Lake Success, NY;<br />
3<br />
Hofstra School of Medicine, Lake Success, NY<br />
4750 — D0134 Long term Intraocular<br />
Pressure Control Using Combined Endoscopic<br />
Cyclophotocoagulation (ECP) And<br />
Phacoemulsification in the Treatment of Mild to<br />
Moderate Glaucoma - 5 Year Results. Michael<br />
J. Siegel 1 , W. Boling 5 , O. S. Faridi 6 , C. K. Gupta 3 ,<br />
M. S. Juzych 1, 2 , M. Citron 3, 4 , M. J. Siegel 3, 4 ,<br />
L. I. Siegel 3, 4 . 1 Ophthalmology, Kresge Eye<br />
Institute, Detroit, MI; 2 School of Medicine, Wayne<br />
State University, Detroit, MI; 3 Ophthalmology,<br />
WIlliam Beaumont Hospital, Royal Oak, MI;<br />
4<br />
Ophthalmology, Glaucoma Center of Michigan,<br />
Southfield, MI; 5 Internal Medicine, Detroit<br />
Medical Center, Detroit, MI; 6 Ophthalmology, Eye<br />
Physicians & Surgeons, PC of Connecticut, Milford,<br />
CT<br />
4751 — D0135 Longitudinal Study of Corneal<br />
Endothelial Damage After Anterior Tube Shunt<br />
Surgery. Koichi Ono 1 , T. Hamanaka 2 , S. Kimura 1 .<br />
1<br />
Department of Ophthalmology, Juntendo Tokyo<br />
Koto Geriatric Medical Center, Juntendo University<br />
School of Medicine, Koto-ku, Japan; 2 Department<br />
of Ophthalmology, Japanese Red Cross Medical<br />
Center, Shibuya-ku, Japan<br />
4752 — D0136 Outcomes of combined<br />
glaucoma tube shunt and fluocinolone acetonide<br />
implant placement in uveitic patients compared<br />
to outcomes in uveitic and open angle glaucoma<br />
patients with glaucoma tube shunt placement<br />
alone. Daniel B. Moore, S. Asrani. Ophthalmology,<br />
Duke Eye Center, Durham, NC<br />
4753 — D0137 The effect of aqueous<br />
humour protein content and viscosity on<br />
equilibrium pressure under the scleral flap in<br />
trabeculectomies. Amir Samsudin 1, 2 , I. Eames 3 , S.<br />
Brocchini 2, 4 , P. T. Khaw 2 . 1 University of Malaya,<br />
Kuala Lumpur, Malaysia; 2 NIHR Biomedical<br />
Research Centre at Moorfields Eye Hospital<br />
NHS Foundation Trust and UCL Institute of<br />
Ophthalmology, London, United Kingdom; 3 UCL<br />
Department of Mechanical Engineering, London,<br />
United Kingdom; 4 UCL School of Pharmacy,<br />
London, United Kingdom *CR<br />
4754 — D0138 Outcomes of Pars Plana<br />
Baerveldt Glaucoma Drainage Implant in Boston<br />
Type 1 Keratoprosthesis Surgery. Eun S. Huh, A.<br />
A. Aref, T. S. Vajaranant, J. De la Cruz, F. Y. Chau,<br />
M. S. Cortina. Ophthalmology, Univ of Illinois Eye<br />
& Ear Infirm, Chicago, IL *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
306
<strong>Wednesday</strong> – Posters – 4755 – 4782<br />
4755 — D0139 The Effect of Trabeculectomy<br />
on Astigmatism. Heleen Delbeke, I. Stalmans, E.<br />
Vandewalle, T. Zeyen. Ophthalmology, University<br />
hospitals Leuven, Leuven, Belgium f<br />
4756 — D0140 Initial Results of Treatment of<br />
Advanced Glaucoma with Ahmed Wing Valve.<br />
Jennifer Oakley 1 , C. Capitena 1 , D. W. Richards 1 , W.<br />
E. Layden 2 . 1 University of South Florida, Tampa,<br />
FL; 2 University Glaucoma Center, Tampa, FL<br />
4757 — D0141 Comparison of the outcomes<br />
of Trabectome with Trabeculotomy with<br />
deep Sclerectomy - Ab Interno vs Ab Externo<br />
approach. Masahiro Maeda 1, 2 , N. Kondo 2 , K.<br />
Onuki 2 , A. Hasegawa 3 . 1 University of California,<br />
Irvine, Irvine, CA; 2 Gifu Red Cross Hospital, Gifu,<br />
Japan; 3 Social Insurance Chukyo Hospital, Nagoya,<br />
Japan<br />
4758 — D0142 Comparison of Surgical<br />
Outcomes of the Ex-PRESS Glaucoma Filtration<br />
Device with Mitomycin C in Phakic and<br />
Pseudophakic Eyes. Sarwat Salim, J. Wan, H. Du.<br />
Ophthalmology, Hamilton Eye Institute, Memphis,<br />
TN *CR<br />
4759 — D0143 Ex-press mini-implant in the<br />
management of ocular hypertension secondary<br />
to silicon oil tamponade. Nicola Cardascia, F.<br />
Cantatore, P. Ferreri, F. Boscia, L. Sborgia, G.<br />
Alessio. Ophthalmology, Università di Bari A Moro,<br />
Bari, Italy<br />
4760 — D0144 Prospective morphological<br />
subconjunctive analysis by spectral domain<br />
optical coherence tomography of blebless<br />
glaucoma surgeries. J. Aritz Urcola 1, 2 ,<br />
C. Dalmasso 1 , J. Cabrerizo 1 , A. Latorre 3 .<br />
1<br />
Ophthalmology, Hospital Universitario Araba,<br />
Vitoria-Gasteiz, Spain; 2 Opthalmology, Begitek<br />
Clínica Oftalmológica, Donostia-San Sebastián,<br />
Spain; 3 Research and development, Hospital<br />
Universitario Araba, Vitoria-Gasteiz, Spain<br />
4761 — D0145 Refractive outcome after<br />
phacoemulsification following trabeculectomy.<br />
Oliver L. Yeh, P. P. Chen. Ophthalmology,<br />
University of Washington, Seattle, WA *CR<br />
4762 — D0146 Long Term Outcomes<br />
of Filtration Surgery for Normal-Tension<br />
Glaucoma with Visual Field Progression at Low<br />
Intraocular Pressure. Scott K. Schultz, S. M.<br />
Iverson, W. Shi, J. C. Schiffman, D. S. Greenfield.<br />
Ophthalmology, Bascom Palmer Eye Institute, Palm<br />
Beach Gardens, FL *CR<br />
4763 — D0147 Corneal Endothelial Cell<br />
Density and Filtration Surgery in Patients with<br />
Posner-Schlossman Syndrome. Yuko Maruyama 1 ,<br />
K. Mori 1 , M. Ueno 1 , Y. Ikeda 1 , K. Maruyama 2 , S.<br />
Kinoshita 1 . 1 Ophthalmology, Kyoto Prefectural<br />
Univ of Med, Kyoto, Japan; 2 Ophthalmology,<br />
Tohoku University Graduate School of Medicine,<br />
Sendai, Japan *CR<br />
4764 — D0148 A Comparison of Sequential<br />
Glaucoma Drainage Device Implantation versus<br />
Cyclophotocoagulation Following Failure of<br />
a Primary Drainage Device. Joshua Levinson,<br />
A. Giangiacomo, A. D. Beck, P. B. Pruett, A.<br />
Costarides. Ophthalmology, Emory University,<br />
Atlanta, GA<br />
4765 — D0149 Retrobulbar Shunt (RS) for<br />
Encapsulated Blebs. Sylvia L. Groth 1 , W. E.<br />
Sponsel 2 . 1 University of Minnesota Medical School,<br />
Minneapolis, MN; 2 University of Texas - San<br />
Antonio, Biomedical Engineering; WESMDPA<br />
Glaucoma Service, San Antonio, TX *CR<br />
4766 — D0150 The outcome of two different<br />
tube ligation methods in Baerveldt implant<br />
surgery. Shuri Kawamorita 1 , T. Hamanaka 1 , T.<br />
Sakurai 2 . 1 Japanese Red Cross Medical Center,<br />
Tokyo, Japan; 2 Tokyo University of Science Suwa,<br />
Nagano, Japan<br />
4767 — D0151 Tube Shunt versus<br />
Trabeculectomy Surgery in Patients with<br />
Glaucoma Associated with Ocular Inflammation.<br />
Cecilia S. Lee, A. Y. Lee, A. Bhorade, H. Karacal.<br />
Ophthalmology, Washington University in St.<br />
Louis, St. Louis, MO *CR<br />
4768 — D0152 Foreign Body Reaction in<br />
Glaucoma Drainage Implant Surgery. Kyoung In<br />
Jung, C. Park. Department of Ophthalmology and<br />
Visual Science, Seoul St. Mary’s Hospital,College<br />
of Medicine, The Catholic University of Korea,<br />
Seoul, Republic of Korea<br />
4769 — D0153 An Engineering Model for<br />
Predicting the Aqueous Humor Flow Rate<br />
through the Natural Pathway Following<br />
Glaucoma Surgeries. Joseph Nelly Sugu Sugira,<br />
M. J. Rickard. College of Engineering, California<br />
Baptist University, Riverside, CA<br />
4770 — D0154 Tube Exposures in Glaucoma<br />
Drainage Devices. Paramdeep S. Mand, P. P. Chen,<br />
M. A. Slabaugh. Ophthalmology, University of<br />
Washington, Seattle, WA *CR<br />
4771 — D0155 The Effect of Adjuvant<br />
Mitomycin C in Ahmed Glaucoma Valve Surgery<br />
For Refractory Glaucoma. Melissa Tien, L. W. Yip,<br />
E. Wong, V. Yong, H. Wong, B. Lim. Ophthalmology,<br />
National Healthcare Group Eye Institute, Tan Tock<br />
Seng Hospital, Singapore, Singapore f<br />
4772 — D0156 Repairing filtration bleb<br />
leakage with FocalSeal ® in rabbit model. Tatsuo<br />
Nagata 1 , Y. Harada 1 , H. Kondo 1 , M. Arai 2, 3 ,<br />
A. Tawara 1 . 1 Ophthalmology, University of<br />
Occupational and Environmental Health, Japan,<br />
Fukuoka, Japan; 2 Arai Eye Clinic, Fukuoka, Japan;<br />
3<br />
Schepens Eye Research Institute, Harvard Medical<br />
School, Boston, MA<br />
4773 — D0157 Ultrasound biomicroscopy<br />
findings after suprachoroidal cypass implant for<br />
glaucoma: one year follow-up. Elisa Gonzalez<br />
Pastor, M. C. Bermudez, L. Morales-Fernandez,<br />
J. M. Martinez de la Casa, J. Garcia-Feijoo.<br />
Glaucoma, Hospital Clinico San Carlos, madrid,<br />
Spain *CR<br />
4774 — D0158 Complementary effects of<br />
bevacizumab and MMC in the improvement<br />
of surgical outcome after glaucoma filtration<br />
surgery. Tine Van Bergen 1 , K. P. Hollanders 1 , D.<br />
Sijnave 1 , S. Van de Velde 1 , E. Vandewalle 1 , L. K.<br />
Moons 2 , I. Stalmans 1 . 1 Lab of Ophthalmology, KU<br />
Leuven, Leuven, Belgium; 2 Department of Biology,<br />
Zoological Institute, KU Leuven, Leuven, Belgium<br />
*CR<br />
4775 — D0159 Ultrasonic Circular Cyclo<br />
Coagulation in patients with Primary Open-<br />
Angle Glaucoma: a Multicenter Clinical<br />
Trial. Florent Aptel 1 , P. Denis 2 , J. J. Rouland 3 ,<br />
J. Nordmann 4 , Y. M. Lachkar 5 , J. G. Renard 6 , E.<br />
Sellem 7 , C. Baudouin 4 , A. M. Bron 8 . 1 Grenoble<br />
University Hospital, Grenoble, France; 2 Hôpital de<br />
la Croix-Rousse, Hospices Civils de Lyon, Lyon,<br />
France; 3 Hôpital Claude Huriez, CHRU de Lille,<br />
Lille, France; 4 Centre Hospitalier National des<br />
Quinze-Vingts, Paris, France; 5 Institut du glaucome,<br />
Fondation Hôpital Saint-Joseph, Paris, France;<br />
6<br />
Hôpital d’Instruction des Armées du Val de Grâce,<br />
Paris, France; 7 Centre Ophtalmologique Kléber,<br />
Lyon, France; 8 Dijon University Hospital, Dijon,<br />
France *CR, f<br />
4776 — D0160 The Effect of Early Post-op<br />
Anti-Hypertensive Agents on the Hypertensive<br />
Phase following Ahmed FP 7 Glaucoma Valve<br />
Implantation, a Retrospective Review. Brenton<br />
Finklea, A. Gupta, S. M. Johnson. Ophthalmology,<br />
University of Virginia, Charlottesville, VA *CR<br />
4777 — D0161 A comparative study of<br />
combined trabeculectomy with ECCE/PCIOL<br />
versus Ex-press Shunt with ECCE/PCIOL.<br />
Farvah Fatima 1, 2 , B. A. Hughes 1, 2 , R. Momi 1, 2 ,<br />
J. Tannir 1, 2 , M. S. Juzych 1, 2 , C. Kim 1, 2 , M. H.<br />
Peracha 1, 2 , A. M. Eby 1, 2 , M. McQueen 1, 2 . 1 Wayne<br />
State University School of Medicine, Detroit, MI;<br />
2<br />
Kresge Eye Institute, Detroit, MI<br />
4778 — D0162 Efficacy and Safety of<br />
Intracameral Triesence Use in Glaucoma<br />
Surgery. Michael Koval, M. R. Moster, K. B.<br />
Freidl, M. J. Pro, J. S. Myers. Glaucoma, Wills Eye<br />
Institute, Philadelphia, PA *CR, f<br />
4779 — D0163 Acute Intra-ocular Pressure<br />
(IOP) Changes Following Cataract Surgery<br />
With and Without Trabectome Ab-interno<br />
Trabeculectomy. Asher Weiner 1 , Y. Weiner 2 .<br />
1<br />
Ophthalmic Consultants of the Capital Region,<br />
Albany, NY; 2 Undergraduate, University of<br />
Michigan, Ann-Arbor, MI<br />
4780 — D0164 Patients presenting with severe<br />
glaucomatous visual field defect benefit from<br />
both surgical and medical treatment. Eugenio<br />
J. Maul de la Puente, J. A. Tapia, A. Kastner.<br />
Ophthalmology, Universidad Catolica, Santiago,<br />
Chile<br />
4781 — D0165 Experience in the Use of<br />
the Express Device Without Mytomicin C in<br />
Patients With Primary Open Angle Glaucoma.<br />
Cristina G. Isida Llerandi, H. Bello Lopez Portillo,<br />
R. Castañeda Diez, M. García-Huerta, F. Gil<br />
Carrasco, J. Jimenez-Roman, M. Turati-Acosta, L.<br />
A. ZARATE. Glaucoma, Asociación para Evitar la<br />
Ceguera en México, Coyoacan, Mexico<br />
4782 — D0166 Investigation of the filtration<br />
surgery with FocalSeal ® in rabbit’s eyes. Yukinori<br />
Harada 1 , T. Nagata 1 , M. Arai 2, 3 , A. Tawara 1 .<br />
1<br />
Department of Ophthalmology, University of<br />
Occupational & Environmental Health, Kitakyushu,<br />
Japan; 2 Arai Eye Clinic, Fukuoka, Japan; 3 Schepens<br />
Eye Research Institute, Harvard Medical School,<br />
Boston, MA<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
307
4783 – 4805 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
4783 — D0167 Long-term results after Ahmed<br />
glaucoma valve implantation for different types<br />
of glaucoma. Olga Furashova, K. R. Pillunat, E.<br />
Spoerl, L. E. Pillunat. Ophthalmology, University<br />
Hospital, Dresden, Germany f<br />
4784 — D0168 Efficacy of Goniosynechialysis<br />
for Chronic Angle-Closure Glaucoma. Guoping<br />
Qing, D. Mou. Beijing Tongren Eye Center, Beijing<br />
Tongren Hospital, Beijing, China f<br />
4785 — D0169 Imaging of Surgical Blebs<br />
using Spectral Domain Optical Coherence<br />
Tomography. Giovanni Milano 1, 2 , M. Raimondi 1, 2 ,<br />
S. Lanteri 1, 2 , S. Lombardo 1, 2 , A. Verticchio<br />
Vercellin 1, 2 , C. Cutolo 1, 2 , L. Bossolesi 2, 1 , G. C.<br />
Rossi 2, 1 . 1 University Eye Clinic, University of<br />
Pavia, Pavia, Italy; 2 Fondazione IRCCS Policlinico<br />
San Matteo, pavia, Italy *CR<br />
4786 — D0170 Fibrovascular ingrowth - a<br />
common cause of Glaucoma Drainage Device<br />
failure in refractory pediatric glaucoma. Irene<br />
Tung, I. Marcus, W. Thiamthat, E. Dosunmu, S. F.<br />
Freedman. Duke Eye Center, Durham, NC *CR<br />
4787 — D0171 Association of Aqueous<br />
Humor Dynamic Markers in Glaucoma With<br />
Canaloplasty Surgery. David M. Reed, J. L.<br />
Gilbert, S. E. Moroi. Ophthalmology & Visual<br />
Sciences, University of Michigan, Ann Arbor, MI<br />
*CR<br />
4788 — D0172 The effect of the Hydrus<br />
trabecular shunt on endothelial cell count: a<br />
double blind prospective randomized clinical<br />
study. Antonio M. Fea, G. Consolandi, G. Pignata,<br />
P. Cannizzo, M. Dal Vecchio, F. Gallozzi, C. Lavia,<br />
T. Rolle, F. M. Grignolo. Ophth/I Clinica Oculistica,<br />
Universita di Torino, Torino, Italy *CR, f<br />
4789 — D0173 Comparison short term post<br />
operative hypotony rates of 23 gauge versus 25<br />
gauge needle size in the formation of a corneascleral<br />
track for Baerveldt tube insertion into the<br />
anterior chamber. Kirithika Muthusamy, J. Cheng,<br />
K. Barton, K. Lim, L. Beltran-Agullo. Glaucoma,<br />
Moorfields Eye Hospital, London, United Kingdom<br />
*CR<br />
4790 — D0174 IOP-lowering and Safety<br />
Associated with Opening Gold Micro Shunt’s<br />
Windows. Nicolas Cadet, P. Harasymowycz.<br />
Ophthalmology, Universite de Montreal, Montreal,<br />
QC, Canada *CR<br />
4791 — D0175 Persistent hypotony associated<br />
to the use of immunosuppressive therapy in<br />
glaucoma drainage implants. Susana Duch,<br />
O. Stirbu, E. Milla, O. Buchacra Castellano.<br />
Ophthalmology- Glaucoma, Institut Condal<br />
d’Oftalmologia, Barcelona, Spain<br />
4792 — D0176 Retrospective review of<br />
patients with refractory glaucoma treated with<br />
Transcleral Diode Laser Cyclophotocoagulation.<br />
Vikas Tah 2 , S. Pasu 1 , S. Shah 1 . 1 Glaucoma, St Helier<br />
Hospital, London, United Kingdom; 2 Oxford Eye<br />
Hospital, Harrow, United Kingdom<br />
4793 — D0177 Comparison of IOP and<br />
postoperative complications in patients<br />
undergoing tube shunt or trabeculectomy<br />
surgery for uveitis-related intraocular pressure<br />
elevation. Umair Iqbal, M. Bal, R. R. Buhrmann,<br />
C. C. Gottlieb. University of Ottawa Eye Institute,<br />
Ottawa, ON, Canada *CR<br />
4794 — D0178 Comparison between<br />
Endhotelial Cell Loss After MICS Phaco<br />
with ExPress Implant and MICS Phaco Safe-<br />
Trabeculectomy. Romeo Altafini, S. Morselli.<br />
Ophthalmology Unit, San Bassiano Hosp, Bassano<br />
del Grappa, Vicenza, Italy<br />
4795 — D0179 The relationship between<br />
skin phototype and trabeculectomy outcome.<br />
Jonathan C. Clarke 1, 2 , M. Lee 1, 3 , A. Khalili 2 , S.<br />
Dhingra 1, 2 , C. Bunce 2 , P. T. Khaw 1, 2 . 1 Glaucoma<br />
Service, Moorfields Eye Hospital, London, United<br />
Kingdom; 2 NIHR Biomedical Research Centre<br />
for Ophthalmology, Moorfields Eye Hospital and<br />
UCL Institute of Ophthalmology, London, United<br />
Kingdom; 3 Kuala Lumpur Hospital, Kuala Lumpur,<br />
Malaysia *CR<br />
4796 — D0180 Rosmarinic Acid Suppresses<br />
Responses By Fibroblasts Contributing To<br />
Fibrosis Following Glaucoma Filtration<br />
Surgery. Jayter S. Paula 1 , C. Modulo 1 , M. C.<br />
Frade 2 , P. Reinach 1 , E. M. Rocha 1 . 1 Department<br />
of Ophthalmology, FMRP - USP, Ribeirao Preto,<br />
Brazil; 2 Internal Medicine Department, FMRP -<br />
USP, Ribeirao Preto, Brazil<br />
4797 — D0181 Incidence and success rates<br />
of trabeculectomy with ExPress mini shunt<br />
following failed canaloplasty. Jacob W. Brubaker,<br />
M. A. Khaimi. Ophthalmology, Dean McGee Eye<br />
Institute, University of Oklahoma, Oklahoma City,<br />
OK *CR<br />
Exhibit Hall D0237-D0291<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Glaucoma<br />
443 Imaging III, GL<br />
Moderators: Christopher K. Leung and<br />
Larry Kagemann<br />
4798 — D0237 Glaucoma progression detection<br />
using a Bayesian-fuzzy logic approach applied<br />
to 3D spectral domain optical coherence<br />
tomography optic nerve head images. Akram<br />
Belghith, C. Bowd, R. N. Weinreb, A. J. Tatham, A.<br />
Miki, F. A. Medeiros, L. M. Zangwill. Department of<br />
Ophthalmology-0946, Hamilton Glaucoma Center,<br />
La Jolla, CA *CR<br />
4799 — D0238 Changes in Anterior Segment<br />
Morphology after Laser Iridotomy in Asian<br />
Indian Eyes: A Source Swept Anterior Segment<br />
Optical Tomography Study. Rajesh Sasikumar, T.<br />
Patil, S. A. Devi, D. Rao, R. Balu, N. K. Puttaiah,<br />
B. K. Shetty. Glaucoma and Research, Narayana<br />
Nethralaya, Bangalore, India<br />
4800 — D0239 Intersubject correlation<br />
between circumpapillary distribution of retinal<br />
nerve fiber layer and retinal vessels: comparison<br />
between optical coherence tomography and<br />
scanning laser polarimetry. Ivania Pereira 1 , S.<br />
Holzer 1 , H. Resch 1 , B. Kiss 1 , G. Fischer 2 , C. Vass 1 .<br />
1<br />
Ophthalmology & Optometry, Medical University<br />
Vienna, Vienna, Austria; 2 Center for Medical<br />
Statistics Informatics and Intelligent Systems,<br />
Section for Medical Information Management<br />
and Imaging, Medical University Vienna, Vienna,<br />
Austria<br />
4801 — D0240 Topographic Correlation<br />
between Ganglion Cell-Inner Plexiform Layer<br />
and Circumpapillary Retinal Nerve Fiber<br />
Layer Defect using Spectral Domain Optical<br />
Coherence Tomography. Ki Ho Park 1, 2 , K. Kim 1, 2 ,<br />
J. Jeoung 1, 2 , S. Kim 1, 3 , D. Kim 1, 2 . 1 Ophthalmology,<br />
Seoul National University College of Medicine,<br />
Seoul, Republic of Korea; 2 Ophthalmology, Seoul<br />
National University Hospital, Seoul, Republic<br />
of Korea; 3 Ophthalmology, SMG-SNU Boramae<br />
Medical Center, Seoul, Republic of Korea<br />
4802 — D0241 Detecting Glaucomatous<br />
Structural Changes in Glaucoma Suspect Eyes<br />
Using a Cohort of Stable Glaucoma Patients.<br />
Naama Hammel 1 , L. M. Zangwill 1 , A. Miki 1 , S. Jain 2 ,<br />
F. He 2 , N. Khachatryan 1 , J. M. Liebmann 3, 4 , C. A.<br />
Girkin 5 , F. A. Medeiros 1 , R. N. Weinreb 1 . 1 Hamilton<br />
Glaucoma Center, Department of Ophthalmology,<br />
University of California, San Diego, La Jolla, CA;<br />
2<br />
Department of Family and Preventive Medicine,<br />
University of California, San Diego, La Jolla, CA;<br />
3<br />
New York University School of Medicine, New<br />
York, NY; 4 Department of Ophthalmology, Einhorn<br />
Clinical Research Center, New York Eye and Ear<br />
Infirmary, New York, NY; 5 School of Medicine,<br />
University of Alabama, Birmingham, AL *CR, f<br />
4803 — D0242 Evaluation of retinal nerve fiber<br />
layer retardation, thickness and birefringence<br />
along the major nerve fiber bundles measured<br />
with polarization sensitive OCT. Stefan Zotter 1 ,<br />
M. Pircher 1 , T. Torzicky 1 , B. Baumann 1 , P. K.<br />
Roberts 2, 1 , I. Pereira 2 , S. Holzer 2 , C. Vass 2 , U.<br />
Schmidt-Erfurth 2 , C. K. Hitzenberger 1 . 1 Center<br />
for Med. Phys. and Biomed. Eng., Medical<br />
University of Vienna, Vienna, Austria; 2 Department<br />
of Ophthalmology and Visual Sciences, Medical<br />
University of Vienna, Vienna, Austria *CR<br />
4804 — D0243 In-Vivo Microstructural<br />
Anatomy of Parapapillary Atrophy: Beta-Zone<br />
and Gamma- Zone. Yi Dai 1 , J. B. Jonas 2 , H.<br />
Huang 1 , M. Wang 1 , X. Sun 1 . 1 Ophthalmology, EYE<br />
& ENT Hospital, Shanghai, China; 2 Ophthalmology,<br />
Medical Faculty Mannheim of the Ruprecht-Karls-<br />
University, Heidelberg, Germany *CR<br />
4805 — D0244 Comparison of birefringencerelated<br />
data between scanning laser polarimetry<br />
(GDx) and polarization sensitive optical<br />
coherence tomography (PS-OCT). Clemens<br />
Vass 1 , I. Pereira 1 , S. Zotter 2 , S. Holzer 1 , H.<br />
Resch 1 , M. Pircher 2 , C. K. Hitzenberger 2 . 1 Dept<br />
of Ophthalmology, Medical University of Vienna,<br />
Vienna, Austria; 2 Center for Medical Physics and<br />
Biomedical Engineering, Medical University of<br />
Vienna, Vienna, Austria *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
308
<strong>Wednesday</strong> – Posters – 4806 – 4827<br />
4806 — D0245 Agreement between Clinical<br />
versus Automated Disc Damage Likelihood<br />
Scalw (DDLS) Staging in Asian Indian eyes.<br />
Premnath Gnaneswaran, S. A. Devi, R. Balu,<br />
D. Rao, N. K. Puttaiah, R. Shetty, R. Sasikumar.<br />
Glaucoma, Narayana Nethralaya, Bangalore, India<br />
4807 — D0246 Multiple linear regression<br />
analysis between circumpapillary retinal nerve<br />
fiber layer thickness profiles measured with<br />
scanning laser polarimetry and retinal blood<br />
vessel thickness, optic disc parameters and age.<br />
Hemma Resch 1 , I. Pereira 1 , S. Holzer 1 , B. Kiss 1 , G.<br />
Fischer 2 , C. Vass 1 . 1 Ophthalmology and Optometry,<br />
Medical Universitiy of Vienna, Austria, Vienna,<br />
Austria; 2 Center for Medical Statistics Informatics<br />
and Intelligent Systems, Section for Medical<br />
Information Management and Imaging, Medical<br />
Universitiy of Vienna, Austria, Vienna, Austria<br />
4808 — D0247 Influence of Anterior Segment<br />
Biometric Parameters on the Anterior Chamber<br />
Angle Width in Eyes with Angle Closure and<br />
Open Angle. Takaaki Matsuki 1, 2 , F. Hirose 1, 2 ,<br />
T. Kameda 1, 2 , Y. Hirami 1, 2 , Y. Kurimoto 1, 2 .<br />
1<br />
Ophthalmology, Kobe City Medical Center General<br />
Hospital, Kobe, Japan; 2 Ophthalmology, Inst of<br />
Biomed Research and Innovation, Kobe, Japan *CR<br />
4809 — D0248 Scan quality can affect<br />
Scanning Laser Polarimetry outcomes. Alice<br />
Chandra Verticchio Vercellin 1, 2 , G. Milano 1, 2 , S.<br />
Lombardo 1, 2 , M. Raimondi 1, 2 , S. Lanteri 1, 2 , C.<br />
Cutolo 1, 2 , L. Bossolesi 2, 1 , G. C. Rossi 2, 1 . 1 University<br />
of Pavia, Pavia, Italy; 2 Policlinico San Matteo<br />
Pavia, Pavia, Italy *CR<br />
4810 — D0249 A New Marker for Detecting<br />
Retinal Ganglion Cell Apoptosis. Jacky Man<br />
Kwong Kwong 1 , C. Hoang 1 , R. M. Torrevillas 1 , J.<br />
Caprioli 1 , R. W. Yee 2 , B. D. Gray 3 , J. A. Mattis 3 ,<br />
K. Y. Pak 3 . 1 Ophthalmology, Jules Stein Eye<br />
Institute, UCLA, Los Angeles, CA; 2 Cizik Eye<br />
Clinic, University of Texas, Health Science Center,<br />
Houston, TX; 3 Molecular Targeting Technologies,<br />
Inc., West Chester, PA *CR<br />
4811 — D0250 Pupil-based detection of<br />
asymmetric glaucomatous damage - comparison<br />
of the Konan RAPDx pupillograph, swinging<br />
flashlight method, and magnifier-assisted<br />
swinging flashlight method. Mohsin Ali 1, 2 , L. Lu 1 ,<br />
P. Martinez 1 , B. M. Faria 1 , L. Gupta 1 , A. Zhang 1, 2 ,<br />
E. Hwang 1 , M. R. Moster 1 , G. L. Spaeth 1 . 1 Glaucoma<br />
Service, Wills Eye Institute, Philadelphia, PA;<br />
2<br />
Jefferson Medical College, Philadelphia, PA *CR<br />
4812 — D0251 Effect of Laser Peripheral<br />
Iridotomy on Trabecular-Iris Surface Area Over<br />
360 Degrees in Primary Angle Closure. Donna<br />
Nguyen 1 , N. P. Bell 1, 2 , L. S. Blieden 1, 2 , L. A. Baker 2 ,<br />
A. Z. Chuang 1 , R. M. Feldman 1, 2 . 1 Ophthalmology<br />
and Visual Science, The University of Texas Health<br />
Science Center at Houston, Houston, TX; 2 Robert<br />
Cizik Eye Clinic, Houston, TX *CR<br />
4813 — D0252 The Prevalence of Spectral<br />
Domain Optical Coherence Tomography Artifact<br />
Patterns in Different Subtypes of Open Angle<br />
Glaucoma and Normal Eyes. Neda Baniasadi,<br />
E. I. Paschalis, T. C. Chen. Ophthalmology,<br />
Massachusetts Eye & Ear Infirmary/Harvard<br />
Medical School, Boston, MA<br />
4814 — D0253 Evaluation of segmented<br />
macular scans by spectral domain optical<br />
coherence tomography in glaucoma. Maxime<br />
Delbarre, H. El Chehab, M. Francoz, J. Fenolland,<br />
M. Marie, J. Giraud, F. May, J. G. Renard.<br />
Department of Ophthalmology, Hopital du Val-de-<br />
Grâce, Paris, France<br />
4815 — D0254 A Novel Technology to Detect<br />
and Visualize Macular Retinal Nerve Fiber<br />
Layer (RNFL) Loss in Glaucoma Using Spectral<br />
Domain Optical Coherence Tomography. Laura<br />
de Polo 1, 2 , A. Invernizzi 1 , M. Cozzi 1 , M. Blini 1 , G.<br />
Staurenghi 1 . 1 Hospital Luigi Sacco, Milano, Italy;<br />
2<br />
COB,Centro Oculistico Bergamasco, Bergamo,<br />
Italy *CR<br />
4816 — D0255 In vivo imaging of lamina<br />
cribrosa pore and optic nerve head geometry<br />
in normal human eyes. Amitabha S. Bhakta, D.<br />
J. Marrelli, N. Sredar, K. M. Ivers, N. B. Patel,<br />
H. M. Queener, J. Porter. College of Optometry,<br />
University of Houston, Houston, TX *CR<br />
4817 — D0256 Frequency of Abnormal Retinal<br />
Nerve Fiber Layer and Ganglion Cell Layer<br />
SDOCT Scans in Healthy Eyes and Glaucoma<br />
Suspects in a Prospective Longitudinal Study.<br />
Shawn M. Iverson 1 , M. Sehi 1 , W. J. Feuer 2 , W.<br />
Shi 2 , D. S. Greenfield 1 . 1 Glaucoma, University of<br />
Miami, Palm Beach Gardens, FL; 2 Ophthalmology,<br />
University of Miami, Miami, FL *CR, f<br />
4818 — D0257 Inner Nuclear Layer (INL)<br />
Cystoid Spaces (Lacunae) Observed in<br />
Experimental Glaucoma and Axotomy in Non-<br />
Human Primates (NHPs). T Michael Nork 1, 2 ,<br />
C. A. Rasmussen 1, 2 , J. N. Ver Hoeve 1, 2 , C. J.<br />
Murphy 3, 2 , M. W. Neider 1, 2 , C. B. Kim 1, 2 , B. J.<br />
Christian 4 . 1 Ophthal & Visual Sciences, Univ<br />
of Wisconsin-Madison, Madison, WI; 2 Ocular<br />
Services On Demand (OSOD), LLC, Madison, WI;<br />
3<br />
Surgical Radiol Sci-Sch of Veterinary Medicine,<br />
Univ California--Davis, Davis, CA; 4 Covance, Inc,<br />
Madison, WI *CR<br />
4819 — D0258 Computational discovery of<br />
optic nerve head phenotypes. Mark Christopher 1 ,<br />
L. Tang 2 , J. H. Fingert 2 , T. E. Scheetz 2, 1 , M. D.<br />
Abramoff 2, 3 . 1 Biomedical Engineering, University<br />
of Iowa, Iowa City, IA; 2 Ophthalmology and<br />
Visual Sciences, University of Iowa, Iowa City, IA;<br />
3<br />
Veterans Affairs, University of Iowa, Iowa City,<br />
IA *CR<br />
4820 — D0259 The Effect of Image Quality<br />
on the Reliability of Nerve Fiber Layer<br />
Measurements with Fourier-Domain OCT. Ou<br />
Tan 1 , X. Zhang 1 , N. A. Loewen 2 , J. S. Schuman 2 ,<br />
D. S. Greenfield 3 , R. Varma 4 , D. Huang 1 .<br />
1<br />
Ophthalmology, Oregon Health & Science Univ,<br />
Portland, OR; 2 Opthalmology, University of<br />
Pittsburgh School of Medicine, Pittsburgh, PA;<br />
3<br />
Ophthalmology, Bascom Palmer Eye Institute,<br />
Miami, FL; 4 Ophthalmology, University of Southern<br />
California and Doheny Eye Institute, Los Angeles,<br />
CA *CR, f<br />
4821 — D0260 Combining Optical Coherence<br />
Topography measurements using the ‘Random<br />
Forest’ decision tree classifier improves the<br />
diagnosis of glaucoma. Koichiro Sugimoto, H.<br />
Murata, H. Hirasawa, C. Mayama, M. Aihara, R.<br />
Asaoka. Department of Ophthalmology, University<br />
of Tokyo Graduate School of Medicine, Tokyo,<br />
Japan *CR<br />
4822 — D0261 Comparison of Gonioscopy<br />
with Cirrus and Visante Optical Coherence<br />
Tomography (OCT) for Anterior Chamber Angle<br />
Assessment in Glaucoma Patients. Cindy X. Hu,<br />
C. Zangalli, A. Mantravadi, M. Ali, B. M. Faria,<br />
J. Richman, S. S. Wizov, R. Razeghinejad, M. R.<br />
Moster, L. Katz. Glaucoma Research, Wills Eye<br />
Institute, Philadelphia, PA *CR<br />
4823 — D0262 In Vivo Structure of the<br />
Schlemm’s Canal and the Collector Channels<br />
in Eyes with Chronic Angle-Closure Glaucoma<br />
Compared to Normal Eyes. Camila F. Netto 1 ,<br />
S. Park 1, 2 , W. A. Kirkland 1 , R. L. Furlanetto 1 , Y.<br />
Liu 1, 3 , J. M. Liebmann 1, 4 , R. Ritch 1, 2 . 1 Moise and<br />
Chella Safra Advanced Ocular Imaging Laboratory,<br />
Einhorn Clinical Research Center, New York Eye<br />
and Ear Infirmary, New York, NY; 2 Department<br />
of Ophthalmology, New York Medical College,<br />
Valhalla, NY; 3 New York Medical College, Valhalla,<br />
NY; 4 Department of Ophthalmology, New York<br />
University School of Medicine, New York, NY *CR<br />
4824 — D0263 Stereo digital photography<br />
demonstrates excellent reproducibility<br />
with stereo slide film for the evaluation of<br />
glaucomatous optic disc features. Faazil Kassam 2 ,<br />
S. Arora 1 , C. J. Rudnisky 1 , G. Douglas 2 , M. C.<br />
Edwards 1 , K. Verstraten 2 , B. K. Wong 3 , K. F. Damji 1 .<br />
1<br />
Ophthalmology, University of Alberta, Edmonton,<br />
AB, Canada; 2 Ophthalmology, University of<br />
Calgary, Calgary, AB, Canada; 3 Ophthalmology,<br />
Loma Linda University, Loma Linda, CA *CR<br />
4825 — D0264 Comparison of Cirrus spectraldomain<br />
optical coherence tomography (OCT)<br />
-measured macula ganglion cell-inner plexiform<br />
layer (GCIPL) thickness and circumpapillary<br />
retinal nerve fiber layer (cpRNFL) thicknessdeviation<br />
maps for detection of localized retinal<br />
nerve fiber layer (RNFL) defects in glaucoma. Yu<br />
Jeong Kim 1 , M. Kim 1, 2 , K. Park 1, 2 , J. Jeoung 1, 2 , Y.<br />
Choi 2 , K. Kim 2 , D. Kim 1, 2 . 1 Ophthalmology, Seoul<br />
National University College of Medicine, Seoul,<br />
Republic of Korea; 2 Ophthalmology, Seoul National<br />
University Hospital, Seoul, Republic of Korea<br />
4826 — D0265 Does reduction in retinal nerve<br />
fiber layer (RNFL) birefringence precede change<br />
in RNFL thickness in glaucoma? Guihua Xu, Y.<br />
Tse, C. K. Leung. The Chinese University of Hong<br />
Kong, Hong Kong, China *CR<br />
4827 — D0266 Glaucoma Clinician (GC)<br />
Color Stereophoto (CSphoto) Rim Estimation<br />
Compared to Colocalized Spectral Domain<br />
Optical Coherence Tomography (SDOCT)<br />
Minimum Rim Measurements. Robert M. Kinast,<br />
R. Ren, H. Koenigsman, H. Yang, S. K. Gardiner, J.<br />
Reynaud, S. L. Mansberger, B. Fortune, S. Demirel,<br />
C. F. Burgoyne. Discoveries in Sight Research<br />
Laboratories, Devers Eye Institute, Legacy<br />
Research Institute, Portland, OR *CR<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
309
4828 – 4849 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
4828 — D0267 Ability of spectral domain<br />
optical coherence tomography to diagnose<br />
preperimetric glaucoma. Chandrasekhar<br />
Garudadri, H. L. Rao, U. Addepalli, S. Chaudhary,<br />
T. Kumbar, S. Senthil. Glaucoma, L V Prasad Eye<br />
Institute, Hyderabad, India *CR<br />
4829 — D0268 A novel alignment and<br />
subtraction technique for the detection of<br />
glaucoma progression. Elizabeth D. Marlow 1, 2 ,<br />
M. M. McGlynn 2 , N. M. Radcliffe 2 . 1 New York<br />
University School of Medicine, New York, NY;<br />
2<br />
Ophthalmology, Weill Cornell Medical College,<br />
New York, NY *CR<br />
4830 — D0269 Glaucoma discrimination of<br />
ganglion cell complex measurements with two<br />
SD-OCT. Marlene Francoz, H. El Chehab, J.<br />
Fenolland, M. Delbarre, J. Giraud, F. May, J. G.<br />
Renard. Military Hosp of Val-de-Grace, Paris, Paris,<br />
France<br />
4831 — D0270 Enhanced Depth Imaging<br />
Optical Coherence Tomography of Trabecular<br />
Outflow Pathway. Anum Butt 1 , S. Park 2, 3 , R.<br />
L. Furlanetto 2 , W. A. Kirkland 2 , C. F. Netto 2 ,<br />
M. Al-Jumayli 2 , J. M. Liebmann 2, 4 , R. Ritch 2, 3 .<br />
1<br />
Department of Ophthalmology, The Aga Khan<br />
University, Karachi, Pakistan; 2 Moise and Chella<br />
Safra Advanced Ocular Imaging Laboratory,<br />
Einhorn Clinical Research Center, New York Eye<br />
and Ear Infirmary, New York, NY; 3 Department<br />
of Ophthalmology, New York Medical College,<br />
Valhalla, NY; 4 Department of Ophthalmology, New<br />
York University School of Medicine, New York,<br />
NY *CR<br />
4832 — D0271 Automated Flicker<br />
Chronoscopy for the Identification of<br />
Preperimetric Glaucomatous Progression.<br />
Nathan M. Radcliffe, J. R. Ehrlich, F. Q. Silva,<br />
Z. Syed. Ophthalmology, Weill Cornell Medical<br />
College, New York, NY *CR<br />
