Wednesday - ARVO

Wednesday 

May 8, 2013 

LIFE-CHANGING RESEARCH 

MAY 5 – 9 | SEATTLE

Wednesday, May 8 

1–2:30pm 

Room 8:30–10:15am 11am–12:45pm Workshop/SIG 2:45–4:30pm 5:30–6:15pm 6:30–7:15pm 

6A 

401 Biochemistry of Glaucoma [BI] 

#4002-4008 

454 What Role Do Mueller Glial Cells 

Play in Retinal Pathology? — SIG 

[RC, RE] 

6B 

402 New Ideas [GL] #4009-4015 

424 Genetics I [GL] #4497-4503 

455 Diabetic Retinopathy: Where We Are 

and a Path to Progress — SIG [RE] 

459 Neuroprotection [GL] #4938-4944 

6C 

403 Retinitis Pigmentosa II [RE] 

#4016-4022 

425 AMD: Novel and Combination 

Therapies [RE] #4504-4509 

456 Epigenetic Mechanism and Ocular 

Diseases —SIG [RC] 

460 ROP: Management [RE] #4945- 

4951 

6E 

404 DR: Therapeutic Effects [RE] 

#4023-4029 

426 Macular Disease other than AMD II 

[RE] #4510-4516 

461 Retinal Detachment II [RE] 

#4952-4958 

481A Cogan Award and 

Lecture 

481B Friedenwald Award and 

Lecture 

606-607 

405 Host Responses to Ocular 

Herpesvirus Infection — What Have 

We Learned and What Is the Future 

Direction? — Minisymposium [IM, CO] 

#4030-4034 

427 Ocular Immune Responses [IM] 

#4517-4523 

449 Managing Your Research, Teaching 

and Service: “Dollarly/Scholarly” 

608 

406 Myopia and Emmetropization [AP] 

#4035-4041 

428 Uveal Melanoma: Experimental 

Therapeutics [AP] #4524-4530 

609 

407 Cell Biology Impacts Lens Function 

[LE] #4042-4048 

429 A Global View of Posterior 

Capsule Opacification — 

Minisymposium [LE] #4531-4534 

462 Lens Proteins/Physical Chemistry 

[LE] #4959-4965 

611-614 

615-617 

618-620 

TCC 301/302 

TCC 303 

TCC 304 

408 Differentiation of Stem and iPS 

Cells [RC] #4049-4055 

409 Purine Signaling in the Eye: 

Role in Health and Disease — 

Minisymposium [PH, CO, RC] 

#4056-4062 

411 Keratoconus and Biomechanics 

[CO] #4069-4075 

412 Photoreceptors: Structure, 

Transduction, Signaling [VN] #4076- 

4082 

430 Physiologic Vascularization in 

Retinopathies [RC] #4535-4541 

431 Eye Care: Who’s Not Getting It and 

Why It Matters [CL] #4542-4548 

433 Stroma Keratocytes, Development 

and Dystrophies [CO] #4555-4561 

434 Genetics, Development and Aging 

[VN] #4562-4568 

450 Getting Published: The Good, the 

Bad, and the Ugly 

451 Indo-US Collaborative Vision 

Research Program 

457 Dietary Factors and Eye 

Health — SIG [CO, BI, RE, GL] 

452 Pizza with the Experts #2 

453 NIH-CSR Peer Review Workshop 

448 Multidisciplinary Ophthalmic 

Imaging Group: Functional Optical 

Imaging [MOI] 

463 Transplanted and Endogenous 

Cells as Effectors of Outer Retinal 

Repair — Minisymposium [RC] 

#4966-4970 

Exhibit Halls, 11am–6pm 

NAEVR Central, 

Skybridge, 9am–5pm 

Networking Happy Hour, 

Exhibit Halls, 4:30–6pm 

ARVO Classical Concert 

Nordstrom Recital Hall, 

Benaroya Hall 

8–10pm 

ARVO Karaoke! 

Club Noc Noc 

9pm–12Midnight 

TCC 305 

435 Neuro-Ophthalmology: Novel 

Treatments and Mechanisms of 

Disease [EY] #4569-4575 

465 Amblyopia: Neural Mechanisms 

and Treatment [EY, VI] #4978-4984 

TCC LL 4/5 

410 Spatial Vision, Visual 

Psychophysics and Aging II [VI] 

#4063-4068 

432 Refractive Errors, Myopia II [VI] 

#4549-4554 

458 New Paradigms and Emerging 

Techniques for Minimalist Macular 

Photocoagulation — SIG [RE] 

464 Advances in Ocular Genetics 

[GEN] #4971-4977 

266

Wednesday, May 8 n Posters 

8:30–10:15am 

Session Session Program Board 

Number Title Number Number 

413 AMD II, RE [RE] #4083-4129 (A0001-A0047) 

414 AMD III, RE [RE] #4130-4176 (A0048-A0094) 

415 Retinal and Photoreceptor Degeneration II: Cell Biology [RC] #4177-4202 (B0170-B0195) 

416 Uveal Melanoma [AP, PH] #4203-4249 (B0196-B0242) 

417 Accommodation and Presbyopia Correction [VI] #4250-4283 (B0287-B0320) 

418 Antibiotics and Corneal Disease [PH, CO] #4284-4307 (C0022-C0045) 

419 Dry Eye and Lacrimal Gland IV [CO] #4308-4362 (C0046-C0100) 

420 Neuro-Ophthalmology: Papilledema, Characterization 

of Rare Diseases, and Methods of Evaluation [EY] #4363-4382 (D0001-D0020) 

421 Eye Care [CL] #4383-4428 (D0021-D0066) 

422 Ocular Trauma [CL] #4429-4441 (D0114-D0126) 

423 Ocular Blood Flow; Surgery and Wound Healing [GL] #4442-4496 (D0182-D0236) 

11am–12:45pm 



436 AMD I, BI [BI] #4576-4594 (A0095-A0113) 

437 Translational Approaches in AMD and DR [RC] #4595-4627 (A0146-A0178) 

438 Retinal Flow and VEGF [PH, RC] #4628-4673 (B0092-B0137) 

439 Ocular Nanoimaging, Nanobiosensors and 

Nanodiagnostics [NT] #4674-4704 (B0243-B0273) 

440 Strabismus: Treatment Methods [EY] #4705-4717 (B0274-B0286) 

441 Corneal Development, Differentiation, Dystrophies, 

Genetics [CO] #4718-4742 (C0101-C0125) 

442 Surgery and Wound Healing [GL] #4743-4797 (D0127-D0181) 

443 Imaging III [GL] #4798-4852 (D0237-D0291) 

444 Choroid and Sclera Imaging [MOI] #4853-4870 (D0292-D0309) 

445 Imaging of Animal Models [MOI] #4871-4897 (D0310-D0336) 

446 Imaging I [RE] #4898-4916 (D0337-D0355) 

447 DME: OCT and Function [RE] #4917-4937 (D0356-D0376) 

2:45–4:30pm 



466 AMD II, BI [BI] #4985-5016 (A0114-A0145) 

467 Visual Functions in AMD [VI] #5017-5042 (A0179-A0204) 

468 Drug Delivery III [PH] #5043-5075 (B0001-B0033) 

469 Dysfunction in Disease: Translational Studies [VN] #5076-5100 (B0034-B0058) 

470 Dysfunction in Disease: Clinical Studies [VN] #5101-5133 (B0059-B0091) 

471 Retinal Development II: Retina and Vasculature [RC] #5134-5165 (B0138-B0169) 

472 Myopia II [AP] #5166-5185 (B0321-B0340) 

473 Non-infectious Inflammation [IM] #5186-5206 (C0001-C0021) 

474 Corneal Infection/Inflammation I [IM] #5207-5222 (C0126-C0141) 

475 Corneal Wound Repair, Transparency II [CO, BI] #5223-5237 (C0142-C0156) 

476 Corneal Stroma and Keratocytes [CO] #5238-5258 (C0157-C0177) 

477 Corneal Cross-linking and Keratoconus [CO] #5259-5305 (C0178-C0224) 

478 Vision Function and Quality of Life [CL] #5306-5339 (D0067-D0100) 

479 Oculoplastics and Orbital Disease: Prognosis, 

Diagnosis and Outcomes [EY] #5340-5352 (D0101-D0113) 

Poster board numbers indicate location: 

Poster Area A and B = South Exhibit Hall; Poster Area C and D = North Exhibit Hall 

4:30–5:30pm: All Posters — authors will be present at poster boards 

4:30–6pm: Networking Happy Hour in Exhibit/Poster Halls 

267

NOTES 

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268 266

Wednesday – Papers/Minisymposium – 4002 – 4021 

6A 

Wednesday, May 08, 2013 8:30 AM-10:15 AM 

Biochemistry/Molecular Biology / Biochemistry/ 

Molecular Biology 

401 Biochemistry of Glaucoma 

Moderators: Stanislav I. Tomarev and 

Ernst R. Tamm 

4002 — 8:30 Myocilin affects differentiation 

of oligodendrocytes and regulates myelination 

of the optic nerve via Lingo-1/RhoA signaling. 

Stanislav I. Tomarev 1 , H. Kwon 1 , N. Nakaya 1 , M. 

S. Abu-Asab 2 . 1 SRGCB, LRCMB, National Eye 

Institute, Bethesda, MD; 2 Histopathology Core 

Facility, National Eye Institute, Bethesda, MD 

4003 — 8:45 Genomewide DNA methylation 

analysis of human trabecular meshwork 

cells with dexamethasone stimulation. Akira 

Matsuda, N. Ebihara, A. Murakami. Department 

of Ophthalmology, Juntendo Univ School of Med, 

Tokyo, Japan *CR 

4004 — 9:00 Stabilization of Myocilin with 

Small Molecules Prevents Its Aggregation. 

Raquel L. Lieberman, S. E. Hill, R. K. Donegan, K. 

C. Turnage. School of Chemistry & Biochemistry, 

Georgia Institute of Technology, Atlanta, GA 

4005 — 9:15 PGC-1alpha Signaling Regulates 

Retinal Ganglion Cell Injury Responses And 

Atrocyte Reactivity. Jeremy M. Sivak 1, 2 , X. Guo 1 , 

S. Dason 2 , A. Nahirny 1 . 1 Vision Sciences, Toronto 

Western Hospital, University Health Network, 

Toronto, ON, Canada; 2 Ophthalmology and Vision 

Sciences, University of Toronto, Toronto, ON, 

Canada 

4006 — 9:30 Subcellular mislocalization and 

loss of function of mutant Gpnmb proteins. 

Alexander C. Theos. Human Science, Georgetown 

University, Washington, DC 

4007 — 9:45 Cochlin and phosphatidylcholines 

interact with SLC44A2 channel on the 

trabecular meshwork cells. Sanjoy K. 

Bhattacharya, M. Martinez, A. Aljohani, R. K. Lee. 

Bascom Palmer Eye Institute, Univ of Miami Miller 

Sch of Med, Miami, FL *CR 

4008 — 10:00 Disruption of the homeostatic 

balance between TGF-β and BMPs in the 

outflow tissues of the CTGF-based Glaucoma 

mouse model. Sabrina Kuespert, E. R. Tamm, R. 

Fuchshofer. University Regensburg, Institut of 

Human Anatomy and Embryology, Regensburg, 

Germany 

6B 


Glaucoma 

402 New Ideas 

Moderators: Jonathan G. Crowston, Peng T. Khaw 

and George A. Cioffi 

4009 — 8:30 Glucose-induced Temporary 

Visual Recovery in Human Glaucoma: A 

Prospective, Double-blind, Randomised Study. 

Robert J. Casson, G. Chidlow, A. Ebneter, G. 

Han, J. Gilhotra, J. P. Wood. SA Institute of 

Ophthalmology, SA Inst of Ophthalmol, Adelaide 

Univ, Adelaide, SA, Australia f 

4010 — 8:45 Radiation Treatment Does Not 

Protect the Rat Optic Nerve from Elevated 

Intraocular Pressure (IOP)-Induced Injury. 

Elaine C. Johnson, W. Cepurna, J. C. Morrison. 

Ophthalmology, Casey Eye Institute-OHSU, 

Portland, OR 

4011 — 9:00 Estrogen Pathway Polymorphisms 

in Relation to Primary Open Angle Glaucoma: 

A Gender-Specific Analysis from Patients in the 

United States. Louis R. Pasquale 1, 2 , S. Loomis 1 , 

B. Yaspan 3 , J. H. Kang 2 , R. N. Weinreb 6 , J. E. 

Richards 7 , M. A. Hauser 4 , J. L. Haines 5 , J. L. 

Wiggs 1 . 1 Ophthalmology, Mass Eye & Ear Infirmary, 

Boston, MA; 2 Medicine, Brigham and Women’s 

Hospital, Boston, MA; 3 Genentech, Inc, San 

Francisco, CA; 4 Ophthalmology, Duke University, 

Durham, NC; 5 Center for Human Genetics 

Research, Vanderbilt University, Nashville, 

TN; 6 Ophthalmology, UCSD, San Diego, CA; 

7 

Ophthalmology and Visual Sciences, University of 

Michigan, Ann Arbor, MI *CR 

4012 — 9:15 A Novel Device for Clinical 

Measurement of Corneal Elasticity. Christopher 

K. Leung 1 , C. Ye 1 , M. Ko 2 , L. Leung 2 , D. Lam 2 . 

1 

Ophthalmology and Visual Sciences, The Chinese 

University of Hong Kong, Hong Kong, Hong Kong; 

2 

Mechanical Engineering, Hong Kong University of 

Science and Technology, Hong Kong, Hong Kong 

*CR 

4013 — 9:30 A Potential Role for the 

Hypothalamic Orexin System in Mediating 

Intraocular Pressure Fluctuations. Brian 

C. Samuels 1 , N. Hammes 1 , P. L. Johnson 2 , A. 

Shekhar 3, 4 . 1 Department of Ophthalmology, Eugene 

& Marilyn Glick Eye Inst, Ind Univ, Indianapolis, 

IN; 2 Department of Anatomy, Indiana University, 

Indianapolis, IN; 3 Department of Psychiatry, 

Indiana University, Indianapolis, IN; 4 Clinical and 

Translational Sciences Institute, Indiana University, 

Indianapolis, IN *CR 

4014 — 9:45 Pulse-induced Trabecular 

Meshwork (TM) Movement in Humans: 

Characterization by Phase-sensitive OCT 

(PhS-OCT). Murray A. Johnstone 2 , P. Li 1 , T. T. 

Shen 1, 2 , R. K. Wang 1 . 1 Bioengineering, University 

of Washington, Seattle, WA; 2 Ophthalmology, 

University of Washington, Seattle, WA *CR 

4015 — 10:00 A quantitative approach to the 

analysis of visual field defect location and its 

relationship to measures of disability. Michael V. 

Boland, P. Y. Ramulu, K. S. Arora, J. L. Jefferys, D. 

S. Friedman. Wilmer Eye Institute, Johns Hopkins 

University, Baltimore, MD *CR 

6C 


Retina 

403 Retinitis Pigmentosa II 

Moderators: Yasuhiro Ikeda and David J. Wilson 

4016 — 8:30 Long-term efficacy and safety of 

treatment of retinitis pigmentosa with valproic 

acid. Christine N. Kay, S. Bhalla. Ophthalmology, 

University of Florida, Gainesville, FL 

4017 — 8:45 Visual Function Improvements 

following Electroacupuncture for Retinitis 

Pigmentosa. Ava K. Bittner 1 , J. Gould 3 , C. 

Rozanski 1 , A. Rosenfarb 2 , M. R. DeJong 3 , A. 

Benavente-Perez 4 , G. Dagnelie 1 . 1 Ophthalmology, 

Johns Hopkins University, Baltimore, MD; 

2 

Acupuncture Health Associates, Westfield, NJ; 

3 

Johns Hopkins University, Baltimore, MD; 4 SUNY 

College of Optometry, New York, NY f 

4018 — 9:00 Evaluation of peripheral retinal 

vasculitis in retinitis pigmentosa using wide-field 

fluorescein angiography. Matthew B. Kaufman 1, 2 , 

C. A. Medina-Mendez 1, 2 , T. R. Friberg 1, 2 , A. W. 

Eller 1, 2 . 1 Ophthalmology, UPMC Eye Center, 

Pittsburgh, PA; 2 Ophthalmology, University of 

Pittsburgh School of Medicine, Pittsburgh, PA *CR 

4019 — 9:15 Inheritance of Retinitis 

Pigmentosa: Update in the Era of Genetic 

Testing. Kari E. Branham, J. Huang, K. T. 

Jayasundera, J. R. Heckenlively. Ophthalmology 

and Visual Sciences, University of Michigan, Ann 

Arbor, MI *CR 

4020 — 9:30 Ultra wide-field autofluorescence 

is useful to evauluate residual retinal functions 

in patients with Retinitis Pigmentosa. Shuntaro 

Ogura, T. Yasukawa, M. Yoshida, Y. Ogura. 

Department of Ophthalmology, Nagoya City Univ 

Medical School, Nagoya, Japan 

4021 — 9:45 Recombinant Human Nerve 

Growth Factor Protects Photoreceptor 

Degeneration in a Rat Model of Inherited 

Retinitis Pigmentosa. Luigi Aloe 1 , P. Bianchi 1 , 

M. Rocco 1 , A. Micera 2 , A. Lambiase 3 , S. Bonini 3 . 

1 

Institute of Neurobiology and Molecular Medicine, 

National Research Council, Rome, Italy; 2 G.B. 

Bietti IRCCS, Rome, Italy; 3 Department of 

Ophthalmology, University of Rome, Campus 

Biomedico, Rome, Italy *CR 

Wednesday Papers/ 

Minisymposium 

8:30 am – 10:15 am 

f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 

269

4022 – 4039 – Wednesday – Papers/Minisymposium 


Minisymposium 

8:30 am – 10:15 am 

4022 — 10:00 Nonsyndromic RP Due to BBS2 

Mutations. Meghan J. Marino 1 , G. J. Pauer 1 , 

J. Chiang 3 , S. A. Hagstrom 1, 2 , E. I. Traboulsi 1, 2 . 

1 

Ophthalmic Research, Cole Eye Institute, 

Cleveland Clinic, Cleveland, OH; 2 Ophthalmology, 

Cleveland Clinic Lerner College of Medicine Case 

Western Reserve University, Cleveland, OH; 3 Casey 

Eye Institute Molecular Diagnostics Laboratory, 

Portland, OR *CR 

6E 


Retina 

404 DR: Therapeutic Effects 

Moderator: Peter A. Campochiaro 

4023 — 8:30 Intravitreal ranibizumab (RBZ) 

suppresses posterior retinal nonperfusion (RNP) 

in patients with diabetic macular edema (DME). 

Peter A. Campochiaro 1 , C. Wykoff 2 , D. Chen 3 , H. 

Shapiro 4 , J. S. Ehrlich 5 , R. Rubio 6 . 1 Ophthalmology 

and Neuroscience, Johns Hopkins Wilmer Eye 

Inst, Baltimore, MD; 2 Retina Consultants of 

Houston, Houston, TX; 3 Genentech, Inc., South 

San Francisco, CA; 4 Genentech, Inc., South 

San Francisco, CA; 5 Genentech, Inc., South San 

Francisco, CA; 6 Genentech, Inc., South San 

Francisco, CA *CR, f 

4024 — 8:45 Intensive Diabetes Therapy 

Reduces Ocular Surgeries in Patients with 

Type 1 Diabetes: twenty-eight year followup of 

the Diabetes Control and Complications Trial 

/ Epidemiology of Diabetes Interventions and 

Complications study (DCCT/EDIC). Lloyd P. 

Aiello 1, 2 , W. Sun 5 , P. A. Cleary 5 , J. M. Lachin 5 , 

S. Gangaputra 3 , R. Klein 4 , A. Das 7 , S. Kiss 6 , A. 

Domalpally 3 , R. P. Danis 3 . 1 Beetham Eye Institute, 

Joslin Diabetes Center, Boston, MA; 2 Department 

of Ophthalmology, Harvard Medical School, 

Boston, MA; 3 Fundus Photograph Reading Center, 

University of Wisconsin, Madison, WI; 4 Department 

of Ophthalmology and Visual Sciences, University 

of Wisconsin School of Medicine and Public 

Health, Madison, WI; 5 Biostatistics Center, George 

Washington University, Rockville, MD; 6 Clinical 

Research, Weill Cornell Medical College, New 

York, NY; 7 University of New Mexico School of 

Medicine, Albuquerque, NM *CR, f 

4025 — 9:00 Canadian PhIIIb study: 

ranibizumab combination/monotherapy in visual 

impairment due to DME: Preliminary Analysis. 

Thomas Sheidow 1, 2 , A. R. Berger 3 , F. deTakacsy 4 , 

R. Li 4 , B. Rehel 5 , A. Courseau 4 . 1 Ivey Eye Institute, 

London, ON, Canada; 2 Ophthalmology, Western 

University, London, ON, Canada; 3 St. Michael’s 

Hospital, Toronto, ON, Canada; 4 Novartis 

Pharmaceuticals Canada Inc., Dorval, QC, Canada; 

5 

Everest Clinical Research Services, Inc., Markham, 

ON, Canada *CR, f 

4026 — 9:15 Baseline Predictors of 

improvement in self-reported visual function 

following treatment with ranibizumab in patients 

with diabetic macular edema. Rohit Varma 1 , N. 

M. Bressler 2 , C. Dolan 3 , L. Yau 3 , J. F. Ward 3 , S. 

Colman 3 . 1 Ophthalmology and Visual Sciences, 

University of Illinois at Chicago Eye and Ear 

Infirmary, Chicago, IL; 2 Retina Division, Wilmer 

Eye Institute, Johns Hopkins University School of 

Medicine, Baltimore, MD; 3 Genentech, Inc., South 

San Francisco, CA *CR, f 

4027 — 9:30 Effect of Statins and Diabetes 

Therapy (Oral Hypoglycemics and Insulin) 

on the Outcomes of Patients Treated with 

Ranibizumab and/or Laser Therapy. Mohammad 

A. Sadiq 1 , M. Hassan 1 , Y. J. Sepah 1 , G. K. Loh 2, 1 , S. 

Kherani 1 , M. Hanout 1 , R. E. Annam 1 , M. Ansari 1 , 

D. V. Do 1 , Q. Nguyen 1 . 1 Retinal Imaging Research 

and Reading Center, Wilmer Eye Institute. Johns 

Hopkins University, Baltimore, MD; 2 Division 

of medicine, University College London Medical 

School, London, United Kingdom *CR, f 

4028 — 9:45 Effects of Intravitreal 

Ranibizumab on Diabetic Retinopathy Severity: 

36 Month Data from the RISE and RIDE Phase 

III Trials. Jason S. Ehrlich 1 , A. Domalpally 2 , 

L. Yau 1 , J. J. Hopkins 1 , M. S. Ip 2 . 1 Genentech, 

Inc, South San Francisco, CA; 2 Department of 


Wisconsin Medical School, Madison, WI *CR, f 

4029 — 10:00 RELIGHT - Ranibizumab 

treatment of diabetic macular oedema with 

bimonthly monitoring after a phase of initial 

Treatment. Ian A. Pearce. Royal Liverpool 

University Hospital, St Paul’s Eye Unit, Liverpool, 

United Kingdom *CR, f 

606/607 


Immunology/Microbiology / Cornea 

405 Host Responses to Ocular 

Herpesvirus Infection - What Have 

We Learned and What Is the Future 

Direction? - Minisymposium 

This session will cover current data and concepts 

from clinical presentation, immune response/ 

regulation to virus infection, and development of 

novel treatment strategies. 

Moderators: Daniel J. Carr and Barry T. Rouse 

4030 — 8:30 Insights into Natural History 

of HSV Infections in the Era of Changing 

Epidemiology. Anna Wald. University of 

Washington, Seattle, WA *CR 

4031 — 9:00 Herpes Simplex Virus Evasion of 

Host Immunity and the Autophagy Response. 

David A. Leib. Microbiology and Immunology HB 

7556, Dartmouth Medical School, Lebanon, NH 

4032 — 9:20 Chronic Murine Cytomegalovirus 

Infection results in more severe Experimental 

Choroidal Neovascularization. Richard D. Dix. 

Department of Biology, Georgia State University, 

Atlanta, GA 

The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index. 

270 

4033 — 9:40 Pathogenesis of Herpes 

Stromal Keratitis - A Focus on Corneal 

Neovascularization. Barry T. Rouse. Pathobiology, 

Univ of Tennessee Coll of Vet Med, Knoxville, TN 

4034 — 10:00 Discussion. Todd P. Margolis. 

UCSF Proctor Foundation, Univ of California-San 

Francisco, San Francisco, CA *CR 

608 


Anatomy/Pathology 

406 Myopia and Emmetropization 

Moderators: Frank Schaeffel and Chi-ho To 

4035 — 8:30 Distribution and Determinants 

of Eye Size and Shape in Newborn Children: 

a Magnetic Resonance Imaging Analysis. 

Laurence S. Lim 1, 2 , P. Tan 2 , G. Chong 2 , Y. Chong 2 , 

M. V. Fortier 3 , P. Gluckman 4, 5 , S. Saw 2, 1 , A. Qiu 2 . 

1 

Ophthalmology, Singapore National Eye Center, 

Singapore, Singapore; 2 National University of 

Singapore, Singapore, Singapore; 3 KK Women’s 

and Children’s Hospital, Singapore, Singapore; 

4 

Singapore Institute for Clinical Sciences, the 

Agency for Science, Technology and Research, 

Singapore, Singapore; 5 Liggins Institute, University 

of Auckland, Auckland, New Zealand *CR 

4036 — 8:45 Central retinal thickness and 

axial length in the Copenhagen Child Cohort 

2000 study: data from 432 11-year-old children. 

Xiao Q. Li 1 , M. Larsen 1 , I. C. Munch 2 . 1 Department 

of Ophthalmology, Glostrup Hospital, Glostrup, 

Denmark; 2 Department of Ophthalmology, Roskilde 

Hospital, Roskilde, Denmark 

4037 — 9:00 Neurochemical Ablation of 

Peripheral Glucagonergic Amacrine Cells in 

the Chick Retina and its Effects on Axial Eye 

Growth and Refractive Error. Diane Nava 1, 2 , A. 

Chang 2 , L. A. Ostrin 2 , Z. Chen 2, 3 , C. F. Wildsoet 1, 2 . 

1 

Vision Science Group, UC Berkeley, Berkeley, 

CA; 2 Center for Eye Disease and Development, 

UC Berkeley School of Optometry, Berkeley, CA; 

3 

Department of Opthalmology and Vision Science, 

Fudan University Eye and ENT Hospital, Shanghai, 

China 

4038 — 9:15 Ocular growth guided by dual 

focal fresnel lenses requires an intact optic 

nerve. Sally A. McFadden 1 , D. Y. Tse 2 , C. To 2 , C. 

F. Wildsoet 3 . 1 School of Psychology, University of 

Newcastle, Callaghan, NSW, Australia; 2 School of 

Optometry, The Hong Kong Polytechnic University, 

Kowloon, Hong Kong; 3 School of Optometry, 

University of California, Berkeley, CA 

4039 — 9:30 Effects of Long-Wavelength- 

Pass Filters on Refractive Development in 

Rhesus Monkeys. Earl L. Smith 1, 2 , L. Hung 1, 2 , 

B. Arumugam 1, 2 , J. Huang 1, 2 , M. Neitz 3 , J. Neitz 3 . 

1 

College of Optometry, University of Houston, 

Houston, TX; 2 Vision Cooperative Research 

Centre, Sydney, NSW, Australia; 3 Department of 

Ophthalmology, University of Washington Medical 

School, Seattle, WA *CR

4040 — 9:45 The role of central retina in 

chicks during form deprivation myopia. Jianchao 

Wang 1, 2 , R. Chun 1 , K. Li 1 , Q. Liu 1, 2 , C. To 1, 2 . 

1 

Laboratory of Experimental Optometry, Centre 

for Myopia Research, School of Optometry, The 

Hong Kong Polytechnic University, HongKong, 

China; 2 State Key Laboratory of Ophthalmology, 

Zhongshan Ophthalmic Centre, Sun Yat-sen 

University, Guangzhou, China 

4041 — 10:00 Photoreceptor Outer Retinal 

Function as the Primary Controller of Ocular 

Growth. David P. Crewther 1, 2 , S. N. Kiely 2 , M. 

J. Murphy 2 , N. Riddell 2 , S. G. Crewther 2 . 1 Centre 

for Human Psychopharmacology, Swinburne 

Univ of Technology, Melbourne, VIC, Australia; 

2 

Psychological Science, La Trobe University, 

Melbourne, VIC, Australia 

4048 — 10:00 Linking the optical properties of 

the lens to its cellular physiology: a multimodal 

imaging and modelling approach. Ehsan Vaghefi 

Rezaei 1 , A. Kim 1 , P. J. Donaldson 2, 1 . 1 Department 

of Optometry and Vision Sciences, University 

of Auckland, Auckland, New Zealand; 2 School 

of Medical Sciences, University of Auckland, 

Auckland, New Zealand 

611-614 


Retinal Cell Biology 

408 Differentiation of Stem and 

iPS Cells 


4054 — 9:45 Investigating the pathophysiology 

of USH2A associated retinal degeneration with 

patient specific iPSCs. Budd A. Tucker 1 , R. F. 

Mullins 1 , K. R. Anfinson 1 , L. M. Affatigato 1 , J. 

A. Halder 1 , P. M. Brzeskiewicz 1 , E. M. Stone 1, 2 . 

1 

Ophthalmology, Inst for Vision Rsrch, Univ of 

Iowa, Iowa City, IA; 2 HHMI Investigator, Iowa 

City, IA *CR 

4055 — 10:00 Differentiation of iPS-RPE 

cells from a patient with clinical anophthalmia. 

Amanda-Jayne F. Carr 1 , L. Ho 2 , L. Chen 1 , G. Selva 

Raj 2 , A. A. Vugler 1 , M. A. Shboul 2 , A. Colman 2 , 

B. Reversade 2 , P. J. Coffey 1 . 1 Division of ORBIT, 

Institute of Ophthalmology, University College 

London, London, United Kingdom; 2 Dept. of 

Paediatrics, A*STAR Institute of Medical Biology, 

Biopolis, Singapore 

609 


Lens 

407 Cell Biology Impacts 

Lens Function 

Moderators: Marc Kantorow and A S. Menko 

4042 — 8:30 JNK inactivation suppresses 

mTOR (Mammalian Target of Rapamycin) 

pathway to induce loss of nuclei and organelles 

in the lens through Autophagy. Subhasree Basu 1 , 

S. Rajakaruna 1 , B. A. Reyes 2 , E. J. Van Bockstaele 2 , 

A. S. Menko 1, 3 . 1 Pathology Anatomy & Cell 

Biology, Thomas Jefferson University, Philadelphia, 

PA; 2 Neuroscience, Thomas Jefferson University, 

Philadelphia, PA; 3 Wills Vision Research Center at 

Jefferson, Philadelphia, PA 

4043 — 8:45 Autophagy mediates 

mitochondrial degradation in the developing 

and adult eye lens. Marc Kantorow 1 , D. Chauss 1 , 

A. Mohamed 2 , K. Gilliland 3 , L. A. Brennan 1 , M. J. 

Costello 3 . 1 Biomedical Sciences, Florida Atlantic 

University, Boca Raton, FL; 2 L. V. Prasad Eye 

Institute, Hydrabad, India; 3 Cell Biology and 

Physiology, University of North Carolina, Chapel 

Hill, NC 

4044 — 9:00 Loss of Pten Rescues Akt 

Phosphorylation, Apoptosis and Size in Fgfr2 

Deficient Lenses. Blake R. Chaffee, M. R. Leonard, 

B. D. Wagner, M. L. Robinson. Zoology, Miami 

University, Oxford, OH 

4045 — 9:15 Role of Birc7 in the Mouse Lens. 

Alicia De Maria, S. Bassnett. Ophthalmology and 

Visual Sciences, Washington University, St Louis, 

MO 

4046 — 9:30 The Optical Quality of Inhibitor- 

Treated Avian Crystalline Lenses. Gah-Jone 

Won, V. Choh. School of Optometry, University of 

Waterloo, Waterloo, ON, Canada 

4047 — 9:45 Estimation of Ciliary Muscle 

Forces Required to Induce Corneal Deformation. 

Robert P. Wilkes, M. A. Reilly. Biomedical 

Engineering, University of Texas at San Antonio, 

San Antonio, TX 

Moderators: Jason S. Meyer and G Astrid Limb 

4049 — 8:30 MITF regulation of early cell fate 

in a human embryonic stem cell model of retinal 

development. Elizabeth E. Capowski 1 , J. Simonett 1 , 

E. Clark 1 , L. S. Wright 1 , I. Pinilla Lozano 2, 3 , J. 

Phillips 1 , K. Wallace 1 , D. M. Gamm 4, 5 . 1 Waisman 

Center, University of Wisconsin-Madison, Madison, 

WI; 2 Ophthamology, University Hospital Lozano 

Blesa, Zaragoza, Spain; 3 IIS Aragon, Aragon Health 

Sciences Institute, Zaragoza, Spain; 4 Ophthamology 

and Visual Sciences, University of Wisconsin- 

Madison, Madison, WI; 5 McPherson Eye Research 

Institute, University of Wisconsin-Madison, 

Madison, WI *CR 

4050 — 8:45 Simplified and Efficient 

Generation of Photoreceptors from Human 

Pleuripotent Stem Cells. Joo Young Shin, H. Yu. 

Ophthalmology, Seoul National University, Seoul, 

Republic of Korea 

4051 — 9:00 Improving Human RPE 

Differentiation from iPS Cells: Lessons from 

Mouse Eye Development. Kapil Bharti 1 , J. 

Davis 1 , B. Corneo 2 , Q. Wan 1 , K. J. Miyagishima 1 , 

S. Temple 2 , S. S. Miller 1 . 1 NEI, National Institutes 

of Health, Bethesda, MD; 2 National Eye Institute, 

National Institutes of Health, Bethesda, MD *CR 

4052 — 9:15 Investigating the role of VSX2 

(CHX10) in human retinogenesis using iPS cells. 

Joe Phillips 1, 2 , E. Perez 1 , K. Wallace 1 , J. M. Martin 1 , 

R. Singh 1 , E. E. Capowski 1 , L. S. Wright 1 , E. Clark 1 , 

E. F. Percin 3 , D. M. Gamm 1, 2 . 1 Waisman Center, 

University of Wisconsin, Madison, WI; 2 McPherson 

Eye Research Institute, University of Wisconsin, 

Madison, WI; 3 Medical Genetics, Gazi University, 

Ankara, Turkey *CR 

4053 — 9:30 Differentiation of Human 

Protein Induced Pluripotent Stem Cells (piPS) 

Towards a Retinal Pigment Epithelium (RPE) 

Fate. Jie Gong, M. A. Fields, L. V. Del Priore. 

Ophthalmology, MUSC Storm Eye Institute, 

Charleston, SC 

618-620 


Physiology/Pharmacology / Cornea / 


409 Purine Signaling in the Eye: Role 

in Health and Disease - Minisymposium 

The field of purine signaling is rapidly expanding, 

with a great diversity of roles in health and 

disease. Purine receptors (P1 Adenosine and P2 

Purine/Nucleotide receptors) have been identified 

throughout the tissues of the eye with proposed 

roles in processes including control of intraocular 

pressure, visual processing and mediation of 

inflammatory responses. This symposium explores 

purine signaling in ocular tissues: lacrimal gland, 

trabecular meshwork, lens and retina. Questions 

are asked about the role of purine signaling in 

healthy ocular tissue, including in development 

and in retinal processing, as well as addressing the 

consequences of dysregulation to ocular health in 

disease, including dry eye and glaucoma. Purine 

receptors as putative drug targets for ocular disease 

are also discussed. 

Moderators: Julie Sanderson, Claire H. Mitchell 

and Claudio Bucolo 

4056 — 8:30 Introduction to Purine Signaling. 

Julie Sanderson. School of Pharmacy, University of 

East Anglia, Norwich, United Kingdom 

4057 — 8:45 Purine Signaling in the 

Trabecular Meshwork: A Regulator of 

Intraocular Pressure. Mortimer M. Civan. 

Physiology-Richards Bldg, Univ of Pennsylvania 

Sch of Med, Philadelphia, PA 

4058 — 9:00 Purinergic Receptors in Lacrimal 

Gland Health and Dry Eye Disease. Darlene A. 

Dartt. Schepens Eye Research Institute, Boston, 

MA 

4059 — 9:15 TRPV4 and Hemichannels 

Cooperate to Play a Critical Role in Purine 

Signaling in the Lens. Nicholas A. Delamere. 

Physiology, University of Arizona, Tucson, AZ 


Minisymposium 

8:30 am – 10:15 am 


271


4060 — 9:30 Purine Signaling in Müller 

Cells During Development and in the Adult 

Retina in Health and Disease. Antje Grosche. 

Pathophysiology of Neuroglia, University of 

Leipzig, Leipzig, Germany 

4061 — 9:45 Purinergic Signaling in Retinal 

Processing. Thomas E. Salt. Visual Neuroscience, 

UCL Institute of Ophthalmology, London, United 

Kingdom *CR 

4062 — 10:00 Purines and Low Grade 

Inflammation at Either End of the Retina; ATP 

and Cytokines in Both RGCs and RPE. Claire H. 

Mitchell. Anatomy and Cell Biology, University of 

Pennsylvania Library, Philadelphia, PA *CR 

TCC LL 4/5 


Visual Psychophysics / Physiological Optics 

410 Spatial Vision, Visual 

Psychophysics and Aging II 

TCC 303 


Cornea 

411 Keratoconus and Biomechanics 

Moderator: Shukti Chakravarti 

4069 — 8:30 Mutations in the zinc finger 

protein gene, ZNF469 contribute to the 

pathogenesis of keratoconus. Andrea L. Vincent 1, 2 , 

C. Jordan 1, 2 , B. Hay 1 , A. J. Richards 1 , C. N. 

McGhee 1, 2 . 1 Ophthalmology, New Zealand National 

Eye Centre, University of Auckland, Auckland, 

New Zealand; 2 Eye Department, Greenlane Clinical 

Centre, Auckland District Health Board, Auckland, 

New Zealand *CR 

4070 — 8:45 Matrix Metalloproteinase-9 drives 

disease progression of Keratoconus. Ashwini 

Ranganath, R. Shetty, S. D’Souza, K. Wadia, D. 

Das, A. Ghosh. cornea and refractive surgery, 

Narayana Nethralaya eye hospital, Bangalore, India 

f 

4071 — 9:00 Novel proteins and metabolites 

for the identification of Keratoconus disease. 

Dimitrios Karamichos 1, 2 , J. Hjortdal 4 , A. E. 

Hutcheon 1, 2 , J. M. Asara 3 , J. D. Zieske 1, 2 . 

1 

Schepens Eye Research Institute/MEE, Boston, 

MA; 2 Department of Ophthalmology, Harvard 

Medical School, Boston, MA; 3 Division of 

Signal Transduction/Mass Spectrometry Core, 

Beth Israel Deaconess Medical Center, Harvard 

Medical School, Boston, MA; 4 Department of 

Ophthalmology, Aarhus University Hospital, Aarhus 

C, Denmark *CR 

4072 — 9:15 Evaluation of transcorneal 

iontophoresis of riboflavin for corneal 

collagen cross-linking. Alejandro Arboleda 1, 2 , L. 

Kowalczuk 3 , M. Savoldelli 4 , C. Klein 3 , S. Ladraa 3 , 

J. A. Parel 1, 4 , F. F. Behar-Cohen 3, 4 . 1 Ophthalmic 

Biophysics Center, Dept. of Ophthalmology, 

Bascom Palmer Eye Institute, University of 

Miami Miller School of Medicine, Miami, FL; 

2 

Dept. of Biomedical Engineering, University 

of Miami College of Engineering, Coral Gables, 

FL; 3 INSERM UMRS872: Physiopathology of 

Ocular Diseases: Therapeutic Innovations, Centre 

de Recherche des Cordeliers, Pierre et Marie 

Curie University, Paris Descartes University, 

Paris, France; 4 AP-HP Hôtel-Dieu, Dept. of 

Ophthalmology, Sorbonne Paris Cité, Paris 

Descartes University, Faculty of Medicine, Paris, 

France *CR 

4073 — 9:30 Corneal biomechanical 

properties in corneal collagen cross-linking 

(CXL) at high fluences. Arthur Hammer 1 , O. 

Richoz 1 , D. Tabibian 1 , F. Hoogewoud 1 , F. Hafezi 1, 2 . 

1 

Ophthalmology, Geneva University Hospitals, 

Geneva, Switzerland; 2 Ophthalmology, Doheny 

Eye Institute, Keck school of medicine USC, Los 

Angeles, CA *CR 

4074 — 9:45 Soluble collagen protects the 

corneal fibrils during riboflavin crosslinking. 

Marcos Garza-Madrid 1, 2 , J. Elisseeff 1 . 

1 

Translational Tissue Engineering Center, Wilmer 

Eye Institute, Johns Hopkins School of Medicine, 

Baltimore, MD; 2 Ophthalmology and Visual 

Sciences Research Chair, School of Medicine 

and Health Sciences, Tecnológico de Monterrey, 

Monterrey, Mexico *CR 

4075 — 10:00 Brillouin microscopy of 

collagen crosslinking: non-contact depthdependent 

analysis of corneal elastic modulus. 

Giuliano Scarcelli 1 , S. Kling 2 , E. Quijano 1 , R. 

Pineda 3 , S. Marcos 2 , S. H. Yun 1 . 1 Wellman Center 

for Photomedicine, Harvard Medical School, 

Cambridge, MA; 2 Instituto de Optica, Conjejo 

Superior de investigation cientifica, Madrid, Spain; 

3 

Ophthalmology, Mass eye and ear Infirmary, 

Boston, MA *CR 

TCC 304 


Visual Neuroscience 

412 Photoreceptors: Structure, 

Transduction, Signaling 


Minisymposium 

8:30 am – 10:15 am 

Moderators: Joanne M. Wood and Heidi J. Hofer 

4063 — 8:30 Two-point detection and 

appearance in the absence of higher order 

aberrations. Heidi J. Hofer, D. E. Koenig. College 

of Optometry, University of Houston, Houston, TX 

4064 — 8:45 A Comparison of Acuity and 

Cone Density in the Temporal Retina. Nancy J. 

Coletta 1 , T. Y. Chui 2 , A. E. Elsner 2 . 1 Vision Science, 

New England College of Optometry, Boston, 

MA; 2 School of Optometry, Indiana University, 

Bloomington, IN *CR 

4065 — 9:00 Age-related variation in foveal, 

parafoveal and peripheral spatial suppression. 

Rigmor C. Baraas, C. Aaen-Stockdale, S. J. Gilson. 

Optometry & Visual Science, Buskerud University 

College, Kongsberg, Norway 

4066 — 9:15 Heterochromatic Modulation 

Photometry can be used to measure Macular 

Pigment Optical Density. Cord R. Huchzermeyer 1 , 

J. Schlomberg 1 , U. Welge-Lüssen 1 , T. Berendschot 2 , 

J. J. Kremers 1 . 1 Department of Ophthalmology, 

University Erlangen-Nuremberg, Erlangen, 

Germany; 2 University Eye Clinic, Maastricht, 

Netherlands 

4067 — 9:30 Comparability of Visual 

Performance of Individuals with Low Vision in 

Real and Virtual Street Intersections. Lei Liu, 

E. L. Bowman. School of Optometry, University of 

Alabama at Birmingham, Birmingham, AL 

4068 — 9:45 Optical quality and subjective 

judgments of blur under pure simultaneous 

vision. Carlos Dorronsoro, A. Radhakrishnan, L. 

Sawides, S. Marcos. Instituto de Optica, CSIC, 

Madrid, Spain *CR 

Moderators: Marie E. Burns and Wolfgang Baehr 

4076 — 8:30 Modulating the phototransduction 

cascade with small molecules. Tomoki Isayama 1 , 

J. Wu 1 , S. Miyazono 1 , V. Lee 1 , E. S. Levine 1 , E. 

Makino 3 , A. L. Zimmerman 2 , C. L. Makino 1 . 

1 

Ophthalmology, Mass Eye & Ear Infirmary, 

Boston, MA; 2 Molecular Pharmacology, Physiology 

and Biotechnology, Brown University, Providence, 

RI; 3 LGCR, Sanofi Corporation, Waltham, MA 

4077 — 8:45 Under-expression of GAP 

proteins: Effect on Mouse Rod Response Decay. 

Gordon L. Fain 1, 2 , M. L. Woodruff 1 , C. J. Chen 3 . 

1 

Integrative Biology and Physiology, Univ of 

California-Los Angeles, Los Angeles, CA; 2 Jules 

Stein Eye Institute, UCLA, Los Angeles, CA; 

3 

Biochemistry and Molecular Biology, Virginia 

Commonwealth University, Richmond, VA 

4078 — 9:00 Light-induced translocation 

of RGS9-1 and Gβ5L in Mouse Rod 

Photoreceptors. You-Wei Peng 1 , M. Tian 1 , M. L. 

Zallocchi 1 , W. Wang 1 , C. J. Chen 2 , K. Palczewski 3 , 

D. E. Cosgrove 1 . 1 Genetics, Boys Town Natl 

Research Hosp, Omaha, NE; 2 Biochemistry & 

Molecular Biology, Virginia Commonwealth 

University, Richmond, VA; 3 Pharmacology, Case 

Western Reserve University, Cleveland, OH *CR 

4079 — 9:15 Complete protein composition of 

the photoreceptor disc identified by label-free 

quantitative proteomics. Nikolai P. Skiba, V. Y. 

Arshavsky. Duke University, Durham, NC 

4080 — 9:30 Molecular Function of 

Peripherin-2/rds for Photoreceptor Membrane 

Structure. Andrew F. Goldberg, N. Khattree, L. M. 

Ritter. Eye Research Institute, Oakland University, 

Rochester Hills, MI 


272


4081 — 9:45 Bleach-Induced Desensitization 

and Response Compression of the Photocurrent 

and Photovoltage in Mouse Rods. Johan 

Pahlberg 1 , R. Frederiksen 2 , K. J. Miyagishima 1 , S. 

Nymark 2 , A. P. Sampath 1 , M. C. Cornwall 2 . 1 Zilkha 

Neurogenetic Institute, University of Southern 

California, Los Angeles, CA; 2 Boston University 

Medical School, Department of Physiology and 

Biophysics, Boston, MA 

4082 — 10:00 Phosphoinositides and 

membrane trafficking in zebrafish cone inner 

segments. Sara Hayden, S. E. Brockerhoff. 

Biochemistry, University of Washinton, Seattle, WA 


Minisymposium 

8:30 am – 10:15 am 


273

4083 – 4105 – Wednesday – Posters 

Wednesday Posters 

8:30 am – 10:15 am 

Exhibit Hall A0001-A0047 


Retina 

413 AMD II, RE 

Moderators: David R. Hinton and Diana V. Do 

4083 — A0001 Pars Plana Vitrectomy, 

Subretinal Injection of Recombinant Tissue 

Plasminogen Activator and Intraocular Gas 

Tamponade for Thick Submacular Hemorrhage 

with Polypoidal Choroidal Vasculopathy. 

Woohyok Chang, C. Cho, M. Sagong, H. Oh, J. 

Park, D. Park, M. Kim, W. Gu, J. Son. Department 

of Ophthalmology, Yeungnam Univ College of 

Medicine, Daegu, Republic of Korea 

4084 — A0002 The Effects of Docosahexaenoic 

Acid (DHA) Dietary Supplementation on Retinal 

Lipid Profile in a Mouse Model of Stargardt-like 

Macular Dystrophy (STGD3). Mandy Hong 1 , S. 

Kuny 1 , R. Bryant 1 , F. Gaillard 1 , M. Suh 2 , Y. Sauve 1 . 

1 

Ophthalmology, University of Alberta, Edmonton, 

AB, Canada; 2 Human Nutritional Sciences, 

University of Manitoba, Winnipeg, MB, Canada 

4085 — A0003 In vivo Evaluation of Surface 

Modified Expanded-polytetrafluroethylene 

(ePTFE) Substrate as a Permanent Substrate 

for Cell Transplantation. Shen Nian 1 , Z. Fu 1 , C. 

M. Sheridan 3 , V. Kearns 3 , R. Williams 3 , S. Wong 1 , 

K. Vasilev 4 , A. Bachhuka 4 , A. C. Lo 1, 2 , W. W. Lai 1 . 

1 

Ophthalmology, University of Hong Kong, Hong 

Kong, Hong Kong; 2 Research Centre of Heart, 

Brain, Hormone and Healthy Aging, University of 

Hong Kong, Hong Kong, Hong Kong; 3 Eye and 

Vision Science, University of Liverpool, Liverpool, 

United Kingdom; 4 Mawson Institute and School 

of Advanced Manufacturing, University of South 

Australia, Mawson Lakes, SA, Australia 

4086 — A0004 Prevalence of Subretinal 

Drusenoid Deposits in Age-Related Macular 

Degeneration with Newly Diagnosed Choroidal 

Neovascularization. Sandrine A. Zweifel, R. A. 