4833 — D0272 Developments in Optical<br />
Coherence Tomography Imaging in a Rat<br />
Model of Glaucoma. Jean-Remi Fenolland 1, 2 ,<br />
C. Boucher 2 , M. A. Mayer 3 , W. H. Rostene 2 , C.<br />
Baudouin 2, 4 , A. Denoyer 2, 4 . 1 Ophthalmology, Val<br />
de Grace Military Hospital, Paris, France; 2 Team<br />
S12, Vision Institute, UPMC University Paris 6;<br />
UMRS968 INSERM; UMR7210 CNRS, Paris,<br />
France; 3 Pattern Recognition Lab, University<br />
of Erlangen-Nuremberg, Nuremberg, Germany;<br />
4<br />
Quinze-Vingts National Ophthalmology Hospital,<br />
Paris, France<br />
4834 — D0273 Optic disc and neuroretinal rim<br />
area measurements with spectral-domain optical<br />
coherence tomography and confocal scanning<br />
laser ophthalmoscopy in myopic eyes. Kunliang<br />
Qiu. JSIEC, Shantou, Afghanistan<br />
4835 — D0274 Association of vascular risk<br />
factors with structural glaucomatous progression<br />
by flicker chronoscopy. Margaret M. McGlynn,<br />
J. R. Ehrlich, E. D. Marlow, F. Q. Silva, N. M.<br />
Radcliffe. Weill Cornell Medical College, New<br />
York, NY *CR<br />
4836 — D0275 Optic nerve head analysis using<br />
confocal scanning laser ophthalmoscopy and<br />
spectral-domain optical coherence tomography.<br />
Gloria Roberti 1 , F. Oddone 1 , L. Tanga 1 , M.<br />
Michelessi 2 , D. De Geronimo 1 , M. Centofanti 1, 2 , G.<br />
Manni 1, 2 . 1 IRCCS Fondazione GB Bietti, Rome,<br />
Italy; 2 DSCMT, University of Rome Tor Vergata,<br />
Rome, Italy *CR<br />
4837 — D0276 A Tree Classification Method<br />
for Identifying Normal Eyes, Non-Progressing<br />
Glaucoma Eyes, and Progressing Glaucoma Eyes<br />
from Spectral Domain OCT RNFL Thickness<br />
Measurements. Michael H. Goldbaum, S. Yousefi,<br />
A. Belghith, L. M. Zangwill, F. A. Medeiros, R. N.<br />
Weinreb, D. Meira-Freitas, N. Hatami, C. Bowd.<br />
Ophthalmology, University of California at San<br />
Diego, La Jolla, CA *CR, f<br />
4838 — D0277 Utilization of Novel Technology<br />
to Improve Accuracy and Efficiency of Assessing<br />
Progression of Glaucomautous Changes in<br />
Serial Fundus Photos. Ozgur Ozkan 1 , R. Barnes 2 ,<br />
B. Markowitz 1 . 1 Ophthalmology, University of<br />
South Carolina/Palmetto Health, Columbia,<br />
SC; 2 Ophthalmology, Georgetown University/<br />
Washington Hospital Center, Washington, DC *CR<br />
4839 — D0278 Objective Assessment of<br />
Glaucoma Suspect Comparing Different Imaging<br />
Techniques. Eduardo M. Normando 1, 2 , L. A.<br />
Turner 1 , F. Ahmed 2 , P. A. Bloom 2 , M. Cordeiro 1, 2 .<br />
1<br />
Glaucoma & Retinal Neurodegeneration Research<br />
Group, Visual Neuroscience, UCL Institute of<br />
Ophthalmology, London, United Kingdom;<br />
2<br />
Western Eye Hospital, Imperial College Healthcare<br />
Trust, London, United Kingdom *CR<br />
4840 — D0279 Evaluation of Inner to Outer<br />
Retina Area Ratio for Detection of Glaucoma<br />
with Macular OCT Imaging. Navid Amini 1, 4 , N.<br />
Cirineo 1 , S. Knipping 1 , H. Hosseini 1 , J. A. Giaconi 1 ,<br />
S. K. Law 1 , T. Chou 3 , L. A. Vese 2 , J. Caprioli 1 ,<br />
K. Nouri-Mahdavi 1 . 1 Ophthalmology, Jules<br />
Stein Eye Institute at UCLA, Los Angeles, CA;<br />
2<br />
Department of Mathematics, UCLA, Los Angeles,<br />
CA; 3 Department of Biomathematics, UCLA, Los<br />
Angeles, CA; 4 UCLA Wireless Health Institute, Los<br />
Angeles, CA *CR<br />
4841 — D0280 The Magnitude and Direction of<br />
Mismatch between Bruch’s Membrane Opening<br />
(BMO) and Anterior Scleral Canal Opening<br />
(ASCO) within Spectral Domain Optical<br />
Coherence Tomography (SD-OCT) Optic Nerve<br />
Head (ONH) Scans of Ocular Hypertension and<br />
Glaucoma Patients. Christy A. Hardin, H. Yang, R.<br />
Ren, L. He, S. K. Gardiner, B. Fortune, S. Demirel,<br />
C. F. Burgoyne. Discoveries in Sight Research<br />
Laboratory, Devers Eye Institution and Legacy<br />
Research Institute, Porltand, OR *CR<br />
4842 — D0281 Variability of the Foveal-<br />
Bruch’s Membrane Opening centroid (FoBMO)<br />
axis angle in patients with ocular hypertension<br />
and early glaucoma. Luke Reyes, R. Ren, J.<br />
Reynaud, H. Yang, S. K. Gardiner, B. Fortune,<br />
S. Demirel, C. F. Burgoyne. Discoveries in Sight<br />
Research Laboratories, Devers Eye Institute,<br />
Legacy Research Institute, Portland, OR *CR<br />
4843 — D0282 Quadratic Bayesian Pattern<br />
Detection for Detecting Glaucomatous Change<br />
in Follow-up SD-OCT RNFL Thickness<br />
Measurements. Siamak Yousefi, A. Belghith, M.<br />
H. Goldbaum, L. M. Zangwill, F. A. Medeiros, R.<br />
N. Weinreb, R. Lisboa, C. Bowd. Ophthalmology,<br />
Hamilton Glaucoma Center, La Jolla, CA *CR, f<br />
4844 — D0283 A method for mapping retinal<br />
nerve fiber layer birefringence. Juan Reynaud,<br />
B. Fortune. Discoveries in Sight Research<br />
Laboratories, Devers Eye Institute and Legacy<br />
Research Institute, Portland, OR *CR<br />
4845 — D0284 The Prevalence of Cirrus SD-<br />
OCT Ganglion Cell Segmentation Errors in<br />
High Myopes. Tessa Johung 1 , J. D. Oakley 2 , D.<br />
Russakoff 2 , S. Sabhlok 1 , F. Li 3 , R. Chang 1 . 1 Stanford<br />
University, Stanford, CA; 2 Voxeleron, Pleasanton,<br />
CA; 3 Dept. of Ophthalmology and Visual Sciences,<br />
Chinese University of Hong Kong, Hong Kong,<br />
China *CR<br />
4846 — D0285 Optic disc morphology<br />
parameters in primary open angle glaucoma in<br />
Japanese using a stereo fundus camera - The<br />
Glaucoma Stereo Analysis Study (GSAS). Yu<br />
Yokoyama 1 , M. Tanito 2 , K. Nitta 3 , M. Katai 4 , Y.<br />
Kitaoka 5 , K. Omodaka 1 , S. Tsuda 1 , T. Nakagawa 6 ,<br />
T. Nakazawa 1 . 1 Department of Ophthalmology,<br />
Tohoku university, Sendai-shi, Japan; 2 Department<br />
of Ophthalmology, Shimane University Faculty<br />
of Medicine, Izumo-shi, Japan; 3 Department of<br />
Ophthalmology, Fukui-ken Saiseikai Hospital,<br />
Fukui-shi, Japan; 4 Department of Ophthalmology,<br />
Sapporo Teishin Hospital, Sapporo-shi, Japan;<br />
5<br />
Department of Ophthalmology, St. Marianna<br />
University School of Medicine, Sapporo-shi, Japan;<br />
6<br />
Research & Development Section, Electronics &<br />
Optics Division, Kowa Company, Ltd, Nagoya-shi,<br />
Japan *CR<br />
4847 — D0286 Glaucoma Assessment using<br />
Retinal Topography by Scanning Laser<br />
Ophthalmoscope Imaging. Maarten Huijbregtse,<br />
D. De Brouwere, M. Mensink. i-Optics BV, The<br />
Hague, Netherlands *CR<br />
4848 — D0287 Macular Retinal Ganglion<br />
Cell Complex Thickness and Its Relationship<br />
to the Retinal Nerve Fiber Layer in Non-<br />
Human Primates with Ocular Hypertension.<br />
Kaveh Azartash, J. A. Burke. Biological Sciences,<br />
Allergan, Irvine, CA *CR<br />
4849 — D0288 Longitudinal Measurements<br />
In Vivo of Retinal Nerve Fiber Layer Thickness<br />
(RNFLT) and Retinal Ganglion Cell (RGC)<br />
Density after Optic Nerve Transection (ONT)<br />
in Rat. Tiffany E. Choe, C. J. Abbott, K. Young,<br />
B. Fortune. Discoveries in Sight, Devers Eye Inst,<br />
Legacy Health, Portland, OR *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
310
<strong>Wednesday</strong> – Posters – 4850 – 4871<br />
4850 — D0289 In Vivo Dimensions of<br />
Schlemm’s Canal and Number of Collector<br />
Channels in the Nasal and Temporal Areas of<br />
Normal Eyes. Wendy A. Kirkland 1 , S. Park 1, 2 ,<br />
R. L. Furlanetto 1 , C. F. Netto 1 , Y. Liu 1, 3 , J. M.<br />
Liebmann 1, 4 , R. Ritch 1, 2 . 1 Moise and Chella Safra<br />
Advanced Ocular Imaging Laboratory, Einhorn<br />
Clinical Research Center, New York Eye and<br />
Ear Infirmary, New York, NY; 2 Department<br />
of Ophthalmology, Valhalla, NY; 3 New York<br />
Medical College, Valhalla, NY; 4 Department of<br />
Ophthalmology, New York University School of<br />
Medicine, New York, NY *CR<br />
4851 — D0290 The macular retinal layer<br />
thickness in glaucoma patients. Yoshiaki Kiuchi,<br />
U. Rimayanti, M. Latief. Ophthalmology & Visual<br />
Science, Hiroshima University, Hiroshima, Japan<br />
4852 — D0291 A comparison of retinal<br />
nerve fiber layer quadrant thickness between<br />
glaucomatous and glaucoma suspect eyes. Alicia<br />
M. Eby, R. Momi, J. Tannir, B. A. Hughes, A. Goyal,<br />
A. Shukairy, C. Kim, M. H. Peracha, F. Fatima,<br />
M. McQueen. Kresge Eye Institute, Wayne State<br />
University School of Medicine, Detroit, MI<br />
Exhibit Hall D0292-D0309<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Multidisciplinary Ophthalmic Imaging<br />
444 Choroid and Sclera Imaging<br />
Moderator: Eric H. Souied<br />
4853 — D0292 Effect of Acoustic Radiation<br />
Force on the Retina, Choroid and Orbital<br />
Tissues. Ronald H. Silverman 1, 2 , R. Urs 1 , H. Lloyd 1 .<br />
1<br />
Ophthalmology, Columbia University Medical<br />
Center, New York, NY; 2 FL Lizzi Center for<br />
Biomedical Engineering, Riverside Research, New<br />
York, NY<br />
4854 — D0293 Analysis of the Vascular Layers<br />
and Morphology of the Choroid in Eyes with<br />
Diabetic Retinopathy using Spectral-Domain<br />
Optical Coherence Tomography. Erika Brewer 1, 2 ,<br />
M. Adhi 1, 2 , N. K. Waheed 1, 2 , J. S. Duker 1, 2 . 1 New<br />
England Eye Center, Boston, MA; 2 Tufts University<br />
School of Medicine, Boston, MA *CR<br />
4855 — D0294 Pilot Study of the Topographic<br />
Correlation Between Reticular Pseudo-drusen<br />
and the Choroidal Vasculature Using En Face<br />
Optical Coherence Tomography. Jonathan Chou,<br />
S. D. Rollins, D. S. Grewal, S. Khan, A. A. Fawzi.<br />
Ophthalmology, Northwestern University, Chicago,<br />
IL<br />
4856 — D0295 Choroidal Thickness in Adult<br />
Onset Foveomacular Vittelliform Dystrophy and<br />
in Exudative Age-related Macular Degeneration.<br />
Florence Coscas, N. Puche, G. J. Coscas, C.<br />
Francais, M. Srour, G. Mimoun, G. Querques, E.<br />
H. Souied. Ophthalmology, University, Paris Est,<br />
Creteil, France *CR<br />
4857 — D0296 Differences in subfoveal<br />
choroidal thickness between acute and chronic<br />
central serous chorioretinopathy measured with<br />
enhanced depth imaging OCT. Nikolaus Feucht,<br />
C. Lohmann, P. Kook, C. Mayer, M. Zenk, K. M.<br />
Wand, M. M. Maier. Ophthalmology, Klinikum<br />
rechts der Isar, Technische Universität München,<br />
Munich, Germany *CR<br />
4858 — D0297 Enface Features of Chronic<br />
Central Serous Chorioretinopathy on Swept-<br />
Source Optical Coherence Tomography. Daniela<br />
Ferrara 1, 3 , K. J. Mohler 2 , M. Adhi 1 , J. J. Liu 2 , I.<br />
Grulkowski 2 , M. F. Kraus 2, 4 , N. K. Waheed 1 , C.<br />
R. Baumal 1 , J. G. Fujimoto 2 , J. S. Duker 1 . 1 New<br />
England Eye Center, Tufts University, Boston,<br />
MA; 2 Department of Electrical Engineering and<br />
Computer Science and Research Laboratory of<br />
Electronics, Massachusetts Institute of Technology,<br />
Cambridge, MA; 3 Digital Angiography Reading<br />
Center, New York, NY; 4 Pattern Recognition<br />
Lab and Graduate School in Advanced Optical<br />
Technologies (SAOT), 4 University Erlangen-<br />
Nuremburg, Erlangen, Germany *CR<br />
4859 — D0298 Evaluation of choroidal<br />
thickness in retinal vein occlusions using<br />
enhanced depth imaging optical coherence<br />
tomography. Amar P. Patel, S. S. Park.<br />
Ophthalmology, University of California, Davis,<br />
Sacramento, CA<br />
4860 — D0299 Diffuse choroidal thickening in<br />
patients with Vogt-Koyanagi-Harada Syndrome.<br />
Maria de las Mercedes Frick, M. Zunino, B. A.<br />
Schlaen, M. Lopez, E. Hurtado Jallaza, C. A.<br />
Couto. Ophthalmology, University of Buenos Aires,<br />
Buenos Aires, Argentina<br />
4861 — D0300 Punctate Inner Choroidopathy<br />
characterization by Enhanced Depth Imaging-<br />
Optical Coherence Tomography: Qualitative<br />
analysis of PIC lesions & relationship with<br />
clinical features. Raquel Garcia-Cabrera, J.<br />
Zarranz-Ventura, D. A. Sim, P. A. Keane, C. A.<br />
Egan, P. J. Patel, M. Westcott, R. W. Lee, A. Tufail,<br />
C. E. Pavesio. Moorfields Eye Hospital, London,<br />
United Kingdom *CR<br />
4862 — D0301 The effect of scleral buckling<br />
surgery on choroidal thickness measured<br />
by enhanced depth optical coherence<br />
tomography. Alla Kelly, D. D. Koozekanani,<br />
J. Terry, S. R. Montezuma. Ophthalmology and<br />
Visual Neurosciences, University of Minnesota,<br />
Minneapolis, MN<br />
4863 — D0302 Quantitative measurement of<br />
laser-induced choroidal neovascularization with<br />
spectral-domain optical coherent tomography.<br />
Wenqiu Wang. Shanghai Key Lab of Ocular Fundus,<br />
Shanghai First People’s Hospital, Shanghai, China<br />
4864 — D0303 Peripapillary Choroidal<br />
Thickness Analysis with Optical Coherence<br />
Tomography in Unilateral Pseudoexfoliation<br />
Glaucoma and Pseudoexfoliation Syndrome.<br />
Claudia E. Bartolini, J. Zhang, M. Adhi, J. S. Duker,<br />
C. Krishnan. Ophthalmology, New England Eye<br />
Center/Tufts, Boston, MA *CR<br />
4865 — D0304 Enhanced Depth Imaging<br />
Optical Coherence Tomography of Choroidal<br />
Metastasis in 31 Eyes. SAAD AL-DAHMASH 1, 2 ,<br />
C. L. Shields 2 , S. Kaliki 2 , T. V. Johnson 2 , J.<br />
Shields 2 . 1 King Saud University, Riyadh, Saudi<br />
Arabia; 2 Oncology Service, Wills Eye Institute,<br />
Philadelphia, PA<br />
4866 — D0305 The comparison between<br />
subfoveal choroidal thickness measured with two<br />
different SD-OCT. Yuki Maekawa, K. Suzuma, E.<br />
Tsuiki, T. Kitaoka. Department of Ophthalmology<br />
& Visual Sciences, Nagasaki University Graduate<br />
School of Biomedical Sciences, Nagasaki, Japan<br />
4867 — D0306 Comparison of the Accuracy of<br />
Choroidal Thickness Measurements Using SD-<br />
OCT With and Without EDI and Swept Source<br />
OCT and Volumetric Analysis of the Choroid<br />
in Healthy Eyes. Mehreen Adhi 1, 2 , J. J. Liu 3 , A.<br />
H. Qavi 1 , I. Grulkowski 3 , K. J. Mohler 3 , C. D. Lu 3 ,<br />
M. F. Kraus 3 , N. K. Waheed 1, 2 , J. G. Fujimoto 3 ,<br />
J. S. Duker 1, 2 . 1 Ophthalmology, New England<br />
Eye Center, Tufts Medical Center, Boston, MA;<br />
2<br />
Ophthalmology, Tufts Univ School of Medicine,<br />
Boston, MA; 3 Research Laboratory of Electronics,<br />
Massachusetts Institute of Technology, Cambridge,<br />
MA *CR<br />
4868 — D0307 Optovue OCT as an Imaging<br />
Modality for Scleral Thickness. Stephanie K.<br />
Cramer, R. M. Beardsley, C. J. Flaxel, E. B. Suhler,<br />
N. S. Schubach. Ophthalmology, Casey Eye<br />
Institute, Portland, OR *CR<br />
4869 — D0308 Choroidal thickness in<br />
emmetropic and myopic children and adults, and<br />
myopic anisometropes. Andrew K. Lam, Y. Wong,<br />
B. S. Yu. School of Optometry, The Hong Kong<br />
Polytechnic University, Hong Kong, Hong Kong<br />
4870 — D0309 Choroidal Volume in Healthy<br />
Pediatric Population. Chiara Mapelli 1, 2 ,<br />
E. Tabacchi 2 , S. Osnaghi 2 , L. Dell’Arti 1, 2 , G.<br />
Barteselli 1 , M. Clerici 1 , F. Viola 1, 2 , R. Ratiglia 1, 2 .<br />
1<br />
University of Milan, Milan, Italy; 2 Eye Clinic,<br />
Fondazione IRCCS Ca’ Granda Ospedale<br />
Policlinico, Milan, Italy<br />
Exhibit Hall D0310-D0336<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Multidisciplinary Ophthalmic Imaging<br />
445 Imaging of Animal Models<br />
Moderator: Mahnaz Shahidi<br />
4871 — D0310 Quantitative Fundus<br />
Autofluorescence in Mice. Correlation with<br />
HPLC Quantitation of RPE Lipofuscin and<br />
Measurement of Retina Outer Nuclear Layer<br />
Thickness. Janet R. Sparrow 1, 2 , A. M. Blonska 1 ,<br />
E. Flynn 1 , T. Duncker 1 , J. P. Greenberg 1 , R.<br />
Secondi 1 , K. Ueda 1 , F. C. Delori 3 . 1 Department<br />
of Ophthalmology, Columbia University, New<br />
York, NY; 2 Pathology and Cell Biology, Columbia<br />
University, New York, NY; 3 Schepens Eye Research<br />
Institute, Harvard Medical School, Boston, MA<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
311
4872 – 4892 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
4872 — D0311 In Vivo Imaging of hESC-RPE<br />
Implanted in the RCS Rat Using InfraRed<br />
Reflectance. Aldo A. Oregon-Miranda 1, 2 , R.<br />
Ribeiro 1 , W. Charafeddin 1 , B. Diniz 1 , M. J. Koss 1 ,<br />
P. B. Thomas 1 , B. B. Thomas 1 , G. J. Chader 1 ,<br />
D. R. Hinton 1 , M. S. Humayun 1 . 1 Doheny eye<br />
institute, University of Southern California, Los<br />
Angeles, CA; 2 Oftalmologia, Antiguo Hospital<br />
Civil de Guadalajara, Fray Antonio Alcalde, UDG,<br />
Guadalajara, Mexico *CR<br />
4873 — D0312 Spectral Domain Optical<br />
Coherence Tomography as a Measure of Axonal<br />
Degeneration and Protection in Experimental<br />
Autoimmune Encephalomyelitis. Anastasiya<br />
Johnson 1 , K. V. Michaels 1 , B. K. Morris 2 , A. K.<br />
Garg 1 , P. Chaudhary 2 , H. E. Titus 1 , M. D. Andrews 1 ,<br />
D. Bourdette 2 , M. E. Pennesi 1 , G. H. Marracci 2 .<br />
1<br />
Ophthalmology, Oregon Health & Science<br />
Institute, Portland, OR; 2 Neurology, Oregon Health<br />
& Science University, Portland, OR *CR<br />
4874 — D0313 Comparison of ocular<br />
parameters of Bugeye and Wild-type zebrafish<br />
using Optical Coherence Tomography. Pinakin G.<br />
Davey, D. Cameron. College of Optometry, Western<br />
University of Health Sciences, Pomona, CA<br />
4875 — D0314 Multimodal adaptive optics<br />
imaging system (MAOS) for small animals. Ankit<br />
Patel 1 , R. D. Ferguson 1 , M. Mujat 1 , N. Iftimia 1 , J.<br />
D. Akula 2 . 1 Biomedical Imaging Group, Physical<br />
Sciences Inc, Andover, MA; 2 Ophthalmology,<br />
Children’s Hospital Boston, Boston, MA *CR<br />
4876 — D0315 Assessment of Vascular<br />
Integrity and Leukocyte Endothelial Interaction<br />
in the Murine Retina After Ionizing Radiation<br />
by in vivo retinal imaging. Clemens Alt, J. M.<br />
Runnels, G. Teo, C. P. Lin. Wellman Center for<br />
Photomedicine, Massachusetts General Hospital,<br />
Boston, MA<br />
4877 — D0316 Fluorescence lifetime imaging in<br />
mouse models. Chantal Dysli, V. Enzmann, S. Wolf,<br />
M. S. Zinkernagel. University of Bern, Department<br />
of Ophthalmology, Bern, Switzerland *CR<br />
4878 — D0317 Density and distribution of<br />
NG2+ pericytes in the living mouse retina.<br />
HoanVu Nguyen 1 , D. R. Williams 2, 3 , J. B. Schallek 2 .<br />
1<br />
Department of Biological Sciences, University of<br />
Denver, Denver, CO; 2 Center for Visual Science,<br />
University of Rochester, Rochester, NY; 3 The<br />
Institute of Optics, University of Rochester,<br />
Rochester, NY *CR<br />
4879 — D0318 A Novel Rodent Model of<br />
Retinal Edema. Xin Xia 1, 2 , M. Zheng 1 , R. Wen 3 , W.<br />
Chen 1 , Q. Gu 1, 2 . 1 Shanghai First People’s Hospital,<br />
Shanghai Jiao Tong University, Shanghai, China;<br />
2<br />
Shanghai Key Laboratory for Ocular Fundus<br />
Diseases, Shanghai, China; 3 Bascom Palmer Eye<br />
Institute, University of Miami, Miami, FL *CR<br />
4880 — D0319 Single- and multi-photon<br />
fluorescence retinal imaging in the intact rodent<br />
eye: a comparison. Adi Schejter, N. Farah, L. Tsur,<br />
S. Shoham. Biomedical Engineering, Technion,<br />
Haifa, Israel<br />
4881 — D0320 Retinal intrinsic optical signals<br />
in rabbits. Azadeh Naderian 1, 2 , L. Bussieres 1 , S.<br />
Thomas 1 , F. Lesage 2 , C. Casanova 1 . 1 University<br />
of Montreal, montreal, QC, Canada; 2 Ecole<br />
Polytechnique, montreal, QC, Canada *CR<br />
4882 — D0321 Contrast-enhanced MRI<br />
of Brain Abnormalities and Cerebrospinal<br />
Fluid (CSF) Buildup in CEP290 Knockout<br />
(ko) Mice: Effect of Ciliogenesis on Volumetry<br />
of CSF, Cerebrum and Cerebellum. Mrinal<br />
K. Dewanjee, R. A. Rachel, E. Yamamoto, J. P.<br />
Munasinghe, L. Dong, A. Swaroop. Neurobiology-<br />
Neurodegeneration & Repair, National Eye<br />
Institute, Bethesda, MD<br />
4883 — D0322 Retinal thickness changes<br />
in mice with streptozotocin-induced diabetes<br />
mellitus quantified using an enhanced Iowa<br />
Reference Algorithm. Woo Jin Jeong 1, 2 , M. D.<br />
Abramoff 1, 3 , B. J. Antony 4 , C. Jiao 1 , M. K. Garvin 3, 5 ,<br />
E. H. Sohn 1 . 1 Institute for Vision Research,<br />
Ophthalmology and Visual Sciences, University<br />
of Iowa, Iowa city, IA; 2 Ophthalmology, Dong-A<br />
University College of Medicine and Medical<br />
Science Research Center, busan, Republic of Korea;<br />
3<br />
Iowa Institute for Biomedical Imaging, University<br />
of Iowa, Iowa city, IA; 4 Department of Electrical<br />
and Computer Engineering, Iowa city, IA; 5 VA<br />
Medical Center, Iowa city, IA *CR<br />
4884 — D0323 Application of phase variance<br />
optical coherence tomography for in-vivo<br />
imaging of retinal micro-vasculature in mice.<br />
Robert J. Zawadzki 1, 2 , Y. Jian 3 , M. V. Sarunic 3 , J. S.<br />
Werner 2, 4 , E. N. Pugh 1, 5 . 1 Cell Biology and Human<br />
Anatomy, Univerisy of California Davis, Davis,<br />
CA; 2 Ophthalmology & Vision Science, University<br />
of California Davis, Sacramento, CA; 3 Engineering<br />
Science, Simon Fraser University, Burnaby, BC,<br />
Canada; 4 Neurobiology, Physiology, and Behavior,<br />
Univeristy of California Davis, Davis, CA;<br />
5<br />
Physiology and Membrane Biology, Univeristy of<br />
California Davis, Davis, CA<br />
4885 — D0324 Correcting Lateral<br />
Magnification in OCT Imaging of the Rat Eye.<br />
Diana C. Lozano, M. D. Twa. College of Optometry,<br />
University of Houston, Houston, TX<br />
4886 — D0325 Inner Retinal Oxygen<br />
Metabolism and Delivery in Streptozotocin<br />
Diabetic Rats. Justin Wanek, P. Teng, N. P. Blair,<br />
M. Shahidi. Ophthalmology and Visual Sciences,<br />
University of Illinois at Chicago, Chicago, IL *CR<br />
4887 — D0326 In vivo imaging of a new<br />
indocyanine green micelle formulation in an<br />
animal model. Steffen Schmitz-Valckenberg 1 , J.<br />
Meyer 1 , A. R. Cunea 1 , P. Welker 2 , K. Licha 2 , D.<br />
Sonntag-Bensch 1 , F. G. Holz 1 . 1 Ophthalmology,<br />
University of Bonn, Bonn, Germany; 2 mivenion<br />
GmbH, Berlin, Germany *CR<br />
4888 — D0327 Retinal OCT Reflectivity<br />
Profiles In Three Laboratory Animal Species.<br />
Marina Garcia Garrido 1 , C. Seide 1 , V. Sothilingam 1 ,<br />
S. Julien 2 , U. Schraermeyer 2 , N. Tanimoto 1 , M. W.<br />
Seeliger 1 . 1 Division of Ocular Neurodegeneration,<br />
Ctr Ophthal Inst Ophthalmic Resrch, Tuebingen,<br />
Germany; 2 Section of Experimental Vitreoretinal<br />
Surgery, Ctr Ophthal Inst Ophthalmic Resrch,<br />
Tuebingen, Germany *CR<br />
4889 — D0328 Functional imaging of retina<br />
in response to defocused grating light stimuli in<br />
cats. Yoko Hirohara 1, 2 , T. Mihashi 3, 2 , H. Kanda 2 ,<br />
T. Miyoshi 4 , T. Morimoto 5 , J. S. Wolffsohn 6 , T.<br />
Fujikado 2 . 1 Optical Engineering Laboratory, Topcon<br />
Corporation, Itabashi-ku, Japan; 2 Department<br />
of Applied Visual Science, Osaka University<br />
Graduate School of Medicine, Suita, Japan;<br />
3<br />
Innovative Research Initiatives, Tokyo Institute<br />
of Technology, Yokohama, Japan; 4 Department of<br />
Integrative Physiology, Osaka University Graduate<br />
School of Medicine, Suita, Japan; 5 Department of<br />
Ophthalmology, Osaka University Graduate School<br />
of Medicine, Suita, Japan; 6 and Health Science,<br />
Aston University, Birmingham, United Kingdom<br />
*CR<br />
4890 — D0329 Peripapillary Rat Sclera<br />
Investigated Using Polarization Sensitive<br />
Optical Coherence Tomography Imaging and<br />
Histological Analysis. Bernhard Baumann 1 ,<br />
S. Rauscher 2 , M. Glösmann 3 , M. Bonesi 1 , E.<br />
Gotzinger 1 , M. Pircher 1 , H. Sattmann 1 , S. Zotter 1 ,<br />
T. Torzicky 1 , C. K. Hitzenberger 1 . 1 Ctr for Med<br />
Physics & Biomed Engineering, Medical University<br />
of Vienna, Vienna, Austria; 2 Core Facility Imaging,<br />
Medical University of Vienna, Vienna, Austria;<br />
3<br />
Core Facility for Research and Technology,<br />
University of Veterinary Medicine Vienna, Vienna,<br />
Austria *CR<br />
4891 — D0330 Pharmacokinetics of I-124<br />
aflibercept after intravitreal injection using<br />
PET/CT imaging after lensectomy in a rabbit<br />
model. John B. Christoforidis 1 , M. M. Williams 2 ,<br />
F. M. Epitropoulos 3 , M. V. Knopp 2 . 1 Department<br />
of Ophthalmology and Vision Science, University<br />
of Arizona College of Medicine, Tucson, AZ;<br />
2<br />
Radiology, The Ohio State University College<br />
of Medicine, Columbus, OH; 3 Ophthalmology,<br />
The Ohio State University College of Medicine,<br />
Columbus, OH<br />
4892 — D0331 Segmentation of Multiple<br />
Intra-retinal Surfaces in Volumetric SD-OCT<br />
Images of Mouse Eyes Using an Improved<br />
Iowa Reference Algorithm. Bhavna J. Antony 1, 3 ,<br />
M. D. Abramoff 2, 3 , W. Jeong 4 , E. H. Sohn 4 , M. K.<br />
Garvin 3, 1 . 1 Department of Electrical and Computer<br />
Engineering, The University of Iowa, Iowa City,<br />
IA; 2 Department of Ophthalmology and Visual<br />
Sciences, The University of Iowa, Iowa City, IA;<br />
3<br />
Center for the Prevention and Treatment of Visual<br />
Loss, VA Health Care System, Iowa City, IA;<br />
4<br />
Institute of Vision Research, Ophthalmology and<br />
Visual Sciences, The University of Iowa, Iowa City,<br />
IA *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
312
<strong>Wednesday</strong> – Posters – 4893 – 4913<br />
4893 — D0332 Spectral-Domain Optical<br />
Coherence Tomography of the Optic Nerve<br />
Head in a Canine Model of Primary Open-Angle<br />
Glaucoma. Annie Oh 1, 2 , C. Harman 1 , K. L. Koehl 1 ,<br />
J. Huang 3 , L. B. Teixeira 4 , L. M. Occelli 1 , E. Storey 5 ,<br />
G. Ying 3 , A. M. Komaromy 1, 6 . 1 College of Veterinary<br />
Medicine, Michigan State University, East Lansing,<br />
MI; 2 College of Veterinary Medicine, Western<br />
University of Health Sciences, Pomona, CA;<br />
3<br />
Scheie Eye Institute, University of Pennsylvania,<br />
Philadelphia, PA; 4 School of Veterinary Medicine,<br />
University of Wisconsin-Madison, Madison, WI;<br />
5<br />
School of Veterinary Medicine, Louisiana State<br />
University, Baton Rouge, LA; 6 School of Veterinary<br />
Medicine, University of Pennsylvania, Philadelphia,<br />
PA<br />
4894 — D0333 Imaging Functional Hyperemia<br />
in Response to Flicker Stimulus in the Rat<br />
Retina Using Ultrahigh-Speed Spectral / Fourier<br />
Domain OCT. WooJhon Choi 1 , A. Clermont 2 , E.<br />
P. Feener 2 , D. Boas 3 , J. G. Fujimoto 1 . 1 Electrical<br />
Engineering, Massachusetts Institute of Technology,<br />
Cambridge, MA; 2 Beetham Eye Institute, Joslin<br />
Diabetes Center, Boston, MA; 3 Athinoula<br />
A. Martinos Center for Biomedical Imaging,<br />
Massachusetts General Hospital, Charlestown, MA<br />
*CR<br />
4895 — D0334 Dynamics of Retinal Pathology<br />
in BALB/cJ Mice Housed in Cyclic Light<br />
Conditions: An Imaging Study to Elucidate<br />
Changes Induced by Long Term Exposure. Brent<br />
A. Bell 1 , C. A. Kaul 1 , I. S. Samuels 1, 2 , V. L. Bonilha 1 ,<br />
M. E. Rayborn 1 , J. G. Hollyfield 1, 3 . 1 Department of<br />
Ophthalmic Research, Cole Eye Institute, Cleveland<br />
Clinic, Cleveland, OH; 2 Research Service, Louis<br />
Stokes Cleveland VA Medical Center, Cleveland,<br />
OH; 3 Department of Ophthalmology, Cleveland<br />
Clinic Lerner College of Medicine at Case Western<br />
Reserve University, Cleveland, OH<br />
4896 — D0335 Microstructural and<br />
physiological alterations in hypoxic-ischemicinjured<br />
visual system. Swarupa Kancherla 1 , K. C.<br />
Chan 1, 2 . 1 UPMC Eye Center, Eye and Ear Institute,<br />
Ophthalmology and Visual Science Research<br />
Center, Department of Ophthalmology, University<br />
of Pittsburgh, Pittsburgh, PA; 2 Department<br />
of Bioengineering, University of Pittsburgh,<br />
Pittsburgh, PA<br />
4897 — D0336 Development of a Rat Model for<br />
Retrobulbar Angiography of X-Ray Computed<br />
Tomography with an Iodine-Containing Polymer.<br />
Kenji Matsushita, R. Kawashima, S. Usui, K.<br />
Nishida. Ophthalmology, Osaka University Medical<br />
School, Suita, Japan *CR<br />
Exhibit Hall D0337-D0355<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Retina<br />
446 Imaging I, RE<br />
Moderators: Michael D. Abramoff, Cynthia A.<br />
Toth and Camiel J. Boon<br />
4898 — D0337 Qualitative and quantitative<br />
changes of cystoid macular edema treated with<br />
Ozurdex therapy. Raeba Mathew 1 , E. Pearce 1, 2 ,<br />
S. Sivaprasad 2, 1 . 1 Ophthalmology, King’s College<br />
Hospital, London, London, United Kingdom;<br />
2<br />
Ophthalmology, Moorfields Eye Hospital, London,<br />
United Kingdom *CR, f<br />
4899 — D0338 Retinal Blood Flow Velocities<br />
in Patients with Retinal Vein Occlusion. Gennady<br />
Landa, N. K. Scripsema, R. B. Rosen. Department of<br />
Ophthalmology, New York Eye and Ear Infirmary,<br />
New York, NY *CR<br />
4900 — D0339 Prediction of visual prognosis<br />
with spectral domain optical coherence<br />
tomography in outer retinal atrophy secondary<br />
to closed-globe trauma. Haoyu Chen, Y. Lu, H.<br />
Huang, J. Zheng, P. Hou, W. Chen. Joint Shantou<br />
International Eye Center, Shantou, China<br />
4901 — D0340 Automated Detection and<br />
Location Analysis of Diabetic Cysts in Retinal<br />
OCT Images: An Iterative Filtering Approach.<br />
Sohini RoyChowdhury 1 , D. D. Koozekanani 2 , S.<br />
Radwan 2, 3 , K. K. Parhi 1 . 1 Electrical Engineering,<br />
University of Minnesota, Minneapolis, MN;<br />
2<br />
Department of Ophthalmology, University of<br />
Minnesota, Mineapolis, MN; 3 Ophthalmology,<br />
Cairo University, Cairo, Egypt *CR<br />
4902 — D0341 Evaluation Of Functional<br />
And Morphological Parameters In Patients<br />
With RVO Treated With Intravitreal Steroid<br />
Implant. Simone Donati, E. Melardi, M. Al<br />
Oum, C. Gandolfi, M. Bianchi, R. Vinciguerra, C.<br />
Azzolini. Department of Morphological and Surgical<br />
Sciences, University of Insubria-Circolo Hospital,<br />
Varese, Italy<br />
4903 — D0342 Macular Thickness Evaluation<br />
in Young Patients With Type 1 Diabetes Mellitus<br />
and Healthy Controls. Muna Al Oum 1 , S. Donati 1 ,<br />
C. Gandolfi 1 , L. Premoli 1 , M. Chiaravalli 1 , M.<br />
Marazza 2 , A. Salvatoni 2 , C. Azzolini 1 . 1 Department<br />
of Surgical and Morphological Science,<br />
University of Insubria-Circolo Hospital, Varese,<br />
Italy; 2 Department of Clinical and Experimental<br />
Medicine, University of Insubria-Del Ponte<br />
Hospital, Varese, Italy<br />
4904 — D0343 Yearly Loss of Retinal<br />
Thickness and Macular Volume Estimated from<br />
SPECTRALIS OCT Measurements in Patients<br />
with Stargardt Macular Dystrophy. Rupert W.<br />
Strauss 1, 2 , E. Fletcher 1, 3 , Y. Wolfson 1 , H. P. Scholl 1 .<br />
1<br />
Wilmer Eye Institute, Johns Hopkins University,<br />
Baltimore, MD; 2 Dept. of Ophthalmology,<br />
Medical University Graz, Graz, Austria; 3 Dept. of<br />
Ophthalmology, Cheltenham General Hospital,<br />
Gloucestershire Hospitals NHS Foundation Trust,<br />
Cheltenham, United Kingdom<br />
4905 — D0344 Choroidal Thickness in Healthy<br />
Pregnant Women Using EDI-OCT. Eric K. Chin,<br />
K. V. Lam, K. Chandra, E. F. Redenbo, S. S. Park.<br />
Ophthalmology, UC Davis Eye Center, Sacramento,<br />
CA<br />
4906 — D0345 Prevalence Of Epiretinal<br />
Membrane In Eyes That Underwent Scleral<br />
Buckle Surgery For Repair Of Primary<br />
Rhegmatogenous Retinal Detachment When<br />
Imaged By SD-OCT. Rosa E. Martinez-Munoz, J.<br />
J. Fromow-Guerra, V. Morales-Canton, V. Franco-<br />
Cardenas. Retina and Vitreous, Asociacion Para<br />
Evitar la Ceguera en Mexico, Mexico, Mexico *CR<br />
4907 — D0346 Clinical Feasibility and<br />
Utility of Ultra Wide-Field Indocyanine<br />
Green Angiography. Thomas L. Berenberg 1 , S.<br />
D. Bhaleeya 1 , M. M. Wessel 1 , M. T. Witmer 1 , S.<br />
Patel 1 , S. R. Sadda 2 , S. Kiss 1 . 1 Ophthalmology,<br />
Weill Cornell Medical College, New York, NY;<br />
2<br />
Ophthalmology, USC Doheny Eye Institute, Los<br />
Angeles, CA *CR<br />
4908 — D0347 Correlation of Posterior<br />
Inflammatory Leakage and Cystoid Macular<br />
Edema with Retinal Pigment Epithelium<br />
Atrophy in Retinitis Pigmentosa Evaluated<br />
with Optos Wide-field Fluorescein Angiography<br />
and Spectral Domain OCT. Carlos A. Medina-<br />
Mendez, M. B. Kaufman, A. W. Eller, T. R. Friberg.<br />
Ophthalmology, University of Pittsburgh Medical<br />
Center, Pittsburgh, PA *CR<br />
4909 — D0348 Correlation between<br />
Visual Acuity and Spectral Domain Optical<br />
Coherence Tomography Findings in Birdshot<br />
Chorioretinopathy Patients. Vincent Y. Ho 1 ,<br />
J. Shantha 1 , F. Forooghian 2 , C. Bergstrom 1 , G.<br />
B. Hubbard 1 , T. W. Olsen 1 , P. Patel 1 , S. Yeh 1 .<br />
1<br />
Ophthalmology, Emory Eye Center, Atlanta, GA;<br />
2<br />
Ophthalmology, St. Paul’s Hospital, Vancouver,<br />
BC, Canada *CR<br />
4910 — D0349 Comparison of Optical<br />
Coherence Tomography Scan Patterns and<br />
Clinical Review Strategies in the Management of<br />
Neovascular Age-related Macular Degeneration.<br />
Robert J. Courtney, J. McClintic, J. P. Ehlers.<br />
Ophthalmology, Cole Eye Institute, Cleveland<br />
Clinic Foundation, Cleveland, OH *CR<br />
4911 — D0350 Perivascular fundus<br />
autofluorescence abnormalities in autoimmune<br />
retinopathy. Damien C. Rodger, G. M. Richter, H.<br />
Nazari Khanamiri, N. A. Rao. Doheny Eye Institute,<br />
Los Angeles, CA<br />
4912 — D0351 The clinical and spectraldomain<br />
optical coherence tomography findings<br />
in focal choroidal excavation. Christopher S.<br />
Lee 1 , S. Woo 2 , D. Hwang 2 , S. lee 1 . 1 Ophthalmology,<br />
Yonsei Univ College of Medicine, Seoul, Republic<br />
of Korea; 2 Ophthalmology, Seoul National Univ<br />
College of Medicine, Seoul, Republic of Korea<br />
4913 — D0352 Wide field imaging in<br />
Coat‘s disease. Carl F. Arndt, S. Masse, K.<br />
Vardi, A. Ducasse, O. Zambrowski. Service<br />
d’Ophthalmologie, Reims University Hospital,<br />
Reims, France *CR<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
313
4914 – 4934 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
4914 — D0353 Reproducibility and<br />
Agreeability of Automated Retinal<br />
Pigment Epithelial Detachment Volumetric<br />
Measurements via Spectral Domain Optical<br />
Coherence Tomography. Joseph Ho 1 , M. Adhi 1 , E.<br />
Cole 1 , J. J. Liu 2 , J. G. Fujimoto 2 , J. S. Duker 1 , N.<br />
K. Waheed 1 . 1 Department of Ophthalmology, Tufts-<br />
New England Eye Center, Boston, MA; 2 Research<br />
Laboratory of Electronics, Massachusetts Institute<br />
of Technology, Cambridge, MA *CR<br />
4915 — D0354 Use of SD-OCT/SLO as an<br />
alternative to ultrasonography to monitor<br />
patients with recurrent retinal detachments<br />
and silicone oil tamponade. Jessica N. Taibl 1, 2 ,<br />
S. I. Sayegh 1 . 1 The EYE Center, Champaign, IL;<br />
2<br />
University of Illinois, Urbana-Champaign, IL<br />
4916 — D0355 Long-term changes of<br />
fudus autofluorescence in central serous<br />
chorioretinopathy. Tetsuju Sekiryu, H. Oyamada,<br />
K. Imaizumi, T. Mori, I. Maruko. Ophthalmology,<br />
Fukushima Medical University, Fukushima, Japan<br />
Exhibit Hall D0356-D0376<br />
<strong>Wednesday</strong>, May 08, 2013 11:00 AM-12:45 PM<br />
Retina<br />
447 DME: OCT and Function<br />
Moderators: Masahiko Shimura and<br />
Francesco Bandello<br />
4917 — D0356 Correlations between Retinal<br />
Morphological Changes and Concentrations of<br />
Cytokines in Eyes with Diabetic Macular Edema.<br />
Shozo Sonoda, T. Yamashita, M. Shirasawa, H.<br />
Otsuka, Y. Sonoda, T. Sakamoto. Department of<br />
Ophthalmology, Kagoshima University, Kagoshima,<br />
Japan<br />
4918 — D0357 Correlation between Diabetic<br />
Macular Edema (DME) and extraocular<br />
complications observed during diabetes.<br />
Olivier Lichtwitz 1 , N. Leveziel 1 , M. Boissonnot 1 ,<br />
A. Miot 2 , X. Piguel 2 , F. Torremocha 2 , P. Saulnier 3 ,<br />
R. Maréchaud 2 , S. Hadjadj 2 . 1 Ophthalmology,<br />
Hospital University of Poitiers, Poitiers, France;<br />
2<br />
Endocrinollogy, Hospital University of Poitiers,<br />
Poitiers, France; 3 Center of Clinical Investigation,<br />
INSERM CIC 802, Poitiers, France *CR<br />
4919 — D0358 Evaluation of choroidal<br />
thickness by enhanced depth imaging OCT in<br />
the LUCIDATE study: a randomised clinical<br />
trial to compare outcomes of ranibizumab<br />
with laser in diabetic macular oedema. Rishma<br />
Gohil 1, 2 , O. Comyn 1 , P. A. Keane 1 , P. J. Patel 1 , J. W.<br />
Bainbridge 1 , S. Sivaprasad 1, 2 , P. G. Hykin 1 . 1 NIHR<br />
Biomedical Research Centre at Moorfields Eye<br />
Hospital NHS Foundation Trust and UCL Institute<br />
of Ophthalmology, London, United Kingdom;<br />
2<br />
King’s College London, London, United Kingdom<br />
*CR, f<br />
4920 — D0359 Chromatic sensitivity in<br />
diabetic patients treated with Ozurdex. Ahmed<br />
F. Abdel-hay 1, 2 , S. Sivaprasad 1 , A. Subramanian 2 ,<br />
E. Konstantakopoulou 2 , D. F. Edgar 2 , J. L. Barbur 2 .<br />
1<br />
Ophthalmology, King’s College Hospital, London,<br />
United Kingdom; 2 1Applied Vision Research<br />
Centre, City University London, London, United<br />
Kingdom *CR, f<br />
4921 — D0360 Longitudinal Comparison of<br />
Visual Acuity as Measured by ETDRS Chart and<br />
by Potential Acuity Meter in Eyes with Macular<br />
Edema and Its Relationship with Macular<br />
Sensitivity and Thickness. Elham Hatef Naimi 1, 2 ,<br />
M. Hanout 1 , O. O. Agbedia 1 , A. Moradi 1 , D. V.<br />
Do 1 , D. L. Guyton 1 , Q. Nguyen 1 . 1 Ophthalmology,<br />
Wilmer Eye Inst, Johns Hopkins Univ, Baltimore,<br />
MD; 2 General Preventive Medicine, Johns Hopkins<br />
Bloomberg School of Public Health, Baltimore,<br />
MD *CR<br />
4922 — D0361 Retinal Perifoveal Inner<br />
Layer Disorganization as a Predictor of Visual<br />
Acuity Outcomes in Eyes with Center-involved<br />
Diabetic Macular Edema. Michael M. Lin 1, 7 , R.<br />
Sarangi 1, 2 , J. Lammer 1, 3 , A. Y. Ganjei 1 , S. Radwan 4,<br />
5<br />
, A. Z. Soliman 4, 5 , P. S. Silva 1, 6 , L. P. Aiello 1,<br />
6<br />
, J. K. Sun 1, 6 . 1 Beetham Eye Institute, Joslin<br />
Diabetes Center, Boston, MA; 2 Boston University<br />
School of Medicine, Boston, MA; 3 Department<br />
of Ophthalmology and Optometry, Medical<br />
University Vienna, Vienna, Austria; 4 Department<br />
of Ophthalmology, University of Minnesota,<br />
Minneapolis, MN; 5 Department of Ophthalmology,<br />
Cairo University, Cairo, Egypt; 6 Department of<br />
Ophthalmology, Harvard Medical School, Boston,<br />
MA; 7 Harvard Medical School, Boston, MA *CR<br />
4923 — D0362 The effect of hard exudates<br />
and epiretinal fibrosis on the retinal thickness<br />
as calculated by optical coherence tomography<br />
(OCT) in diabetic macular edema. Delila Hodzic 1 ,<br />
B. A. Sander 1 , H. Lund-Andersen 1, 2 . 1 Department<br />
of ophthalmology, Glostrup Hospital, Glostrup,<br />
Denmark; 2 Faculty of Health Sciences, University<br />
of Copenhagen, Copenhagen, Denmark<br />
4924 — D0363 Correlation of structural and<br />
visual function tests in patients with diabetic<br />
macular edema. Elizabeth Pearce, R. Mathew, A.<br />
F. Abdel-hay, S. Sivaprasad. Ophthalmology, King’s<br />
College Hospital, London, United Kingdom *CR, f<br />
4925 — D0364 Retinal Layer Thicknesses<br />
in SDOCT Images for Diabetics with Hard<br />
Exudates. Joel A. Papay 1 , A. E. Elsner 1 , C. A.<br />
Clark 1 , V. Malinovsky 1 , S. G. Brahm 1 , S. B. Young 1 ,<br />
A. V. Walker 1 , T. V. Litvin 2 , G. Y. Ozawa 2 , J. A.<br />
Cuadros 2 . 1 School of Optometry, Indiana University,<br />
Bloomington, IN; 2 School of Optometry, UC<br />
Berkeley, Berkeley, CA *CR<br />
4926 — D0365 Retinal thickness reduction<br />
and layers involvement in different diseases<br />
visualized by SD-OCT. Michele M. Iester 1 , L.<br />
Borgia 2 . 1 DiNOGMI, University of Genoa, Genova,<br />
Italy; 2 Is.Pre Oftalmica, Genoa, Italy<br />
4927 — D0366 Visual acuity evaluation in<br />
patients treated with ranibizumab for diabetic<br />
macular edema. Marc Stahel 1 , P. P. Ciechanowski 1 ,<br />
F. Moser 1 , S. Lortz 1 , H. M. Fassnacht 1 , N. T. Graf 2 ,<br />
M. D. Becker 1 , S. Michels 1 . 1 Ophthalmology,<br />
Triemli Hospital Zurich, Zurich, Switzerland; 2 Graf<br />
Biostatistics, Winterthur, Switzerland *CR<br />
4928 — D0367 Differences in the topographic<br />
profile of retinal thickening in cases of diabetic<br />
macular edema with and without serous<br />
macular detachment. Hannah Shereef 1, 4 , O.<br />
Comyn 2 , S. Sivaprasad 2 , P. G. Hykin 2 , G. C.<br />
Cheung 3 , N. Narendran 4 , Y. C. Yang 4 . 1 University<br />
of Birmingham, Birmingham, United Kingdom;<br />
2<br />
National Institute for Health Research Biomedical<br />
Research Centre at Moorfields Eye Hospital<br />
NHS Foundation Trust and UCL Institute of<br />
Ophthalmology, London, United Kingdom;<br />
3<br />
Singapore National Eye Centre, Singapore,<br />
Singapore; 4 Royal Wolverhampton Hospitals NHS<br />
Trust, Wolverhampton, United Kingdom *CR<br />
4929 — D0368 Use of a Retinal Acuity Meter<br />
(RAM) and Brightness Acuity Meter (BAM) to<br />
Identify Early Diabetic Macular Edema. Albert<br />
Li, D. J. Sackel, A. Chen, L. Park. Ophthalmology,<br />
NYU School of Medicine, New York, NY<br />
4930 — D0369 Optimal treatment strategy<br />
for Stage 5 Type 2A Idiopathic Macular<br />
Telangiectasia with anti-vascular endothelial<br />
growth factor (VEGF) agents - When to stop?<br />
Sharad S. Malavade, S. Cohen. Ophthalmology,<br />
University of South Florida, Tampa, FL<br />
4931 — D0370 Safety, sterility and stability of<br />
direct- from- vial multiple dosing intravitreal<br />
injection of bevacizumab. Taraprasad Das 1 , S.<br />
Volety 2 , S. M. Ahsan 2 , A. K. Thakur 2 , S. Sharma 1 ,<br />
S. Basu 1 , T. R. Padhi 1 , M. Rao 2 . 1 Retina Vitreous<br />
Services, LV Prasad Eye Institute, Bhubaneswar,<br />
India; 2 Center for Cellular and Molecular Biology,<br />
Hyderabad, India<br />
4932 — D0371 Increased Healthcare Cost<br />
Related To Adding Dexamethasone Implant<br />
(Ozurdex ® ) To Bevacizumab (Avastin ® )<br />
Monotherapy In Patients With Cystoid Macular<br />
Edema (CME) Due To Retinal Vein Occlusion<br />
(RVO) May Be Balanced By Less Frequent<br />
Follow-Up. Omar Saleh, J. Heroman, S. Schaal.<br />
University of Louisville, Louisville, KY<br />
4933 — D0372 Reperfusion of ischemia with<br />
central retinal vein occlusion by activated<br />
protein C. Motohiro Kamei, N. Matsumura, M.<br />
Suzuki, S. Sakimoto, H. Sakaguchi, K. Nishida.<br />
Ophthalmology, Osaka Univ Grad School of<br />
Medicine, Suita, Japan *CR, f<br />
4934 — D0373 The Efficacy of Single<br />
Intravitreal Ranibizumab Injection in Acute<br />
Nonarteritic Ischemic Optic Neuropathy. Ali<br />
Osman Saatci, O. Taskin, O. Barut Selver, A. Yaman,<br />
M. Soylev Bajin. Ophthalmology Department,<br />
Dokuz Eylul University, Izmir, Turkey<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
314
<strong>Wednesday</strong> – Posters – 4935 – 4937<br />
4935 — D0374 Influence of Axial Length<br />
and Degree of Injection Reflux on Sustained<br />
Intraocular Pressure Elevation Due to<br />
Intravitreal Anti-Vascular Endothelial<br />
Growth Factor Therapy. Luis Mendonca 1, 2 , Q.<br />
V. Hoang 2, 3 , J. J. Jung 4 , S. Mrejen 2 , K. Freund 2,<br />
3<br />
. 1 Ophthalmology, Hospital de Braga, Braga,<br />
Portugal; 2 Vitreous, Retina, Macula Consultants<br />
of New York, New York, NY; 3 Ophthalmology,<br />
Columbia University Medical Center, New York,<br />
NY; 4 Ophthalmology, New York University, New<br />
York, NY *CR<br />
4936 — D0375 Ranibizumab versus<br />
Bevacizumab in the treatment of subfoveal<br />
choroidal neovascular membrane secondary<br />
to pathologic myopia. Ramón Domínguez<br />
Fernández 1 , A. Govetto 1 , M. Alves Perez 2 , R.<br />
Lorente 1 . 1 Ophthalmology, CHU Ourense, Ourense,<br />
Spain; 2 Biostatistics, CHU Ourense, Ourense, Spain<br />
4937 — D0376 Changes in retinal layer<br />
morphology following intra-vitreal Ozurdex<br />
therapy for macular oedema secondary to<br />
Retinal Vein Occlusion. Rashmi Akshikar, S.<br />
Sivaprasad. Ophthalmology, Kings College<br />
Hospital London, London, United Kingdom *CR<br />
<strong>Wednesday</strong> Posters<br />
11:00 am – 12:45 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
315
<strong>Wednesday</strong> – Workshop/SIGs<br />
TCC 304<br />
<strong>Wednesday</strong>, May 08, 2013 1:00 PM-2:30 PM<br />
Multidisciplinary Ophthalmic Imaging<br />
448 Multidisciplinary Ophthalmic<br />
Imaging Group: Functional<br />
Optical Imaging<br />
606/607<br />
<strong>Wednesday</strong>, May 08, 2013 1:00 PM-2:30 PM<br />
449 Managing Your Research, Teaching<br />
and Service: “Dollarly/Scholarly”<br />
611-614<br />
<strong>Wednesday</strong>, May 08, 2013 1:00 PM-2:30 PM<br />
450 Getting Published: The Good, the<br />
Bad, and the Ugly<br />
<strong>Wednesday</strong> Workshops/<br />
SIGs<br />
1:00 pm – 2:30 pm<br />
Optical techniques are known to provide high<br />
resolution images of tissue structures. Technological<br />
advances in optical coherence tomography,<br />
scanning laser ophthalmoscopy, photoacoustic<br />
ophthalmoscopy now provide means for imaging<br />
function as well. The possible functional<br />
measurements include ocular blood flow, oxygen<br />
tension, and their responses to visual stimulation.<br />
These techniques are useful for in vivo investigation<br />
in both animals and humans. Clinical applications<br />
may be possible in the future.<br />
Moderators: Joel S. Schuman, David Huang<br />
and Gadi Wollstein<br />
— 1:00 Introduction<br />
— 1:05 Laser Speckle Flowgraphy in<br />
Glaucoma. Toru Nakazawa. Ophthalmology,<br />
Tohoku Univ Graduate Sch of Med, Sendai, Japan<br />
*CR<br />
— 1:20 Dual-beam Bidirectional OCT. Leopold<br />
Schmetterer. Clinical Pharmacology, Medical<br />
University of Vienna, Vienna, Austria<br />
— 1:35 Erythrocyte Velocity Measurement<br />
with Adaptive Optics Scanning Laser<br />
Ophthalmoscopy. Stephen A. Burns. School of<br />
Optometry, Indiana University, Bloomington, IN<br />
— 1:50 Retinal Oxymetry by Photoacoustic<br />
Ophthalmoscopy. Hao F. Zhang. Biomedical<br />
Engineering, Northwestern University, Evanston,<br />
IL *CR<br />
— 2:05 Retinal Oxygen Tension Imaging.<br />
Mahnaz Shahidi. Ophthalmology & Visual<br />
Sciences, University of Illinois at Chicago, Chicago,<br />
IL *CR<br />
— 2:20 Discussion/Business Meeting<br />
Managing time commitments is an extremely<br />
important skill needed to accomplish your<br />
professional goals. As a faculty member in a<br />
research university, the three major areas of work<br />
are 1) research, 2) teaching, and 3) committee/<br />
community service. For those in industry research<br />
positions, personnel management may replace<br />
teaching as a component of your job. The level of<br />
success in these areas plays a major role in your<br />
personnel evaluations and your promotions. This<br />
is an area of professional life that is rarely taught<br />
in formal presentations. As a young professional,<br />
from a diverse background (a woman or, a<br />
minority, or both), you will find yourself pulled<br />
in various directions as many people want you<br />
to serve on their different committees, in order<br />
to meet institutional diversity requirements. This<br />
workshop will concentrate on managing your time<br />
and effort, both quantitatively and qualitatively, to<br />
achieve success in all three areas. Implicit in this<br />
management effort is success in providing time for<br />
yourself and family. The invited speaker(s) will<br />
address their own experiences, challenges, failures<br />
and successes in this critical area of professional<br />
life. From their life experience, you may gain<br />
valuable knowledge and skills to navigate this<br />
important aspect of your life.<br />
Moderators: Jerome Wujek and Joseph Carroll<br />
— 1:00 Introduction<br />
— 1:05 Presentation. Janey L. Wiggs.<br />
Ophthalmology-Harvard Med Sch, Mass Eye & Ear<br />
Infirmary, Boston, MA<br />
— 1:17 Presentation. Emily Y. Chew.<br />
Epidemiology & Clinical Applications, National<br />
Eye Inst/NIH, Bethesda, MD<br />
— 1:29 Presentation. Terri L. Young.<br />
Ophthalmology, Duke University Eye Center,<br />
Durham, NC *CR<br />
— 1:41 Presentation. Nisha Acharya. Ophthal-<br />
Proctor Foundation, Univ of California - SF, San<br />
Francisco, CA<br />
— 1:53 Presentation. Cynthia L. Grosskreutz.<br />
Ophthalmology, Novartis Inst for Biomed Resrch,<br />
Cambridge, MA *CR<br />
— 2:05 Discussion<br />
This workshop will focus on practical and<br />
ethical issues relevant to publishing and the peer<br />
review process, addressing the responsibilities<br />
of both authors and reviewers. Topics will<br />
include: plagiarism, its definition, detection,<br />
and consequences; the elements of a “good”<br />
(constructive) review, and things to avoid when<br />
writing reviews; reviewer conflicts of interest, and<br />
maintaining confidentiality.<br />
Moderators: Steven J. Fliesler and<br />
Ron A. Adelman<br />
— 1:00 Introduction<br />
— 1:05 Authorship Ethics: Plagiarism -<br />
Walking on the Dark Side. Steven J. Fliesler.<br />
Ophthalmology, SUNY-Buffalo / VA Med Ctr-<br />
Buffalo, Buffalo, NY<br />
— 1:30 Good Reviews, Bad Reviews: How to<br />
Do One and Not the Other. Jeffrey H. Boatright.<br />
Ophthalmology, Emory University School of Med,<br />
Atlanta, GA<br />
— 1:55 Reviewer Ethics: Doing the Right<br />
Thing. David C. Beebe. Ophthalmol & Visual Sci,<br />
Washington Univ, St Louis, MO *CR<br />
— 2:20 Discussion<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
316
<strong>Wednesday</strong> – Workshops/SIGs<br />
615-617<br />
<strong>Wednesday</strong>, May 08, 2013 1:00 PM-2:30 PM<br />
451 Indo-US Collaborative Vision<br />
Research Program<br />
TCC 301/302<br />
<strong>Wednesday</strong>, May 08, 2013 1:00 PM-2:30 PM<br />
452 Pizza with the Experts #2<br />
6A<br />
<strong>Wednesday</strong>, May 08, 2013 1:00 PM-2:30 PM<br />
Retinal Cell Biology / Retina<br />
454 What Role Do Mueller Glial Cells<br />
Play in Retinal Pathology? - SIG<br />
The Indo-U.S. Collaborative Vision Research<br />
Program has supported more than a dozen<br />
collaborative and productive relationships since its<br />
formalization in 2005. The representatives of the<br />
governments of India and the U.S. have worked<br />
together to create a number of opportunities for<br />
the vision researchers to jointly submit and receive<br />
funding to pursue projects on genetic ocular traits,<br />
cataract, glaucoma, diabetic retinopathy, retinal<br />
degeneration and neuroplasticity. The program is<br />
supported by the R01 research grant at NIH and<br />
an award mechanism supported by the Department<br />
of Biotechnology, Government of India. Leading<br />
vision researchers from the US and India will<br />
discuss the current programs, future opportunities,<br />
award mechanisms, various challenges and ways<br />
to achieve successful results in a collaborative<br />
program across the globe. The participants will have<br />
the opportunity to learn about the scientific projects<br />
sponsored through the bilateral research program.<br />
Moderators: Gyan Prakash and T.S. Rao<br />
— 1:00 Intervational Vision Research. Paul A.<br />
Sieving. National Eye Institute, Bethesda, MD<br />
— 1:12 Overview of Application Process<br />
for Indo-US Vision Research Program. Gyan<br />
Prakash. National Eye Institute, NIH, Bethesda,<br />
MD<br />
— 1:24 Vision Research Projects -<br />
Collaborative Case Studies. C M. Rao. Center for<br />
Cell & Molec Biology, Hyderabad, India<br />
— 1:36 Indo-US Programs: Challenges and<br />
Benefits of the Bilateral Scientific Research<br />
Opportunities. Nandita Chopra. Dept. of Health &<br />
Human Services, US Embassy, Bethesda, MD<br />
— 1:48 India US Genetic Study of<br />
Ocular Quantitative Traits. Janey L. Wiggs.<br />
Ophthalmology-Harvard Med Sch, Mass Eye & Ear<br />
Infirmary, Boston, MA<br />
— 2:00 Diabetic Retinopathy - The Looming<br />
Global Health Crisis. P. Namperumalsamy.<br />
Research, Aravind Medical Research Foundation,<br />
Madurai, India<br />
— 2:12 Discussion<br />
Advance registration required. Trainees,<br />
students and junior faculty, don’t miss this<br />
unique opportunity to network and gain valuable<br />
information from those who have been in your<br />
shoes! This very popular program offers informal<br />
discussions over a pizza lunch on a wide range of<br />
topics to provide personal guidance, insight and<br />
skills to help you advance your career! Topics will<br />
focus on professional development, career guidance,<br />
and best practices of interest to basic and clinical<br />
trainees and clinician-scientists. A number of the<br />
roundtable topics will be specifically tailored to the<br />
needs of clinician-scientists.<br />
TCC 303<br />
<strong>Wednesday</strong>, May 08, 2013 1:00 PM-2:30 PM<br />
453 NIH-CSR Peer Review Workshop<br />
Sponsored by the NIH Center for Scientific Review<br />
(CSR), this workshop is designed to inform grant<br />
applicants and also reviewers about the NIH peer<br />
review process and the changes that have occurred,<br />
including the recent reorganization of study sections<br />
that review visual system grant applications.<br />
Scientific Review Officers (SROs) from CSR will<br />
be on hand for the presentation and will be available<br />
to answer questions.<br />
Moderator: Michael H. Chaitin<br />
— 1:00 Overview: Peer Review<br />
— 1:20 Biology of the Visual System (BVS)<br />
Study Section. Michael H. Chaitin. Center for<br />
Scientific Review, NIH, Bethesda, MD<br />
— 1:30 Diseases and Pathophysiology of the<br />
Visual System (DPVS) Study Section. Nataliya<br />
V. Gordiyenko. Center for Scientific Review, NIH,<br />
Bethesda, MD<br />
— 1:40 Small Business: Sensory Technologies<br />
[ETTN-12] Study Section. Paek-Gyu Lee. Center<br />
for Scientific Review, NIH, Bethesda, MD<br />
— 1:50 Bioengineering of Neuroscience, Vision,<br />
and Low Vision Technologies (BNVT) Study<br />
Section. Robert C. Elliott. Center for Scientific<br />
Review, NIH, Bethesda, MD<br />
— 2:00 Title - to be determined by author.<br />
Maqsood A. Wani. NIH, Bethesda, MD<br />
— 2:10 Panel Discussion<br />
Very little is known about the contribution of<br />
Mueller cells to the pathogenesis of retinal<br />
disease. Evidence will be presented suggesting<br />
that Mueller cell dysfunction may result in key<br />
vision-threatening events, such as photoreceptor<br />
degeneration and retinal edema.<br />
Moderators: Marcus Fruttiger and G Astrid Limb<br />
— 1:00 SIG Organizer. Mark C. Gillies.<br />
Ophthalmology, University of Sydney, Sydney,<br />
NSW, Australia *CR<br />
— SIG Organizer. Francine F. Behar-Cohen.<br />
Ophthalmology, Hotel Dieu de Paris, Universite<br />
Paris Descartes, Paris, France *CR<br />
— Consequences of Selective Muller cell<br />
Ablation in a Transgenic Model. Mark C. Gillies.<br />
Ophthalmology, University of Sydney, Sydney,<br />
NSW, Australia *CR<br />
— Glia in Retinal Vascular Disease. Erica L.<br />
Fletcher. Dept Anatomy/Neuroscience, University<br />
of Melbourne, Parkville, VIC, Australia *CR<br />
— Retinal Glia: Novel Mineralocorticoid<br />
Targets. Francine F. Behar-Cohen. Ophthalmology,<br />
Hotel Dieu de Paris, Universite Paris Descartes,<br />
Paris, France *CR<br />
6B<br />
<strong>Wednesday</strong>, May 08, 2013 1:00 PM-2:30 PM<br />
Retina<br />
455 Diabetic Retinopathy: Where We<br />
Are and a Path to Progress - SIG<br />
The Lasker/IRRF Initiative explored diabetic<br />
retinopathy, a serious ocular complication of<br />
diabetes mellitus, and the possible connection<br />
between the rise in blood glucose levels to changes<br />
in neuronal/glial function and to vascular changes<br />
that eventually can destroy vision in the eye.<br />
Moderator: John E. Dowling<br />
— SIG Organizer. John E. Dowling. Molecular<br />
and Cellular Biology, Harvard University,<br />
Cambridge, MA<br />
— Vascular and Neuronal Repair. Robert N.<br />
Frank. Ophthalmology, Wayne State Univ/Kresge<br />
Eye Inst, Detroit, MI<br />
— Early Signs of Diabetic Retinopathy. Thomas<br />
W. Gardner. Ophthalmology, Kellogg Eye Ctr Univ<br />
of Michigan, Ann Arbor, MI *CR<br />
Wednesda Workshops/<br />
SIGs<br />
1:00 pm – 2:30 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
317
<strong>Wednesday</strong> – Workshop/SIGs<br />
<strong>Wednesday</strong> Workshops/<br />
SIGs<br />
1:00 pm – 2:30 pm<br />
— Role of Glucose, Lipids and Oxygen<br />
in Diabetic Retinopathy. Timothy S. Kern.<br />
Department of Medicine, Case Western Reserve<br />
Univ, Cleveland, OH *CR<br />
— Diagnostic Methods. Larry A. Donoso.<br />
Research, Philadelphia Retina Endowment Fund,<br />
Philadelphia, PA<br />
— Present and Proposed Approaches to<br />
Therapeutics. Lloyd M. Aiello. Beetham Eye<br />
Institute, Joslin Diabetes Center, Boston, MA<br />
6C<br />
<strong>Wednesday</strong>, May 08, 2013 1:00 PM-2:30 PM<br />
Retinal Cell Biology<br />
456 Epigenetic Mechanism and Ocular<br />
Diseases - SIG<br />
The SIG will update the research of epigenetic<br />
modifications in diabetic retinopathy, retinal<br />
development, corneal dystrophy, AMD and PVR<br />
and the roles of DNA-methylation, histoneacetylation<br />
and miRNA in the pathogenesis of<br />
these diseases and its treatment by epigenetic<br />
intervention.<br />
Moderator: Renu A. Kowluru<br />
— SIG Organizer. Renu A. Kowluru.<br />
Ophthalmology, Wayne State Univ/Kresge Eye Inst,<br />
Detroit, MI<br />
— Histone modifications in diabetic retinopathy.<br />
Renu A. Kowluru. Ophthalmology, Wayne State<br />
Univ/Kresge Eye Inst, Detroit, MI<br />
— DNA Methylation in RPE Transdifferentiation<br />
and its relevance to proliferative<br />
vitreoretinopathy. Shikun He. Ophthalmology-<br />
USC, Doheny Eye Institute, Los Angeles, CA<br />
— When Good RPE Break Bad: A meta-genomic<br />
analysis of chronic RPE stress and aging.<br />
Monte Radeke. Neuroscience Research Institute,<br />
University of California, Santa Barbara, CA<br />
— Epigenetic factors in the pathogenesis of<br />
corneal dystrophy. Xiaohua Li. Henan eye institue,<br />
Zhengzhou, China<br />
— Histone modification in regulation of retinal<br />
development. Dong F. Chen. Ophthalmology/<br />
Harvard, Schepens Eye Res Inst, Harvard Med Sch,<br />
Boston, MA *CR<br />
— DNA methylation in regulation of retinal<br />
development. Shannath L. Merbs. Ophthalmology,<br />
Wilmer Eye Institute, Johns Hopkins Univ,<br />
Baltimore, MD<br />
618-620<br />
<strong>Wednesday</strong>, May 08, 2013 1:00 PM-2:30 PM<br />
Cornea / Biochemistry/Molecular Biology /<br />
Glaucoma / Retina<br />
457 Dietary Factors and Eye Health -<br />
SIG<br />
There is growing interest in dietary factors and<br />
supplements that may have protective effects<br />
against eye diseases. This SIG will focus on<br />
nutritional factors which are beneficial for the<br />
eye. Exciting new research data and potential<br />
mechanisms will be presented and discussed.<br />
Moderators: Kazuo Tsubota and Rajendra S. Apte<br />
— SIG Organizer. Kazuo Tsubota. Ophthalmology,<br />
Keio Univ School of Medicine, Shinjuku-ku, Japan<br />
*CR<br />
— Lutein, Zeaxanthin, and Omega-3 Fatty<br />
Acid Function in the Human Macula: The Basic<br />
Science Underlying AREDS2. Paul S. Bernstein.<br />
Ophthal and Visual Sciences, Univ of Utah/Moran<br />
Eye Center, Salt Lake City, UT *CR<br />
— The Protective Effects of Resveratrol are<br />
Mediated through Forkhead Box O Activity.<br />
Pratap Challa. Dept of Ophthalmology, Duke<br />
University Eye Center, Durham, NC<br />
— Omega-3 and Macular Pigment<br />
Accumulation: Results from the PIMAVOSA<br />
Study. Marie-Noelle Delyfer. Ophthalmology,<br />
Hopital Pellegrin, Bordeaux, France *CR<br />
— The Novel Potential of Lactoferrin for Ocular<br />
Surface Health. Motoko Kawashima. Department<br />
of Ophthalmology, Keio University School of<br />
Medicine, Shinjuku ku, Japan *CR<br />
TCC LL 4/5<br />
<strong>Wednesday</strong>, May 08, 2013 1:00 PM-2:30 PM<br />
Retina<br />
458 New Paradigms and Emerging<br />
Techniques for Minimalist Macular<br />
Photocoagulation - SIG<br />
Laser treatments for macular edema have shifted<br />
toward minimal invasiveness in the era of anti-<br />
VEGF therapy. Various techniques including<br />
micropulsing, nanopulsing, and navigated<br />
microaneurysm treatment will be discussed.<br />
Moderators: William R. Freeman, Johann Roider,<br />
Bert M. Glaser and Giovanni Staurenghi<br />
— SIG Organizer. Richard B. Rosen.<br />
Ophthalmology, New York Eye & Ear Infirmary,<br />
New York, NY *CR<br />
— Navigated Laser Therapy. William R. Freeman.<br />
Ophthalmology, UCSD Jacobs Retina Center, La<br />
Jolla, CA *CR<br />
— Nanopulse Laser Therapy. Johann Roider.<br />
Klinik fur Ophthalmologie, University of Kiel, Kiel,<br />
Germany *CR<br />
— Micropulse Laser Therapy. Bert M. Glaser.<br />
Ocular Proteomics, National Retina Institute,<br />
Towson, MD *CR<br />
— Feeder Vessel Therapy. Giovanni Staurenghi.<br />
Dept of Biomedical and Clinical Science (Luigi<br />
Sacco), University of Milan, Milano, Italy *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
318
6B<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Glaucoma<br />
459 Neuroprotection<br />
6C<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Retina<br />
460 ROP: Management<br />
4938 – 4958 – <strong>Wednesday</strong> – Papers/Minisymposium<br />
4951 — 4:15 Use of Computer-Assisted<br />
Quantitative Analysis of Retinal Vascular<br />
Dilation and Tortuosity to Predict Need for<br />
Laser Treatment in Retinopathy of Prematurity.<br />
Katherine Wu 1 , D. Wallace 2 , S. F. Freedman 2 .<br />
1<br />
School of Medicine, Duke University, Durham,<br />
NC; 2 Ophthalmology and Pediatrics, Duke<br />
University, Durham, NC *CR<br />
Moderators: Leonard A. Levin, Robert W. Nickells<br />
and M Francesca Cordeiro<br />
4938 — 2:45 Ocular Hypotensive and<br />
Neuroprotective Effects of Agmatine. Samin<br />
Hong. Ophthalmology, Yonsei University College<br />
of Medicine, Seoul, Republic of Korea<br />
4939 — 3:00 The Jigsaw Effect: Clinical<br />
Evidence for CNS Control of Visual Field Loss<br />
in Chronic Glaucoma. Willliam E. Sponsel 1, 2 ,<br />
N. Satsangi 3 , M. A. Reilly 1 , S. L. Groth 4 , S. J.<br />
McKinnon 5 . 1 Biomedical Engineering, University<br />
of Texas - San Antonio, San Antonio, TX;<br />
2<br />
Madison Square Bldg Ste 306, WESMDPA, San<br />
Antonio, TX; 3 School of Medicine, University of<br />
Texas Health Science Center - San Antonio, San<br />
Antonio, TX; 4 School of Medicine, University of<br />
Minnesota, Minneapolis, MN; 5 Ophthalmology and<br />
Neurobiology, Duke University, Durham, NC *CR<br />
4940 — 3:15 AAV-Mediated Neurotrophin-4<br />
Is Neuroprotective In Murine Model<br />
Of Microbead-Induced Glaucoma with<br />
Neurotrophin Expression in the Visual Pathway.<br />
Anna M. Demetriades, L. Guo, C. Pan. Glaucoma<br />
Research Laboratory, Weill Cornell Medical<br />
College, New York, NY<br />
4941 — 3:30 The Effect of Modulators of<br />
Microtubule Stability on Dendritic Morphology<br />
in Cultured Retinal Ganglion Cells. Rachel<br />
Chong 1 , B. Lorber 1 , K. R. Martin 1, 2 . 1 John Van<br />
Geest Centre for Brain Repair, University of<br />
Cambridge, Cambridge, United Kingdom; 2 NIHR<br />
Biomedical Research Centre, University of<br />
Cambridge, Cambridge, United Kingdom<br />
4942 — 3:45 Enhanced retinal ganglion<br />
cell survival in glaucoma by hypoxic<br />
postconditioning after disease onset. Yanli Zhu 1 ,<br />
L. Zhang 1 , C. Chiang 2 , J. Gidday 1 . 1 Neurosurgery,<br />
Washington Univ Sch of Med, St Louis, MO;<br />
2<br />
Radiology, Washington Univ Sch of Med, St.<br />
Louis, MO<br />
4943 — 4:00 Neuroprotection from excitotoxic<br />
RGC death: is there a role for MMPs? Lies<br />
De Groef, M. A. Salinas-Navarro, E. Dekeyster,<br />
K. Lemmens, D. Gaublomme, I. Van Hove, L. K.<br />
Moons. Department of Biology, Laboratory for<br />
Neural Circuit Development and Regeneration, KU<br />
Leuven, Leuven, Belgium<br />
4944 — 4:15 TrkB Receptor Agonists as<br />
Neuroprotective Molecules in Glaucoma -Effect<br />
of 7,8 Dihydroxyflavone. Stuart Graham 1, 2 , Y.<br />
You 1 , J. C. Li 1 , V. Gupta 1 . 1 Australian School of<br />
Advanced Medicine, Macquarie University, Sydney,<br />
NSW, Australia; 2 Save Sight Institute, Sydney<br />
University, Sydney, NSW, Australia<br />
Moderator: R.V. Paul Chan<br />
4945 — 2:45 Length of daylight during early<br />
gestation is an independent predictor of risk<br />
for severe retinopathy of prematurity. Michael<br />
B. Yang 1, 2 , S. Rao 1 , D. R. Copenhagen 3, 4 , R. A.<br />
Lang 1, 2 . 1 Ophthalmology/Visual Systems Group/<br />
Abrahamson Pediatric Eye Institute, Cincinnati<br />
Children’s Hospital Medical Center, Cincinnati,<br />
OH; 2 Ophthalmology, University of Cincinnati,<br />
Cincinnati, OH; 3 Ophthalmology, University of<br />
California San Francisco, San Francisco, CA;<br />
4<br />
Physiology, University of California San Francisco,<br />
San Francisco, CA *CR<br />
4946 — 3:00 Long term outcomes of lens<br />
clarity following lens-sparing vitrectomy for<br />
retinopathy of prematurity. Eric Nudleman, A.<br />
Capone, K. A. Drenser, M. T. Trese. Associated<br />
Retinal Consultants, William Beaumont Hospital,<br />
Royal Oak, MI *CR<br />
4947 — 3:15 Risk factors for retinopathy of<br />
prematurity (ROP): insights from “outlier”<br />
infants with low or high birth weights. Alexander<br />
D. Port 1 , R. Chan 2 , S. Ostmo 3 , M. F. Chiang 3, 4 .<br />
1<br />