Rieder, M. M. Kohler, R. Gambon. Department of 

Ophthalmology, University Hospital Zurich, Zurich, 

Switzerland 

4087 — A0005 Autofluorescence and OCT of 

Retinal pigment epithelial tears. Naoto Hanyuda, 

T. Sato, R. Mukai, S. Kishi. Gunma University, 

Maebashi, Japan *CR 

4088 — A0006 Anatomic patterns and clinical 

presentation of recurrence in ‘stable’ wet Age 

Related Macular Degeneration (AMD) patients. 

Fani Zacharaki, M. N. Chandran, N. Nair, P. 

Vijayakumar, G. Menon. Frimley Park Hospital 

NHS Foundation Trust, Frimley, United Kingdom 

*CR 

4089 — A0007 Detection and Quantification 

of Autofluorescence Abnormalities in Patients 

with Neovascular Macular Degeneration using 

a Fully Automated Image Analysis Algorithm. 

Kathryn L. Pepple, Q. Nie, S. S. Ong, S. W. Cousins. 

Ophthalmology, Duke Eye Center, Durham, NC 

*CR 

4090 — A0008 Ranibizumab Leads to 

Regression or Elimination of Choroidal 

Neovascular Membranes in Most Eyes with 

AMD: A HARBOR Subanalysis. Nikolas J. 

London 1 , P. E. Tornambe 1 , L. Yau 2 , J. A. Nau 2 , L. 

Tuomi 2 . 1 Retina Consultants San Diego, San Diego, 

CA; 2 Genentech Inc., South San Francisco, CA 

*CR, f 

4091 — A0009 Anti-VEGF Gene Therapy for 

Wet AMD: Phase I/II Safety and Pharmacology 

Results. Elizabeth P. Rakoczy 1, 2 , M. Lai 1, 2 , 

C. Pierce 2 , A. L. Magno 2 , R. Samulski 3 , T. W. 

Chalberg 4 , M. S. Blumenkranz 5 , I. Constable 1, 2 . 

1 

Centre for Ophthalmology and Visual Sciences, 

The University of Western Australia, Perth, WA, 

Australia; 2 Molecular Ophthalmology, Lions Eye 

Institute, Perth, WA, Australia; 3 Gene Therapy 

Centre, University of North Carolina, Chapel Hill, 

NC; 4 Avalanche Biotechnologies, San Francisco, 

CA; 5 Byers Eye Institute at Stanford, Palo Alto, CA 

*CR, f 

4092 — A0010 Polypoidal choroidal 

vasculopathy in Caucasian patients. Stephen 

Davis, A. Lauer, C. J. Flaxel. Oregon Health and 

Science University, Casey Eye Institute, Portland, 

OR *CR 

4093 — A0011 Baseline characteristics and 

response to intravitreal ranibizumab therapy for 

age-related macular degeneration. Misa Suzuki, 

N. Nagai, K. Izumi-Nagai, H. Shinoda, T. Koto, 

A. Uchida, H. Mochimaru, K. Yuki, K. Tsubota, Y. 

Ozawa. Ophthalmology, Keio University School of 

Medicine, Tokyo, Japan *CR, f 

4094 — A0012 Disease Activity in Disciform 

Scars due to Age-Related Macular Degeneration 

(AMD). Deborah Witkin 1 , J. B. Sanderson 1 , D. 

Ferrara 2, 1 , E. Reichel 1 . 1 Ophthalmology, Tufts 

Medical Center, Boston, MA; 2 Digital Angiography 

Reading Center DARC, Great Neck, NY *CR 

4095 — A0013 The Incidence of Neovascular 

Subtypes in Newly Diagnosed Wet Age-Related 

Macular Degeneration. Jesse J. Jung 1, 3 , L. 

Xu 2, 5 , R. Gallego-Pinazo 2, 4 , S. Mrejen 2, 3 , M. 

Marsiglia 2, 3 , S. Boddu 1 , K. Freund 1, 2 . 1 Department 

of Ophthalmology, New York Univ School of 

Med, New York, NY; 2 Vitreous Retina Macula 

Consultants of New York, New York, NY; 3 LuEsther 

T. Mertz Retinal Research Center, Manhattan 

Eye, Ear, and Throat Hospital, New York, NY; 

4 

Department of Ophthalmology, University and 

Polytechnic Hospital La Fe, Valencia, Spain; 5 St. 

Vincent’s Medical Center, Bridgeport, CT *CR 

4096 — A0014 Choroidal thickness change 

following intravitreal bevacizumab therapy 

for wet age-related macular degeneration: Six 

months results. Sharif Y. El Emam, G. Barteselli, J. 

Chhablani, S. Lee, I. Kozak, L. Cheng, W. Freeman. 

Ophthalmology, Shiley Eye Center, UCSD, La 

Jolla, CA *CR 

4097 — A0015 The Relationship of Choroidal 

Thickness to Scotopic Sensitivity in Agerelated 

Macular Degeneration (AMD). Karl G. 

Csaky 1, 3 , D. G. Birch 1, 2 , R. Gelman 1 , J. Felius 1 . 

1 

Ophthalmology, Retina Foundation of the 

Southwest, Dallas, TX; 2 Ophthalmology, University 

of Texas Southwestern Medical Center, Dallas, TX; 

3 

Texas Retina Associates, Dallas, TX *CR 

4098 — A0016 Choroidal Thickness 

following Anti-Vascular Endothelial Growth 

Factor Therapy for Neovascular Age-Related 

Macular Degeneration. Charlotte So, Z. Ravage. 

Ophthalmology, Rush University Medical Center, 

Chicago, IL 

4099 — A0017 Correlation Between Changes 

in Subfoveal Choroidal Thickness and 1-Year 

Outcomes of Ranibizumab Therapy for 

Polypoidal Choroidal Vasculopathy. Taiichi 

Hikichi, H. Kitamei, S. Shioya, M. Higuchi, T. 

Matsushita, S. Kosaka, R. Matsushita, K. Takami, 

H. Ohtsuka. Ohtsuka Eye Hospital, Sapporo, Japan 

4100 — A0018 Axial Length and Subfoveal 

Choroidal Thickness in Individuals with Agerelated 

Macular Degeneration (AMD). Chih 

Ping Wang 1, 2 , C. Lai 1, 2 , J. Huang 1, 2 , C. Kuo 1, 2 . 

1 

Department of Ophthalmology, Chang Gung 

Memorial Hospital, Chiayi, Chiayi County, Taiwan; 

2 

Chang Gung University, Taoyan, Taiwan 

4101 — A0019 APE1/Ref-1 redox inhibitor 

APX3330 modulates choroidal endothelial cells 

by transcriptional regulation of NF-κB and 

STAT3 activity. Xiaoxi Qiao 1 , Y. Li 1 , X. Liu 1 , T. 

Zhou 1 , M. R. Kelley 2 , P. A. Edwards 1 , H. Gao 1 . 

1 

Ophthalmology, Henry Ford Health System, 

Detroit, MI; 2 Herman B Wells Center for Pediatric 

Research, Indiana University School of Medicine, 


4102 — A0020 Apolipoprotein mimetic Dual 

Domain Peptide reduces Neutral Lipid Deposits 

in murine Bruch’s Membrane. Armin Mohi, S. 

Grisanti, M. Rudolf. Department of Ophthalmology, 

University of Luebeck, Luebeck, Germany *CR 

4103 — A0021 Identification of Human 

Macular Tissue Antigens Recognized by Serum 

Auto-Antibodies (auto-Abs) in Patients with 

Age-Related Macular Degeneration (AMD). 

Nataliya I. Lenchik 1, 2 , F. Giorgianni 3 , S. Beranova- 

Giorgianni 3 , I. C. Gerling 1 , M. Z. Radic 4 , A. 

Iannaccone 2 . 1 Medicine/Endocrinology, Univ. 

Tennessee HSC, Memphis, TN; 2 Hamilton Eye 

Institute, Univ. Tennessee HSC, Memphis, TN; 

3 

Pharmaceutical Sciences, Univ. Tennessee HSC, 

Memphis, TN; 4 Microbiology, Immunology & 

Biochemistry, Univ. Tennessee HSC, Memphis, TN 

4104 — A0022 Early ocular lipid deposition 

in a mouse model of hyperlipidemia and 

atherosclerosis. Michaela K. Mathews, T. Albukh, 

K. E. Duncan. Ophthalmology, Univ of Maryland, 

Baltimore, Baltimore, MD 

4105 — A0023 The role of systemic infection 

and response to Ranibizumab therapy for Age 

Related Macular Degeneration (AMD). Charles 

O. Pierce 1, 2 , M. Nelson 2 , J. Scott 1 , H. L. Griffiths 1 , 

N. L. James 1 , H. A. Thomson 1 , A. J. Cree 1 , A. J. 

Lotery 1, 2 . 1 Clinical Neurosciences, University of 

Southampton, Southampton, United Kingdom; 

2 

University Hospital of Southampton, Southampton, 

United Kingdom *CR 


274

Wednesday – Posters – 4106 – 4129 

4106 — A0024 Immunohistochemical analysis 

of primate drusen reveals homologous protein 

expression between monkey and human. 

Trevor J. McGill 1 , L. Renner 2 , A. R. Weiss 2 , K. D. 

Rittenhouse 3 , J. Lee 2 , J. Fruebis 3 , M. Sperling 3 , M. 

Neuringer 2 . 1 Ophthalmology, Casey Eye Institute- 

OHSU, Portland, OR; 2 Neuroscience, Oregon 

National Primate Research Center, Beaverton, OR; 

3 

Ophthalmology External Research Unit, Pfizer, 

Cambridge, MA *CR 

4107 — A0025 A Pathway-based Genome-wide 

Analysis Yields Multi-locus AMD Associations in 

Genes Encoding JNK/MAPK Pathway Elements, 

Platelet Activation Triggers, and Targets of 

miR34 and HDAC1. John Paul P. SanGiovanni. 

Clinical Trials Branch, National Eye Institute/NIH, 

Bethesda, MD 

4108 — A0026 Minocycline protects retinal 

pigment epithelial cells from hypoxia. Joanna 

DaCosta. Cranfield Health, Cranfield University, 

Cranfield, United Kingdom 

4109 — A0027 Dominantly Inherited Early 

Onset Maculopathy in Japanese Macaques: 

Drusen Progression. Anda Cornea 1 , L. Renner 1 , 

S. Hurst 1 , T. J. McGill 2 , M. E. Pennesi 2 , K. D. 

Rittenhouse 3 , M. Sperling 3 , J. Fruebis 3 , M. 

Neuringer 1, 2 . 1 Oregon National Primate Research 

Center, Oregon Health & Science University, 

Beaverton, OR; 2 Casey Eye Institute, Oregon 

Health & Science University, Portland, OR; 

3 

Ophthalmology External Research Unit, Pfizer, 


4110 — A0028 Progression of Atrophic 

Macular Degeneration in Rhesus Monkeys 

Deficient in Lutein/Zeaxanthin and Omega-3 

Fatty Acids. Laurie Renner 1 , S. Hurst 1 , T. J. 

McGill 2 , A. R. Weiss 1 , T. Stout 2 , D. J. Wilson 2 , M. 

Neuringer 1, 2 . 1 Oregon National Primate Research 

Center, Oregon Health & Science University, 

Beaverton, OR; 2 Casey Eye Institute, Oregon Health 

& Science University, Portland, OR *CR 

4111 — A0029 Biocompatible injectable 

hydrogel to extend the release of intravitreal 

drugs. Thomas R. Friberg 1, 2 , B. M. Rauck 2 , C. 

A. Medina-Mendez 1 , Y. Wang 2 . 1 Ophthalmology/ 

UPMC Eye Center, Univ of Pittsburgh, Pittsburgh, 

PA; 2 Bioengineering, University of Pittsburgh, 

Pittsburgh, PA *CR 

4112 — A0030 Effect of Repeated Delivery 

of Neural Progenitors on Vision Preservation 

in RCS Rats. Bin Lu 1 , Y. Tsai 1 , G. Adamus 2 , S. 

Girman 1 , L. Shen 1 , D. M. Gamm 3 , C. W. Morgans 2 , 

B. Shelley 1 , C. Svendsen 1 , S. Wang 1 . 1 Regenerative 

Medicine Institute, Cedars Sinai Medical Center, 

Los Angeles, CA; 2 Casey Eye Institute, Oregon 


3 

Department of Ophthalmology, University of 

Wisconsin, Madison, WI *CR 

4113 — A0031 Comparison of intravitreally 

injected ranibizumab versus aflibercept in the 

retina and choroid of the primate eye. Sylvie 

Julien, U. Schraermeyer. Experimental Vitreoretinal 

Surgery, Centre for Ophthalmology, Tuebingen, 

Germany *CR 

4114 — A0032 Metabolomic profiles distinguish 

Age-related Macular Degeneration patients. 

Samantha Williamson 1 , Y. Park 3 , K. Uppal 3 , V. 

Tran 3 , J. McGrath 2 , A. Agarwal 1 , M. A. Pericak- 

Vance 4 , J. L. Haines 2 , D. P. Jones 3 , M. A. Brantley 1 . 

1 

Vanderbilt Eye Institute, Vanderbilt University, 

Nashville, TN; 2 Center for Human Genetics 

Research, Vanderbilt University, Nashville, TN; 

3 

Department of Medicine, Emory University, 

Atlanta, GA; 4 Hussman Institute of Human 

Genomics, Miller School of Medicine, University of 

Miami, Miami, FL *CR 

4115 — A0033 Metabolites that discriminate 

between neovascular AMD and control patients 

associate with different ARMS2 genotypes. 

Megan B. Parks 1 , Y. Park 2 , L. Burgess 1 , K. Lee 3 , 

P. Sternberg 1 , D. P. Jones 2 , M. A. Brantley 1 . 

1 


Nashville, TN; 2 Department of Medicine, Emory 

University, Atlanta, GA; 3 Department of Industrial 

Engineering, Hanyang University, Seoul, Republic 

of Korea 

4116 — A0034 The Composition of the 

Vitreous Proteome in Patients with Wet AMD 

Can Differentiate Between CNV and RAP: An 

Important New Diagnostic Tool. Stephanie M. 

Ecker, J. C. Hines, A. O. Igbre, B. M. Glaser. Ocular 

Proteomics, National Retina Institute, Towson, MD 

*CR 

4117 — A0035 Metabolic pathways associated 

with Age-related Macular Degeneration (AMD). 

L. Goodwin Burgess 1 , Y. Park 2 , M. B. Parks 1 , K. 

Lee 3 , P. Sternberg 1 , D. P. Jones 2 , M. A. Brantley 1 . 

1 


Nashville, TN; 2 Department of Medicine, Emory 

University, Atlanta, GA; 3 Department of Industrial 

Engineering, Hanyang University, Seoul, Republic 

of Korea 

4118 — A0036 Age-related macular 

degeneration and complement C3 in liver 

transplant patients. Samir Khandhadia 1, 2 , S. 

Hakobyan 3 , A. J. Cree 1 , A. J. Lotery 1, 2 . 1 Clinical and 

Experimental Sciences, Clinical Neurosciences, 

University of Southampton, Southampton, 

United Kingdom; 2 Eye Unit, University Hospital 

Southampton NHS Foundation Trust, Southampton, 

United Kingdom; 3 School of Medicine, Cardiff 

University, Cardiff, United Kingdom *CR 

4119 — A0037 Ophthalmologic exam in Age 

Macular Degeneration-Alzheimer Disease: 

its interest in detection, follow-up of AMD, of 

Alzheimer disease, its relevance to highlight 

the links and correlations between AMD and 

AD. Corinne Gonzalez. Ophthalmology, Cabinet 

Medical, Toulouse, France 

4120 — A0038 Variants in the VEGFA gene and 

visual outcome after anti-VEGF treatment for 

neovascular age-related macular degeneration. 

Manuel M. Hermann 1 , P. S. Muether 1 , D. 

Smailhodzic 2 , A. I. Den Hollander 2 , B. Kirchhof 1 , S. 

Fauser 1 . 1 Department of Ophthalmology, University 

Hospital of Cologne, Koeln, Germany; 2 Department 

of Ophthalmology, Radboud University Nijmegen 

Medical Center, Nijmegen, Netherlands *CR, f 

4121 — A0039 Level of vascular endothelial 

growth factor 165b in human aqueous humor. 

Takayuki Baba, G. Bikbova, M. Kitahashi, H. 

Yokouchi, M. Sakurai, M. Kubota-Taniai, S. 

Yamamoto. Ophthalmology & Visual Science, Chiba 

Univ Grad School of Med, Chiba, Japan 

4122 — A0040 Plasma levels of vascular 

endothelial growth factor and anti-vascular 

endothelial growth factor before and after 

intravitreal injection of anti-vascular endothelial 

growth factor. Sang Jun Park, M. Yoon, A. 

Chung, H. Chin. Department of Ophthalmology, 

Inha Vision Science Laboratory, Inha University 

School of Medicine, Incheon, Democratic People’s 


4123 — A0041 Quercetin Protects Hydrogen 

Peroxide Damaged Human Retinal Pigment 

Epithelial (hRPE) Cells and Inhibits Vascular 

Endothelial Growth Factor (VEGF) Production. 

Andrew Kumar 1, 2 , P. C. Kothary 2 , M. A. Del Monte 2 . 

1 

Wayne State University, Detroit, MI; 2 Department 

of Ophthalmology and Visual Science, University of 

Michigan, Ann Arbor, MI 

4124 — A0042 Lutein supplementation leads 

to a decreased level of circulating complement 

factors. Tos TJM Berendschot 1 , Y. Tian 1 , I. J. 

Murray 2 , M. Makridaki 2 , R. van der Veen 1 , A. 

Kijlstra 1 . 1 University Eye Clinic Maastricht, 

Maastricht, Netherlands; 2 Faculty of Life Sciences, 

University of Manchester, Manchester, United 

Kingdom f 

4125 — A0043 Hyperhomocysteinemia as a risk 

factor of polypoidal choroidal vasculopathy. Hui- 

Chen Cheng 1, 2 , P. Lin 1, 2 . 1 Ophthalmology, School of 

Medicine, National Yang-Ming University, Taipei, 

Taiwan; 2 Ophthalmology, Taipei Veterans General 

Hospital, Taipei, Taiwan 

4126 — A0044 Influence of bevacizumab 

on Platelet activation profile in vitro. Bianka 

Sobolewska 1 , F. Ziemssen, C. Grimmel 2 , J. 

Kwiatkowska 3 , M. S. Spitzer 1 , M. Gawaz 3 , 

T. Biedermann 2 , K. Stellos 3 . 1 Centre for 

Ophthalmology, University of Tuebingen, 

Tuebingen, Germany; 2 Dermatology, University of 

Tuebigen, Tuebingen, Germany; 3 Cardiology and 

Cardiovascular Medicine, University of Tuebigen, 

Tuebingen, Germany *CR 

4127 — A0045 Effects of Plasma Kallikrein on 

the neuroretina in diabetic rats. Gongxiong Wu, 

E. P. Feener. Vascular Cell Biology, Joslin Diabetes 

Center, Boston, MA *CR 

4128 — A0046 Choroidal Neovascularization 

Response of New Zealand White Rabbits and 

Dutch Belt Pigmented Animals to Sustained 

Simultaneous Release of both VEGF and bFGF 

within the Suprachoroidal Space. Corinne 

G. Wong. Ophthalmic Drug Dev, Sclera LLC, 

Carlsbad, CA 

4129 — A0047 Associations of IL-10 with 

Choroidal Neovascularization in high myopia. 

Yukimi Yamamoto 1 , D. Miyazaki 1 , S. Sasaki 2 , K. 

Miyake 1 , S. Kaneda 1 , Y. Ikeda 1 , A. Yamasaki 1 , Y. 

Inoue 1 . 1 Tottori University, Yonago, Japan; 2 Okihospital, 

Oki District, Japan 


8:30 am – 10:15 am 


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8:30 am – 10:15 am 



Retina 

414 AMD III, RE 

Moderators: Itay Chowers and Christine A. Curcio 

4130 — A0048 Focal Retinal Sensitivity Before 

and After Selective Retina Therapy for Central 

Serous Chorioretinopathy. Ayako Yasui 1 , M. 

Yamamoto 1 , T. Kohno 1 , T. yoneda 1 , Y. Yoshida 1 , 

H. Iwami 1 , D. Theisen-Kunde 2 , Y. Miura 2, 3 , R. 

Brinkmann 2 , K. Shiraki 1 . 1 Ophthalmology and 

Visual Science, Osaka city University, Osaka, 

Japan; 2 Medical Laser Center Luebeck, Luebeck, 

Germany; 3 Institute of Biomedical Optics, 

University of Luebeck, Luebeck, Germany *CR, f 

4131 — A0049 Automatic Temperature 

Controlled Retinal Photocoagulation Facilitates 

Four Predictable Lesion Strengths Including 

Sub-threshold Lesions. Stefan O. Koinzer 1 , 

C. Hesse 1 , A. Baade 2 , K. Schlott 3, 2 , A. Caliebe 4 , 

M. Saeger 1 , R. Brinkmann 3, 2 , J. Roider 1 . 

1 

Ophthalmology Campus Kiel, University hospital 

of Schleswig-Holstein, Kiel, Germany; 2 Medical 

Laser Center Luebeck GmbH, Luebeck, Germany; 

3 

Institute of Biomedical Optics, University of 

Luebeck, Luebeck, Germany; 4 Institute of Medical 

Informatics and Statistics, University hospital of 

Schleswig-Holstein, Kiel, Germany *CR 

4132 — A0050 Modulation of Transgene 

Expression in Retinal Gene Therapy by 

Selective Laser Treatment. Daniel Lavinsky 2, 1 , 

T. W. Chalberg 3 , Y. Mandel 2 , P. Huie 2 , R. Dalal 2 , 

M. F. Marmor 2 , D. V. Palanker 2 . 1 Ophthalmology, 

Federal Univesity of Rio Grande do Sul, Porto 

Alegre, Brazil; 2 Ophthalmology and HEPL, 

Stanford University, Stanford, CA; 3 Avalanche 

Biotechnologies, San Francisco, CA *CR 

4133 — A0051 Fluorescein angiography 

versus superimposed OCT-guided macular laser 

photocoagulation. Igor Kozak 1, 2 , S. El-Emam 1 , L. 

Cheng 1 , D. G. Bartsch 1 , J. Chhablani 3 , W. Freeman 1 , 

N. G. Ghazi 2 , J. Arevalo 2, 4 . 1 Ophthalmology, 

University of California San Diego, La Jolla, CA; 

2 

Vitreoretinal Division, King Khaled Eye Specialist 

Hospital, Riyadh, Saudi Arabia; 3 Vitreoretina, LV 

Prasad Eye Institute, Heyderabad, India; 4 Wilmer 

Eye Institute, Johns Hopkins University, Baltimore, 

MD *CR 

4134 — A0052 Six-month Report of 

Selective Retina Therapy on Central Serous 

Chorioretinopathy in Japanese Patients. Manabu 

Yamamoto 1 , T. Kohno 1 , T. Voneda 1 , Y. Yoshida 1 , H. 

Iwami 1 , A. Yasui 1 , D. Theisen-Kunde 2 , Y. Miura 3 , 

R. Brinkmann 3, 2 , K. Shiraki 1 . 1 Ophthalmology & 

Visual Sciences, Osaka City Univ Grad School 

of Medicine, Osaka-Shi, Japan; 2 Medical Laser 

Center Luebeck, Luebeck, Germany; 3 Institute 

of Biomedical Optics, University of Luebeck, 

Luebeck, Germany *CR, f 

4135 — A0053 Approach to Previously 

Vitrectomized Patients with Neovascular Age- 

Related Macular Degeneration with Reduced 

Response to Anti-vascular Endothelial Growth 

Factor Treatment. Mohammad Zubair Y. 

Arain 1 , Q. V. Hoang 1, 2 , J. S. Slakter 2 , S. Chang 1 . 

1 

Ophthalmology, Edward S. Harkness Eye Institute, 

Columbia University Medical Center, New York, 

NY; 2 Vitreous, Retina, Macula Consultants of New 

York, New York, NY *CR 

4136 — A0054 Selective retina treatment 

(SRT) automatically controlled by a real-time 

reflectometry in a rabbit model. Young Jung 

Roh 1 , E. Seifert 2 , T. Dirk 2 , Y. Park 1 , S. Kang 1 , R. 

Brinkmann 2 . 1 Ophthalmology, St Mary’s Hospital, 

Seoul, Republic of Korea; 2 Biomedical Optics, 

University of Lubeck, Lubeck, Germany *CR 

4137 — A0055 Effects of repeated subthreshold 

micropulse laser photocoagulation in rabbit 

eyes. Dongkyu Lee 1 , H. Kang 1 , S. Lee 2 , Y. You 1 , S. 

Kim 1 , O. Kwon 1 . 1 Retina center, Nune Eye Hospital, 

Seoul, Republic of Korea; 2 Ophthalmology, 

Soonchunhynag University Hospital, Seoul, 


4138 — A0056 Classification of Rabbit 

Photocoagulation Lesions in Optical Coherence 

Tomography and Class-related Coagulation 

Temperatures. Carola Hesse 1 , S. O. Koinzer 1 , A. 

Baade 2 , K. Schlott 2, 3 , A. Caliebe 4 , M. Saeger 1 , R. 

Brinkmann 3, 2 , J. Roider 1 . 1 Dept. of Ophthalmology, 

Campus Kiel, University Hospital of Schleswig- 

Holstein, Kiel, Germany; 2 Medical Lasercenter 

Lübeck GmbH, Lübeck, Germany; 3 Institut of 

Biomedical Optics, University of Lübeck, Lübeck, 

Germany; 4 Institut of Medical Informatics and 

Statistics, University Hospital of Schleswig- 

Holstein, Kiel, Germany *CR 

4139 — A0057 Various Laser Treatments for 

Retinal Capillary Hemangioma. Liqin Gao, F. 

Zhang. Department of Ophthalmology, Beijing 

Tongren Hospital, Beijing, China 

4140 — A0058 Subthreshold diode micropulse 

laser photocoagulation versus low-fluence 

photodynamic therapy for the treatment of 

chronic central serous chorioretinopathy. 

Juan Giralt 1 , R. P. Casaroli-Marano 1 , A. Burés- 

Jelstrup 2 , R. Navarro 2 , J. Martinez-Toldos 3 , C. 

Fernandez-Martinez 3 , M. Alforja 1 , A. Rey Torrente 1 . 

1 

Ophthalmology, Hospital Clinic de Barcelona, 

Barcelona, Spain; 2 IMO, Barcelona, Spain; 

3 

Hospital General Universitario de Elche, Elche, 

Spain *CR 

4141 — A0059 Early changes on SD-OCT 

in eyes with cystoid macular edema (CME) 

after 577 nm subthreshold MicroPulse Laser 

Treatment (MPLT). Paola Salvetti 1 , L. de Polo 1, 2 , 

M. Oldani 1, 2 , R. Ruello 1 . 1 Centro Oculistico 

Bergamasco, Bergamo, Italy; 2 Eye Clinic 

Department of Biomedical and Clinical Science 

“Luigi Sacco”, Luigi Sacco Hospital, Milano, Italy 

4142 — A0060 Threshold and Subthreshold 

Retinal Laser Therapy. But which Threshold? 

Giorgio Dorin. Clinical Application Development, 

IRIDEX Corp, Mountain View, CA *CR 

4143 — A0061 Persistence of Weekly Vision 

Self-monitoring Behavior in Non-Neovascular 

Age-Related Macular Degeneration Subjects 

Randomized to the Vision and Memory 

Stimulating (VMS) booklet. Mark C. Roser 1 , P. 

Beaton 1 , S. Torr-Brown 1 , A. Nwanko 2 , G. Dagnelie 2 , 

A. K. Bittner 2 . 1 Results Group, LLC, Hebron, CT; 

2 

1Johns Hopkins Wilmer Eye Institute, Baltimore, 

MD *CR, f 

4144 — A0062 Screening for AMD at an 

University Hospital: Database análisis and 

considerations. Carmen N. Demetrio, M. Zas. 

Ophthalmology, Hospital de Clínicas, Buenos Aires, 

Argentina 

4145 — A0063 Zinc supplementation lowers 

complement overactivation in patients with 

age-related macular degeneration. B. Jeroen 

Klevering 1 , D. Smailhodzic 1 , A. I. Den Hollander 1, 2 , 

J. P. van de Ven 1 , J. M. Groenewoud 3 , S. Fauser 4 , 

M. R. Daha 5 , G. van der Wilt 3 , C. B. Hoyng 1 . 

1 

Ophthalmology, Radboud University Nijmegen 

Medical Centre, Nijmegen, Netherlands; 

2 

Department of Human Genetics, Radboud 

University Nijmegen Medical Centre, Nijmegen, 

Netherlands; 3 Department of Epidemiology, 

Biostatistics, and HTA, Radboud University 

Nijmegen Medical Centre, Nijmegen, Netherlands; 

4 

Ophthalmology, University of Cologne, Cologne, 

Germany; 5 Department of Nephrology, Leiden 

University Medical Center, Leiden, Netherlands f 

4146 — A0064 Novel Laser treatment for 

Early Age-related Macular Degeneration. Kate 

Brassington 1 , L. Gurrin 3 , K. Aung 1 , R. H. Guymer 1, 2 . 

1 

Centre for Eye Research Australia, Royal Victorian 

Eye and Ear Hospital, Melbourne, VIC, Australia; 

2 


Melbourne, Melbourne, VIC, Australia; 3 Melbourne 

School of Population Health, University of 

Melbourne, Melbourne, VIC, Australia *CR, f 

4147 — A0065 ex vivo Spectral Domain 

Optical Coherence Tomography (SD-OCT) 

of Retina-Choriocapillaris (R-CC) Specimen: 

Factors influencing Image Quality. Laurenz L. 

Sonnentag, S. Grisanti, M. Rudolf. Department of 

Ophthalmology, University of Luebeck, Luebeck, 

Germany *CR 

4148 — A0066 Quantitative Optical Coherence 

Tomography Analysis Of Change in Pigment 

Epithelial Detachment Morphology Following 

Intravitreal Aflibercept Injection In Eyes With 

Recalcitrant Neovascular Age-Related Macular 

Degeneration. Mihai Mititelu, D. S. Grewal, 

D. Sarezky, R. Mirza, M. K. Gill, A. T. Lyon. 

Ophthalmology, Northwestern University, Feinberg 

School of Medicine, Chicago, IL 

4149 — A0067 Drusen Detection on 

Multimodal Imaging- Early Markers 

Observational Study. Rufino Silva 1, 2 , R. E. Hogg 3 , 

G. Murphy 3 , G. Staurenghi 4 , C. Rosina 4 , A. Santos 2 , 

U. Chakravarthy 3 . 1 Ophthalmology, Universitary 

Hospital Coimbra Center, Coimbra, Portugal; 2 CEC, 

AIBILI, Coimbra, Portugal; 3 Center for Vision 

and Vascular Science, Queen’s University Belfast, 

Belfast, Ireland; 4 Dept of Biomedical and Clinical 

Science (Luigi Sacco), University of Milan, Milan, 

Italy *CR 


276


4150 — A0068 Automated prediction of AMD 

progression from quantified SD-OCT images. 

Theodore Leng 1 , L. de Sisternes 2 , Q. Chen 2, 3 , J. Ma 1 , 

V. Mahendra 1 , D. Rubin 2 . 1 Ophthalmology, Byers 

Eye Institute at Stanford, Palo Alto, CA; 2 Radiology 

and Medicine (Biomedical Informatics Research), 

Stanford University School of Medicine, Stanford, 

CA; 3 School of Computer Science and Engineering, 

Nanjing University of Science and Technology, 

Nanjing, China *CR 

4157 — A0075 The Dynamics of 

Hyperreflectant Central Target Lesions 

In Reticular Macular Disease (RMD) In 

Age-related Macular Degeneration (AMD). 

Nicole M. Pumariega 1 , R. M. Cymerman 1 , B. 

Butler 1 , N. Massamba 2 , E. H. Souied 2 , R. Smith 1 . 

1 

Ophthalmology, New York University Medical 

Center, College of Medicine, New York, NY; 

2 

Retina Creteil, Creteil Eye Clinic Univ Hospital, 

Créteil, France *CR 

4163 — A0081 Dark Adaptometry As a 

Functional Outcome Measure in Age-Related 

Macular Degeneration. E Lauren Doss 1, 2 , T. 

Glaser 1, 2 , E. Agrón 2 , D. L. Nigam 2 , W. T. Wong 3 , 

E. Y. Chew 2 , C. A. Cukras 2 . 1 School of Medicine, 

University of California-San Francisco, San 

Francisco, CA; 2 National Eye Insititute, National 

Institutes of Health (NIH), Bethesda, MD; 3 Office 

of the Scientific Director, National Eye Institute, 

National Institutes of Health (NIH), Bethesda, MD 

4164 — A0082 Diagnostic accuracy of 

multifocal pupillographic objective perimetry in 

early age-related macular degeneration. Faran 

Sabeti 1, 2 , A. Saikal 1, 2 , M. Kolic 1, 2 , C. F. Carle 1, 2 , 

R. W. Essex 3 , A. C. James 1, 2 , T. Maddess 1, 2 . 1 Eccles 

Institute of Neuroscience, Australian National 

University, Canberra, ACT, Australia; 2 ARC 

Centre of Excellence in Vision Science, Canberra, 

ACT, Australia; 3 Ophthalmology Department, The 

Canberra Hospital, Canberra, ACT, Australia *CR 

4151 — A0069 Significance of Drusen 

Regression in Intermediate Age-Related Macular 

Degeneration (AMD) in Progression to Advanced 

Disease. Tanya Glaser 1, 2 , E. Doss 1, 2 , E. Agrón 1 , 

D. L. Nigam 1 , E. Y. Chew 1 , W. T. Wong 3 . 1 National 

Eye Institute, National Institutes of Health (NIH), 

Bethesda, MD; 2 School of Medicine, University 

of California - San Francisco, San Francisco, CA; 

3 

Office of the Scientific Director, National Eye 

Institute, National Institutes of Health (NIH), 

Bethesda, MD 

4152 — A0070 The evaluation of fundus autofluorescence 

( FAF) patterns in patient’s with 

Geographic Atrophy( GA) and the correlation 

with visual acuity. Ina K. Jaurre, S. Mudhar, 

N. Jain, M. Polyzos, G. Menon, L. North, M. 

N. Chandran. Eye treatment unit, Frimley Park 

Hospital, Frimley, Surrey, United Kingdom *CR 

4153 — A0071 Investigation into the ability 

of Preferential Hyperacuity Perimetry (PHP) 

to detect reactivation of neovascularisation in 

patients undergoing ranibizumab injections 

for age-related macular degeneration (AMD). 

Stephanie Mroczkowska 1 , A. Calcagni 3, 1 , J. 

M. Gibson 1 , U. Chakravarthy 2 , R. E. Hogg 2 . 

1 

Ophthalmic Research Group, Aston University, 

Birmingham, United Kingdom; 2 Centre for Vision 

and Vascular Science, Queen’s University Belfast, 

Belfast, Ireland; 3 Birmingham and Midland Eye 

Centre, Birmingham, United Kingdom *CR 

4154 — A0072 Automated Drusen 

Segmentation and Quantification from SD- 

OCT Images to Predict AMD Progression. 

Luis de Sisternes 1 , T. Leng 2 , Q. Chen 3 , J. Ma 2 , V. 

Mahendra 2 , D. Rubin 1 . 1 Radiology and Medicine, 

Stanford University School of Medicine, Stanford, 

CA; 2 Ophthalmology, Byers Eye Institute at 

Stanford, Palo Alto, CA; 3 School of Computer 

Science and Engineering, Nanjing University of 

Science and Technology, Nanjing, China *CR 

4155 — A0073 Factors that predict the 

incidence of fellow eye in age-related macular 

degeneration. Kyung Min Koh, Y. Lew, M. Choi, S. 

Yoo, S. Cho, D. Lee, T. Lee, C. Kim, J. Han. Kim’s 

Eye Hospital, Seoul, Republic of Korea 

4156 — A0074 Development of Choroidal 

Neovascularization in the Second Eye of 

Neovascular AMD Patients Treated with Anti- 

VEGF Drugs. Jonah Abraham, M. J. Elman. Elman 

Retina Group, PA, Baltimore, MD *CR 

4158 — A0076 Relationship between 

reflectivity and volume of subretinal tissue in 

choroidal neovascular membranes associated 

with age-related macular degeneration. Wissam 

Charafeddin, S. Sadda, M. Nittala, M. S. Humayun, 

A. A. Oregon-Miranda. Doheny eye institute, Los 

angeles, CA *CR 

4159 — A0077 Rod and Cone function and 

its relationship to OCT sub structural changes 

in Age-related Macular degeneration. Brighu 

Swamy 1 , E. N. Wong 3 , S. Degli Esposti 1 , P. A. 

Keane 2, 1 , M. D. Crossland 1 , D. A. Sim 1 , A. Tufail 1, 2 , 

F. K. Chen 3 . 1 Medical Retina, Moorfields Eye 

Hospital, London, United Kingdom; 2 UCL Institute 

of Ophthalmology National Institute for Health 

Research Biomedical Research Centre, London, 

United Kingdom; 3 Lions Eye Institute, Perth, WA, 

Australia *CR 

4160 — A0078 OPERA (Optos Peripheral 

Retina AMD) Study Croatia: Reticular 

pigmentation in AMD vs. controls. Vesna Jurisic 

Friberg 1, 3 , B. Andrijevic Derk 2 , T. Knezevic 2 , 

M. Zoric-Geber 2 , G. Bencic 2 , Z. Vatavuk 2 , T. 

R. Friberg 4, 2 . 1 University Eye Clinic, Clinical 

Center, University of Sarajevo, Sarajevo, Bosnia 

and Herzegovina; 2 Ophthalmology, Kbc Sestre 

Milosrdnice and the University of Zagreb, Zagreb 

Croatia, Zagreb, Croatia; 3 Ophthalmology, 

Children’s Hospital-UPMC, Pittsburgh, PA; 

4 

Ophthalmology, UPMC Eye Center, University of 

Pittsburgh, Pittsburgh, PA *CR 

4161 — A0079 Morphological characteristics 

associated with drusen progression on Spectral 

Domain OCT (SD-OCT). Jeong W. Pak 1 , A. 

Domalpally 1 , D. Myers 1 , X. Yang 2 , A. R. Narkar 1 , Y. 

Huang 1 , R. P. Danis 1 . 1 Ophthalmology and Visual 

Science, University of Wisconsin - Madison, 

Madison, WI; 2 Beijing Tongren Eye Center, Capital 

Medical University, Beijing, China *CR 

4162 — A0080 Clinical Outcomes of Eyes 

with Neovascular Lesions Composed of >50% 

Blood Treated with Anti-VEGF Therapy in the 

Comparison of AMD Treatments Trials (CATT). 

Michael M. Altaweel 1 , J. E. Grunwald 2 , E. Daniel 2 , 

G. Ying 2 , J. Huang 2 , G. J. Jaffe 3 . 1 Ophthalmology 

& Visual Science, Univ of Wisconsin-Madison, 

Madison, WI; 2 Department of Ophthalmology, 

University of Pennsylvania, Philadelphia, PA; 

3 

Ophthalmology, Duke University, Durham, NC 

*CR, f 

4165 — A0083 Imaging of Focal 

Hyperpigmentary Changes in Intermediate Agerelated 

Macular Degeneration - A Longitudinal 

Analysis. Arno P. Goebel, S. Grundei, M. 

Fleckenstein, F. G. Holz, S. Schmitz-Valckenberg. 

Department of Ophthalmology, University of Bonn, 

Bonn, Germany *CR 

4166 — A0084 Reduction of the OCT second 

hyper-reflective band intensity is associated with 

a decreased in retinal function in eyes with agerelated 

macular degeneration. Chi D. Luu 1, 2 , Z. 

Wu 1, 2 , L. N. Ayton 1, 2 , R. H. Guymer 1, 2 . 1 Macular 

Research Unit, Centre for Eye Research Australia, 

East Melbourne, VIC, Australia; 2 Department of 

Ophthalmology, University of Melbourne, Parkville, 

VIC, Australia *CR 

4167 — A0085 Progression of Reticular 

Macular Disease (RMD) in Age-Related Macular 

Degeneration (AMD). Rachel M. Cymerman 1 , N. 

M. Pumariega 1 , A. G. Sperber 1 , N. Massamba 2 , 

E. H. Souied 2 , R. Smith 1 . 1 New York University 

Medical Center, School of Medicine, New York, 

NY; 2 L’Hôpital Intercommunal de Créteil, Créteil, 

France *CR 

4168 — A0086 Imaging of reticular drusen 

by multi-spectral confocal scanning laser 

ophthalmoscopy imaging. Jasmin Anke Ilka Auge, 

J. S. Steinberg, M. Fleckenstein, F. G. Holz, S. 

Schmitz-Valckenberg. University of Bonn, Bonn, 

Germany *CR 

4169 — A0087 Reticular Pseudodrusen in 

Early Age-Related Macular Degeneration is 

Associated with Choroidal Thinning. Aakriti 

Garg 1 , M. Oll 1 , S. Yzer 1 , R. Allikmets 1, 2 , S. Chang 1 , 

G. R. Barile 3 , R. Smith 4 , J. C. Merriam 1 , S. H. 

Tsang 1, 2 , S. Bearelly 1 . 1 Ophthalmology, Columbia 

University College of Physicians and Surgeons, 

New York, NY; 2 Pathology & Cell Biology, 

Columbia University College of Physicians and 

Surgeons, New York, NY; 3 Ophthalmology, 

Manhattan Eye, Ear, & Throat Hospital, New York, 

NY; 4 Ophthalmology, New York University Medical 

Center, New York, NY *CR 


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4170 — A0088 Reticular pseudodrusen and 

their topographic relation to choroidal watershed 

zones and localized changes in choroidal volume 

and choroidal thickness. Florian Alten, C. R. 

Clemens, N. Eter. University Eye Hosp Muenster, 

Muenster, Germany *CR 

4171 — A0089 Long-term evaluation of 

drusen area and volume using polarizationsensitive 

OCT. Ferdinand G. Schlanitz 1 , B. 

Baumann 2 , M. Bolz 1 , E. Gotzinger 2 , M. Pircher 2 , 

C. K. Hitzenberger 2 , U. Schmidt-Erfurth 1 . 

1 

Ophthalmology, Medical University of Vienna, 

Vienna, Austria; 2 Center for Medical Physics and 

Biomedical Engineering, Medical University of 

Vienna, Vienna, Austria *CR 

4172 — A0090 Longitudinal analysis of 

reticular drusen associated with age-related 

macular degeneration. Julia S. Steinberg, J. 

Auge, M. Fleckenstein, F. G. Holz, S. Schmitz- 

Valckenberg. Department of Ophthalmology, 

University of Bonn, Bonn, Germany *CR 

4173 — A0091 Preferential Hyperacuity 

Perimetry Monitoring in Patients During 

Treatment of Neovascular Age-related Macular 

Degeneration. Merina Thomas 1, 2 , Y. Wolfson 1 , V. 

Chaikitmongkol 1, 3 , N. M. Bressler 1 . 1 Department 

of Ophthalmology, Retina Division, Wilmer 

Eye Institute, Johns Hopkins University School 

of Medicine, Baltimore, MD; 2 Department of 

Ophthalmology, University of Illinois at Chicago, 

Chicago, IL; 3 Department of Ophthalmology, 

Chiang Mai University, Chiang Mai, Thailand *CR 

4174 — A0092 Visual outcomes of an Inject 

and Extend protocol of intravitreal antivascular 

endothelial growth factor treatment in 

neovascular age-related macular degeneration 

over two years. Farshad Abedi, S. Wickramsinghe, 

A. Islam, K. M. Inglis, R. H. Guymer. 

Ophthalmology, Centre for Eye Research Australia, 

University of Melbourne, Royal Victorian Eye and 

Ear Hospital, East Melbourne, VIC, Australia *CR 

4175 — A0093 Prospective Randomized 

Controlled Trial of Combination Ranibizumab 

and Ketorolac for Wet Age-Related Macular 

Degeneration. Andrea Russo 1 , C. Costagliola 2 , L. 

Delcassi 1 , M. R. Romano 3 , F. Semeraro 1 . 1 Univ degli 

Studi di Brescia - Italy, Brescia, Italy; 2 Università 

del Molise, Campobasso, Italy; 3 Istituto Clinico 

Humanitas, Milano, Italy *CR 

4176 — A0094 Aflibercept Rescue of 

Bevacizumab- or Ranibizumab-Resistant 

Choroidal Neovascularization in Age-Related 

Macular Degeneration. Cheryl A. Arcinue, F. Ma, 

G. Barteselli, S. Lee, S. El-Emam, A. L. Doede, M. 

Gomez, W. Freeman. Jacobs Retina Center, UCSD 

Shiley Eye Center, La Jolla, CA *CR 

Exhibit Hall B0170-B0195 



415 Retinal and Photoreceptor 

Degeneration II: Cell Biology 

Moderators: Susan E. Brockerhoff and 

Ulrich F. Luhmann 

4177 — B0170 Myo/Nog Cells Promote 

Photoreceptor Cell Survival in the Stressed 

Retina. Arturo Bravo-Nuevo 1 , A. Brandli 2 , J. V. 

Gerhart 1 , M. Pitts 1 , J. Stone 2 , M. George-Weinstein 1 . 

1 

Lankenau Institute for Medical Research, 

Wynnewood, PA; 2 Physiology, University of 

Sydney, Sydney, NSW, Australia *CR 

4178 — B0171 Responsiveness of rhodopsin 

kinase GRK1 promoter activity to light. Shahrokh 

C. Khani, Z. Oskouie. Ophthalmology, Schepens 

Eye Research Inst, Boston, MA 

4179 — B0172 Early indications of pending 

degeneration in a mouse model of photoreceptor 

light damage. Emily Levine 1 , R. J. Zawadzki 2 , H. 

Cheng 3 , S. I. Simon 4 , E. N. Pugh 1, 5 , M. E. Burns 1, 2 . 

1 

Cell Biology and Human Anatomy, UC Davis, 

Davis, CA; 2 Ophthalmology & Vision Science, 

UC Davis, Davis, CA; 3 Neurobiology, Physiology 

and Behavior, UC Davis, Davis, CA; 4 Biomedical 

Engineering, UC Davis, Davis, CA; 5 Physiology 

and Membrane Biology, UC Davis, Davis, CA 

4180 — B0173 Constitutive Rhodopsin 

Activation rather than Mistrafficking Results in 

Photoreceptor Death in the D190N Preclinical 

Model of Retinitis Pigmentosa. Javier Sancho- 

Pelluz 1, 2 , W. Lee 1 , Y. Tsai 1 , I. Washington 1 , S. H. 

Tsang 1, 4 , C. Lin 3, 4 . 1 Department of Ophthalmology, 

Columbia University, New York, NY; 2 Department 

of Medicine, Catholic University of Valencia, 

Valencia, Spain; 3 Herbert Irving Comprehensive 

Cancer Center, Columbia University, New York, 

NY; 4 Department of Pathology and Cell Biology, 

College of Physicians and Surgeons, Columbia 

University, New York, NY 

4181 — B0174 Insufficient proteasomal activity 

is a common stress factor in multiple forms 

of inherited retinal degeneration. Ekaterina 

Lobanova, S. Finkelstein, N. P. Skiba, V. Y. 

Arshavsky. Albert Eye Research Institute, Durham, 

NC 

4182 — B0175 Decreased Proteasomal Activity 

Causes Retinal Degeneration in Mice. Ryo 

Ando 1, 2 , K. Noda 1, 2 , U. Tomaru 3 , M. Kamoshita 4 , 

Y. Ozawa 4 , S. Notomi 5 , T. Hisatomi 5 , A. Kanda 1, 2 , 

S. Ishida 1, 2 . 1 Laboratory of Ocular Cell Biology 

and Visual Science, Hokkaido University Graduate 

School of Medicine, Sapporo, Japan; 2 Department 

of Ophthalmology, Hokkaido University 

Graduate School of Medicine, Sapporo, Japan; 

3 

Department of Pathology, Hokkaido University 

Graduate School of Medicine, Sapporo, Japan; 

4 

Department of Ophthalmology, Keio University 

School of Medicine, Tokyo, Japan; 5 Department 

of Ophthalmology, Graduate School of Medical 

Sciences, Kyushu University, Fukuoka, Japan *CR 

4183 — B0176 Rod Photoreceptor neuritic 

sprouting is responsive to Sema3A. Frank 

Kung 1, 2 , A. Axelrod 3 , D. R. Siegel 3 , E. Townes- 

Anderson 1 . 1 Biomedical Engineering, UMDNJ, 

Newark, NJ; 2 Biomedical Engineering, NJIT, 

Newark, NJ; 3 Department of Chemistry and 

Biochemistry, The University of Texas at Austin, 

Chesapeake, VA 

4184 — B0177 Strain Dependence of Myeloid 

Cell-Associated Retinal Dysplasia in Crb1 rd8 

Mice. Mark P. Krebs, W. Hicks, L. Stone, J. 

Naggert, P. M. Nishina. The Jackson Laboratory, 

Bar Harbor, ME 

4185 — B0178 The genetic background 

determines the severity of retinal pathology 

in homozygous Crb1 rd8/rd8 mice. Ulrich F. 

Luhmann 1 , L. S. Carvalho 1 , J. Cowing 1 , P. M. 

Munro 4 , P. Potter 3 , J. W. Bainbridge 1, 2 , R. R. 