Weill Cornell Medical College, New York, NY;<br />
2<br />
Ophthalmology, Weill Cornell Medical College,<br />
New York, NY; 3 Ophthalmology, Oregon Health<br />
& Science University, Portland, OR; 4 Medical<br />
Informatics and Clinical Epidemiology, Oregon<br />
Health & Science University, Portland, OR *CR<br />
4948 — 3:30 The postnatal weight-gain<br />
algorithm WINROP early identifies sight<br />
threatening retinopathy of prematurity in<br />
a nation based cohort of extremely preterm<br />
infant. Pia Lundgren 1, 2 , E. Stoltz Sjöström 3 , M.<br />
Domellöf 3 , G. Holmström 4 , A. Hård 2 , C. Lofqvist 2 ,<br />
A. Hellström 2 . 1 Ophthalmology, Umeå University,<br />
Umeå, Sweden; 2 Ophthalmology, Sahlgrenska<br />
academy at University of Gothenburg, Gothenburg,<br />
Sweden; 3 Pediatrics, Umeå University, Umeå,<br />
Sweden; 4 Ophthalmology, Uppsala University,<br />
Uppsala, Sweden *CR<br />
4949 — 3:45 Detection of Threshold<br />
Retinopathy of Prematurity using the PINT-ROP<br />
Growth Model. Anupam Kumar, D. Morrison.<br />
Vanderbilt University School of Medicine,<br />
Nashville, TN *CR<br />
4950 — 4:00 Feasibility of Color Doppler<br />
Spectral Domain Optical Coherence<br />
Tomography in premature infants undergoing<br />
Retinopathy of Prematurity screening. Ramiro<br />
S. Maldonado 1 , E. L. Yuan 1 , D. Tran-Viet 1 , S. F.<br />
Freedman 1, 2 , D. Wallace 1, 2 , H. C. Hendargo 3 ,<br />
J. A. Izatt 3 , C. A. Toth 1, 3 . 1 Duke University Eye<br />
Center, Durham, NC; 2 Pediatrics, Duke University<br />
School of Medicine, Durham, NC; 3 Biomedical<br />
Engineering, Duke University, Durham, NC *CR<br />
6E<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Retina<br />
461 Retinal Detachment II<br />
Moderators: Toshinori Murata and<br />
Ron A. Adelman<br />
4952 — 2:45 The Management of Retinal<br />
Detachments in Patients with Severe Mental<br />
Disabilities. Kirk H. Packo 1 , J. M. Civantos 1 , J. A.<br />
Cohen 1 , J. S. Pollack 1 , P. T. Merrill 1 , S. de Bustros 1 ,<br />
B. Garretson 2 . 1 Ophthalmology, Rush University<br />
Medical Center, Chicago, IL; 2 Ophthalmology,<br />
Oakland University William Beaumont School of<br />
Medicine, Royal Oak, IL *CR<br />
4953 — 3:00 Management of Uncomplicated<br />
Retinal Detachments: A Multicenter Study. Ron<br />
A. Adelman 1 , A. Parnes 1 , D. Ducournau 2 . 1 Ophthal<br />
& Visual Science, Yale Univ Sch of Medicine, New<br />
Haven, CT; 2 Clinique Sourdille, Nantes, France<br />
4954 — 3:15 Primary Scleral Buckling:<br />
A Safe and Effective Treatment Option for<br />
Retinal Detachment. Frank Ruda 1 , A. Jirgis 2, 3 ,<br />
N. Jabbour 1, 2 . 1 West Virginia University Eye<br />
Institute, Morgantown, WV; 2 ForSight Foundation,<br />
Morgantown, WV; 3 National Eye Institute - Cairo,<br />
Cairo, Egypt<br />
4955 — 3:30 Quantifying the Effects of<br />
Enzymatic Vitreolysis Reveals Biomechanical<br />
Roles of Structural Macromolecules in Shear<br />
and Extension. Benjamen Filas, Q. Zhang, Y. Shui,<br />
D. C. Beebe. Ophthalmology and Visual Sciences,<br />
Washington University School of Medicine, St.<br />
Louis, MO *CR<br />
4956 — 3:45 Traditional versus Extreme<br />
Pneumatic Retinopexy. Darin R. Goldman, C. P.<br />
Shah, J. S. Heier. Retina, Ophthalmic Consultants<br />
of Boston, Boston, MA *CR<br />
4957 — 4:00 Pediatric Rhegmatogenous<br />
Retinal Detachment Surgery by Segmental<br />
Scleral Bucking: Risk Factors and Anatomical<br />
Outcomes. Sidath E. Liyanage, M. Errera, R.<br />
Moya, S. Wong, E. Ezra. Vitreoretinal Department,<br />
Moorfields Eye Hospital, London, United Kingdom<br />
4958 — 4:15 Prophylactic Treatments for<br />
Retinal Tears/Detachment in Stickler Syndrome:<br />
Single Institution Experience. Kiran Turaka, S.<br />
Bryan, A. J. Gordon, H. M. Kwong, C. H. Sell.<br />
Retina, Associated Retina Consultants Ltd, Phoenix,<br />
AZ<br />
<strong>Wednesday</strong> Papers<br />
Minisymposium<br />
2:45 pm – 4:30 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
319
4959 – 4974 – <strong>Wednesday</strong> – Papers/Minisymposium<br />
609<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Lens<br />
462 Lens Proteins/Physical Chemistry<br />
Moderators: Suraj P. Bhat and Jayanti Pande<br />
4959 — 2:45 Presence of αA-crystallin and<br />
αB-crystallin as two Independent Proteins in<br />
the Developing Ocular Lens: Evidence from<br />
Transmission Electron Microscopy. Rajendra K.<br />
Gangalum 1 , J. Horwitz 1 , S. A. Kohan 3 , I. Dighe 1 ,<br />
S. P. Bhat 1, 2 . 1 Ophthalmology, Jules Stein Eye<br />
Institute, UCLA, Los Angeles, CA; 2 Molecular<br />
Biology Institute @ UCLA, Los Angeles, CA;<br />
3<br />
Brain Research Insitute, Los Angeles, CA<br />
4965 — 4:15 Statistical-thermodynamic<br />
model for charge-regulation properties of<br />
bovine γB-crystallin. George M. Thurston 1 , M.<br />
Martini 1, 3 , C. W. Wahle 2 , D. Hollenbeck 1 , D. S.<br />
Ross 2 , J. F. Hamilton 2 . 1 Physics, Rochester Institute<br />
of Technology, Rochester, NY; 2 Mathematics,<br />
Rochester Institute of Technology, Rochester,<br />
NY; 3 Physics, University of Illinois at Urbana-<br />
Champaign, Urbana-Champaign, IL<br />
TCC LL 4/5<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Genetics<br />
464 Advances in Ocular Genetics<br />
Moderators: Janey L. Wiggs and Edwin M. Stone<br />
4971 — 2:45 Transgenic TBK1 mouse develops<br />
signs of normal tension glaucoma. John H.<br />
Fingert 1 , K. A. Miller 1 , F. Solivan-Timpe 1 , B. Roos 1 ,<br />
A. L. Robin 2 , R. F. Mullins 1 , M. G. Anderson 3 .<br />
1<br />
Ophthalmology, University of Iowa, Iowa City, IA;<br />
2<br />
Ophthalmology and International Health, Johns<br />
Hopkins University, Baltimore, MD; 3 Physiology,<br />
University of Iowa, Iowa City, IA *CR<br />
4972 — 3:00 Dominant-negative RBP4<br />
mutations cause congenital eye malformations<br />
through a maternal-fetal nutritional interaction.<br />
Tom M. Glaser 1, 2 , C. Chou 2 , S. A. Tarle 2 , J. Pribila 4 ,<br />
T. Bardakjian 5 , A. S. Schneider 5 , C. C. Nelson 3 , T.<br />
M. Glaser 1, 2 . 1 Cell Biology & Human Anatomy,<br />
Univ of California, Davis School of Medicine,<br />
Davis, CA; 2 Human Genetics, Univ Michigan, Ann<br />
Arbor, MI; 3 Ophthalmology, Univ Michigan, Ann<br />
Arbor, MI; 4 Pediatric Ophthalmology, Park Nicollet<br />
Hospital, Lincoln Park, MN; 5 Genetics, Albert<br />
Einstein Medical Center, Philadelphia, PA<br />
4973 — 3:15 Non-exomic and synonymous<br />
variants in ABCA4 are an important cause<br />
of Stargardt disease. Edwin M. Stone 1, 2 , B. A.<br />
Tucker 1 , T. A. Braun 1 , R. F. Mullins 1 , A. H. Wagner 1 ,<br />
S. G. Jacobson 3 , A. V. Cideciyan 3 , B. L. Lam 4 , G. A.<br />
Fishman 5 . 1 Department of Ophthalmology, Institute<br />
for Vision Research, University of Iowa, Iowa City,<br />
IA; 2 Howard Hughes Medical Institute, Iowa City,<br />
IA; 3 Department of Ophthalmology, Scheie Eye<br />
Institute, University of Pennsylvania, Philadelphia,<br />
PA; 4 Department of Ophthalmology, Bascom<br />
Palmer Eye Institute, University of Miami, Miami,<br />
FL; 5 Chicago Lighthouse for People Who Are Blind<br />
or Visually Impaired, Chicago, IL *CR<br />
4974 — 3:30 Application of Whole-Exome<br />
and Retinal-Capture Next-Generation DNA<br />
Sequencing to Identify Disease-Causing<br />
Mutations in Families with a Diagnosis of<br />
Autosomal Dominant Retinitis Pigmentosa.<br />
Stephen P. Daiger 1 , L. S. Sullivan 1 , S. J. Bowne 1 ,<br />
G. M. Weinstock 2 , D. C. Koboldt 2 , R. Chen 3 , J. R.<br />
Heckenlively 4 , K. E. Branham 4 , D. G. Birch 5 , D.<br />
K. Wheaton 5 . 1 Human Genetics Center, School of<br />
Public Health, The Univ. of Texas Health Science<br />
Center, Houston, TX; 2 The Genome Institute,<br />
Washington University, St. Louis, MO; 3 Dept. of<br />
Molecular and Human Genetics, Baylor College of<br />
Medicine, Houston, TX; 4 Kellogg Eye Center, Univ.<br />
of Michigan, Ann Arbor, MI; 5 Retina Foundation of<br />
the Southwest, Dallas, TX *CR<br />
<strong>Wednesday</strong> Papers/<br />
Minisymposium<br />
2:45 pm – 4:30 pm<br />
4960 — 3:00 Targeted disruption of lens<br />
αA-crystallin in Zebrafish (Danio Rerio).<br />
Hassane S. Mchaourab, P. Zou, W. Chen. Molec<br />
Physiol&Biophys-Med Ctr, Vanderbilt University,<br />
Nashville, TN<br />
4961 — 3:15 Surface-enhanced Raman<br />
spectroscopy (SERS) of gamma crystallins: A<br />
promising technique to study the redox reactions<br />
of cysteine residues in dilute protein solutions.<br />
Jayanti Pande 1 , J. A. Gomez-Santos 2, 1 , A. Pande 1 .<br />
1<br />
Department of Chemistry, University at Albany-<br />
SUNY, Albany, NY; 2 Department of Chemistry,<br />
Universidad Industrial de Santander, Bucaramanga,<br />
Colombia<br />
4962 — 3:30 Identification and Spatial<br />
Localization of Ocular Lens Age- and Cataract-<br />
Specific Protein Signatures. Kevin L. Schey 1, 2 ,<br />
K. M. Rose 1 , D. M. Anderson 1 . 1 Biochemistry,<br />
Vanderbilt University, Nashville, TN;<br />
2<br />
Ophthalmology and Visual Sciences, Vanderbilt<br />
University, Nashville, TN<br />
4963 — 3:45 Expression and Distribution<br />
of Thiol-Regulating Enzyme Glutaredoxin 2<br />
(Grx2) in Porcine Ocular Tissues. Xiaoli Tian 1 ,<br />
B. P. Upadhyaya 1 , H. Wu 1 , M. F. Lou 1, 2 . 1 School<br />
of Veterinary Medicine and Biomedical Sciences,<br />
University of Nebraska-Lincoln, Lincoln, NE;<br />
2<br />
Redox Biology Center, University of Nebraska<br />
Lincoln, Lincoln, NE<br />
4964 — 4:00 Expression of K6W-mutant<br />
ubiquitin in human lens epithelial cells (HLEC)<br />
alters conformation and linkages of polyubiquitin<br />
chains. Allen Taylor 1 , K. Liu 1 , M.<br />
Chang 1 , B. E. Riley 2 , T. A. Shaler 3 , K. M. Rose 4 ,<br />
K. L. Schey 4 , F. Shang 1 . 1 Nutrition &Vision Res-<br />
USDA-HNRCA, Tufts University, Boston, MA;<br />
2<br />
Elan Pharmaceuticals Inc, South San Francisco,<br />
CA; 3 Stanford Research Institute, Menlo Park, CA;<br />
4<br />
Mass Spectrometry Research Center, Vanderbilt<br />
University, Nashville, TN<br />
611-614<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Retinal Cell Biology<br />
463 Transplanted and Endogenous<br />
Cells as Effectors of Outer Retinal<br />
Repair - Minisymposium<br />
This Minisymposium will provide an overview of<br />
the emerging approaches for developing cell-based<br />
therapies to treat diseases of the outer retina.<br />
Moderators: David M. Gamm and<br />
Peter F. Hitchcock<br />
— 2:45 Introduction<br />
4966 — 2:50 Retinal Repair Following<br />
Transplantation of ES-Derived Photoreceptor<br />
Cells. Robin R. Ali. Div of Molecular Therapy,<br />
UCL Institute of Ophthalmology, London, United<br />
Kingdom<br />
4967 — 3:10 Directing the Adult RPE Stem<br />
Cell to Promote Retinal Repair. Sally Temple.<br />
Neural Stem Cell Institute, Rensselaer, NY *CR<br />
4968 — 3:30 Development of Cellular<br />
Therapies Using hESC-derived RPE. Dennis<br />
O. Clegg. Department of Molecular, Cellular and<br />
Developmental Biology, University of California<br />
Santa Barbara, Santa Barbara, CA *CR<br />
4969 — 3:50 The Production of Photoreceptors<br />
and RPE Cells from Adult Retinal Stem Cells.<br />
Derek Van Der Kooy. University of Toronto,<br />
Toronto, ON, Canada<br />
4970 — 4:10 Molecular Mechanisms<br />
Underlying Muller Glia Dedifferentiation and<br />
Proliferation During Regeneration Of The<br />
Damaged Zebra Fish Retina. David R. Hyde. Dept<br />
of Biological Sciences, University of Notre Dame,<br />
Notre Dame, IN<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
320
<strong>Wednesday</strong> – Papers/Minisymposium – 4975 – 4984<br />
4975 — 3:45 Rare and common variants in<br />
extracellular matrix gene fibrillin 2 (FBN2)<br />
are associated with inherited and age-related<br />
macular degeneration, respectively. Anand<br />
Swaroop 1 , R. Priya 1 , X. Zhan 2 , R. Fariss 1 , K. E.<br />
Branham 2 , E. Y. Chew 1 , D. Stambolian 4 , S. S.<br />
Bhattacharya 3 , J. R. Heckenlively 2 , G. Abecasis 2 .<br />
1<br />
N-NRL, Bldg 6, National Eye Institute,<br />
Bethesda, MD; 2 University of Michigan, Ann<br />
Arbor, MI; 3 Institute of Ophthalmology, London,<br />
United Kingdom; 4 University of Pennsylvania,<br />
Philadelphia, PA *CR<br />
4976 — 4:00 Exome sequencing in the midwestern<br />
Amish to identify rare variation<br />
influencing AMD. Jessica N. Cooke Bailey 1 , L.<br />
D’Aoust 1 , L. Jiang 1 , R. Laux 1 , A. Agarwal 1 , W.<br />
K. Scott 2 , M. A. Pericak-Vance 2 , J. L. Haines 1 .<br />
1<br />
Center for Human Genetics Research, Vanderbilt<br />
University Medical Center, Nashville, TN;<br />
2<br />
Hussman Institute of Human Genomics, Miller<br />
School of Medicine, University of Miami, Miami,<br />
FL *CR<br />
4977 — 4:15 Chipping Away At The Genetics<br />
of Age Related Macular Degeneration. Goncalo<br />
Abecasis 1 , M. C. Schu 3 , X. Zhan 1 , S. Arumugam 4 ,<br />
J. Bragg Gresham 1 , L. Fritsche 2 . 1 University of<br />
Michigan, Ann Arbor, MI; 2 Institute of Human<br />
Genetics, University of Regensburg, Regensburg,<br />
Germany; 3 Boston University School of Medicine,<br />
Boston, MA; 4 Case Western Reserve University,<br />
Cleveland, OH *CR<br />
TCC 305<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Eye Movements / Strabismus / Amblyopia /<br />
Neuro-Ophthalmology / Visual Psychophysics /<br />
Physiological Optics<br />
465 Amblyopia: Neural Mechanisms<br />
and Treatment<br />
Moderators: Eileen E. Birch and<br />
Benjamin Thompson<br />
4978 — 2:45 Retinal genes and proteins<br />
associated with postnatal visual deprivation in<br />
rats. Melissa Meyer zu Horste 1, 2 , V. Prokosch-<br />
Willing 3 , H. Melkonyan 3 , T. Stupp 3 , S. Thanos 3 .<br />
1<br />
Ophthalmology, University Hospital of Duisburg-<br />
Essen, Essen, Germany; 2 Ophthalmology,<br />
Angiogenesis Laboratory, Massachusetts Eye and<br />
Ear Infirmary, Cambridge, MA; 3 Experimental<br />
Ophthalmology, School of Medicine, Westfalian-<br />
Wilhelms-University Muenster, Muenster, Germany<br />
4979 — 3:00 Concordance with occlusion<br />
therapy for childhood amblyopia. Michael P.<br />
Wallace 1 , C. E. Stewart 1 , M. J. Moseley 1 , D. A.<br />
Stephens 2 , A. R. Fielder 1 . 1 Optometry and Visual<br />
Science, City University, London, United Kingdom;<br />
2<br />
Mathematics and Statistics, McGill University,<br />
Montreal, QC, Canada f<br />
4980 — 3:15 Patching therapy for amblyopia,<br />
are we patching the wrong eye? Jiawei Zhou 1 , B.<br />
Thompson 2 , R. F. Hess 1 . 1 Ophthalmology, McGill<br />
University, Montreal, QC, Canada; 2 Optometry and<br />
Vision Science, University of Auckland, Auckland,<br />
New Zealand *CR<br />
4981 — 3:30 Binocular iPad Treatment<br />
for Amblyopia. Simone Li 1 , V. Subramanian 1 ,<br />
L. To 2 , R. M. Jost 1 , S. Jost 1 , D. R. Stager 3 , L.<br />
Dao 4 , D. R. Stager 4 , E. E. Birch 1, 5 . 1 Pediatrics,<br />
Retina Foudation of the Southwest, Dallas, TX;<br />
2<br />
Schepens Eye Research Institute, Boston, MA;<br />
3<br />
Pediatric Ophthalmology and the Center for Adult<br />
Strabismus, Dallas, TX; 4 Pediatric Ophthalmology<br />
and Adult Strabismus, Plano, TX; 5 Ophthalmology,<br />
University of Texas Southwestern Medical Center,<br />
Dallas, TX *CR<br />
4982 — 3:45 Dichoptic perceptual learning<br />
induces visual cortex plasticity in adults<br />
with amblyopia. Jinrong Li 1, 2 , B. Thompson 3 ,<br />
D. Deng 2 , L. Y. Chan 4 , M. Yu 1, 2 , R. F. Hess 5 .<br />
1<br />
Department of Optometry and Vision Science,<br />
Sun Yat-sen University, Guangzhou, China; 2 State<br />
Key Laboratory of Ophthalmology, Zhongshan<br />
Ophthalmic Center, Sun Yat-sen University,<br />
Guangzhou, China; 3 Optometry and Vision Science,<br />
University of Auckland, Auckland, New Zealand;<br />
4<br />
The Hong Kong Polytechnic University, The Hong<br />
Kong Polytechnic University, Hong Kong, China;<br />
5<br />
Department of Ophthalmology, McGill University,<br />
Montreal, QC, Canada *CR<br />
4983 — 4:00 Anodal tDCS Enhances the Effect<br />
of Binocular Therapy on Stereopsis in Adults<br />
with Amblyopia. Daniel P. Spiegel 1 , J. LI 2 , R. F.<br />
Hess 3 , W. D. Byblow 4 , L. To 5 , J. R. Cooperstock 6 ,<br />
M. Yu 2 , B. Thompson 1 . 1 Department of Optometry<br />
and Vision Science, The University of Auckland,<br />
Auckland, New Zealand; 2 State Key Laboratory of<br />
Ophthalmology, Zhongshan Ophthalmic Center,<br />
Sun Yat-sen University, Guangzhou, China;<br />
3<br />
Department of Ophthalmology, McGill University,<br />
Montreal, QC, Canada; 4 Department of Sport and<br />
Exercise Science, The University of Auckland,<br />
Auckland, New Zealand; 5 Schepens Eye Research<br />
Institute, Boston, MA; 6 Department of Electrical<br />
and Computer Engineering, McGill University,<br />
Montreal, QC, Canada *CR<br />
4984 — 4:15 Attention deficits in human<br />
strabismic amblyopia measured via neural<br />
responses to texture-defined forms: A highdensity<br />
EEG mapping study. Chuan Hou 1 , A.<br />
Norcia 2 , P. Verghese 1 , S. P. McKee 1 . 1 The Smith-<br />
Kettlewell Eye Research Institute, San Francisco,<br />
CA; 2 Stanford University, Stanford, CA<br />
<strong>Wednesday</strong> Papers<br />
Minisymposium<br />
2:45 pm – 4:30 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
321
4985 – 5004 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
Exhibit Hall A0114-A0145<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Biochemistry/Molecular Biology<br />
466 AMD II, BI<br />
Moderator: Alecia K. Gross<br />
4985 — A0114 Comparison of the Gene<br />
Expression by Haplogroups H and J:<br />
Implications for AMD (Age Related Macular<br />
Degeneration). Claudio A. Ramirez 1 , M. Chwa 1 ,<br />
S. Atilano 1 , D. Malik 1 , J. Cáceres del Carpio 1 ,<br />
M. Tarek 1 , S. Jazwinski 2 , M. V. Michael 2 , B. D.<br />
Kuppermann 1 , C. M. Kenney 1 . 1 Gavin Herbert Eye<br />
Institute, University of California, Irvine, Irvine,<br />
CA; 2 Tulane Center for Aging, Tulane University,<br />
New Orleans, LA *CR<br />
4986 — A0115 Hops Extract Xanthohumol<br />
Protects Visual Acuity and Function After Light<br />
Damage. Stephanie L. Foster, N. F. Henneman,<br />
M. A. Chrenek, C. B. Wright, J. H. Boatright.<br />
Ophthalmology, Emory Univ School of Med,<br />
Atlanta, GA<br />
4987 — A0116 Role of Apoptotic Regulatory<br />
Proteins in Retinoblastoma. Lata Singh 1 , S.<br />
Kashyap 1 , N. Pushker 2 , S. Sen 1 , S. Bakhshi 3 , A.<br />
Sharma 4 , N. Saini 5 , J. Kaur 6 . 1 Ocular Pathology,<br />
All India Institute of Medical Sciences, New<br />
Delhi, India; 2 Ophthalmology, All India Institute<br />
of Medical Sciences, New Delhi, India; 3 Medical<br />
Oncology, IRCH, All India Institute of Medical<br />
Sciences, New Delhi, India; 4 Ocular Microbiology,<br />
All India Institute of Medical Sciences, New Delhi,<br />
India; 5 Biochemistry, Institute of Genomics and<br />
Integrative Biology, Mall Road, New Delhi, India;<br />
6<br />
Ocular Biochemistry, All India Institute of Medical<br />
Sciences, New Delhi, India<br />
4988 — A0117 Comparison Study of IL-33<br />
Gene Expression in Haplogroup H, J, L, and K<br />
Cybrids. Thomas A. Vo 1 , M. Chwa 1 , S. Atilano 1 ,<br />
D. Malik 1 , C. A. Ramirez 1 , J. Cáceres del Carpio 1 ,<br />
S. Jazwinski 2 , M. V. Michael 2 , B. D. Kuppermann 1 ,<br />
C. M. Kenney 1 . 1 Opthalmology, Gavin Herbert Eye<br />
Institute at UC Irvine, Irvine, CA; 2 Tulane Center<br />
for Aging at Tulane University, New Orleans, LA<br />
*CR<br />
4989 — A0118 Resveratrol Protects<br />
Human Retinal Pigment Epithelial Cells<br />
from Inflammatory Insults. R K. Kutty 1 ,<br />
C. N. Nagineni 1 , W. Samuel 1 , T. Duncan 1 , C.<br />
Vijayasarathy 2 , C. Jaworski 1 , T. Redmond 1 .<br />
1<br />
National Eye Institute, National Institutes of<br />
Health, Bethesda, MD; 2 National Institute on<br />
Deafness and Other Communication Disorders,<br />
National Institutes of Health, Bethesda, MD<br />
4990 — A0119 Bone morphogenetic protein<br />
4 induces ID1 and ID3 transcription factors in<br />
trabecular meshwork cells. Avani A. Mody, R.<br />
J. Wordinger, A. F. Clark. Visual sicence /NTERI,<br />
UNTHSC, Fort Worth, TX *CR<br />
4991 — A0120 The proteolytic activity of<br />
HTRA1 is responsible for its pathological role<br />
in polypoidal choroidal vasculopathy. Sandeep<br />
Kumar 1, 2 , A. Jones 1, 2 , Z. Berriochoa 2 , S. Wang 2 , Y.<br />
Fu 1, 2 . 1 Moran Center for Translational Medicine,<br />
University of Utah, Salt Lake City, UT; 2 Dept of<br />
Ophthalmology and Visual Sciences, University of<br />
Utah, Salt Lake City, UT *CR<br />
4992 — A0121 Associations between Posterior<br />
Vitreous Detachment and Concentrations of<br />
Various Cytokines in Eyes with Age-related<br />
Macular Degeneration and Normal Control<br />
Eyes. Hidenori Takahashi 1 , X. Tan 2 , Y. Nomura 2 ,<br />
A. Iriyama 2 , Y. Fujino 3 , Y. Okubo 1 , A. Sato 1 ,<br />
M. Takezawa 1 , H. Kawashima 1 , Y. Yanagi 2 .<br />
1<br />
Ophthalmology, Jichi Medical University,<br />
Shimotsuke-shi, Japan; 2 Ophthalmology, University<br />
of Tokyo, Tokyo, Japan; 3 Ophthalmology, Tokyo<br />
KoseiNenkin Hospital, Tokyo, Japan<br />
4993 — A0122 Quantitative Proteomic<br />
Identification of Novel Interacting Partners<br />
for the Serine Protease Htra1. Lili Feng 1 , E.<br />
Kortvely 1 , A. Vogt 1 , K. Boldt 1 , M. Ueffing 1, 2 . 1 Center<br />
of Ophthalmology, University of Tuebingen,<br />
Tuebingen, Germany; 2 Research Unit for Protein<br />
Science, Helmholtz Zentrum München, Neuherberg,<br />
Germany<br />
4994 — A0123 Amyloid Beta 1- 42 Promotes<br />
NLRP3-inflammasome Activation In Retinal<br />
Pigmented Epithelial Cells. Matthew West 1 ,<br />
F. Lamoke 1 , A. Montemari 2 , G. Parisi 3 , G.<br />
Ripandelli 3 , D. M. Marcus 4 , M. Bartoli 1 .<br />
1<br />
Department of Ophthalmology, Georgia Health<br />
Sciences University, Augusta, GA; 2 Department of<br />
Experimental Medicine and Pathology, University<br />
of Rome, Rome, Italy; 3 IRCCS Fondazione GB<br />
Bietti, Rome, Italy; 4 Southeast Retina Center,<br />
Augusta, GA *CR<br />
4995 — A0124 Conditional ablation of<br />
VEGFR-1 in photoreceptors induces retinal<br />
angiomatous proliferation: A transgenic mouse<br />
model of AMD. Ling Luo 1, 2 , X. Zhang 1 , S. K. Das 1 ,<br />
H. Uehara 1 , T. Miya 1 , T. Olsen 1 , B. Archer 1 , Y.<br />
Fu 1 , W. Baehr 1 , B. K. Ambati 1 . 1 Moran eye center,<br />
University of Utah, Salt lake city, UT; 2 Department<br />
of Ophthalmology, The 306th hospital of PLA,<br />
China, Beijing, China *CR<br />
4996 — A0125 In-depth analysis of blood<br />
plasma proteome for discovery of age-related<br />
macular degeneration biomarkers. Se Joon<br />
Woo 1, 2 , H. Kim 3 , E. Suh 3 , J. Park 1, 2 , J. Ahn 1, 2 ,<br />
D. Hwang 1, 2 , J. Lee 3 , K. Park 1, 2 , C. Lee 3, 4 .<br />
1<br />
Ophthalmology, Seoul National University<br />
College of Medicine, Seoul, Republic of Korea;<br />
2<br />
Ophthalmology, Seoul National University<br />
Bundang Hospital, Seongnam, Republic of Korea;<br />
3<br />
Theragnosis Research Center, Korea Institute of<br />
Science and Technology, Seoul, Republic of Korea;<br />
4<br />
Biomolecular Science, University of Science and<br />
Technology, Daejeon, Republic of Korea<br />
4997 — A0126 Post-Transcriptional Gene<br />
Interactions in Retinal Ischemia. Kalina<br />
Andreeva, M. Soliman, N. G. Cooper. Anatomical<br />
Sciences & Neurobiology, University of Louisville<br />
School of Medicine, Louisville, KY<br />
4998 — A0127 An In-Vitro Study of Wnt<br />
Pathway Modulation in Cybrid H and J<br />
Mitochondrial Haplogroups and the Possible<br />
Implications for Age-related Macular<br />
Degeneration. Payam Falatoonzadeh 1 , G. B. Woo 1 ,<br />
N. Udar 1 , S. Atilano 1 , M. Chwa 1 , M. V. Michael 2 , S.<br />
Jazwinski 2 , C. M. Kenney 1 . 1 Ophthalmology, Gavin<br />
Herbert Eye Inst., UC Irvine, Irvine, CA; 2 Tulane<br />
Center for Aging, Tulane University, New Orleans,<br />
LA *CR<br />
4999 — A0128 Expression of VEGF-C,<br />
VEGF-D and their Cognate Receptors in<br />
Experimental Choroidal Neovascularization<br />
and Clinical AMD. Kameran Lashkari 1 , J. Ma 1 ,<br />
G. Teague 1 , J. G. Arroyo 2 . 1 Schepens Eye Research<br />
Institute/ Massachusetts Eye & Ear, Harvard Med<br />
School, Boston, MA; 2 Beth Israel Deaconess<br />
Medical Center, Harvard Med School, Boston, MA<br />
*CR<br />
5000 — A0129 Mitochondrial DNA<br />
Damage Increases with Age-related Macular<br />
Degeneration in the RPE but not Neural<br />
Retina. Marcia R. Terluk 1 , L. M. Soukup 2 , S. R.<br />
Montezuma 1 , D. A. Ferrington 1 . 1 Ophthalmology<br />
and Visual Neurosciences, University of Minnesota,<br />
Minneapolis, MN; 2 Biology, University of St.<br />
Thomas, St. Paul, MN<br />
5001 — A0130 Oxidative Stress-Induced<br />
Necrosis in RPE Cells. Jakub Hanus 1 , W. C.<br />
Anderson 1 , P. Jin 3 , Q. Liu 4 , S. Wang 1, 2 . 1 Cell<br />
and Molecular Biology, Tulane University, New<br />
Orleans, LA; 2 Ophthalmology, Tulane University,<br />
New Orleans, LA; 3 Human Genetics, Emory<br />
University, Atlanta, GA; 4 Biochemistry, University<br />
of Texas Southwestern Medical Center, Dallas, TX<br />
*CR<br />
5002 — A0131 Phosphorylation Networks in<br />
Age-Related Macular Degeneration. Srinivas R.<br />
Sripathi 1 , O. Sylvester 2 , T. Moser 1 , P. S. Bernstein 3 ,<br />
F. Lamoke 4 , M. Bartoli 4 , W. Jahng 2 . 1 Biological<br />
Sciences, Michigan Tech University, Houghton,<br />
MI; 2 Retina Proteomics Laboratory, Petroleum<br />
Chemistry, American University of Nigeria, Yola,<br />
Nigeria; 3 Ophthalmology and Visual Sciences,<br />
Moran Eye Center, University of Utah, Salt Lake<br />
City, UT; 4 Ophthalmology, Georgia Health Sciences<br />
University, Augusta, GA *CR<br />
5003 — A0132 Evaluation of RPE cell<br />
senescence as a mechanism for age-related<br />
macular degeneration (AMD),. Michael R.<br />
Kozlowski. Arizona College of Optometry,<br />
Midwestern University, Glendale, AZ<br />
5004 — A0133 An In-Vitro Study of the Effect<br />
of Ultraviolet Radiation on Growth Patterns and<br />
Gene Expression of Human ARPE-19 Cybrid H<br />
and J, and their Implications with Age-related<br />
Macular Degeneration (AMD). Deepika Malik 1 ,<br />
P. Falatoonzadeh 1 , T. Hsu 1, 2 , C. A. Ramirez 1 , J.<br />
Cáceres del Carpio 1 , M. Mohamed Moustafa 1 , S.<br />
Jazwinski 3 , M. V. Michael 3 , C. M. Kenney 1 , B. D.<br />
Kuppermann 1 . 1 Ophthalmology, Gavin Herbert<br />
Eye Institute, Irvine, CA; 2 Warren Alpert Medical<br />
School, Brown University, Providence, RI; 3 Tulane<br />
Center for Aging, Tulane University, New Orleans,<br />
LA *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
322
<strong>Wednesday</strong> – Posters – 5005 – 5027<br />
5005 — A0134 Cybrids with Different mtDNA<br />
Haplogroups Show Differential Expression of<br />
Respiratory Complex Genes. Cristina M. Kenney 1 ,<br />
M. Chwa 1 , S. Atilano 1 , P. Falatoonzadeh 1 , D. Malik 1 ,<br />
C. A. Ramirez 1 , S. Jazwinski 2 , M. V. Michael 2 , B.<br />
D. Kuppermann 1 . 1 Ophthalmology, Gavin Herbert<br />
Eye Inst, UC Irvine, Irvine, CA; 2 Tulane Center for<br />
Aging, Tulane University, New Orleans, LA *CR<br />
5006 — A0135 The serine protease HTRA1<br />
is a potential regulator of the inflammatory<br />
cytokine GDF15. Chloe M. Stanton 1 , E. Kortvely 2 ,<br />
C. Hayward 1 , M. Ueffing 2, 3 , A. F. Wright 1 . 1 MRC<br />
Human Genetics Unit, MRC IGMM, University<br />
of Edinburgh, Edinburgh, United Kingdom;<br />
2<br />
Centre for Ophthalmology, Institute for Opthalmic<br />
Research Tubingen, Tubingen, Germany; 3 Research<br />
Unit of Protein Science, Helmholtz Zentrum<br />
Munchen, Munich, Germany<br />
5007 — A0136 Role of complement in altered<br />
RPE function and deposit formation in Efemp1<br />
mutant mice: A primary cell culture model.<br />
Rosario Fernandez-Godino, E. A. Pierce, D.<br />
Garland. Ophthalmology, Ocular Genomics<br />
Institute. Mass Eye and Ear Infirmary. Harvard<br />
Medical School, Boston, MA<br />
5008 — A0137 Quantifying progression of<br />
disease in aging mouse and human RPE. John<br />
M. Nickerson 1 , X. Qi 2 , T. Jiang 3 , Y. Cheng 3 , J. M.<br />
Zhang 3 , M. A. Chrenek 1 , A. Rashid 1 , S. K. Arora 1 , H.<br />
E. Grossniklaus 1 , Y. Jiang 2 . 1 Ophthalmology, Emory<br />
Univ, Atlanta, GA; 2 Mathematics, Georgia State<br />
University, Atlanta, GA; 3 Statistics, Yale University,<br />
New Haven, CT<br />
5009 — A0138 Zinc Staining of sub-<br />
RPE Deposits in Murine Models of Retinal<br />
Degeneration. Rebecca J. Kapphahn 1 , H.<br />
Roehrich 2 , D. A. Ferrington 1 , F. J. van Kuijk 1 .<br />
1<br />
Ophthalmology, University of Minnesota,<br />
Minneapolis, MN; 2 Histology Core for Vision<br />
Research, Universtiy of Minnesota, Minneapolis,<br />
MN<br />
5010 — A0139 VEGF, VEGF-C, and VEGF-D<br />
Increases in Aqueous Humor Samples in a LPS<br />
Induced Model of Uveitis in New Zealand White<br />
Rabbits. Douglas Decker, J. E. Burr, K. Lester, V.<br />
Zaworski, S. J. Weber. Biochemistry, PharmOptima,<br />
Portage, MI *CR<br />
5011 — A0140 The role of Cannabinoid<br />
receptors on light-induced photoreceptor<br />
degeneration. Tomoyo Imamura, Y. Ohno,<br />
K. Tsuruma, M. Shimazawa, H. Hara. Gifu<br />
Pharmaceutical University, Gifu, Japan<br />
5012 — A0141 The involvement of heparinbinding<br />
epidermal growth factor like growth<br />
factor on light-induced retinal degeneration.<br />
Yuki Inoue, T. Nakanishi, A. Oyagi, Y. Ohno, T.<br />
Otsuka, K. Tsuruma, M. Shimazawa, H. Hara. Gifu<br />
Pharmaceutical University, Gifu, Japan<br />
5013 — A0142 Comparison Study of EFEMP1<br />
Gene Expression Levels in Human ARPE-19<br />
Cybrid Models Having Mitochondrial DNA<br />
of Haplogroups H, J, K or L. Danli Xing 1 , D.<br />
Malik 1 , P. Falatoonzadeh 1 , S. Atilano 1 , M. Chwa 1 ,<br />
S. Jazwinski 2 , M. V. Michael 2 , B. D. Kuppermann 1 ,<br />
C. M. Kenney 1 . 1 Ophthalmology, UC Irvine, Long<br />
Beach, CA; 2 Tulane Center for Aging, Tulane<br />
University, New Orleans, LA *CR<br />
5014 — A0143 Inositol phosphatase INPP5E<br />
in primary cilia and eye development. Na Luo 1 ,<br />
M. Conwell 1 , A. Kumar 1 , R. M. Anderson 2 , Y. Sun 1 .<br />
1<br />
Ophthalmology, Indiana University, Indianapolis,<br />
IN; 2 Pediatrics/Endocrinology, Indiana University,<br />
Indianapolis, IN *CR<br />
5015 — A0144 Human Complement Factor<br />
H (CFH) Transgene Expression Rescues the<br />
Visual Function and Retina Abnormalities in<br />
Aged cfh-/- Mice. Jindong Ding 1 , U. L. Kelly 1 , M.<br />
Groelle 1 , C. Bowes Rickman 1, 2 . 1 Ophthalmology,<br />
Duke University Medical Center, Durham, NC;<br />
2<br />
Cell Biology, Duke University Medical Center,<br />
Durham, NC<br />
5016 — A0145 Casein Kinase 1 Epsilon Is<br />
Identified As A Potential Therapuetic Target For<br />
Dry AMD By A Multi-Pronged Gene Expression<br />
Approach. George Inana 1 , C. Murat 1 , M. J.<br />
McLaren 2 . 1 Ophthalmology, Bascom Palmer Eye<br />
Institute, Miami, FL; 2 Graymatter Research, Miami,<br />
FL *CR<br />
Exhibit Hall A0179-A0204<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Visual Psychophysics / Physiological Optics<br />
467 Visual Functions in AMD<br />
Moderator: Michael D. Crossland<br />
5017 — A0179 Preliminary assessment of a<br />
new device to test potential visual acuity when<br />
compared to gold standard PAM. Elizabeth R.<br />
Richter, J. A. Kylstra. Storm Eye Institute, Medical<br />
University of South Carolina, Charleston, SC *CR,<br />
f<br />
5018 — A0180 Evaluation of vision autotesting<br />
in patients with AMD using an iPad App.<br />
Matthias G. Hartmann. Private Practice, Berlin,<br />
Germany *CR<br />
5019 — A0181 A New Contour Integration<br />
Macular Perimetry (CIMP) on iPad for Visual<br />
Function Evaluation in Maculopathy. Yi-Zhong<br />
Wang 1, 2 , G. Mitzel 1 . 1 Retina Foundation of the<br />
Southwest, Dallas, TX; 2 Ophthalmology, UT<br />
Southwestern Medical Center, Dallas, TX *CR<br />
5020 — A0182 myVisionTrack (mVT), a novel<br />
remote visual self-assessment, correlates with<br />
clinical course of macular function. Yu-Guang<br />
He 1 , J. D. Warminski 1 , Y. Wang 2 . 1 Ophthalmology,<br />
Univ Texas Southwestern Med Ctr, Dallas, TX;<br />
2<br />
Retina Foundation of the Southwest, Dallas, TX<br />
*CR<br />
5021 — A0183 Visual Acuity Loss In<br />
Patients With AMD, Measured Using A<br />
Vanishing Optotype Letter Chart. Nilpa<br />
Shah 1 , R. S. Anderson 1, 2 , A. Tufail 1 , C. A. Egan 1 ,<br />
S. Dakin 1 . 1 NIHR Biomedical Research Centre<br />
for Ophthalmology, Moorfields Eye Hospital &<br />
UCL Institute of Ophthalmology, London, United<br />
Kingdom; 2 Vision Science Research Group, School<br />
of Biomedical Sciences, University of Ulster at<br />
Coleraine, Northern Ireland, United Kingdom *CR<br />