Ali 1, 2 . 1 Department of Genetics, UCL Institute 

of Ophthalmology, London, United Kingdom; 

2 

NIHR Moorfields Biomedical Research Centre at 

Moorfields Eye Hospital NHS Foundation Trust 

and UCL Institute of Ophthalmology, London, 

United Kingdom; 3 MRC Harwell, Oxfordshire, 

United Kingdom; 4 Imaging Unit, UCL Institute of 

Ophthalmology, London, United Kingdom *CR 

4186 — B0179 Characterization of a Novel 

Mouse Mutant with Retinal Degeneration and 

Male Infertility. Chun-hong Xia 1 , B. Chang 2 , 

X. Gong 1 . 1 School of Optometry, University of 

California, Berkeley, Berkeley, CA; 2 The Jackson 

Laboratory, Bar Harbor, ME 

4187 — B0180 Electroretinographic and 

OCT Retinal Morphologic Characterization 

of the Crx Rdy Cat: An Animal Model for Severe 

Dominant Retinopathies Associated with CRX 

Mutations. Laurence M. Occelli 1 , J. T. Bartoe 1 , 

J. R. Querubin 1 , K. Narfstrom 2 , S. M. Petersen- 

Jones 1 . 1 Small Animal Clinical Sciences, Michigan 

State University, East Lansing, MI; 2 Dept of Vet 

Med & Surgery, University of Missouri-Columbia, 

Columbia, MO 

4188 — B0181 Comparative analysis of 

neurodegenerative markers in ten different 

animal models for retinal degeneration 

reveals prevalence of non-apoptotic cell death 

mechanisms. Blanca Arango-Gonzalez 1 , D. 

Trifunović 1 , A. Sahaboglu-Tekgöz 1 , K. Kranz 2 , 

S. Michalakis 3 , P. Farinelli 1, 4 , S. Cottet 5 , P. 

A. Ekstrom 4 , M. Ueffing 1 , F. Paquet-Durand 1 . 

1 

Institute for Ophthalmic Research, Centre for 

Ophthalmology, Eberhard Karls-Universität 

Tübingen, Tuebingen, Germany; 2 Department of 

Neurobiology, University of Oldenburg, Oldenburg, 

Germany; 3 Center for Integrated Protein Science 

Munich (CIPSM) and Department of Pharmacy, 

Center for Drug Research, Ludwig-Maximilians- 

Universität München, Munich, Germany; 4 Division 

of Ophthalmology, Department of Clinical Sciences, 

University of Lund, Lund, Sweden; 5 Institute 

for Research in Ophthalmology, University of 

Lausanne, Lausanne, Switzerland 


278


4189 — B0182 Mechanism of cGMP-induced 

Retinal Degeneration. Tian Wang 1 , J. Chen 1 , S. H. 

Tsang 2 . 1 Zilkha Neurogenetic Institute, Keck School 

of Medicine, University of Southern California, Los 

Angeles, CA; 2 Bernard & Shirlee Brown Glaucoma 

Laboratory, Edward S. Harkness Eye Institute, and 

Department of Pathology & Cell Biology, Columbia 

University, New york, NY 

4190 — B0183 Genetic deletion of S-opsin 

prevents rapid cone degeneration in a mouse 

model of Leber congenital amaurosis. Tao 

Zhang 1, 2 , A. Jones 1, 2 , S. Wang 1, 2 , E. N. Pugh 3 , W. 

Baehr 1, 2 , Y. Fu 1, 2 . 1 Dept of Ophthalmology and 

Visual Sciences, University of Utah, Salt Lake City, 

UT; 2 Neurobiology & Anatomy, University of Utah, 

Salt Lake City, UT; 3 Departments of Physiology 

and Cell Biology, University of California, Davis, 

CA *CR 

4191 — B0184 Gene Expression Alterations 

in Mouse Retina with Deficiency of Cone Cyclic 

Nucleotide-gated Channel Subunits CNGA3 and 

CNGB3. Hongwei Ma 1 , A. Thapa 1 , L. M. Morris 1 , 

S. Michalakis 2 , M. Biel 2 , M. B. Frank 3 , M. Bebak 3 , 

X. Ding 1 . 1 The Department of Cell Biology, Univ 

of Oklahoma Health Sci Ctr, Oklahoma City, OK; 

2 

The Center for Integrated Protein Science Munich 

(CIPSM) and Department of Pharmacy - Center for 

Drug Research, Ludwig-Maximilians-Universität 

München, Munich, Germany; 3 The Arthritis and 

Clinical Immunology Program, Oklahoma Medical 

Research Foundation, Oklahoma City, OK 

4192 — B0185 Inhibition of S1P degradation 

rescues 661W cells from oxidative stress. Carlotta 

Fabiani, P. Signorelli, A. Caretti, R. Ghidoni. 

Department of Health Sciences, University of 

Milan, Milan, Italy 

4193 — B0186 Calcium fluxes in degenerating 

pde6c w59 mutant zebrafish cones indicate a 

non-apoptotic mechanism of cell death. Susan 

E. Brockerhoff, E. Y. Ma, A. Lewis, G. Stearns. 

Biochemistry, University of Washington, Seattle, 

WA 

4194 — B0187 Molecular mechanisms that 

contribute to vision loss in T17M RHO mice. 

Sonali R. Nashine 1 , Y. Bhootada 2 , A. S. Lewin 3 , 

M. S. Gorbatyuk 1, 2 . 1 Cell Biology and Anatomy, 

Univ of North Texas Hlth Sci Ctr, Fort Worth, 

TX; 2 University of Alabama, Birmingham, AL; 

3 

University of Florida, Gainsville, FL *CR 

4197 — B0190 Interaction of Tubby-like 

protein-1 (Tulp1) and Microtubule-Associated 

Proteins (MAPs) in the Mouse Retina. Lindsey 

A. Ebke 1 , G. H. Grossman 1 , C. D. Beight 1 , G. J. 

Pauer 1 , S. A. Hagstrom 1, 2 . 1 Cole Eye Institute, 

Cleveland Clinic, Cleveland, OH; 2 Department of 

Ophthalmology, Cleveland Clinic Lerner College 

of Medicine of Case Western Reserve University, 

Cleveland, OH 

4198 — B0191 The Protective effects 

of Resveratrol in Experimental Retinal 

Detachment. Wei Huang, G. Li, J. Qiu, P. 

Gonzalez, P. Challa. Ophthalmology, Duke Eye 

Center, Durham, NC 

4199 — B0192 LED light source induced 

retinal photoreceptor hazard in a rat model. 

Yu-Man Shang 1, 2 , C. Yang 2, 3 , G. Wang 1, 4 , L. Lin 1, 2 . 

1 

Institute of Environmental Health, National 

Taiwan University, Taipei, Taiwan; 2 Department 

of Ophthalmology, National Taiwan University 

Hospital, Taipei, Taiwan; 3 College of Medicine, 

National Taiwan University, Taipei, Taiwan; 

4 

Department of Public Health, National Taiwan 

University, Taipei, Taiwan 

4200 — B0193 Neuroprotective effects of 

norgestrel in retinitis pigmentosa: preservation 

of retinal cytoarchitecture and synaptic 

connectivity. Violeta Gomez-Vicente 1 , L. 

Fernandez-Sanchez 1 , G. Groeger 2 , F. Doonan 2 , T. 

G. Cotter 2 , N. Cuenca 1 . 1 Physiology, Genetics & 

Microbiology, University of Alicante, Alicante, 

Spain; 2 Biochemistry, BioSciences Institute, 

University College Cork, Cork, Ireland *CR 

4201 — B0194 Manipulating MSC Homing 

To Enhance Its Efficacy in Preserving Vision. 

Shaomei Wang 1 , Y. Tsai 1 , S. Girman 1 , L. Shen 1 , 

C. W. Morgans 2 , G. Adamus 3 , W. Xiong 1 , V. 

Arumugaswami 1 , C. Svendsen 1 , B. Lu 1 . 1 Biomedical 

Science, Regenerative Medicine Institute, Los 

Angeles, CA; 2 Physiology & Pharmacology, 

OHSU, Portland, OR; 3 Casey Eye Institute, OHSU, 

Portland, OR 

4202 — B0195 NecroX-5 Rescue Retinal 

Degeneration Induced by N-methyl-Nnitrosourea 

in Rats. Sun-Sook Paik, J. Jeon, I. 

Kim. Anatomy, College of Medicine, The Catholic 

University of Korea, Seoul, Republic of Korea 



Anatomy/Pathology / Physiology/Pharmacology 

416 Uveal Melanoma 

Moderators: Tatyana Milman and Rebecca Stacy 

4203 — B0196 Comparison of Two Melanoma 

Cell Lines as Mouse-Models of Uveal Melanoma. 

Marta M. Kilian 1 , K. U. Loeffler 1 , H. E. 

Grossniklaus 2 , F. G. Holz 1 , C. Pfarrer 3 , C. Kurts 4 , 

M. C. Herwig 1 . 1 Department of Ophthalmology, 

University of Bonn, Bonn, Germany; 2 Department 

of Ophthalmology, Emory University, Atlanta, GA; 

3 

Department of Anatomy, University of Veterinary 

Medicine Hannover, Hannover, Germany; 

4 

Institutes of Molecular Medicine and Experimental 

Immunology, University of Bonn, Bonn, Germany 

*CR 

4204 — B0197 Calcium regulation by transient 

receptor potential channels in human uveal 

melanoma cells. Stefan Mergler 1 , A. Boehm 1 , R. 

Derckx 1 , L. Schmelzer 1 , F. Garreis 2 , A. Riechardt 1 . 

1 

Department of Ophthalmology, University 

Medicine Charite Berlin, Berlin, Germany; 

2 

Department of Anatomy II, University Erlangen- 

Nuremberg, Erlangen, Germany 

4205 — B0198 Unusual sodium-potassium 

dynamics and Na,K-ATPase expression in Mel- 

290 uveal melanoma cells. Elena B. Rodriguez de 

Turco, N. A. Delamere, M. Shahidullah. Physiology, 

University of Arizona, Tucson, AZ 

4206 — B0199 Host Pigment Epithelium- 

Derived Factor (PEDF) Prevents Progression 

of Uveal Melanoma Metastasis in the Liver 

and Inhibits Formation of Blood Vessels in the 

Metastatic Microenvironment. John M. Lattier 1 , 

H. Yang 1 , S. Crawford 2 , H. E. Grossniklaus 1 . 1 Dept. 

of Ophthalmology, Emory University, Atlanta, GA; 

2 

Dept. of Pathology, University of St. Louis, St. 

Louis, MO 

4207 — B0200 Pre-clinical analysis of 

Crizotinib in MAPK independent uveal 

melanoma metastases. Pieter van der Velden, M. 

de Lange, M. Versluis, G. P. Luyten, M. M. Jager. 

Ophthalmology, LUMC, Leiden, Netherlands 

4208 — B0201 Vemurafenib as a therapeutic 

option for treatment of melanoma. Simon F. 

Leicht, C. M. Wertheimer, R. Liegl, A. Kampik, 

K. Eibl-Lindner. Department of Ophthalmology, 

Ludwig-Maximilians-University, Munich, Germany 

*CR 


8:30 am – 10:15 am 

4195 — B0188 Extracellular ATP accelerates 

photoreceptor cell death via ligation of P2X7 

receptor in retinal detachment. Shoji Notomi, 

T. Hisatomi, Y. Murakami, A. Takeda, Y. Ikeda, 

H. Enaida, T. Ishibashi. Ophthalmology, Kyushu 

University, Fukuoka, Japan *CR 

4196 — B0189 Identification and 

characterization of Tubby C-terminal binding 

proteins by ORF phage display. Nora B. 

Caberoy 1 , G. S. Alvarado 2 , J. N. Nocillado 1 . 1 School 

of Life Sciences, University of Nevada Las Vegas, 

Las Vegas, NV; 2 Ophthalmology, Bascom Palmer 

Eye Institute, University of Miami Miller School of 

Medicinel, Miami, FL 

4209 — B0202 5-Azacytidine Reduces 

Growth, Invasiveness, and Clonogenicity of 

Uveal Melanoma Cells and Decreases the Rate 

of Metastasis. Fatemeh Rajaii, L. Asnaghi, S. 

L. Merbs, J. T. Handa, C. Eberhart. Department 

of Ophthalmology, Wilmer Eye Institute, Johns 

Hopkins University, Baltimore, MD *CR 


279



8:30 am – 10:15 am 

4210 — B0203 Cytotoxic Effects of the 

Combination of Resveratrol and N-acetylcysteine 

on Cultured Human Uveal Melanoma Cells. 

Tommaso Vagaggini 1, 2 , D. Hu 2 , A. Sclafani 2 , S. A. 

McCormick 2 , J. E. Roberts 1 . 1 Natural Sciences, 

Fordham University, New York, NY; 2 Pathology, 

New York Eye and Ear Infirmary, New York, NY 

*CR 

4211 — B0204 Simultaneous Inhibition of 

the HGF/MET and Erk1/2 Pathways Affect 

Uveal Melanoma Cell Growth and Migration. 

Chandrani Chattopadhyay, E. A. Grimm, S. E. 

Woodman. Melanoma Medical Oncology, UT MD 

Anderson Cancer Ctr, Houston, TX *CR 

4212 — B0205 Cyclooxygenase-2 (COX-2) 

expression in primary uveal melanoma and the 

potential role for adjuvant treatment with COX- 

2 inhibitors. Lindsay E. Adam, J. B. Massengill, C. 

M. Cebulla, M. H. Abdel-Rahman. Ophthalmology, 

The Ohio State University, Columbus, OH 

4213 — B0206 Antimicrobial Peptide 

Expression and Potential Roles in Uveal 

Melanoma Pathogenesis. Joseph C. Manarang, 

D. C. Otteson, A. Glasser, A. R. Burns, A. M. 

McDermott. College of Optometry, University of 

Houston, Houston, TX 

4214 — B0207 Improved Specimen Handling 

for Optimizing Diagnostic Yield from Fine 

Needle Aspiration Biopsy of Uveal Tumors. 

Nieraj Jain, V. M. Elner, H. Demirci. University of 

Michigan, Ann Arbor, MI *CR 

4215 — B0208 Heterogeneity of Monosomy 3 

in Fine Needle Aspiration Biopsy of Choroidal 

Melanoma. Melinda Chang, N. Rao, L. Johnson, T. 

McCannel. Jules Stein Eye Institute, Los Angeles, 

CA 

4216 — B0209 Prognostic FNAB of Uveal 

Melanoma. Arun D. Singh 1, 5 , M. E. Aronow 1 , C. 

V. Biscotti 2 , R. Tubbs 3 , L. Schoenfield 2 , P. Triozzi 4, 

5 

. 1 Ophthalmic Oncology, Cole Eye Institute, 

Cleveland, OH; 2 Anatomic Pathology, Cleveland 

Clinic, Cleveland, OH; 3 Molecular Pathology, 

Cleveland Clinic, Cleveland, OH; 4 Solid tumor 

Oncology, Cleveland Clinic, Cleveland, OH; 

5 

Taussig Cancer Center, Cleveland Clinic, 

Cleveland, OH 

4217 — B0210 Extraocular Extension of 

Uveal Melanoma After Fine Needle Aspiration, 

Vitrectomy, or Open Biopsy. Amy C. Schefler 1 , D. 

Gologorsky 2 , B. Marr 3 , C. L. Shields 4 , I. Zeolite 5 , 

D. H. Abramson 3 . 1 Retina Consultants of Houston, 

Houston, TX; 2 Geisel School of Medicine at 

Dartmouth, Hanover, NH; 3 Ophthalmic Oncology, 

Memorial Sloan-Kettering Cancer Center, New 

York, NY; 4 Oncology Service, Wills Eye Institute, 

Philadelphia, PA; 5 Ophthalmology, Universidad de 

Mendoza, Mendoza, Argentina 

4218 — B0211 A comparison of gene 

expression profiling versus multiplex ligationdependent 

probe amplification in metastatic 

risk prediction in choroidal melanoma. Sarah 

E. Coupland 1 , B. E. Damato 1 , H. Kalirai 1 , M. 

Baudo 1 , C. Bergstrom 2 , J. R. Wells 2 , T. Kivela 3 , H. 

E. Grossniklaus 2 . 1 Pathology, Univ of Liverpool/ 

Sydney Jones Library, Liverpool, United Kingdom; 

2 

Department of Ophthalmology, Emory University 

School of Medicine, Atlanta, GA; 3 Department 

of Ophthalmology, Helsinki University Central 

Hospital, Helsinki, Finland 

4219 — B0212 Prognostic implications of 

GEP class 2 in clinical practice: a single center 

experience with 273 cases. James J. Augsburger, 

Z. M. Correa. Ophthalmology, University of 

Cincinnati, Cincinnati, OH 

4220 — B0213 Choroidal Melanoma 

pronostication: a robust and costless classifying 

system. Nathalie Cassoux 1 , L. Desjardins 1 , C. 

Plancher 2 , B. Asselain 2 , C. Levy-Gabrielle 1 , L. 

Lumbroso-Le Rouic 1 , M. J. Rodrigues 4 , X. Sastre 5 , S. 

Piperno-Neumann 4 , J. Couturier 3 . 1 Ophthalmology, 

Institut Curie, Paris, France; 2 biostatistics, Institut 

Curie, Paris, France; 3 Genetics, Institut Curie, Paris, 

France; 4 Oncology, Institut Curie, Paris, France; 

5 

Pathology, Institut Curie, Paris, France *CR 

4221 — B0214 Relationship between rate of 

choroidal melanoma flattening following plaque 

radiotherapy and GEP class of tumor cells. 

Zelia M. Correa, J. J. Augsburger. Ophthalmology, 

University of Cincinnati, Cincinnati, OH 

4222 — B0215 The role of Osteopontin 

expression in the mechanism of invasion and 

metastasis potential in Uveal Melanoma. Bin 

Li. Beijing Institute of Ophthalmology, Beijing 

TongRen Hospital, Beijing, China 

4223 — B0216 BAP1 mutations in uveal 

melanoma. Anna E. Koopmans 1, 2 , R. M. Verdijk 3 , 

T. van den Bosch 3 , M. M. van den Berg 1, 2 , J. 

Vaarwater 1 , D. Paridaens 4 , E. Kilic 1 , A. de Klein 2 . 

1 

Ophthalmology, Erasmus Medical Centre, 

Rotterdam, Netherlands; 2 Clinical Genetics, 

Erasmus Medical Centre, Rotterdam, Netherlands; 

3 

Pathology, Erasmus Medical Centre, Rotterdam, 

Netherlands; 4 The Rotterdam Eye Hospital, 

Rotterdam, Netherlands 

4224 — B0217 Gender differences and 

estrogen and progesterone receptor expression 

in uveal melanoma. Lynn Schoenfield 1 , T. Plesec 2 , 

E. Downs-Kelly 2 , M. Aronow 3 , P. Carver 2 , R. 

Tubbs 2 , A. D. Singh 3 . 1 Pathology, Ohio State 

University Wexner Medical Center, Columbus, OH; 

2 

Pathology, Cleveland Clinic, Cleveland, OH; 3 Eye 

Institute, Cleveland Clinic, Cleveland, OH 

4225 — B0218 Detection of circulating tumor 

cells in uveal melanoma using the CellSearch ® 

system. Martina Angi 1 , L. Khoja 3, 4 , B. E. Damato 2 , 

P. Lorigan 3 , C. Dive 4 , S. E. Coupland 1 , H. Kalirai 1 . 

1 

Department of Molecular & Clinical Cancer 

Medicine, University of Liverpool, Liverpool, 

United Kingdom; 2 Royal Liverpool University 

Hospital, Liverpool, United Kingdom; 3 The Christie 

NHS Foundation Trust, Manchester, United 

Kingdom; 4 Paterson Institute for Cancer Research, 

Manchester, United Kingdom 


280 

4226 — B0219 Quantification of circulating 

tumour cells in patients with choroidal 

melanocytic tumours: correlation with clinical 

risk factors. Manuel F. Bande 1 , M. Santiago 1 , 

P. Mera 1 , M. Blanco 1 , L. Muinelo-Romay 3 , 

C. Capeans 1 , M. Pardo 2 , A. Piñeiro 1 . 1 Ocular 

Oncology Unit. Servizo de Oftalmoloxía. 

Complexo Hospitalario Universitario de Santiago. 

Universidade de Santiago de Compostela. Santiago 

de Compostela. Spain, Santiago de Compostela, 

Spain; 2 Grupo Obesidómica, Laboratorio de 

Endocrinología Molecular y Celular, Hospital 

Clínico Universitario de Santiago (CHUS/ 

SERGAS), Spain, Santiago de Compostela, 

Spain; 3 Unit of circulating tumor cells analysis. 

Traslational laboratory/ Medical Oncology 

Department. Complexo Hospitalario Universitario 

de Santiago de Compostela Santiago de 

Compostela, Spain., Santiago de Compostela, Spain 

4227 — B0220 Systemic Surveillance for 

Metastases in patients with Uveal Melanoma. 

Maria M. Choudhary 1 , A. Gupta 2 , J. Bena 3 , A. 

D. Singh 2 . 1 Internal Medicine, Cleveland Clinic 

Foundation, Cleveland, OH; 2 Department of 

Ophthalmology, Cleveland Clinic Foundation, 

Cleveland, OH; 3 Quantitative Health Sciences, 

Cleveland Clinic Foundation, Cleveland, OH 

4228 — B0221 Detecting hepatic metastases 

from ocular melanoma using MRI with a 

novel designed contrast agent. Hua Yang 1 , H. E. 

Grossniklaus 1 , Q. Zhang 1 , S. Xue 2 , F. Pu 2 , J. Qiao 2 , 

Z. Liu 2 , R. C. Long 3 , J. Yang 2 . 1 Ophthalmology, 

Emory University Eye Center, Atlanta, GA; 

2 

Chemistry, Georgia State University, Atlanta, GA; 

3 

Radiology, Emory University, Atlanta, GA 

4229 — B0222 In vivo contrast-enhanced 

high-frequency ultrasonography of 

experimental uveal melanoma: imaging 

features and histopathologic correlations. Hans 

E. Grossniklaus, S. J. Kang, Q. Zhang. Dept of 

Ophthal, School of Med, Emory University, Atlanta, 

GA 

4230 — B0223 Enhanced Depth Imaging 

Optical Coherence Tomography of Choroidal 

Melanoma Before and After Plaque 

Radiation Therapy. Denise S. Kim, H. Demirci. 

Ophthalmology & Visual Sciences, University of 

Michigan Kellogg Eye Center, Ann Arbor, MI 

4231 — B0224 Enhanced Depth Imaging 

Optical Coherence Tomography of Tumors of 

the Retina and Choroid: Comparison to B-scan 

ultrasonography. Euiyong Kweon 1, 2 , J. G. Frisch 3 , 

P. G. Hovland 1 . 1 Colorado Retinal Associates, 

Denver, CO; 2 Department of Ophthalmology, 

Chonbuk National University Hospital, Jeonju, 

Republic of Korea; 3 Roocky Vista University 

Medical School, Denver, CO 

4232 — B0225 EDI-OCT Findings in Unilateral 

Choroidal Melanocytosis with Macular 

Involvement. Sruthi Arepalli, M. Pellegrini, C. 

L. Shields. Ocular Oncology, Wills Eye Institute, 

Philadelphia, PA 

4233 — B0226 Macular Choroidal Thickness 

in Uveal Melanoma Patients treated with Plaque 

Radiotherapy. Ira H. Schachar, H. Demirci. 

Ophthalmology, University of Michigan, Ann 

Arbor, MI


4234 — B0227 Radiation Therapy for Small 

Choroidal Melanoma: 10-years Experience 

with Palladium-103 Plaque Radiation Therapy. 

Kimberly J. Chin, E. Semenova, P. T. Finger. The 

New York Eye Cancer Center, New York, NY *CR 

4235 — B0228 Plaque Radiation Therapy for 

Large and Extra-large Choroidal Melanoma. 

Ekaterina Semenova 1, 2 , P. T. Finger 1, 2 . 1 Ocular 

Oncology, The New York Eye Cancer Center, New 

York, NY; 2 Ocular Oncology, The New York Eye 

and Ear Infirmary, New York, NY *CR 

4236 — B0229 Proton beam radiation for the 

treatment of large choroidal melanoma. Shideh 

Schoenfeld. charite Berlin, ophthalmology, Berlin, 

Germany 

4237 — B0230 Outcomes of Choroidal 

Melanomas Treated with Eye Physics ® plaques: a 

20-year Review. Jesse L. Berry 1 , S. V. Dandapani 2 , 

M. Stevanovic 3 , M. Astrahan 2 , A. L. Murphree 4 , J. 

W. Kim 1, 4 . 1 Doheny Eye Institute and Department 

of Ophthalmology, Keck School of Medicine of the 

University of Southern California, Los Angeles, 

CA; 2 Department of Radiation Oncology, Keck 

School of Medicine of the University of Southern 

California, Los Angeles, CA; 3 Harvard College, 

Cambridge, MA; 4 Ophthalmology, The Vision 

Center at Children’s Hospital Los Angeles, Los 


103 

4238 — B0231 Pd versus 125 I Plaque 

Radiation Dose to Normal Ocular Structures 

in the Treatment of 319 Uveal Melanomas. Di 

Zhou 1, 4 , E. Semenova 1, 3 , P. Wong 2 , N. Kalach 2 , W. 

Choi 2, 3 , P. T. Finger 1, 4 . 1 The New York Eye Cancer 

Center, New York, NY; 2 Beth Israel Comprehensive 

Cancer Center, New York, NY; 3 The New York 

Eye and Ear Infirmary, New York, NY; 4 New York 

University School of Medicine, New York, NY *CR 

4239 — B0232 High Dose Rate Interstitial 

Radiation Therapy for Orbital Melanoma. 

Paul T. Finger 1, 3 , L. B. Tena 2 , P. Aridgides 2 , E. 

Semenova 1, 3 , W. Choi 2, 3 . 1 Ophthalmic Oncology, 

The New York Eye Cancer Center, New York, NY; 

2 

Radiation Oncology, Beth Israel Comprehensive 

Cancer Center, New York, NY; 3 Ophthalmology, 

The New York Eye and Ear Infirmary, New York, 

NY *CR 

4240 — B0233 Intravitreal Bevacizumab 

Therapy In the Management of Radiation 

Maculopathy. Andrew W. Stacey, H. Demirci. 

Ophthalmology, University of Michigan - Kellogg 

Eye Center, Ann Arbor, MI 

4241 — B0234 Autocrine impact of VEGF 

ligands in uveal melanoma cells. Konrad R. 

Koch 1 , D. Hos 1 , B. Regenfuss 1 , F. Bock 1 , J. J. 

Bosch 2 , C. Cursiefen 1 , L. M. Heindl 1 . 1 Center of 

Ophthalmology, University of Cologne, Cologne, 

Germany; 2 Department of Internal Medicine 5, 

Hematology and Oncology, University of Erlangen- 

Nuremberg, Erlangen, Germany *CR 

4242 — B0235 Symptomatic Macular 

Melanocytic Lesions Treated with Intravitreal 

Bevacizumab. Jella A. An 1 , C. Corriveau 2 , M. 

Sebag 1, 2 , S. A. Callejo 1, 2 . 1 Ophthalmology, McGill 

University, Montreal, QC, Canada; 2 Ophthalmology, 

Centre Hospitalier de l’Université de Montréal, 

Montreal, QC, Canada *CR 

4243 — B0236 Minimally invasive therapy 

of exudative retinal detachment (ERD) due 

to choroidal or ciliary body melanoma after 

irradiation therapy compared to endoresection. 

Ira Seibel 1 , D. Cordini 2 , G. Willerding-Beaucamp 1 , 

J. Heufelder 2 , A. M. Joussen 1 . 1 Department of 

Ophthalmology, Charité University Medicine, 

Berlin, Germany; 2 Proton beam therapy, Helmholtz- 

Zentrum Berlin für Materialien und Energie - Lise- 

Meitner-Campus, Berlin, Germany 

4244 — B0237 Detection of Extrascleral 

Extension in Uveal Melanoma. Christopher 

Burris 1 , V. Papastefanou 2, 3 , C. Thaung 4 , M. S. 

Sagoo 2, 3 , V. Cohen 2, 3 . 1 Ophthalmology, Howard 

University College of Medicine, Washington, DC; 

2 

Ocular Oncology, St. Bartholomew’s Hospital, 

London, United Kingdom; 3 Ocular Oncology, 

Moorfields Eye Hospital, London, United Kingdom; 

4 

Eye Pathology, UCL Institute of Ophthalmology, 

London, United Kingdom 

4245 — B0238 Extraocular extension in uveal 

melanoma. Jackelien van Beek 1 , A. E. Koopmans 1, 2 , 

J. Vaarwater 2 , A. de Klein 2 , R. M. Verdijk 3 , E. 

Kilic 1, 2 . 1 Ophthalmology, Erasmus MC Rotterdam, 

Rotterdam, Netherlands; 2 Clinical Genetics, 

Erasmus MC Rotterdam, Rotterdam, Netherlands; 

3 

Pathology, Erasmus MC Rotterdam, Rotterdam, 

Netherlands 

4246 — B0239 Ciliary Body and Choroidal 

Pseudomelanoma from Hypermature Cataract 

in 20 Cases. Marco Pellegrini, C. L. Shields, B. 

E. Kligman, C. G. Bianciotto, J. Shields. Ocular 

Oncology Service, Wills Eye Institute, Philadelphia, 

PA 

4247 — B0240 Prevalence of Asteroid Hyalosis 

in Human and Canine Melanoma Eyes. 

Heather Potter 1 , M. Rezaei Kanavi 1, 2 , A. Azari 1 , 

R. R. Dubielzig 1 , D. M. Albert 1 . 1 Ophthalmology, 

University of Wisconsin, Madison, WI; 2 Ophthalmic 

Research Center, Shahid Beheshti University of 

Medical Sciences, Tehran, Islamic Republic of Iran 

*CR 

4248 — B0241 Pain as presenting feature of 

uveal melanoma. Pukhraj Rishi 1, 2 , C. L. Shields 1 , 

K. A. Patrick 1 , M. A. Khan 1 , J. Shields 1 . 1 Ocular 

Oncology Service, Wills Eye Institute, Philadelphia, 

PA; 2 Sankara Nethralya, Chennai, India 

4249 — B0242 Analysis of the quality of life 

of patients receiving conservative treatment for 

uveal melanoma. Federica Genovesi-Ebert 1 , C. 

Meo 2 , F. Perrone 3 , C. Meo 2 , F. Cresti 1 , P. Ferrazza 2 , 

S. Rizzo 1 . 1 U.O. Chirurgia Oftalmica, Azienda 

Ospedaliera Universitaria Pisana, Livorno, Italy; 

2 

Radiotherapy Department, Azienda Ospedaliera 

Universitaria Pisana, Pisa, Italy; 3 Sanitary Physics, 

Azienda Ospedaliera Universitaria Pisana, Pisa, 

Italy 




417 Accommodation and Presbyopia 

Correction 

Moderators: Abhiram S. Vilupuru and 

Fabrice Manns 

4250 — B0287 The Influence of Multifocal 

Lenses on Fine Motor Tasks. Rupal Lovell- 

Patel 1, 2 , M. A. Timmis 2 , S. Pardhan 2 , P. McCarthy 1, 2 . 

1 

Vision and Hearing Sciences, Anglia Ruskin 

University, Cambridge, United Kingdom; 2 Vision 

and Eye Research Unit, Anglia Ruskin University, 

Cambridge, United Kingdom 

4251 — B0288 Accommodative Lag, Facility 

and Phoria with Multifocal Contact Lenses. 

Jiyoon Chung 1 , R. C. Bakaraju 1 , C. Fedtke 1 , J. 

Ozkan 1 , K. Ehrmann 1, 2 , D. Falk 1 , A. Ho 1, 2 , B. A. 

Holden 1, 2 . 1 Brien Holden Vision Institute, Sydney, 

NSW, Australia; 2 School of Optometry and Vision 

Science, University of New South Wales, Sydney, 

NSW, Australia *CR, f 

4252 — B0289 The role of eye dominance 

on through-focus visual performance in 

modified monovision presbyopic corrections. 

Len Zheleznyak 1, 2 , A. Alarcon 2 , K. C. Dieter 3 , 

D. Tadin 3, 2 , G. Yoon 2, 1 . 1 The Institute of Optics, 

University of Rochester, Rochester, NY; 2 Flaum 

Eye Institute, University of Rochester, Rochester, 

NY; 3 Brain and Cognitive Sciences, University of 

Rochester, Rochester, NY *CR 

4253 — B0290 Customizing depth of focus 

outcomes in Hyperopic Lasik using an Adaptive 

Optics Vision Analyzer. Guillermo M. Perez 1 , E. 

A. Villegas 2 , B. Leray 3 , F. J. Malecaze 3 , P. Artal 2 . 

1 

Voptica S.L., Murcia, Spain; 2 Laboratorio de 

Optica, Universidad de Murcia, Murcia, Spain; 

3 

Service d’Ophtalmologie, CHU Toulouse-Purpan, 

Toulouse, France *CR 

4254 — B0291 Effect of Age on Amplitude of 

Accommodation in Bolivia. Magnus Andersson, 

B. Theagarayan. Section of Optometry and Vision 

Science, Linnaeus University, Kalmar, Sweden 

4255 — B0292 Influences of cycloplegia 

with topical cyclopentolate on higher-order 

aberrations in myopic children. Takahiro 

Hiraoka 1 , K. Miyata 2 , F. Okamoto 1 , T. Oshika 1 . 

1 

Dept of Ophthalmology, University of Tsukuba, 

Tsukuba, Japan; 2 Miyata Eye Hospital, Miyakonojo, 

Japan 

4256 — B0293 Five-year Incidence of Loss 

of Accommodative Ability in the Beaver 

Dam Offspring Study. Dayna S. Dalton, K. J. 

Cruickshanks, M. E. Fischer, B. E. Klein, R. Klein, 

A. A. Pinto. Ophthalmology and Visual Sciences, 

University of Wisconsin, Madison, WI 


8:30 am – 10:15 am 


281



8:30 am – 10:15 am 

4257 — B0294 Effect of Unclean Display on 

Accommodative Response. Masakazu Hirota 1 , H. 

Uozato 1, 2 , S. Arai 1 , Y. Shibata 1 . 1 Ophthalmology & 

Visual Sciences, Kitasato Univ Graduate School, 

Minami-ku, Sagamihara-shi, Japan; 2 Orthoptics 

& Visual Sciences, Kitasato University School of 

Allied Health Science, Minami-ku, Sagamihara-shi, 

Japan 

4258 — B0295 The effect of near addition 

lenses on the accuracy of the accommodative 

response in myopic children during reading. 

Jinhua Bao, Z. Zheng, H. Chen. School of 

Optometry and Ophthalmology, Wenzhou Medical 

College, Wenzhou, China 

4259 — B0296 Tonic Accommodation 

Correlates with Accommodative Amplitude- 

Scaled Facility Test for Symptomatic Graduate 

Students. Chunming Liu 1 , C. Chase 1 , S. A. Drew 3 , 

E. Castellanos 1 , A. Escobar 1 , E. Borsting 2 , L. 

R. Stark 2 . 1 Optometry, Western University of 

Health Sciences College of Optometry, Pomona, 

CA; 2 Southern California College of Optometry, 

Fullerton, CA; 3 California State University, 

Northridge, Northridge, CA 

4260 — B0297 Larger Tonic Accommodation 

Correlates with Better Focus at Near for 

Symptomatic Graduate School Students. Chris 

Chase 1 , S. A. Drew 3 , A. Escobar 1 , C. Liu 1 , E. 

Castellanos 1 , L. R. Stark 2 , E. Borsting 2 . 1 College of 

Optometry, Western University of Health Sciences, 

Pomona, CA; 2 Southern California College of 

Optometry, Fullerton, CA; 3 California State 

University, Northridge, Northridge, CA f 

4261 — B0298 The Dynamic Accommodative 

Response with the Binocular open-field 

autorefractor and a Movable Real Target. Shinji 

Arai 1 , H. Uozato 1, 2 , M. Hirota 1 . 1 Department of 

Visual Science, Kitasato University Graduate 

School of Medical Sciences, Kanagawa, Japan; 

2 

Department Orthoptics and Visual Sciences, 

Kitasato University School of Allied Health 

Science, Kanagawa, Japan 

4262 — B0299 Suppression in the 

accommodative response to short-duration 

changes in dioptric stimulus. Alistair P. Curd, 

K. M. Hampson, E. Mallen. Bradford School of 

Optometry and Vision Science, University of 

Bradford, Bradford, United Kingdom 

4263 — B0300 Accommodation induced 

variations of ocular axial length and retinal 

thickness measured with SD-OCT. Chuanqing 

Zhou, S. Fan, Z. Chen, X. Chai. Biomedical 

Engineering, Shanghai Jiao Tong University, 

Shanghai, China 

4264 — B0301 The Effect Of Age On The 

Lens Ultrastructure During Accommodation As 

Measured Using Slit Lamp Photos And Wave 

Front Analysis. Rebecca K. Zoltoski 1 , E. Wyles 1 , 

J. S. Harthan 1 , J. R. Kuszak 2 . 1 Illinois College of 

Optometry, Chicago, IL; 2 LensAR, Orlando, FL 

*CR 

4265 — B0302 Do Higher Order Aberrations 

Affect the Magnitude of Odd-error Temporal 

Stimuli to Accommodation? Sangeetha 

Metlapally 1 , J. Tong 2 , H. J. Tahir 3, 1 , C. M. Schor 1 . 

1 

School of Optometry, University of California at 

Berkeley, Berkeley, CA; 2 Brain Trauma Foundation, 

New York, NY; 3 University of Manchester, 

Manchester, United Kingdom 

4266 — B0303 Impact of pupil amplitude 

apodization on through-focus image quality 

with spherical aberration. Hae Won Jung 1, 2 , L. 

Zheleznyak 1, 2 , G. Yoon 2, 1 . 1 The Institute of Optics, 

University of Rochester, Rochester, NY; 2 Flaum 

Eye Institute, University of Rochester, Rochester, 

NY *CR 

4267 — B0304 Contribution of shape and 

gradient index to the spherical aberration of 

donor human lenses. Judith Birkenfeld, A. de 

Castro, S. Marcos. CSIC-Instituto de Optica, 

Madrid, Spain *CR 

4268 — B0305 Crystalline lens thickness 

determines transverse chromatic aberration. Yun 

Chen, F. Schaeffel. Section of neurobiology of the 

Eye, Institute for Ophthalmic Research, Tuebingen, 

Germany 

4269 — B0306 Prediction of human crystalline 

lens power and spherical aberration using an 

anatomically-based discrete shell model. Fabrice 

Manns 1, 2 , A. Ho 3, 4 , J. A. Parel 1, 5 . 1 Ophthalmic 

Biophysics Center, Bascom Palmer Eye Inst, Univ 

of Miami, Miami, FL; 2 Department of Biomedical 

Engineering, University of Miami College of 

Engineering, Coral Gables, FL; 3 Brien Holden 

Vision Institute, Sydney, NSW, Australia; 4 School 

of Optometry and Vision Science, University of 

New South Wales, Sydney, NSW, Australia; 5 Vision 

Cooperative Research Centre, Sydney, NSW, 

Australia *CR 

4270 — B0307 Age-related Stiffening of 

Human Lens Measured by In Vivo Brillouin 

Microscopy. Sebastien Besner 1, 2 , G. Scarcelli 1, 2 , R. 

Pineda 3 , S. H. Yun 1, 2 . 1 Department of Dermatology, 

Harvard Medical School, Boston, MA; 2 Wellman 

Center for Photomedicine, Massachusetts 

General Hospital, Boston, MA; 3 Department 

of Ophthalmology, Massachusetts Eye and Ear 

Infirmary, Boston, MA *CR 

4271 — B0308 Effect of Temperature on 

Lens Power, Anterior and Posterior Surface 

Lens Curvatures and Force during Simulated 

Accommodation in Cynomolgus Monkeys. Jean- 

Marie A. Parel 1, 3 , B. M. Maceo 1, 2 , C. J. Rowaan 1 , 

F. Manns 1, 2 , E. Arrieta 1 . 1 Ophthalmic Biophysics 

Center, Bascom Palmer Eye Institute, Univ. of 

Miami Miller School of Medicine, Miami, FL; 

2 

Biomedical Optics and Laser Laboratory, Dept of 

Biomedical Engineering, College of Engineering, 

University of Miami, Miami, FL; 3 Vision 

Cooperative Research Centre, Sydney, NSW, 

Australia *CR 

4272 — B0309 Lens Spherical Aberration 

Changes in Cynomolgus Monkeys during 

Simulated Accommodation in a Lens Stretcher. 

Bianca M. Maceo 1, 2 , F. Manns 1, 2 , A. de Castro 3 , S. 

Uhlhorn 1 , E. Arrieta 1 , S. Marcos 3 , J. A. Parel 1, 4 . 

1 

Ophthalmic Biophysics Center, Bascom Palmer 

Eye Institute, Miami, FL; 2 Biomedical Optics 

and Laser Laboratory, Department of Biomedical 

Engineering, University of Miami College of 

Engineering, Coral Gables, FL; 3 Instituto de Óptica, 

Consejo Superior de Investigaciones Científicas, 

Madrid, Spain; 4 Vision Cooperative Research 

Centre, Sydney, NSW, Australia *CR 

4273 — B0310 Comparison between in vivo 

and in vitro age-related loss of accommodation in 

rhesus monkeys. Mark Wendt, A. Glasser. College 

of Optometry, University of Houston, Houston, TX 

4274 — B0311 Age-related loss of 

accommodation in rhesus monkeys is associated 

with an age-related increase in lens stiffness. 

Adrian Glasser, M. Wendt. College of Optometry, 

University of Houston, Houston, TX 

4275 — B0312 Dynamic wavefront 

measurement of accommodation and pupil area 

in response to electric stimulation of ciliary 

nerve in cats. Suguru Miyagawa 1, 2 , T. Mihashi 2, 4 , 

Y. Hirohara 1, 2 , A. Takada 1 , T. Endo 2 , H. Kanda 2 , 

T. Miyoshi 3 , T. Fujikado 2 . 1 Optical Engineering 

Laboratory, Topcon Corporation, Itabashi-Ku, 

Japan; 2 Dept of Applied Visual Science, Osaka 

University Graduate School of Medicine, Suita, 

Japan; 3 Integrative Physiology, Osaka University 

Graduate School of Medicine, Suita, Japan; 

4 

Innovative Research Initiatives, Tokyo Institute of 

Technology, Yokohama, Japan *CR 

4276 — B0313 Macular function contributes 

to the near vision performance in the patients 

with monofocal intraocular lens: a functional 

Multifocal ERG study. Xialin Liu, Y. Ni, C. He, L. 

Wang, Y. Liu. Zhongshan Ophthalmic Center, Sun 

Yat-sen University, Guangzhou, China 

4277 — B0314 Changes in Add Power for Near 

Vision after Laser in Situ Keratomileusis for 

Presbyopic High Myopia. Yukari Tsuneyoshi 1, 3 , K. 

Negishi 1 , M. Yoshida 1 , M. Saiki 1 , N. Kato 1 , I. Toda 2 , 

K. Tsubota 1 . 1 Ophthalmology, Keio University 

School of medicine, Tokyo, Japan; 2 Ophthalmology, 

Minamiaoyama Eye Clinic, Tokyo, Japan; 

3 

Ophthalmology, Tachikawa Hospital, Tachikawa, 

Japan *CR 

4278 — B0315 Subsurface Femto-Laser 

Photodisruption in the Sclera for the Creation 

of Presbyopic Implant Tunnels. Aghapi 

Mordovanakis 1, 2 , L. Baitch 3 . 1 Biomedical 

Engineering, University of Michigan, Ann 

Arbor, MI; 2 Center for Ultrafast Optical Science, 

University of Michigan, Ann Arbor, MI; 3 Research, 

Refocus Group, Dallas, TX *CR 

4279 — B0316 Electro-optic lens for correction 

of presbyopia. Guoqiang Li, T. F. Mauger. Depts 

of Ophthal and Vis Sci and ECE, Ohio State 

University, Columbus, OH *CR 


282


4280 — B0317 Tolerance to astigmatism 

with a small aperture corneal inlay. Abhiram 

S. Vilupuru 1 , J. Tabernero 2 , P. Artal 2 . 1 R&D, 

AcuFocus, Inc, Irvine, CA; 2 Universidad de Murcia, 

Murcia, Spain *CR 

4281 — B0318 Distribution of Achromatizing 

Pupil Positions and First Purkinje Reflections 

in a Normal Population. Silvestre Manzanera 1 , 

J. Tabernero 1 , A. Benito 1 , A. S. Vilupuru 2 , P. M. 

Prieto 1 , P. Artal 1 . 1 Laboratorio de Optica, University 

of Murcia, Murcia, Spain; 2 R&D, AcuFocus, Irvine, 

CA *CR 

4282 — B0319 Visual Simulation of Retinal 

Images with Various Designs of Pinhole Contact 

Lenses using Ray Tracing Software. Kazuno 

Negishi 1 , Y. Nishi 1 , K. Ohnuma 2 , K. Tsubota 1 . 

1 

Department of Ophthalmology, Keio Univ School 

of Medicine, Shinjuku-Ku, Japan; 2 Graduate School 

of Engineering, Chiba Univesity, Chiba, Japan *CR 

4283 — B0320 Visual Simulation of Retinal 

Images with Various Designs of Pinhole 

Contact Lenses. Yasuyo Nishi, K. Negishi, K. 

Watanabe, Y. Hidaka, H. Torii, M. Saiki, K. 

Tsubota. Ophthalmology, Keio University School of 

Medicine, Tokyo, Japan *CR 

Exhibit Hall C0022-C0045 


Physiology/Pharmacology / Cornea 

418 Antibiotics and Corneal Disease 

Moderator: Haydee E. Bazan 

4284 — C0022 The use of predatory 

prokaryotes to control human ocular pathogens. 

Robert M. Shanks 1 , K. To 2 , N. A. Stella 1 , K. M. 

Brothers 1 , R. P. Kowalski 1 , E. G. Romanowski 1 , 

D. E. Kadouri 2 . 1 Ophthalmology, University of 

Pittsburgh, Pittsburgh, PA; 2 Oral Biology, UMDNJ, 

Newark, NJ *CR 

4285 — C0023 Susceptibility of 

Stenotrophomonasmaltophilia to Antibiotics 

and Contact Lens Multipurpose Solutions. Keizo 

Watanabe 1, 2 , H. Zhu 2 , R. Bandara 2 , S. Higaki 1 , 

M. Fukuda 1 , Y. Shimomura 1 , M. D. Willcox 2 , B. A. 

Holden 1 . 1 Ophthalmology, Kinki University Faculty 

of Medicine, Osakasayama, Japan; 2 Brien Holden 

Vision Institute, Sydney, NSW, Australia *CR 

4286 — C0024 A Comparison of Prophylactic 

Antibacterial Efficacy of Besifloxacin 0.6% versus 

Moxifloacin 0.5% at 1 hour and 3 days Prior to 

Phacoemulsification. Frank A. Bucci. Bucci Laser 

Vision Institute, Wilkes-Barre, PA *CR, f 

4287 — C0025 Cytotoxicities of various 

ophthalmic antimicrobial solutions in SV40- 

immortalized human corneal epithelial cells. Jae 

Lim Chung 1 , S. Song 1 , B. Kim 1 , J. H. Lee 2 , K. Seo 3 . 

1 

Konyang University Kim’s Eye Hospital, Seoul, 

Republic of Korea; 2 Myunggok Eye Research 

Institute, Konyang University, Seoul, Republic 

of Korea; 3 Shinchon Severance Hospital, Yonsei 

University, Seoul, Republic of Korea 

4288 — C0026 The In Vitro Activity of 

Tigecycline for Clinically Relevant Ocular 

Pathogens. Regis P. Kowalski, T. Kowalski, 

E. G. Romanowski, R. M. Shanks, L. Raju. 

Ophthalmology/Microbiology, Univ of Pittsburgh, 

Pittsburgh, PA *CR 

4289 — C0027 Tear Osmolarity in Pediatric 

Patients with Cystic Fibrosis. Livio Giulio Marco 

Franco 1 , V. De Grande 1 , S. Stella 1 , M. Reibaldi 1 , 

E. Lionetti 2 , C. Franzonello 2 , S. Leonardi 2 , C. 

Gagliano 1 , A. Russo 1 , M. La Rosa 2 . 1 Institute of 

Ophthalmology, University of Catania, Catania, 

Italy; 2 Department of Pediatrics, University of 

Catania, Catania, Italy 

4290 — C0028 The Pharmacokinetics and 

Aqueous Humor Penetration of Besifloxacin 

0.6% and Moxifloxacin 0.5% in Patients 

Undergoing Cataract Surgery. Ruth Evans, F. A. 

Bucci. Bucci Laser Vision Institute, Wilkes Barre, 

PA *CR, f 

4291 — C0029 Ocular Pharmacokinetics, 

Safety and Efficacy of Intracameral Moxifloxacin 

0.5% Solution in a Rabbit Model. Yonca Akova 1, 2 , 

L. Asena 2 , M. T. Göktas 5 , A. Bozkurt 5 , U. Yasar 5 , 

G. Karabay 4 , E. Demiralay 3 . 1 Ophthalmology, 

Bayindir Kavaklidere Hospital, Ankara, Turkey; 

2 

Ophthalmology, Baskent University Faculty of 

Medicine, Ankara, Turkey; 3 Pathology, Baskent 

University Faculty of Medicine, Ankara, Turkey; 

4 

Histology, Baskent University Faculty of Medicine, 

Ankara, Turkey; 5 Pharmacology, Hacettepe 

University Faculty of Medicine, Ankara, Turkey 

4292 — C0030 High affinity LPS-binding 

branched peptides display synergistic 

activity with other antibiotics. Rajamani 

Lakshminarayanan 1, 2 , S. Liu 1, 2 , R. W. Beuerman 1, 2 . 

1 

Singapore Eye Research Institute, Singapore, 

Singapore; 2 SRP Iin Neuroscience and Behavioral 

Disorders, Duke-NUS Graduate Medical School, 

Singapore, Singapore *CR 

4293 — C0031 The Comparison of Topical 

RPX-978 (an Ophthalmic Formulation of 

Tigecycline) to Topical Vancomycin in a MRSA 

Rabbit Keratitis Model. Eric G. Romanowski, K. 

A. Yates, K. E. O’Connor, F. S. Mah, L. Raju, R. M. 

Shanks, R. P. Kowalski. The Charles T. Campbell 

Laboratory, UPMC Eye Center, University of 

Pittsburgh, Pittsburgh, PA *CR 

4294 — C0032 The Monthly Eye Drop: 

Development of a Long-term, Noninvasive 

Glaucoma Treatment System. Morgan V. 

Fedorchak 1, 2 , A. Cugini 1 , J. S. Schuman 1, 3 , S. R. 

Little 1, 2 . 1 University of Pittsburgh, Pittsburgh, PA; 

2 

McGowan Institute for Regenerative Medicine, 

Pittsburgh, PA; 3 UPMC Eye Center, Pittsburgh, PA 

*CR 

4295 — C0033 Chronic alcohol consumption 

and corneal pathologies: the role of aldehyde 

dehydrogenases. Naseem Ansari 1, 2 , M. Zhang 1 , 

C. Wang 1 , J. Papaconstantinou 1 , V. Vasiliou 3 , B. 

Kaphalia 4 . 1 Biochemistry and Molecular Biology, 

University of Texas Medical Branch, Galveston, 

TX; 2 Ophthalmology & Visual Science, University 

of Texas Medical Branch, Galveston, TX; 

3 

Pharmaceutical Sciences, University of Colorado, 

Aurora, CO; 4 Pathology, University of Texas 

Medical Branch, Galveston, TX 


283 

4296 — C0034 Small non-hydrophobic, 

cationic peptide with in vitro and in vivo efficacy 

against Gram negative bacteria. Roger W. 

Beuerman 1 , S. Liu 2 , R. Lakshminarayanan 3 , J. Li 4 , 

B. Yang 5 . 1 Singapore Eye Research Inst, Singapore, 

Singapore; 2 Singapore Eye Research Institute, 

Singapore, Singapore; 3 Singapore Eye Research 

Institute, Singapore, Singapore; 4 Singapore 

Eye Research Institute, Singapore, Singapore; 

5 


Singapore *CR 

4297 — C0035 Molecular Design of Novel 

Membrane Targeting Antimicrobials with 

Improved Membrane Selectivity Using Natural 

Compound as a Scaffold. Shouping Liu 1, 2 , H. 

Zou 1 , J. Koh 1 , J. Li 3 , R. Lakshminarayanan 1, 2 , R. 

W. Beuerman 1, 2 . 1 Singapore Eye Research Institute, 

Singapore, Singapore; 2 Duke-NUS Medical School, 

SRP Neuroscience and Behavioural Disorders, 

Singapore 169857, Singapore, Singapore; 

3 

Bioinformatics Institute, Singapore 138671, 


4298 — C0036 In vitro analysis of the effect 

of steroid in combination with antimicrobial on 

co-cultures of bacteria and fungi isolated from 

keratitis. Herlinda Mejia-Lopez 1 , L. Y. Martínez- 

López 2 , A. Clinent-Flores 1 , A. V. Rodríguez-Tovar 2 , 

L. A. Bautista-Hernández 1 , V. M. Bautista de 

Lucio 1 , M. A. Martínez-Rivera 2 . 1 Research Unit, 

Inst of Ophthal “Conde de Valenciana”, Mexico 

City, Mexico; 2 Laboratory of Medical Mycology, 

Department of Microbiology, National School of 

Biological Sciences, Instituto Politécnico Nacional, 

México, Mexico 

4299 — C0037 Iontophoresis transcorneal 

delivery technique for transepithelial corneal 

collagen crosslinking with riboflavin in a 

rabbit model. Vincent J. Soler 1, 2 , M. Cassagne 1, 2 , 

C. Laurent 3 , A. Galinier 4 , P. R. Fournie 1, 2 , S. 

Galiacy 1 , P. Roy 5 , F. J. Malecaze 1, 2 . 1 UMRS 563, 

CPTP, Universite Paul Sabatier, Toulouse, France; 

2 

Ophthalmology, Toulouse Purpan Hospital, 

Toulouse, France; 3 Laboratory of Pathology, 

Toulouse Purpan Hospital, Toulouse, France; 

4 

Department of Biochemistry, Toulouse Rangueil 

Hospital, Toulouse, France; 5 Hexamed, Paris, 

France *CR 

4300 — C0038 Comparative Analysis 

of In Vitro Biocompatibility Assays of 

Polyhexamethylene Biguanide Disinfecting 

Contact Lens Multi-Purpose Solutions. Mercedes 

Salvador-Silva 1 , L. C. Huang 1 , J. Cook 2 . 1 Biology 

R&D, Abbott Medical Optics (AMO), Santa Ana, 

CA; 2 Corneal Product Development R&D, Abbott 

Medical Optics (AMO), Santa Ana, CA *CR 

4301 — C0039 Benzalkonium Chloride 

Stimulation of THP-1 Differentiated 

Macrophages in Vitro. Sylvain Michee 1, 2 , F. 

Brignole-Baudouin 2 , L. Riancho 2 , W. H. Rostene 2 , 

C. Baudouin 1, 2 , A. Labbe 1, 2 . 1 department 3, CHNO 

des 15-20, Paris, France; 2 UMRS 968, vision 

institute, PARIS, France 


8:30 am – 10:15 am



8:30 am – 10:15 am 

4302 — C0040 Delayed corneal wound 

healing resulting from the administration 

of fluoroquinolone antibacterial ophthalmic 

solutions and its causes. Masamichi Fukuda, Y. 

Seki, Y. Kurihara, S. Enta, N. Shibata, K. Hagiwara, 

H. Osada, S. Shibata, E. Kubo, H. Sasaki. 

Ophthalmology, Kanazawa Medical University, 

Uchinada, Japan 

4303 — C0041 Penetration of Eye Drop 

Solutions of Fluoroquinolones into the Cornea 

and Anterior Chamber of Human Enucleated 

Eyes. Sidney J. Sousa, G. C. Mendonça. 

Ophthalmology, Univ of Sao Paulo-Sch of Med, 

Ribeirao Preto, Brazil 

4304 — C0042 To evaluate the efficacy of 

corneal collagen crosslinking in fungal corneal 

ulcers. Shah Nawaz, P. K. Maharana, N. Sharma, 

R. B. Vajpayee. Opthalmology, R.P.Centre, AIIMS, 

New Delhi, India 

4305 — C0043 Improvement of post-cataract 

dry eye by 0.05% cyanocobalamine plus 0.5% 

taurine and 0.5% long-chained hyaluronic acid. 

Federico Solignani 1 , M. Zurria 2 , M. Rolando 1, 

3 

. 1 Ophthalmology Dept - Ocular surface disease 

research center, University of Genoa, Genoa, Italy; 

2 

Medical Dept, Alfa Intes Ind Ter Spl srl, Casoria, 

Italy; 3 Is.Pre Oftalmica, Genoa, Italy *CR 

4306 — C0044 Title: Susceptibility Profiles 

in Infectious Keratitis as an Aid in Antibiotic 

Selection. Mark L. Hill, D. A. Friedman, E. Cooper, 

J. Parker. Ophthalmology, UAB, Homewood, AL 

4307 — C0045 Photodynamic antimicrobial 

chemotherapy for methicillin-resistant 

Staphylococcus aureus -in vitro, biofilm, and ex 

vivo bovine keratitis model. Hsiao-sang Chu 1 , F. 

Hu 1 , C. Chen 2, 3 . 1 Department of Ophthlamology, 

National Taiwan University Hospital, Taipei, 

Taiwan; 2 Center for Optoelectronic Biomedicine, 

College of Medicine, National Taiwan University, 

Taipei, Taiwan; 3 Institute of Microbiology and 

Biochemistry, College of Life Science, National 

Taiwan University, Taipei, Taiwan 



Cornea 

419 Dry Eye and Lacrimal Gland IV 

Moderator: Benjamin D. Sullivan 

4308 — C0046 Tear specific potential protein 

biomarker identification by 2D-DIGE based 

proteomics in Dry eye syndrome associated 

with Rheumatoid Arthritis. Narayanasamy 

Angayarkanni 1 , S. Venkata Aluru 2 , U. Tatu 3 , S. 

Agarwal 4 , B. Srinivasan 5 , G. Krishnan Iyer 6 , S. 

M. Rajappa 7 , U. Vetrivel 8 , P. Padmanabhan 9 . 

1 

Biochemistry and Cell Biology, Vision Research 

Foundation, Chennai, India; 2 Biochemistry 

and Cell Biology, Vision Research Foundation, 

Chennai, India; 3 Biochemistry Dept, Indian 

Institute of Science, Bangalore, India; 4 Ocular 

Surface Clinic, Medical Research Foundation, 

Chennai, India; 5 Ocular Surface Clinic, Medical 

Research Foundation, Chennai, India; 6 Ocular 

Surface Clinic, Medical Research Foundation, 

Chennai, India; 7 Cerebrovascular and Vasculitis 

Research Foundation, Chennai, India; 8 Centre 

for Bioinformatics, Vision Research Foundation, 

Chennai, India; 9 Cornea Services, Medical Research 

Foundation, Chennai, India 

4309 — C0047 The Correlation of Muc-16 as 

compared to Dry Eye Clinical Endpoints in Dry 

Eye and Normal Subjects. Michael Watson, K. J. 

Lane, A. Whitlock, G. W. Ousler. Ora, Inc., Andover, 

MA *CR 

4310 — C0048 The Use of Soluble Muc-16 

(CA-125) as a Clinically Relevant Biomarker and 

Endpoint in a Mouse Model of Dry Eye. Jennifer 

Brackett, L. Belen, K. Violette, A. Whitlock. Ora, 

Inc., Andover, MA *CR 

4311 — C0049 Megalin and Cubilin Levels are 

Altered in Tear-Producing Glands of Vitamin D 

Receptor Null Mice. Xiaowen Lu, M. A. Watsky. 

Department of Physiology, University of Tennessee 

Health Science Center, Memphis, TN 

4312 — C0050 Changes in corneal nerve 

morphology and epithelial wound healing 

after prolonged ocular dryness induced by 

lacrimal gland ablation. Kamila Mizerska 1 , N. 

Cuenca 2 , C. Luna 1 , S. Quirce 1 , L. Fernandez- 

Sanchez 2 , I. Kovacs 3 , M. Acosta 1 , C. Belmonte 1 , J. 

Gallar 1 . 1 Instituto de Neurociencias, Universidad 

Miguel Hernandez-CSIC, San Juan de Alicante, 

Spain; 2 Departamento de Fisiología, Genética y 

Microbiología, Universidad de Alicante, Alicante, 

Spain; 3 Department of Ophthalmology, Semmelweis 

University, Budapest, Hungary *CR 

4313 — C0051 Isolation and characterization 

of progenitor cells from intact rabbit lacrimal 

gland. Hong He 1 , G. Sun 1 , H. Lin 1 , M. A. Shatos 2 , 

D. A. Dartt 2 , S. C. Yiu 1, 3 . 1 Wilmer Eye Institute, 

Baltimore, MD; 2 Shepens Eye Research Institute, 

Boston, MA; 3 King Khaled Eye Specialist Hospital, 

Riyadh, Saudi Arabia 

4314 — C0052 Alterations of Tear Functions 

and Ocular Surface Epithelial Differentiation in 

the SOD-1 Knock- out Mouse. Murat Dogru 1, 2 , T. 

Kojima 2, 1 , T. Nagata 2, 1 , A. Igarashi 1, 2 , K. Higa 1, 2 , 

Y. Satake 1 , S. Shimazaki 1 , S. Takahiko 3 , K. Tsubota 2, 

1 

, J. Shimazaki 1 . 1 Ophthalmology, Tokyo Dental 

College, Ichikawa, Japan; 2 Ophthalmology, Keio 

University School of Medicine, Tokyo, Japan; 

3 

Institute of Aging, Chiba University School of 

Medicine, Chiba, Japan *CR 

4315 — C0053 L-carnitine, Erythritol and 

Betaine Suppress the Production and Activity 

of Matrix Metalloproteinases in Primary 

Human Corneal Epithelial Cells Exposed to 

Hyperosmotic Stress. Ruzhi Deng 1, 2 , Z. Su 1, 2 , J. 

Lin 1 , X. Hua 1 , D. Li 1 , S. C. Pflugfelder 1 . 1 Department 

of Ophthalmology, Baylor College of Medicine, 

Houston, TX; 2 Optometry and Ophthalmology, 

Wenzhou Medical College, Wenzhou, China *CR 

4316 — C0054 Suppressive effects of 

17β-estradiol on immortalized human 

meibomian gland epithelial cells. Wendy R. Kam, 

D. A. Sullivan. Schepens Eye Research Institute, 

Massachusetts Eye and Ear, Harvard Medical 

School, Boston, MA *CR 

4317 — C0055 Impact of azithromycin on 

lipid accumulation in immortalized human 

meibomian gland epithelial cells. Yang Liu, W. 

R. Kam, J. Ding, D. A. Sullivan. Schepens Eye 

Research Institute, Massachusetts Eye and Ear, 

Harvard Medical School, Boston, MA *CR 

4318 — C0056 A Comparative Evaluation of 

Lipid-based Formulations for Dry-Eye Therapy 

using a Corneal Epithelial Cell Desiccation 

Model and Physicochemical Measurements. 

Paramita Sarkar, Z. Marlowe, A. Walsh, B. Glass, 

T. Kleiber, M. E. Cavet, K. L. Harrington, S. Davio. 

R&D, Bausch & Lomb, Rochester, NY *CR 

4319 — C0057 Early Clinical Development 

of EBI-005, a Potent Interleukin-1 (IL-1) 

Receptor-1 (R1) Blocker for Topical Ocular 

Treatment of Dry Eye Disease (DED). Michael H. 

Goldstein 1, 2 , G. Zarbis-Papastoitsis 2 , K. Golden 2 , 

S. Chowdhury 2 , C. Wheeler 2 , G. N. Foulks 3 , 

J. T. Kovalchin 2 , J. Agahigian 2 , E. S. Furfine 2 . 

1 

Ophthalmology, New England Eye Center, 

Boston, MA; 2 Eleven Biotherapeutics, Cambridge, 

MA; 3 Ophthalmology, University of Louisville, 

Louisville, KY *CR, f 

4320 — C0058 Preclinical Development of EBI- 

005: a Potent Interleukin-1 (IL-1) Receptor-1 

(R1) Blocker for Topical Ocular Administration 

was Safe in GLP Toxicology Studies and Active 

in a Mouse Model of Dry Eye Disease (DED). 

Eric S. Furfine 1 , K. Collins 1 , D. Escobar 3 , C. Li 2 , P. 

A. Lowden 1 , A. Masci 1 , J. Milling 1 , K. Tenneson 2 , 

G. Wolfe 4 , J. T. Kovalchin 1 . 1 R&D, Eleven 

Biotherapeutics, Cambridge, MA; 2 Charles River 

Laboratories, Senneville, QC, Canada; 3 Intertek, 

San Diego, CA; 4 Gary Wolfe Toxicology LLC, 

Herndon, VA *CR 

4321 — C0059 Soft steroid topical treatment 

for moderate to severe dry eye: pulse vs tapered 

therapy. Edoardo Villani, C. Pirondini, F. Viola, R. 

Ratiglia. UO Oculistica, Univ of Milan Fnd IRCCS 

Ca’ Granda OMP, Milan, Italy 


284


4322 — C0060 Comparison of Three 

Commercially Available Tear Substitutes 

Designed for Evaporative Dry Eye Treatment. 

Charles G. Connor, R. A. Ottenbreit, L. K. 

Schroeder, J. C. Rabin, S. Narayanan. Rosenberg 

School of Optometry, University of the Incarnate 

Word, San Antonio, TX 

4323 — C0061 Plasmacytoid Dendritic Cells 

are the Primary Source of IFN-α During the 

Immunopathogenesis of Desiccating Stress- 

Induced Dry Eye Disease. Michael E. Stern 1 , C. 

S. Schaumburg 1 , J. Gao 1 , A. M. Ratanapinta 1 , V. 

L. Calder 2 , L. A. Wheeler 1 , J. Y. Niederkorn 3 , S. 

C. Pflugfelder 4 , B. Beutler 5 , A. N. Theofilopoulos 6 . 

1 

Biological Sciences, Allergan, Inc, Irvine, CA; 

2 

Ophthalmology, University College London, 

London, United Kingdom; 3 Ophthalmology, 

University of Texas Southwestern Medical School, 

Dallas, TX; 4 Ophthalmology, Baylor University 

College of Medicine, Houston, TX; 5 Center for 

the Genetics of Host Defense, University of 

Texas Southwestern Medical School, Dallas, 

TX; 6 Immunology & Microbial Science, Scripps 

Research Institute, La Jolla, CA *CR 

4324 — C0062 Analysis of Tear Inflammatory 

Mediators: A comparison of Microarray and 

Luminex In Differing Subject Groups. Karen 

Dionne, K. K. Nichols, A. M. McDermott, R. L. 

Redfern, J. J. Nichols. College of Optometry, 

University of Houston, Houston, TX *CR 

4325 — C0063 Tear film cytokine analyses 

using a novel electrochemiluminescent array 

technique. Lakshman N. Subbaraman, M. 

Thangavelu, D. J. McCanna, L. W. Jones. CCLR, 

School of Optometry, University of Waterloo, 

Waterloo, ON, Canada *CR 

4326 — C0064 Secretory Group Two A 

Phospholipase (sPLA2) Inhibition Decreases 

Corneal Superficial Punctate Keratitis (SPK) in 

Dry Eye Mice. Yi Wei, P. Li, J. Zou, S. P. Epstein, 

N. Gadaria-Rathod, P. A. Asbell. Ophthalmology, 

Mount Sinai School of Med, New York, NY *CR 

4327 — C0065 New recombinant hyaluronic 

acid for eye care and ophthalmic drug delivery. 

Birgit Lundskov Fuhlendorff, K. Schwach- 

Abdellaoui, F. Longin, C. Eenschooten. Novozymes 

Biopharma DKA/S, Bagsvaerd, Denmark *CR 

4328 — C0066 Preliminary Studies Of 

Liposomal Formulation Containing An 

Omega-3 Fatty Acid For Dry Eye Therapy. 

Marta Vicario de la Torre 1 , O. Avelino Cruz 1 , 

M. Caballo Gonzalez 1 , B. de las Heras 2 , J. M. 

Benitez-del-Castillo 3 , R. Herrero-Vanrell 1 , I. T. 

Molina-Martínez 1 . 1 Pharmacy and Pharmaceutical 

Technology, Faculty of Pharmacy, Complutense 

University, Madrid, Spain; 2 Pharmacology, Faculty 

of Pharmacy, Complutense University, Madrid, 

Spain; 3 Unidad Superficie e Inflamación Ocular, 

Instituto de Investigacaión Sanitaria, Hospital 

Clínico San Carlos, Madrid, Spain 

4329 — C0067 Clinical Comparison of Lipidbased 

and Aqueous Lubricant Eye drops. Peter 

A. Simmons, C. Carlisle, G. Shi, J. G. Vehige. 

Clinical Research, Allergan, Inc, Irvine, CA *CR, f 

4330 — C0068 Autologous Serum Eye Drop is 

safe and Effective for Treatment of Dry Eyes in 

Graft-versus-host Disease. Amir Azari, M. Rezaei 

Kanavi, H. Potter, P. Hematti. Ophthalmology, 

University of Wisconsin, Madison, WI 

4331 — C0069 Ocular Surface Disease 

Characteristics in Patients with Ocular 

Graft-versus-Host Disease (GVHD). Hasanain 

Shikari 1, 2 , U. S. Saboo 1, 2 , R. Dana 1, 2 . 1 Cornea and 

Refractive Surgery, Massachusetts Eye and Ear 

Infirmary, Harvard Medical School, Boston, MA; 

2 

Schepens Eye Research Institute, Harvard Medical 

School, Boston, MA *CR 

4332 — C0070 Relationships among Tear Film 

Stability, Tear Osmolarity, Corneal Staining 

History, and Dryness Symptoms. Thao N. Yeh 1 , N. 

Tran 1 , A. D. Graham 1 , H. M. Green 2 , M. C. Lin 1, 2 . 

1 

Clinical Research Center, School of Optometry, 

University of California, Berkeley, Berkeley, CA; 

2 

School of Optometry, University of California, 

Berkeley, Berkeley, CA *CR 

4333 — C0071 Handheld Tear Film Lipid 

Layer Thickness and Non Invasive Tear Break 

Up Time Assessment Tool. Igor Petricek. 

Ophthalmology, Clinical Hospital Zagreb, Zagreb, 

Croatia 

4334 — C0072 Does the Phenol Red Thread 

test and the Schirmer test measure the same 

thing? J. Peter Gierow, S. Andersson. School of 

Natural Science, Linnaeus University, Kalmar, 

Sweden 

4335 — C0073 Limbal capillary perfusion and 

blood flow velocity as a potential biomarker for 

evaluating dry eye. Jianhua Wang 1 , H. Jiang 1 , 

A. Tao 1, 2 , D. DeBuc 1 , Y. Shao 2, 1 , J. Zhong 3, 1 , S. 

Pineda 1 . 1 Ophthalmology, Bascom Palmer Eye Inst 

Lib, Miami, FL; 2 Ophthalmology and Optometry, 

School of Ophthalmology and Optometry, Wenzhou 

Medical College, Wenzhou, China; 3 Ophthalmology, 

Hangzhou First People’s Hospital, Hangzhou, China 

*CR 

4336 — C0074 Real World Analytical 

Performance of the TearLab Osmolarity System 

with an Enhanced Temperature Sensor. Benjamin 

D. Sullivan, S. G. Zmina, M. G. Zmina, M. S. Berg. 

TearLab Corp, San Diego, CA *CR 

4337 — C0075 Evaluation of the Validity of the 

Diagnostic Criteria for Dry Eye in Japan Using 

Subjective Symptoms: Osaka Study. Norihiko 

Yokoi 1 , M. Uchino 2 , Y. Uchino 2 , M. Dogru 2 , M. 

Kawashima 2 , A. Komuro 1 , Y. Sonomura 1 , H. Kato 1 , 

K. Tsubota 2 , S. Kinoshita 1 . 1 Ophthalmology, Kyoto 

Prefectural University of Medicine, Kyoto, Japan; 

2 

Ophthalmology, Keio University School of 

Medicine, Tokyo, Japan *CR 

4338 — C0076 Progression of Ocular Findings 

(PROOF) Study of the Natural History of 

Dry Eye: Study Design and Baseline Patient 

Characteristics. Peter J. McDonnell 1 , S. 

Pflugfelder 2 , R. M. Schiffman 3 , D. R. Hardten 4 , 

M. E. Stern 3 , T. Conway 3 , D. A. Hollander 3 . 

1 

Ophthalmology, Johns Hopkins Wilmer Eye Inst, 

Baltimore, MD; 2 Baylor College of Medicine, 

Houston, TX; 3 Allergan, Inc., Irvine, CA; 

4 

Minnesota Eye Consultants, Minneapolis, MN 

*CR, f 

4339 — C0077 Prevalence of dry eye subtypes 

and severity of evaporative dry eye using 

objective tests. Milton M. Hom 1 , J. T. Kwan 2 . 

1 

Private Practice, Azusa, CA; 2 Southern California 

College of Optometry, Fullerton, CA *CR 

4340 — C0078 Relating Improvements in 

Signs and Symptoms to Duration of Dry Eye 

Disease (DED) after Treatment with MIM-D3 

Ophthalmic Solutions. Karen Meerovitch 1, 3 , 

T. Lama 1 , D. A. Schaumberg 2, 4 . 1 Mimetogen 

Pharmaceuticals, Montreal, QC, Canada; 2 Division 

of Preventive Medicine, Brigham & Women’s 

Hospital, Harvard Medical School, Boston, MA; 

3 

Department of Pharmacology and Therapeutics, 

McGill University, Montreal, QC, Canada; 

4 

Department of Ophthalmology and Visual 

Sciences, University of Utah School of Medicine, 

Salt Lake City, UT *CR, f 

4341 — C0079 Automated Detection and 

Enumeration of Corneal Superficial Punctate 

Keratitis. John D. Rodriguez 1 , P. Johnston 1 , K. J. 

Lane 1 , G. W. Ousler 2 . 1 R & D, Ora, Inc., Andover, 

MA; 2 Ora, Inc., Andover, MA *CR 

4342 — C0080 Ocular Surface Disease 

prevalence in Glaucoma patients in a High 

Referral Ophthalmology Center in Mexico City. 

Nallely Ramos-Betancourt 1 , J. D. Martinez 1 , F. 

Beltran 1 , J. Ozorno-Zarate 1 , C. G. Isida Llerandi 2 , 

J. Jimenez-Roman 2 , F. Gil Carrasco 2 , M. Ramirez 1 , 

E. Hernandez-Quintela 1 . 1 Cornea, Asociacion 

Para Evitar la Ceguera, Mexico City, Mexico; 

2 

Glaucoma, Asociación Para Evitar la Ceguera en 

México, Mexico City, Mexico 

4343 — C0081 High CAE Responders Show 

Greater Improvement in Signs and Symptoms of 

Dry Eye after Treatment with MIM-D3. George 

W. Ousler 1 , K. Meerovitch 2 . 1 Ora, Inc., Andover, 

MA; 2 Mimetogen Pharmaceuticals, Montreal, QC, 

Canada *CR, f 

4344 — C0082 Dietary DHA Abrogate Intrinsic 

Sex-Specific Differences in Lacrimal Gland Lipid 

Mediator Circuits during Dry Eye. Kyle M. Hu, S. 

B. Wang, E. Lu, P. J. Salveson, Y. Gao, K. Gronert. 

Vision Science, University of California Berkeley, 

Berkeley, CA 

4345 — C0083 Analysis of Electrolyte 

Composition of Precorneal Tear Film in Normal 

Dogs and Horses and its Comparative Values in 

Serum and Plasma. Gil Ben-Shlomo, L. N. Taylor. 

Veterinary Clinical Sciences, College of Veterinary 

Medicine, Iowa State University, Ames, IA 


8:30 am – 10:15 am 


285



8:30 am – 10:15 am 

4346 — C0084 Decreased Tear Production 

in Dogs Following Phacoemulsification. R 

D. Whitley 1 , H. E. Visser 2 , K. L. Tofflemire 1 , E. 

M. Whitley 3 , R. A. Allbaugh 1 , G. Ben-Shlomo 1 . 

1 

Veterinary Clinical Sciences, Iowa State University, 

Ames, IA; 2 University of Georgia, Athens, GA; 

3 

Veterinary Pathology, Iowa State University, Ames, 

IA 

4347 — C0085 Impact of dry eye on reading 

in a population based sample of the elderly: 

the Salisbury Eye Evaluation. Suzanne W. van 

Landingham, S. K. West, E. K. Akpek, B. E. Munoz, 

P. Y. Ramulu. Wilmer Eye Institute, Johns Hopkins 


4348 — C0086 Tear film osmolarity in rosacea 

patients. Sabah Judith 1 , M. J. Mannis 1 , B. Durbin- 

Johnson 2 , S. Azadmanesh Samimi 3 . 1 Ophthalmology, 

UC Davis Health System, Sacramento, CA; 

2 

Department of Public Health Sciences, UC 

Davis, Davis, CA; 3 UC Davis School of Medicine, 

Sacramento, CA 

4349 — C0087 The Severity of Dry Eye with 

Computer Usage and Serum Lipid Levels. Laura 

A. Norris, Z. B. Martindale, T. V. Mai-Tran, A. Z. 

Chuang, R. W. Yee. Ophthalmology, The University 

of Texas Health Science Center at Houston, 

Houston, TX *CR 

4350 — C0088 Royal jelly prevents lacrimal 

hypofunction in Rat Visual Display Terminal 

Users Model. Toshihiro Imada, S. Nakamura, 

R. Hisamura, K. Tsubota. Ophthalmology, Keio 

university, Shinjyukuku, Japan *CR 

4351 — C0089 Development of a Chinese 

version of the Ocular Comfort Index: 

preliminary validation findings. Cecilia Chao 1 , B. 

Golebiowski 1 , D. Y. Cui 2 , F. Stapleton 1 . 1 School of 

Optometry and Vision Science, The University of 

New South Wales, Sydney, NSW, Australia; 2 Brien 

Holden Vision Institute, The University of New 

South Wales, Sydney, NSW, Australia *CR 

4352 — C0090 Clinical Research of Using 

Oculus Keratograph for Observing the Location 

of First Tear Film Break-up Point. Dan Wu, 

J. Hong, J. Xu. EENT hospital of Fudan Uni., 


4353 — C0091 Allgrove Syndrome: complex 

eye involvement and first evaluation by laser 

scanning confocal microscopy. Angelica Dipinto 1 , 

P. Fogagnolo 2 , D. Allegrini 1 , M. Digiuni 1 , L. 

Migliavacca 1 , C. Pierrottet 1 , L. Ottobelli 1 , O. 

Oneta 1 , L. M. Rossetti 1 . 1 Eye Clinic, San Paolo 

Hospital, Milan, Italy; 2 G.B. Bietti Foundation 

IRCCS, Rome, Italy 

4354 — C0092 How Does Increasing Ocular 

Surface Stimulation Affect Blinking? Ziwei Wu 1 , 

C. G. Begley 1 , P. Situ 1 , A. J. Winkeler 1 , J. Zhang 1 , 

T. L. Simpson 2 . 1 Optometry, Indiana University, 

Bloomington, IN; 2 Optometry and Vision Science, 

University of Waterloo, Waterloo, ON, Canada *CR 

4355 — C0093 Do Tear Film Thinning Rates 

Vary Locally? Adam J. Winkeler 1 , C. G. Begley 1 , 

R. J. Braun 2 , R. Welch 1 . 1 School of Optometry, 

Indiana University, Bloomington, IN; 2 Mathematics, 

University of Delaware, Newark, DE *CR 

4356 — C0094 Longitudinal Mixed Effect 

OSDI Model in a Select Dry Eye Patient 

Population after Acupuncture Treatment. 

Vanessa Bowlin 1 , S. S. Samudre 1 , D. K. Dhaliwal 2 . 

1 

Clinical Research, Eastern Virginia Eye Institute, 

Chesapeake, VA; 2 School of Medicine, University 

of Pittsburgh, Pittsburgh, VA *CR 

4357 — C0095 The relationship of depression 

and anxiety with dry eye subtypes. Louis 

Tong 1, 3 , L. Hong 4 , R. Lee 4 , Y. Zhao 4 , S. C. Sung 2 , 

P. P. Chiang 4 . 1 Cornea and External Eye Disease 

Service, Singapore National Eye Ctr, Singapore, 

Singapore; 2 Office of Clinical Science, Duke-NUS 

graduate medical school, Singapore, Singapore; 

3 

Ophthalmology, Yong Loo Lin School of Medicine, 

National University of Singapore, Singapore, 

Singapore; 4 Singapore Eye Research Institute, 

Singapore, Singapore 

4358 — C0096 The effect of tear lipid 

biochemistry on tear evaporation rate during 

contact lens wear. Athira Rohit 1, 2 , S. H. Brown 3, 1 , 

M. D. Willcox 2, 1 , F. Stapleton 1, 2 . 1 Optometry, Brien 

Holden Vision Institute, Sydney, NSW, Australia; 

2 

Optometry, School of Optometry and Vision 

Science, Sydney, NSW, Australia; 3 School of Health 

Sciences, University of Wollongong, Wollongong, 

NSW, Australia *CR 

4359 — C0097 Evaluation of a Modification of 

the Brief Pain Inventory (BODI) as a Measure 

of Severity of Dry Eye Disease. Maxwell Pistilli 1 , 

E. Peskin 1 , H. S. Brader 1 , P. Dentone 2 , M. G. 

Maguire 1 , P. A. Asbell 2 . 1 Ophthalmology, University 

of Pennsylvania, Philadelphia, PA; 2 Ophthalmology, 

Mount Sinai School of Medicine, New York, NY 

*CR 

4360 — C0098 Correlations between nonstimulated 

tear levels and conjunctival surface 

expression of inflammation-related biomarkers 

in normal and aqueous-deficient dry eye 

patients. Roderick J. Fullard 1 , J. L. Bradley 1 , L. 

D. Williams 1 , M. K. Tran 1 , N. M. Guyette 1 , T. P. 

Than 2 , P. J. Shin 1 . 1 Vision Sciences, University 

of Alabama at Birmingham, Birmingham, AL; 

2 

Optometry, University of Alabama at Birmingham, 

Birmingham, AL 

4361 — C0099 Correlations of Signs and 

Symptoms in Subjects with Dry Eye. Sunita 

Saigal, P. Johnston, L. Smith. Ora, Inc., Andover, 

MA *CR 

4362 — C0100 Transcultural validation of 

the 5-Item Dry Eye Questionnaire (DEQ-5) 

for Mexican population. Everardo Hernandez- 

Quintela 1, 2 , N. Ramos-Betancourt 1, 2 , J. D. 

Martinez 1, 2 , C. Santacruz Valdes 4, 2 , F. Beltran 1, 2 , 

C. Ramírez-Assad 1, 2 , E. M. Mora Juarez 1, 2 , 

A. Babayan 3, 2 . 1 Cornea y Cirugia Refractiva, 

Association Para Evitar la Ceguera, Mexico City, 

Mexico; 2 Colegio Nacional de Investigacion 

en Ciencias Visuales, MARVO, Mexico City, 

Mexico; 3 Cornea y Cirugia Refractiva, Hospital 

Fundacion Nuestra Señora de la Luz, Mexico City, 

Mexico; 4 Cornea y Cirugia Refractiva, Instituto de 

Oftalmologia Conde de Valenciana, Mexico City, 

Mexico 

Exhibit Hall D0001-D0020 


Eye Movements / Strabismus / Amblyopia / 

Neuro-Ophthalmology 

420 Neuro-Ophthalmology: 

Papilledema, Characterization of Rare 

Diseases, and Methods of Evaluation 

Moderator: Raghu C. Mudumbai 

4363 — D0001 Etiologies and visual outcomes 

in secondary pediatric intracranial hypertension. 

William Rhoades 1, 2 , G. Heidary 2 . 1 Ophthalmology, 

Boston University Medical Center, Boston, MA; 

2 

Ophthalmology, Children’s Hospital Boston, 

Boston, MA 

4364 — D0002 Changes of Choroidal 

Thickness as Measured with Spectral Domain 

OCT in Patients with Idiopathic Intracranial 

Hypertension after Lowering of Intracranial 

Pressure. Berthold Pemp, K. Kircher, A. Reitner, 

U. Schmidt-Erfurth. Department of Ophthalmology, 

Medical University of Vienna, Vienna, Austria *CR 

4365 — D0003 Smoking associated with 

cerebrospinal fluid shunt in patients with 

idiopathic intracranial hypertension. Fran L. 

Wu, M. S. Lee. Department of Ophthalmology and 

Visual Neurosciences, University of Minnesota, 

Saint Paul, MN 

4366 — D0004 Correlation of Change in 

Ocular Pulse Amplitude with Change in 

Intracranial Pressure after Lumbar Puncture. 

Keerthana Bolisetty 1 , C. J. Roberts 2, 3 , A. M. 

Mahmoud 2, 3 , M. Okon 3 , S. E. Katz 2, 3 . 1 College of 

Medicine, The Ohio State University, Columbus, 

OH; 2 Ophthalmology, The Ohio State University, 

Columbus, OH; 3 Biomedical Engineering, The Ohio 

State University, Columbus, OH *CR 

4367 — D0005 Changes in Intracranial 

Pressure (ICP) and Ocular Pulse Amplitude 

(OPA) in Patients with Idiopathic Intracranial 

Hypertension (IIH). Steven E. Katz 1, 2 , A. M. 

Mahmoud 1, 2 , M. Okon 2 , K. Bolisetty 3 , R. H. 

Small 4, 2 , C. J. Roberts 1, 2 . 1 Ophthalmology, The 

Ohio State University, Columbus, OH; 2 Biomedical 

Engineering, The Ohio State University, Columbus, 

OH; 3 College of Medicine, The Ohio State 

University, Columbus, OH; 4 Anesthesiology, The 

Ohio State University, Columbus, OH *CR 

4368 — D0006 Evaluation of Inner Retinal 

Thicknesses in the Macula of Patients with 

Chronic Papilledema from Pseudotumor Cerebri 

Syndrome Using Frequency Domain OCT. 

Clara L. Afonso 1 , A. S. Raza 2 , D. B. Fernandes 1 , D. 

C. Hood 2 , M. L. Monteiro 1 . 1 Ophthalmology, FM 

USP, São Paulo, Brazil; 2 Psychology, Columbia 

University, New York, NY *CR 

4369 — D0007 SD-OCT in monitoring 

intracranial pressure in patients with CSF 

shunts. Ali Torab Parhiz 1 , P. A. Sibony 1 , M. J. 

Kupersmith 2 . 1 Ophthalmology, SUNY at Stony 

Brook, Stony Brook, NY; 2 Ophthalmology, New 

York Eye and Ear Infirmary, New York, NY 


286


4370 — D0008 Measurement of Retinal Nerve 

Fiber Layer Thickness in Eyes with Optic Disc 

Swelling by Using Scanning Laser Polarimetry 

and Optical Coherence Tomography. Masayuki 

Hata, K. Miyamoto, A. Oishi, N. Yoshimura. Kyoto 

University Graduate School of Medicine, Kyoto, 

Japan *CR 

4371 — D0009 Correlation of Peripapillary 

Retinal Nerve Fiber Layer Thickness and 

Macular Thickness as Measured by Spectral 

Domain Optical Coherence Tomography in 

Patients with Severe Vision Loss in End Stage 

Optic Neuropathy. Joseph P. Sheehan, C. E. 

Francis, L. Ding, R. C. Mudumbai. Ophthalmology, 

University of Washington, Seattle, WA 

4372 — D0010 Teaching Ophthalmoscopy to 

Medical Students: The TOTeMS Study. Philip S. 

Garza 1 , L. P. Kelly 1 , B. B. Bruce 2 , E. B. Graubart 1 , 

N. J. Newman 3 , V. Biousse 2 . 1 Ophthalmology, 

Emory University, Atlanta, GA; 2 Ophthalmology 

and Neurology, Emory University, Atlanta, GA; 

3 

Ophthalmology, Neurology, and Neurological 

Surgery, Emory University, Atlanta, GA 

4373 — D0011 Evaluation of localization test 

under simulated very low vision conditions. 

Takao Endo 1 , T. Fujikado 2 , H. Kanda 2 , T. 

Morimoto 2 , S. Kitazawa 3 , K. Nishida 1 . 1 Department 

of Ophthalmology, Osaka University Graduate 

School of Medicine, Osaka city, Japan; 2 Department 

of Applied Visual Science, Osaka University 

Graduate School of Medicine, Osaka city, Japan; 

3 

Frontiers Biosciences, Osaka University Graduate 

School of Medicine, Osaka city, Japan *CR 

4374 — D0012 Pupil Size Dynamics During the 

First Minutes of Dark Adaptation While Fixating 

on a Target. Boris I. Gramatikov, K. Irsch, D. L. 

Guyton. Ophthalmology, Johns Hopkins Wilmer 

Eye Institute, Baltimore, MD *CR 

4375 — D0013 Effects of Age on the Peripheral 

60-4 Test Comparing Stimulus Sizes III, V, and 

VI. Jordan Haas 1, 2 , C. K. Doyle 1, 2 , C. A. Johnson 2 , 

M. Wall 1, 2 . 1 Ophthalmology, Iowa City VA 

Healthcare System, Iowa City, IA; 2 Ophthalmology 

and Visual Sciences, University of Iowa, Carver 

College of Medicine, Iowa City, IA *CR 

4376 — D0014 A method of assessing global 

motion perception in two-year old children 

using the optokinetic reflex. Tzu-Ying Yu 1 , R. J. 

Jacobs 1 , N. S. Anstice 1 , N. Paudel 1 , J. E. Harding 2 , 

B. Thompson 1 . 1 Optometry and Vision Science, 

University of Auckland, Auckland, New Zealand; 

2 

Liggins Institute, University of Auckland, 

Auckland, New Zealand *CR 

4377 — D0015 Comparison of Diopsys Pattern 

Reversal Visual Evoked Potential Responses and 

Grating Acuity Measurements using the Teller 

Acuity Card Procedure. Tina K. Green 1 , J. D. 

Twelker 1, 2 , T. R. Kramer 1 , D. J. Mercer 3 , C. Ober 4 , 

C. C. Donaldson 1 , H. Miller 1 , J. M. Miller 1, 2 , E. 

M. Harvey 1, 2 . 1 Ophthalmology and Vision Science, 

University of Arizona, Tucson, AZ; 2 College of 

Public Health, University of Arizona, Tucson, AZ; 

3 

Watching Over Mothers & Babies Foundation, 

Tucson, AZ; 4 Save the Cord Foundation, Tucson, 

AZ *CR 

4378 — D0016 Prospective study on the 

contribution of MRI in the analysis of isolated 

mydriasis: a new kind of neurovascular conflict. 

Fanny Tréchot 1 , M. Braun 2 , V. Cloche 1 , K. Angioi 1 . 

1 

Department of Ophthalmology, Chu Nancy 

Hopitaux De Brabois, Vandoeuvre-les-Nancy, 

France; 2 Department of Neuroradiology, Chu Nancy 

Hopital CentraL, Nancy, France 

4379 — D0017 Sweep-VEP Acuity as a Clinical 

Tool in the Diagnosis of Functional Visual Loss. 

Paula Y. Sacai, A. Berezovsky, D. M. Rocha, S. 

E. Watanabe, J. M. Pereira, N. N. Cavascan, 

T. D. Soares, S. R. Salomao. Ophthalmology, 

Universidade Federal de São Paulo, São Paulo, 

Brazil 

4380 — D0018 Visual field defects and retinal 

nerve fibre layer thickness measurements 

using optical coherence tomography in 

migraine patients. Anna Midelfart 1, 2 , H. 

Bjurstrøm 5 , S. Sollie 5 , E. Midelfart 3 , S. Midelfart 4 . 

1 

Ophthalmology, Norwegian Univ of Sci & Tech, 

Trondheim, Norway; 2 Ophthalmology, University 

Hospital, Trondheim, Norway; 3 Neurology, 

Spesialhelsetjenesten, Trondheim, Norway; 4 Public 

Health and General Practice, Norwegian University 

of Sci and Tech, Trondheim, Norway; 5 Faculty of 

Medicine, Norwegian University of Sci and Tech, 

Trondheim, Norway 

4381 — D0019 Distinctive Clinical Signs 

Differentiating Oculopharyngeal Muscular 

Dystrophy from Myasthenia Gravis. Jeffrey 

Peterson, M. T. Yen, R. Foroozan. Department 

of Ophthalmology, Cullen Eye Institute, Baylor 

College of Medicine, Houston, TX *CR 

4382 — D0020 Ocular Manifestations 

and Optic Nerve Changes in Patients with 

Amyotrophic Lateral Sclerosis (ALS). Joseph 

Simonett, J. Chou, N. Siddique, J. L. Armstrong, A. 

A. Fawzi, T. Siddique, N. J. Volpe. Northwestern 

University, Chicago, IL *CR 



Clinical/Epidemiologic Research 

421 Eye Care 

Moderators: Joshua D. Stein and 

Graham E. Trope 

4383 — D0021 Screening of Potentially 

Blinding Eye Diseases by Vision Technicians at 

Rural Vision Centres in Southern India and their 

Referral Agreement with an Ophthalmologist. 

Uday Addepalli 1 , S. Vasantha 2 , R. C. Khanna 3 , K. 

Sannapaneni 3 , V. Kovai 3 . 1 VST Center for Glaucoma 

Services, L V Prasad Eye Insititute, Hyderabad, 

India; 2 Glaucoma, Sarojini Devi Eye Hospital, 

Hyderabad, India; 3 Allen Foster Research Centre 

for Community Eye Health, International Centre for 

Advancement of Rural Eye care, L V Prasad Eye 

Insititute, Hyderabad, India 

4384 — D0022 Geographic Variability In The 

Age Of First Cataract Surgery And Rate Of 

Cataract Surgery Among Persons Living In 

Communities Throughout The U.S. Courtney Y. 

Kauh, T. S. Blachley, P. R. Lichter, P. P. Lee, J. D. 

Stein. Ophthalmology and Visual Sciences, The 

University of Michigan, Ann Arbor, MI *CR 

4385 — D0023 Power & type II errors in 

recently published ophthalmology research. 

Zainab Khan, C. Milko, A. K. Kurji, M. Iqbal, D. 

Almeida. Ophthalmology, Queen’s University, 

Kingston, ON, Canada 

4386 — D0024 A Longitudinal Analysis of 

1,660 Recipients of Bilateral Laser Peripheral 

Iridotomies to Determine Subsequent Need for 

Cataract Surgery and Additional Interventions 

for Glaucoma. Sharmini Balakrishnan, T. 

S. Blachley, J. Weizer, P. P. Lee, J. D. Stein. 

Ophthalmology, University of Michigan Kellogg 

Eye Center, Ann Arbor, MI *CR 

4387 — D0025 Are Chronic Users of 

Chloroquine or Hydroxychloroquine Undergoing 

Regular Visits to Eye Providers and Diagnostic 

Testing to Check for Maculopathy? Melisa 

Nika 1 , T. S. Blachley 1 , P. A. Edwards 2 , P. P. 

Lee 1 , J. D. Stein 1 . 1 Ophthalmology and Visual 

sciences, Kellogg Eye Center, Ann Arbor, MI; 

2 

Ophthalmology and Visual sciences, Henry Ford, 

Detroit, MI *CR 

4388 — D0026 Optimizing cost-effectiveness 

analyses of treatments for neovascular agerelated 

macular degeneration using real-life 

data. Robert P. Finger 1, 2 , A. Hsueh 1 , J. E. Keeffe 1 , 

R. H. Guymer 1 . 1 Ophthalmology, Centre for Eye 

Research Australia, Melbourne, VIC, Australia; 

2 

Ophthalmology, University of Bonn, Bonn, 

Germany *CR 

4389 — D0027 Comparison of Resource 

Consumption in Penetrating versus Endothelial 

Keratoplasty from 2009-2010. Duna Raoof- 

Daneshvar, R. M. Shtein, T. S. Blachley, M. A. 

Woodward, S. I. Mian, A. Sugar, J. D. Stein. 


Arbor, MI *CR 


8:30 am – 10:15 am 


287



8:30 am – 10:15 am 

4390 — D0028 The Sight Loss and Vision 

Priority Setting Partnership (SLV-PSP) - initial 

survey methods, respondents’ demographics 

and preliminary categorisation framework. 

Michael Bowen 1, 2 , M. Acton 5 , D. M. Conroy 5 , R. 

P. Wormald 10, 3 , A. Lightstone 8, 9 , K. Cowan 7 , C. 

Bunce 10, 4 , M. Fenton 6 , K. Bonstein 10 . 1 Research, 

College of Optometrists, London, United Kingdom; 

2 

Psychology, City University London, London, 

United Kingdom; 3 Cochrane Eyes and Vision 

Group, London School of Hygiene and Tropical 

Medicine, London, United Kingdom; 4 Institute 

of Ophthalmology, University College London, 

London, United Kingdom; 5 Fight for Sight, London, 

United Kingdom; 6 UK Database of Uncertainties 

about the Effects of Treatments (UK DUETs), 

National Institute for Clinical Excellence (NICE), 

London, United Kingdom; 7 The James Lind 

Alliance, National Institute for Health Research 

(NIHR), London, United Kingdom; 8 VISION 2020 

UK, London, United Kingdom; 9 Royal National 

Institute for Blind People (RNIB), London, United 

Kingdom; 10 Biomedical Research Institute at 

Moorfields Eye Hospital NHS Foundation Trust and 

UCL Institute of Ophthalmology, National Institute 

for Health Research, London, United Kingdom *CR 

4391 — D0029 Applying Lean Principles 

to Clinical and Translational Research in 

Ophthalmology. Vesper Williams 1 , P. Summerfelt 1 , 

T. Kaczanowski 1 , K. Packard 1 , D. M. Bishop 1 , M. 

Goldberg 1 , A. Dubra 1, 2 , J. Carroll 1, 3 , A. Suneja 4 . 