5022 — A0184 Screening for AMD Using<br />
Psychophysical Correlates of Macular<br />
Dysfunction. Han Li 1 , S. M. Culican 2 . 1 Washington<br />
University School of Medicine, St. Louis, MO;<br />
2<br />
Dept of Ophthalmology and Visual Science,<br />
Washington University School of Medicine, St.<br />
Louis, MO<br />
5023 — A0185 A New Method to Depict<br />
Central Scotomas: Automated Sterocampimetry.<br />
Anthony P. Cappo 1 , R. B. Rosen 2 , W. H. Seiple 3 , M.<br />
D. Orr 1 , M. Arthurs 4 , T. Emborgo 5 . 1 Opticology,<br />
Inc., New York, NY; 2 New York Eye & Ear<br />
Infirmary, New York, NY; 3 Lighthouse International,<br />
New York, NY; 4 Universite de Montreal, Montreal,<br />
QC, Canada; 5 Hunter College, City University of<br />
New York, New York, NY *CR<br />
5024 — A0186 Spaeth/Richman Contrast<br />
Sensitivity Test in Macular Degeneration. Bruno<br />
M. Faria, F. Duman, M. Ali, C. Zangalli, S. S.<br />
Wizov, L. Lu, J. Richman, E. Spaeth, G. L. Spaeth.<br />
Glaucoma, Bruno Faria, Philadelphia, PA *CR, f<br />
5025 — A0187 Central And Paracentral<br />
Single-Letter Recognition In Eyes With Macular<br />
Lesions. Gianfrancesco M. Villani 1 , L. Bertelli 1 ,<br />
G. Sato 2 , M. U. Morales 3 , A. Colenbrander 4 .<br />
1<br />
Ophthalmology, Centro Riabilitazione Ipovedenti e<br />
Microperimetria - CRIM, Castel d’Azzano, Verona,<br />
Italy; 2 UO Oftalmologia, Centro Riabilitazione<br />
Visiva, Ospedale S. Antonio, Ulss16, Padova, Italy;<br />
3<br />
Ophthalmology and Visual Sciences, School of<br />
Clinical Sciences, The University of Nottingham,<br />
Nottingham, United Kingdom; 4 Smith-Kettlewell<br />
Eye Research Institute, San Francisco, CA *CR<br />
5026 — A0188 Longitudinal Changes in Retinal<br />
Sensitivity among Patients with Maculopathy.<br />
Hongting Liu, M. G. Bittencourt, O. O. Agbedia, A.<br />
Moradi, Y. J. Sepah, D. A. Ferraz, M. A. Ibrahim,<br />
R. Sophie, M. Ansari, Q. Nguyen. Retinal Imaging<br />
Research and Reading Center, Wilmer Eye Institute<br />
Johns Hopkins University, Baltimore, MD *CR<br />
5027 — A0189 Monitoring the Progression<br />
of AMD post anti-VEGF treatment using the<br />
OPKO OCT/SLO. michele arthurs 1 , R. B. Rosen 3 ,<br />
G. Landa 3 , R. Weitz 3 , W. H. Seiple 2, 3 . 1 Université<br />
de Montréal, Montréal, QC, Canada; 2 New York<br />
Lighthouse, New York, NY; 3 New York Eye & Ear<br />
Infirmary, New York, NY *CR, f<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
323
5028 – 5049 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
5028 — A0190 Relationship between<br />
Visual Function and Optical Coherence<br />
Tomography features in Early Age-related<br />
macular degeneration (AMD)-Early Markers<br />
Observational Study. Ruth E. Hogg 1 , G. Murphy 1 ,<br />
G. Staurenghi 2 , C. Rosina 2 , R. Silva 3 , A. Santos 3 ,<br />
U. Chakravarthy 1 . 1 Center for Vision and Vascular<br />
Science, Queen’s University Belfast, Belfast, United<br />
Kingdom; 2 Eye Clinic - Department of Clinical<br />
Science, “Luigi Sacco”- Sacco Hospital, II School<br />
of Ophthalmology - University of Milan, Milan,<br />
Italy; 3 Faculty of Medicine., University of Coimbra,<br />
Coimbra, Portugal *CR<br />
5029 — A0191 Relationship between retinal<br />
sensitivity and retinal thickness in eyes with<br />
retinal disease. Srinivas R. Sadda, M. Nittala.<br />
Ophthalmology, Doheny Eye Institute - USC, Los<br />
Angeles, CA *CR<br />
5030 — A0192 Multimodal Evaluation of<br />
Macular Function in Age-related Macular<br />
Degeneration. Ken Ogino, A. Tsujikawa, K.<br />
Yamashiro, S. Ooto, A. Oishi, I. Nakata, M. Miyake,<br />
A. Takahashi, A. A. Ellabban, N. Yoshimura. Kyoto<br />
University Graduate School of Medicine, Kyoto,<br />
Japan *CR<br />
5031 — A0193 The functional impact of<br />
subfoveal SD-OCT characteristic on reading<br />
acuity in neovascular age related macular<br />
degeneration. Florian Sulzbacher 1 , C. G. Kiss 1 , S.<br />
Sacu 1 , M. R. Munk 1 , A. Kaider 2 , T. Mittermueller 1 , P.<br />
K. Roberts 1 , U. Schmidt-Erfurth 1 . 1 Ophthalmology,<br />
Medical University Vienna, Vienna, Austria; 2 Center<br />
for Medical Statistics, Informatics, and Intelligent<br />
Systems; Section for Clinical Biometrics;, Medical<br />
University of Vienna, Vienna, Austria *CR<br />
5032 — A0194 Dark-adapted Microperimetry<br />
In Age-related Maculopathy And Geographic<br />
Atrophy. Michael D. Crossland 1, 2 , R. Ba-Abbad 1, 2 ,<br />
S. Degli Esposti 2 , A. Tufail 2, 3 , G. S. Rubin 1, 3 .<br />
1<br />
UCL Institute of Ophthalmology, London,<br />
United Kingdom; 2 Moorfields Eye Hospital NHS<br />
Foundation Trust, London, United Kingdom;<br />
3<br />
NIHR Moorfields Biomedical Research Centre for<br />
Ophthalmology, London, United Kingdom *CR<br />
5033 — A0195 Development of a Dark<br />
Adaptation Protocol for Use in AMD Clinical<br />
Trials. Gregory R. Jackson 1 , J. G. Edwards 2 .<br />
1<br />
Ophthalmology, Penn State College of Medicine,<br />
Hershey, PA; 2 MacuLogix, Hershey, PA *CR<br />
5034 — A0196 High Angular Resolution<br />
Peripheral Refraction in Patients with Age<br />
Related Macular Degeneration. Bart Jaeken 2, 1 ,<br />
E. Alcón 1, 3 , J. Marín 3 , P. Artal 1 . 1 Laboratorio de<br />
Optica, Universidad de Murcia, Murcia, Spain;<br />
2<br />
R&D, Voptica, Murcia, Spain; 3 Oftalmología,<br />
Hospital Virgen de la Arrixaca, Murcia, Spain *CR<br />
5035 — A0197 Compensation of fixational<br />
instability by the NIDEK MP-1 micro-perimeter.<br />
Arunkumar Krishnan, H. E. Bedell. University of<br />
Houston - College of Optometry, Houston, TX<br />
5036 — A0198 BCEA evaluation after pattern<br />
stimulation in wet AMD patients. Enzo M.<br />
Vingolo, P. G. Limoli, S. Fragiotta, V. De Rosa, D.<br />
Domanico. UOC Ophthal Hosp “SM Goretti” LT,<br />
University La Sapienza of Rome, Roma, Italy<br />
5037 — A0199 The Influence of Fixation<br />
Stability on Balance in Patients with a Central<br />
Scotoma. Caitlin Murphy 1, 4 , J. Chu 2 , E. Landy 2 ,<br />
J. Campbell 2 , A. Phan 2 , O. Overbury 1, 3 . 1 School<br />
of Optometry, University of Montreal, Montreal,<br />
QC, Canada; 2 Physiotherapy, McGill University,<br />
Montreal, QC, Canada; 3 Ophthalmology, McGill<br />
University, Montreal, QC, Canada; 4 Centre for<br />
Interdisciplinary Research in Rehabilitation (CRIR),<br />
Montreal, QC, Canada<br />
5038 — A0200 Impact of Visual Motion<br />
Displayed in a Non-Immersive Head-Mounted<br />
Device on the Balance of Patients with Age-<br />
Related Macular Degeneration. Caroline<br />
Chauvire 1 , C. Cecilia 1 , A. Koustanai 1 , J. Le Brun 1 ,<br />
S. Pineau 1 , T. Villette 2 , P. Chaumet-Riffaud 1, 3 ,<br />
S. Mohand-Said 1 , J. A. Sahel 1 , A. B. Safran 1 .<br />
1<br />
INSERM, U968; UPMC Univ Paris 06, UMR_S<br />
968, Institut de la Vision; CNRS, UMR_7210;<br />
CHNO des Quinze-Vingts, INSERM-DHOS CIC<br />
503, Paris, France; 2 Essilor R&D International,<br />
Paris, France; 3 Univ Paris Sud, AP-HP, CHU<br />
Bicêtre, Paris, France *CR<br />
5039 — A0201 Comparing the fixational and<br />
functional preferred retinal locus. Brian Sullivan,<br />
L. Renninger. Smith-Kettlewell Eye Research<br />
Institute, San Francisco, CA<br />
5040 — A0202 Maximum Reading Speed and<br />
Binocular Summation in Patients with Central<br />
Vision Loss. Luminita Tarita-Nistor 1, 2 , E. G.<br />
Gonzalez 1, 2 , M. H. Brent 3, 4 , S. N. Markowitz 3, 4 , M.<br />
J. Steinbach 1, 2 . 1 Vision Science Research Program,<br />
Toronto Western Hospital, Toronto, ON, Canada;<br />
2<br />
Centre for Vision Research, York University,<br />
Toronto, ON, Canada; 3 Ophthalmology and<br />
Vision Sciences, University of Toronto, Toronto,<br />
ON, Canada; 4 Ophthalmology, Toronto Western<br />
Hospital, Toronto, ON, Canada<br />
5041 — A0203 Predictive Factors of Reading<br />
Performance Post Reading Rehabilitation<br />
Program in Central Field Loss Patients.<br />
Salvatore Di Lauro, M. B. Coco, A. López-Miguel,<br />
R. Cuadrado, A. Mayo, J. De Lázaro, M. J.<br />
Maldonado, J. Herrera, L. Mena, J. Pastor. Retina-<br />
Low Vision, IOBA Eye Institute, University of<br />
Valladolid, Valladolid, Spain *CR<br />
5042 — A0204 Do Pedestrians Make Safe<br />
Street-Crossing Decisions? Shirin E. Hassan.<br />
School of Optometry, Indiana University,<br />
Bloomington, IN<br />
Exhibit Hall B0001-B0033<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Physiology/Pharmacology<br />
468 Drug Delivery III<br />
Moderators: Ashim K. Mitra and<br />
Uday B. Kompella<br />
5043 — B0001 A minimally invasive and<br />
localised intra-scleral delivery of drug-loaded<br />
thermoresponsive polymeric implants to treat<br />
posterior ocular diseases. Hannah L. McMillan,<br />
S. J. Fallows, T. R. Singh, D. S. Jones. School of<br />
Pharmacy, Queen’s University Belfast, Belfast,<br />
United Kingdom *CR<br />
5044 — B0002 Hindered convective transport<br />
of nanoparticles and macromolecules in<br />
the vitreous humor. Anita N. Penkova 1, 2 , K.<br />
Rattanakijsuntorn 1 , Y. Tang 2 , R. Moats 2, 3 , M. R.<br />
Robinson 4, 2 , S. S. Lee 4, 2 , S. S. Sadhal 1, 2 . 1 Aerospace<br />
& Mechanical Engineering, University of Southern<br />
California, Los Angeles, CA; 2 SAIRC, Saban<br />
Research Center, Children’s Hospital Los Angeles,<br />
Los Angeles, CA; 3 Biomedical Engineering,<br />
University of Southern California, Los Angeles,<br />
CA; 4 Global Pharmaceutical Sciences, Allergan,<br />
Inc, Irvine, CA *CR<br />
5045 — B0003 Slow-release intraocular drug<br />
delivery by injectable PEA microfibrils (DSM,<br />
NL). Gabriele Thumann 1 , G. Mihov 2 , J. Thies 2 , A.<br />
Kemp 2 , K. Morawa 1 , M. Kropp 1 . 1 Department of<br />
Ophthalmology, University of Geneva, Geneva,<br />
Switzerland; 2 DSM, Geleen, Netherlands *CR<br />
5046 — B0004 Fucoidan but not Mannan<br />
inhibits Bevacizumab uptake independently<br />
of phagocytosis and reduces VEGF expression<br />
in the RPE. Michaela Dithmer 1 , T. Meyer 2, 3 ,<br />
E. Richert 1 , J. Roider 1 , A. K. Klettner 1 .<br />
1<br />
Ophthalmology, University of Kiel, University<br />
Medical Center, Kiel, Germany; 2 Immunology,<br />
University of Kiel, University Medical Center, Kiel,<br />
Germany; 3 Medizinische Klinik I, Charite-Campus<br />
Benjamin Franklin, Berlin, Germany *CR<br />
5047 — B0005 In Vivo Pharmacokinetics<br />
of Injectable, Intravitreal, Sustained-Release<br />
Latanoprost Formulations. William S. White, M.<br />
Hu, G. Huang, T. Pham, F. Karasina, A. Lee, M.<br />
Gorlina, V. Wong. Icon Bioscience, Inc, Sunnyvale,<br />
CA *CR<br />
5048 — B0006 Hystem, a bio-absorbable<br />
protein delivery polymer: safety, tolerability and<br />
efficacy in a rabbit corneal debridement model.<br />
MaryJane Rafii 1 , B. M. Wirostko 1, 2 , L. Werner 2 , N.<br />
Mamalis 2 , T. Zarembinski 4 , S. Pritt 3 , G. G. Gum 3 .<br />
1<br />
Ophthalmics, Jade Therapeutics, Salt Lake City,<br />
UT; 2 Ophthalmology, University of Utah, SLC, UT;<br />
3<br />
Absorption Systems, SD, CA; 4 BioTime, Almeda,<br />
CA *CR<br />
5049 — B0007 Delivery of Human Growth<br />
Hormone via DSM’s Poly(ester amide). Julien<br />
Bérard 1 , J. Zupancich 1 , A. Hecka 1 , G. Mihov 1 , S.<br />
Reiver 1 , J. Thies 1 , K. A. Messier 1 , B. M. Wirostko 2 ,<br />
M. Rafii 2 . 1 DSM, Geleen, Netherlands; 2 Jade<br />
Therapeutics, LLC, Salt Lake City, UT *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
324
<strong>Wednesday</strong> – Posters – 5050 – 5074<br />
5050 — B0008 Design of a Non-Invasive Coreshell<br />
Nanoparticulate Drug Delivery System for<br />
Posterior Part of the Eye. Binapani Mahaling, D.<br />
S. Katti. Biological Sciences and Bioengineering,<br />
Indian Institute of Technology Kanpur, Kanpur,<br />
India<br />
5051 — B0009 Development and<br />
characterization of silicone pressure sensitive<br />
adhesive episcleral implant. He Wen, S. Li.<br />
University of Cincinnati, Cincinnati, OH *CR<br />
5052 — B0010 Ocular injection characteristics<br />
and in vitro release profiles of lipophilic dye<br />
using thermogel PLGA-PE-PLGA as a sustainedrelease<br />
drug delivery device. Eva Abarca, P. M.<br />
Potter, J. H. Salmon, B. C. Gilger. North Carolina<br />
State University, Raleigh, NC *CR<br />
5053 — B0011 Development of Aqueous<br />
Nanomicellar Formulation for Topical Delivery<br />
of Biotinylated Lipid Prodrug of Acyclovir to<br />
Treat Herpetic Keratitis. Aswani Dutt Vadlapudi,<br />
K. Cholkar, R. Vadlapatla, A. K. Mitra. Division of<br />
Pharmaceutical Sciences, University of Missouri-<br />
Kansas City, Kansas City, MO<br />
5054 — B0012 Dexamethasone Sustained<br />
Delivery From Polyesteramide Microspheres<br />
For Intraocular Administration. Influence<br />
Of Sterilization. Vanessa Andres-Guerrero 1 , M.<br />
Zong 2 , G. Mihov 2 , A. A. Dias 2 , R. Herrero-Vanrell 1 .<br />
1<br />
Pharmaceutical Technology, Faculty of Pharmacy/<br />
Complutense University, Madrid, Spain; 2 DSM,<br />
Geleen, Netherlands *CR<br />
5055 — B0013 Pharmacodynamic study<br />
of Intravitreal liposomal doxorubicin by<br />
matrix-assisted laser desorption/ionizationmass<br />
spectrometry (MALDI/MS). Hsi-Kung<br />
Kuo, Y. Chen, P. Wu. Ophthalmology, Kaohsiung<br />
Chang Gung Memorial Hospital and Chang Gung<br />
University College of Medicine, Kaohsiung, Taiwan<br />
5056 — B0014 Cavernous Sinus as Ocular<br />
Pharmacokinetic Compartment for Better<br />
Understanding of Posterior Segment and<br />
Contralateral Eye Drug Availability. Muhammad<br />
Abdulrazik. Ophthal/Innovative Interventions, East<br />
Jerusalem Biomedical Institute, East Jerusalem,<br />
Occupied Palestinian Territory<br />
5057 — B0015 Influence of Physicochemical<br />
Properties on Drug Delivery across Sclera into<br />
Choroid-Retina. Ayumi Yoshimatsu 1 , C. Yabuta 1 ,<br />
A. Ohtori 1, 2 , M. Azuma 1 . 1 Senju Laboratory of<br />
Ocular Sciences, Senju Pharmaceutical Co., Ltd.,<br />
Kobe, Japan; 2 Laboratory of Ocular Drug Delivery<br />
System, Kyushu Institute of Technology, Fukuoka,<br />
Japan *CR<br />
5058 — B0016 Sustained Prednisolone<br />
Acetate-loaded Microfilm Drug Delivery System<br />
Effectively Prolongs corneal allograft survival<br />
in the rat keratoplasty model. Yu-Chi Liu 1, 2 , Y.<br />
Peng 3 , N. Lwin 1 , S. Venkatraman 3 , T. Wong 1, 2 , J.<br />
S. Mehta 1, 2 . 1 Singapore Eye Research Institute,<br />
Singapore, Singapore; 2 Singapore National Eye<br />
Centre, Singapore, Singapore; 3 School of Materials<br />
Science and Engineering, Nanyang Technological<br />
University, Singapore, Singapore *CR<br />
5059 — B0017 Treatment of Acute Posterior<br />
Uveitis by Injection of Triamcinolone<br />
Acetonide into the Suprachoroidal Space Using<br />
Microneedles. Brian C. Gilger 1 , E. M. Abarca 1 , J.<br />
H. Salmon 1 , S. R. Patel 2 . 1 Clinical Sciences, North<br />
Carolina State University, Raleigh, NC; 2 Clearside<br />
Biomedical, Alpharetta, GA *CR<br />
5060 — B0018 Ocular and Systemic<br />
Pharmacokinetics of a PDE4 Inhibitor Following<br />
Topical Administration (Eyedrop) in Male<br />
Dutch-Belted Rabbits. David C. Gale 1 , C. J.<br />
Sychterz 2 , C. Rodgers 2 , S. Wang 2 , T. Wilde 2 , A.<br />
Krishnatry 2 , H. Ellens 2 . 1 Ophthalmology DPU,<br />
GlaxoSmithKline, King of Prussia, PA; 2 PTS<br />
DMPK-UM, GlaxoSmithKline, King of Prussia,<br />
PA *CR<br />
5061 — B0019 Aqueous humor concentration<br />
of Bromfenac 0.09% (Bromday) compared with<br />
Bromfenac in DuraSite 0.075% (Bromsite) in<br />
cataract patients undergoing phacoemulsification<br />
after 3 days dosing. Kamran Hosseini 1 , J.<br />
Hutcheson 1 , L. M. Bowman 2 . 1 Clinical, InSite Vision<br />
Inc, Alameda, CA; 2 Development, InSite Vision,<br />
Alameda, CA *CR, f<br />
5062 — B0020 Comparison of the Total<br />
Amount of Triamcinolone Acetonide<br />
Delivered Via Suprachoroidal or Intravitreal<br />
Administration. Brian Burke, R. S. Verhoeven, S.<br />
R. Patel. Clearside Biomedical, Raleigh, NC *CR<br />
5063 — B0021 Suprachoroidal Microinjection<br />
Delivers Triamcinolone Acetonide to<br />
Therapeutically-Relevant Posterior Ocular<br />
Structures and Limits Exposure in the Anterior<br />
Segment. Henry F. Edelhauser 1, 2 , S. R. Patel 2 , C.<br />
Meschter 3 , R. Dean 3 , K. Powell 4 , R. S. Verhoeven 2 .<br />
1<br />
Ophthalmology, Emory Univ Eye Center,<br />
Atlanta, GA; 2 Clearside Biomedical, Alpharetta,<br />
GA; 3 Comparative Biosciences, Sunnyvale, CA;<br />
4<br />
Tandem Labs, Durham, NC *CR<br />
5064 — B0022 Protective Effects of<br />
Transscleral Drug Delivery Device Against<br />
Photoreceptor Cell Death in S334ter Rhodopsin<br />
Mutant Rats. Nobuhiro Nagai 1 , H. Kaji 2 , H.<br />
Onami 1 , T. Yamada 2 , Y. Katsukura 1 , Y. Ishikawa 1 ,<br />
M. Nishizawa 2 , Y. Mashima 3 , T. Abe 1 . 1 Graduate<br />
School of Medicine, Tohoku University, Sendai,<br />
Japan; 2 Graduate School of Engineering, Tohoku<br />
University, Sendai, Japan; 3 R-Tech Ueno, Tokyo,<br />
Japan *CR<br />
5065 — B0023 In vitro cytotoxicity screening<br />
and pharmacokinetic modeling: a tool in the<br />
development of ocular drug delivery systems.<br />
Eva Tuominen 1 , G. Mihov 2 , M. Zong 2 , S. Sarkhel 1 ,<br />
A. A. Dias 2 , A. Urtti 1 . 1 Centre for Drug Research,<br />
Faculty of Pharmacy, University of Helsinki,<br />
Helsinki, Finland; 2 DSM, Geleen, Netherlands *CR<br />
5066 — B0024 Retinal Safety and Efficacy of<br />
a Dexamethasone Biodegradable Implant to<br />
Treat Macular Edema Associated to Retinal Vein<br />
Occlusion: A Phase I/II Clinical Trial. Rubens C.<br />
Siqueira 1 , R. B. Cunha 1 , A. Messias 1 , A. S. Cunha 2 ,<br />
S. Fialho 2 , R. Jorge 1 . 1 Retina, Sao Paulo University,<br />
Sao Jose do Rio Preto, Brazil; 2 Pharmacology,<br />
Minas Gerais Federal University, Belo Horizonte,<br />
Brazil f<br />
5067 — B0025 Therapeutic effect of<br />
stealth-type polymeric nanoparticles with<br />
encapsulated cyclosporine A on experimental<br />
autoimmune uveoretinitis. Tsutomu Sakai 1 , K.<br />
Kuroyanagi 1 , T. Ishihara 2 , K. Okano 1 , H. Tsuneoka 1 .<br />
1<br />
Ophthalmology, Jikei Univ School of Medicine,<br />
Setagaya-ku, Japan; 2 Chemical biology and applied<br />
chemistry, Nihon university college of engineering,<br />
Kooriyama, Japan<br />
5068 — B0026 Development of an in vitro<br />
pharmacokinetic model of the human eye.<br />
Sahar Awwad 1, 2 , A. Lockwood 1, 2 , A. Mohamed<br />
Ahmed 1, 2 , G. Sharma 1, 2 , A. Khalili 2 , S. Brocchini 1, 2 ,<br />
P. T. Khaw 2 . 1 UCL School of Pharmacy, London,<br />
United Kingdom; 2 National Institute for Health<br />
Research (NIHR) Biomedical Research Centre at<br />
Moorfields Eye Hospital NHS Foundation Trust and<br />
UCL Institute of Ophthalmology, London, United<br />
Kingdom *CR<br />
5069 — B0027 Tunable sustained intravitreal<br />
drug delivery system for daunorubicin using<br />
oxidized porous silicon. Huiyuan Hou 1 , A.<br />
Nieto 2 , F. Ma 1 , S. Lee 1 , K. Nan 1 , W. R. Freeman 1 ,<br />
M. J. Sailor 2, 3 , L. Cheng 1 . 1 Department of<br />
Ophthalmology, Shiley Eye Center, UCSD,<br />
San Diego, CA; 2 Department of Chemistry and<br />
Biochemistry, UCSD, San Diego, CA; 3 Department<br />
of Bioengineering, UCSD, San Diego, CA *CR<br />
5070 — B0028 3D Computational Fluid<br />
Dynamic Simulation of an Intravitreal<br />
Brimonidine Implant in the Rabbit Eye. Julie<br />
E. Whitcomb 1 , S. S. Lee 2 , B. D. Swift 1 , J. Rowe 3 ,<br />
M. R. Kazemi 4 , J. Shen 1 . 1 Pharmacokinetics<br />
& Drug Disposition, Allergan, Irvine, CA;<br />
2<br />
Ophthalmology Clinical Research, Allergan, Irvine,<br />
CA; 3 Bioanalytical Sciences, Allergan, Irvine, CA;<br />
4<br />
Independent Engineer Consultant, San Jose, CA<br />
*CR<br />
5071 — B0029 Optimization of In-vitro<br />
DiffER model to study/compare the effect<br />
of Formulations on Cross-Scleral transport<br />
of poorly aqueous soluble drug. Thomas E.<br />
Rowe 1 , K. W. Reed 2, 1 , T. Bhowmik 1 . 1 Encompass<br />
Pharmaceutical Services, Norcross, GA;<br />
2<br />
Pharmaceutical Sciences, Belmont University,<br />
Nashville, TN *CR<br />
5072 — B0030 Ocular bioavailability of<br />
brimonidine 0.1% BID in non-human primates.<br />
Chinatsu Tosha, S. Decker, G. Ruiz, O. Avalos, W.<br />
Orilla, L. Gruber, T. Lin, A. S. Almazan, D. W. Gil,<br />
J. A. Burke. Biological Science, Allergan, Inc.,<br />
Irvine, CA *CR<br />
5073 — B0031 Sustained Delivery of<br />
Prostaglandin from Drug-Containing Depots<br />
Using Ocular Rings in Beagles. Kathryn S.<br />
Crawford 1 , J. Y. Ellis 2 , J. Rulander 3 , S. Johnston 3 ,<br />
F. S. Lai 3 , E. J. Ellis 2 , C. D. Leahy 2 . 1 PharmOcu,<br />
Andover, MA; 2 Vista Scientific, LLC, Andover,<br />
MA; 3 Massachusetts Medical Device Development<br />
Center, University of Massachusetts, Lowell, MA<br />
*CR<br />
5074 — B0032 Evaluating & Predicting Drug<br />
Release from an Implantable Biomaterial. Ivana<br />
Postic, H. Sheardown. Chemical Engineering,<br />
McMaster University, Hamilton, ON, Canada *CR<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
325
5075 – 5094 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
5075 — B0033 A hollow metal microneedle<br />
reduce reflux in intravitreal injections. SungHo<br />
Lee 1 , D. Lee 2 , Y. You 2 , S. Kim 2 , C. Lee 3 , H. Jung 3 , S.<br />
Lee 4 , O. Kwon 2 . 1 R&D Center, Lumieye Genetics<br />
Co., Ltd., Seoul, Republic of Korea; 2 Retina center,<br />
NUNE Eye Hospital, Seoul, Republic of Korea;<br />
3<br />
Biotechnology, Yonsei University, Seoul, Republic<br />
of Korea; 4 Ophthalmology, Soonchunhyang<br />
University Hospital, Seoul, Republic of Korea<br />
Exhibit Hall B0034-B0058<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Visual Neuroscience<br />
469 Dysfunction in Disease:<br />
Translational Studies<br />
Moderator: Erika D. Eggers<br />
5076 — B0034 Evidence Suggesting Retinotopic<br />
and Age Variability in Rate of Photoreceptor<br />
Loss Following Bright Light Exposure in<br />
Neonatal Rats. Anna Polosa, P. Lachapelle.<br />
Ophthalmology/Neurology-Neurosurgery, McGill<br />
University/Montreal Children’s Hospital, Montreal,<br />
QC, Canada<br />
5077 — B0035 Neonatal Hypoxia-Ischemia<br />
Retinopathy: Severity at Onset Determines<br />
Fate. Suna Jung 1, 2 , A. Polosa 2 , P. Lachapelle 2 ,<br />
P. Wintermark 1 . 1 Newborn Medicine, Montreal<br />
Children’s Hospital, Montreal, QC, Canada;<br />
2<br />
Ophthalmology and Neurology-Neurosurgery,<br />
Research Institute of Montreal Children’s Hospital,<br />
McGill University, Montreal, QC, Canada<br />
5078 — B0036 Oxidative-Retinopathies:<br />
Female Neonate Rats Handle Bright Light<br />
Better Than Hyperoxia, Males React Strongly<br />
To Both. Samaneh Chaychi 1 , S. Chorfi 1 , A. Polosa 1 ,<br />
S. Jung 1 , A. L. Dorfman 1 , X. Yang 1 , S. Chemtob 2 ,<br />
P. Lachapelle 1 . 1 Ophthalmology-Neurology/<br />
Neurosurgery, McGill Univ/Montreal Children’s<br />
Hosp, Montreal, QC, Canada; 2 Pharmacology,<br />
McGill Univ/Montreal Children’s Hosp, Montreal,<br />
QC, Canada<br />
5079 — B0037 Effects of vitamin A on a rat<br />
model of retinopathy of prematurity (ROP). Julie<br />
A. Mocko 1 , Y. Wei 2 , L. J. Frishman 1 , X. I. Couroucli 2 .<br />
1<br />
College of Optometry, University of Houston,<br />
Houston, TX; 2 Section of Neonatology, Department<br />
of Pediatrics, Baylor College of Medicine, Houston,<br />
TX<br />
5080 — B0038 Scotopic Spatial Summation<br />
in Retinopathy of Prematurity (ROP). Jena<br />
Tavormina 1, 2 , R. M. Hansen 1, 2 , A. Moskowitz 1, 2 , A.<br />
B. Fulton 1, 2 . 1 Ophthalmology, Boston Children’s<br />
Hospital, Boston, MA; 2 Harvard Medical School,<br />
Boston, MA<br />
5081 — B0039 Activation of Pannexin1<br />
channel induces ganglion cell loss in retinal<br />
ischemia. Valery I. Shestopalov 1, 2 , A. Toychiev 3 ,<br />
G. Dvoriantchikova 1 , C. Yee 3 , A. Pronin 1, 4 , V. Z.<br />
Slepak 4 , B. T. Sagdullaev 3, 5 . 1 Bascom Palmer Eye<br />
Institute Dept. Ophthalmology, University of Miami<br />
Miller School of Medicine, Miami, FL; 2 Vavilov<br />
Institute of General Genetics, Moscow, Russian<br />
Federation; 3 Ophthalmology, Weill Medical College<br />
of Cornell University, White Plains, NY; 4 Molecular<br />
Pharmacology, University of Miami Miller School<br />
of Medicine, Miami, FL; 5 Winifred Masterson<br />
Burke Medical Research Institute, White Plains, NY<br />
5082 — B0040 Over-Expression of Dystrophin<br />
Isoform Dp71 Does Not Alter the Mouse ERG.<br />
De-Ann M. Pillers 1, 2 , W. Luo 1 , S. A. Tokarz 1 , P. N.<br />
Ray 4 , B. R. Pattnaik 1, 3 . 1 Department of Pediatrics,<br />
University of Wisconsin-Madison, Madison, WI;<br />
2<br />
McPherson Eye Research Institute, University of<br />
Wisconsin, Madison, WI; 3 Ophthalmology & Visual<br />
Science, University of Wisconsin, Madison, WI;<br />
4<br />
Hospital for Sick Children, University of Toronto,<br />
Toronto, ON, Canada<br />
5083 — B0041 Reduction of ERG Amplitude<br />
during light adaptation in Pikachurin nullmutant<br />
mice. Masatoshi Nagaya 1 , S. Ueno 1 , M.<br />
Kondo 2 , T. Furukawa 3 , H. Terasaki 1 . 1 Nagoya<br />
University, Nagoya, Japan; 2 Mie Univ Graduate<br />
School of Med, Tsu, Japan; 3 Institute for Protein<br />
Research, Osaka & JST, CREST, Osaka, Japan<br />
5084 — B0042 Alterations in the mGluR6<br />
signaling complex in the retina of mdx 3Cv mice,<br />
a model of Duchenne Muscular Disease. Michel<br />
J. Roux 1 , A. Philipps 1 , C. Chapot 1 , J. A. Sahel 2, 3 , A.<br />
Rendon 2 . 1 Translational Medicine & Neurogenetics,<br />
IGBMC, CNRS UMR7104 - Université de<br />
Strasbourg, Inserm U964, Illkirch, France;<br />
2<br />
Institut de la Vision, Inserm UMR_S968, CNRS<br />
UMR_7210, Université Pierre et Marie Curie<br />
Paris 06, Paris, France; 3 Centre d’Investigation<br />
Clinique 503, Inserm-Centre Hospitalier National<br />
d’Ophtalmologie des Quinze-Vingts, Paris, France<br />
*CR<br />
5085 — B0043 Evaluation of retinal and optic<br />
nerve stress in Wfs1-/- mouse model of Wolfram<br />
syndrome. Delphine M. Bonnet Wersinger 1 , C. P.<br />
Hamel 1 , Y. Tanizawa 2 , G. Lenaers 1 , C. Delettre 1 .<br />
1<br />
Montpellier Neuroscience Institute, INSERM<br />
U1051, Montpellier, France; 2 Center for Reparative<br />
Medicine Graduate School of Medicine, Yamaguchi<br />
University, Yamaguchi, Japan<br />
5086 — B0044 Impaired Functional<br />
Connectivity in the Visual Pathway in Monkeys<br />
Deficient in Omega-3 Fatty Acids. Martha<br />
Neuringer 1 , D. S. Grayson 2 , C. D. Kroenke 1, 3 , L.<br />
Renner 1 , A. R. Weiss 1 , D. A. Fair 2, 3 . 1 Neuroscience,<br />
Oregon National Primate Research Center,<br />
Beaverton, OR; 2 Behavioral Neuroscience,<br />
Oregon Health & Science University, Portland,<br />
OR; 3 Advanced Imaging Research Center, Oregon<br />
Health & Science University, Portland, OR *CR<br />
5087 — B0045 A novel knock-in model for<br />
the Y141C pattern dystrophy mutation in RDS.<br />
Michael Stuck, S. M. Conley, M. I. Naash. Univ of<br />
Oklahoma Hlth Sci Ctr, Oklahoma City, OK<br />
5088 — B0046 Elucidation of<br />
physiopathological mechanisms of GPR179.<br />
Elise Orhan 1 , L. Prezeau 5 , C. Michiels 1 , C. Vol 5 ,<br />
J. A. Sahel 2, 3 , I. S. Audo 4, 3 , C. Zeitz 1 . 1 Institut de<br />
la Vision, Univ Pierre et Marie Curie Paris 6,<br />
INSERM, UMR_S968; CNRS, UMR_7210, Paris ,<br />
F-75012, France; 2 Univ Pierre et Marie Curie Paris<br />
6, INSERM, UMR_S968; CNRS, UMR_7210;<br />
CHNO, INSERM-DHOS CIC 503; Fondation<br />
Ophtalmologique Adolphe de Rothschild, Paris;<br />
Académie des Sciences-Institut de France, Paris ,<br />
F-75012, France; 3 UCL-Institute of Ophthalmology,<br />
11-43 Bath Street, London EC1V 9EL, United<br />
Kingdom; 4 Univ Pierre et Marie Curie Paris 6,<br />
INSERM, UMR_S968; CNRS, UMR_7210;<br />
CHNO, INSERM-DHOS CIC 503, Paris , F-75012,<br />
France; 5 Institut de Génomique Fonctionnelle<br />
CNRS UMR5203, INSERM U661, UM1 & UM2,<br />
Montpellier, France *CR<br />
5089 — B0047 Dry Eye and Headache Mouse<br />
Clinical Models of Photophobia. Anna Matynia 1, 2 ,<br />
S. Parikh 1, 2 , A. Charles 2, 3 , M. B. Gorin 1, 2 . 1 Jules<br />
Stein Eye Institute, UCLA, Los Angeles, CA;<br />
2<br />
Brain Research Institute, UCLA, Los Angeles, CA;<br />
3<br />
Neurology, UCLA, Los Angeles, CA *CR<br />
5090 — B0048 Intravitreal injection of<br />
acyclovir causes dose-related retinal toxicity in<br />
rabbits. Gabriela L. Ioshimoto 1 , B. Takahashi 2 , C.<br />
N. Pessoa 3 , A. M. Liber 1 , B. V. Nagy 1 , D. F. Ventura 1 ,<br />
F. Damico 2 . 1 Department Experimental Psychology,<br />
Psychology Institute, University of Sao Paulo, São<br />
Paulo, Brazil; 2 Department of Ophthalmology,<br />
University of Sao Paulo, Sāo Paulo, Brazil;<br />
3<br />
Department of Cell and Developmental Biology,<br />
Biomedical Sciences Institute, University of Sao<br />
Paulo, São Paulo, Brazil<br />
5091 — B0049 Retinal Degeneration in the<br />
Royal College of Surgeons Rat - A Study on<br />
Electrophysiological Properties. Stephan Hesse 1 ,<br />
C. Haselier 1 , S. Johnen 1 , T. Baltz 2 , G. Roessler 1 ,<br />
B. A. Mazinani 1 , P. Walter 1 . 1 Department of<br />
Ophthalmology, RWTH Aachen University, Aachen,<br />
Germany; 2 Department of Technical Science and<br />
Business Development, University of Erfurt, Erfurt,<br />
Germany *CR<br />
5092 — B0050 Light-evoked Response<br />
Recordings from Degenerating Mouse<br />
Retina: Effect of Valproic Acid Application on<br />
Spontaneous Activity. Jun Kaneko, M. Mandai, M.<br />
Takahashi. Lab for Retinal Regeneration, RIKEN<br />
Ctr for Developmental Biol, Kobe, Japan<br />
5093 — B0051 Retinal Inhibitory Signaling is<br />
Increased in Streptozotocin-induced Diabetes.<br />
Johnnie Moore-Dotson 1 , R. Mazade 1 , A. S.<br />
Berstein 1, 2 , M. J. Romero-Aleshire 1 , H. Brooks 1 , E.<br />
D. Eggers 1, 2 . 1 Physiology, University of Arizona,<br />
Tucson, AZ; 2 Biomedical Engineering, University<br />
of Arizona, Tucson, AZ<br />
5094 — B0052 The retinal phenotype of an<br />
animal model of the HANAC syndrome. Alix<br />
Trouillet 1 , E. Plaisier 2 , H. Lorach 1 , J. Dégardin 1 , M.<br />
Simonutti 1 , M. Paques 1 , J. A. Sahel 1 , P. Ronco 2 , S.<br />
A. Picaud 1 . 1 Institut de la Vision, INSERM/CNRS/<br />
UPMC/CHNO des XV-XX, Paris, France; 2 APHP-<br />
Hôpital Tenon, Paris, France *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
326
<strong>Wednesday</strong> – Posters – 5095 – 5112<br />
5095 — B0053 Visual Deficits in Mice after<br />
Mild Traumatic Brain Injury Produced using<br />
A Novel Closed-head Model of Primary<br />
Overpressure Blast. Tonia S. Rex 1 , A. J. Elberger 2 ,<br />
Y. Deng 2 , N. H. Guley 2 , J. Hines-Beard 1 , L.<br />
D’Surney 2, 3 , N. Del Mar 2 , M. G. Honig 2 , A.<br />
Reiner 2, 3 . 1 Ophthalmology & Visual Sciences,<br />
Vanderbilt University, Nashville, TN; 2 Anatomy<br />
& Neurobiology, University of Tennessee Health<br />
Science Center, Memphis, TN; 3 Ophthalmology,<br />
University of Tennessee Health Science Center,<br />
Memphis, TN *CR<br />
5096 — B0054 Morphological and Functional<br />
Study of Retinal Astrocytes in DBA/2J Mice.<br />
Laura Fernandez-Sanchez 1 , L. Perez de Sevilla<br />
Muller 2 , N. Brecha 2, 3 , N. Cuenca 1 . 1 Physiology,<br />
Genetics & Microbiology, University of Alicante,<br />
Alicante, Spain; 2 Neurobiology, David Geffen<br />
School of Medicine at UCLA, Los Angeles, CA;<br />
3<br />
Veterans Administration, Greater Los Angeles<br />
Healthcare System, Los Angeles, CA *CR<br />
5097 — B0055 Axonal Transport Disruption<br />
in Retinal Ganglion Cells Following Transient<br />
Increase in Intraocular Pressure. Andrea C.<br />
Nuschke 1, 2 , X. Wang 1, 2 , N. O’Leary 1, 3 , C. A.<br />
Smith 1, 2 , B. C. Chauhan 1, 3 . 1 Retina and Optic Nerve<br />
Research Laboratory, Dalhousie University, Halifax,<br />
NS, Canada; 2 Physiology and Biophysics, Dalhousie<br />
University, Halifax, NS, Canada; 3 Ophthalmology<br />
and Visual Sciences, Dalhousie University, Halifax,<br />
NS, Canada<br />
5098 — B0056 VLC-PUFA and the scotopic<br />
photoresponse. Lea D. Marchette 1 , R. A. Radu 2 , R.<br />
E. Anderson 1 . 1 Ophthalmology, Univ of Oklahoma<br />
Hlth Sci Ctr, Oklahoma City, OK; 2 UCLA, Los<br />
Angeles, CA *CR<br />
5099 — B0057 Implantation of a highdensity,<br />
flexible CMOS imaging sensor retinal<br />
prosthesis in minipig eyes. Chang-Hao Yang 1 ,<br />
L. Fan 2 , F. Yang 2 . 1 Ophthalmology, National<br />
Taiwan Univ Hospital, Taipei, Taiwan; 2 Institute<br />
of NanoEngineering and Microsystems, National<br />
Tsing-Hua University, Hsinchu, Taiwan *CR<br />
5100 — B0058 Development and Evaluation<br />
of Highly Light-Sensitive Channelrhodopsin-2<br />
Mutants for Vision Restoration. Zhuo-Hua<br />
Pan, T. Ganjawala, Z. Zhang, Q. Lu, E. Ivanova.<br />
Ophthalmology and Anatomy & Cell Biology,<br />
Wayne State Univ Sch of Med, Detroit, MI *CR<br />