1 

Ophthalmology, Medical College of Wisconsin, 

Milwaukee, WI; 2 Biophysics, Medical College 

of Wisconsin, Milwaukee, WI; 3 Cell Biology, 

Neurobiology, and Anatomy, Medical College 

of Wisconsin, Milwaukee, WI; 4 FlowOne Lean 

Consulting, LLC, Milwaukee, WI *CR 

4392 — D0030 Evaluation of Fundamental 

Ophthalmology Knowledge among Internal 

Medicine and Emergency Department Residents. 

Priya Janardhana, M. A. Desai. Boston Medical 

Center, Chestnut Hill, MA 

4393 — D0031 The Ophthalmology Job 

Market In the Aftermath of the Great Recession. 

Chukwuemeka C. Nwanze 1 , R. A. Adelman 3, 1 , 

J. Barth 2, 1 . 1 Lab of Computer Science, MGH, 

Lab of Computer Science, Chestnut Hill, MA; 

2 

Ophthalmology Job Center, American Academy of 

Ophthalmology, SanFrancisco, CA; 3 Department of 

Ophthalmology and Visual Sciences, Yale School of 

Medicine, New Haven, CT 

4394 — D0032 PROSE treatment for moderate 

to severe ocular graft-versus-host disease: 

Analysis of utilization rates versus projected 

demand across four centers. Ryan Ridges, B. 

Beard, D. S. Jacobs. Boston Foundation for Sight, 

Needham, MA *CR 

4395 — D0033 Ophthalmology Consultation on 

Asymptomatic Patients. Ryan K. Wong, J. Huang. 

Ophthalmology and Visual Science, Yale University 

School of Medicine, New Haven, CT 

4396 — D0034 The economic impact of 

cataract surgery in a remote Ghanaian village 

three years after surgical intervention. John 

D. Welling 1 , E. R. Newick 2 , G. C. Tabin 2, 3 . 

1 

Ophthalmology, The Ohio State University 

Havener Eye Institute, Columbus, OH; 2 Himalayan 

Cataract Project, Waterbury, VT; 3 Ophthalmology 

and Visual Sciences, University of Utah John A. 

Moran Eye Center, Salt Lake City, UT 

4397 — D0035 Immediately Sequential 

Bilateral Cataract Surgery-A Cost-effective 

Procedure. Monali Malvankar 1 , W. G. Hodge 1 , R. 

Filek 1 , M. Iqbal 2 , M. A. Shakir 1 , M. Malvankar 1 , S. 

Chavda 1 , F. F. Si 1 . 1 Ophthalmology, The University 

of Western Ontario, London, ON, Canada; 2 Queens 

University, Kingston, ON, Canada 

4398 — D0036 iPhone applications in 

ophthalmology: Current capabilities, limitations 

and future directions. Nicholas M. Cheng 1 , R. 

Chakrabarti 2, 3 , J. K. Kam 3 . 1 The Royal Melbourne 

Hospital, Melbourne, VIC, Australia; 2 Centre for 

Eye Research Australia, Melbourne, VIC, Australia; 

3 

The Royal Victorian Eye and Ear Hospital, 

Melbourne, VIC, Australia 

4399 — D0037 Activity and epidemiology of a 

recently opened ophthalmic emergency center 

in a University Hospital. Francois Ameloot 1, 3 , 

N. Agrinier 2 , F. Tréchot 1 , T. Maalouf 1 , K. Angioi 1 . 

1 

Ophthalmology, University Hospital of Nancy, 

Nancy, France; 2 Epidémiologie et Evaluation 

Cliniques, University Hospital of Nancy, Nancy, 

France; 3 Ophthalmology, CHR Metz, Metz, France 

4400 — D0038 Stability of the Relationship 

Between Self-Reported Vision Impairment and 

Blindness and Medical Care Expenditures Over 

Time. Kevin D. Frick, E. Wehler. Health Policy and 

Management, Johns Hopkins Bloomberg Sch of 

Public Hlth, Baltimore, MD *CR 

4401 — D0039 Glaucoma Treatment: A Closer 

Look at Non-adherence. Sumir Pandit 1 , T. C. 

Chen 2 . 1 Harvard Medical School, Boston, MA; 

2 

Ophthalmology/Glaucoma Service, Mass Eye and 

Ear Infirmary, Boston, MA 

4402 — D0040 Predictive Factors for 

Incomplete Adherence to Glaucoma 

Management amongst Singaporean Chinese. 

Reuben C. Foo 1 , H. Chan 2 , E. L. Lamoureux 3, 4 , R. 

Wong 2 , S. Ho 4 , G. Rees 3 , T. Aung 1, 4 , S. Perera 1, 4 , 

T. Wong 1, 4 . 1 Singapore National Eye Centre, 

Singapore, Singapore; 2 Yong Loo Lin School of 

Medicine, Singapore, Singapore; 3 Centre for Eye 

Research Australia, University of Melbourne, 

Royal Victorian Eye and Ear Hospital, Melbourne, 

VIC, Australia; 4 Singapore Eye Research Institute, 


4403 — D0041 Patient Adherence and 

Persistence with Topical Ocular Hypotensive 

Therapy: a Claims-Based Comparison of 

Bimatoprost 0.01% and Travoprost with sofZia. 

Joanna Campbell 1 , G. F. Schwartz 2, 3 , B. LaBounty 4 , 

J. W. Kowalski 1 , V. D. Patel 1 . 1 GHOSR, Allergan, 

Irvine, CA; 2 Greater Baltimore Medical Center, 

Baltimore, MD; 3 Wilmer Eye Institute, Johns 

Hopkins University, Baltimore, MD; 4 Principled 

Strategies, Inc., Encinitas, CA *CR 

4404 — D0042 Identifying requirements for 

effective glaucoma electronic health records: a 

consensus study. John E. Somner 1 , R. R. Bourne 1 , 

P. Shah 2 , R. Froud 3 . 1 Anglia Ruskin University, 

Vision & Eye Research Unit, Cambridge, United 

Kingdom; 2 National Institute for Health Research 

(NIHR) Biomedical Research Centre (BRC), 

Moorfields Eye Hospital NHS Foundation Trust, 

London, United Kingdom; 3 Centre for Primary Care 

and Public Health, Barts and The London School of 

Medicine and Dentistry, London, United Kingdom 

*CR 

4405 — D0043 Quality of Referral Letters 

to a Tertiary Glaucoma Unit and adherence to 

Glaucoma Guidelines. Jason Cheng, L. Beltran- 

Agullo, G. E. Trope, Y. M. Buys. Ophthalmology & 

Vision Sciences, Toronto Western Hospital, Toronto, 

ON, Canada *CR 

4406 — D0044 The Utility of a Medical Student 

Run Glaucoma Screening Program. Mona A. 

Kaleem, V. C. Lerebours, J. W. Logan, J. Llano, L. 

S. Jones. Department of Ophthalmology, Howard 

University Hospital, Washington, DC 

4407 — D0045 Opportunistic Glaucoma 

Screening in Rural India: Role of Vision Centers. 

Mona Khurana, M. A. KADER, R. Ramakrishnan. 

Glaucoma, Aravind Eye Hospital, Tirunelveli, India 

4408 — D0046 Qualitative Analysis of Web- 

Based LASIK Information Sessions. Roni 

M. Shtein, P. P. Lee. Ophthalmology, Univ of 

Michigan-Kellogg Eye Ctr, Ann Arbor, MI *CR 

4409 — D0047 Results of the Appalachian 

Vision Outreach Program: Year 2. J V. Odom, R. 

Coakley, J. Charlton, S. Morrison. Ophthalmology, 

West Virginia Univ Eye Inst, Morgantown, WV 

4410 — D0048 Are outcomes in primary 

retinal detachment repair related to distance 

away from an academic medical center? Kristen 

Harris Nwanyanwu, L. M. Niziol, D. C. Musch, D. 

N. Zacks. Department of Ophthalmology and Visual 

Sciences, University of Michigan, Ann Arbor, MI 

*CR 

4411 — D0049 Consent For Future Corneal 

Transplantation And Eye Research From AMD 

Patients In An Ophthalmic Clinic. Meidong 

Zhu 1, 2 , J. Chew 1, 3 , P. Georges 2 , C. Petsoglou 1, 2 , A. 

A. Chang 1, 3 . 1 SSI, Ophthalmology & Eye Health, 

Sydney Eye Hospital Campus, University of 

Sydney, Sydney, NSW, Australia; 2 Lions New South 

Wales Eye Bank, NSW Organ and Tissue Donation 

Service, Sydney, NSW, Australia; 3 Sydney Retina 

Clinic & Day Surgery, Sydney, NSW, Australia *CR 

4412 — D0050 Objective and subjective 

severity of affections observed at emergency 

room in ophthalmology. Aurelie Pison 1 , C. 

Mehanna 1, 4 , G. Sawiress 2 , R. Mikou 1 , A. Queant 3, 1 , 

A. P. Brezin 3, 1 , J. Bourges 3, 1 . 1 Department of 

Ophthalmology, Hotel Dieu/Cochin Hospital, 

APHP, Paris, Paris, France; 2 Department of 

informatics, Hotel Dieu/Cochin Hospital, APHP, 

Paris, Paris, France; 3 Paris Descartes School of 

Medicine, Sorbonne Paris Cité University, Paris, 

France; 4 Team 17, INSERM, CIC des Cordeliers, 

Paris, France *CR 


288


4413 — D0051 Acceptance, Attitudes and 

Beliefs Of Singaporean Chinese Towards 

Subconjunctival, Intracameral and Punctal Plug 

Methods of Sustained Glaucoma Drug Delivery 

Systems. Hiok Hong Chan 1, 2 , T. Wong 1, 3 , E. L. 

Lamoureux 3, 4 , S. Perera 1 . 1 Glaucoma, Singapore 

National Eye Centre, Singapore, Singapore; 2 Yong 

Loo Lin School of Medicine, National of University 

of Singapore, Singapore, Singapore; 3 Singapore Eye 

Research Institute, Singapore, Singapore; 4 Centre 

for Eye Research Australia, Melbourne, VIC, 

Australia *CR 

4414 — D0052 Electronic Health Record 

Systems in Ophthalmology: Impact on Operating 

Room Time Requirements for Cataract Surgery. 

Daniel C. Tu 1, 2 , D. S. Sanders 2 , S. Read-Brown 2 , A. 

S. Brown 2 , D. Choi 3 , T. R. Yackel 4, 5 , M. F. Chiang 2, 4 . 

1 

Ophthalmology, Portland Veterans Administration 

Medical Center, Portland, OR; 2 Casey Eye Institute, 

Ophthalmology, Oregon Health & Science 

University, Portland, OR; 3 Public Health and 

Preventive Medicine, Oregon Health & Science 

University, Portland, OR; 4 Medical Informatics, 

Oregon Health & Science University, Portland, OR; 

5 

Clinical Epidemiology, Oregon Health & Science 

University, Portland, OR *CR 

4415 — D0053 Efficiency improvements using 

an ophthalmological Picture Archiving and 

Communication System (PACS) in the diagnostic 

workflow of an eye hospital. Karsten U. Kortuem, 

W. J. Mayer, S. F. Leicht, L. Reznicek, A. Kampik, 

M. Kernt. Ophthalmology, Ludwig-Maximilians- 

University, Munich, Germany *CR 

4416 — D0054 Ambulatory Surgery Center 

(ASC) Utilization by three Ophthalmic Subspecialists: 

1999-2011. Kamyar Vaziri 1 , A. 

A. Moshfeghi 1 , T. Hernandez-Boussard 2 , N. 

Fijalkowski 3 , D. M. Moshfeghi 3 . 1 Ophthalmology, 

Bascom Palmer Eye Institute, University of Miami 

Miller School of Medicine, Miami, FL; 2 Surgery, 

Stanford University School of Medicine, Palo Alto, 

CA; 3 Ophthalmology, Byers Eye Institute, Horngren 

Family Vitreoretinal Center, Stanford University 

School of Medicine, Palo Alto, CA *CR 

4417 — D0055 Comparison of theoretical 

demand for glaucoma eye care by the African- 

American population of cook county to the 

supply of ophthalmologic manpower as a pilot 

study of access to care. Stephen Watson, D. 

Pyatetsky. Ophthalmology, Northwestern University 

Feinberg School of Medicine, Chicago, IL 

4418 — D0056 Trends in Utilization of 

Ancillary Testing for Patients with Exudative 

Macular Degeneration and Macular Edema 

from 2001 to 2009. Eric W. Schneider 1, 2 , P. 

Mruthyunjaya 1 , N. Talwar 2 , K. Harris Nwanyanwu 2 , 

B. Nan 3 , J. D. Stein 2 . 1 Ophthalmology, Duke 

University, Durham, NC; 2 Ophthalmology and 

Visual Sciences, University of Michigan, Ann 

Arbor, MI; 3 Biostatistics, University of Michigan, 

Ann Arbor, MI *CR 

4419 — D0057 Comparing Patient and Public 

Preferences for Health States Associated with 

Age-Related Macular Degeneration. Thomas 

Butt 1 , H. M. Dunbar 1 , S. Morris 2 , S. Orr 3 , G. S. 

Rubin 1, 4 . 1 Institute of Ophthalmology, University 

College London, London, United Kingdom; 

2 

Department of Applied Health Research, 

University College London, London, United 

Kingdom; 3 Department of Civil and Environmental 

Engineering, University College London, London, 

United Kingdom; 4 NIHR Moorfields Biomedical 

Research Centre, London, United Kingdom 

4420 — D0058 Provision of Mass Drug 

Administration for Trachoma Control: Cost per 

gain in coverage. Sheila K. West 1 , H. A. Mkocha 2 , 

B. E. Munoz 1 , K. D. Frick 3 . 1 Ophthalmology, Johns 

Hopkins Wilmer Eye Inst, Baltimore, MD; 2 Kongwa 

Trachoma Project, Kongwa, United Republic of 

Tanzania; 3 Health Services Research Division, 

Johns Hopkins University, Baltimore, MD *CR 

4421 — D0059 Trachoma Control: A Potential 

Field Test for Ocular C. Trachomatis Infection. 

Alexander Jenson 1, 2 , L. Dize 3 , H. A. Mkocha 2, 1 , B. 

E. Munoz 1, 2 , J. S. Lee 1, 2 , S. K. West 1, 2 . 1 Dana Center 

for Preventative Opthamology, The Johns Hopkins 

University, Baltimore, MD; 2 Kongwa Trachoma 

Project, The Johns Hopkins University, Kongwa, 

United Republic of Tanzania; 3 Infectious Disease, 

The Johns Hopkins University, Baltimore, MD 

4422 — D0060 Compliance with Eye Screening 

Guidelines among Newly-Diagnosed Diabetic 

Patients without Diabetic Retinopathy. David 

J. Lee 1 , P. Rosa 2 , W. J. Feuer 2 , B. L. Lam 2 , J. C. 

Schiffman 2 , N. Kumar 1 , A. Morante 2 . 1 Epidemiology 

& Public Health, University of Miami, Miami, FL; 

2 

Bascom Palmer Eye Institute, University of Miami, 

Miami, FL *CR 

4423 — D0061 Methods of Assessing Provider 

Performance for Quality Improvement. Paul 

P. Lee 1 , G. McGwin 2 , S. Asrani 1 , W. Rafferty 1 , 

D. Lobach 1 , K. Kimrey 1 . 1 Ophthalmology and 

Visual Sciences, University of Michigan, Ann 

Arbor, MI; 2 University of Alabama - Birmingham, 

Birmingham, AL *CR, f 

4424 — D0062 Electronic health record 

(EHR) systems in ophthalmology: Impact on 

clinical documentation. David S. Sanders 1 , D. 

Lattin 1 , D. C. Tu 1, 2 , S. Read-Brown 1 , D. J. Wilson 1 , 

T. S. Hwang 1 , J. C. Morrison 1 , T. R. Yackel 3 , M. 

F. Chiang 1, 3 . 1 Ophthalmology, Oregon Health & 

Science University, Portland, OR; 2 Ophthalmology 

Operative Care Division, Portland VA Medical 

Center, Portland, OR; 3 Medical Informatics and 


University, Portland, OR *CR 

4425 — D0063 Ophthalmologists’ Attitudes 

on Implementing an Electronic Health Record 

System. Monica M. Michelotti 1 , J. Weizer 1 , T. S. 

Blachley 1 , K. Zheng 2 , M. Couper 3 , G. Greenberg 4 , 

S. Kileny 5 , G. Branford 6 , D. A. Hanauer 5 . 

1 


Arbor, MI; 2 School of Public Health, University 

of Michigan, Ann Arbor, MI; 3 Institute for Social 

Research, University of Michigan, Ann Arbor, MI; 

4 

Family Medicine, University of Michigan, Ann 

Arbor, MI; 5 Pediatrics, University of Michigan, 

Ann Arbor, MI; 6 Internal Medicine, University of 

Michigan, Ann Arbor, MI 

4426 — D0064 Implementation of electronic 

health record systems in ophthalmology: 

impact on clinical volume compared to other 

medical fields. Travis Redd 1 , S. Read-Brown 1 , A. 

Kitzmiller 1 , T. R. Yackel 2 , D. Choi 3 , M. F. Chiang 2 . 

1 

Ophthalmology, Casey Eye Institute, Oregon 


2 

Ophthalmology & Medical Informatics, Casey 

Eye Institute, Oregon Health & Science University, 

Portland, OR; 3 Public Health & Preventive 

Medicine, Oregon Health & Science University, 

Portland, OR *CR 

4427 — D0065 Physician and patient 

perceptions of electronic health record (EHR) 

use in a tertiary care ophthalmologic clinic. 

Patrick Chan, R. Singh, S. Charvat. Cole Eye 

Institute, Cleveland Clinic, Cleveland, OH *CR 

4428 — D0066 Critical Review of High 

Quality Ophthalmology Educational Web 

Resources Targeting Trainees. Milad Modabber 1 , 

S. Arora 2 , K. F. Damji 3 , F. Adatia 4 . 1 Medicine, 

McMaster University, Hamilton, ON, Canada; 

2 


AB, Canada; 3 Ophthalmology, University of 

Alberta, Edmonton, AB, Canada; 4 Ophthalmology, 

University of Calgary, Edmonton, AB, Canada 




422 Ocular Trauma 

Moderator: Gerald McGwin 

4429 — D0114 Characteristics of eyelid 

laceration due to dog bite in children. Mohammad 

Ali Sadiq 1, 2 , I. Mantagos 1, 2 . 1 Department of 

Ophthalmology, Boston Children’s Hospital, 

Boston, MA; 2 Ophthalmology, Harvard Medical 

School, Boston, MA 

4430 — D0115 Demographic and Clinical 

Profile of Ocular Chemical Injuries in Children. 

Pooja Bandivadekar, H. Shekhar, N. Sharma, R. B. 

Vajpayee. Dr.rajendra prasad Centre, AIIMS, New 

Delhi, India 


8:30 am – 10:15 am 


289



8:30 am – 10:15 am 

4431 — D0116 Motor Vehicle Crash- 

Associated Eye Injuries Presenting to United 

States Emergency Departments. Grayson W. 

Armstrong 1, 2 , A. J. Chen 1, 3 , J. G. Linakis 4, 5 , 

M. J. Mello 2, 5 , P. B. Greenberg 1, 6 . 1 Division of 

Ophthalmology, Warren Alpert Med Sch of Brown 

Univ, Providence, RI; 2 Department of Community 

Health, Warren Alpert Medical School of Brown 

University, Providence, RI; 3 Program in Liberal 

Medical Education, Brown University, Providence, 

RI; 4 Department of Pediatrics, Warren Alpert 

Medical School of Brown University, Providence, 

RI; 5 Department of Emergency Medicine, Warren 

Alpert Medical School of Brown University, 

Providence, RI; 6 Section of Ophthalmology, 

Providence VA Medical Center, Providence, RI 

4432 — D0117 A Ten Year Review of Open 

Globe Trauma in Elderly Patients at an Urban 

Hospital. Iris Y. Sheng, A. M. Bauza, P. D. Langer, 

M. A. Zarbin, N. Bhagat. IOVS, New Jersey 

Medical School, Newark, NJ *CR 

4433 — D0118 Clinical outcomes of surgicallytreated 

trapdoor fractures in the pediatric 

population. Kathleen C. Oktavec, S. L. Merbs, M. 

Grant. Division of Oculoplastics, The Wilmer Eye 

Institute, Baltimore, MD *CR 

4434 — D0119 Severe Ocular Trauma In The 

Emergency Room. Albert Lin, C. Confait, S. T. 

Hoadley, M. Ahmad, C. J. Chen. Ophthalmology, 

Univ of Mississippi Med Center, Jackson, MS 

4435 — D0120 Outcomes and characteristics 

of open-globe injuries with delayed presentation. 

Danielle Trief 1, 2 , M. T. Andreoli 3 , A. S. Shah 1, 2 , Y. 

Yonekawa 1, 2 , C. M. Andreoli 1, 4 . 1 Ophthalmology, 

Mass Eye and Ear Infirmary, Boston, MA; 

2 

Ophthalmology, Boston Children’s Hospital, 

Boston, MA; 3 Ophthalmology, University of 

Illinois College of Medicine at Chicago, Chicago, 

IL; 4 Ophthalmology, Harvard Vanguard Medical 

Associates, Boston, MA 

4436 — D0121 Correlation of Ocular Trauma 

Score and visual acuity outcomes in combatrelated 

traumatic cataracts. Michael P. Smith, M. 

Colyer, D. L. Greenburg. Ophthalmology, Walter 

Reed Nt’l Military Med Ctr, Bethesda, MD 

4437 — D0122 Ocular and adnexal injuries in 

patients with all-terrain vehicle accidents in West 

Virginia. Evan Newbolt, C. B. Chen, J. Nguyen, J. 

Sivak-Callcott, B. D. Ellis, C. M. Bingham. West 

Virginia University, Morgantown, WV 

4438 — D0123 Characteristics and 

Management of Traumatic Eyes with Full 

Thickness Corneal Lacerations. Yi C. Lai, A. 

M. Bauza, P. D. Langer, S. Guo, D. S. Chu, A. S. 

Khouri, R. D. Fechtner, R. E. Turbin, N. Bhagat. 

Institute of Ophthalmology and Visual Science, 

New Jersey Medical School, Newark, NJ *CR 

4439 — D0124 Nail Gun-Induced Open Globe 

Injuries: A Ten-Year Retrospective Review. 

Avni Shah, A. M. Bauza, A. M. Kolomeyer, P. 

D. Langer, M. A. Zarbin, N. Bhagat. Institute of 

Ophthalmology and Visual Science, UMDNJ New 

Jersey Medical School, Newark, NJ *CR 

4440 — D0125 Utilizing HIWA, a Scoring 

System of Pediatric Ocular Trauma 

Retrospective Reports, Analyzing Existing 

Literature and Informing Future Standards. 

Andrea Honda 1 , P. Latkany 1 , M. Lorenzo 1 , E. Su 2 . 

1 

New York Eye and Ear Infirmary, New York, NY; 

2 

St. Luke’s Roosevelt Hospital, New York, NY 

4441 — D0126 Enucleation following Open 

Globe Injury. Ananya Anne, A. M. Bauza, P. D. 

Langer, R. E. Turbin, M. A. Zarbin, N. Bhagat. 

University of Medicine and Dentistry of New 

Jersey, Newark, NJ *CR 



Glaucoma 

423 Ocular Blood Flow; Surgery and 

Wound Healing 

Moderators: Leopold Schmetterer and Alon Harris 

4442 — D0182 Retinal Nerve Fiber Layer 

Thickness is Correlated to Retrobulbar Blood 

Flow in Glaucoma Patients of African Descent. 

Anne Schroeder 1 , A. Harris 1 , B. A. Siesky 1 , L. 

A. Tobe1, N. J. Kim1, A. Amireskandari 1 , B. M. 

Marek 1 , L. Racette 1 , G. J. Eckert 2 , A. Tyring 1 . 

1 

Ophthalmology, Indiana University School 

of Medicine, Indianapolis, IN; 2 Division of 

Biostatistics, Indiana University School of 

Medicine, Indianapolis, IN *CR 

4443 — D0183 Changes in Retinal Blood Flow 

are Strongly Correlated to Changes in Optic 

Nerve Head Morphology in Patients of African 

Descent. Leslie A. Tobe 1 , A. Harris 1 , B. A. Siesky 1 , 

L. Racette 1 , D. WuDunn 1 , A. Amireskandari 1 , 

N. J. Kim 1 , A. H. Huck 1 , A. Tyring 1 , M. Zalish 2 . 

1 

Ophthalmology, Indiana University School of 

Medicine, Indianapolis, IN; 2 Ophthalmology, 

Kaplan Medical Center, Rehovot, Israel *CR 

4444 — D0184 Comparison of Nebulized 

dorzolamide/timolol fixed combination 

Mist vs Drops on Retrobulbar Blood Flow, 

Intraocular Pressure in Glaucoma Patients. 

Ruta Barsauskaite 1 , A. Harris 2 , I. Januleviciene 1 , 

L. Siaudvytyte 1 , V. Diliene 1 , B. Siesky 2 . 1 Eye 

Clinic, Lithuanian University of Health Sciences, 

Kaunas, Lithuania; 2 Eugene and Marilyn Glick Eye 

Institute, Indiana University School of Medicine, 

Indianapolis, IN *CR, f 

4445 — D0185 Ocular Hemodynamic Changes 

after Trabeculectomy in Pseudoexfoliative and 

Primary Open-Angle Glaucoma. Vaida Diliene 1 , 

A. Harris 2 , I. Januleviciene 1 , L. Siaudvytyte 1 , R. 

Barsauskaite 1 , B. Siesky 2 . 1 Eye Clinic, Lithuanian 

University of Health ASciences, Kaunas, Lithuania; 

2 

Eugene and Marilyn Glick Eye Institute, Indiana 

University School of Medicine, Indianapolis, IN 

*CR, f 

4446 — D0186 Systemic Blood Pressure and 

Ocular Perfusion Pressure Affect Macular 

Thickness in Glaucoma Patients of African 

Descent. Brian M. Marek 1 , A. Harris 1 , B. A. Siesky 1 , 

L. A. Tobe 1 , A. Tyring 1 , A. Amireskandari 1 , N. J. 

Kim 1 , J. G. Paschall 1 , G. J. Eckert 2 , L. Racette 1 . 

1 

Ophthalmology, Indiana Univ. Sch. of Medicine, 

Indianapolis, IN; 2 Division of Biostatistics, Indiana 

Univ. Sch. of Medicine, Indianapolis, IN *CR 

4447 — D0187 Retinal and Macular 

Morphology is Correlated with Retrobulbar 

Vascular Resistance in Diabetic Patients with 

Glaucoma. Austin L. Gerber 1 , A. Harris 1 , B. A. 

Siesky 1 , G. J. Eckert 3 , I. Januleviciene 2 , N. J. Kim 1 , 

A. Amireskandari 1 , B. M. Marek 1 , L. A. Tobe 1 , A. 

H. Huck 1 . 1 Ophthalmology, Indiana Univ School 

of Med, Indianapolis, IN; 2 Eye Clinic, Lithuanian 

University of Health Sciences, Kaunas, Lithuania; 

3 

Division of Biostatistics, Indiana Univ School of 

Med, Indianapolis, IN *CR 

4448 — D0188 Blood pressure induced 

dynamic blood flow autoregulation in the optic 

nerve head of early experimental glaucoma. Lin 

Wang, C. Piper, G. Cull, C. F. Burgoyne. Devers 

Eye Institute, Legacy Research Institute, Portland, 

OR *CR 

4449 — D0189 The NO donor, isorbide-5- 

mononitrate alone or combined with timolol, 

latanoprost or dorzolamide ameliorates 

intraocular pressure and ocular hemodynamic in 

an experimental model of glaucoma in rabbits. 

Francesco Impagnatiello 1 , B. Giambene 2 , F. 

Fabrizi 3 , E. Bastia 1 , F. Galassi 2 , E. Masini 3 . 1 Nicox 

Research Institute, Bresso, Milan, Italy; 2 Eye Clinic, 

University of Florence, Florence, Italy; 3 Preclinical 

and Clinical Pharmacology, University of Florence, 

Florence, Italy *CR 

4450 — D0190 Effects of diverse Nitric 

Oxide donation on ocular hemodynamic and 

intraocular pressure in normotensive rabbits. 

Elena Bastia 1 , F. Impagnatiello 1 , D. Miglietta 1 , 

B. Giambene 2 , E. Masini 3 , N. Almirante 1 . 1 Nicox 

Research Institute, Bresso, Milan, Italy; 2 Eye Clinic, 

University of Florence, Florence, Italy; 3 Preclinical 

and Clinical Pharmacology, University of Florence, 

Florence, Italy *CR 

4451 — D0191 Association between waveform 

changes in optic nerve head circulation and 

retinal nerve fiber layer thickness in normaltension 

glaucoma patients compared to healthy 

subjects, measured by laser speckle flowgraphy. 

Yukihiro Shiga, Y. Yokoyama, T. Asano, S. Maekawa, 

S. Tsuda, N. Aizawa, K. Omodaka, M. Ryu, T. 

Nakazawa. Ophthalmology, Tohoku University, 

Sendai, Japan *CR 

4452 — D0192 Analysis of the Correlation 

Between Peripapillary Choroidal Thickness 

and the Nerve Fiber Layer Damage in Primary 

Open Angle Glaucoma Patients. Nimesh Patel 1 , C. 

Krishnan 2, 1 . 1 Tufts University School of Medicine, 

Boston, MA; 2 New England Eye Care Center, 



290


4453 — D0193 Change in intraocular pressure 

is a major determinant of retinal vein pulsation 

properties. William Morgan 1 , M. Hazelton 2 , B. 

Betz-Stablein 2 , P. House 1 , Y. Dao-Yi 1 . 1 Lions Eye 

Institute, Nedlands, WA, Australia; 2 Institute 

of Fundamental Sciences, Massey University, 

Palmerston North, New Zealand *CR, f 

4454 — D0194 Nonphysiologic nocturnal 

blood pressure dipping in Primary Open Angle 

Glaucoma (POAG) and Normal Pressure 

Glaucoma (NPG) patients. Karin R. Pillunat, C. 

Hermann, O. Furashova, E. Spoerl, L. E. Pillunat. 

Dept of Ophthalmology, Univ Clinic Carl Gustav 

Carus Dresden, Dresden, Germany f 

4455 — D0195 Relation of Spontaneous Retinal 

Venous Pulsation and Disc Hemorrhage in 

Open Angle Glaucoma. Mijin Kim 1, 2 , T. Kim 1, 2 , 

R. N. Weinreb 3 , E. Lee 1, 2 , J. Seo 4 , K. Park 1 , D. 

Kim 1 . 1 Ophthalmology, Seoul National University 

Bundang Hospital, Seongnam, Gyeonggi-do, 

Republic of Korea; 2 Ophthalmology, Seoul National 

University College of Medicine, Seoul, Republic of 

Korea; 3 Hamilton Glaucoma Center and Department 

of Ophthalmology, University of California San 

Diego, La Jolla, CA; 4 Pusan National University 

Yangsan Hospital, Yangsan, Republic of Korea *CR 

4456 — D0196 Optic Nerve Capillaries Blood 

Oxygenation in Normal and Primary Open- 

Angle Glaucoma Subjects. Vasile Diaconu, V. 

Tran. Ecole D’optometrie, University of Montreal, 

Montreal, QC, Canada 

4457 — D0197 Reduced Retinal Blood Flow 

is Associated with Thinner Retinal Nerve 

Fiber Layer in Glaucomatous Eyes with Single 

Hemifield Damage. Mitra Sehi 1 , I. Goharian 1 , R. 

Konduru 2 , O. Tan 3 , S. Srinivas 2 , S. R. Sadda 2 , D. 

Huang 3 , D. S. Greenfield 1 . 1 Ophthalmology, Bascom 

Palmer Eye Institute, University of Miami, Palm 

Beach Gardens, FL; 2 Ophthalmology, Doheny Eye 

Institute, University of Southern California, Los 

Angeles, CA; 3 Ophthalmology, Casey Eye Institute, 

Oregon Health and Science University, Portland, 

OR *CR, f 

4458 — D0198 Optic Nerve Head Label-free 

Microangiography: OCT-based Correlation 

of Microstructure and Microvasculature in 

Normal & Open Angle Glaucoma Subjects. 

Lin An 1 , P. Li 1 , M. A. Johnstone 2 , R. K. Wang 1, 2 . 

1 

Bioengineering, University of Washington, Seattle, 

WA; 2 Ophthalmology, University of Washington, 

Seattle, WA *CR 

4459 — D0199 Effect of Cerebrospinal 

Fluid Pressure on Central Retinal Artery 

Hemodynamics: a Mathematical Model. Lucia 

Carichino 1 , G. Guidoboni 1 , A. Amireskandari 2 , 

B. Siesky 2 , A. Harris 2 . 1 Mathematics, Indiana 

University Purdue Univ, Indianapolis, IN; 

2 

Ophthalmology, Indiana University Sch of 


4460 — D0200 The effect of anthocyanins 

and ginko biloba extract treatment in patients 

with open-angle glaucoma depending on 

the presence of diabetes mellitus. Yong Woo 

Lee 1 , S. Shim 1 , J. Kim 1 , C. Choi 1 , K. Park 2 . 

1 

Ophthalmology, Sungkyunkwan University School 

of Medicine,Kangbuk Samsung Hospital, Seoul, 


University College of Medicine, Seoul, Republic 

of Korea 

4461 — D0201 A theoretical investigation of 

the relationship between intraocular pressure, 

cerebrospinal fluid pressure, arterial blood 

pressure, blood flow autoregulation and retinal 

hemodynamics. Giovanna Guidoboni 1 , A. Harris 2 , 

S. Cassani 1 , L. Carichino 1 , A. Amireskandari 2 , B. A. 

Siesky 2 . 1 Mathematics, Indiana University Purdue 

Univ, Indianapolis, IN; 2 Ophthalmology, Indiana 


*CR 

4462 — D0202 Effect of Trabeculectomy on 

Retinal Hemodynamics: Mathematical Modeling 

of Clinical Data. Simone Cassani 1 , G. Guidoboni 1 , 

I. Januleviciene 3 , L. Carichino 1 , B. Siesky 2 , L. A. 

Tobe 2 , A. Amireskandari 2 , A. Harris 2 . 1 Mathematics, 

Indiana University Purdue Univ, Indianapolis, 

IN; 2 Ophthalmology, Indiana University Sch 

of Medicine, Indianapolis, IN; 3 Eye Clinic Of 

Lithuanian University of Health Sciences, Kaunas, 

Lithuania *CR 

4463 — D0203 Effect of intraocular pressure 

and arterial blood pressure on oxygen saturation 

levels in the retina: a theoretical model. Julia 

Arciero 1 , A. Harris 2 , G. Guidoboni 1 . 1 Mathematics, 

Indiana Univ-Purdue Univ Indianapolis, 

Indianapolis, IN; 2 Ophthalmology, Indiana 

University, Indianapolis, IN *CR 

4464 — D0204 Retinal Oximetry in Early 

Primary Open Angle Glaucoma. Scott D. 

Lawrence, P. D. Jani, K. Billow, J. Mwanza, I. 

A. Falkenstein. Ophthalmology, Univ of North 

Carolina at Chapel Hill, Chapel Hill, NC 

4465 — D0205 Optic nerve head basal blood 

flow increases early and then progressively 

decreases in non-human primate experimental 

glaucoma. Grant Cull, C. Piper, C. F. Burgoyne, 

L. Wang. Devers Eye Institute, Legacy Research 

Institute, Portland, OR *CR 

4466 — D0206 Correlation between 

papillomacular bundle thickness (PMBT) 

and optic nerve blood flow in primary openangle, 

including normal-pressure, glaucoma. 

Wataru Kobayashi 1 , K. Omodaka 1 , K. Togashi 2 , M. 

Ryu 1 , T. Yuasa 2 , T. Nakazawa 1 . 1 Ophthalmology, 

Tohoku University, Sendai, Japan; 2 Bio-Systems 

Engineering, Yamagata University, Yonezawa, 

Japan *CR 

4467 — D0207 Optic Nerve Head Morphology 

and Retrobulbar Blood Flow; Differences 

between Glaucoma Patients with and without 

Diabetes. Joshua G. Paschall, A. Harris, B. A. 

Siesky, L. A. Tobe, A. Amireskandari, N. J. Kim, 

C. R. Yung, B. M. Marek, D. WuDunn, J. Abrams. 



4468 — D0208 Glaucoma Patients with 

Diabetes Have Increasing Vascular Resistance 

in the Ophthalmic and Central Retinal Arteries 

Compared to Glaucoma Patients without 

Diabetes. Nathaniel J. Kim, A. Harris, B. A. Siesky, 

A. Amireskandari, J. G. Paschall, D. WuDunn, 

L. B. Cantor, C. R. Yung, L. A. Tobe, J. Abrams. 



4469 — D0209 Changes in Retinal Blood Flow 

Correlate More Strongly with Changes in Optic 

Nerve Head Morphology in Glaucoma Patients 

with Diabetes Compared to Glaucoma Patients 

without Diabetes. Annahita Amireskandari, A. 

Harris, B. A. Siesky, N. J. Kim, B. M. Marek, J. 

G. Paschall, L. B. Cantor, Y. P. Catoira-Boyle, J. 

Abrams, L. A. Tobe. Ophthalmology, Indiana Univ 

Sch of Medicine, Northville, MI *CR 


Ocular Perfusion Pressure affect Retrobulbar 

Blood Flow Differently in Glaucoma Patients 

of European and African Descent. Ariel Tyring, 

A. Harris, B. A. Siesky, L. Racette, Y. P. Catoira- 

Boyle, A. Amireskandari, N. J. Kim, J. G. Paschall, 

B. M. Marek, L. A. Tobe. Ophthalmology, Indiana 


*CR 

4471 — D0211 Retinal Oximetry in Primary 

Open-Angle Glaucoma: Differences in Patients 

of African and European Descent. Brent A. 

Siesky, A. Harris, L. Racette, L. B. Cantor, L. A. 

Tobe, Y. P. Catoira-Boyle, C. R. Yung, D. WuDunn, 

J. M. Beach. Ophthalmology, Indiana Univ Sch of 

Medicine, Zionsville, IN *CR 


Ocular Perfusion Pressure Affects Blood Flow 

to the Optic Nerve Head in Glaucoma Patients 

with Diabetes. Andrew H. Huck 1 , A. Harris 1 , B. A. 

Siesky 1 , L. A. Tobe 1 , N. J. Kim 1 , A. Amireskandari 1 , 

B. M. Marek 1 , I. Januleviciene 2 , B. M. Wirostko 3 , 

G. J. Eckert 4 . 1 Ophthalmology, Indiana 

University School of Medicine, Indianapolis, IN; 

2 

Ophthalmology, Lithuanian University of Health 

Sciences, Kaunas, Lithuania; 3 Ophthalmology, 

University of Utah, Park City, UT; 4 Division 

of Biostatistics, Indiana University School of 


4473 — D0213 Effects of Rho Kinase 

Inhibitor on mRNAs Associated with Glaucoma 

Progression in Human Trabecular Meshwork 

Cells Following Oxidative Stress. Hideki 

Mochizuki, J. Hirata, Y. Kiuchi. Ophthalmology and 

Visual Science, Hiroshima University, Hiroshima, 

Japan 

4474 — D0214 Burden of care associated with 

Childhood Glaucoma: 4 year study. Jacey Hanna, 

L. Ravindraraj, R. D. Fechtner, A. S. Khouri. 

Ophthalmology, The Institute of Ophthalmology 

and Visual Science, New Jersey Medical School, 

Newark, NJ 


8:30 am – 10:15 am 


291



8:30 am – 10:15 am 

4475 — D0215 Evaluation of surface free 

energy of Aurolab Aqueous Drainage Implant 

(AADI) and its influence on cell adhesion 

property, in comparison with Baerveldt Implant. 

Chidambaranathan Gowri Priya 1 , K. Sivakumar 2 , 

M. Pillai 3 , S. Krishnadas 4 , R. D. Sriram 5 , V. 

Muthukkaruppan 6 . 1 Department of Immunology 

and Stem Cell Biology, Aravind Medical Research 

Foundation, Dr. G. Venkataswamy Eye Research 

Institute, Madurai, India; 2 Polymer Division, 

Aurolab, Madurai, India; 3 Glaucoma Clinic, 

Aravind Eye Hospital and Postgraduate Institute of 

Ophthalmology, Madurai, India; 4 Glaucoma Clinic, 

Aravind Eye Hospital and Postgraduate Institute of 

Ophthalmology, Madurai, India; 5 Aurolab, Madurai, 

India; 6 Department of Immunology and Stem Cell 

Biology, Aravind Medical Research Foundation, Dr. 

G. Venkataswamy Eye Research Institute, Madurai, 

India *CR 

4476 — D0216 Targeting specific TGF-β 

signaling pathways to prevent bleb fibrosis after 

glaucoma drainage device surgery. Christian 

K. Vorwerk 1 , V. Sokalskis 2 , A. Zabelyshenskiy 2 , H. 

Thieme 1 , L. Choritz 1, 2 . 1 Dept of Ophthalmology, 

Otto von Guericke University, Magdeburg, 

Germany; 2 Dept of Ophthalmology, University 

Medical Center, Mainz, Germany 

4477 — D0217 Retrospective study of 

congenital glaucoma surgical treatment. Hector 

Bello Lopez Portillo, J. Jimenez-Roman, M. Turati- 

Acosta, M. García-Huerta, R. Castañeda Diez, F. 

Gil Carrasco, C. Isida Llerandi. Asociacion para 

Evitar la Ceguera en Mexico, Mexico, Mexico 

4478 — D0218 Intraocular Pressure Reduction 

of Modified 360-degree Suture Trabeculotomy 

in Intent-to-treat Eyes. Daisuke Shiba, T. Ono, N. 

Ozeki, K. Yuki, K. Tsubota. Ophthalmology, Keio 

University, Shinjuku-ku, Japan *CR 

4479 — D0219 Evaluation of Dose Effect 

of ALK-5 Inhibitor and Controlled Delivery 

with Novel Pentablock Polymer in Glaucoma 

Filtration Surgery. Hiroshi Nakamura 1, 2 , J. J. 

Dunmire 1 , V. Sutariya 2, 3 , M. Hewit 2 , D. Wehrung 2 , 

S. Patel 4 , A. K. Mitra 4 . 1 Ophthalmology, Summa 

Health System, Akron, OH; 2 Pharmaceutical 

sciences, Northeast Ohio Medical University, 

Rootstown, OH; 3 Pharmaceutical sciences, 

University of South Florida, Tampa, FL; 

4 

Pharmaceutical sciences, University of Missouri- 

Kansas City, Kansas City, MO 

4480 — D0220 The effect of steroid and matrix 

metalloproteinase inhibitor on bleb survival 

in an experimental animal model. Alastair 

Lockwood 1, 2 , A. Mohamed Ahmed 1, 2 , A. Khalili 1, 2 , 

S. Awwad 1, 2 , G. Sharma 1, 2 , S. Brocchini 1, 2 , P. T. 

Khaw 1 . 1 NIHR Moorfields Biomedical Research 

Centre, London, United Kingdom; 2 UCL School 

of Pharmacy, University College London, London, 


4481 — D0221 Attenuation of Glaucoma 

Filtration Surgery-induced Scarring by an 

FDA-approved Histone Deacetylase Inhibitor, 

Suberoylanilide Hydroxamic Acid (SAHA). Ajay 

Sharma, J. W. Brubaker, M. Reyes, J. T. Rodier, 

A. Tandon, R. R. Mohan. Mason Eye Institute, 

University of Missouri, Columbia, MO 

4482 — D0222 Surgical Outcomes of 

Augmented MMC Trabeculectomy After 

Failed Seton Surgery. Jose A. Paczka 1, 3 , L. A. 

Giorgi-Sandoval 2, 3 , M. A. Ramos-Hernandez 1 , J. 

Jimenez-Roman 2, 3 , A. Merikansky 2 . 1 Oftalmologia, 

University of Guadalajara, Guadalajara, Mexico; 

2 

Oftalmologia, Asistencia e Investigacion en 

Glaucoma, A.C., Guadalajara, Mexico; 3 Glaucoma, 

Global Glaucoma Institute, Guadalajara, Mexico 

4483 — D0223 Influence of endothelin-1 in 

aqueous humor on IOP and filtration surgery 

outcome. Lars Choritz 1, 2 , B. Mahmoodi 1 , M. 

Machert 1 , N. Pfeiffer 1 , H. Thieme 2 . 1 Ophthalmology, 

University Medical Center, Mainz, Germany; 

2 

Ophthalmology, University Clinic, Otto von 

Guericke University, Magdeburg, Germany *CR 

4484 — D0224 A New Technique for Glaucoma 

Surgery: Scorolli Trabeculectomy. Lucia 

Scorolli 1 , E. Meduri 2 , A. De Leo 5 , R. Meduri 3 , E. 

Zere 4 , P. Piccaluga 5 , S. Scalinci 1 . 1 Ophthalmology, S 

Orsola Malpighi Hospital Bologna, Bologna, Italy; 

2 

Medical School, University of Sophia, Sophia, 

Bulgaria; 3 IE Business School, Madrid, Spain; 

4 

Ophthalmology, Univesity La Sapienza, Rome, 

Italy; 5 Molecular Pahology, University of Bologna, 

Bologna, Italy 

4485 — D0225 Functional and anatomic 

outcomes following endocyclophotocoagulation 

(ECP) surgery for neo-vascular glaucoma as 

compared to routine glaucoma care. Kyle V. 

Marra 1 , S. Wagley 2 , A. F. Omar 3 , J. G. Arroyo 1 . 

1 

Beth Israel Deaconess Medical Center, Boston, 

MA; 2 College of Human Medicine - Michigan 

State University, East Lansing, MI; 3 Joslin Diabetes 

Center, Boston, MA 

4486 — D0226 Efficacy of Catheter Assisted 

360° Trabeculotomy in Primary Congenital 

Glaucoma (PCG). Erika Wandel 1 , D. Dave 1 , M. 

Vora 2 , C. H. Marcus 3 , R. F. Rothman 3 , T. Frempong 1 , 

D. D. Hayes 3 , A. Angelilli 3 , J. B. Serle 1, 3 . 

1 

Ophthalmology, Mount Sinai Hospital, New York, 

NY; 2 Ophthalmology, North Shore-Long Island 

Jewish Health System, Manhasset, NY; 3 Glaucoma 

Consultants of Long Island, Bethpage, NY *CR 

4487 — D0227 Ahmed glaucoma valve FP7 

and FP8 in pediatric glaucoma: A randomized 

clinical trial. Bruno L. Esporcatte, C. F. Netto, 

T. Tanno, L. S. Melo, I. M. Tavares, C. Rolim de 

Moura. Glaucoma, Federal University of São Paulo, 

São Paulo, Brazil f 

4488 — D0228 A model to measure surgical 

outflow using a two-tubed experimental 

glaucoma drainage device. Craig Ross, D. 

Nguyen, S. S. Pandav, Y. Li, J. G. Crowston, M. 

A. Coote. Centre for Eye Research Australia, 

University of Melbourne, Royal Victorian Eye and 

Ear Hospital, East Melbourne, VIC, Australia 

4489 — D0229 Comparison of Early Post- 

Operative Challenges in P200 Ex-PRESS Shunts 

and Conventional Trabeculectomies. Maheen 

Haque, B. A. Hughes, J. Tannir, R. Momi, C. Kim. 

Kresge Eye Institute/Wayne State University, 

Detroit, MI 

4490 — D0230 Comparision of surgical 

outcomes of Express Shunt and Ahmed Valve 

in Neovascular Glaucoma. Huseyin Kadikoy, B. 

A. Hughes, J. Tannir, R. Momi. Ophthalmology, 

Kresge Eye Institute, Royal Oak, MI 

4491 — D0231 A Novel Minimally Invasive 

Drainage Implant (the MIDI-Arrow): One-Two 

Year Follow Up. Paul F. Palmberg 1 , J. F. Batlle 3 , 

R. Alburquerque 3 , A. Corona-Peralta 3 , I. Riss 4 , 

R. Parrish 1 , E. Arrieta 2 , J. A. Parel 2 . 1 Biophysics 

(Ophthalmology), University of Miami, Miami, 

FL; 2 Ophthalmology, University of Miami, Miami, 

FL; 3 Centro Laser, Santo Domingo, Dominican 

Republic; 4 Pole Ophtalmologogique, Clinique 

Mutualiste, Pessac, France *CR, f 

4492 — D0232 Surgical Outcomes in First 

25 Canaloplasties and Impact of Growing 

Experience on Complications. Elisabeth P. 

Aponte, J. Eisengart. Ophthalmology, Cleveland 

Clinic Cole Eye Institute, Cleveland, OH 

4493 — D0233 Review of the Success Rate 

of an Intraoperative Modified Bleb Revision 

Technique. Priya Gupta, K. S. Arora, C. Lee, D. 

S. Friedman. Wilmer Eye Institute, Johns Hopkins 

Hospital, Baltimore, MD *CR 

4494 — D0234 Clinical and Tomographic 

Findings in Filtering Blebs Undergoing Digital 

Compression. Miriam A. Ramos-Hernandez 2 , 

M. A. Ramos-Hernandez 2 , E. Chavez 2 , L. A. 

Giorgi-Sandoval 1 , J. A. Paczka 1, 2 . 1 Asistencia e 

Investigacion en Glaucoma, A.C., Guadalajara, 

Mexico; 2 Instituto de Oftalmologia y Ciencias 

Visuales, Guadalajara, Mexico 

4495 — D0235 Cyclodialysis incidence in 

anterior segment surgery in an Ophthalmology 

Referral Center. Rodrigo Bolanos 1 , A. Navas 3 , E. 