Exhibit Hall B0059-B0091<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Visual Neuroscience<br />
470 Dysfunction in Disease:<br />
Clinical Studies<br />
Moderator: Carol A. Westall<br />
5101 — B0059 Wide field imaging in patients<br />
treated with vigabatrin. Catherine Brugniart 1 ,<br />
J. Bursztyn 2 , J. Motte 3 , A. Ducasse 1 , C. F. Arndt 1 .<br />
1<br />
Ophtalmologie, CHU Reims, Reims, France;<br />
2<br />
Cabinet Ophtalmologie, Paris, France; 3 American<br />
Memorial Hospital, Reims University Hospital,<br />
Reims, France *CR<br />
5102 — B0060 Association Between ERG<br />
Associated Vigabatin Toxicity and Subsequent<br />
Visual Field Reduction. Ananthavalli<br />
Kumarappah 1, 2 , Y. Reginald 2 , J. Buncic 2 , O.<br />
Snead 3 , C. A. Westall 1, 2 . 1 Institute of Medical<br />
Sciences, University of Toronto, Toronto, ON,<br />
Canada; 2 Ophthalmology and Vison Sciences, The<br />
Hospital for Sick Children, Toronto, ON, Canada;<br />
3<br />
Neurology, The Hospital for Sick Children,<br />
Toronto, ON, Canada *CR<br />
5103 — B0061 Electroretinograms Ordered<br />
for Vigabatrin Use at the Children’s Hospital<br />
Colorado. Ashley E. Laing 1 , J. L. Jung 1 , E. A.<br />
McCourt 1, 2 , R. S. Braverman 1, 2 . 1 Ophthalmology,<br />
University of Colorado, Denver, CO;<br />
2<br />
Ophthalmology, Children’s Hospital of Colorado,<br />
Aurora, CO<br />
5104 — B0062 Absence of the cone-mediated<br />
OP 3<br />
associated with Vigabatrin therapy. Julie<br />
Racine, R. Noles, J. R. Hickox, M. McGregor, D.<br />
L. Rogers. Ophthalmology, Nationwide Children’s<br />
Hospital, Columbus, OH<br />
5105 — B0063 The utility of multifocal<br />
electroretinography (mfERG) in screening<br />
for hydroxychloroquine/chloroquine induced<br />
retinopathy. Kevin Leonard, J. Gao, J. Hamilton,<br />
C. Gottlieb, S. G. Coupland. University of Ottawa<br />
Eye Institute, Ottawa, ON, Canada *CR<br />
5106 — B0064 Follow-up of patients affected<br />
by rheumathoid arthritis and connectivities,<br />
under therapy with hydroxychloroquine or<br />
chloroquine via multifocal electroretinogram,<br />
frequency doubling technology, automated<br />
perimetry, optical coherence tomography and<br />
autofluorescence. Giulio Ruberto 1 , L. Cavagna 2 ,<br />
C. Tinelli 3 , M. Raimondi 1 , V. Mogavero 1 , P.<br />
Piccinini 1 , F. Borgaro 1 , L. Bossolesi 1 . 1 Clinica<br />
Oculistica, IRCCS Policlinico San Matteo, Pavia,<br />
Italy; 2 reumatologia, IRCCS Policlinico San<br />
Matteo, Pavia, Italy; 3 Servizio di biometria, IRCCS<br />
Policlinico San Matteo, Pavia, Italy<br />
5107 — B0065 Evaluation of Inner Retinal<br />
Changes using Macular Focal Electroretinogram<br />
and Optical Coherence Tomography in Patients<br />
with Early Stage Diabetes. Manami Kuze 1, 2 , T.<br />
Tanaka 3 , H. Goto 3 , M. Kondo 2 . 1 Ophthalmology,<br />
NHO Mie Chuo Medical Center, Tsu, Japan;<br />
2<br />
Ophthalmology, Mie University School of<br />
Medicine, Tsu, Japan; 3 Internal Medicine, NHO Mie<br />
Chuo Medical Center, Tsu, Japan<br />
5108 — B0066 Relation between the fast<br />
oscillation of the EOG and ERG measures of<br />
rod photoreceptor function in healthy eyes and<br />
in diabetes. Marilyn E. Schneck, W. A. Verdon, W.<br />
Lam, K. P. Dhamdhere, T. Zeng, S. Barez, M. A.<br />
Bearse, A. J. Adams. School of Optometry-2020,<br />
UC Berkeley, Berkeley, CA<br />
5109 — B0067 PRPH2 Mutations as a Cause<br />
of Electronegative ERG. Rola Ba-Abbad 3, 1 , A. G.<br />
Robson 1, 4 , A. T. Moore 4, 2 , A. R. Webster 4, 2 , Y. Yap 2 ,<br />
G. E. Holder 1, 3 . 1 Electrophysiology, Moorfields<br />
Eye Hospital, London, United Kingdom; 2 Medical<br />
Retina & Genetics, Moorfields Eye Hospital,<br />
London, United Kingdom; 3 Visual Neuroscience,<br />
Institute of Ophthalmology, London, United<br />
Kingdom; 4 Genetics, Institute of Ophthalmology,<br />
London, United Kingdom *CR<br />
5110 — B0068 Long-Term Decay of Central<br />
Cone Function in Cone-Rod Dystrophy<br />
Evaluated by Focal Electroretinogram. Benedetto<br />
Falsini 1 , M. Piccardi 1 , L. Ziccardi 2 , A. Fadda 4 , A.<br />
M. Minnella 1 , D. Marangoni 1 , S. Bisti 6 , G. Resta 5 , L.<br />
Galli Resta 3 . 1 Ophthalmology, Universita’ Cattolica<br />
del S. Cuore, Rome, Italy; 2 Ophthalmology, Bietti<br />
Foundation IRCCS, Rome, Italy; 3 Neuroscience<br />
Institute, CNR, Pisa, Italy; 4 Health and Technology,<br />
Istituto Superiore di Sanita, Rome, Italy;<br />
5<br />
Informatics and Telematics, CNR, Pisa, Italy;<br />
6<br />
Scienze Cliniche ed Applicate Biotecnologiche,<br />
Universita dell’Aquila, L’Aquila, Italy<br />
5111 — B0069 Blue-on-yellow<br />
electroretinography on patients with enhanced<br />
S-cone syndrome. Kazuki Kuniyoshi 1 , T. Hayashi 2 ,<br />
H. Sakuramoto 1 , H. Tsuneoka 2 , Y. Shimomura 1 .<br />
1<br />
Ophthalmology, Kinki University Faculty of<br />
Medicine, Osaka-sayama, Japan; 2 Ophthalmology,<br />
The Jikei University School of Medicine, Tokyo,<br />
Japan<br />
5112 — B0070 Chromatic Full-field Stimulus<br />
Threshold (FST) in Retinitis Pigmentosa -<br />
Relationships with electroretinography and<br />
visual field outcomes. Andre Messias, K. Messias,<br />
R. S. Arcieri, V. M. Castro, R. C. Siqueira, R. Jorge.<br />
Ophthalmology, University of Sao Paulo, Ribeirao<br />
Preto, Brazil<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
327
5113 – 5133 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
5113 — B0071 Microvolt Cone<br />
Electroretinography in Type 1 and 2 Usher<br />
Syndrome. Wadih M. Zein 1 , E. T. Tsilou 1 , A.<br />
E. Turriff 1 , J. M. Schultz 3 , J. A. Muskett 4 , C.<br />
C. Brewer 4 , C. K. Zalewski 4 , K. A. King 4 , P. A.<br />
Sieving 2, 5 , B. Falsini 1, 6 . 1 Ophthalmic Genetics<br />
& Visual Function, NEI/NIH, Bethesda, MD;<br />
2<br />
National Eye Institute/NIH, Bethesda, MD;<br />
3<br />
Laboratory of Molecular Genetics, National<br />
Institute on Deafness and Other Communication<br />
Disorders (NIDCD)/NIH, Rockville, MD;<br />
4<br />
Otolaryngology Branch, National Institute on<br />
Deafness and Other Communication Disorders<br />
(NIDCD)/NIH, Rockville, MD; 5 National Institute<br />
on Deafness and Other Communication Disorders<br />
(NIDCD)/NIH, Rockville, MD; 6 Ophthalmology,<br />
Catholic University of Sacred Heart, Rome, Italy f<br />
5114 — B0072 Population receptive field<br />
estimates in V1 lesion projection zone of<br />
patients with macular degeneration onset at<br />
different ages. Yoichiro Masuda 1, 2 , M. Terao 3 , T.<br />
Haji 4 , K. Amano 5, 6 , H. Horiguchi 1, 7 , S. Ogawa 1, 7 ,<br />
I. Murakami 3 , K. Matsumoto 4 , H. Tsuneoka 1 , B.<br />
Wandell 7 . 1 Ophthalmology, Jikei Univ School of<br />
Med, Tokyo, Japan; 2 Ophthalmology, Atsugi City<br />
Hospital, Kanagawa, Japan; 3 Department of Life<br />
Sciences, The University of Tokyo, Tokyo, Japan;<br />
4<br />
Brain Science Institute, Tamagawa University,<br />
Tokyo, Japan; 5 Graduate School of Frontier<br />
Sciences, The University of Tokyo, Tokyo, Japan;<br />
6<br />
PRESTO, Japan Science and Technology Agency,<br />
Tokyo, Japan; 7 Psychology, Stanford University,<br />
Stanford, CA<br />
5115 — B0073 Visual Function Effects of<br />
Foretinib, a Dual MET/VEGFR2 Inhibitor,<br />
in a Phase 2 Study for Treatment of Papillary<br />
Renal Cell Carcinoma. Catherine Meyerle 1 , R.<br />
Srinivasan 2 , W. Linehan 2 , S. Yeh 1 , E. Y. Chew 1 , C.<br />
Chan 1 , F. Forooghian 1 , F. L. Ferris 1 , W. M. Zein 1 .<br />
1<br />
National Eye Institute, Bethesda, MD; 2 National<br />
Cancer Institute, Bethesda, MD *CR, f<br />
5116 — B0074 Anatomical Locus of Spatial<br />
Summation within the Retina and Neuroretinal<br />
Disease. Katherine Boudreault 1 , L. A. Levin 2, 3 .<br />
1<br />
Ophthalmology, University of Montreal, Montreal,<br />
QC, Canada; 2 Ophthalmology, McGill University,<br />
Montreal, QC, Canada; 3 Ophtalmology, University<br />
of Wisconsin, Madison, WI *CR<br />
5117 — B0075 Combined Systemic Health<br />
Markers are Associated with Multifocal<br />
Electroretinogram Implicit Times in Healthy<br />
Subjects with no Eye Disease. Wendy W.<br />
Harrison, V. Yevseyenkov, C. Sorenson. Optometry,<br />
Midwestern Univ Arizona Coll of Optometry,<br />
Glendale, AZ<br />
5118 — B0076 Differences in neuroretinal<br />
function between healthy adult males and<br />
females under and over the age of 50 years.<br />
Glen Y. Ozawa 1 , M. A. Bearse 1 , W. W. Harrison 2 ,<br />
K. W. Bronson-Castain 1 , M. E. Schneck 1 , S. Barez 1 ,<br />
K. P. Dhamdhere 1 , B. E. Wolff 1 , A. J. Adams 1 .<br />
1<br />
UC Berkeley School of Optometry, Berkeley,<br />
CA; 2 Midwestern University Arizona College of<br />
Optometry, Glendale, AZ<br />
5119 — B0077 Analysis of electroretinograms<br />
performed from 2009 to 2011 at Children’s<br />
Hospital Colorado. Jennifer L. Jung 1 , A. E.<br />
Laing 1 , E. A. McCourt 2, 1 , R. S. Braverman 2, 1 .<br />
1<br />
Ophthalmology, University of Colorado, Aurora,<br />
CO; 2 Ophthalmology, Children’s Hospital Colorado,<br />
Aurora, CO<br />
5120 — B0078 Electroretinographic assessment<br />
of retinal function at high altitude. Andreas<br />
Schatz 1 , G. Willmann 1 , M. Fischer 1, 2 , K. Schommer 3 ,<br />
A. Messias 4 , E. Zrenner 1 , K. Bartz-Schmidt 1 , F.<br />
Gekeler 1 . 1 Centre for Ophthalmology, University<br />
of Tuebingen, Tuebingen, Germany; 2 Department<br />
of Clinical Neurosciences, University of Oxford,<br />
Oxford, United Kingdom; 3 Department of Sports<br />
Medicine, University of Heidelberg, Heidelberg,<br />
Germany; 4 Department of Ophthalmology, School<br />
of Medicine of Ribeirão Preto-University of São<br />
Paulo, São Paulo, Brazil *CR<br />
5121 — B0079 Unilateral Post Operative Visual<br />
Loss with Total Ophthalmoplegia due to central<br />
retinal artery occlusion following Cervical Spine<br />
surgery in Prone Position. Vishal Jindal 1 , A. Raj 1 ,<br />
D. Kapoor 2 . 1 Ophthalmology, GMCH, Chandigarh,<br />
India; 2 Anesthesia, GMCH, Chandigarh, India<br />
5122 — B0080 A study on visual status<br />
in children with autistic spectral disease at<br />
Shraddha Center in Hyderabad City. Shata<br />
Roopa Reddy Pebbeti 1, 2 , K. Challa 1 , G. D. Vatti 1 ,<br />
P. Jagana 1 , G. K. Vemuganti 1 . 1 School of Medical<br />
Sciences, University of Hyderabad, Hyderabad,<br />
India; 2 Brienholden Vision Institute, University of<br />
New South Wales, Sydney, NSW, Australia<br />
5123 — B0081 Prognostic Value of Photopic<br />
Negative Response in Retinal Vein Occlusion<br />
after Anti-VEGF treatment. Tae Kwann<br />
Park, J. Hyun, S. An, Y. Ohn. Ophthalmology,<br />
Soonchunhyang Univ Hospital, Bucheon-si,<br />
Republic of Korea<br />
5124 — B0082 Electronretinogram and<br />
aqueous vascular endotheril growth factor in<br />
the eyes with hemi-central retinal vein occlusion<br />
or branch retinal vein occlusion. Shu Kachi, S.<br />
Yasuda, H. Ushida, M. Kondo, S. Ueno, C. Piao,<br />
H. Terasaki. Ophthalmology, Nagoya University,<br />
Nagoya, Japan<br />
5125 — B0083 Central retina vein occlusion<br />
and diabetic retinopathy treated with intravitreal<br />
dexamethasone and bevacizumab: a morphofunctional<br />
analysis. Sara Lombardo, M. Imparato,<br />
G. Ruberto, V. Mogavero, L. Giannì, F. Marzi, A.<br />
Amisano, A. Bianchi, P. Bianchi, G. Vandelli. Eye<br />
Clinic, IRCCS Policlinico San Matteo, Pavia, Italy<br />
5126 — B0084 Retinal blood flow levels<br />
measured by Laser Speckle Flowgraphy in<br />
central retinal vein occlusion as a predictive<br />
factor for ischemia and visual loss. Makiko<br />
Matsumoto, K. Suzuma, Y. Yamada, E. Tsuiki, A.<br />
Fujikawa, T. Kitaoka. Ophthalmology, Department<br />
of Ophthalmology and Visual Sciences, Graduate<br />
School of Biomedical Sciences, Nagasaki<br />
University, Nagasaki, Japan<br />
5127 — B0085 ERG as Indicator of Retinal<br />
Function in Persistent Fetal Vasculature. Brian<br />
Do 1 , J. H. Francis 2 , B. Marr 2 , D. H. Abramson 2 ,<br />
S. E. Brodie 1, 2 . 1 Ophthalmology, The Mount Sinai<br />
School of Medicine, New York, NY; 2 Ophthalmic<br />
Oncology, Memorial Sloan Kettering Cancer<br />
Center, New York, NY<br />
5128 — B0086 Electrophysiological Test for<br />
the Assessment of Dysfunction in Glaucoma.<br />
Momoyo K. Menz, M. G. Fendick, E. E. Sutter.<br />
Electrophysiology Laboratory, Electro-Diagnostic<br />
Imaging, Inc, Redwood City, CA *CR<br />
5129 — B0087 Relationship between amplitude<br />
of N2 of multifocal electroretinograms and<br />
retinal sensitivity in unilateral glaucoma<br />
patients. Gen Miura, S. Shirato, S. Yamamoto.<br />
Chiba university, Chiba, Japan<br />
5130 — B0088 Alteration of Photopic Negative<br />
Response of Multifocal Electroretinogram in<br />
Patients with Glaucoma. Muneyoshi Kaneko,<br />
S. Machida, Y. Hoshi, D. Kurosaka. Department<br />
of Ophthalmology, Iwate Medical University,<br />
Morioka, Japan<br />
5131 — B0089 Reproducibility of Multifocal<br />
Visual Evoked Potential (mfVEP) in Normal and<br />
Multiple Sclerosis (MS) Eyes. Divya Narayanan,<br />
H. Cheng, R. Tang, L. J. Frishman. Optometry,<br />
University of Houston, Houston, TX *CR<br />
5132 — B0090 Rates of Reliable Multifocal<br />
Visual Evoked Potential Waveforms:<br />
Comparison Between Multiple Sclerosis and<br />
Neuromyelitis Optica Patients. Lorena B. Botelho<br />
Vergara 1, 2 , P. A. Paixao 1, 2 , L. A. Fernandes 1, 2 ,<br />
E. C. Lacerda 2, 3 , G. S. Souza 2, 3 , A. L. Moura 4 ,<br />
D. F. Ventura 4 , H. Souza Cabeça 5 , A. A. Rosa 2, 6 ,<br />
L. L. Silveira 2 . 1 Instituto de Ciencias da Saude,<br />
Universidade Federal do Para, Belem, Brazil;<br />
2<br />
Nucleo de Medicina Tropical, Universidade Federal<br />
do Para, Belem, Brazil; 3 Instituto de Ciencias<br />
Biologicas, Universidade Federal do Para, Belem,<br />
Brazil; 4 Instituto de Psicologia, Universidade de<br />
Sao Paulo, Belem, Brazil; 5 Hospital Ophyr Loiola,<br />
Belem, Brazil; 6 Hospital Univesitario Bettina Ferro<br />
de Souza, Belem, Brazil<br />
5133 — B0091 Patients with severe<br />
impairment in one eye show improved<br />
performance to defocus-induced blur. Trisevgeni<br />
Giannakopoulou 1 , S. Plainis 1, 2 , J. Moschandreas 3 ,<br />
I. G. Pallikaris 1 , M. K. Tsilimbaris 1 . 1 Institute of<br />
Vision and Optics (IVO), University of Crete,<br />
Heraklion, Crete, Greece; 2 Faculty of Life Sciences,<br />
The University of Manchester, Manchester, United<br />
Kingdom; 3 Department of Social Medicine,<br />
University of Crete, Heraklion, Crete, Greece<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
328
<strong>Wednesday</strong> – Posters – 5134 – 5157<br />
Exhibit Hall B0138-B0169<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Retinal Cell Biology<br />
471 Retinal Development II: Retina<br />
and Vasculature<br />
Moderator: Xiuqian Mu<br />
5134 — B0138 Analysis of Cell Death Pathways<br />
in Developing Retina. Shuai Li 1 , P. G. Fuerst 1, 2 .<br />
1<br />
Neuroscience, University of Idaho, Moscow, ID;<br />
2<br />
WWAMI Medical Education Program, University<br />
of Idaho, Moscow, ID<br />
5135 — B0139 Axin2 Disruption Causes Ocular<br />
Defects During Mouse Eye Development. Sabine<br />
Fuhrmann, M. Gibbons, A. Alldredge. Ophthal &<br />
Vis Sci, University of Utah, Salt Lake City, UT<br />
5136 — B0140 Mechanisms of retinal bipolar<br />
cell genesis in Blimp1 (Prdm1) mutant mice.<br />
Joseph A. Brzezinski 1 , K. Park 1 , T. A. Reh 2 .<br />
1<br />
Ophthalmology, University of Colorado Denver,<br />
Aurora, CO; 2 Biological Structure, University of<br />
Washington, Seattle, WA<br />
5137 — B0141 Disruption of ocular<br />
development and function in Prickle 1 (Pk1)<br />
mutant mouse. Chunqiao Liu 1 , H. Qian 2 , A.<br />
Swaroop 1 , T. Li 1 . 1 Neurobiology Neurodegeneration<br />
& Repair Laboratory (N-NRL), National Eye<br />
Institute, Bethesda, MD; 2 Visual Function Core,<br />
National Eye Institute, Bethesda, MD<br />
5138 — B0142 Role of HDACS in the<br />
development and maintenance of the retinal<br />
ganglion cell layer in chick retina. Ankita Saha, T.<br />
L. Belecky-Adams. Department of Biology Center<br />
for Regenerative Biology and Medicine, Indiana<br />
University Purdue University at Indianapolis,<br />
Indianapolis, IN<br />
5139 — B0143 Pattern of Protein<br />
Phosphorylation in Wild Type and Rd1 Mouse<br />
Retina. Ju Zhang, J. M. Ogilvie. Saint Louis<br />
University, Saint Louis, MO<br />
5140 — B0144 Calcium binding proteins<br />
neuroplasticity in vertebrate retinas exposed to<br />
dim light. Nicolas S. Fosser, A. R. Paganelli, H.<br />
Rios. Instituto de Biologia Celular y Neurociencias,<br />
Facultad de Medicina, Universidad de Buenos<br />
Aires, Buenos Aires, Argentina<br />
5141 — B0145 The Matricellular Protein<br />
CCN1 is Required for Growth, Maturation and<br />
Stabilization of the Retinal Vasculature. Chintala<br />
Hemabindu 1 , J. Choi 1 , J. Shan 1 , M. B. Grant 2 ,<br />
B. Chaqour 1 . 1 Cell Biology and Ophthalmology,<br />
SUNY Downstate Medical Center, Brooklyn, NY;<br />
2<br />
Pharmacology and Therapeutics, University of<br />
Florida, Gainesville, FL<br />
5142 — B0146 Blood Vessel Pattern in<br />
Subjects with Albinism. Miriam Ehrenberg 1 , R.<br />
M. Hansen 1, 2 , A. Moskowitz 1, 2 , A. B. Fulton 1, 2 .<br />
1<br />
Department of Ophthalmology, Boston Children’s<br />
Hospital, Boston, MA; 2 Harvard Medical School,<br />
Boston, MA<br />
5143 — B0147 The expression of nestin during<br />
the vascular development in mouse retina. Yong<br />
Woo Kim 1, 2 , D. Jo 2 , H. Jun 2 , J. Kim 2 , J. Kim 1, 2 .<br />
1<br />
Department of Ophthalmology, Seoul National<br />
University College of Medicine, Seoul National<br />
University Hospital, Seoul, Republic of Korea;<br />
2<br />
Fight against Angiogenesis-Related Blindness<br />
(FARB) Laboratory, Clinical Research Institute,<br />
Seoul National University Hospital, Seoul, Republic<br />
of Korea<br />
5144 — B0148 Development of the Rodent<br />
Inner Blood-Retinal-Barrier. Ewa C. Kubala 1 , R.<br />
J. Mrsny 3 , L. Paneghetti 1 , D. T. Shima 1, 2 . 1 Institute<br />
of Ophthalmology, University College London,<br />
London, United Kingdom; 2 National Institute for<br />
Health Research Biomedical Research Centre,<br />
Moorfields Eye Hospital NHS Foundation Trust<br />
and UCL Institute of Ophthalmology, London,<br />
United Kingdom; 3 Department of Pharmacy and<br />
Pharmacology, University of Bath, Bath, United<br />
Kingdom *CR<br />
5145 — B0149 Role of the Early Ocular<br />
Vasculature in Regulation of Retinal<br />
Neurogenesis. Susov Dhakal 1 , C. B. Stevens 1 , O.<br />
Weiss 2 , A. Inbal 2 , D. L. Stenkamp 1 . 1 Department of<br />
Biological Sciences, University of Idaho, Moscow,<br />
ID; 2 Department of Medical Neurobiology, The<br />
Hebrew University of Jerusalem, Jerusalem, Israel<br />
5146 — B0150 A simple method for the<br />
isolation, purification and cultivation of retinal<br />
microvascular pericytes from rat. Xiaoling Liu 1, 2 ,<br />
G. Liu 1, 3 , C. Meng 4 , M. Pan 3 , Y. Zheng 3 , L. Lin 4 , L.<br />
Zhao 5 . 1 School of Optometry and Ophthalmology<br />
and Eye Hospital, Wenzhou Medical College,<br />
Wenzhou, China; 2 State Key Laboratory<br />
Cultivation Base and Key Laboratory of Vision<br />
Science,Ministry of Health P.R. China, Wenzhou,<br />
China; 3 Department of Ophthalmology, Affiliated<br />
People’s Hospital, Fujian University of Traditional<br />
Chinese Medicine, Fuzhou, China; 4 Department of<br />
Bioengineering, College of Biological Science and<br />
Biotechnology, Fuzhou University, Fuzhou, China;<br />
5<br />
Department of Cardiology, Affiliated People’s<br />
Hospital, Fujian University of Traditional Chinese<br />
Medicine, Fuzhou, China<br />
5147 — B0151 Expression of the Axonal<br />
Guidance Receptors EPHA5 and EPHA6<br />
Changes Across Retinal Development. Krista M.<br />
Beach 1 , H. M. Queener 1 , T. Kiyama 2 , S. W. Wang 2 ,<br />
D. C. Otteson 1 . 1 Optometry, University of Houston,<br />
Houston, TX; 2 Ophthalmology & Visual Science,<br />
Unviersity of Texas Medical School, Houston, TX<br />
5148 — B0152 Genetic Control of Rod Bipolar<br />
Cell Number and the Homotypic Regulation of<br />
Dendritic Field Size. Benjamin E. Reese, P. W.<br />
Keeley, I. E. Whitney, S. Borhanian. Neuroscience<br />
Research Institute, Univ of California-Santa<br />
Barbara, Santa Barbara, CA<br />
5149 — B0153 Retinal degenerative defects<br />
in the good effort mutant zebrafish are due to<br />
aberrant splicing of the chaf1b RNA. Travis J.<br />
Bailey, D. R. Hyde. Dept of Biological Sciences,<br />
University of Notre Dame, Notre Dame, IN<br />
5150 — B0154 TGF-β signaling protects<br />
retinal neurons from programmed cell death<br />
during development of the mammalian eye.<br />
Barbara M. Braunger 1 , S. M. Pielmeier 1 , C.<br />
Demmer 1 , V. I. Landstorfer 1 , D. Kawall 1 , I. Kleiter 3 ,<br />
D. Fischer 4 , H. Jägle 2 , E. R. Tamm 1 . 1 Institute of<br />
Human Anatomy and Embryology, University of<br />
Regensburg, Regensburg, Germany; 2 Department<br />
of Ophthalmology, University Clinic, Regensburg,<br />
Germany; 3 St. Josef-Hospital, Ruhr-University<br />
Bochum, Bochum, Germany; 4 Experimental<br />
Neurology, Heinrich-Heine-University Düsseldorf,<br />
Düsseldorf, Germany<br />
5151 — B0155 The role of ADAM10 in retinal<br />
development. Joseph Toonen, D. J. Sidjanin. Cell<br />
Biology, Neurobiology, and Anatomy, The Medical<br />
College of Wiscosin, Milwaukee, WI<br />
5152 — B0156 ADAM10 mediates cleavage<br />
of N-cadherin ectodomain during retinal<br />
ganglion cell differentiation in primary cultured<br />
developing chick retinal cells. Jae-Chang<br />
Jung 1 , S. Paudel 1 , Y. Kim 1, 2 , S. Jung 1 , S. Kang 1 ,<br />
S. Lee 1 , Y. Park 2 , K. Lee 2 . 1 Biology, Kyungpook<br />
national university, Daegu, Republic of Korea;<br />
2<br />
Ophthalmology, Cheil Eye Hospital, Daegu,<br />
Republic of Korea<br />
5153 — B0157 Strain dependent expression<br />
of the alternative splicing factor, Sfrs10<br />
and its requirement in rod outer segment<br />
morphogenesis. Devi Krishna Priya Karunakaran,<br />
R. N. Kanadia. Physiology and Neurobiology,<br />
University of Connecticut, Storrs, CT<br />
5154 — B0158 Myocilin modulates<br />
programmed cell death during retinal<br />
development. Marcus A. Koch 1 , B. Rosenhammer 1 ,<br />
S. E. Koschade 1 , B. M. Braunger 1 , C. Volz 2 , H.<br />
Jägle 2 , E. R. Tamm 1 . 1 Institute of Human Anatomy<br />
and Embryology, University of Regensburg,<br />
Regensburg, Germany; 2 University Clinical<br />
Center, Clinic and Policlinic for Ophthalmology,<br />
Regensburg, Germany<br />
5155 — B0159 Redundant Roles for Oc1 and<br />
Oc2 in Mouse Retinal Development. Darshan<br />
Sapkota 1, 2 , F. Wu 1, 2 , X. Mu 1, 2 . 1 Opthalmology<br />
and Biochemistry, University at Buffalo, Buffalo,<br />
NY; 2 SUNY Eye Institute, University at Buffalo,<br />
Buffalo, NY<br />
5156 — B0160 Cc2d2a is required for cilia<br />
axoneme development. Shobi Veleri 1 , S. H.<br />
Manjunath 1 , R. Sood 4 , P. Liu 4 , R. Fariss 3 , T. Li 1 ,<br />
R. A. Rachel 1 , L. Dong 2 , A. Swaroop 1 . 1 Neurobiol-<br />
Neurodegen & Repair Lab, NEI/NIH, Bethesda,<br />
MD; 2 Genetic Engineering Core, NEI/NIH,<br />
Bethesda, MD; 3 Biological Imaging Core, NEI/NIH,<br />
Bethesda, MD; 4 Genetics and Molecular Biology,<br />
NHGRI/NIH, Bethesda, MD<br />
5157 — B0161 Nuclear dynamics in retinal<br />
development and homeostasis. Didier M.<br />
Hodzic, D. Razafsky. Ophthalmology, Washington<br />
University School of Medicine, St Louis, MO<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
329
5158 – 5182 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
5158 — B0162 Molecular identity and<br />
specification of crossed versus uncrossed<br />
retinal ganglion cells. Qing Wang 1 , T. Kuwajima 2 ,<br />
I. Cerullo 2 , C. A. Mason 1, 2 . 1 Neuroscience,<br />
Ophthalmology, Columbia University, New<br />
York, NY; 2 Pathology & Cell Biology, Columbia<br />
University, New York, NY<br />
5159 — B0163 Aberrant axon development<br />
and up-regulation of c-Jun is associated with<br />
eye opening in Down’s syndrome cell adhesion<br />
molecule mutant. Dee Schramm 1 , P. G. Fuerst 1, 2 .<br />
1<br />
University of Idaho, Moscow, ID; 2 WWAMI<br />
Medical Education program, Univeristy of Idaho,<br />
Moscow, ID<br />
5160 — B0164 Angiotensin II selectively<br />
activates retinal microglia in mice. Joanna A.<br />
Phipps, N. Nag, K. A. Vessey, A. I. Jobling, E.<br />
L. Fletcher. Anatomy and Neuroscience, The<br />
Univeristy of Melbourne, Parkville, VIC, Australia<br />
*CR<br />
5161 — B0165 Expression of α-Internexin in<br />
Developing Chicken Retina. Chi-Hsiu Liu, F. Wei,<br />
C. Chien. Anatomy and Cell Biology, Department<br />
of Anatomy and Cell Biology, College of Medicine,<br />
National Taiwan University, Taipei, Taiwan<br />
5162 — B0166 Primary Culture and<br />
Characterization of Mouse Laminar Cells. Yan<br />
Guo 1 , Z. Mehrabyan 1 , C. J. Charniga 2 , S. Temple 2 ,<br />
S. L. Bernstein 1 . 1 Ophthalmology, University of<br />
Maryland Baltimore, Baltimore, MD; 2 New York<br />
Stem Cell Institute, Albany, NY *CR<br />
5163 — B0167 Nerve growth factor-mediated<br />
vascular endothelial growth factor expression of<br />
astrocyte in retinal vascular development. Jeong<br />
Hun Kim 1 , Y. Kim 1 , H. Lee 2 , S. Kim 2 , N. Jeon 2 , J.<br />
Kim 1 . 1 Ophthalmology-Coll of Med, Seoul National<br />
Univ Hospital, Seoul, Republic of Korea; 2 School<br />
of Mechanical and Aerospace Engineering, Seoul<br />
National University, Seoul, Republic of Korea<br />
5164 — B0168 Perturbations of the developing<br />
albino mouse RPE during retinal ganglion cell<br />
genesis. Lena Iwai, A. Ramos, R. Blazeski, C. A.<br />
Mason. Pathology and Cell Biology, Columbia<br />
University, New York, NY<br />
5165 — B0169 Foxk1 is expressed in the<br />
neuroretinal cells during development. Saadettin<br />
Sel 1 , C. Muenzenberg 3 , N. Nass 2 , M. Kaiser 3 ,<br />
T. Kalinski 2 , F. E. Kruse 1 , F. P. Paulsen 4 , M.<br />
Schicht 4 . 1 Ophthalmology, University Erlangen-<br />
Nuremberg, Erlangen, Germany; 2 University<br />
Magdeburg, Magdeburg, Germany; 3 University<br />
Halle/Wittenberg, Halle/Saale, Germany; 4 Anatomy<br />
II, University Erlangen-Nuremberg, Erlangen,<br />
Germany<br />
Exhibit Hall B0321-B0340<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Anatomy/Pathology<br />
472 Myopia II, AP<br />
Moderator: William K. Stell<br />
5166 — B0321 Megalin and myopia. Tina<br />
Storm 1 , S. Heegaard 2, 3 , E. I. Christensen 1 , R.<br />
Nielsen 1 . 1 Department of Biomedicine, Aarhus<br />
University, Aarhus, Denmark; 2 Eye Pathology<br />
Institute, Department of Neuroscience and<br />
Pharmacology, University of Copenhagen,<br />
Copenhagen, Denmark; 3 Department of<br />
Opthalmology, Glostrup Hospital, University of<br />
Copenhagen, Copenhagen, Denmark<br />
5167 — B0322 Refractive Development and<br />
Form-Deprivation in Dopamine D4 Receptor<br />
Knock-Out Mice. Han na Park 1 , C. C. Tan 1 , J. G.<br />
Light 1 , F. Aseem 1 , P. M. Iuvone 1, 2 , M. T. Pardue 1, 3 .<br />
1<br />
Ophthalmology, Emory University, Atlanta, GA;<br />
2<br />
Pharmacology, Emory University, Atlanta, GA;<br />
3<br />
Rehabilitation Research & Development Center,<br />
Atlanta Veterans Affairs Medical Center, Decatur,<br />
GA<br />
5168 — B0323 The effect of 2% homatropine<br />
on the choroidal thickness of young healthy<br />
adults. Beata P. Sander, M. J. Collins, S. A. Read.<br />
School of Optometry and Vision Science, QUT,<br />
Kelvin Grove, QLD, Australia<br />
5169 — B0324 In Vivo Crosslinking of Scleral<br />
Collagen in the Rabbit Using Sub-Tenon<br />
Injection of Nitroalcohol. Quan V. Hoang 1, 2 , Q.<br />
Wen 1 , S. Chang 1 , S. L. Trokel 1 , R. H. Silverman 1 , D.<br />
C. Paik 1 . 1 Ophthalmology, Harkness Eye Institute,<br />
Columbia Univ, New York, NY; 2 Vitreous, Retina,<br />
Macula Consultants of New York, New York, NY<br />
*CR<br />
5170 — B0325 Cross-linking of rabbit sclera<br />
using riboflavin and UVA for the prevention of<br />
progressive myopia. Assaf Dotan 1 , I. Kremer 1 , A.<br />
Zigler 2 , D. Bourla 1 . 1 Ophthalmology, Rabin Medical<br />
Center, Petach Tikva, Israel; 2 Racah Institute of<br />
Physics, The Hebrew University, Jerusalem, Israel<br />
5171 — B0326 Vascular endothelial growth<br />
Factor A, C, D and Vascular Endothelial Growth<br />
Factor Receptor 1, 2, 3 mRNA Expression in<br />
the Chicken Retina, RPE and Choroid. Marita<br />
P. Feldkaemper, F. Schaeffel, L. Fuchs. Centre for<br />
Ophthalmology, Institute for Ophthalmic Research,<br />
Tuebingen, Germany<br />
5172 — B0327 Effects of dual-focus, multizone<br />
lenses on refractive development in macaques.<br />
Baskar Arumugam 1, 2 , L. Hung 1, 2 , J. Huang 1, 2 , E.<br />
L. Smith 1, 2 . 1 College of Optometry, University of<br />
Houston, Houston, TX; 2 Vision CRC, Sydney,<br />
NSW, Australia *CR<br />
5173 — B0328 Histo-pathological and<br />
functional degenerative changes of Bruch’s<br />
membrane in form-deprivation myopia in chicks.<br />
Tzyy-Chang Ho. Ophthalmology, National Taiwan<br />
Univ Hospital, Taipei, Taiwan<br />
5174 — B0329 Effect of bright light on<br />
choroidal thickness in chickens as measured<br />
with OCT. Weizhong Lan 1, 2 , M. P. Feldkaemper 1 ,<br />
F. Schaeffel 1 . 1 Section of Neurobiology of the<br />
Eye, Ophthalmic Research Institute, University<br />
of Tuebingen, Tuebingen, Germany; 2 Zhongshan<br />
Ophthalmic Center, Sun Yat-sen University,<br />
Guangzhou, China<br />
5175 — B0330 The efficacy of brief periods of<br />
“vision” in chick eyes wearing negative lenses is<br />
dependent on time of day. Debora L. Nickla, K.<br />
Totonelly. Biosciences, New England College of<br />
Optometry, Boston, MA<br />
5176 — B0331 The effect of two-zone<br />
concentric bifocal lenses on refractive error<br />
and eye shape in guinea pigs. Hannah E.<br />
Bowrey 1 , G. Zeng 1 , A. J. Leotta 1 , C. F. Wildsoet 2 ,<br />
S. A. McFadden 1 . 1 The University of Newcastle,<br />
Callaghan, NSW, Australia; 2 The University of<br />
California, Berkeley, Berkeley, CA<br />
5177 — B0332 Comparing Rates of<br />
Emmetropization and Diurnal Rhythms Before<br />
and After Goggle Removal in Chick. Melanie<br />
C. Campbell 1, 2 , K. Bunghardt 1 , M. L. Kisilak 1, 2 ,<br />
E. L. Irving 2 . 1 Physics & Astronomy, University<br />
of Waterloo, Waterloo, ON, Canada; 2 School of<br />
Optometry and Vision Science, University of<br />
Waterloo, Waterloo, ON, Canada *CR<br />
5178 — B0333 Temporal Frequency Sensitivity<br />
of the Emmetropization Mechanism in Chicks<br />
to Color and Luminance Flicker without Blue<br />
Light. Stephanie Britton, M. Fellows, F. J. Rucker.<br />
Biomedical Science, New England College of<br />
Optometry, Boston, MA<br />
5179 — B0334 The effect of induced<br />
myopia on the scleral creep response of whole<br />
chick eyes. Jacob A. Lewis 1 , M. Garcia 2 , C. F.<br />
Wildsoet 2 . 1 Bioengineering & Materials Science<br />
and Engineering, UC Berkeley, Berkeley, CA;<br />
2<br />
Vision Science, University of California Berkeley,<br />
Berkeley, CA<br />
5180 — B0335 Inhibition in peripheral scleral<br />
lengthening during the development of myopia<br />
in the guinea pig. Guang Zeng, S. A. McFadden.<br />
School of Psychology, the University of Newcastle,<br />
Callaghan, NSW, Australia<br />
5181 — B0336 Luminance variations can<br />
reduce or reverse plus lens compensation in<br />
chicks. Alan G. Busby. Biology, City College of<br />
New York, New York, NY<br />
5182 — B0337 Effects of a human anti-<br />
VEGF antibody (Bevacizumab) on myopia<br />
development and choroidal thickness in the<br />
chicken. Frank Schaeffel 1 , U. Mathis 1 , F. Ziemssen.<br />
1<br />
Section Neurobiology of Eye, Ophthalmic<br />
Research Institute, Tuebingen, Germany; 2 Center<br />
of Ophthalmology, University of Tuebingen,<br />
Tuebingen, Germany *CR<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
330
<strong>Wednesday</strong> – Posters – 5183 – 5204<br />
5183 — B0338 Anti-Diuretic Hormone<br />
Arginine-Vasopressin Promotes an Increased<br />
Myopic Shift in Refractive Compensation to<br />
Optical Defocus in Physiologically Stressful<br />
Environmental Light Conditions. Melanie<br />
J. Murphy 1 , S. G. Crewther 1 , S. N. Kiely 1 , N.<br />
Riddell 1 , L. Giummarra 1 , D. P. Crewther 2 . 1 School<br />
of Psychological Science, La Trobe University,<br />
Melbourne, VIC, Australia; 2 Centre for Human<br />
Psychopharmacology, Swinburne University of<br />
Technology, Melbourne, VIC, Australia<br />
5184 — B0339 The expression of vaoactive<br />
intestinal peptide receptors and ZENK protein<br />
in form-deprivation myopia. Hikmet Basmak 1 ,<br />
H. Gursoy 1 , A. Cakmak 1 , N. Yildirim 1 , N. Tuncel 2 ,<br />
N. Erkasap 2 , M. Ozkurt 2 . 1 Dept of Ophthalmology,<br />