O. Graue-Hernández 3 , A. J. Ramirez-Miranda 3 , 

J. Ledesma Gil 2 . 1 Research Unit, Inst of Ophthal 

Conde de Valenciana, Mexico City, Mexico; 

2 

Glaucoma, Instituto de Oftalmologia Conde de 

Valenciana, Mexico DF, Mexico; 3 Cornea An 

Refractive Surgery, Instituto de Oftalmologia 

Conde de Valenciana, Mexico DF, Mexico *CR 

4496 — D0236 Optimal administration route 

of bevacizumab after glaucoma filtration 

surgery. Karolien P. Hollanders 1 , T. Van Bergen 1 , 

D. Sijnave 1 , S. Van de Velde 1 , E. Vandewalle 1 , L. 

K. Moons 2 , I. Stalmans 1 . 1 Neuroscience, Lab of 

Ophthalmology, KULeuven, Leuven, Belgium; 

2 

Biology, KULeuven, Leuven, Belgium *CR 


292


6B 

Wednesday, May 08, 2013 11:00 AM-12:45 PM 

Glaucoma 

424 Genetics I 

Moderators: John H. Fingert and 

Andrew J. Lotery 

4497 — 11:00 Genome-wide Association Study 

and Meta-Analysis of Intraocular Pressure in 

Primary Open-Angle Glaucoma Cases and 

Controls in the NEIGHBOR, GLAUGEN and 

AMD-MMAP Studies. Sayoko E. Moroi 1 , A. B. 

Ozel 2 , D. M. Reed 1 , K. E. Branham 1 , M. A. Hauser 3 , 

L. R. Pasquale 4 , J. L. Wiggs 4 , J. E. Richards 1 , J. Z. 

Li 2 . 1 Ophthalmology & Visual Sciences, Univ of 

Michigan-Kellogg Eye Ctr, Ann Arbor, MI; 2 Human 

Genetics, University of Michigan, Ann Arbor, MI; 

3 

Center for Human Genetics, Duke University 

School of Medicine, Durham, NC; 4 Department 

of Ophthalmology, Harvard Medical School, 

Massachusetts Eye and Ear Infirmary, Boston, MA 

*CR 

4498 — 11:15 Molecular mechanisms in 

Primary Glaucoma: POAG-associated variant 

disrupts microRNA regulation of CDKN2B 

expression. Terry Gaasterland 1, 2 , A. N. Dubinsky 3 , 

A. R. La Spada 3, 8 , K. Mansouri 4, 10 , K. H. Willert 8, 9 , 

D. E. Gaasterland 5 , M. A. Hauser 6 , L. R. Pasquale 7 , 

J. L. Wiggs 7 , R. N. Weinreb 10 . 1 Institute for Genomic 

Medicine, Univ of California San Diego, La Jolla, 

CA; 2 Marine Biology Research Division, Univ of 

California San Diego, La Jolla, CA; 3 Department of 

Pediatrics, Univ of California San Diego, La Jolla, 

CA; 4 University of Geneva, Geneva, Switzerland; 

5 

Ophthalmology, Potomac, MD; 6 Department 

of Medicine, Duke University, Durham, NC; 

7 

Massachusetts Eye and Ear Institute, Harvard, 

Cambridge, MA; 8 Cellular and Molecular Medicine; 

Neurosciences, Univ of California San Diego, La 

Jolla, CA; 9 Sanford Consortium for Regenerative 

Medicine, La Jolla, CA; 10 Hamilton Glaucoma 

Center, Univ of California San Diego, La Jolla, CA 

*CR 

4499 — 11:30 Runs of Homozygosity Across 

the Whole Genome Suggests two Novel Genes 

in Primary Congenital Glaucoma. Subhabrata 

Chakrabarti 1 , S. Ganguly 3 , M. Kabra 1 , A. K. 

Mandal 2 , S. Senthil 1 , I. Kaur 1 , P. P. Majumder 4, 3 . 

1 

Brien Holden Eye Research Centre, LV Prasad Eye 

Institute, Hyderabad, India; 2 Jasti V Ramanamma 

Childrens Eye Care Centre, L V Prasad Eye 

Institute, Hyderabad, India; 3 Department of Human 

Genetics, Indian Statistical Institute, Kolkata, 

India; 4 National Institute of Biomedical Genomics, 

Kalyani, India 

4500 — 11:45 Genetic factors and pathways 

affecting retinal nerve fiber layer thickness. 

Cristina Venturini 1, 2 , P. G. Hysi 2 , A. Nag 2 , E. 

Yonova 2 , J. Wang 3, 4 , T. Y. Wong 5, 6 , P. R. Healey 4 , 

P. Mitchell 4 , C. J. Hammond 2 , A. C. Viswanathan 7, 

8 

. 1 Genetics, UCL, Institute of Ophthalmology, 

London, United Kingdom; 2 Twin Research & 

Epidemiology Research, King’s College London, 

London, United Kingdom; 3 Centre for Eye Research 

Australia (CERA), Department of Ophthalmology, 

University of Melbourne, Melbourne, NSW, 

Australia; 4 Department of Ophthalmology, 

University of Sydney Centre for Vision Research, 

Sydney, NSW, Australia; 5 Epidemiology and 

Public Health, National University of Singapore, 

Singapore, Singapore; 6 Singapore Eye Research 

Institute, Singapore, Singapore; 7 Glaucoma Service, 

Moorfield Eye Hospital, London, United Kingdom; 

8 

NIHR Biomedical Research Centre, Moorfield 

Eye Hospital and UCL Institute of Ophthalmology, 

London, United Kingdom *CR 

4501 — 12:00 The role of SIX6 in primary 

open-angle glaucoma. Michael A. Hauser 1, 2 , M. 

Ulmer 1 , Y. Liu 3 , E. Davis 3 , N. Katsanis 3 , Y. Liu 1 , 

L. R. Pasquale 4 , J. L. Wiggs 4 , A. E. Ashley-Koch 1 , 

R. Allingham 2 . 1 Medicine, Duke Univ Medical 

Center, Durham, NC; 2 Ophthalmology, Duke Univ 

Medical Center, Durham, NC; 3 Cell Biology, Duke 

University, Durham, NC; 4 Ophthalmology, Harvard 

Medical School, Boston, MA *CR 

4502 — 12:15 A genome-wide association 

study of intra-ocular pressure identifies a 

novel association in the gene FAM125B in the 

TwinsUK cohort. Abhishek Nag 1 , P. G. Hysi 1 , 

C. Venturini 2, 1 , E. Yonova 1 , K. M. Williams 1 , C. 

J. Hammond 1 . 1 Department of Twin Research, 

King’s College London, London, United Kingdom; 

2 

Institute of ophthalmology, University College 

London, London, United Kingdom 

4503 — 12:30 Identification of further novel 

genome wide significant loci for open angle 

glaucoma blindness utilizing the Australian 

and New Zealand Registry of Advanced 

Glaucoma. Jamie E. Craig 1 , A. W. Hewitt 2, 1 , 

S. Graham 3 , P. R. Healey 4 , R. J. Casson 5 , P. 

Mitchell 4 , J. Landers 1 , S. MacGregor 6 , D. A. 

Mackey 2 , K. P. Burdon 1 . 1 Ophthalmology, Flinders 

University, Bedford Park, Adelaide, SA, Australia; 

2 

Ophthalmology, Lions Eye Institute, Perth, WA, 

Australia; 3 Ophthalmology, Macquarie University, 

Sydney, NSW, Australia; 4 Ophthalmology, 

Sydney University, Sydney, NSW, Australia; 

5 

Ophthalmology, Adelaide University, Adelaide, 

SA, Australia; 6 Queensland Institute of Medical 

Research, Brisbane, QLD, Australia *CR 

6C 


Retina 

425 AMD: Novel and 

Combination Therapies 

Moderators: Susanne Binder and Pravin U. Dugel 

4504 — 11:00 Anti-VEGF Gene Therapy for 

Wet AMD: Safety and Tolerability of Subretinal 

Delivery in a Phase I/II Clinical Trial. Ian 

Constable 1, 2 , C. Pierce 2 , S. K. Somasundaram 2 , 

M. Lai 1, 2 , T. W. Chalberg 3 , M. S. Blumenkranz 4 , 

R. Samulski 5 , E. P. Rakoczy 1, 2 . 1 Centre for 

Ophthalmology and Visual Sciences, University 

of Western Australia, Perth, WA, Australia; 2 Lions 

Eye Institute, Perth, WA, Australia; 3 Avalanche 

Biotechnologies, San Francisco, CA; 4 Byers Eye 

Institute at Stanford, Palo Alto, CA; 5 Pharmacology 

and Gene Therapy Center, University of North 

Carolina, Chapel Hill, NC *CR, f 

4505 — 11:15 Phase I, Masked, Placebo- 

Controlled, Single and Multiple Ascending 

Intravenous Dose Studies Evaluating Systemic 

and Ocular Safety, Tolerability, and Visual 

Acuity Effects of RN6G (PF-04382923) in 

Subjects with Dry, Age-Related Macular 

Degeneration (ARMD). Brian B. Berger 1 , P. 

D. Garzone 2 , I. Gunderson 1 , P. M. Fanning 2 , G. 

Wong 2 , K. H. Liao 2 , S. Y. Hua 2 , J. Lin 2 . 1 Retina 

Research Center, Austin, TX; 2 Pfizer Inc., South San 

Francisco, CA *CR, f 

4506 — 11:30 A Phase 2 Double-masked, 

Placebo-controlled, Dose Ranging Study of 

Emixustat Hydrochloride (ACU-4429) in 

Subjects with GA Associated with Dry AMD. 

Pravin U. Dugel 1 , R. L. Novack 2 , K. G. Csaky 3 , P. 

P. Richmond 4 , D. G. Birch 5 , R. Kubota 6 . 1 Retinal 

Consultants of Arizona, Ltd, Phoenix, AZ; 2 Retina- 

Vitreous Associates Medical Group, Beverly Hills, 

CA, Beverly Hills, CA; 3 Texas Retina Associates, 

Dallas, TX, Dallas, TX; 4 Central Florida Retina, 

Orlando, FL, Orlando, FL; 5 Retina Foundation of 

Southwest, Dallas, TX, Dallas, TX; 6 Acucela Inc., 

Seattle, WA, Seattle, WA *CR, f 

4507 — 11:45 Photodynamic Therapy vs 

Combination Therapy in Polypoidal Choroidal 

Vasculopathy: Changes of Aqueous Vascular 

Endothelial Growth Factor. Meeyon Lee 1 , W. Lee 2 . 

1 

Chung ang University hospital, Seoul, Republic of 

Korea; 2 Seoul St. Mary hospital, Seoul, Republic of 

Korea *CR, f 

4508 — 12:00 Twelve Months Results 

Comparing Ranibizumab or Bevacizumab 

Treatment in Patients with Neovascular Agerelated 

Macular Degeneration(AMD) Multicenter 

Anti-VEGF Trial in Austria The Manta Study. 

Susanne Binder 1 , I. Krebs 1 , L. Schmetterer 2 . 

1 

Ophthalmology, Rudolf Foundation Clinic, Vienna, 

Austria; 2 Department of Clinical Pharmacology, 

Medical University, Vienna, Austria f 


Minisymposium 

11:00 am – 12:45 pm 


293



Minisymposium 

11:00 am – 12:45 pm 

4509 — 12:15 Long-Term and Lasting 

Outcomes of Combination Treatment for 

Age-Related Macular Degeneration with 

Photodynamic Therapy and Intravitreal 

Injection of Anti-Vascular Endothelial Growth 

Factor. Colleen M. McLellan, R. Silva-Garcia, K. 

W. Small. Molecular Insight Research Foundation, 

Glendale, CA *CR 

6E 


Retina 

426 Macular Disease Other 

Than AMD II 

Moderators: William F. Mieler and 

K. Bailey Freund 

4510 — 11:00 Occult Central Serous 

Chorioretinopathy. K Bailey Freund 1, 2 , D. 

Warrow 3 , R. Gallego-Pinazo 1, 5 , Q. V. Hoang 4 . 

1 

Ophthalmology, Vitreous Retina Macula 

Consultants New York, New York, NY; 

2 

Ophthalmology, New York University, New 

York, NY; 3 Ophthamology, New York Eye and 

Ear Infirmary, New York, NY; 4 Ophthalmology, 

Columbia University, New York, NY; 

5 

Ophthalmology, University and Polytechnic 

Hospital La Fe, Valencia, Spain *CR 

4511 — 11:15 Effect of Somatostatin on the 

expression of tight junctions and urokinase 

plasminogen activator receptor in human retinal 

pigment epithelial cells. Alex Fonollosa 1, 2 , J. 

Artaraz 1 , A. Martinez-Berriotxoa 1 , E. Vecino 2 . 

1 

Ophthalmology, Hospital de Cruces, Portugalete, 

Spain; 2 Grupo de Oftalmobiologia Experimental, 

Bilbao, Spain 

4512 — 11:30 Selective Laser Photocoagulation 

of Peripheral Non-perfused Retinal Areas 

May Improve the Vision in Patients with 

Central Retinal Vein Occlusion Treated with 

Ranibizumab. Matus Rehak 1 , A. Franke 2 , P. M. 

Wiedemann 1 . 1 Department of Ophthalmology, 

University of Leipzig, Leipzig, Germany; 2 Clinical 

Trial Centre (ZKS) Leipzig, University of Leipzig, 

Leipzig, Germany *CR, f 

4513 — 11:45 Macular Bruchs Membrane 

Defects and Axial Length: Association with 

Gamma Zone and Delta Zone in Peripapillary 

Region. Jost B. Jonas 1 , K. Ohno-Matsui 2 , 

R. F. Spaide 3 , L. Holbach 4 , S. Panda-Jonas 1 . 

1 

Ophthalmology, Medical Faculty Mannheim- 

Heidelberg, Mannheim, Germany; 2 Department 

of Ophthalmology and Visual Science, Tokyo 

Medical and Dental University, Tokyo, Japan; 

3 

Vitreous-Retina-Macula Consultants of New 

York and the LuEsther T. Mertz Retinal Research 

Center, Manhattan Eye, Ear, and Throat Hospital, 

New York, NY; 4 Department of Ophthalmology, 

Friedrich-Alexander University Erlangen-Nürnberg, 

Erlangen, Germany *CR 

4514 — 12:00 Treatment Experience with 

Intravitreal Aflibercept Injection (IAI) After 

Switching to PRN Dosing in Patients with 

Macular Edema Secondary to Central Retinal 

Vein Occlusion (CRVO). David M. Brown 1 , F. G. 

Holz 2 . 1 Retina Consultants of Houston, Houston, 

TX; 2 Department of Ophthalmology, University of 

Bonn, Bonn, Germany *CR, f 

4515 — 12:15 Two-Year Results of the 

COPERNICUS Study Evaluating Intravitreal 

Aflibercept Injection (IAI) for Macular Edema 

Secondary to Central Retinal Vein Occlusion 

(CRVO). W. Lloyd Clark. Palmetto Retina Center, 

West Columbia, SC *CR, f 

4516 — 12:30 Eighteen-Month Results of 

the GALILEO Study Evaluating Intravitreal 

Aflibercept Injection (IAI) for Macular Edema 

Secondary to Central Retinal Vein Occlusion 

(CRVO). Yuichiro Ogura 1 , J. Korobelnik 2 , J. 

Roider 3 , R. Vitti 4 , F. G. Holz 5 , F. Hiemeyer 6 , B. 

Stemper 6 , O. Zeitz 6 , R. Sandbrink 6 . 1 Department 

of Ophthalmology, Nagoya City University 

Medical School, Nagoya, Japan; 2 Department 

of Ophthalmology, CHU Bordeaux, Universite 

Bordeuax, Bordeaux, France; 3 Department of 

Ophthalmology, University Medical Center 

Schleswig-Holstein, Kiel, Germany; 4 Regeneron 

Pharmaceuticals Inc., Tarrytown, NY; 5 Department 

of Ophthalmology, University of Bonn, Bonn, 

Germany; 6 Bayer Healthcare, Berlin, Germany 

*CR, f 

606/607 


Immunology/Microbiology 

427 Ocular Immune Responses 

Moderators: Holly L. Rosenzweig and 

Thomas Langmann 

4517 — 11:00 Loss of MicroRNA-124 

and MicroRNA-126 expression regulates 

inflammatory microglial activation in inherited 

retinal degeneration. Thomas Langmann 1, 2 , C. 

Moehle 3 , M. Karlstetter 1 , B. H. Weber 2 . 1 Department 

of Ophthalmology, University of Cologne, Cologne, 

Germany; 2 Institute of Human Genetics, University 

of Regensburg, Regensburg, Germany; 3 Center of 

Excellence for Fluorescent Bioanalytics, University 

of Regensburg, Regensburg, Germany 

4518 — 11:15 Mice lacking TNFR1 develop 

less angiogenesis during late stage experimental 

autoimmune uveoretinitis (EAU). Madeleine 

Stimpson 1 , J. Liu 1 , D. A. Copland 1 , T. K. Khera 1 , 

A. D. Dick 1, 2 . 1 Academic Unit of Ophthalmology, 

University of Bristol, Bristol, United Kingdom; 

2 

Cellular and Molecular Medicine, University of 

Bristol, Bristol, United Kingdom *CR 

4519 — 11:30 Differential effects of TLR- 

3 activated RPE on retinal microglia and 

blood-derived monocytes. Alexa K. Klettner 1 , 

T. Hamann 1 , S. Wilker 1 , C. Berg 1 , K. Schlüter 1 , R. 

Lucius 2 , M. Rolf 2 , J. Roider 1 . 1 Ophthalmology, Univ 

of Kiel, Kiel, Univ Medical Center, Kiel, Germany; 

2 

Anatomy, University of Kiel, Kiel, Germany *CR 

4520 — 11:45 Demonstration of Donor T cell 

Recruitment and Correlation with Inflammatory 

Cytokine Presence in Experimental Ocular 

Graft-versus-Host Disease. Samantha Herretes 1 , 

J. C. Murillo 1 , D. Ross 2 , H. Barreras 2 , Y. Tan 1 , A. M. 

Saeed 1 , A. Gonzalez 1 , C. Betancurt 1 , R. B. Levy 2 , V. 

L. Perez 1, 2 . 1 Ophthalmology, Bascom Palmer Eye 

Inst, Univ of Miami, Miami, FL; 2 Immunology and 

Microbiology, University of Miami, Miami, FL *CR 

4521 — 12:00 Monophasic PDSAg-induced 

EAU dominates over relapsing R14-induced 

EAU. Ulrike Kaufmann, M. Diedrichs-Möhring, 

G. Wildner. Ophthalmology, Clinic of the Ludwig- 

Maximilians-University, Munich, Germany 

4522 — 12:15 Inhibition of Vascular 

Endothelial Growth Factor Ameliorates Ocular 

Allergy in the Murine Model. Daniel R. Saban 1 , 

R. Dana 2 , H. Lee 2 , T. Blanco 1 . 1 Ophthalmology, 

Duke University School of Medicine, Durham, NC; 

2 

Ophthalmology, Schepens Eye Res Inst, Mass. Eye 

& Ear, Harvard Medical School, Boston, MA *CR 

4523 — 12:30 Translational Modeling of 

Calpain-5 Vitreoretinopathy Mechanisms 

in Mice. Vinit B. Mahajan 1, 2 , K. J. Wert 3 , J. M. 

Skeie 1, 2 , S. H. Tsang 4 . 1 Ophthalmology, University 

of Iowa, Iowa City, IA; 2 Omics Laboratory, 

University of Iowa, Iowa City, IA; 3 Institute of 

Human Nutrition, Columbia University, New York, 

NY; 4 Ophthalmology, Columbia University, New 

York, NY 

608 



428 Uveal Melanoma: Experimental 

Therapeutics 

Moderators: Hans Grossniklaus, Sarah E. 

Coupland and Arun D. Singh 

4524 — 11:00 Microphthalmia-associated 

transcription factor (MITF) and Steroid 

Receptor Coactivator (SRC)-3 cooperate to 

promote proliferation, survival and metabolism 

in Gα-mutant uveal melanoma (UM) cells. 

Vassiliki Poulaki 1, 2 , S. Chew 3, 4 , B. He 3, 4 , V. 

Eedunuri 5 , M. M. Jager 6 , B. W. O’Malley 4 , 

N. Mitsiades 3, 4 . 1 Ophthalmology, Boston VA 

Healthcare System, Boston, MA; 2 Ophthalmology, 

Boston University, Boston, MA; 3 Medicine, 

Baylor College of Medicine, Houston, TX; 

4 

Molecular and Cellular Biology, Baylor College 

of Medicine, Houston, TX; 5 Adrienne Helis Malvin 

Medical Research Foundation, New Orleans, LA; 

6 

Ophthalmology, Leiden University Medical Center, 

Leiden, Netherlands 


294


4525 — 11:15 Uveal Melanoma Cells Are 

Inhibited by AICAR Partially Through 

Activation of AMP-Dependent Kinase. Ahmad 

Al Moujahed 1 , F. Nicolaou 2 , T. D. Papakostas 1 , 

J. W. Miller 1 , E. S. Gragoudas 1 , D. Vavvas 1 . 

1 

Ophthalmology, Massachusetts Eye and Ear 

Infirmary, Harvard Medical School, Boston, MA; 

2 

Pediatric Surgery Laboratories, Massachusetts 

General Hospital, Boston, MA *CR 

4526 — 11:30 SRPK1 Inhibition, As A Way Of 

Targeting Pro-Angiogenic VEGF-A Production 

In Ocular Tumours. Melissa V. Gammons 1 , S. E. 

Coupland 3 , A. D. Dick 2 , D. O. Bates 1 . 1 Department 

of Physiology and Pharmacology, University 

of Bristol, Bristol, United Kingdom; 2 School of 

Clinical Sciences and School of Cellular and 

Molecular medicine, University of Bristol, Bristol, 

United Kingdom; 3 Department of Molecular and 

Clinical Cancer Medicine, University of Liverpool, 

Liverpool, United Kingdom *CR 

4527 — 11:45 Targeting Uveal Melanoma 

Response to Hypoxia. Dudi Shneor 1, 2 , A. 

Honigman 2 , J. Pe’er 1 , S. Frenkel 1 . 1 Ophthalmology, 

Hadassah-Hebrew University Medical Center, 

Jerusalem, Israel; 2 Biochemistry and Molecular 

Biology, IMRIC, The Hebrew University-Hadassah 

Medical School, Jerusalem, Israel 

4528 — 12:00 Efficacy of A Novel Anti-tumor 

Agent KCN1 in the Control of Ocular Melanoma 

In vitro and In vivo. Qing Zhang 1, 2 , H. Yang 1 , 

S. Kaluz 3 , E. G. Van Meir 3, 4 , H. E. Grossniklaus 1, 

5 

. 1 Ophthalmology, Emory University School of 

Medicine, Atlanta, GA; 2 Ophthalmology, Central 

South University Xiangya School of Medicine, 

Changsha, China; 3 Neurosurgery, Winship Cancer 

Institute, Emory University School of Medicine, 

Atlanta, GA; 4 Hematology and Medical Oncology, 

Emory University School of Medicine, Atlanta, GA; 

5 

Pathology, Emory University School of Medicine, 

Atlanta, GA *CR 

4529 — 12:15 NFkB Inhibition in Uveal 

Melanoma - Contrariety of in vitro vs. in vivo 

Results. Shahar Frenkel 1 , D. Shneor 2, 1 , J. Pe’er 1 , 

A. Honigman 2 . 1 Ophthalmology, Hadassah-Hebrew 

University Medical Center, Jerusalem, Israel; 

2 

Biochemistry and Molecular Biology, IMRIC, 

The Hebrew University-Hadassah Medical School, 

Jerusalem, Israel 

4530 — 12:30 Identification of regulators 

of uveal melanoma metastasis through whole 

exome sequencing. Sarah Lake 1 , B. E. Damato 2 , 

H. Kalirai 1 , L. Olohan 3 , X. Liu 3 , S. E. Coupland 1 . 

1 

Molecular And Clinical Cancer Medicine, 

University of Liverpool, Liverpool, United 

Kingdom; 2 Royal Liverpool University Hospital, 

Liverpool, United Kingdom; 3 Centre for Genomic 

Research, University of Liverpool, Liverpool, 

United Kingdom 

609 


Lens 

429 A Global View of Posterior Capsule 

Opacification - Minisymposium 

Posterior Capsule Opacification (PCO) is the most 

common complication of cataract surgery, which 

essentially forms by a lens wound-healing response 

induced by surgical trauma. Despite advances in 

artificial lens implants to delay PCO formation, 

significant numbers of patients still experience 

visual deterioration that requires laser surgery to 

resolve the problem. PCO is therefore far from 

eradicated and requires communication between 

industry, clinicians and scientists to best understand 

the problem and determine novel strategies to 

delay or eliminate PCO formation. The proposed 

minisymposium will bring together these different 

communities to discuss this important problem. 

Moderators: Michael Wormstone, Melinda K. 

Duncan and Steven Bassnett 

— 11:00 Introduction 

4531 — 11:05 Polymers, Barriers and Haptics: 

The Development of IOLSs in the Prevention 

of PCO. David Spalton. Consulting Rooms, King 

Edward VII Hospital, London, United Kingdom 

*CR 

4532 — 11:30 Differentiation in the Lens: 

Implications for PCO. Linda Musil. Biochemistry 

& Molecular Biology, Oregon Health & Science 

Univ, Portland, OR 

4533 — 11:55 Lens Cell/ECM Interactions in 

PCO. Melinda K. Duncan. Biological Sciences, 

University of Delaware, Newark, DE 

4534 — 12:20 TGFbeta and PCO: Why Old 

Bags Wrinkle. Michael Wormstone. School of 

Biological Sciences, University of East Anglia, 

Norwich, United Kingdom *CR 

611-614 



430 Physiologic Vascularization 

in Retinopathies 

Moderators: Azza B. El-Remessy and Alan W. Stitt 

4535 — 11:00 Inhibiting the Ras Pathway 

Prevents Ocular Neovascularization by 

Repressing Tip Cell Sprouting. Peter D. 

Westenskow, T. Kurihara, E. Aguilar, M. Webb, 

C. M. Wittgrove, S. K. Moreno, M. Friedlander. 

Department of Cell Biology, The Scripps Research 

Institute, La Jolla, CA 

4536 — 11:15 Endothelial Progenitor Cells 

in Bone Marrow, Blood, and Retina Respond 

Dynamically to Murine Oxygen-Induced 

Retinopathy. Bliss E. O’Bryhim 1, 2 , R. White 1 , R. C. 

Symons 1, 3 . 1 Ophthalmology, University of Kansas 

Medical Center, Kansas City, KS; 2 Molecular & 

Integrative Physiology, Univ of Kansas Medical 

Center, Kansas City, KS; 3 Department of Surgery, 

University of Melbourne, Melbourne, VIC, 

Australia 

4537 — 11:30 Neuronal Sirtuin1 mediates 

retinal vascular regeneration in retinopathy. Jing 

Chen, A. Juan, C. G. Hurst, D. T. Pei, J. Joyal, L. 

Evans, Z. Cui, A. Stahl, P. Sapieha, L. E. Smith. 

Ophthalmology, Harvard Med Sch Children’s Hosp, 

Boston, MA 

4538 — 11:45 Vascular Protective Effects of 

Candesartan In Ischemic Retinopathy. Azza B. 

El-Remessy 1, 2 , A. Y. Shanab 1, 2 , S. Matragoon 1, 2 , S. 

C. Fagan 1, 2 . 1 Clin & Experimental Therapeutics, 

University of Georgia, Augusta, GA; 2 VA Medical 

Center, Augusta, GA *CR 

4539 — 12:00 Senescent endothelial progenitor 

cells show impaired vasoregenerative capacity 

in the ischemic retina. Emma Reid 1 , R. J. Medina 1 , 

M. O’Doherty 1 , C. L. O’Neill 1 , S. Wilson 1 , J. 

Guduric-Fuchs 1 , J. Neisen 2 , D. J. Waugh 2 , D. A. 

Simpson 1 , A. W. Stitt 1 . 1 Centre for Vision & Vascular 

Science, Queen’s University Belfast, Belfast, 

United Kingdom; 2 Centre for Cancer Research and 

Cell Biology, Queen’s University Belfast, Belfast, 


4540 — 12:15 Lack of Cyp1B1 Promotes 

the Proliferative and Migratory Phenotype of 

Perivascular Supporting Cells. Nader Sheibani 1 , 

T. L. Palenski 1 , C. M. Sorenson 2 . 1 Ophthalmology 

and Visual Sciences, Univ of Wisconsin-Madison, 

Madison, WI; 2 Pediatrics, Uinversity of Wisconsin, 

Madison, WI 

4541 — 12:30 Laminin Regulation of Retinal 

Vascularization: Role in Astrocyte Migration 

and Differentiation. William J. Brunken 1, 2 , 

G. Bachay 1, 2 , S. Biswas 1, 2 , G. Gnanaguru 1, 2 . 

1 

Ophthalmology and Cell Biology, SUNY 

Downstate Medical Center, Brooklyn, NY; 2 SUNY 

Eye Institute, Brooklyn, NY 


Minisymposium 

11:00 am – 12:45 pm 


295



Minisymposium 

11:00 am – 12:45 pm 

615-617 



431 Eye Care: Who’s Not Getting It and 

Why It Matters 

Moderators: Pradeep Y. Ramulu and 

Nakul Shekhawat 

4542 — 11:00 Does government assistance 

improve access for low-income individuals to 

eye care providers? Chris J. Hong 1 , G. E. Trope 2 , 

Y. M. Buys 2 , B. E. Robinson 4 , Y. Jin 2, 3 . 1 Department 

of Medicine, University of Ottawa, Ottawa, ON, 

Canada; 2 Department of Ophthalmology and 

Vision Sciences, University of Toronto, Toronto, 

ON, Canada; 3 Dalla Lana School of Public Health, 

University of Toronto, Toronto, ON, Canada; 

4 

School of Optometry, University of Waterloo, 

Waterloo, ON, Canada *CR 

4543 — 11:15 The Association of Vision Loss 

with Work Status in the United States. Cheryl 

Sherrod 2, 1 , K. D. Frick 3, 5 , P. Y. Ramulu 4, 1 . 1 Dana 

Center for Preventive Ophthalmology, Wilmer 

Eye Institute at Johns Hopkins, Baltimore, MD; 

2 

Preventive Medicine, Johns Hopkins Bloomberg 

School of Public Health, Baltimore, MD; 3 Health 

Policy & Management, Johns Hopkins Bloomberg 

School of Public Health, Baltimore, MD; 

4 

Glaucoma Division, Wilmer Eye Institute at Johns 

Hopkins, Baltimore, MD; 5 International Health, 

Johns Hopkins Bloomberg School of Public Health, 

Baltimore, MD *CR 

4544 — 11:30 Despite Possessing Health 

Insurance, Large Disparities Exist in Likelihood 

of Visits to Eye Care Providers Across U.S. 

Sociodemographic Groups. Patricia A. Pleplakon 

1 , C. A. Andrews 1 , D. C. Musch 1, 2 , P. P. 

Lee 1 , J. D. Stein 1 . 1 Ophthalmology and Visual 

Sciences, University of Michigan, Ann Arbor, MI; 

2 

Epidemiology, University of Michigan, Ann Arbor, 

MI *CR 

4545 — 11:45 The global burden of potential 

productivity loss from presbyopia. Susan M. 

Joy 1 , K. D. Frick 1 , K. S. Naidoo 2 , D. A. Wilson 2 , 

B. A. Holden 2, 3 . 1 Department of Health Policy 

and Management, Johns Hopkins Bloomberg 

School of Public Health, Baltimore, MD; 2 Brien 


3 

University of New South Wales, Sydney, NSW, 

Australia *CR 

4546 — 12:00 An Evaluation of Non-Physician 

Educators’ Role In Enhancing Cataract Patient’s 

Surgical Knowledge and Satisfaction. Paula 

Anne Newman-Casey 1 , S. Ravilla 2 , H. Aravind 2 , 

V. Palanichamy 2 , M. Pillai 2 , V. Balakrishnan 2 , A. 

L. Robin 3 . 1 Ophthalmology & Visual Sciences, 

Kellogg Eye Ctr, Univ of Michigan, Ann Arbor, 

MI; 2 Ophthalmology and Visual Sciences, Aravind 

Eye Care System, Madurai, India; 3 Ophthalmology 

and Visual Sciences, Johns Hopkins University, 


4547 — 12:15 Cohort- and age-specific 

effects of annual mass drug administration on 

prevalence of trachoma: a longitudinal study in 

rural Tanzania. Nakul Shekhawat 1, 2 , B. E. Munoz 1 , 

H. A. Mkocha 3 , S. K. West 1, 2 . 1 Dana Center for 

Preventative Ophthalmology, Wilmer Eye Institute, 

Johns Hopkins, Baltimore, MD; 2 Johns Hopkins 

Bloomberg School of Public Health, Baltimore, 

MD; 3 Kongwa Trachoma Project, Kongwa, United 

Republic of Tanzania 

4548 — 12:30 Time-Motion Analysis of Clinical 

Nursing Documentation during Implementation 

of an Electronic Operating Room Management 

System for Ophthalmic Surgery. Sarah Read- 

Brown 1 , A. S. Brown 1 , T. R. Yackel 2 , D. Choi 3 , 

D. C. Tu 1, 4 , D. S. Sanders 1 , M. F. Chiang 1, 2 . 

1 


University, Portland, OR; 2 Medical Informatics & 


University, Portland, OR; 3 Public Health & 

Preventative Medicine, Oregon Health & Science 

University, Portland, OR; 4 Portland Veterans 

Administration Medical Center, Portland, OR *CR 

TCC LL 4/5 



432 Refractive Errors, Myopia II 

Moderators: Arthur Bradley and Frank Schaeffel 

4549 — 11:00 The impact of Spherical 

Aberration, Stiles Crawford Apodization and 

Spatial Frequency on wavefront-based and 

subjective refractions. Renfeng Xu 1 , A. Bradley 1 , 

L. N. Thibos 1 , G. Marin 2 , M. Hernandez 2 . 1 School 

of Optometry, Indiana University, Bloomington, IN; 

2 

Essilor International, Paris, France *CR 

4550 — 11:15 Impact of Primary and 

Secondary Spherical Aberration on Predicted 

Peripheral Image Quality. Amanda C. Kingston 1, 2 , 

G. Yoon 2 . 1 BME, University of Rochester, 

Rochester, NY; 2 Flaum Eye Institute, University of 

Rochester, Rochester, NY *CR 

4551 — 11:30 Peripheral Wavefront 

Aberrations of Accommodating Human Eye. Tao 

Liu, L. N. Thibos. School of Optometry, Indiana 

University, Bloomington, Bloomington, IN *CR 

4552 — 11:45 1 Changes in Ocular Biometrics 

and Refraction during Near Work in Downward 

Gaze over Time. Atanu Ghosh, M. J. Collins, B. 

A. Davis, S. A. Read, F. Yi, P. Chatterjee. School 

of Optometry and Vision Science, Queensland 

University of Technology, Brisbane, QLD, Australia 

4553 — 12:00 Effect of Accommodation on 

Peripheral Refraction. Jason Shen, F. Spors. 

College of Optometry, Western Univ of Hlth 

Sciences, Pomona, CA 

4554 — 12:15 School-Age Myopic Shift in 

Hyperopic Children with Infantile Esotropia and 

Peripheral Myopia. Eileen E. Birch 1, 2 , S. Li 1 , S. E. 

Morale 1 , R. M. Jost 1 , V. Subramanian 1 , D. O. Mutti 3 . 

1 

Retina Foundation of the Southwest, Dallas, TX; 

2 

Ophthalmology, UT Southwestern Medical Center, 

Dallas, TX; 3 College of Optometry, The Ohio State 

University, Columbus, OH 

TCC 303 


Cornea / Cornea 

433 Stroma Keratocytes, Development 

and Dystrophies 

Moderators: Albert S. Jun and Sophie X. Deng 

4555 — 11:00 Wnt/b-catenin canonical 

signaling in corneal keratocytes regulates 

epithelium stratification through repressing 

Bmp4/Mapk pathway. Yujin Zhang 1 , L. Yeh 2 , 

W. W. Kao 1 , C. Liu 1 . 1 Ophthalmology, University 

of Cincinnati School of Med, Cincinnati, OH; 

2 

Ophthalmology, Chang-Gung Memorial Hospital, 

Linko, Taiwan 

4556 — 11:15 Peptide Amphiphiles as 

Versatile Substrates for Oriented Cell Adhesion 

and Proliferation of Human Cornea Stromal 

Keratocytes. Ricardo M. Gouveia, V. Castelletto, I. 

Hamley, C. J. Connon. School of Chemistry, Food 

and Pharmacy, University of Reading, Reading, 


4557 — 11:30 Limbal Biopsy As a Source of 

Stem Cells for Autologous Stromal Cell-based 

Therapy. Sayan Basu 1, 2 , M. L. Funderburgh 1 , J. 

L. Funderburgh 1 . 1 Ophthalmology, University of 

Pittsburgh School of Medicine, Pittsburgh, PA; 

2 

Cornea, L V Prasad Eye Institute, Hyderabad, India 

4558 — 11:45 Mass Spectrometric - Based 

Proteomic Analysis of TGFBI Corneal 

Dystrophies. Aarika Menees 1 , S. Dasari 2 , A. 

Dogan 2 , S. V. Patel 1 , K. H. Baratz 1 , J. D. Theis 2 , J. 

A. Vrana 2 , D. R. Salomao 2, 1 . 1 Ophthalmology, Mayo 

Clinic, Rochester, MN; 2 Laboratory Medicine and 

Pathology, Mayo Clinic, Rochester, MN *CR 

4559 — 12:00 Investigation of Gene Therapy 

Using Immortalized Cells Derived from a 

Gelatinous Drop-Like Corneal Dystrophy 

Patient. Koji Kitazawa 1 , S. Kawasaki 1 , K. 

Aoi 3, 1 , K. Shinomiya 1 , A. Matsuda 2 , T. Funaki 2 , 

M. Nakatsukasa 1 , J. Hamuro 1 , A. Murakami 2 , 

S. Kinoshita 1 . 1 Kyoto Prefectural Univ of Med, 

Kyoto, Japan; 2 Juntendo University, Tokyo, Japan; 

3 

Doshisya University, Kyoto, Japan *CR 


296


4560 — 12:15 A Family-based Investigation 

of the Role of TCF4 Trinucleotide Repeat 

Expansion in Fuchs Endothelial Corneal 

Dystrophy (FECD). Keith H. Baratz 1 , R. A. 

Aleff 2 , Y. Li 3 , M. L. Butz 4 , S. G. Gregory 5 , G. K. 

Klintworth 6 , W. Highsmith 4 , N. A. Afshari 7 , E. D. 

Wieben 2 . 1 Ophthalmology, Mayo Clinic, Rochester, 

MN; 2 BIochemistry and Molecular Biology, 

Mayo Clinic, Rochester, MN; 3 Biostatistics and 

BioInformatics, Center for Human Genetics, 

Duke University Medical Center, Durham, NC; 

4 

Laboratory Medicine and Pathology, Mayo Clinic, 

Rochester, MN; 5 Medicine, Molecular Genetics and 

Microbiology, Duke University Medical Center, 

Durham, NC; 6 Ophthalmology, Duke University 

Medical Center, Durham, NC; 7 Ophthalmology, 

University of California, San Diego, San Diego, 

CA *CR 

4561 — 12:30 AGBL1 implicated in the 

pathogenesis of late-onset FCD and interacts 

with TCF4. John D. Gottsch 1 , S. Vasanth 2 , N. 

Katsanis 2 , S. Riazuddin 1 . 1 Wilmer Eye Institute, 

Johns Hopkins University School of Medicine, 

Baltimore, MD; 2 Center for Human Disease 

Modeling, Duke University Medical Center, 

Durham, NC 

TCC 304 



434 Genetics, Development and Aging 

Moderators: Rachel O. Wong and Anand Swaroop 

4562 — 11:00 Distinct Roles Of Activity- 

Dependent And Independent Mechanisms 

In Regulating The Bipolar Cell Inputs Onto 

Retinal Ganglion Cells. Haruhisa Okawa 1 , L. 

Della Santina 1 , G. Schwartz 2 , D. Kerschensteiner 3 , 

F. Rieke 2 , R. O. Wong 1 . 1 Biological Structure, 

University of Washington, Seattle, WA; 2 Physiology 

and Biophysics, University of Washington, 

Seattle, WA; 3 Ophthalmology and Visual Sciences, 

Washington University, St. Louis, MO 

4563 — 11:15 Following the Ontogeny of 

Retinal Waves: Pan-Retinal Recordings of 

Population Dynamics in the Neonatal Mouse. 

Evelyne Sernagor 1 , M. H. Hennig 2 , A. Maccione 3 , 

M. Gandolfo 3 , J. Muthmann 2 , S. J. Eglen 4 , L. 

Berdondini 3 . 1 Institute of Neuroscience, Newcastle 

Univ Medical School, Newcastle Upon Tyne, 

United Kingdom; 2 Institute for Adaptive and Neural 

Computation, School of Informatics, University of 

Edinburgh, Edinburgh, United Kingdom; 3 Dept. 

of Neuroscience and Brain Technologies, Italian 

Institute of Technology, Genova, Italy; 4 Cambridge 

Computational Biology Institute, Cambridge 

University, Cambridge, United Kingdom *CR 

4565 — 11:45 Epigenetic maintenance of 

adult cone photoreceptors. Volker Busskamp 1, 2 , 

J. Krol 2 , K. Farrow 2 , J. Juettner 2 , D. Nelidova 2 , V. 

Sothilingam 3 , M. Garcia Garrido 3 , M. W. Seeliger 3 , 

W. Filipowicz 2 , B. Roska 2 . 1 Genetics, Harvard 

Medical School, Boston, MA; 2 Friedrich Miescher 

Institute, Basel, Switzerland; 3 Division of Ocular 

Neurodegeneration, Institute for Ophthalmic 

Research, Tuebingen, Germany *CR 

4566 — 12:00 Down-regulation of oxidative 

phosphorylation genes and up-regulation 

of protein degradation pathway genes are a 

hallmark of aging rod photoreceptors in mouse 

retina. Tiziana Cogliati 1 , J. Barb 2 , N. Gotoh 3 , M. 

Brooks 1 , L. Gieser 1 , N. Gupta 1 , R. Villasmil 4 , I. 

Lee 5 , P. J. Munson 2 , A. Swaroop 1 . 1 NNRL, National 

Eye Institute - NIH, Bethesda, MD; 2 CIT, NIH, 

Bethesda, MD; 3 Department of Ophthalmology and 

Visual Sciences, Kyoto University, Kyoto, Japan; 

4 

Flow Cytometry Core, National Eye Institute - 

NIH, Bethesda, MD; 5 MirCore, Ann Arbor, MI *CR 

4567 — 12:15 Synaptic localization but not 

specificity is mediated by Down Syndrome Cell 

Adhesion Molecule. Peter G. Fuerst 1, 2 , S. Li 1 , 

D. Schramm 1 . 1 Biological Sciences, University of 

Idaho, Moscow, ID; 2 UWSOM WWAMI Medical 

Education Program, University of Idaho, Moscow, 

ID 

4568 — 12:30 Developmental changes in 

subunit- and pathway-specific expression of 

NMDA receptors in direction-selective ganglion 

cells. Ben Stafford 1 , K. Y. Wong 1, 2 , J. B. Demb 3 . 

1 


of Michigan, Ann Arbor, MI; 2 Molecular, Cell, and 

Developmental Biology, University of Michigan, 

Ann Arbor, MI; 3 Ophthalmology and Visual 

Sciences, Yale University, New Haven, CT 

TCC 305 




435 Neuro-Ophthalmology: Novel 

Treatments and Mechanisms of Disease 

Moderators: Yaping J. Liao and 

Prem S. Subramanian 

4569 — 11:00 MTS-AAV Delivery of Human 

ND4 in the Mouse Eye. John Guy 1 , H. Yu 1 , A. 

Mehta 2 , G. Wang 2 . 1 Bascom Palmer Eye Institute, 

University of Miami, Miami, FL; 2 Genomics, 

Hussman Institute of Human Genomics, Miami, FL 

4570 — 11:15 Retinal ganglion cells exhibit 

spontaneous hyperactivity and abnormally 

sustained light-evoked responses in in a mouse 

model of traumatic brain injury. Matthew 

Harper 1 , F. R. Blodi 2, 4 , M. Shankar 2, 4 , E. 

Hernandez-Merino 1, 3 , H. Kecova 1, 3 , L. Dutca 1, 3 , 

R. H. Kardon 1, 3 , S. F. Stasheff 2, 3 . 1 Center for 

the Prevention and Treatment of Visual Loss, 

Department of Veterans Affairs, Iowa City, IA; 

2 

Pediatrics, University of Iowa, Iowa CIty, IA; 

3 

Ophthalmology and Visual Science, University 

of Iowa, Iowa CIty, IA; 4 Children’s Hospital, 

University of Iowa, Iowa CIty, IA *CR 

4571 — 11:30 TrkB Neurotrophin Receptor 

Activation with Pharmacophore as Possible 

Treatment for Anterior Ischemic Optic 

Neuropathy. Yaping J. Liao 1 , G. Lee 1 , J. Ma 1 , T. 

Yang 2 , C. Chakraborty 2 , B. Barres 3 , F. Longo 2 , M. 

Shariati 1 . 1 Ophthalmology, Byers Eye Institute 

at Stanford, Stanford, CA; 2 Neurology, Stanford, 

Stanford, CA; 3 Neurobiology, Stanford, Stanford, 

CA 

4572 — 11:45 Genotype-retinal phenotype 

correlations in infantile nystagmus. Mervyn G. 

Thomas 1 , V. Sheth 1 , R. J. McLean 1 , F. A. Proudlock 1 , 

G. Maconachie 1 , S. Kohl 4 , W. Chan 2 , C. Andrews 2 , 

E. C. Engle 2, 3 , I. Gottlob 1 . 1 Ophthalmology Group, 

University of Leicester, Leicester, United Kingdom; 

2 

Department of Neurology, Boston Children’s 

Hospital, Boston, MA; 3 Departments of Neurology, 

Ophthalmology, Medicine (Genetics), Harvard 

Medical School and Boston Children’s Hospital, 

Boston, MA; 4 Centre for Ophthalmology, Institute 

for Ophthalmic Research, Tuebingen, Germany 

4573 — 12:00 Visual outcomes of the 

surgical treatment of idiopathic intracranial 

hypertension. Prem S. Subramanian 1, 2 , P. 

Fonseca 1 , N. R. Miller 1, 2 , D. Rigamonti 2 . 1 Wilmer 

Eye Institute, Baltimore, MD; 2 Neurosurgery, Johns 

Hopkins Unversity Sch of Med, Baltimore, MD 

*CR 

4574 — 12:15 Treatment of Leber’s hereditary 

optic neuropathy (LHON): Results using a 

novel quinone, EPI-743. Carlos F. Chicani 1, 2 , 

E. R. Chu 2 , F. N. Ross-Cisneros 2 , S. Rockwell 2 , K. 

Murase 3 , M. Thoolen 3 , G. Miller 3, 4 , A. A. Sadun 2 . 

1 

Ophthalmology, Federal University of Sao Paulo 

- UNIFESP, Sao Paulo, Brazil; 2 Ophthalmology, 

Doheny Eye Institute - University of Southern 

California - Keck School of Medicine, Los Angeles, 

CA; 3 Edison Pharmaceuticals, Mountain View, CA; 

4 

Anesthesiology, Stanford University, Stanford, CA 

*CR 


Minisymposium 

11:00 am – 12:45 pm 

4564 — 11:30 Dendrites of melanopsin 

ganglion cells transiently extend into the outer 

retina in early postnatal development. Jordan 

M. Renna, D. K. Chellappa, M. E. Estevez, D. 

M. Berson. Neuroscience, Brown University, 

Providence, RI 


297

4575 – Wednesday – Papers/Minisymposium 

4575 — 12:30 A Phase I Open Label, Dose 

Escalation Trial Of QPI-1007 Delivered By A 

Single Intravitreal (IVT) Injection To Subjects 

With Low Visual Acuity And Acute Non- 

Arteritic Anterior Ischemic Optic Neuropathy 

(NAION). Andrew N. Antoszyk 1, 2 , B. Katz 3 , 

R. Singh 4 , R. Gurses-Ozden 5 , S. S. Erlich 5 , D. 

Rothenstein 5 , N. Sharon 5 , J. Hodge 5 , L. A. Levin 6, 7 , 

N. R. Miller 8 . 1 Retina, Charlotte EEN&T Associates, 

Charlotte, NC; 2 Surgery, Uniformed Services 

University of the Health Sciences, Bethesda, MD; 

3 


of Utah Health Sciences Center, Salt Lake City, 

UT; 4 Ophthalmology, Cleveland Clinic Foundation, 

Cleveland, OH; 5 Quark Pharmaceuticals, Inc., 

Fremont, CA; 6 Ophthalmology, McGill University, 

Montreal, QC, Canada; 7 Ophthalmology and Visual 

Sciences, University of Wisconsin, Madison, WI; 

8 

Wilmer Eye Institute, Johns Hopkins University, 

Baltimore, MD *CR, f 


Minisymposium 

11:00 am – 12:45 pm 


298




Biochemistry/Molecular Biology 

436 AMD I, BI 

Moderator: Aparna Lakkaraju 

4576 — A0095 Autophagy disregulation in 

the retina during aging and neurodegeneration. 