Eskisehir Osmangazi Univ Med Sch, Eskisehir,<br />
Turkey; 2 Physiology, Eskisehir Osmangazi Univ<br />
Med Sch, Eskisehir, Turkey *CR<br />
5185 — B0340 Effects of Adenosine A2A<br />
Receptor on the Development of Form-<br />
Deprivation Myopia in Mice. Jianhong An 1 ,<br />
X. Zhou 1 , F. Shi 1 , J. Chen 1, 2 , J. Qu 1 . 1 School of<br />
Ophthalmology & Optometry, Wenzhou Medical<br />
College, Wenzhou, Zhejiang, China; 2 Department of<br />
Neurology, Boston University School of Medicine,<br />
Boston, MA<br />
5190 — C0005 A Phase I/II Dose-Ranging,<br />
Randomized Clinical Trial of Abatacept<br />
(Orencia) in the Treatment of Refractory<br />
Non-Infectious Uveitis: Preliminary Results.<br />
Eric B. Suhler 1, 2 , T. R. Giles 2 , S. A. Hanel 2 , T. L.<br />
Liesegang 2 , R. M. Beardsley 2 , K. L. Larkin 2 , P. Lin 2 ,<br />
J. T. Rosenbaum 2, 3 . 1 Ophthalmology, Portland VA<br />
Medical Center, Portland, OR; 2 Ophthalmology,<br />
Casey Eye Institute-OHSU, Portland, OR;<br />
3<br />
Ophthalmology, Devers Eye Institute, Portland, OR<br />
*CR, f<br />
5191 — C0006 Effectiveness of anti-Tumor<br />
Necrosis Factor agents in Pediatric Population<br />
with Uveitis. Rula Hajj-ali 1 , M. M. Choudhary 2 ,<br />
A. Zeft 4 , S. Spalding 4 , S. K. Srivastava 3 , C. Y.<br />
Lowder 3 . 1 Orthopedics and Rheumatologic Institute,<br />
Cleveland Clinic Foundation, Cleveland, OH;<br />
2<br />
Internal Medicine, Cleveland Clinic Foundation,<br />
Cleveland, OH; 3 Ophthalmology, Cleveland<br />
Clinic Foundation, Cleveland, OH; 4 Pediatric<br />
Rheumatology, Cleveland Clinic Foundation,<br />
Cleveland, OH *CR<br />
5196 — C0011 Risk Factors Associated with<br />
Intraocular Pressure Rise in Patients with<br />
Uveitis Treated with the Fluocinolone Acetonide<br />
Implant. Anjali Parekh 1 , S. K. Srivastava 2 ,<br />
T. A. Albini 3 , Q. Nguyen 4 , D. A. Goldstein 1 .<br />
1<br />
Ophthalmology, Northwestern Medical Faculty<br />
Foundation, Chicago, IL; 2 Ophthalmology, Cole<br />
Eye Institute, Cleveland, OH; 3 Ophthalmology,<br />
Bascom Palmer Eye Institute, Miami, FL;<br />
4<br />
Ophthalmology, Wilmer Eye Institute, Baltimore,<br />
MD *CR, f<br />
5197 — C0012 Fluocinolone Acetonide<br />
Implants for Refractory Uveitis: a Retrospective<br />
Review. Harpal S. Sandhu, P. Pillai, G. N.<br />
Papaliodis. Ophthalmology, Massachusetts Eye and<br />
Ear Infirmary, Boston, MA<br />
5198 — C0013 Combination chemotherapy<br />
with Mycophenolate mofetil and Cyclosporin<br />
in recalcitrant uveitis. Reena A. Rasheed 1, 2 , G.<br />
T. Markov 1, 3 , C. Foster 1 . 1 Ocular Immunology,<br />
Massachussett’s Eye Research and Surgery<br />
Institution, Massachussetts, MA; 2 Regional Institute<br />
of Ophthalmology, Trivandrum, India; 3 University<br />
Eye Hospital, Pashev, Bulgaria *CR<br />
Exhibit Hall C0001-C0021<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Immunology/Microbiology<br />
473 Non-infectious Inflammation<br />
Moderator: Kazuichi Maruyama<br />
5186 — C0001 Etiology of Non-infectious<br />
Uveitis Following Cataract Surgery. Zvi A.<br />
Kresch 1 , C. Yang 3 , V. Diaz 1 , S. Kedhar 1 , J. V.<br />
Mauro 2 , C. Samson 1 . 1 Ophthalmology, NY Eye and<br />
Ear, New York, NY; 2 North Shore Eye Care, New<br />
York, NY; 3 High School, Newark, NJ *CR<br />
5187 — C0002 Trends in Patterns of<br />
Intermediate Uveitis in a Tertiary Institution in<br />
Singapore. Helen Mi 1 , S. Ho 2 , W. Lim 2 , E. Wong 2 ,<br />
S. C. Teoh 2 . 1 Yong Loo Lin School of Medicine,<br />
National University of Singapore, Singapore,<br />
Singapore; 2 Ophthalmology, National Healthcare<br />
Group Eye Institute, Tan Tock Seng Hospital,<br />
Singapore, Singapore<br />
5188 — C0003 Epidemiology of Infectious<br />
Uveitis in Alabama. Christopher J. Compton,<br />
C. Huisingh, G. McGwin, R. W. Read, K. Beck.<br />
Ophthalmology, Univ of AL - Birmingham,<br />
Birmimgham, AL<br />
5189 — C0004 Characteristics of HLA-B27/<br />
Ankylosing Spondylitis Associated Uveitis in<br />
Different Ethnicities. Russell W. Read 1, 2 , K.<br />
Beck 1 . 1 Ophthalmology, University of Alabama<br />
at Birmingham, Birmingham, AL; 2 Pathology,<br />
University of Alabama at Birmingham,<br />
Birmingham, AL<br />
5192 — C0007 Multicenter study of TNF-a<br />
antagonists for refractory Behçet’s uveitis in<br />
Spain. Marina Mesquida 1 , D. Diaz-Valle 2 , M.<br />
Cordero Coma 3 , A. Fonollosa 4 , V. Llorens 1 , L.<br />
Pelegrin 1 , M. Hernandez 5 , G. Espinosa 6 , B. Molins 1 ,<br />
A. Adan Civera 1 . 1 Ophthalmology, Hospital Clinic<br />
de Barcelona, Barcelona, Spain; 2 Ophthalmology,<br />
Hospital Clinico San Carlos, Madrid, Spain;<br />
3<br />
Ophthalmology, Hospital de León, León, Spain;<br />
4<br />
Ophthalmology, Hospital Universitario Cruces,<br />
Bilbao, Spain; 5 Rheumatology, Hospital Clínic<br />
de Barcelona, Barcelona, Spain; 6 Autoimmune<br />
Disease, Hospital Clínic de Barcelona, Barcelona,<br />
Spain *CR<br />
5193 — C0008 Pharmacological blockade<br />
of interleukin 6 receptor (IL-6R) inhibits the<br />
development of ocular inflammation in the<br />
murine model of experimental autoimmune<br />
uveitis (EAU). Jingtai Cao, T. C. MacPherson, G.<br />
D. Yancopoulos, S. J. Wiegand. Ophthalmology,<br />
Regeneron Pharmaceuticals Inc, Tarrytown, NY<br />
*CR<br />
5194 — C0009 Treatment of Chronic,<br />
Persistent, Non-infectious, Non-granulomatous<br />
Uveitis in Patients with Juvenile Idiopathic<br />
Arthritis. Anton M. Kolomeyer 1 , Y. Tu 1 , N. V.<br />
Nayak 1 , E. Miserocchi 2 , D. S. Chu 1, 3 . 1 Institute of<br />
Ophthalmology and Visual Science, University<br />
of Medicine and Dentistry of NJ, Newark, NJ;<br />
2<br />
Department of Ophthalmology and Visual<br />
Sciences, Scientific Institute San Raffaele,<br />
University Vita-Salute, Milan, Italy; 3 Metropolitan<br />
Eye Research and Surgery Institute, Palisades Park,<br />
NJ *CR<br />
5195 — C0010 Characteristics of patients who<br />
attain remission of inflammatory eye disease<br />
following treatment and discontinuation of<br />
mycophenolate mofetil. Travis Jenkins, T. Truong,<br />
K. Lai, Z. A. Kresch, V. Diaz, J. V. Mauro, S.<br />
Kedhar, C. Samson. Ophthalmology, The New York<br />
Eye and Ear Infirmary, New York, NY *CR<br />
5199 — C0014 Macular thickness<br />
measurements with spectral domain optical<br />
coherence tomography during active episode of<br />
Unilateral Acute Anterior Uveitis. David Diaz-<br />
Valle, S. Garcia-Vidal, P. Arriola-Villalobos, R.<br />
Cuina, J. A. Gegundez-Fernandez, J. M. Benitezdel-Castillo.<br />
Ophthalmology, Hospital Clinico San<br />
Carlos, Madrid, Spain<br />
5200 — C0015 Evolution of intra ocular<br />
inflammation in treated acute anterior uveitis.<br />
Margaux Guillard 1 , E. Perrin 2 , B. Kirwan 2 , D.<br />
Monnet 1 , A. P. Brezin 1 . 1 Ophthalmology, Cochin<br />
Hospital - University Paris Descartes, Paris, France;<br />
2<br />
Socar Research SA, Nyon, Switzerland<br />
5201 — C0016 Use of Immunosuppressive<br />
Medications for Treatment of Pediatric<br />
Intermediate Uveitis. Spencer R. Cope 1 , A. O.<br />
Hersh 1 , A. Shakoor 2 , J. F. Bohnsack 1 , A. T. Vitale 2 .<br />
1<br />
Division of Pediatrics Rheumatology, University<br />
of Utah, Salt Lake City, UT; 2 Ophthalmology and<br />
Visual Sciences, John A. Moran Eye Center, Salt<br />
Lake City, UT *CR<br />
5202 — C0017 Genetic analysis of risk alleles<br />
associated with inflammatory bowel disease<br />
in acute anterior uveitis. Tammy M. Martin, P.<br />
Stauffer, E. Patridge, C. Younkins, M. Burcham, J.<br />
R. Smith. Ophthalmology, Oregon Health & Science<br />
Univ, Portland, OR<br />
5203 — C0018 Optic nerve spectral domain<br />
optical coherence tomography of papillitis<br />
secondary to uveitis. Parvathy Pillai, L. Sobrin.<br />
Ophthalmology, Massachusetts Eye and Ear<br />
Infirmary, Boston, MA<br />
5204 — C0019 Correlation between Disease<br />
Activity and Choroidal Patterns by OCT-EDI in<br />
Birdshot Chorioretinopathy. Andrea D. Birnbaum,<br />
A. A. Fawzi, L. M. Rifkin, D. A. Goldstein.<br />
Ophthalmology, Northwestern Univ Feinberg Sch<br />
of Med, Chicago, IL *CR<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
331
5205– 5228 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
5205 — C0020 Segmentation and Analysis<br />
of Retinal Layers in Eyes with Uveitis and<br />
Comparison with Normal. Syed Mahmood A.<br />
Shah, Y. J. Sepah, M. A. Sadiq, S. Kherani, M.<br />
A. Ibrahim, Z. S. Rentiya, M. Ansari, D. V. Do,<br />
Q. Nguyen. Wilmer Eye Institute, Johns Hopkins<br />
University, Baltimore, MD *CR<br />
5206 — C0021 Predictive Value of Angiotensin<br />
Converting Enzyme, Soluble Interleukin-2<br />
Receptor and Lysozyme for Pulmonary<br />
Involvement in Human Ocular Sarcoidosis.<br />
Rafael Grajewski 1 , W. Adler 2 , K. Frank 3 , M.<br />
Arfaoui 1 , S. L. Schlereth 1 , B. Kirchhof 1 , C.<br />
Cursiefen 1 , L. M. Heindl 1 . 1 Ophthalmology,<br />
University of Cologne, Cologne, Germany;<br />
2<br />
Medical Informatics, Biometry and Epidemiology,<br />
Friedrich-Alexander University Erlangen-Nürnberg,<br />
Erlangen, Germany; 3 Internal Medicine III,<br />
University of Cologne, Cologne, Germany *CR<br />
Exhibit Hall C0126-C0141<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Immunology/Microbiology<br />
474 Corneal Infection/Inflammation I<br />
Moderator: Robert M. Shanks<br />
5207 — C0126 MyD88-dependent and<br />
-independent antimicrobial activity in mouse<br />
corneas induced by Pseudomonas aeruginosa<br />
antigen challenge. Suzanne M. Fleiszig, D. J.<br />
Evans, C. Tam. School of Optometry, Univ of<br />
California - Berkeley, Berkeley, CA *CR<br />
5208 — C0127 An Experimental Model<br />
of Biofilm Formation in the Mouse Cornea.<br />
Padmanabhan Saraswathi, T. T. Aung, S. Salleh, R.<br />
W. Beuerman. Singapore Eye Research Institute,<br />
Singapore, Singapore *CR<br />
5209 — C0128 The role of autophagy in<br />
Pseudomonas aeruginosa keratitis. Xiaoyu Jiang,<br />
S. A. McClellan, R. P. Barrett, Y. Zhang, M. E.<br />
Foldenauer, K. Vistisen, L. D. Hazlett. Department<br />
of Anatomy and Cell Biology, Wayne State<br />
University School of Medicine, Detroit, MI<br />
5210 — C0129 Toll-like receptor 4: A regulator<br />
of apoptosis in the infected cornea. Sharon A.<br />
McClellan, X. Jiang, Y. Zhang, K. Vistisen, R. P.<br />
Barrett, L. D. Hazlett. Anatomy & Cell Biology,<br />
Wayne State Univ School of Med, Detroit, MI<br />
5211 — C0130 Galectin-1-Mediated<br />
Suppression of Th17 Cell-Induced Corneal<br />
Immunopathology post Pseudomonas aeruginosa<br />
Infection. Amol Suryawanshi 1 , Z. Cao 1 , T. S. Zaidi 2 ,<br />
N. A. Panjwani 1 . 1 New England Eye Center and<br />
Department of Ophthalmology, Tufts University<br />
School of Medicine, Boston, MA; 2 Department of<br />
Medicine, Brigham and Women’s Hospital, Boston,<br />
MA<br />
5212 — C0131 In Vivo Efficacy of Keratin-<br />
Derived Antimicrobial Peptides (KDAMPs)<br />
in Corneal Defense Against Pseudomonas<br />
aeruginosa. Connie Tam. School of Optometry,<br />
Univ of California, Berkeley, Berkeley, CA *CR<br />
5213 — C0132 Proteomic Analysis of the<br />
Keratitis Associated Pseudomonas aeruginosa.<br />
Abby L. Sewell, J. J. Dunmire, M. Wehmann, R.<br />
Bouhenni. Ophthalmology Research, Summa Health<br />
System, Akron, OH<br />
5214 — C0133 Pseudomonas aeruginosa uses<br />
type three secretion-dependent and -independent<br />
mechanisms for traversal of multilayered corneal<br />
epithelia. Aaron B. Sullivan 1 , V. Hritonenko 1 , C.<br />
Tam 1 , D. J. Evans 2 , S. M. Fleiszig 1 . 1 School of<br />
Optometry, UC Berkeley, Berkeley, CA; 2 College<br />
of Pharmacy, Turo University- California, Vellejo,<br />
CA *CR<br />
5215 — C0134 ExoS, a type III secreted toxin,<br />
is produced intracellularly by P. aeruginosa after<br />
corneal epithelial cell invasion, and is triggered<br />
by exposure to cell lysates. Victoria Hritonenko 1 ,<br />
A. L. Jolly 1 , C. Maloney 2 , A. Farfel 3 , D. J. Evans 1, 4 ,<br />
S. M. Fleiszig 1 . 1 School of Optometry, University of<br />
California, Berkeley, CA; 2 Dept. of Environmental<br />
Science, Policy, and Management, University of<br />
California, Berkeley, AR; 3 Dept. of Molecular &<br />
Cell Biology, University of California, Berkeley,<br />
CA; 4 College of Pharmacy, Touro University<br />
California, Vallejo, CA *CR<br />
5216 — C0135 VIP Treatment of Bacterial<br />
Keratitis Against Multiple Pseudomonas Strains.<br />
Elizabeth A. Berger, L. D. Hazlett. Anatomy & Cell<br />
Biology, Wayne State Univ Sch of Med, Detroit, MI<br />
5217 — C0136 IL-1R and TLR-5 mediate<br />
corneal epithelial defense against Pseudomonas<br />
aeruginosa colonization and traversal<br />
respectively. David J. Evans 1, 2 , C. Tam 2 , S. M.<br />
Fleiszig 2 . 1 College of Pharmacy, Touro University<br />
California, Vallejo, CA; 2 School of Optometry, UC<br />
Berkeley, Berkeley, CA *CR<br />
5218 — C0137 Microbiological and electron<br />
microscopic assessment of Pseudomonas<br />
aeruginosa infection of primary human corneal<br />
fibroblasts and epithelial cells in-vitro. Ahmad<br />
Elsahn 1, 2 , P. Hossain 2, 1 , M. Christodoulides 1 .<br />
1<br />
Molecular Microbiology, University of<br />
Southampton, Southampton, United Kingdom;<br />
2<br />
Southampton Eye Unit, University Hospitals<br />
Southampton NHS Foundation Trust, Southampton,<br />
United Kingdom<br />
5219 — C0138 Cystic Fibrosis Transmembrane<br />
conductance Regulator (CFTR) competes with<br />
Pseudomonas aeruginosa Type 3 Secretion<br />
System (T3SS) to direct the fate of intracellular<br />
bacteria. Amber L. Jolly 1 , S. A. Whiteside 1 , D. J.<br />
Evans 2, 1 , S. M. Fleiszig 1 . 1 Vision Sciences, UC<br />
Berkeley, Berkeley, CA; 2 College of Pharmacy,<br />
Touro University, Vallejo, CA *CR<br />
5220 — C0139 Impediment of corneal cell<br />
migration by a Serratia marcescens factor in an<br />
in vitro wound healing model. Kimberly Brothers,<br />
N. A. Stella, J. Klarlund, R. M. Shanks. University<br />
of Pittsburgh, Pittsburgh, PA *CR<br />
5221 — C0140 Isolation of Two Proteases<br />
from Streptococcus pneumoniae that Cause<br />
Corneal Erosions. Mary E. Marquart, S. D.<br />
Taylor. Microbiology, Univ of Mississippi Med Ctr,<br />
Jackson, MS<br />
5222 — C0141 Genomics of the Conjunctival<br />
Pathogen Streptococcus pneumoniae. Michael<br />
Valentino 1 , W. Haas 2 , C. M. Sanfilippo 2 , J. W.<br />
Rosch 3 , E. I. Tuomanen 3 , T. W. Morris 2 , M. S.<br />
Gilmore 1 . 1 Harvard Medical School / Mass. Eye<br />
& Ear Infirmary, Boston, MA; 2 Bausch & Lomb,<br />
Inc., Rochester, NY; 3 St. Jude Children’s Research<br />
Hospital, Memphis, TN *CR<br />
Exhibit Hall C0142-C0156<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Cornea / Biochemistry/Molecular Biology<br />
475 Corneal Wound Repair,<br />
Transparency II<br />
Moderator: Shizuya Saika<br />
5223 — C0142 MicroRNA signature in wound<br />
healing following excimer laser ablation:<br />
Role of miR-133b on TGF- β, CTGF, collagen<br />
and smooth muscle actin synthesis in corneal<br />
fibroblast. Paulette M. Robinson 1, 2 , T. Chuang 1 , S.<br />
Sriram 1 , L. Pi 1 , X. Luo 1 , B. Petersen 2 , G. S. Schultz 1 .<br />
1<br />
OB-GYN, University of Florida, Gainesville, FL;<br />
2<br />
Pediatrics, University of Florida, Gainesville, FL<br />
5224 — C0143 Long-term visual outcomes<br />
in the Steroids for Corneal Ulcers Trial. Scott<br />
M. McClintic 1 , S. M. McClintic 1 , N. V. Prajna 2 ,<br />
M. Srinivasan 2 , J. Mascarenhas 2 , L. Prajna 2 ,<br />
T. Porco 1, 3 , N. Acharya 1, 3 , T. M. Lietman 1, 3 , J.<br />
D. Keenan 1, 3 . 1 Ophthalmology, University of<br />
California, San Francisco, San Francisco, CA;<br />
2<br />
Cornea and External Diseases, Aravind Eye Care<br />
System, Madurai, India, Madurai, India; 3 Francis I.<br />
Proctor Foundation, University of California, San<br />
Francisco, San Francisco, CA *CR<br />
5225 — C0144 The Effect of Local Rock-<br />
Inhibition on Corneal Scarring After Alkali<br />
Burn Injury. Davine Sijnave 1 , K. P. Hollanders 1 ,<br />
T. Van Bergen 1 , S. Van de Velde 1 , E. Vandewalle 1 ,<br />
L. K. Moons 2 , D. Leysen 3 , I. Stalmans 1 . 1 Lab of<br />
Ophthalmology, KULeuven, Leuven, Belgium;<br />
2<br />
Department of Biology, KULeuven, Leuven,<br />
Belgium; 3 Amakem Therapeutics, Diepenbeek,<br />
Belgium *CR<br />
5226 — C0145 Abnormal epithelial basement<br />
membrane ultrastructure in corneas with haze<br />
after PRK in rabbits. Andre A. Torricelli 1, 2 , V.<br />
Singh 1 , V. Agrawal 1 , S. E. Wilson 1 . 1 Ophthalmology,<br />
Cleveland Clinic, Cleveland, OH; 2 Ophthalmology,<br />
FMUSP, Sao Paulo, Brazil *CR<br />
5227 — C0146 Substance P potentiates<br />
Anti-Fas induced apoptosis in human corneal<br />
fibroblasts. Peter Boman 1, 2 , S. Le Roux 1 , P.<br />
Danielson 1, 2 . 1 Anatomy, Umeå University, Umeå,<br />
Sweden; 2 Dept. of Clinical Science, Ophthalmology,<br />
Umeå Univeristy, Umeå, Sweden<br />
5228 — C0147 TGF-β1 modulates the<br />
functional expression of the NK-1 receptor in<br />
human corneal fibroblasts. Sandrine LE ROUX, P.<br />
Boman, P. Danielson. Anatomy, Dept. of Integrative<br />
Medical Biology, Anatomy, Umeå University,<br />
Umeå, Sweden<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
332
<strong>Wednesday</strong> – Posters – 5229 – 5251<br />
5229 — C0148 A Long-Lasting Scar in Murine<br />
Cornea. Andrew Hertsenberg, S. Basu, Y. Du, J.<br />
L. Funderburgh. Ophthalmology, University of<br />
Pittsburgh School of Medicine, Pittsburgh, PA<br />
5230 — C0149 Autologous Platelet Rich<br />
Plasma Therapy in Resistant Corneal Ulcers.<br />
Yakup Aksoy 1 , U. Erdem 2 . 1 Ophthalmology, Gülhane<br />
Military Medical Academy Haydarpasa Education<br />
Hospital, istanbul, Turkey; 2 Ophthalmology,<br />
Gülhane Military Medical Faculty, Ankara, Turkey<br />
5231 — C0150 Initial Evidence that Immune<br />
Cell Infiltrates are Candidate Sources of Post-<br />
Surface Ablation Stromal Roughening. Daniel J.<br />
Gibson, G. S. Schultz. Obstetrics and Gynecology,<br />
University of Florida, Gainesville, FL<br />
5232 — C0151 Outcomes of Traumatic<br />
Dehiscence of Penetrating Keratoplasty versus<br />
Severe Open-Globe Injury. Therese Peron,<br />
M. A. Woodward, R. M. Shtein. Department of<br />
Ophthalmology, University of Michigan, Ann<br />
Arbor, MI<br />
5233 — C0152 Proteomic analysis of the<br />
interaction Fusarium solani - Staphylococcus<br />
epidermidis isolated from human corneal<br />
ulcers. Mariana Ortiz-Casas 1 , A. V. Rodríguez-<br />
Tovar 2 , J. Reyes-Grajeda 3 , H. Mejia-Lopez 1 , M.<br />
A. Martínez-Rivera 2 , L. A. Bautista-Hernández 1 ,<br />
C. Gaona-Juárez 1 , N. López-Espinosa 1 , V. M.<br />
Bautista 1 . 1 Microbiology and Proteomics, Institute<br />
of Opthalmology “Conde de Valenciana”, Mexico<br />
City, Mexico; 2 Medical Mycology, Escuela<br />
Nacional de Ciencias Biológicas, IPN, Mexico<br />
City, Mexico; 3 Medical Proteomics Unit, Instituto<br />
Nacional de Medicina Genómica, Mexico City,<br />
Mexico<br />
5234 — C0153 Collagen vitrigels for cornea<br />
reconstruction: collagen source and crosslinking.<br />
Shoumyo Majumdar 1, 2 , M. Garza-Madrid 2, 3 , X.<br />
Calderon-Colon 4 , M. Trexler 4 , O. D. Schein 5 ,<br />
J. Elisseeff 1, 2 . 1 Biomedical Engineering, Johns<br />
Hopkins University, Baltimore, MD; 2 Translational<br />
Tissue Engineering Center, Wilmer Eye Institute,<br />
Johns Hopkins School of Medicine, Baltimore,<br />
MD; 3 Ophthalmology and Visual Sciences<br />
Research Chair, School of Medicine and Health<br />
Sciences, Tecnológico de Monterrey, Monterrey,<br />
Mexico; 4 Applied Physics Laboratory, Johns<br />
Hopkins University, Laurel, MD; 5 Department<br />
of Ophthalmology, Wilmer Eye Institute, Johns<br />
Hopkins School of Medicine, Baltimore, MD *CR<br />
5235 — C0154 A Role for Macrophage-derived<br />
Interleukin-20 in Mouse Corneal Epithelial<br />
Wound Healing. Wanyu Zhang 1 , C. W. Smith 2 ,<br />
Z. Li 2 , A. R. Burns 1, 2 . 1 College of Optometry,<br />
University of Houston, Houston, TX; 2 Pediatricsleukocyte<br />
biology, Baylor College of Medicine,<br />
Houston, TX<br />
5236 — C0155 The Effects of Amniotic<br />
Membrane Extract on Primary Human Corneal<br />
Epithelial Cells. David V. Dudok 1 , K. Cheung 1 ,<br />
H. Liu 1 , L. Vedovelli 3 , E. Ghinelli 2 , K. Kenyon 2 ,<br />
S. Parapuram 1 , C. M. Hutnik 1 . 1 Ophthalmology,<br />
Western University Canada, London, ON, Canada;<br />
2<br />
Ophthalmology, Massachusetts Eye & Ear<br />
Infirmary, Boston, MA; 3 Division of Nephrology,<br />
Cell Biology, Human Biology and Physiology,<br />
Massachusetts General Hospital, Boston, MA<br />
5237 — C0156 Sex-Specific Differences in the<br />
Corneal Inflammatory Reparative Response via<br />
Estrogen Modulation of Phagocytosis. Samantha<br />
B. Wang, K. M. Hu, Y. Wang, D. W. Lin, J. Jong,<br />
J. Lai, K. Gronert. Vision Science Program,<br />
University of California, Berkeley, Oakland, CA<br />
Exhibit Hall C0157-C0177<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Cornea<br />
476 Corneal Stroma and Keratocytes<br />
Moderator: Holly B. Hindman<br />
5238 — C0157 Keratocyte-Keratocyte<br />
Translamellar Connectivity in the Mouse Cornea<br />
is Revealed using a Novel 3-D Ultrastructural<br />
Approach. Samuel D. Hanlon 1 , N. C. Shenoi 1 ,<br />
P. T. Harris 1 , P. T. Landry 1 , A. R. Behzad 2 , E. S.<br />
Brown 1 , M. M. Gondo 1 , A. R. Burns 1, 3 . 1 Research,<br />
Univ of Houston College of Optometry, Houston,<br />
TX; 2 Imaging and Characterization Core Lab, King<br />
Abdullah University of Science and Technology,<br />
Thuwal, Saudi Arabia; 3 Leukocyte Biology, Baylor<br />
College of Medicine, Houston, TX<br />
5239 — C0158 Effect of Serum Clot Activator<br />
on Keratocytes. Ji-Eun Lee 1 , S. Lee 2 , J. Lee 1 .<br />
1<br />
Ophthalmology, Pusan National University,<br />
Pusan, Republic of Korea; 2 Ophthalmology, Kosin<br />
University, Pusan, Republic of Korea<br />
5240 — C0159 Co-cultures of Human Corneal<br />
Epithelium and Self-assembled Keratocyte<br />
and Fibroblast Matrix. Audrey E. Hutcheon 1, 2 ,<br />
D. Karamichos 1, 2 , X. Q. Guo 1, 2 , J. D. Zieske 1, 2 .<br />
1<br />
Schepens Eye Research Institute/MEE, Boston,<br />
MA; 2 Department of Ophthalmology, Harvard<br />
Medical School, Boston, MA<br />
5241 — C0160 RNAi Gene Silencing Of TGFbeta<br />
Signaling: A Powerful Approach To Control<br />
Corneal Fibrosis. Jason T. Rodier, A. Sharma,<br />
A. Tandon, A. Stallard, R. R. Mohan. Mason<br />
Eye Institute, University of Missouri-Columbia,<br />
Columbia, MO<br />
5242 — C0161 Up-Regulation of Apoptotic<br />
Markers Following β-Actin Gene-Silencing<br />
in Corneal Stromal Fibroblasts. Roy Joseph 1 ,<br />
O. P. Srivastava 1 , R. R. Pfister 2 . 1 Department of<br />
Vision Sciences, Univ of Alabama at Birmingham,<br />
Birmingham, AL; 2 Eye Research Foundation,<br />
Birmingham, AL<br />
5243 — C0162 Collective Spreading and<br />
Migration of Corneal Fibroblasts in Fibrin<br />
Matrices are not Dependent on Increased Cell<br />
Contractility. Miguel Miron Mendoza, M. Petroll.<br />
Ophthalmology, Univ of Texas Southwestern Med<br />
Ctr, Dallas, TX<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
333<br />
5244 — C0163 Alarmin from corneal epithelial<br />
cells synergizes with Th2 cytokines on the<br />
expression of CCL11 and VCAM-1 by corneal<br />
fibroblasts. Ken Fukuda 1 , H. Tanaka 2 , W. Ishida 1 ,<br />
Y. Harada 1 , T. Sumi 1 , A. Matsuda 3 , N. Ebihara 3 ,<br />
A. Fukushima 1 . 1 Ophthalmology, Kochi Medical<br />
School, Nankoku, Japan; 2 Ophthalmology, Machida<br />
Hospital, Kochi, Japan; 3 Ophthalmology, Juntendo<br />
University School of Medicine, Tokyo, Japan *CR<br />
5245 — C0164 Mitomycin C Suppresses<br />
Gene Splicing in Corneal Fibroblasts. Tsan-Chi<br />
Chen 1 , S. Chang 1, 2 , C. Lee 1 , H. Teng 1 . 1 Department<br />
of Ophthalmology, Far Eastern Memorial<br />
Hospital, New Taipei City, Taiwan; 2 Department<br />
of Ophthalmology, National Taiwan University<br />
Hospital, Taipei, Taiwan f<br />
5246 — C0165 The anti-fibrotic Halofuginone<br />
regulates the expression of Egr-1 in human<br />
corneal fibroblasts. Ching Yuan, M. Twite, E. F.<br />
Nelson. Ophthalmology and Visual Neurosciences,<br />
University of Minnesota, Minneapolis, MN<br />
5247 — C0166 Effect of TGF-β1 and 3 on<br />
protein expression in human corneal fibroblasts.<br />
Xiaoqing Q. Guo 1, 2 , A. E. Hutcheon 1, 2 , J. D.<br />
Zieske 1, 2 . 1 Schepens Eye Research Institute/MEE,<br />
Boston, MA; 2 Department of Ophthalmology,<br />
Harvard Medical School, Boston, MA<br />
5248 — C0167 Thrombin regulates Cyr61<br />
synthesis and processing in cultured human<br />
corneal stromal fibroblasts and myofibroblasts.<br />
Emily A. Andreae 1 , D. J. Warejcka 1 , S. S. Twining 2 .<br />
1<br />
Biochemistry, The Medical College of Wisconsin,<br />
Milwaukee, WI; 2 Biochemistry and Ophthalmology,<br />
The Medical College of Wisconsin, Milwaukee, WI<br />
5249 — C0168 Trichostatin A inihibits TGFβ-induced<br />
reactive oxygen species accumulation<br />
and myofibroblast differentiation via enhanced<br />
Nrf2-ARE signaling. Qingjun Zhou, L. Yang, M.<br />
Qu. Shandong Eye Institute, Qingdao, China<br />
5250 — C0169 Exploring cell plasticity: the<br />
corneal keratocyte and beyond. Carol A. Greene,<br />
T. Sherwin, C. R. Green. Ophthalmology, University<br />
of Auckland, Auckland, New Zealand<br />
5251 — C0170 Reprogramming Genes Are<br />
Expressed during Spheroidal Culture of Corneal<br />
Stromal Cells. Yong-Soo Byun, L. Yco, B. Shaheen,<br />
A. Sharma, S. Chaudhary, S. Gandhi, S. H. Jassim,<br />
J. Sarkar, S. Tibrewal, S. Jain. Ophthalmology and<br />
Visual Sciences, University of Illinois at Chicago,<br />
Chicago, IL *CR<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm
5252 – 5276 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
5252 — C0171 Tissue-engineered corneal<br />
stromal substitutes transplanted in the living<br />
feline model: biocompatibility, ultrastructure<br />
and performance. Marie Boulze Pankert 1, 2 , B.<br />
Goyer 3 , M. Bareille 2 , K. Singh 2 , S. Proulx 3, 5 , I.<br />
Brunette 2, 4 . 1 Departement d’ophtalmologie, Centre<br />
Hospitalier Universitaire de l’Université de la<br />
Mediterranée, Marseille, France; 2 Maisonneuve-<br />
Rosemont Hospital Research Center, Montreal, QC,<br />
Canada; 3 Centre LOEX de l’Université Laval, Génie<br />
tissulaire et régénération - Centre de recherche<br />
FRQS du Centre Hospitalier Universitaire, Quebec,<br />
QC, Canada; 4 Department of Ophthalmology,<br />
University of Montreal, Montreal, QC, Canada;<br />
5<br />
Département d’ophtalmologie et d’oto-rhinolaryngologie,<br />
Faculté de médecine, Université<br />
Laval, Quebec, QC, Canada<br />
5253 — C0172 Reinnervation of corneal<br />
stroma reconstructed by tissue engineering<br />
transplanted in the living feline model. Fatma<br />
Zaguia 1 , M. Boulze Pankert 2, 1 , B. Goyer 3 , S.<br />
Proulx 3, 5 , I. Brunette 1, 4 . 1 Hopital Maisonneuve<br />
Rosemont, Montreal, QC, Canada; 2 Université<br />
de la Mediterranée, Marseille, France; 3 Centre<br />
de recherche FRSQ de Centre hospitalier affilié<br />
universitaire du quebec- Universite Laval, Quebec,<br />
QC, Canada; 4 Université de Montréal, Montreal,<br />
QC, Canada; 5 Université Laval, Montreal, QC,<br />
Canada<br />
5254 — C0173 A stromal corneal nerves<br />
analysis in type 2 diabetic patients by confocal<br />
microscopy. Manuel Ramirez, E. Hernandez-<br />
Quintela. Cornea, APEC, Mexico City, Mexico<br />
5255 — C0174 Interclass Synergistic Effects of<br />
Small Leucine-Rich Proteoglycans in Regulating<br />
Collagen Fibrillogenesis During Corneal<br />
Development. Shoujun Chen 1 , S. Chakravarti 2 , D.<br />
E. Birk 1 . 1 Department of Molecular Pharmacology<br />
and Physiology, University of South Florida,<br />
Tampa, FL; 2 Department of Medicine, Johns<br />
Hopkins University, Baltimore, MD<br />
5256 — C0175 Collagen XII regulates<br />
collagen fibril packing, lamellar organization,<br />
stromal architecture and corneal function.<br />
Chinda Hemmavanh 1 , E. M. Espana 1, 2 , D. E.<br />
Birk 1 . 1 Molecular Pharmacology and Physiology,<br />
USF Morsani College of Medicine, Tampa, FL;<br />
2<br />
Ophthalmology, University of South Florida,<br />
Tampa, FL<br />
5257 — C0176 Extracellular matrix<br />
characterization of the acellular gammairradiated<br />
cornea. Jemin J. Chae 1 , J. S. Choi 1 ,<br />
W. Stark 2 , J. Elisseeff 1 . 1 Biomedical Engineering,<br />
Johns Hopkins University, Baltimore, MD;<br />
2<br />
Ophthalmology, Johns Hopkins University,<br />
Baltimore, MD *CR<br />
5258 — C0177 Structural changes in the<br />
anterior corneal stroma of bullous keratopathy<br />
patients after endothelial keratoplasty. Naoyuki<br />
Morishige, Y. Morita, N. Yamada, K. Sonoda. Dept<br />
of Ophthalmology, Yamaguchi Univ Grad Sch of<br />
Med, Ube, Japan<br />
Exhibit Hall C0178-C0224<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Cornea<br />
477 Corneal Cross-linking and<br />
Keratoconus<br />
Moderator: Shameema Sikder<br />
5259 — C0178 MDV1224 A New Riboflavin<br />
Formulation for Trans-Epithelial Cross-Linking.<br />
Sergio Mangiafico, D. Aleo. R&D, Medivis,<br />
Catania, Italy *CR<br />
5260 — C0179 Corneal sensitivity changes<br />
following cross-linking for progressive lower<br />
stage keratoconus. Belquiz A. Nassaralla 1 , A. M.<br />
Lago 1 , L. S. Stival 1 , J. J. Nassaralla 2 . 1 Cataract<br />
Cornea & Refractive Surgery, Instituto de Olhos<br />
de Goiania, Goiania, Brazil; 2 Retina and Vitreous,<br />
Instituto de Olhos de Goiania, Goiania, Brazil f<br />
5261 — C0180 Impact of corneal cross-linking<br />
on drug penetration in humans. Christoph<br />
Tappeiner, M. Tschopp, K. Schuerch, B. E. Frueh.<br />
Department of Ophthalmology, Inselspital,<br />
University Hospital of Bern, Bern, Switzerland<br />
5262 — C0181 Apparent progression in<br />
children after corneal cross-linking for<br />
keratoconus. Beatrice E. Frueh, C. Tappeiner.<br />
Ophthalmology, Univ of Bern Inselspital, Bern,<br />
Switzerland<br />
5263 — C0182 Corneal Endothelial Cell<br />
Density Following Transepithelial Collagen<br />
Cross-Linking. Michael W. Raciti 1 , R. J. Epstein 1, 2 ,<br />
P. Majmudar 1, 2 , W. Trattler 3 . 1 Rush University<br />
Medical Center, Chicago, IL; 2 Chicago Cornea<br />
Consultants, Chicago, IL; 3 Center For Excellence In<br />
Eye Care, Miami, FL *CR<br />
5264 — C0183 Concurrent vs Sequential<br />
Corneal Collagen Crosslinking and Intacs ®<br />
for Keratoconus and Corneal Ectasia. Steven<br />
A. Greenstein 1, 2 , P. S. Hersh 2, 1 . 1 Ophthalmology,<br />
UMDNJ - New Jersey Medical School, Newark,<br />
NJ; 2 Cornea and Laser Eye Institute - Hersh Vision<br />
Group, Teaneck, NJ *CR, f<br />
5265 — C0184 A new constant-force technique<br />
to measure corneal biomechanical changes after<br />
corneal collagen cross-linking. David Tabibian 1 ,<br />
O. Richoz 1 , E. Spoerl 3 , A. Hammer 1 , F. Hoogewoud 1 ,<br />
F. Hafezi 1, 2 . 1 Ophthalmology, Geneva University<br />
Hospital, Geneva, Switzerland; 2 Ophthalmology,<br />
Doheny Eye institute, Keck School of Medicine<br />
USC, Los Angeles, CA; 3 Ophthalmology,<br />
University Hospital Dresden, Dresden, Germany<br />
*CR<br />
5266 — C0185 Corneal collagen crosslinking<br />
in young patients: One-year results. Marcony<br />
R. Santhiago 2, 1 , M. L. Monteiro 1 , H. Moraes 1 ,<br />
R. Espindola 1 , R. C. Ghanem 1 , M. Netto 1 .<br />
1<br />
Ophthalmology, Federal University of Rio de<br />
Janeiro, Rio de Janeiro, Brazil; 2 Cataract and<br />
Refractive Surgery - Ophthalmology, Federal<br />
University of Rio de Janeiro, Rio de Janeiro, Brazil<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
334<br />
5267 — C0186 Two-year results of corneal<br />
cross-linking in pediatric patients with<br />
progressive keratoconus. Dan Epstein 1 , B. E.<br />
Frueh 2 , E. Albé 3 , P. Vinciguerra 3 . 1 Ophthalmology,<br />
Research Institute, Bern, Switzerland;<br />
2<br />
Ophthalmology, University of Bern, Inselspital,<br />
Bern, Switzerland; 3 Ophthalmology, Istituto clinico<br />
Humanitas, Milan, Italy *CR<br />
5268 — C0187 Fluorescein Competes<br />
Riboflavin in CXL (Corneal Collagen Cross-<br />
Linking) for the Treatment of Infectious<br />
Keratitis. Farhad Hafezi 1, 2 , Z. Gatzioufas 1 ,<br />
A. Hammer 1 , D. Tabibian 1 , O. Richoz 1 .<br />
1<br />
Ophthalmology, Geneva University Hospitals,<br />
Geneva, Switzerland; 2 Ophthalmology, Doheny<br />
Eye Institute, Keck School of Medicine USC, Los<br />
Angeles, CA *CR<br />
5269 — C0188 In Vivo Ultrasound-enhanced<br />
Penetration Of Topical Riboflavin Into The<br />
Corneal Stroma. Ricardo Lamy, E. Chan, H.<br />
Zhang, V. Salgaonkar, C. J. Diederich, J. M.<br />