Enrique J. de la Rosa 1 , N. Rodriguez-Muela 2 , 

H. Koga 3 , L. Garcia-Ledo 2 , P. de la Villa 4 , A. M. 

Cuervo 3 , P. Boya 2 . 1 Cell & Molecular Medicine, 

Centro de Investigaciones Biologicas, Madrid, 

Spain; 2 Cell & Molecular Biology, Centro de 

Investigaciones Biologicas CSIC, Madrid, Spain; 

3 

Institute for Aging Studies, Albert Einstein College 

of Medicine, Bronx, NY; 4 Physiology, School of 

Medicine, University of Alcala, Alcala de Henares, 

Spain *CR 

4577 — A0096 High glucose activates 

ChREBP-mediated HIF-1α and VEGF 

expression in human RPE cells under normoxia. 

Min-Lee Chang, C. Chiu, F. Shang, A. Taylor. 

HNRCA Tufts University, Boston, MA 

4578 — A0097 AMD-associated silent 

polymorphisms in HtrA1 ameliorate IGF-1 

antagonism. Sarah Melissa P. Jacobo 1, 2 , M. M. 

DeAngelis 3, 4 , A. Kazlauskas 1, 2 . 1 Ophthalmology, 

Harvard Medical School, Boston, MA; 2 The 

Schepens Eye Research Institute, Boston, MA; 

3 


of Utah, Salt Lake City, UT; 4 John A. Moran Eye 

Center, Salt Lake City, UT 

4579 — A0098 Differences in Reactive Oxygen 

Species (ROS) Production and Expression of 

Genes from the Complement and Inflammatory 

Pathways Between H and K Haplogroup 

Cybrids. Javier Cáceres del Carpio 1 , M. Tarek 1 , 

C. A. Ramirez 1 , P. Falatoonzadeh 1 , M. Chwa 1 , 

D. Malik 1 , S. Jazwinski 2 , M. V. Michael 2 , B. D. 

Kuppermann 1 , C. M. Kenney 1 . 1 Gavin Herbert Eye 

Institute, University of California Irvine, Irvine, 

CA; 2 Tulane Center for Aging, Tulane University, 

New Orleans, LA *CR 

4580 — A0099 Stimulation of Semaphorin3E/ 

PlexinD1 pathway has anti-angiogenic 

effect in experimental model of choroidal 

neovascularization. Kenji Suda, C. Guo, A. Oishi, 

S. Ikeda, N. Yoshimura. Ophthalmology, Kyoto 

University, Kyoto, Japan *CR 

4581 — A0100 Adiponectin Peptide II 

(APNpII) effect on human ARPE-19 cells. 

Puran S. Bora, N. S. Bora, V. V. Lyzogubov. 

Ophthalmology, Jones Eye Institute-UAMS, Little 

Rock, AR 

4582 — A0101 Isoform-specific interactions 

between human apolipoprotein E and amyloidbeta 

in the retinal pigment epithelium. Kimberly 

A. Toops, J. Xu, A. Lakkaraju. Ophthalmology 

and Visual Sciences, University of Wisconsin - 

Madison, Madison, WI 

4583 — A0102 Effects of the absence of both 

complement factor H and apolipoprotein E 

on VEGF expression, MMP2/9 activity and 

caspase-1. Laura Garcia-Garcia, P. Fernandez, S. 

Recalde, M. Moreno-Orduña, V. Fernandez-Garcia, 

A. Garcia-Layana. Ophthalmology Experimental 

Laboratory, Clinica Universidad de Navarra, 

Pamplona, Spain 

4584 — A0103 Surface plasmon resonance 

indicates that complement factor H, C3b and 

native properdin bind to carboxyethylpyrroleadducted 

BSA. Lisa Kuttner-Kondo 1 , V. P. 

Ferreira 2 , C. Cortes 2 , S. P. Yadav 3 , J. G. Hollyfield 1 . 

1 

Ophthalmic Research, Cole Eye Institute, 

Cleveland Clinic Foundation, Cleveland, OH; 

2 

Dept. of Medical Microbiology and Immunology, 

University of Toledo College of Medicine, Toledo, 

OH; 3 Molecular Biotechnology Core, Lerner 

Research Institute, Cleveland Clinic Foundation, 

Cleveland, OH 

4585 — A0104 The aging retina: Macula-less 

rat and macula-bearing monkey retinae exhibit 

common age-related changes in their retinal 

proteins. Michael R. Boehm 1, 2 , S. Mertsch 1 , H. 

Melkonyan 1 , S. Thanos 1 . 1 Institute for Experimental 

Ophthalmology, School of Medicine, WWU 

Muenster, Muenster, Germany; 2 Current Affiliation: 


Muenster Medical Center, Muenster, Germany 

4586 — A0105 Gene expression profile of 

Retinal Pigment Epithelium derived ARPE- 

19 cells under serum starvation. Sanghamitra 

Mishra 1 , K. M. Peterson 1 , A. E. Berger 2 , G. J. 

Wistow 1 . 1 Section for Molecular Structure and 

Functional Genomics, National Eye Institute, 

Bethesda, MD; 2 JHBMC Lowe Family Genomics 

Core, Johns Hopkins University - School of 

Medicine, Baltimore, MD 

4587 — A0106 HSPA5 - a possible new 

contributing gene in atrophic age-related 

macular degeneration. Sumana Chintalapudi, 

Y. H. Chan Lau, S. Sahu, M. M. Jablonski. 

Ophthalmology, The University of Tennessee 

Health Science Center, Memphis, TN *CR 

4588 — A0107 Quercetin Inhibits H2O2 

Stimulated PEDF and FGF2 Synthesis in hRPE 

Cells. Nandita Anand, P. C. Kothary, M. A. Del 

Monte. University of Michigan, Ann Arbor, MI 

4589 — A0108 AMD-like phenotypes in 

transgenic mice over-expressing BMP4 in RPE. 

Danhong Zhu 1 , J. Xu 1 , X. Deng 1 , J. Hsiung 1 , S. 

J. Ryan 2 , D. R. Hinton 1, 2 . 1 Pathology, University 

of Southern California, Los Angeles, CA; 

2 

ophthalmology, University of Southern California, 

Los Angeles, CA *CR 

4590 — A0109 Vitamin D Status and 

Subretinal Fibrosis in Neovascular Age-Related 

Macular Degeneration. Amardeep Singh 1, 2 , 

M. K. Falk 1, 2 , Y. Subhi 1, 2 , T. L. Sørensen 1, 2 . 

1 

Ophthalmology, Copenhagen University Hospital 

Roskilde, Roskilde, Denmark; 2 University of 

Copenhagen, Copenhagen, Denmark 

4591 — A0110 Cd46 -/- Mouse as a Model of 

Dry-type Age-related Macular Degeneration. 

Valeriy V. Lyzogubov 1 , X. Wu 2 , G. Kolar 2 , P. S. 

Bora 1 , J. P. Atkinson 2 , N. S. Bora 1 . 1 Ophthalmology, 

Jones Eye Institute - UAMS, Little Rock, AR; 

2 

Department of Medicine, Washington University 

School of Medicine, St. Louis, MO 

4592 — A0111 Tissue Inhibitor of 

Metalloproteinase-3 (TIMP3) Induces 

Endothelial Apoptosis via MMP- and Caspase- 

Independent Mechanisms. Jian H. Qi, B. Anand- 

Apte. Ophthalmic Research-ColeEye Inst, Cole Eye 

Institute, Cleveland, OH *CR 

4593 — A0112 Localization of 

mechanotransduction channels in the trabecular 

meshwork of glaucomatous DBA/2J mice. Phi 

Ho, V. T. Tran, L. Cabrera, S. K. Bhattacharya. 

Bascom Palmer Eye Institute, University of Miami 

Miller School of Medicine, Miami, FL 

4594 — A0113 CTRP5 over-expression in 

RPE cells leads to loss of RPE cell adhesion and 

retinal degeneration in wild-type mice. Astra 

Dinculescu 1 , S. Min 1 , W. Deng 1 , J. Li 1 , R. C. Ryals 1 , 

R. M. Stupay 1 , P. Zhu 1 , B. Sahu 2 , R. Ayyagari 2 , W. W. 

Hauswirth 1 . 1 Ophthalmology, University of Florida, 

Gainesville, FL; 2 Shiely Eye Center, University of 

California, San Diego, La Jolla, CA *CR 




437 Translational Approaches in AMD 

and DR 

Moderators: Ruth B. Caldwell and Alfred S. Lewin 

4595 — A0146 Not age but the rate of aging 

drives the pathogenesis of age related macular 

degeneration in primates. Peter Gouras 1 , L. Ivert 2 , 

M. Neuringer 3 , J. Mattison 4 . 1 Ophthalmology/Eye 

Institute, Columbia University, New York, NY; 

2 

Retina S:t Eriks Eyehospital, Karolinska institute, 

Stockholm, Sweden; 3 Ophthalmology, Oregon 

Health and Science university, Beaverton, OR; 

4 

Experimental Gerontology, National Institute on 

Aging, Baltimore, MD *CR 

4596 — A0147 The dual PPAR-α/γ agonist 

aleglitazar attenuates retinopathy in 

streptozotocin diabetic rats. Raul de la Flor 1 , 

M. B. Wright 2 , A. P. Adamis 3 , J. S. Ehrlich 3 , D. T. 

Shima 1 . 1 UCL Institute of Ophthalmology, London, 

United Kingdom; 2 Pharma Research & Early 

Development,DTA Cardiovascular & Metabolism, 

F. Hoffmann-La Roche Ltd, Basel, Switzerland; 

3 

Genentech, South San Francisco, CA *CR 


11:00 am – 12:45 pm 


299



11:00 am – 12:45 pm 

4597 — A0148 Overactive Arginase Causes 

Mitochondrial Dysfunction and Premature 

Endothelial Cell Senescence during Diabetic 

Retinopathy. Ruth B. Caldwell 1, 3 , S. Narayanan 1 , 

M. A. Rojas 1 , T. Lemtalsi 1 , Z. Xu 1 , K. Jittiporn 1 , 

E. Schenhals 1 , R. W. Caldwell 2 , D. J. Fulton 1, 2 . 

1 

Vascular Biology Center, Georgia Health 

Sciences University, Augusta, GA; 2 Department 

of Pharmacology & Toxicology, Georgia Health 

Sciences University, Augusta, GA; 3 Charlie 

Norwood VA Medical Center, Augusta, GA 

4598 — A0149 Potential beneficial effects 

of carotenoids on diabetic retinopathy. Renu 

A. Kowluru 1 , Q. Zhong 1 , J. M. Santos 1 , M. 

ThandampallayamAjje 1 , D. Putt 1 , D. L. Gierhart 2 . 

1 

Ophthalmology, Wayne State Univ/Kresge Eye 

Inst, Detroit, MI; 2 Zeavision, L.L.C, Chesterfield, 

MO *CR 

4599 — A0150 The Impact on Vision and 

Regression of Retinal Neovascularization of Anti- 

VEGF Induction in Combination with Quarterly 

Anti-VEGF Maintenance or Selective PRP versus 

Standard PRP. Victor H. Gonzalez. Valley Retina 

Institute PA, Harlingen, TX *CR, f 

4600 — A0151 Matrix metalloproteinase-9 

regulates angiogenic and vasculogenic factors 

in diabetic retina. Ghulam Mohammad, A. Abu 

El-Asrar. Ophthalmology, king Saud University, 

Riyadh, Saudi Arabia 

4601 — A0152 Subtoxic Dosage of 

Methylglyoxal Stimulated Production of 

Urokinase-Type Plasminogen Activator by 

Retinal Pigment Epithelial Cells. Anthony 

Sclafani 1 , D. Hu 1, 2 , T. Vagaggini 1 , S. A. 

McCormick 1, 2 . 1 The NY Eye & Ear Infirmary, New 

York, NY; 2 New York Medical College, Valhalla, 

NY *CR 

4602 — A0153 microRNA-30a Antagonism 

Inhibits Ras Signaling and Prevents 

Neovascularization. Carli M. Wittgrove, P. D. 

Westenskow, T. Kurihara, E. Aguilar, S. K. Moreno, 

M. Friedlander. Cell Biology, The Scripps Research 

Institute, La Jolla, CA 

4603 — A0154 Ranibizumab and Bevacizumab 

Decrease Macular Ganglion Cell Complex 

(GCC) Thickness Measured with Fourier- 

Domain Optical Coherence Tomography in Age- 

Related Macular Degeneration (AMD). Nalin 

J. Mehta 1 , H. Quiroz-Mercado 2, 3 , M. J. Sinai 6 , K. 

A. Soules 4 , A. N. Mehta 5 , S. Schwartz 2, 3 . 1 Colorado 

Retina Center, Lakewood, CO; 2 Department of 

Ophthalmology, Denver Health Medical Center, 

Denver, CO; 3 Department of Ophthalmology, 

University of Colorado, Denver, CO; 4 Optovue Inc., 

Fremont, CA; 5 Colorado Academy, Denver, CO; 

6 

formerly Optovue Inc., Fremont, CA *CR 

4604 — A0155 A new mouse model of dry 

form AMD. Haoyu Mao, A. S. Lewin, M. Conners. 

Molecular Genetics and Microbiology, University 

of Florida, Gainesville, FL *CR 

4605 — A0156 Serine/Arginine-Rich Protein 

Kinase Blockade Attenuates Choroidal 

Neovascularization. Zhenyu Dong 1, 2 , K. Noda 1, 2 , A. 

Kanda 1, 2 , J. Fukuhara 1, 2 , R. Ando 1, 2 , M. Murata 1, 2 , 

W. Saito 2 , M. Hagiwara 3 , S. Ishida 1, 2 . 1 Laboratory of 

Ocular Cell Biology and Visual Science, Hokkaido 

University Graduate School of Medicine, Sapporo, 

Japan; 2 Department of Ophthalmology, Hokkaido 


Japan; 3 Department of Anatomy and Developmental 

Biology, Kyoto University Graduate School of 

Medicine, Kyoto, Japan *CR 

4606 — A0157 Osteopontin (OPN) is Present 

in Drusen and Basal Deposits in Human Eyes 

with Age-Related Macular Degeneration (AMD). 

Amanda Bednar, M. Choudhary, P. Saloupis, A. D. 

Proia, G. Malek. Opthamology, Duke University, 

Durham, NC 

4607 — A0158 The Role of Abnormal Blood 

Flow in Age-Related Macular Degeneration. 

Luis Alarcon-Martinez 1, 2 , H. Rieiro 1 , T. Demirci 1 , 

R. Leal-Campanario 1, 3 , S. Martinez-Conde 1 , S. L. 

Macknik 1 . 1 Neurobiology, Barrow Neurological 

Institute, Phoenix, AZ; 2 Ophthalmology, 

University of Murcia, Murcia, Spain; 3 División 

de Neurociencias, Universidad Pablo de Olavide, 

Sevilla, Spain 

4608 — A0159 RPE, Bruch’s membrane 

changes in rabbit eyes and a human eye with 

retinal photoxicity. Mehmet Koray Sevinc 1 , U. 

Erdem 1 , A. Kubar 2 , E. Oztas 3 . 1 Ophthalmology, 

Gülhane Military Medical Faculty, Ankara, Turkey; 

2 

Microbiology, Gülhane Military Medical Faculty, 

Ankara, Turkey; 3 Histology, Gülhane Military 

Medical Faculty, Ankara, Turkey 

4609 — A0160 Inflammatory monocytes 

accumulate in atrophic age-related macular 

degeneration. Sophie Lavalette 1, 2 , S. Camelo 3, 4 , 

O. Levy 1, 2 , W. Raoul 1, 2 , B. Calippe 1, 2 , X. P. 

Guillonneau 1, 2 , C. Combadière 5, 6 , F. Sennlaub 1, 2 . 

1 

INSERM,U968, Paris, France; 2 UPMC Univ Paris 

06, UMR_S 968, Institut de la Vision, Paris, France; 

3 

INSERM, UMR_S 872, Centre de Recherche des 

Cordeliers, Paris, France; 4 UPMC Univ Paris 06, 

UMR_S 872, Paris, France; 5 INSERM UMR_S 

945, Laboratoire d’Immunologie Cellulaire, Paris, 

France; 6 UPMC Univ Paris 06, UMR_S 945, Paris, 

France 

4610 — A0161 Cell growth inhibtion in HPV 18 

positive uveal melanoma cells by E6/E7 siRNA. 

Xianqun Fan, R. Jia. Ninth People’s Hospital, 

Shanghai Jiaotong University School of Medicine, 


4611 — A0162 Aflibercept is internalized 

by retinal microvascular endothelial cells. 

Heidrun L. Deissler, G. E. Lang. Department of 

Ophthalmology, University of Ulm, Ulm, Germany 

*CR 

4612 — A0163 Therapeutic Efficacy of Adipose 

Stromal Cells to Protect the Retinal Neurons and 

Vasculature in Rat Retinal Ischemia-reperfusion 

Injury Model. Chandrika Abburi 1 , A. J. Cantor 1 , S. 

Caballero 5 , R. Maturi 3, 1 , T. S. Kern 4 , M. B. Grant 5 , 

K. L. March 2 , G. Rajashekhar 1, 2 . 1 Ophthalmology, 


Univ., Indianapolis, IN; 2 Indiana Center for Vascular 

Biology & Medicine, Indianapolis, IN; 3 Midwest 

Eye Institute, Indianapolis, IN; 4 Ophthalmology, 

Case Western Reserve University, Cleveland, OH; 

5 

Pharmacology and Therapeutics, University of 

Florida, Gainesville, FL *CR 

4613 — A0164 Lp-PLA 2 

is a potential 

therapeutic target in diabetic macula edema. 

Paul Canning 1 , J. V. Glenn 1 , V. Prise 1 , D. C. 

Gale 2 , A. W. Stitt 1 , P. S. Adamson 3 . 1 Centre of 

Vision & Vascular Science, Queens University 

Belfast, Belfast, United Kingdom; 2 Ophthalmology 

Discovery Performance Unit, GlaxoSmithKline, 

King of Prussia, PA; 3 Ophthalmology Discovery 

Performance Unit, GlaxoSmithKline, Stevenage, 


4614 — A0165 Differential impairment of rod 

and cone pathways in streptozotocin-induced 

diabetic mice. Ilaria Piano 1 , A. Caputo 2 , E. 

Novelli 1 , L. A. Cervetto 2 , C. M. Gargini 2 . 1 IRCCS- 

G.B. Bietti Foundation for Ophthalmology 

Research, Rome, Italy; 2 Pharmacy, University of 

Pisa, Pisa, Italy 

4615 — A0166 Comparative Ocular Tissue 

Distribution Kinetics of the Visual Cycle 

Modulator (VCM) Emixustat-HCl in Rats, 

Beagle Dogs, and Cynomolgus Monkeys. 

Terry Podoll 1 , S. Al-Fayoumi 1 , E. Prescott 2 , J. W. 

Chandler 1 , R. Kubota 1 . 1 Acucela Inc, Seattle, WA; 

2 

Covance Laboratories Inc, Madison, WI *CR 

4616 — A0167 Systemic erythropoietin and its 

role in diabetic retinopathy. Sofija Davidovic 1 , S. 

Latinovic 2 . 1 Department for vitreoretinal diseases, 

University Eye Clinic Clinical Center Vojvodina, 

Novi Sad, Serbia; 2 VIDAR ORASIS- Swiss, Private 

Eye hospital, Novi Sad, Serbia 

4617 — A0168 Chemical Screens in 

Zebrafish Identify Novel Inhibitors of Retinal 

Neovascularisation in Mouse. Breandan N. 

Kennedy 1 , Y. Alvarez 1 , M. Tosetto 2 , C. Kilty 1 , T. 

Sasore 1 , C. M. McVicar 3 , A. W. Stitt 3 , J. O’Sullivan 4 , 

A. L. Reynolds 1 . 1 UCD School of Biomolecular 

and Biomedical Science & UCD Conway Institute, 

University College Dublin, Dublin, Ireland; 2 St. 

Vincent’s University Hospital, University College 

Dublin, Dublin, Ireland; 3 Centre for Vision and 

Vascular Science, Queen’s University, Belfast, 

United Kingdom; 4 Department of Surgery, Trinity 

College Dublin, Dublin, Ireland *CR 

4618 — A0169 Evaluation of Antiangiogenic 

Effect of Sintetic Small Fragments of PEDF. 

Andrea R. Carvalho, J. Badal, M. A. Zapata, A. 

Salas Torras, L. N. Distefano, J. Garcia-Arumi. 

Ophthalmology, Inst de Recerca Hosp Vall 

d’Hebron, Barcelona, Spain 


300


4619 — A0170 A novel Erythropoietin-derived 

peptide regulates Endothelial Progenitor Cell 

(EPC) mediated retinal vasorepair. Olivia E. 

O’Leary 1 , E. Reid 1 , C. M. McVicar 1 , M. Brines 2 , A. 

Cerami 2 , R. J. Medina 1 , D. P. Brazil 1 , A. W. Stitt 1 . 

1 

Centre for Vision and Vascular Science, Queen’s 

University Belfast, Belfast, United Kingdom; 

2 

Warren Pharmaceuticals, Ossining, NY *CR 

4620 — A0171 Effect of HMG-CoA reductase 

inhibitor(statins) on the expression of catalase 

in human retinal pigment epithelial cells. Min 

Gu Kang, S. Lee, N. Kim, H. Chin. Department 

of Ophthalmology and Inha Vision Science 

Laboratory, Inha University School of Medicine, 

Incheon, Republic of Korea 

4621 — A0172 Resveratrol suppresses the 

VEGF expression by inhibition of the CXCR4 

Expression in ARPE-19 cells. Inyoung Chung 1 , H. 

Seong 2 , S. Kang 2 , J. Park 1 , S. Seo 1 . 1 Ophthalmology, 

School of Medicine, Institute of Health Sciences, 

Gyeongsang National University, Jinju-si, 

Republic of Korea; 2 Anatomy and Neurobiology, 

School of Medicine, Institute of Health Sciences, 

Medical Research Center for Neural Dysfunction, 

Gyeongsang National University, Jinju-si, Republic 

of Korea 

4622 — A0173 Antiangiogenic Effect of 

Quercetin on Laser-Induced Choroidal 

Neovascularization in Mice. Junichi Fukuhara 1, 2 , 

K. Noda 1, 2 , S. Takashina 1, 2 , Y. Dong 1, 2 , S. 

Kinoshita 1, 2 , Z. Dong 1, 2 , R. Ando 1, 2 , A. Kanda 1, 2 , 

S. Ishida 1, 2 . 1 Laboratory of Ocular Cell Biology 

and Visual Science, Hokkaido University Graduate 

School of Medicine, Sapporo, Japan; 2 Department 

of Ophthalmology, Hokkaido University Graduate 

School of Medicine, Sapporo, Japan 

4623 — A0174 Genistein Suppresses Laser- 

Induced Choroidal Neovascularization in Mice. 

Satoshi Kinoshita 1, 2 , K. Noda 1, 2 , S. Takashina 1, 2 , 

Y. Dong 1, 2 , J. Fukuhara 1, 2 , Z. Dong 1, 2 , R. Ando 1, 2 , 

A. Kanda 1, 2 , S. Ishida 1, 2 . 1 Laboratory of Ocular 

Cell Biology and Visual Science, Hokkaido 


Japan; 2 Department of Ophthalmology, Hokkaido 


Japan 

4624 — A0175 Inhibition of Laser-induced 

Choroidal Neovascularization by Macrolactin 

Compounds. Sang Jin Kim 1 , J. Kim 1 , D. Kim 2 . 

1 

Ophthalmology, Samsung Medical Center, 

Sungkyunkwan University School of Medicine, 

Seoul, Republic of Korea; 2 Research and 

Development Center, Daewoo Pharm. Co. Ltd., 

Busan, Republic of Korea *CR 

4625 — A0176 Inhibition of choroidal 

neovascularization by neutralizing PDGF with 

a recombinant fusion protein of PDGFR β 

domain. Yiwen Li 1 , W. Tao 2 , V. Ling 2 , A. Nystuen 2 , 

S. A. Elliott 2 , P. Stabila 2 , R. Wen 1 . 1 Bascom Palmer 

Eye Institute, University of Miami, Miami, FL; 

2 

Neurotech USA, Lincoln, RI *CR 

4626 — A0177 One-year Results of Intravitreal 

Ranibizumab Combined with Reduced-Fluence 

Photodynamic Therapy for Polypoidal Choroidal 

Vasculopathy. Daisuke Yamanouchi, M. Sakurai, 

T. Baba, M. Kitahashi, H. Yokouchi, M. Kubota- 

Taniai, S. Yamamoto. Chiba univercity, Chiba, Japan 

4627 — A0178 NIPAAm Based Cell Delivery 

Scaffolds for Posterior Segment Therapeutics. 

Ben Muirhead 1 , S. D. Fitzpatrick 1 , K. Gregory- 

Evans 2 , M. Bhatia 1 , H. Sheardown 1 . 1 Biomedical 

Engineering, McMaster University, Elmira, ON, 

Canada; 2 Ophthalmology and Visual Sciences, 

University of British Columbia, Vancouver, BC, 

Canada *CR 



Physiology/Pharmacology / Retinal Cell Biology 

438 Retinal Flow and VEGF 

Moderators: Michele Reibaldi and Tonia S. Rex 

4628 — B0092 Subfoveal Choroidal blood 

flow in senescence. John V. Lovasik, H. Kergoat, 

M. Parent. School of Optometry, University of 

Montreal, Montreal, QC, Canada 

4629 — B0093 Time-dependent intracellular 

pattern of Bevacizumab in RPE cells. Shereen 

Hassan M. Aboul Naga 1, 2 , M. Dithmer 1 , J. Roider 1 , 

A. K. Klettner 1 . 1 Ophthalmology, University of 

Kiel, University Medical Centre, Kiel, Germany; 

2 

Ophthalmology, Kasr Al Aini, Cairo University 

Hospitals, Cairo, Egypt *CR 

4630 — B0094 Antagonism of PDGFRβ 

Inhibits Pericyte Recruitment in a Mouse Model 

of Corneal Neovascularization. Amy Jensen 1 , R. 

Cepeda 1 , M. Maker 1 , C. E. Bigelow 1 , J. Ghosh 1 , 

G. Li 1 , P. A. D’Amore 2 , G. Spohn 1 , B. D. Jaffee 1 , S. 

Azarian 1 . 1 Ophthalmology, Novartis, Cambridge, 

MA; 2 Ophthalmology, Schepens Eye Research 

Institute, Boston, MA *CR 

4631 — B0095 Dynamic retinal venous 

oscillations are changed in diabetes mellitus 

type 1. Konstantin E. Kotliar 1, 2 , I. M. Lanzl 2 , T. 

Siegmund 4 , A. Schmidt-Trucksaess 5, 3 . 1 Biomedical 

Engineering, Aachen University of Applied 

Sciences, Juelich, Germany; 2 Ophthalmology, 

Munich University of Technology, Munich, 

Germany; 3 Preventive Sports Medicine, Munich 

University of Technology, Munich, Germany; 

4 

Endocrinology and Diabetes, Bogenhausen 

Hospital, Munich, Germany; 5 Division of Sports 

Medicine, University of Basel, Basel, Switzerland 

*CR 

4632 — B0096 Parameters related to Choroidal 

thickness. Yasuki Ito 1 , K. Oiwa 1 , E. Iwata 1 , A. 

Takahashi 1 , T. Yasuma 1 , K. Kawano 1 , N. Hamajima 2 , 

H. Terasaki 1 . 1 Ophthalmology, Nagoya University 

Graduate School of Medicine, Nagoya, Japan; 

2 

Department of Preventive Medicine, Nagoya 

University Graduate School of Medicine, Nagoya, 

Japan 

4633 — B0097 Blockade of PGF/VEGFR1 

signaling significantly prevents BRB breakdown, 

apoptosis and inflammation in diabetic 

retinopathy. Hu Huang, D. Johnson, D. Kim, G. A. 

Lutty. Ophthalmology, Johns Hopkins Wilmer Eye 

Inst, Baltimore, MD 


301 

4634 — B0098 Computational Model of 

Oxygen Transport in Retina and Optic Nerve. 

David Bragason 1 , E. Stefánsson 1, 2 . 1 Ophthalmology, 

Landspitali University Hospital, Reykjavik, Iceland; 

2 

Medicine, University of Iceland, Reykjavik, 

Iceland *CR 

4635 — B0099 Increased Retinal Vascular 

Tortuosity in Obstructive Sleep Apnea. Amir 

Mohsenin 1 , V. Mohsenin 2 , R. A. Adelman 1 . 

1 

Department of Ophthalmology, Yale University 

School of Med, New Haven, CT; 2 Yale Center 

for Sleep Medicine, Yale University School of 

Medicine, New Haven, CT 

4636 — B0100 Oxygen saturation in 

retinal hemorrhages. Olafur Palsson 1, 2 , S. H. 

Hardarson 1, 2 , T. S. Eliasdottir 2 , E. Stefánsson 1, 2 . 

1 

Department of Ophthalmology, Landspítali 

University Hospital, Reykjavik, Iceland; 2 University 

of Iceland, Reykjavik, Iceland *CR 

4637 — B0101 Assessment of Total Retinal 

Blood Flow under Systemic Hypercapnia 

and Hypocapnia. Ayda M. Shahidi 1 , S. R. 

Patel 1 , J. G. Flanagan 1, 3 , O. Tan 2 , D. Huang 2 , C. 

Hudson 1, 3 . 1 Ophthalmology & Vision Science, 

University Health Network, Toronto, ON, Canada; 

2 

Ophthalmology, Oregon Health and Science 

University, Portland, OR; 3 Optometry & Vision 

Science, University of Waterloo, Waterloo, ON, 

Canada *CR 

4638 — B0102 One-year results of 

Central Retinal Sensitivity in eyes treated 

with Pegaptanib for Proliferative Diabetic 

Retinopathy with extended dosing. Blanca C. 

Flores, V. H. Gonzalez, R. Diaz-Rohena. Valley 

Retina Institute, McAllen, TX *CR, f 

4639 — B0103 Persistent hyaloid vessels 

counteract insufficient retinal perfusion in the 

mouse eye. Christina Seide, M. Garcia Garrido, 

V. Sothilingam, N. Tanimoto, S. C. Beck, M. W. 

Seeliger. Div of Ocular Neurodegeneration, Ctr for 

Ophthal Inst for Ophth Rsrch, Tuebingen, Germany 

4640 — B0104 Retinal Vessel Diameter at 

High Altitude. Gabriel Willmann 1 , A. Schatz 1 , M. 

Fischer 1, 3 , K. Schommer 2 , E. Zrenner 1 , K. Bartz- 

Schmidt 1 , F. Gekeler 1 . 1 Centre for Ophthalmology, 

University of Tübingen, Tübingen, Germany; 

2 

Department of Sports Medicine, University 

Hospital Heidelberg, Heidelberg, Germany; 

3 

Nuffield Laboratory of Ophthalmology, University 

of Oxford, Oxford, United Kingdom *CR 

4641 — B0105 Retinal and Cerebral 

Oxygenation Response to Graded Hypoxia. 

Sunni R. Patel 1 , C. Hudson 2, 3 , A. M. Shahidi 1 , 

S. Kulasekara 2 , J. Fisher 4 , J. G. Flanagan 2, 3 , W. 

Mutch 5 . 1 Ophthalmology and Vision Sciences, 

Toronto Western Hospital, Toronto, ON, Canada; 

2 

Department of Ophthalmology and Vision 

Science, University of Toronto, Toronto, ON, 

Canada; 3 School of Optometry and Vision Science, 

University of Waterloo, Toronto, ON, Canada; 

4 

School of Physiology, University of Toronto, 

Toronto, ON, Canada; 5 Perioperative Medicine 

and Anaesthesiology, University of Manitoba, 

Winnepeg, MB, Canada *CR 


11:00 am – 12:45 pm



11:00 am – 12:45 pm 

4642 — B0106 3-D Computer-Automated 

Threshold Amsler Grid to Quantify Retinal 

Deficits Before and After Standard Treatment of 

Wet Age-related Macular Degeneration. Kristie 

Lin 1 , W. Fink 2, 3 , S. Kamjoo 1 , M. Davis 1 , T. Chang 1 . 

1 

Retina Institute of California, Arcadia, CA; 

2 

Physics, Mathematics and Astronomy, California 

Institute of Technology, Pasadena, CA; 3 Biomedical 

Engineering, University of Arizona, Tuscon, AZ 

*CR, f 

4643 — B0107 Treatment of retinal capillary 

hemangioblastoma using inhibitors of the HIF 

pathway. Mridul Mukherji, D. Vavilala, P. Swami, 

V. Ponnaluri. Pharmacy - Pharmaceutical Sci, Univ 

of Missouri - Kansas City, Kansas City, MO 

4644 — B0108 Short-term Effects of Cocoa 

on Retinal Reactivity in Individuals with 

Prediabetes and Type 2 Diabetes. Mary E. Lott 1 , 

A. Johns 1 , J. Oman 1 , J. E. Slocomb 2 , M. Herr 1 , 

R. A. Gabbay 3 , D. A. Quillen 4 , K. Bettermann 2 . 

1 

Heart and Vascular Institute, Penn State Milton S 

Hershey Med Ctr, Hershey, PA; 2 Neurology, Penn 

State Milton S Hershey Med Ctr, Hershey, PA; 

3 

Endocrinology, Penn State Milton S Hershey Med 

Ctr, Hershey, PA; 4 Opthalmology, Penn State Milton 

S Hershey Med Ctr, Hershey, PA 

4645 — B0109 Altered Vascular 

Microenvironment by Bevacizumab in 

Diabetic Fibrovascular Membrane. Shintaro 

Nakao 1 , K. Ishikawa 1 , S. Yoshida 1 , R. Kohno 1 , M. 

Miyazaki 1 , H. Enaida 1 , T. Kono 2 , T. Ishibashi 1 . 

1 

Ophthalmology, Kyushu University, Fukuoka, 

Japan; 2 Ophthalmology, Fukuoka University, 

Fukuoka, Japan 

4646 — B0110 Retinal Oxygenation During 

Intravitreal Treatment for Central Retinal Vein 

Occlusion. Sindri Traustason, M. D. de La Cour, 

M. Larsen. Dept of Ophthalmology,Glostrup Univ 

Hosp, Copenhagen University, Glostrup, Denmark 

*CR, f 

4647 — B0111 Rationale for Bimonthly 

Ranibizumab and Quarterly Aflibercept. A Drug 

and Disease Assessment Model in Wet Agerelated 

Macular Degeneration. Daniele Veritti 1 , 

G. Gorni 2 , L. Perissin 3 , P. Lanzetta 1 . 1 Department of 

Ophthalmology, University of Udine, Udine, Italy; 

2 

Department of Mathematics and Computer Science, 

University of Udine, Udine, Italy; 3 Department of 

Biomedical Sciences and Technologies, University 

of Udine, Udine, Italy *CR 

4648 — B0112 Retinal Vein Occlusions in 

Young Patients: Visual Outcomes and Associated 

Systemic Risk Factors. Noureen Khan 1, 2 , M. 

M. Lai 1, 2 . 1 Dept. of Ophthalmology, Georgetown 

University/Washington Hospital Center, 

Washington, DC; 2 The Retina Group of Washington, 

Chevy Chase, MD 

4649 — B0113 Effects of Prostacyclin on 

Isolated Porcine Retinal Arterioles: Cross-Talk 

between Nitric Oxide and Prostacyclin. Shinji 

Ono, T. Nagaoka, T. Omae, T. Kamiya, A. Yoshida. 

Ophthalmology, Asahikawa Med University, 

Asahikawa, Japan *CR 

4650 — B0114 Perifoveal Microvasculature 

in Human Eyes with Vascular Comorbidities. 

Geoffrey Chan 1, 2 , C. Bala 1, 2 , P. Yu 1, 2 , W. Morgan 1 , I. 

L. McAllister 1 , S. J. Cringle 1, 2 , Y. Dao-Yi 1, 2 . 1 Centre 

for Ophthalmology and Visual Science, Perth, WA, 

Australia; 2 Australian Research Council Centre 

of Excellence in Vision Science, Canberra, ACT, 

Australia *CR 

4651 — B0115 Flavonoid-rich dark chocolate 

improves endothelial function in retinal 

vessels. Naim Terai, A. Gedenk, E. Spoerl, R. 

P. Stodtmeister. Ophthalmology, University of 

Dresden, Dresden, Germany *CR 

4652 — B0116 Inhibition of retinal 

neovascularization by luteolin via suppression 

of VEGF expression and VEGFR signaling 

pathway. Sung Wook Park 1, 2 , C. Cho 1 , H. Jun 1 , 

N. Ryu 3 , J. Kim 1 , Y. S. Yu 1 , J. Kim 3 , J. Kim 1, 2 . 

1 

FARB, Department of Ophthalmology, Seoul 

National University Hospital, Seoul, Republic 

of Korea; 2 Biomedical Sciences, Seoul National 

University College of Medicine, Seoul, Republic of 

Korea; 3 Diabetic Complications Research Center, 

Division of Traditional Korean Medicine Integrated 

Research, Korea Institute of Oriental Medicine, 

Daejeon, Republic of Korea 

4653 — B0117 Plasma VEGF-levels are 

variable in patients with persistent renal 

dysfunction and diabetes: possible implications 

and risks for ophthalmic anti-VEGF therapy. 

Markus van der Giet, M. Schuchardt, N. Pruefer, 

J. Pruefer. Med. Klinik - SP Nephrology, Charite - 

Universitätsmedizin Berlin, Berlin, Germany *CR 

4654 — B0118 Pathological retinal 

neovascularization is exacerbated by selective 

pharmacological blockade of VEGFR2, but 

ameliorated by combination with Placental 

Growth Factor (PlGF) inhibition in the Oxygen 

induced Retinopathy (OIR) model in mice. 

Eunice Cheung, I. B. Lobov, G. D. Yancopoulos, 

S. J. Wiegand. Ophthalmology, Regeneron 

Pharmaceuticals, Inc., Tarrytown, NY *CR 

4655 — B0119 Treatment of proliferative 

idiopathic macular telangiectasia Type 2 with 

intravitreal bevacizumab. Ranjit Sandhu, R. D. 

Hamilton. Medical Retina, Moorfields Eye Hospital, 


4656 — B0120 Computational model of blood 

flow through the choriocapillaris highlights 

marked heterogeneity of blood flow. Moussa A. 

Zouache 1, 2 , P. J. Luthert 1, 2 , I. Eames 3 . 1 Institute 


London, United Kingdom; 2 NIHR Biomedical 

Research Centre in Ophthalmology, London, United 

Kingdom; 3 Department of Mechanical Engineering, 

University College London, London, United 

Kingdom 

4657 — B0121 Periocular injection of a broad 

spectrum antiangiogenic therapy regresses 

choroidal neovascularization. Ofra Benny, Z. 

Chi, L. Bazinet, R. J. D’Amato. Boston Children’s 

Hospital, Harvard Medical School, Boston, MA 

*CR 

4658 — B0122 Efficacy and safety of 

subconjunctival bevacizumab for recurrent 

pterygium. Larissa S. Stival 1 , A. M. Lago 1 , M. 

N. Figueiredo 1 , R. G. Bittar 2 , M. L. Machado 1 , J. 

J. Nassaralla 2 . 1 Cornea and Refractive Surgery, 

Instituto de Olhos de Goiania, Goiania, Brazil; 

2 

Retina and Vitreous, IOG, Goiania, Brazil f 

4659 — B0123 A Treat and Extend Regimen 

Using Anti-VEGF Therapies for Central Retinal 

Vein Occlusion. Christopher J. Brady, R. Alshareef, 

A. J. Witkin, C. D. Regillo. Wills Eye Institute, 

Jefferson Univ School of Medicine, Philadelphia, 

PA *CR 

4660 — B0124 In vitro studies on the 

antiangiogenic effects of Pigment Epithelium 

Derived Factor and Somatostatin. Anna Salas 

Torras, A. R. Carvalho, I. Abasolo, M. A. Zapata, 

L. N. Distefano, S. Schwartz, J. Garcia-Arumi. 

Ophthalmology, Vall d’Hebron Research Inst, 

Barcelona, Spain 

4661 — B0125 Our experience with Sequential 

treatment of macular oedema from retinal 

vascular occlusions with anti-VEGF agents and 

Ozurdex. Evangelia Papavasileiou, A. Grixti, V. 

Kumar, S. Prasad. Eye Treatment Centre, Arrowe 

Park University Hospital, London, United Kingdom 

*CR 

4662 — B0126 Short Term Ocular Response 

of retinal blood flow to intravitreal injection 

of bevacizumab (Avastin○R) treatment in eyes 

with central retinal vein occlusion. Seung W. Lee. 

Ophthalmology, Dongguk Unv, Gyeongju Hosp, 

Gyeongju, Republic of Korea 

4663 — B0127 The Effect of Diluted Sterile 

Penetration Enhancer Solution in Nebulized Mist 

and Liquid Drop Forms on Ocular Circulation 

in Patients with Diabetic Retinopathy. Lina 

Krepste 1 , A. Harris 2 , I. Januleviciene 1 , V. J. 

Balciuniene 1 , L. Siaudvytyte 1 , R. Barsauskaite 1 , 

A. L. Gerber 2 , B. Siesky 2 . 1 Eye Clinic, Lithuanian 

University of Health Sciences, Kaunas, Lithuania; 

2 



*CR, f 

4664 — B0128 Measurement of Retinal Blood 

Flow Velocity Using a Newly Developed Doppler 

Fourier-Domain Optical Coherence Tomography 

Instruments in Humans. Akitoshi Yoshida, T. 

Nagaoka, T. Tani, E. Sato, T. Yoshioka, K. Sogawa, 

S. Nakabayashi. Ophthalmology, Asahikawa 

Medical University, Asahikawa, Japan 

4665 — B0129 Mechanisms of retinal venous 

pulsation inferred from diameter waveforms 

analysis. Fabrice Moret 1 , W. Lagreze 2 , C. M. 

Poloschek 1, 2 , M. Bach 1 . 1 Sect. Visual Function and 

Electrophys, Eye Hospital, University of Freiburg, 

Freiburg, Germany; 2 Sect. Neuroophthalmology, 

Eye Hospital, University of Freiburg, Freiburg, 

Germany *CR 

4666 — B0130 Effect of Nitric Oxide on 

Increased Retinal Blood Flow in Response to 

Flicker Stimuli in Cats. Takafumi Yoshioka, T. 

Nagaoka, A. Yoshida. Ophthalmology, Asahikawa 

Medical University, Asahikawa, Japan 


302


4667 — B0131 Measurement Of Retinal 

Blood Flow and Retinal Oxygen Tension During 

Acute Decreasing Systemic Blood Pressure In 

Cats. Tomofumi Tani, T. Nagaoka, T. Yoshioka, 

A. Yoshida. Ophthalmology, Asahikawa Medical 

University, Asahikawa, Japan 

4668 — B0132 Measurement of Retinal 

Blood Flow Using a Newly Developed Doppler 

Fourier-Domain Optical Coherence Tomography 

Instruments in Cats. Taiji Nagaoka, T. Tani, E. 

Sato, T. Yoshioka, K. Sogawa, S. Nakabayashi, 

A. Yoshida. Ophthalmology, Asahikawa Medical 

University, Asahikawa, Japan 

4669 — B0133 Development of a prototype of 

laser Doppler flowmeter for the measurement 

of blood flow of retinal vessels and optic nerve 

head tissue in small animals (rats). Marielle 

Mentek 1 , C. Chiquet 3, 1 , F. Truffer 2 , M. Bernabei 2 , B. 

Mottet 3 , J. Romanet 3 , D. Godin-Ribuot 1 , M. Geiser 2 . 

1 

INSERM U1042, Grenoble, France; 2 Institute 

of system engineering, University of Applied 

Sciences of Western Switzerland, Sion, Switzerland; 

3 

Ophthalmology department, CHU Grenoble, 

Joseph Fourier University, Grenoble, France 

4670 — B0134 Retinal blood velocity 

significantly decreased in rhegmatogenous 

retinal detachment and recovered after surgical 

treatment in both artery and vein. Hirofumi 

Kinoshita, K. Suzuma, M. Uematsu, R. Ueki, T. 

Kitaoka. Nagasaki Univ School of Medicine, 

Nagasaki, Japan 

4671 — B0135 Ocular rigidity as estimated 

based on measurement of pulse amplitude using 

pneumotonometry and fundus pulse is dependent 

on intraocular pressure. Anton B. Hommer 1, 2 , 

G. Garhofer 2 , L. Schmetterer 2 . 1 Krankenhaus 

Hera Vienna, Vienna, Austria; 2 Dep.of. Clinical 

Pharmacology, University Clinic, Vienna, Austria 

*CR 

4672 — B0136 Sphingosine 1-phosphate 

elicits constriction of isolated porcine retinal 

arterioles. Takayuki Kamiya, T. Nagaoka, T. Omae, 

S. Ono, A. Yoshida. Asahikawa Medical University, 

Asahikawa, Japan *CR 

4673 — B0137 Ocular Pulse Amplitude 

Waveform Reflects Ventricular Bigeminy 

and Aortic Insufficiency. Jean B. Kassem 1, 2 , S. 

E. Katz 1, 2 , C. J. Roberts 2, 3 , A. M. Mahmoud 2, 3 , 

R. H. Small 4, 3 , S. V. Raman 5, 3 . 1 Neuro-Orbit- 

Oculoplastics, Havener Eye Institute, Columbus, 

OH; 2 Ophthalmology, The Ohio State University, 

Columbus, OH; 3 Biomedical Engineering, The Ohio 

State University, Columbus, OH; 4 Anesthesiology, 

The Ohio State University, Columbus, OH; 

5 

Cardiovascular Medicine, The Ohio State 

University, Columbus, OH *CR 



Nanotechnology and Regenerative Medicine 

439 Ocular Nanoimaging, 

Nanobiosensors and Nanodiagnostics 

Moderators: Yolanda Diebold and Stephen H. Tsang 

4674 — B0243 Functional rescue for a full 

year after gene therapy in a pre-clinical model 

of retinitis pigmentosa. Katherine J. Wert 1, 2 , R. J. 

Davis 1 , J. Sancho-Pelluz 1 , C. Lin 1 , S. H. Tsang 1, 3 . 

1 

Ophthalmology, Columbia University, New York, 

NY; 2 Institute of Human Nutrition, Columbia 

University, New York, NY; 3 Pathology & Cell 

Biology, Columbia University, New York, NY 

4675 — B0244 The effect of nano-structural 

hydroxyapatite on the biocompatibity of artificial 

cornea skirt material in vitro and in vivo. Ying 

Dong 1, 2 , L. Wang 2 , J. Yang 3 , Y. Huang 2 , F. Cui 3 . 

1 

Department of Ophthalmology, First Hospital 

Affiliated to Chinese PLA General Hospital, 

Beijing, China; 2 Department of Ophthalmology, 

Chinese PLA General Hospital, Beijing, China; 

3 

Department of Material Science and Engineering, 

Tsinghua University, Beijing, China 

4676 — B0245 Formulation of a Biocompatible 

Photopolymerizable Gel to Prevent the 

Oxiative Damage of the Crystalline Lens. 

Tongalp H. Tezel 1, 2 , Q. Zeng 1 , M. G. O’Toole 3 , A. 

S. Gobin 3 . 1 Ophthal & Vis Sciences, University 

of Louisville, Louisville, KY; 2 Anatomy and 

Neurobiology, University of Louisville, Louisville, 

KY; 3 Bioengineering, University of Louisville, 

Louisville, KY *CR 

4677 — B0246 Efficacy of a novel 

bioengineered corneal stroma fabricated by 

a new biocompatible cross linker in corneal 

stromal disease model. Takeshi Soma 1 , M. 

Matsusaki 2 , M. Matsumoto 2 , H. Ajiro 2 , M. 

Tsujikawa 1 , R. Hayashi 1 , Y. Oie 1 , M. Akashi 2 , K. 

Nishida 1 . 1 Department of Ophthalmology, Osaka 

University Graduate School of Medicine, Suita, 

Japan; 2 Department of Applied Chemistry, Osaka 

University Graduate School of Graduate School of 

Engineering, Suita, Japan *CR 

4678 — B0247 Feasibility of 2nd Generation 

STS Retinal Prosthesis with 49 Channel 

Electrode Array in Dogs. Takashi Fujikado 1, 2 , M. 

Kamei 2 , H. Sakaguchi 2 , H. Kanda 1 , T. Morimoto 1, 2 , 

K. Nishida 2 , H. Kishima 3 , T. Maruo 3 , K. Osawa 4 , 

M. Ozawa 4 . 1 Applied Visual Science, Osaka 

University, Suita, Japan; 2 Ophthalmology, Osaka 

University, Suita, Japan; 3 Neurosurgery, Osaka 

University, Suita, Japan; 4 Vision Institute, Nidek 

Co., Gamagori, Japan *CR 

4679 — B0248 Air transport system of oral 

mucosal tissue and cell sheets for clinical 

trial. Yoshinori Oie 1 , S. Andojo 1 , N. Konno 1 , H. 