Stewart. Ophthalmology, University of California,<br />
San Francisco, San Francisco, CA<br />
5270 — C0189 Combining Iontophoresis and<br />
corneal collagen crosslinking: a basic science<br />
study on human corneas. Rita Mencucci, I.<br />
Paladini, E. Favuzza, U. Menchini, M. Marini, E.<br />
Sarchielli, B. Vannelli. Ophthalmology, Eye Clinic<br />
University of Florence, Firenze, Italy<br />
5271 — C0190 Accelerated cross-linking in<br />
patients with keratoconus: 6 months follow-up.<br />
Johnny Javier Castellar Cerpa, J. Peraza Nieves, R.<br />
Cuiña Sardiña, D. Diaz-Valle, R. Mendez, J. García<br />
Bella, J. Fernández-Vigo, J. M. Benitez-del-Castillo.<br />
Ophthalmology, Hospital Clinco San Carlos,<br />
Madrid, Spain<br />
5272 — C0191 Corneal Deformation<br />
Characteristics and IOP before and after<br />
Collagen Crosslinking. Cynthia J. Roberts, A.<br />
M. Mahmoud, R. G. Lembach, T. F. Mauger.<br />
Department of Ophthalmology and Department of<br />
Biomedical Engineering, The Ohio State University,<br />
Columbus, OH *CR, f<br />
5273 — C0192 Results of cross-linking in<br />
keratoconic corneas on visual function. One<br />
year follow-up. Ricardo Cuina, J. Vazquez-<br />
Molini, D. Diaz-Valle, J. M. Benitez-del-Castillo.<br />
Oftalmología, Hospital Clínico San Carlos, Madrid,<br />
Spain<br />
5274 — C0193 Impact of Riboflavin<br />
Formulations on Corneal Hydration. Evan A.<br />
Sherr, P. Kamaev, S. Rood-Ojalvo, M. D. Friedman,<br />
D. Muller. Avedro, Inc, Waltham, MA *CR<br />
5275 — C0194 Assessment the long term effect<br />
of corneal cross-linking therapy on corneal<br />
ectasia in progressive keratoconus. Illes Kovacs,<br />
K. Kranitz, A. Gyenes, G. L. Sándor, E. Juhasz,<br />
L. Dienes, J. Nemeth, Z. Z. Nagy. Department of<br />
Ophthalmology, Semmelweis University, Budapest,<br />
Hungary *CR<br />
5276 — C0195 Use of Zonal Km vs Point Kmax<br />
for Analysis of Corneal Cross-linking Pentacam<br />
Topography. Grace Lytle 1 , M. D. Friedman 1 , P. S.<br />
Hersh 2 , D. Muller 1 . 1 Avedro Inc, Waltham, MA;<br />
2<br />
Hersh Vision Group, Cornea and LASER EYE<br />
Institute, Teaneck, NJ *CR
<strong>Wednesday</strong> – Posters – 5277 – 5302<br />
5277 — C0196 Evaluation of corneal flattening<br />
in progressive keratoconus with Scheimpflug<br />
imaging. Kinga Kranitz, I. Kovacs, A. Gyenes, G.<br />
L. Sándor, E. Juhasz, L. Dienes, J. Nemeth, Z. Z.<br />
Nagy. Department of Ophthalmology, Semmelweis<br />
University, Budapest, Hungary *CR<br />
5278 — C0197 Corneal Collagen Crosslinking<br />
in Keratoconic Eyes at Different Stages. Nurullah<br />
Cagil, O. Sarac, E. Akcay, N. Ugurlu, E. Can,<br />
G. Can. Department of Ophthalmology, Yildirim<br />
Beyazit University, Ankara, Turkey<br />
5279 — C0198 Shorter UVA Light Exposure<br />
Protocol for Crosslinking in Keratoconus in<br />
Children Without Progression Criteria. Andres<br />
Codriansky 1, 2 , M. Aravena 1, 2 , M. Coria 1, 2 . 1 Cornea<br />
and Refractive Surgery, Hospital Sotero del Rio /<br />
IOPA, Santiago, Chile; 2 Cataract Surgery, Hospital<br />
Sotero del Rio, Santiago, Chile<br />
5280 — C0199 Papain Digestion Method for<br />
Analysis of Cross-linking in Corneal Flaps. Sara<br />
Rood-Ojalvo, P. Kamaev, M. D. Friedman, D.<br />
Muller. Avedro Inc., Waltham, MA *CR<br />
5281 — C0200 Accelerated UVA-RF Corneal<br />
Cross-linking through Pulsed UVA Illumination<br />
and Oxygen Rich Environments. David Muller,<br />
P. Kamaev, M. D. Friedman, E. A. Sherr, W. A.<br />
Eddington. Avedro, Waltham, MA *CR<br />
5282 — C0201 Topical alternatives to<br />
therapeutic riboflavin photochemical tissue<br />
cross-linking: a comparison of cell toxicity<br />
thresholds. Mi Jung Kim, Q. Wen, Q. V. Hoang, S.<br />
L. Trokel, D. C. Paik. Ophthalmology, Columbia<br />
University, College of Physicains and Surgeons,<br />
New York, NY *CR, f<br />
5283 — C0202 Corneal Thickness Changes<br />
during Collagen Crosslinking using Riboflavin/<br />
Dextran or Hypotonic Riboflavin. Elan A.<br />
Rosenblat 1, 2 , A. L. Sachs 2 , S. A. Greenstein 1, 2 , P. S.<br />
Hersh 2, 1 . 1 Department of Ophthalmology, Inst of<br />
Ophthalmology and Visual Science, Newark, NJ;<br />
2<br />
Cornea and Laser Eye Inst- Hersh Vision Group,<br />
Teaneck, NJ *CR, f<br />
5284 — C0203 Aliphatic β-nitroalcohols for<br />
therapeutic corneoscleral tissue cross-linking:<br />
catalytic studies. David C. Paik, Q. Wen, M.<br />
Kim, Q. V. Hoang, S. L. Trokel. Ophthalmology,<br />
Columbia University, New York, NY *CR<br />
5285 — C0204 Analysis of Thickness of<br />
Corneas from Eye Banks After Application<br />
Of Isosmolar Riboflavin And Hiposmolar<br />
Riboflavin. Luiz Felipe L. Moraes 2, 1 , L. Barbosa 2 ,<br />
M. Macedo 2 , T. Rayes 2 . 1 Ophthalmology, Federal<br />
University of Pernambuco, Recife, Brazil;<br />
2<br />
Ophthalmology, Sorocaba Eye Bank, Sorocaba,<br />
Brazil<br />
5286 — C0205 Crosslinking Corneal Collagen<br />
using Rose Bengal and Green Light. Irene E.<br />
Kochevar 1 , T. Gisel 1 , E. E. Verter 1 , G. Scarcelli 1 , S.<br />
H. Yun 1 , R. H. Webb 1 , R. W. Redmond 1 , S. Melki 2 .<br />
1<br />
Wellman Center for Photomedicine, Massachusetts<br />
General Hospital, Boston, MA; 2 Boston Eye Group,<br />
Boston, MA *CR<br />
5287 — C0206 Collagen Crosslinking By<br />
Infrared Femtosecond Pulses In Ex-vivo<br />
Corneas. Juan M. Bueno, H. S. Ginis, R. Palacios,<br />
A. Pennos, P. Artal. Laboratorio de Optica,<br />
Universidad de Murcia, Murcia, Spain *CR<br />
5288 — C0207 Accelerated corneal crosslinking<br />
with pulsed light. Pavel Kamaev, W. A.<br />
Eddington, S. Rood-Ojalvo, M. D. Friedman, D.<br />
Muller. Research, Avedro, Waltham, MA *CR<br />
5289 — C0208 Long term follow-up of<br />
stiffening of rabbit corneas by WST11 using near<br />
infrared light. Arie L. Marcovich 1, 2 , A. Brandis 1 , I.<br />
Feine 3 , I. Pinkas 1 , R. Goldschmidt 1 , V. Kalchenko 4 ,<br />
D. H. Wagner 5 , Y. Salomon 3 , A. Scherz 1 . 1 Plant<br />
Sciences, Weizmann Institute of Science, Rehovot,<br />
Israel; 2 Ophthalmology, Kaplan Medical Center,<br />
Rehovot, Israel; 3 Biological Regulation, Weizmann<br />
Institute of Science, Rehovot, Israel; 4 Veterinary<br />
Resources, Weizmann Institute of Science, Rehovot,<br />
Israel; 5 Materials and Interfaces, Weizmann Institue<br />
of Science, Los Angeles, CA *CR<br />
5290 — C0209 Antimicrobial efficacy of<br />
riboflavin / UV-A collagen cross-linking at<br />
different fluences in vitro. Florence Hoogewoud,<br />
O. Richoz, F. Hafezi. Ophtalmology, University<br />
Hospital of Geneva, Geneva, Switzerland *CR<br />
5291 — C0210 Combination of Intracorneal<br />
ring segments (Ferrara and Intacts) in the care<br />
of patients with Keratoconus. Roberto Albertazzi 1 ,<br />
L. Ferlini 1 , L. D. Perrone 1 , D. M. Perrone 1 , G.<br />
Rao 1 , J. F. Alfonso 2, 3 , J. Merayo-Lloves 2, 3 . 1 Centro<br />
de Ojos Quilmes, Quilmes, Argentina; 2 Fundación<br />
de Investigacion Oftalmologica - Instituto<br />
Oftalmológico Fernández-Vega, oviedo, Spain;<br />
3<br />
University of Oviedo, oviedo, Spain *CR<br />
5292 — C0211 Hydrogen-Loaded Eye Drops<br />
Suppress Progression of Keratoconus-Like<br />
Corneal Lesion of SKC Mouse. Naoko Kato 1, 2 ,<br />
Y. Uchino 2 , E. Inagaki 2 , S. Ohta 3 , K. Tsubota 2 .<br />
1<br />
Ophthalmology, National Defense Medical<br />
College, Saitama, Japan; 2 Ophthalmology, Keio<br />
University School of Medicine, Tokyo, Japan;<br />
3<br />
Biochemistry and Cell Biology, Institute of<br />
Development and Aging Sciences, Graduate School<br />
of Medicine, Nippon Medical School, Kanagawa,<br />
Japan *CR<br />
5293 — C0212 Presence of lysyl oxidase-like<br />
enzymes in human control and keratoconic<br />
corneas. Lubica Dudakova, S. Kalasova, K.<br />
Jirsova. Laboratory of the Biology and Pathology<br />
of the Eye, Charles University, Prague, Czech<br />
Republic<br />
5294 — C0213 Anterior-segment OCT<br />
epithelial mapping in early and advanced<br />
keratoconic eyes. Feilin Zhu 1 , A. Kanellopoulos 1, 2 ,<br />
G. Asimellis 2 . 1 Ophthalmology, NYU Medical<br />
Center, New York, NY; 2 Laservision Eye Institute,<br />
Athens, Greece *CR<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
335<br />
5295 — C0214 Low-frequency dielectric<br />
spectroscopy of normal and keratoconus human<br />
cornea. Dorota Tarnawska 1, 3 , A. Kocot 1 , M.<br />
Jastrzebska 2 , E. Wylegala 3 , A. Ratuszna 2 . 1 Dept.<br />
of Biophysics and Molecular Physics, Institute of<br />
Physics, University of Silesia, Katowice, Poland;<br />
2<br />
Department of Solid State Physics, Institute of<br />
Physics, University of Silesia, Katowice, Poland;<br />
3<br />
Department of Ophthalmology, Railway Hospital,<br />
Katowice, Poland<br />
5296 — C0215 Correlation between<br />
keratoconus progression and two cornea<br />
topometric parameters: the regularity of the<br />
pachymetric map (RPM) and the Index of height<br />
decentration (IHD). George Asimellis, I. Kontari,<br />
A. Kanellopoulos. Research, LaserVision.gr Eye<br />
Institute, Athens, Greece *CR<br />
5297 — C0216 Comparison of threedimensional<br />
optical coherence tomography<br />
parameters for early keratoconus diagnosis.<br />
Shinichi Fukuda 1 , S. Hoshi 1 , M. Yamanari 2, 3 , S.<br />
Beheregaray 1 , T. Hiraoka 1 , Y. Yasuno 2 , T. Oshika 1 .<br />
1<br />
Ophthalmology, Tsukuba University, Tsukuba,<br />
Japan; 2 Computational Optics Group, Tsukuba<br />
University, Tsukuba, Japan; 3 Tomey Corporation,<br />
Nagoya, Japan *CR<br />
5298 — C0217 Decreased corneal sensitivity<br />
to chemical and thermal stimuli in keratoconus<br />
patients. Lorant Dienes 1 , K. Kranitz 1 , Z. Z. Nagy 1 ,<br />
J. Nemeth 1 , M. Acosta 2 , J. Gallar 2 , C. Belmonte 2 , I.<br />
Kovacs 1 . 1 Ophthalmology, Semmelweis University,<br />
Budapest, Hungary; 2 Instituto de Neurociencias,<br />
Univ Miguel Hernandez-CSIC, Alicante, Spain *CR<br />
5299 — C0218 Remodeling Processes in<br />
Keratoconic Epithelium. Jesus Merayo-Lloves 1 ,<br />
A. Íñigo-Portugués 1 , E. Artime 1 , F. J. Colina 1 , F.<br />
Bech 1 , J. F. Alfonso 2, 1 , L. M. Quirós 3 , A. Astudillo 4 ,<br />
M. Fernández 2, 1 , I. Alcalde 1 . 1 Ocular Surface,<br />
Fundación de Investigación Oftalmológica, Oviedo,<br />
Spain; 2 Ocular Surface, Instituto Oftalmológico<br />
Fernández-Vega, Oviedo, Spain; 3 Functional<br />
Biology, Universidad de Oviedo, Oviedo, Spain;<br />
4<br />
Pathology, Hospital Central de Asturias, Oviedo,<br />
Spain *CR<br />
5300 — C0219 Phenotype of Keratoconus<br />
Patients at King Khaled Eye Specialist Hospital.<br />
Samar A. Al-Swailem, S. C. Yiu, A. Al-Assiri, N.<br />
Asghar, A. Al-Qassimi. Anterior Segment, King<br />
Khaled Eye Specialist Hosp, Riyadh, Saudi Arabia<br />
5301 — C0220 Increased expression of<br />
secreted frizzled-related protein-1 (SFRP-1) and<br />
microtubule-associated protein light chain 3<br />
(LC3) in keratoconus. Omer Iqbal, G. Fisher, S.<br />
Vira, D. Kahn, D. Syed, J. Fareed, C. S. Bouchard.<br />
Ophthalmology, Loyola, Maywood, IL<br />
5302 — C0221 IL1B promoter polymorphisms<br />
are associated with keratoconus in a Japanese<br />
population. Takenori Mikami 1, 2 , A. Meguro 1 , T.<br />
Teshigawara 2 , M. Takeuchi 1 , M. Ishioka 1, 3 , M.<br />
Iwasaki 3 , K. Fukagawa 3 , K. Konomi 4 , J. Shimazaki 4 ,<br />
N. Mizuki 1 . 1 Ophthalmology and Visual Science,<br />
Yokohama City University Graduate School of<br />
Medicine, Yokohama, Japan; 2 Yokosuka Chuoh<br />
Eye Clinic, Yokosuka, Japan; 3 Ryogoku Eye Clinic,<br />
Tokyo, Japan; 4 Department of Ophthalmology,<br />
Ichikawa General Hospital, Tokyo Dental College,<br />
Ichikawa, Japan *CR<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm
5303 – 5324 – <strong>Wednesday</strong> – Posters<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
5303 — C0222 Keratoconus Gene Mapping:<br />
Candidate Genes in the 14q11.2 homozygous<br />
region. Govindasamy Kumaramanickavel 1 , V.<br />
Anandula 1 , V. Ramprasad 3 , N. Jeyabalan 1 , A.<br />
Ghosh 1 , R. Shetty 2 . 1 Basic Science Research,<br />
Narayana Nethralaya, Bangalore, India; 2 Cornea,<br />
Narayana Nethralaya, Bangalore, India; 3 Spinco-<br />
Biotech, Chennai, India<br />
5304 — C0223 Homozygosity Mapping of<br />
Keratoconus to 12p13.1 region: The Ideal<br />
Candidate Genes. Venkata Ramana Anandula 1 ,<br />
V. Anandula 1 , V. Ramprasad 2 , N. Jeyabalan 1 , R.<br />
Shetty 1 , A. Ghosh 1 , G. Kumaramanickavel 1 . 1 Basic<br />
Science Research, Narayana Nethralaya, Bangalore,<br />
India; 2 Advanced Genomics, Spinco Biotech,<br />
Chennai, India<br />
5305 — C0224 Use of the polygenic model to<br />
predict risk of keratoconus using GWAS data.<br />
Xiaohui Li 1, 2 , Y. Bykhovskaya 2, 3 , T. Haritunians 1 ,<br />
D. Siscovick 4 , A. J. Aldave 5 , L. B. Szczotka-<br />
Flynn 6 , S. K. Iyengar 7 , J. I. Rotter 1 , K. Taylor 1 , Y.<br />
S. Rabinowitz 3 . 1 Medical Genetics, Cedars-Sinai<br />
Medical Center, Los Angeles, CA; 2 Cornea Genetic<br />
Eye Institute, Cedars-Sinai Medical Center, Los<br />
Angeles, CA; 3 Regenerative Medicine Institute,<br />
Cedars-Sinai Medical Center, Los Angeles, CA;<br />
4<br />
Cardiovascular Health Research Unit, University<br />
of Washington, Seattle, WA; 5 The Jules Stein Eye<br />
Institute, University of California Los Angeles, Los<br />
Angeles, CA; 6 Ophthalmology & Visual Sciences,<br />
Case Western Reserve University, Cleveland,<br />
OH; 7 Epidemiology & Biostatistics, Case Western<br />
Reserve University, Cleveland, OH *CR<br />
Exhibit Hall D0067-D0100<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Clinical/Epidemiologic Research<br />
478 Vision Function and Quality of Life<br />
Moderators: Pradeep Y. Ramulu and<br />
Beatriz E. Munoz<br />
5306 — D0067 What are people rating when<br />
they rate their vision status? Associations with<br />
Vision Tests and Self-Reported Visual Function<br />
in the Salisbury Eye Evaluation Study. Mahmood<br />
El-Gasim 1 , B. E. Munoz 2 , S. K. West 2 , A. W. Scott 3 .<br />
1<br />
School of Medicine, Johns Hopkins University,<br />
Baltimore, MD; 2 Dana Center for Preventive<br />
Ophthalmology, Johns Hopkins University,<br />
Baltimore, MD; 3 Wilmer Eye Institute, Johns<br />
Hopkins University, Baltimore, MD<br />
5307 — D0068 Controlling Photophobia and<br />
Light-Induced Headache: the Use of Artificial<br />
Pupil Contact Lenses. Mary M. Jackowski 1, 2 ,<br />
B. Motter 1, 3 . 1 VA Medical Center, Syracuse,<br />
NY; 2 Ophthalmology, SUNY Upstate Medical<br />
University, Syracuse, NY; 3 Neuroscience and<br />
Physiology, SUNY Upstate Medical University,<br />
Syracuse, NY<br />
5308 — D0069 Quantifying the Impact of<br />
Vision Training using Short Duration Transient<br />
Visual Evoked Potential (SD-tVEP). Robert<br />
Orsillo 1 , P. H. Derr 2 . 1 Orsillo Vision Care,<br />
Tallahasse, FL; 2 Diopsys Inc, Pine Brook, NJ *CR<br />
5309 — D0070 Quality of life of Keratoconus<br />
Patients in an Asian Population. Hon Kiat<br />
Wong, J. Lim, W. Heng. Ophthalmology, National<br />
Healthcare Group Eye Institute, Tan Tock Seng<br />
Hospital, Singapore, Singapore<br />
5310 — D0071 Dry eye and Changes in Driving<br />
Habits: The Salisbury Eye Evaluation. Jamie<br />
Brown 1 , E. K. Akpek 1 , S. W. van Landingham 1 , S.<br />
K. West 1, 2 , B. E. Munoz 1, 2 , P. Y. Ramulu 1, 2 . 1 Johns<br />
Hopkins Wilmer Eye Institute, Baltimore, MD;<br />
2<br />
Dana Center for Preventive Ophthalmology,<br />
Baltimore, MD *CR<br />
5311 — D0072 Comparing Better-eye and<br />
Integrated Visual Field Mean Deviation as<br />
Metrics for Capturing Visual Disability. Karun<br />
S. Arora, M. V. Boland, D. S. Friedman, J. L.<br />
Jefferys, S. K. West, P. Y. Ramulu. Ophthalmology,<br />
Johns Hopkins University School of Medicine,<br />
BALTIMORE, MD *CR<br />
5312 — D0073 Comparing the Impact of<br />
Refractive and Non-Refractive Vision Loss on<br />
Disability. Nazlee Zebardast, S. K. West, B. E.<br />
Munoz, P. Y. Ramulu. Johns Hopkins Wilmer Eye<br />
Institute, Baltimore, MD<br />
5313 — D0074 Rasch analysis of the glaucomaspecific<br />
module of the Eye-tem Bank project.<br />
Konrad Pesudovs 1 , J. Khadka 1 , E. K. Fenwick 2 ,<br />
E. L. Lamoureux 2, 3 . 1 NHMRC Ctr Clin Eye Res/<br />
Optometry, Flinders University SA, Adelaide, SA,<br />
Australia; 2 Centre for Eye Research Australia,<br />
University of Melbourne, Melbourne, VIC,<br />
Australia; 3 Singapore Eye Research Institute,<br />
Singapore National Eye Centre, Singapore,<br />
Singapore<br />
5314 — D0075 Cognitive dysfunction reduces<br />
vision-specific quality of life in older Asian<br />
adults. Peggy P. Chiang 1, 3 , C. Sabanayagam 1,<br />
3<br />
, Y. Zheng 5 , T. Y. Wong 1, 4 , E. L. Lamoureux 2,<br />
1<br />
. 1 Epidemiol, Hlth Services Rsrch, Singapore<br />
Eye Research Inst, Singapore, Singapore;<br />
2<br />
Ophthalmology, Centre for Eye Research Australia,<br />
University of Melbourne, Melbourne, VIC,<br />
Australia; 3 Duke-NUS Graduate Medical School,<br />
Singapore, Singapore; 4 Ophthalmology, Department<br />
of Ophthalmology, National University of<br />
Singapore, Singapore, Singapore; 5 Ophthalmology,<br />
Zhongshan Ophthalmic Center, Sun Yat-Sen<br />
University, Guangzhou, China *CR<br />
5315 — D0076 Assessment of Disability<br />
Weights Associated with Visual Acuity<br />
Impairment in Patients from a University<br />
Hospital in Brazil. Solange R. Salomao 1 , N. N.<br />
Cavascan 1 , A. Berezovsky 1 , M. R. Mitsuhiro 1 ,<br />
P. Y. Sacai 1 , A. Araujo-Filho 1 , P. A. Morales 1 ,<br />
S. E. Watanabe 1 , R. Belfort 1 , L. B. Ellwein 2 .<br />
1<br />
Departamento de Oftalmologia, Universidade<br />
Federal de Sao Paulo, Sao Paulo, Brazil; 2 NEI,<br />
Bethesda, MD *CR<br />
5316 — D0077 New Method for the<br />
Classification of Vitreous Floaters and Study<br />
of their Correlations with Ocular Biometry.<br />
Irene Ruiz 1, 2 , J. J. Rozema 1, 2 , M. B. Tassignon 1, 2 .<br />
1<br />
Ophthalmology, Antwerp University Hospital,<br />
Edegem, Belgium; 2 Medicine and Health Science,<br />
University of Antwerp, Wilrijk, Belgium<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
336<br />
5317 — D0078 Participants’ experiences in a<br />
clinical trial for vision restoration: Motivation<br />
to participate, visual perception and functional<br />
use, and experience of loss following termination.<br />
Frank J. Lane 1 , P. R. Troyk 2 , K. P. Nitsch 1 .<br />
1<br />
Pyschology, Illinois Insitute of Technology,<br />
Chicago, IL; 2 Biomedical Engineering, Illinois<br />
Insitute of Technology, Chicago, IL *CR<br />
5318 — D0079 Developing a questionnaire to<br />
measure the quality of life of Blepharitis patients.<br />
Linda Bourque 1, 2 , M. M. Kelley 1, 2 , K. Hosseini 2 .<br />
1<br />
Fielding School of Public Hlth, University of<br />
California, Los Angeles, Los Angeles, CA; 2 InSite<br />
Vision, Inc., Alameda, CA *CR, f<br />
5319 — D0080 Evaluation of Methods<br />
Handling Missing Diary Data for Statistical<br />
Analysis in Dry Eye Studies. Hui-Chun T. Hsu, D.<br />
W. Usner, R. Abelson. Biostatistics, Statistics and<br />
Data Corporation, Tempe, AZ *CR<br />
5320 — D0081 Visual Function Affects<br />
Reported Depressive Symptoms and Suicidal<br />
Ideation in Older Adults. Priyanka Jain 1 , M.<br />
Smith 2 , J. V. Odom 1 , G. Miller 1 , C. Moore 1 , M.<br />
J. Leys 1 . 1 WVU Eye Institute, Morgantown,<br />
WV; 2 Psychology, West Virginia University,<br />
Morgantown, WV<br />
5321 — D0082 Subjective Influences on Visual<br />
Acuity Testing Performance: A Prospective<br />
Study with Non-accommodating Intra-ocular<br />
Lenses. Arvind V. Iyer 1 , E. R. Chu 2 , B. X. Pan 2 , B.<br />
S. Tjan 3 , A. A. Sadun 2 , K. L. Lu 2 , F. E. Udwadia 4 .<br />
1<br />
Biomedical Engineering, University of Southern<br />
California, Los Angeles, CA; 2 Ophthalmology,<br />
University of Southern California, Los Angeles,<br />
CA; 3 Psychology, University of Southern California,<br />
Los Angeles, CA; 4 Aerospace and Mechanical<br />
Engineering, University of Southern California, Los<br />
Angeles, CA *CR<br />
5322 — D0083 Educational and vision-assistive<br />
smartphone Apps for patients: a quantitative<br />
evaluation. Stephanie Kletke 1 , S. Arora 2 , F. Adatia 3 .<br />
1<br />
Medicine, McMaster University, Hamilton,<br />
ON, Canada; 2 Ophthalmology, University of<br />
Alberta, Edmonton, AB, Canada; 3 Ophthalmology,<br />
University of Calgary, Calgary, AB, Canada<br />
5323 — D0084 Patient Experience During the<br />
Fitting Process for the Prosthetic Replacement of<br />
the Ocular Surface Ecosystem (PROSE) Device.<br />
Eda Dou, Y. Wang, R. M. St Clair, M. N. Lee, M.<br />
Rosenblatt, P. Sood, A. G. Alzaga Fernandez, C.<br />
E. Starr, J. Ciralsky, K. C. Sippel. Ophthalmology,<br />
Weill Cornell Medical College, New York, NY<br />
5324 — D0085 Importance of Physical Activity<br />
and Low Vision: Preliminary Findings from<br />
an Adaptive Sport and Recreation Program<br />
for Military Service Members with Low<br />
Vision. Laura E. Dreer 1, 2 , C. Block 1 , A. Wood 1 , S.<br />
Robinson 2 , M. Goff 2 , L. Malone 2 . 1 Ophthalmology/<br />
Callahan Eye Fndtn Hosp, Univ of Alabama<br />
at Birmingham, Birmingham, AL; 2 Lakeshore<br />
Foundation, Birmingham, AL *CR
<strong>Wednesday</strong> – Posters – 5325 – 5347<br />
5325 — D0086 Fear of falling, activity<br />
restriction and self-reported physical function<br />
among older adults with glaucoma. Alex A.<br />
Black, J. M. Wood. School of Optometry and Vision<br />
Science, Queensland University of Technology,<br />
Brisbane, QLD, Australia<br />
5326 — D0087 Can chronic visual symptoms<br />
measures accurately predict acute visual<br />
discomfort symptoms? Stefanie A. Drew 1 , A.<br />
Escobar 2 , C. Liu 3 , E. Castellanos 3 , L. R. Stark 4 ,<br />
E. Borsting 4 , C. Chase 3 . 1 Psychology, California<br />
State University, Northridge, Northridge, CA;<br />
2<br />
2U, Inc., Landover, MD; 3 College of Optometry,<br />
Western University of Health Sciences, Pomona,<br />
CA; 4 Southern California College of Optometry,<br />
Fullerton, CA f<br />
5327 — D0088 Contrast Sensitivity,<br />
Electroretinography and Optical Coherence<br />
Tomography Changes in Young Subjects After<br />
an Acute Unacclimatized Short Exposure to<br />
High Altitude. Mehmet S. Karakucuk, B. Polat,<br />
E. Mirza, H. Arda, K. Gumus, A. Oner. Dept. of<br />
Ophthalmology, Erciyes University Faculty of<br />
Medicine, Kayseri, Turkey<br />
5328 — D0089 Age-related eye disease and<br />
cognitive status. Solmaz Moghadaszadeh 1 , H.<br />
Boisjoly 1, 2 , M. Kergoat 3 , J. Rousseau 3 , F. Djafari 1, 2 ,<br />
E. E. Freeman 1, 2 . 1 Ophtalmology, Maisonneuve-<br />
Rosemont’s Hospital, Montreal, QC, Canada;<br />
2<br />
Ophthalmology, Université de Montréal, Montreal,<br />
QC, Canada; 3 Centre de Recherche, Institut<br />
universitaire de gériatrie de Montréal, Montreal,<br />
QC, Canada<br />
5329 — D0090 DIGS and ADAGES:<br />
Relationship Between Rates of Binocular<br />
Visual Field Loss and Vision-Related Quality of<br />
Life in Glaucoma. Renato Lisboa 1, 2 , Y. Chun 1, 3 ,<br />
L. M. Zangwill 1 , R. N. Weinreb 1 , P. Rosen 1 , J.<br />
M. Liebmann 4 , C. A. Girkin 5 , F. A. Medeiros 1 .<br />
1<br />
Ophthalmology, Hamilton Glaucoma Center, La<br />
Jolla, CA; 2 Ophthalmology, Federal University of<br />
São Paulo, São Paulo, Brazil; 3 Ophthalmology,<br />
Chung-Ang University, Seoul, Republic of Korea;<br />
4<br />
Opthtalmology, New York Eye and Ear Infirmary,<br />
Ney York, NY; 5 Ophthalmology, University of<br />
Alabama, Birmingham, AL *CR, f<br />
5330 — D0091 Utility and Uncorrected<br />
Refractive Error. Nina Tahhan 1, 2 , E. B. Papas 1, 3 ,<br />
T. R. Fricke 1 , K. D. Frick 4 , B. A. Holden 1, 3 . 1 Brien<br />
Holden Vision Institute, Sydney, NSW, Australia;<br />
2<br />
School of Optometry & Vision Science, UNSW,<br />
Sydney, NSW, Australia; 3 Vision Cooperative<br />
Research Centre, Sydney, NSW, Australia; 4 Johns<br />
Hopkins Bloomberg School of Public Health,<br />
Baltimore, MD *CR<br />
5331 — D0092 An iPad Test of Letter Contrast<br />
Sensitivity. Mark A. Bullimore 1 , M. E. Jansen 2 , E. J.<br />
Kollbaum 2 , P. S. Kollbaum 2 . 1 College of Optometry,<br />
University of Houston, Boulder, CO; 2 School of<br />
Optometry, Indiana University, Bloomington, IN<br />
*CR<br />
5332 — D0093 Fear of falling in age-related<br />
macular degeneration. Sabyasachi Sengupta, S.<br />
W. van Landingham, R. W. Massof, E. Chan, D.<br />
S. Friedman, P. Y. Ramulu. Wilmer Eye Institute,<br />
Baltimore, MD *CR<br />
5333 — D0094 Photophobia and Light-<br />
Induced Headache: Novel Long-Term<br />
Effects of Pilocarpine. Brad Motter 1, 3 , M. M.<br />
Jackowski 1, 2 . 1 VA Medical Center, Syracuse,<br />
NY; 2 Ophthalmology, SUNY Upstate Medical<br />
University, Syracuse, NY; 3 Neuroscience and<br />
Physiology, SUNY Upstate Medical University,<br />
Syracuse, NY<br />
5334 — D0095 Is visual impairment just<br />
another comorbid condition? Bonnielin K.<br />
Swenor, B. E. Munoz, S. K. West. Ophthalmology,<br />
Johns Hopkins Wilmer Eye Institute, Baltimore,<br />
MD<br />
5335 — D0096 Development of an Arabic<br />
version of the National Eye Institute Visual<br />
Function Questionnaire as a tool to study eye<br />
diseases patients in Egypt. Nizar F. Saleh 1, 2 , A. A.<br />
Salama 3 , M. A. Abdel-Baqy 4 , M. E. Israel 5 , G. A.<br />
Elhawary 5 , A. E. Radwan 3 , T. M. EL Nakhal 2 , I. T.<br />
Elkhateb 6 , A. M. Kassem 2 , M. Amgad 6 . 1 Cortoba Eye<br />
Femtolaser Centers, Cairo, Egypt; 2 Ophthalmology,<br />
Faculty of Medicine University of Alexandria,<br />
Alexandria, Egypt; 3 Ophthalmology, Faculty of<br />
Medicine - Menofeyya University, Shebin El-Kom,<br />
Egypt; 4 Alexandria Regional Center for Women’s<br />
Health & Development, Alexandria, Egypt; 5 Faculty<br />
of Medicine - Ain Shams University, Cairo, Egypt;<br />
6<br />
Faculty of Medicine - Cairo University, Cairo,<br />
Egypt<br />
5336 — D0097 The Impact of Visual Field Loss<br />
and Hearing Loss on Social Function. Bei Bei<br />
Chen, N. Zebardast, F. R. Lin, P. Y. Ramulu, D. S.<br />
Friedman. Johns Hopkins, Baltimore, MD *CR<br />
5337 — D0098 The Effect of Comprehensive<br />
Vision Rehabilitation on Self-Administration<br />
of Medication in Patients with Central Vision<br />
Loss. Catherine J. Choi, J. Wallis, M. Jackson.<br />
Ophthalmology, Massachusetts Eye and Ear<br />
Infirmary, Boston, MA f<br />
5338 — D0099 Blue streetlights effect on visual<br />
acuity in glaucoma. Kozo Masuda 1 , H. Uozato 2 .<br />
1<br />
Health and Social Services, Osaka University of<br />
Human Sciences, Settsu, Japan; 2 Ophthalmology<br />
and Visual Science, Kitasato University,<br />
Sagamihara, Japan<br />
5339 — D0100 How Maryland Eye Care<br />
Practitioners Complete the Motor Vehicle<br />
Administration (MVA)Vision Screening<br />
Form. Ruidi Wang, R. Miller, H. D. Jampel.<br />
Ophthalmology, Johns Hopkins Wilmer Eye<br />
Institute, Baltimore, MD *CR<br />
Exhibit Hall D0101-D0113<br />
<strong>Wednesday</strong>, May 08, 2013 2:45 PM-4:30 PM<br />
Eye Movements / Strabismus / Amblyopia /<br />
Neuro-Ophthalmology<br />
479 Oculoplastics and Orbital Disease:<br />
Prognosis, Diagnosis and Outcomes<br />
Moderator: Timothy J. McCulley<br />
5340 — D0101 Periorbital and Ocular Injury<br />
from Industrial Hooks. Daniel G. Straka, S.<br />
Thinda, M. R. Melson, L. A. Mawn. Ophthalmology,<br />
Vanderbilt Eye Institute, Nashville, TN *CR<br />
5341 — D0102 Predictors and Outcomes of<br />
Orbital Floor Fractures requiring Surgical<br />
repair. Clarissa Cheng, L. Lee. Ophthalmology,<br />
National Healthcare Group Eye Institute, Tan Tock<br />
Seng Hospital, Singapore, Singapore<br />
5342 — D0103 Observation of the orbital floor<br />
with magnetic resonance imaging after surgery<br />
for orbital floor fractures. Hidetoshi Onda, T.<br />
Ueda, Y. Kamijo, M. Yoshida. Ophthalmology,<br />
Showa Univ Sch of Medicine, Tokyo, Japan<br />
5343 — D0104 Orbital and Preseptal Cellulitis:<br />
Our Experience at a Referral Center in<br />
Southeast Louisiana. Namita Bhardwaj 1, 2 , A. B.<br />
al-Hariri 1 . 1 Department of Ophthalmology, Ochsner<br />
Clinic Foundation, New Orleans, LA; 2 Department<br />
of Ophthalmology, Louisiana State University, New<br />
Orleans, LA<br />
5344 — D0105 Orbital Cerebrospinal Fluid<br />
Leak Following Pterional Orbitozygomatic<br />
Craniotomy. Zakeya M. Alsadah 1 , M. K. Yoon 3 , T.<br />
J. McCulley 2, 1 . 1 oculoplastics, kkesh, riyadh, Saudi<br />
Arabia; 2 oculoplastics, Wilmer Eye Institute, Johns<br />
Hopkins, baltimore, MD; 3 Massachusetts Eye and<br />
Ear Infirmary, boston, MA<br />
5345 — D0106 Cosmetic and quality of life<br />
outcomes of the direct brow lift. Srinivas Sai A.<br />
Kondapalli 1 , C. N. Czyz 2 , J. A. Foster 3 , K. V. Cahill 3 .<br />
1<br />
Ophthalmology, Loyola University Medical Center,<br />
Westchester, IL; 2 Ophthalmology, Ohio University,<br />
Doctor’s Hospital, Columbus, OH; 3 Ophthalmology,<br />
The Ohio State University, Columbus, OH<br />
5346 — D0107 The effect of eyelid<br />
manipulation on exophthalmometry values.<br />
Aubrey Gilbert, M. K. Yoon. Ophthalmology,<br />
Massachusetts Eye and Ear Infirmary, Boston, MA<br />
5347 — D0108 Age Related Gender Differences<br />
in the Occurrence of Acquired Nasolacrimal<br />
Duct Obstruction in Saudi Arabia. Laura Phan 1 ,<br />
T. J. McCulley 1, 2 . 1 Ophthalmology, Wilmer Eye<br />
Institute, Baltimore, MD; 2 Ophthalmology, King<br />
Khaled Eye Specialist Hospital, Riyadh, Saudi<br />
Arabia<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
337
5348 – 5352 – <strong>Wednesday</strong> – Posters<br />
5348 — D0109 Giant fornix syndrome with<br />
chronic methicillin resistant staphylococcus<br />
aureus conjunctivitis causing nasal lacrimal<br />
duct obstruction. Jackson F. Lever 1 , E. Eubanks 2 ,<br />
C. K. Gupta 1 , A. Barmettler 1 , J. Servat 3 , F.<br />
Nesi-Eloff 1 . 1 Beaumont Eye Institute, William<br />
Beaumont Hospital, Royal Oak, MI; 2 School of<br />
Medicine, Wayne State University, Detroit, MI;<br />
3<br />
Ophthalmology, Yale School of Medicine, New<br />
Haven, CT<br />
5349 — D0110 Pott’s Puffy Tumor Arising<br />
From Pansinusitis - A Mimicker of Preseptal<br />
Cellulitis. Li Wei Heng, E. Poh. Ophthalmology,<br />
Tan Tock Seng Hospital, Singapore, Singapore<br />
5350 — D0111 Ki67 Proliferation Index<br />
as a Prognostic Factor in Ocular Adnexal<br />
Lymphoma. Matthew C. Sniegowski, B. Esmaeli.<br />
University of Texas MD Anderson Cancer Cencer,<br />
Houston, TX<br />
5351 — D0112 Histopathology after temporary<br />
tarsorrhaphy. Larissa K. Ghadiali 1 , K. C. Piotti 2 ,<br />
G. J. Lelli 3 . 1 Ophthalmology, New York Medical<br />
College, Valhalla, NY; 2 Department of Pathology<br />
and Laboratory Medicine, New York Presbyterian<br />
Hospital-Weill Cornell Medical Center, New York,<br />
NY; 3 Ophthalmology, New York Presbyterian<br />
Hospital-Weill Cornell Medical Center, New York,<br />
NY<br />
5352 — D0113 Recognition of External Eye<br />
Photos: HIPAA Implications. Maya H. Maloney,<br />
E. Bradley. Ophthalmology, Mayo Clinic,<br />
Rochester, MN<br />
<strong>Wednesday</strong> Posters<br />
2:45 pm – 4:30 pm<br />
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.<br />
338
<strong>Wednesday</strong> – Lectures – 5353 – 5354<br />
6E<br />
<strong>Wednesday</strong>, May 08, 2013 6:30 PM-7:15 PM<br />
481A Cogan Award and Lecture<br />
The Cogan Award recognizes a young researcher<br />
who is 40 years of age or less at the time of<br />
nomination. This person will have made important<br />
and worthwhile contributions to research in<br />
ophthalmology or visual science which directly<br />
relates to disorders of the human eye or visual<br />
system, and will have shown substantial promise for<br />
the future.<br />
— 5:30 Introduction. Peter Sterling. Library,<br />
University of Pennsylvania, Philadelphia, PA<br />
5353 — 5:35 Neural Circuits and Synapses<br />
for Early Visual Processing. Jonathan B. Demb.<br />
Ophthalmology & Visual Science, Yale University,<br />
New Haven, CT<br />
6E<br />
<strong>Wednesday</strong>, May 08, 2013 6:30 PM-7:15 PM<br />
481B Friedenwald Award and Lecture<br />
The Friedenwald Award is presented annually<br />
to recognize outstanding research in the basic or<br />
clinical sciences as applied to ophthalmology.<br />
— 6:30 Introduction. Joseph A. Izatt. Biomed<br />
Engineering/Ophthal, Duke University, Durham,<br />
NC *CR<br />
5354 — 6:35 Functional & Structural Optical<br />
Coherence Tomography. David Huang. Casey Eye<br />
Institute, Oregon Health & Science Univ, Portland,<br />
OR *CR<br />
<strong>Wednesday</strong> Lectures<br />
6:30 pm – 7:15 pm<br />
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.<br />
339
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