Takayanagi 2 , T. Nozaki 3 , S. Takeda 3 , T. Soma 1 , M. 

Tsujikawa 1 , K. Nishida 1 . 1 Ophthalmology, Osaka 

University, Suita, Japan; 2 Translational Research 

Center, Tohoku Univeristy, Sendai, Japan; 3 Central 

Research Laboratory, Hitachi, Tokyo, Japan *CR 

4680 — B0249 Fullerenol Protects RPE cells 

from Oxidative-stress Induced Premature 

Senescence via Activation of SIRT1. Guo-Tong 

Xu 1, 2 , C. Zhuge 1 , J. Xu 2, 3 , J. Zhang 2, 3 , G. Xu 4 , 

L. Chen 2, 3 , X. Liu 2, 3 , H. Xu 2, 3 , L. Lu 2, 3 , W. Li 5 . 

1 

Laboratory of Clinical Visual Science, Institute of 

Health Sciences, Shanghai Institutes for Biological 

Sciences, Chinese Academy of Sciences, Shanghai, 

China; 2 Ophthal, Regenerativie Med, Tongji Univ 

School of Medicine, Shanghai, China; 3 Department 

of Regenerative Medicine and Stem Cell Research 

Center, Tongji University School of Medicine, 

Shanghai, China; 4 Department of Ophthalmology, 

Second Affiliated Hospital, Suzhou University, 

Suzhou, China; 5 Department of Ophthalmology, 

Drexel University College of Medicine, 


4681 — B0250 Reconstruction of Conjunctival 

Epithelium with Goblet Cells by Collagen 

Vitrigel. Huifang Zhou 1, 2 , Q. Guo 1 , M. Grant 3 , J. 

Elisseeff 1 . 1 Translational Tissue Engineering Center, 

Wilmer Eye Institute and Biomedical Engineering, 

Baltimore, MD; 2 Ophthalmology, Shanghai 

Ninth People’s Hospital, Shanghai Jiaotong 

University School of Medicine, Shanghai, China; 

3 

Oculoplastics Division, Ocular and Orbital Trauma 

Center, Wilmer Eye Institute, Johns Hopkins School 

of Medicine, Baltimore, MD *CR 

4682 — B0251 Overall visual performance is 

well described by three independent measures 

in Argus ® II subjects. Thomas Z. Lauritzen 1 , A. 

Das 1, 2 , J. D. Dorn 1 , R. J. Greenberg 1 . 1 Second Sight 

Med Products, Inc, Sylmar, CA; 2 Dept. of Physics, 

USC, Los Angeles, CA *CR, f 

4683 — B0252 Excimer Ablation of Collagen- 

Based Corneal Substitutes. Silvia Odorcic 1 , C. 

Noel 1 , D. Mitra 1 , D. Priest 1 , S. Taylor 1 , M. Griffith 2 , 

R. Munger 1 , W. Jackson 1 . 1 The Ottawa Hospital, 

Ottawa, ON, Canada; 2 Linköping University, 

Linköping, Sweden *CR 

4684 — B0253 Human retinal progenitor cells 

as a tool for retinal repair: establishing cell lines 

for clinical study. Petr Y. Baranov 1 , G. Brooke 2 , 

S. Patel 2 , M. J. Young 1 , J. Sinden 2 . 1 Schepens Eye 

Research Institute, Boston, MA; 2 ReNeuron Ltd., 

Guildford, United Kingdom *CR 

4685 — B0254 Hybrid vitronectin-mimicking 

polycaprolactone scaffolds and human retinal 

progenitor cell composites. Elodie Lawley 1, 2 , P. Y. 

Baranov 1 , M. J. Young 1 . 1 Opthamology, Schepens 

Eye Research Institute, Massachusetts Eye and Ear, 

an affiliate of Harvard Medical School, Boston, 

MA; 2 Exeter Medical School, Exeter, United 

Kingdom *CR 

4686 — B0255 Stem Cell and Encapsulated 

Drug Delivery to the Inner Retina using a Fibrin 

Polymer Spray System. Hari Jayaram 1, 2 , M. F. 

Jones 2 , R. M. Day 3 , P. B. Cottrill 2 , K. Eastlake 2 , S. 

Becker 2 , G. Limb 2 . 1 NIHR Biomedical Research 

Centre for Ophthalmology, UCL Institute of 

Ophthalmology & Moorfields Eye Hospital NHS 

Foundation Trust, London, United Kingdom; 

2 

Ocular Biology & Therapeutics, UCL Insitute 


3 

Applied Biomedical Engineering, University 

College London, London, United Kingdom *CR 


11:00 am – 12:45 pm 


303



11:00 am – 12:45 pm 

4687 — B0256 A synthetic carrier for cultured 

corneal endothelium implantation. Mark 

Daniell 1 , K. D. Brown 1 , B. Ozcelik 4 , P. McKelvie 3 , 

H. Zhang 1 , K. Abberton 2 . 1 CERA, Melbourne, VIC, 

Australia; 2 The O’Brien Institute, Fitzroy, VIC, 

Australia; 3 Anatomical Pathology, St. Vincent’s 

Hospital, Melborne, VIC, Australia; 4 Chemical 

and Biomolecular Engineering, The University of 

Melbourne, Parkville, VIC, Australia 

4688 — B0257 Vision Restoration in Mouse 

Models of RP using Light-Gated G-Protein 

Coupled Receptors. Benjamin Gaub, M. Berry, 

J. Levitz, J. G. Flannery, E. Isacoff. UC Berkeley, 

Berkeley, CA 

4689 — B0258 Connective Tissue Growth 

Factor Protein Expression by Müller Cells is 

Bipartite as a Function of Substrate Stiffness. 

William J. Foster 1, 2 , J. T. Davis 2 . 1 Ophthalmology, 

Weill-Cornell Med Coll, Houston, TX; 2 Physics, 

The University of Houston, Houston, TX 

4690 — B0259 Corneal Stromal Bioequivalents 

Secreted on Patterned Silk Substrata by Corneal 

Fibroblasts and Stem Cells. Jian Wu 1, 2 , Y. Du 3 , J. 

Rnjak-Kovacina 4 , D. Kaplan 4 , J. L. Funderburgh 3 . 

1 

McGowan Institute for Regenerative Medicine, 

University of Pittsburgh School of Medicine, 

Pittsburgh, PA; 2 Ophthalmology & Surgery, 

University of Pittsburgh School of Medicine, 

Pittsburgh, PA; 3 Ophthalmology, University 

of Pittsburgh School of Medicine, Pittsburgh, 

PA; 4 Biomedical Engineering, Tufts University, 

Medford, MA 

4691 — B0260 Kinetics of apoptotic death 

and oxidative damage in the retina of P23H-1 

rats and the protective effects of nanoceria. 

Lily L. Wong 1 , S. Seal 3, 4 , J. F. McGinnis 1, 2 . 

1 

Ophthalmology, University of Oklahoma Health 

Sciences Center & Dean McGee Eye Institute, 

Oklahoma City, OK; 2 Cell Biology and Oklahoma 

Center for Neuroscience, University of Oklahoma 

Health Sciences Center, Oklahoma City, OK; 

3 

Advanced Materials Processing Analysis Center, 

University of Central Florida, Orlando, FL; 

4 

Mechanical Materials Aerospace Engineering, 

Nanoscience & Technology Center, University of 

Central Florida, Orlando, FL *CR 

4692 — B0261 Conversion of human amniotic 

mesenchymal cells to retinal neural-like cells in 

conditional medium. Yanqing Zhang 1 , H. Wang 2 , J. 

Qian 3 . 1 Eye and ENT Hospital of Fudan University, 

Shanghai, China; 2 Shanghai Xi Mei Aesthetic and 

Plastic Center, Shanghai, China; 3 Eye and ENT 

Hospital of Fudan University, Shanghai, China 

4693 — B0262 Regulation of Krüppel-like 

Transcription Factor (KLF’s) Family Members 

Promotes Potent Axon Regeneration in the 

Adult Rat Optic Nerve. Yan Wang 1 , A. Apara 1 , M. 

Blackmore 2 , D. P. Brown 1 , M. E. LeBlanc 3 , A. E. 

Trillo 1 , J. L. Goldberg 1 . 1 Ophthalmology, Bascom 

Palmer Eye Institute, Miami, FL; 2 Biomedical 

Science, College of health science,Marquette 

University, Milwaukee, WI; 3 PIBS, University of 

Miami, Miami, FL 

4694 — B0263 Positive charged nanoemulsion 

enhanced cyclosporine penetrate into cornea 

after ocular topical application. Junjie Zhang, 

L. Wang, T. Zhou, J. He, H. Xia, H. Zhang. Dpt 

of Pharmaceutical Science, Henan Eye Institute, 

Henan Eye Hospital, Zhengzhou, China 

4695 — B0264 Induction of cytokeratin 3 

expression in immortalized human oral mucosal 

epithelial cells by the transduction of Pax6. 

Yuzuru Sasamoto, R. Hayashi, M. Tsujikawa, 

K. Nishida. Ophthalomology, Osaka University 

Medical School, Suita, Japan *CR 

4696 — B0265 Transplantation of human 

retinal progenitor cells into the subretinal space 

of mini pigs. Caihui Jiang, X. Wang, M. Zhang. 

Ophthal-Schepens Eye Rsrch Inst, Chinese PLA 

General Hospital, Beijing, China 

4697 — B0266 Controlled Physical Properties 

of Stem Cell Scaffolds for Photoreceptor 

Regeneration. Kristan Worthington 1, 3 , A. K. 

Salem 2 , A. Guymon 1 , B. A. Tucker 3 . 1 Chemical and 

Biochemical Engineering, University of Iowa, Iowa 

City, IA; 2 Pharmaceutical Science and Translational 

Therapeutics, University of Iowa, Iowa City, IA; 

3 

Institute for Vision Research, University of Iowa, 

Iowa City, IA 

4698 — B0267 Development of a bioengineered 

3D-model of human conjunctiva. Isabel Arranz- 

Valsero 1, 2 , L. Garcia-Posadas 1, 2 , A. Fernández 3 , A. 

López-García 1, 2 , F. Iglesias 3 , Y. Diebold 1, 2 . 1 Ocular 

Surface Group, IOBA-University of Valladolid, 

Valladolid, Spain; 2 Networking Research Center on 

Bioengineering, Biomaterials and Nanomedicine 

(CIBER-BBN), Valladolid, Spain; 3 Human Tissue 

Bank, San Francisco Clinic Foundation, León, 

Spain 

4699 — B0268 Hybrid interphotoreceptor 

matrix - poly(caprolactone) scaffolds for 

human retinal progenitor cell culture and 

differentiation. Michael J. Young 1 , A. Michaelson 2 , 

P. Y. Baranov 1 , R. L. Carrier 2 . 1 Schepens Eye 

Research Inst, Massachusetts Eye and Ear, Harvard 

Medical School, Boston, MA; 2 Northeastern 

University, Boston, MA *CR 

4700 — B0269 Differentiation Of Induced 

Pluripotent Stem Cells-Derived Neural Crest 

Cells Into Corneal Keratocytes In Vivo. 

Satoru Yoshida 1 , H. Miyashita 1 , M. Yasuda 1 , E. 

Inagaki 1 , K. Tsubota 1 , H. Okano 2 , S. Shimmura 1 . 

1 

Ophthalmology, Keio University School of 

Medicine, Tokyo, Japan; 2 Physiology, Keio 

University School of Medicine, Tokyo, Japan *CR 

4701 — B0270 Nanoparticle polyethylenimine- 

BMP7 Transfection Dose, Anti-fibrotic Efficacy 

and Toxicity for the Rabbit Cornea. Chaitasi 

Naik 1 , J. T. Rodier 1 , A. Sharma 1 , A. Stallard 1 , A. 

Tandon 1 , A. Klibanov 2 , R. R. Mohan 1 . 1 University 

of Missouri - Columbia/Mason Eye Institue, 

Columbia, MO; 2 Massachusetts Institute of 

Technology, Cambridge, MA 

4702 — B0271 Myopia control in guinea 

pigs with a biomimetic hyaluronic acidbased 

hydrogel. Mariana Garcia 1 , A. K. Jha 2 , 

K. E. Healy 2 , C. F. Wildsoet 1 . 1 Vision Science, 

University of California, Berkeley, Berkeley, CA; 

2 

Bioengineering, University of California, Berkeley, 

Berkeley, CA 

4703 — B0272 Development of an Amniotic 

Membrane-Based Cell Scaffold Using Super 

Critical CO2 Technology. David O. Zamora 1 , J. 

L. Wehmeyer 2 , H. H. Wang 1 , R. J. Christy 2 , A. J. 

Johnson 1 . 1 Ocular Trauma, U.S. Army Institute 

of Surgical Research, Ft. Sam Houston, TX; 

2 

Extremity Trauma & Regenerative Medicine, 

U.S. Army Institute of Surgical Research, Ft. Sam 

Houston, TX 

4704 — B0273 pRNA Nanoparticles for 

Intraviteal Delivery of siRNA in Mouse Retina. 

Dung V. Nguyen 1 , S. Caballero 1 , S. W. Matthews 2 , 

J. W. Verlander 2 , M. E. Boulton 3 , P. Guo 4 , M. B. 

Grant 1 . 1 Pharmacology & Therapeutics, University 

of Florida, Gainesville, FL; 2 Medicine, University 

of Florida, Gainesville, FL; 3 Anatomy and Cell 

Biology, University of Florida, Gainesville, FL; 

4 

Pharmaceutical Sciences, University of Kentucky, 

Lexington, KY *CR 





440 Strabismus: Treatment Methods 

Moderator: Howard S. Ying 

4705 — B0274 A comparison of inferior and 

medial rectus weakening by the faden procedure. 

Karen E. Grove 1, 2 , D. Morrison 2 . 1 Ophthalmology, 

Meharry Medical College, Nashville, TN; 

2 

Ophthalmology, Vanderbilt University, Nashville, 

TN *CR 

4706 — B0275 Infection Following Strabismus 

Surgery; Why Does it Occur and and How 

to Prevent it? Donny Suh. Ophthalmology 

Department, University of Nebraska, West Des 

Moines, IA 

4707 — B0276 The role of eye axial length 

in planning strabismus surgery. Maria Silvana 

Galantuomo, M. Fossarello, A. Cuccu, I. Zucca. 

Ophthalmology, University of Cagliari, Cagliari, 

Italy 

4708 — B0277 A modified transposition 

technique of the superior and inferior rectus 

muscles in cases with longstanding sixth nerve 

palsy to reduce postoperative vertical deviation 

and torsion. Ahmed Z. Soliman, A. Decanini, E. D. 

Bothun. Ophthalmology, University of Minnesota, 

Minneapolis, MN 

4709 — B0278 Comparison of Inferior Oblique 

Myectomy and Anterior Transposition on 

Horizontal Deviation. Tariq S. Alshehri, H. Park. 

Wilmer Eye Institute, Baltimore, MD 


304


4710 — B0279 Combined Resect and Recess 

of a Single Rectus Muscle for incomitant 

strabismus: review of 10 patients with emphasis 

on surgical dosage. Vivek Patel 1 , S. Das 2 . 

1 

University of Ottawa, Ottawa, ON, Canada; 2 Eye 

institute, University of Ottawa, Ottawa, ON, Canada 

4711 — B0280 Adjustable-suture strabismus 

surgery: A new, removable, sliding noose. Emily 

Deschler, K. Irsch, K. Guyton, D. L. Guyton. 

Division of Pediatric Ophthalmology & Adult 

StrabismusOphthalmology, The Wilmer Eye 

Institute, The Johns Hopkins School of Medicine, 


4712 — B0281 Medial Rectus Pulley Posterior 

Fixation for Divergence excess Intermittent 

Exotropia with high AC/A Ratio. Jae Ho Jung 1 , 

H. Choi 2 , J. Lee 1 , S. Cho 1 , J. E. Lee 2 , I. Byon 2 . 

1 

Ophthalmology, Pusan Nat’l Univ Yangsan 

Hospital, Yangsan, Republic of Korea; 2 PNUH, 

Busan, Republic of Korea 

4713 — B0282 Effect of inferior oblique 

weakening surgery on ocular torsion in 

congenital superior oblique palsy. Jinho Lee 1 , 

S. Suh 1, 2 , H. Choung 1, 3 , S. Kim 1, 2 . 1 Department of 

Ophthalmology, Seounl National University College 

of Medicine, Seoul, Republic of Korea; 2 Seoul 

Artificial Eye Center, Seounl National University 

Hospital Clinical Research Institute, Seoul, 

Republic of Korea; 3 Department of Ophthalmology, 

Seoul Municipal Government-Seoul National 

University Boramae Medical Center, Seoul, 


4714 — B0283 Superior oblique paralysis: 

treatment by the botulinum toxin A compared 

to surgical treatment. Abdulaziz Aloreany 1 , F. 

Farguette 1 , R. Bordas 1 , G. Saulnier 1 , H. Dalens 1 , 

F. Chiambaretta 1 , H. Nezzar 1, 2 . 1 ophthalmology, 

CHU Clermont Ferrand, Clermont ferrand, 

France; 2 IGCNC EA 3295, Université d’Auvergne, 

Clermont Ferrand, France 

4715 — B0284 Correction of accommodative 

factor in patients with residual esotropia after 

treatment with botulinum toxin for infantile 

esotropia. Mario I. Torres Garcia, R. A. Martinez, 

M. Acosta Silva, M. A. Najera Covarrubias, K. 

Calderon Soto. Estrabismo, Hospital Fundacion 

Nuestra Señora de la Luz, Distrito Federal, Mexico 

4716 — B0285 The Effect of a Temperature- 

Sensitive Poloxamer/Alginate/CaCl2 Mixture 

After Strabismus Surgery in a Rabbit Model. 

Won Yeol Ryu, H. Jung, Y. Kwon, W. C. Park, H. 

Ahn. Department of Ophthalmology, Dong-A 

University College of Medicine, Busan, Republic 

of Korea 

4717 — B0286 Can Tropicamide 1% 

Ophthalmic Solution act as a Potential Adjunct 

Treatment for Post Concussive Visual and 

Ocular Motor Symptoms? Lynn D. Greenspan. 

Foundations of Optometric Medicine, Salus 

University, Elkins Park, PA 



Cornea 

441 Corneal Development, 

Differentiation, Dystrophies, Genetics 

Moderator: Mario Matthaei 

4718 — C0101 Role of Shp2 Protein 

Phosphatase in Mouse Corneal Epithelium 

Stratification. Chia-Yang Liu 1 , G. Ng 1 , L. Yeh 2, 1 , 

H. Liu 1 , Y. Zhang 1 , W. W. Kao 1 . 1 Ophthalmology, 

Univ of Cincinnati, Cincinnati, OH; 2 Department of 

Ophthalmology, Chang-Gung Memorial Hospital, 

Linko, Taiwan 

4719 — C0102 The homeodomain transcription 

factor PITX2 is required to establish correct 

cell lineages and angiogenic privilege in the 

developing cornea. Philip J. Gage, A. L. Zacharias, 

C. Kuang. Ophthal & Vis Science, Univ Michigan- 

Kellogg Eye Ctr, Ann Arbor, MI 

4720 — C0103 Expression patterns of 

angiogenic factors correlate with vascular 

patterning of the developing anterior eye. 

Sam Kwiatkowski, R. P. Munjaal, P. Y. Lwigale. 

Biochemsitry and Cell Biology, Rice University, 

Houston, TX 

4721 — C0104 Role of Netrin-4 and Laminin 

β2 and γ3 Chains in Corneal Development and 

Maintenance. Jeremiah Martino 1, 2 , G. Bachay 1, 2 , 

M. A. Dattilo 1, 2 , D. R. Lazzaro 1, 2 , W. J. Brunken 1, 2 . 

1 

Ophthalmology and Cell Biology, SUNY 

Downstate Medical Ctr, Brooklyn, NY; 2 SUNY Eye 

Institute, Brooklyn, NY 

4722 — C0105 Ocular Manifestations of 

X-linked Reticulate Pigmentary Disorder. Kruti 

Dajee, H. D. Cavanagh, N. Hogan, L. A. Baker, A. 

R. Zinn, V. V. Mootha. Ophthalmology, University 

of Texas Southwestern Medical Center, Dallas, TX 

*CR 

4723 — C0106 Novel CHRLD1 Mutation and 

Secondary Glaucoma in Patient with X-Linked 

Megalocornea. Xin Gong, J. T. Whitson, V. V. 

Mootha. Ophthalmology, UT Southwestern Medical 

Center, Dallas, TX *CR 

4724 — C0107 An intronic TCF4 tri-nucleotide 

repeat expansion associated with Fuchs Corneal 

Dystrophy. S. Amer Riazuddin 1 , B. C. Gapsis 1 , N. 

Katsanis 2 , J. D. Gottsch 1 . 1 The Wilmer Eye Institute, 

Johns Hopkins Univ Sch of Med, Baltimore, 

MD; 2 Center for Human Disease Modeling, Duke 

University Medical Center, Durham, NC 

4725 — C0108 An Investigation of 

Mitochondrial Haplogroups in Fuchs 

Endothelial Corneal Dystrophy. Yi-Ju Li 1, 2 , M. A. 

Minear 2 , J. Rimmler 2 , E. Balajonda 3 , M. A. Hauser 2 , 

R. Allingham 3 , G. K. Klintworth 3, 4 , S. G. Gregory 2 , 

N. A. Afshari 5, 3 . 1 Biostatistics and Bioinformatics, 


2 

Center for Human Genetics, Medicine, Duke 

University Medical Center, Durham, NC; 3 Duke 

University Eye Center, Duke University Medical 

Center, Durham, NC; 4 Pathology, Duke University 

Medical Center, Durham, NC; 5 Shiley Eye Center, 

University of California San Diego, San Diego, CA 

*CR 

4726 — C0109 Impaired mitochondrial 

membrane potential in Fuchs endothelial corneal 

dystrophy. Cecily E. Hamill 1, 2 , T. Schmedt 1, 2 , Y. 

Chen 1, 2 , U. V. Jurkunas 1, 2 . 1 Massachusetts Eye 

and Ear Infirmary, Boston, MA; 2 Schepens Eye 

Research Institute, Boston, MA *CR 

4727 — C0110 Abnormal extracellular matrix 

production in corneal endothelial cells from 

patients with late-onset Fuchs corneal dystrophy. 

Julia M. Wessel, M. Zenkel, U. Schlotzer- 

Schrehardt, B. O. Bachmann, T. Tourtas, F. E. 

Kruse. Department of Ophthalmology, University of 

Erlangen-Nuremberg, Erlangen, Germany 

4728 — C0111 Three novel mutations in 

COL8A2 gene of Korean patients with Fuchs’ 

endothelial corneal dystrophy. Kyu-yeon 

Hwang 1, 2 , J. Mok 2 , C. Rho 3, 2 , C. Joo 1, 2 . 1 Department 

of Ophthalmology & Visual Science, Seoul 

St.Mary`s hospital, the catholic university of Korea, 

Seoul, Republic of Korea; 2 Catholic Institutes 

of Visual Science, The Catholic University of 

Korea, Seoul, Republic of Korea; 3 Department 

of Ophthalmology & Visual Science, Deajeon St. 

Mary`s hospital, The Catholic University of Korea, 

Dae-jeon, Republic of Korea 

4729 — C0112 Posterior Polymorphous 

Corneal Dystrophy 3 Associated with Agenesis 

of the Corpus Callosum. Michelle Jang, A. N. 

Roldan, R. F. Frausto, A. J. Aldave. Doris Stein, 

Cornea Division, Jules Stein Eye Institute, UCLA, 

Los Angeles, CA *CR 

4730 — C0113 Posterior Polymorphous 

Corneal Dystrophy is Associated with Steep 

Corneal Curvature. Lydia Ann, R. F. Frausto, 

F. Yu, C. K. Nguyen, A. J. Aldave. Jules Stein Eye 

Institute (UCLA), Los Angeles, CA *CR 

4731 — C0114 Identification of Genetic 

Variant Candidates for Posterior Polymorphous 

Corneal Dystrophy 1 utilizing Next-Generation 

Sequencing. Ricardo F. Frausto, J. Han, A. J. 

Aldave. Doris Stein, Cornea Division, Jules Stein 

Eye Institute, UCLA, Los Angeles, CA *CR 

4732 — C0115 Exclusion of Pathogenic 

Promoter Region Variants and Identification of 

Novel Nonsense Mutations in ZEB1 in Posterior 

Polymorphous Corneal Dystrophy. Pejman 

Bakhtiari, R. F. Frausto, A. N. Roldan, C. Wang, 

A. J. Aldave. Jules Stein Eye Institue, Los Angeles, 

CA *CR 


11:00 am – 12:45 pm 


305



11:00 am – 12:45 pm 

4733 — C0116 Identification by whole-exome 

next-generation sequencing of coding region 

mutations as candidates for posterior amorphous 

corneal dystrophy. Jonathan Han, R. F. Frausto, 

M. J. Kim, A. J. Aldave. Doris Stein, Cornea 

Division, Jules Stein Eye Institute, Los Angeles, 

CA *CR 

4734 — C0117 Lattice corneal dystrophy, 

type 1 (LCD1): an epithelial or stromal entity ? 

Walter Lisch 1 , B. Seitz 2 . 1 Ophthalmology, Johannes 

Gutenberg University Mainz, Mainz, Germany; 

2 

Ophthalmology, Saarland University, Homburg/ 

Saar, Germany 

4735 — C0118 Proteolytic processing in lattice 

corneal dystrophy. Ebbe Toftgaard Poulsen 1 , K. 

Runager 1 , M. W. Risør 1 , I. Thøgersen 1 , T. Dyrlund 1 , 

L. R. Thomsen 1 , G. K. Klintworth 2 , J. J. Enghild 1 . 

1 

Department of Molecular Biology, Aarhus 

University, Aarhus C, Denmark; 2 Departments of 

Pathology and Ophthalmology, Duke University, 

Durham, NC 

4736 — C0119 Benzalkonium chloride 

accelerates amyloid fibril formation in corneal 

dystrophies in vitro. Yuichi Kaji 1, 2 , H. Yagi 2 , 

Y. Kato 2 , Y. Goto 2 , T. Oshika 1 . 1 Ophthalmology, 

University of Tsukuba, Ibaraki, Japan; 2 Laboratory 

of Protein Folding, Institute for Protein Research 

Osaka University, Osaka, Japan 

4737 — C0120 Exploring the mechanism 

underlying the protein aggregation in stromal 

corneal dystrophies caused by amyloidogenic 

and non-amyloidogenic mutants of TGFBIp. 

Elavazhagan Murugan 1 , R. Lakshminarayanan 1 , R. 

W. Beuerman 1, 2 , S. S. Chaurasia 1 , J. S. Mehta 1, 2 . 

1 

Tissue engineering and stem cell research group, 


Singapore; 2 Singapore National Eye Centre, 

Singapore National Eye Centre, Singapore, 

Singapore *CR 

4738 — C0121 Insights into the molecular 

mechanisms of TGFBIp aggregation in corneal 

dystrophies. Kasper Runager 1, 2 , J. Underhaug 1 , C. 

S. Sørensen 1, 2 , H. Karring 3 , G. K. Klintworth 4 , N. 

C. Nielsen 1 , J. J. Enghild 2, 1 . 1 Center for Insoluble 

Protein Structures, Aarhus University, Aarhus, 

Denmark; 2 Department of Molecular Biology and 

Genetics, Aarhus University, Aarhus, Denmark; 

3 

Institute of Chemical Engineering, University 

of Southern Denmark, Odense M, Denmark; 

4 

Departments of Pathology and Ophthalmology, 

Duke University Medical Center, Durham, NC 

4739 — C0122 An inducible transgenic 

mouse model of TGFBI-related corneal stromal 

dystrophy. Andrew J. Huang 1 , C. Liu 2 , Y. Zhang 2 , 

H. Liu 2 . 1 Ophthalmology & Visual Sciences, 

Washington Univ School of Med, St Louis, 

MO; 2 Ophthalmology, University of Cincinnati, 

Cincinnati, OH 

4740 — C0123 Identification of TGFBI gene 

mutations in Polish patients with corneal 

dystrophies. Monika Udziela 1 , M. Oldak 2, 1 , J. 

P. Szaflik 1 , A. Federowicz 2 , R. B. Maksym 2 , R. 

Ploski 3 , J. Szaflik 1 . 1 Department of Ophthalmology, 

Medical University of Warsaw, Warsaw, Poland; 

2 

Department of Histology and Embryology, 

Medical University of Warsaw, Warsaw, Poland; 

3 

Department of Medical Genetics, Medical 

University of Warsaw, Warsaw, Poland 

4741 — C0124 The degree of exacerbated 

interfacial opacity after LASIK in Granular 

Corneal Dystrophy type 2 is related with the 

width of area of granular deposits made before 

procedure. Eung Kweon Kim, T. Rim, H. Kim, 

T. Kim. Ophthalmology, Yonsei Univ College of 

Medicine, Seoul, Republic of Korea 

4742 — C0125 shRNA Gene-silencing Therapy 

for Congenital Stromal Corneal Dystrophy. Rajiv 

R. Mohan, A. Sharma, J. T. Rodier, A. Tandon, D. E. 

Birk. Mason Eye Institute, University of Missouri- 

Columbia, Columbia, MO 



Glaucoma 

442 Surgery and Wound Healing 

Moderator: Tina Wong 

4743 — D0127 Prospective evaluation of 

medical therapy to prevent the hypertensive 

phase following implantation of a glaucoma 

drainage device. Helen L. Kornmann, A. Kwong, J. 

A. Giaconi, J. Caprioli, S. K. Law. Ophthalmology, 

Jules Stein Eye Institute, Los Angeles, CA *CR, f 

4744 — D0128 High Intensity Focused 

Ultrasound (HIFU) in patients with Refractory 

Glaucoma. Shlomo Melamed, M. Goldenfeld, D. 

Cotlear, A. Skaat. Goldschleger Eye Institute, Sheba 

Medical Center, Ramat Gan, Israel *CR, f 

4745 — D0129 Ahmed Glaucoma Valve versus 

Gold Micro Shunt (GMS) implants - Five years 

Results of a Prospective Randomized Clinical 

Trial. Iris Moroz, S. Melamed, O. Sagiv, G. J. Ben 

Simon, M. Goldenfeld, A. Skaat. Goldschleger Eye 

Institute, Tel Hashomer, Israel *CR, f 

4746 — D0130 Graft-free Ahmed valve 

implantation through a 6mm scleral tunnel. 

Kailun Jiang 1 , G. Gdih 2 . 1 The Ottawa Hospital, 

Ottawa, ON, Canada; 2 University of Manitoba, 

Winnipeg, MB, Canada 

4747 — D0131 The PLGA implant as an 

antimitotic delivery system after experimental 

trabeculectomy. Ignacio Rodriguez-Agirretxe 1, 2 , 

S. Vega 3 , E. Vecino 4 , J. Mendicute 2 , F. Eder 2 , T. 

M. Suarez-Cortes 3 , A. Acera 3 . 1 Glaucoma, ICQO, 

Bilbao, Spain; 2 Glaucoma, Donostia Hospital, 

San Sebastian, Spain; 3 Bioftalmik SL, Derio, 

Spain; 4 Cellular Biology, University of the Basque 

Country, Leioa, Spain *CR 

4748 — D0132 Corneal Endothelial Cells 

Loss After Trabeculectomy For Glaucoma. 

Juan A. Dios 1, 2 , M. E. Delgado 2 , V. V. Castro 3 . 

1 

Ophthalmology, Clinica Ricardo Palma, Lima, 

Peru; 2 Ophthalmology, Hospital Alberto Sabogal 

Sologuren, Callao, Peru; 3 Ophthalmology, Hospital 

Nacional Arzobispo Loayza, Lima, Peru 

4749 — D0133 Comparison of surgical 

outcomes between 360 degree catheter assisted 

and traditional 180 degree trabeculotomy in 

patients with congenital glaucoma. Monisha 

Mandalaywala Vora 1, 3 , C. H. Marcus 1, 2 , R. 

F. Rothman 1, 2 , D. D. Hayes 1, 2 , A. Angelilli 1, 2 . 

1 

Ophthalmology, North Shore Long Island Jewish 

Medical Center, Great Neck, NY; 2 Glaucoma 

Consultants of Long Island, Lake Success, NY; 

3 

Hofstra School of Medicine, Lake Success, NY 

4750 — D0134 Long term Intraocular 

Pressure Control Using Combined Endoscopic 

Cyclophotocoagulation (ECP) And 

Phacoemulsification in the Treatment of Mild to 

Moderate Glaucoma - 5 Year Results. Michael 

J. Siegel 1 , W. Boling 5 , O. S. Faridi 6 , C. K. Gupta 3 , 

M. S. Juzych 1, 2 , M. Citron 3, 4 , M. J. Siegel 3, 4 , 

L. I. Siegel 3, 4 . 1 Ophthalmology, Kresge Eye 

Institute, Detroit, MI; 2 School of Medicine, Wayne 

State University, Detroit, MI; 3 Ophthalmology, 

WIlliam Beaumont Hospital, Royal Oak, MI; 

4 

Ophthalmology, Glaucoma Center of Michigan, 

Southfield, MI; 5 Internal Medicine, Detroit 

Medical Center, Detroit, MI; 6 Ophthalmology, Eye 

Physicians & Surgeons, PC of Connecticut, Milford, 

CT 

4751 — D0135 Longitudinal Study of Corneal 

Endothelial Damage After Anterior Tube Shunt 

Surgery. Koichi Ono 1 , T. Hamanaka 2 , S. Kimura 1 . 

1 

Department of Ophthalmology, Juntendo Tokyo 

Koto Geriatric Medical Center, Juntendo University 

School of Medicine, Koto-ku, Japan; 2 Department 

of Ophthalmology, Japanese Red Cross Medical 

Center, Shibuya-ku, Japan 

4752 — D0136 Outcomes of combined 

glaucoma tube shunt and fluocinolone acetonide 

implant placement in uveitic patients compared 

to outcomes in uveitic and open angle glaucoma 

patients with glaucoma tube shunt placement 

alone. Daniel B. Moore, S. Asrani. Ophthalmology, 

Duke Eye Center, Durham, NC 

4753 — D0137 The effect of aqueous 

humour protein content and viscosity on 

equilibrium pressure under the scleral flap in 

trabeculectomies. Amir Samsudin 1, 2 , I. Eames 3 , S. 

Brocchini 2, 4 , P. T. Khaw 2 . 1 University of Malaya, 

Kuala Lumpur, Malaysia; 2 NIHR Biomedical 

Research Centre at Moorfields Eye Hospital 

NHS Foundation Trust and UCL Institute of 

Ophthalmology, London, United Kingdom; 3 UCL 

Department of Mechanical Engineering, London, 

United Kingdom; 4 UCL School of Pharmacy, 


4754 — D0138 Outcomes of Pars Plana 

Baerveldt Glaucoma Drainage Implant in Boston 

Type 1 Keratoprosthesis Surgery. Eun S. Huh, A. 

A. Aref, T. S. Vajaranant, J. De la Cruz, F. Y. Chau, 

M. S. Cortina. Ophthalmology, Univ of Illinois Eye 

& Ear Infirm, Chicago, IL *CR 


306


4755 — D0139 The Effect of Trabeculectomy 

on Astigmatism. Heleen Delbeke, I. Stalmans, E. 

Vandewalle, T. Zeyen. Ophthalmology, University 

hospitals Leuven, Leuven, Belgium f 

4756 — D0140 Initial Results of Treatment of 

Advanced Glaucoma with Ahmed Wing Valve. 

Jennifer Oakley 1 , C. Capitena 1 , D. W. Richards 1 , W. 

E. Layden 2 . 1 University of South Florida, Tampa, 

FL; 2 University Glaucoma Center, Tampa, FL 

4757 — D0141 Comparison of the outcomes 

of Trabectome with Trabeculotomy with 

deep Sclerectomy - Ab Interno vs Ab Externo 

approach. Masahiro Maeda 1, 2 , N. Kondo 2 , K. 

Onuki 2 , A. Hasegawa 3 . 1 University of California, 

Irvine, Irvine, CA; 2 Gifu Red Cross Hospital, Gifu, 

Japan; 3 Social Insurance Chukyo Hospital, Nagoya, 

Japan 

4758 — D0142 Comparison of Surgical 

Outcomes of the Ex-PRESS Glaucoma Filtration 

Device with Mitomycin C in Phakic and 

Pseudophakic Eyes. Sarwat Salim, J. Wan, H. Du. 

Ophthalmology, Hamilton Eye Institute, Memphis, 

TN *CR 

4759 — D0143 Ex-press mini-implant in the 

management of ocular hypertension secondary 

to silicon oil tamponade. Nicola Cardascia, F. 

Cantatore, P. Ferreri, F. Boscia, L. Sborgia, G. 

Alessio. Ophthalmology, Università di Bari A Moro, 

Bari, Italy 

4760 — D0144 Prospective morphological 

subconjunctive analysis by spectral domain 

optical coherence tomography of blebless 

glaucoma surgeries. J. Aritz Urcola 1, 2 , 

C. Dalmasso 1 , J. Cabrerizo 1 , A. Latorre 3 . 

1 

Ophthalmology, Hospital Universitario Araba, 

Vitoria-Gasteiz, Spain; 2 Opthalmology, Begitek 

Clínica Oftalmológica, Donostia-San Sebastián, 

Spain; 3 Research and development, Hospital 

Universitario Araba, Vitoria-Gasteiz, Spain 

4761 — D0145 Refractive outcome after 

phacoemulsification following trabeculectomy. 

Oliver L. Yeh, P. P. Chen. Ophthalmology, 

University of Washington, Seattle, WA *CR 

4762 — D0146 Long Term Outcomes 

of Filtration Surgery for Normal-Tension 

Glaucoma with Visual Field Progression at Low 

Intraocular Pressure. Scott K. Schultz, S. M. 

Iverson, W. Shi, J. C. Schiffman, D. S. Greenfield. 

Ophthalmology, Bascom Palmer Eye Institute, Palm 

Beach Gardens, FL *CR 

4763 — D0147 Corneal Endothelial Cell 

Density and Filtration Surgery in Patients with 

Posner-Schlossman Syndrome. Yuko Maruyama 1 , 

K. Mori 1 , M. Ueno 1 , Y. Ikeda 1 , K. Maruyama 2 , S. 

Kinoshita 1 . 1 Ophthalmology, Kyoto Prefectural 

Univ of Med, Kyoto, Japan; 2 Ophthalmology, 

Tohoku University Graduate School of Medicine, 

Sendai, Japan *CR 

4764 — D0148 A Comparison of Sequential 

Glaucoma Drainage Device Implantation versus 

Cyclophotocoagulation Following Failure of 

a Primary Drainage Device. Joshua Levinson, 

A. Giangiacomo, A. D. Beck, P. B. Pruett, A. 

Costarides. Ophthalmology, Emory University, 

Atlanta, GA 

4765 — D0149 Retrobulbar Shunt (RS) for 

Encapsulated Blebs. Sylvia L. Groth 1 , W. E. 

Sponsel 2 . 1 University of Minnesota Medical School, 

Minneapolis, MN; 2 University of Texas - San 

Antonio, Biomedical Engineering; WESMDPA 

Glaucoma Service, San Antonio, TX *CR 

4766 — D0150 The outcome of two different 

tube ligation methods in Baerveldt implant 

surgery. Shuri Kawamorita 1 , T. Hamanaka 1 , T. 

Sakurai 2 . 1 Japanese Red Cross Medical Center, 

Tokyo, Japan; 2 Tokyo University of Science Suwa, 

Nagano, Japan 

4767 — D0151 Tube Shunt versus 

Trabeculectomy Surgery in Patients with 

Glaucoma Associated with Ocular Inflammation. 

Cecilia S. Lee, A. Y. Lee, A. Bhorade, H. Karacal. 

Ophthalmology, Washington University in St. 

Louis, St. Louis, MO *CR 

4768 — D0152 Foreign Body Reaction in 

Glaucoma Drainage Implant Surgery. Kyoung In 

Jung, C. Park. Department of Ophthalmology and 

Visual Science, Seoul St. Mary’s Hospital,College 

of Medicine, The Catholic University of Korea, 

Seoul, Republic of Korea 

4769 — D0153 An Engineering Model for 

Predicting the Aqueous Humor Flow Rate 

through the Natural Pathway Following 

Glaucoma Surgeries. Joseph Nelly Sugu Sugira, 

M. J. Rickard. College of Engineering, California 

Baptist University, Riverside, CA 

4770 — D0154 Tube Exposures in Glaucoma 

Drainage Devices. Paramdeep S. Mand, P. P. Chen, 

M. A. Slabaugh. Ophthalmology, University of 

Washington, Seattle, WA *CR 

4771 — D0155 The Effect of Adjuvant 

Mitomycin C in Ahmed Glaucoma Valve Surgery 

For Refractory Glaucoma. Melissa Tien, L. W. Yip, 

E. Wong, V. Yong, H. Wong, B. Lim. Ophthalmology, 

National Healthcare Group Eye Institute, Tan Tock 

Seng Hospital, Singapore, Singapore f 

4772 — D0156 Repairing filtration bleb 

leakage with FocalSeal ® in rabbit model. Tatsuo 

Nagata 1 , Y. Harada 1 , H. Kondo 1 , M. Arai 2, 3 , 

A. Tawara 1 . 1 Ophthalmology, University of 

Occupational and Environmental Health, Japan, 

Fukuoka, Japan; 2 Arai Eye Clinic, Fukuoka, Japan; 

3 

Schepens Eye Research Institute, Harvard Medical 

School, Boston, MA 

4773 — D0157 Ultrasound biomicroscopy 

findings after suprachoroidal cypass implant for 

glaucoma: one year follow-up. Elisa Gonzalez 

Pastor, M. C. Bermudez, L. Morales-Fernandez, 

J. M. Martinez de la Casa, J. Garcia-Feijoo. 

Glaucoma, Hospital Clinico San Carlos, madrid, 

Spain *CR 

4774 — D0158 Complementary effects of 

bevacizumab and MMC in the improvement 

of surgical outcome after glaucoma filtration 

surgery. Tine Van Bergen 1 , K. P. Hollanders 1 , D. 

Sijnave 1 , S. Van de Velde 1 , E. Vandewalle 1 , L. K. 

Moons 2 , I. Stalmans 1 . 1 Lab of Ophthalmology, KU 

Leuven, Leuven, Belgium; 2 Department of Biology, 

Zoological Institute, KU Leuven, Leuven, Belgium 

*CR 

4775 — D0159 Ultrasonic Circular Cyclo 

Coagulation in patients with Primary Open- 

Angle Glaucoma: a Multicenter Clinical 

Trial. Florent Aptel 1 , P. Denis 2 , J. J. Rouland 3 , 

J. Nordmann 4 , Y. M. Lachkar 5 , J. G. Renard 6 , E. 

Sellem 7 , C. Baudouin 4 , A. M. Bron 8 . 1 Grenoble 

University Hospital, Grenoble, France; 2 Hôpital de 

la Croix-Rousse, Hospices Civils de Lyon, Lyon, 

France; 3 Hôpital Claude Huriez, CHRU de Lille, 

Lille, France; 4 Centre Hospitalier National des 

Quinze-Vingts, Paris, France; 5 Institut du glaucome, 

Fondation Hôpital Saint-Joseph, Paris, France; 

6 

Hôpital d’Instruction des Armées du Val de Grâce, 

Paris, France; 7 Centre Ophtalmologique Kléber, 

Lyon, France; 8 Dijon University Hospital, Dijon, 

France *CR, f 

4776 — D0160 The Effect of Early Post-op 

Anti-Hypertensive Agents on the Hypertensive 

Phase following Ahmed FP 7 Glaucoma Valve 

Implantation, a Retrospective Review. Brenton 

Finklea, A. Gupta, S. M. Johnson. Ophthalmology, 

University of Virginia, Charlottesville, VA *CR 

4777 — D0161 A comparative study of 

combined trabeculectomy with ECCE/PCIOL 

versus Ex-press Shunt with ECCE/PCIOL. 

Farvah Fatima 1, 2 , B. A. Hughes 1, 2 , R. Momi 1, 2 , 

J. Tannir 1, 2 , M. S. Juzych 1, 2 , C. Kim 1, 2 , M. H. 

Peracha 1, 2 , A. M. Eby 1, 2 , M. McQueen 1, 2 . 1 Wayne 

State University School of Medicine, Detroit, MI; 

2 

Kresge Eye Institute, Detroit, MI 

4778 — D0162 Efficacy and Safety of 

Intracameral Triesence Use in Glaucoma 

Surgery. Michael Koval, M. R. Moster, K. B. 

Freidl, M. J. Pro, J. S. Myers. Glaucoma, Wills Eye 

Institute, Philadelphia, PA *CR, f 

4779 — D0163 Acute Intra-ocular Pressure 

(IOP) Changes Following Cataract Surgery 

With and Without Trabectome Ab-interno 

Trabeculectomy. Asher Weiner 1 , Y. Weiner 2 . 

1 

Ophthalmic Consultants of the Capital Region, 

Albany, NY; 2 Undergraduate, University of 

Michigan, Ann-Arbor, MI 

4780 — D0164 Patients presenting with severe 

glaucomatous visual field defect benefit from 

both surgical and medical treatment. Eugenio 

J. Maul de la Puente, J. A. Tapia, A. Kastner. 

Ophthalmology, Universidad Catolica, Santiago, 

Chile 

4781 — D0165 Experience in the Use of 

the Express Device Without Mytomicin C in 

Patients With Primary Open Angle Glaucoma. 

Cristina G. Isida Llerandi, H. Bello Lopez Portillo, 

R. Castañeda Diez, M. García-Huerta, F. Gil 

Carrasco, J. Jimenez-Roman, M. Turati-Acosta, L. 

A. ZARATE. Glaucoma, Asociación para Evitar la 

Ceguera en México, Coyoacan, Mexico 

4782 — D0166 Investigation of the filtration 

surgery with FocalSeal ® in rabbit’s eyes. Yukinori 

Harada 1 , T. Nagata 1 , M. Arai 2, 3 , A. Tawara 1 . 

1 


Occupational & Environmental Health, Kitakyushu, 

Japan; 2 Arai Eye Clinic, Fukuoka, Japan; 3 Schepens 

Eye Research Institute, Harvard Medical School, 

Boston, MA 


11:00 am – 12:45 pm 


307



11:00 am – 12:45 pm 

4783 — D0167 Long-term results after Ahmed 

glaucoma valve implantation for different types 

of glaucoma. Olga Furashova, K. R. Pillunat, E. 

Spoerl, L. E. Pillunat. Ophthalmology, University 

Hospital, Dresden, Germany f 

4784 — D0168 Efficacy of Goniosynechialysis 

for Chronic Angle-Closure Glaucoma. Guoping 

Qing, D. Mou. Beijing Tongren Eye Center, Beijing 

Tongren Hospital, Beijing, China f 

4785 — D0169 Imaging of Surgical Blebs 

using Spectral Domain Optical Coherence 

Tomography. Giovanni Milano 1, 2 , M. Raimondi 1, 2 , 

S. Lanteri 1, 2 , S. Lombardo 1, 2 , A. Verticchio 

Vercellin 1, 2 , C. Cutolo 1, 2 , L. Bossolesi 2, 1 , G. C. 

Rossi 2, 1 . 1 University Eye Clinic, University of 

Pavia, Pavia, Italy; 2 Fondazione IRCCS Policlinico 

San Matteo, pavia, Italy *CR 

4786 — D0170 Fibrovascular ingrowth - a 

common cause of Glaucoma Drainage Device 

failure in refractory pediatric glaucoma. Irene 

Tung, I. Marcus, W. Thiamthat, E. Dosunmu, S. F. 

Freedman. Duke Eye Center, Durham, NC *CR 

4787 — D0171 Association of Aqueous 

Humor Dynamic Markers in Glaucoma With 

Canaloplasty Surgery. David M. Reed, J. L. 

Gilbert, S. E. Moroi. Ophthalmology & Visual 

Sciences, University of Michigan, Ann Arbor, MI 

*CR 

4788 — D0172 The effect of the Hydrus 

trabecular shunt on endothelial cell count: a 

double blind prospective randomized clinical 

study. Antonio M. Fea, G. Consolandi, G. Pignata, 

P. Cannizzo, M. Dal Vecchio, F. Gallozzi, C. Lavia, 

T. Rolle, F. M. Grignolo. Ophth/I Clinica Oculistica, 

Universita di Torino, Torino, Italy *CR, f 

4789 — D0173 Comparison short term post 

operative hypotony rates of 23 gauge versus 25 

gauge needle size in the formation of a corneascleral 

track for Baerveldt tube insertion into the 

anterior chamber. Kirithika Muthusamy, J. Cheng, 

K. Barton, K. Lim, L. Beltran-Agullo. Glaucoma, 

Moorfields Eye Hospital, London, United Kingdom 

*CR 

4790 — D0174 IOP-lowering and Safety 

Associated with Opening Gold Micro Shunt’s 

Windows. Nicolas Cadet, P. Harasymowycz. 

Ophthalmology, Universite de Montreal, Montreal, 

QC, Canada *CR 

4791 — D0175 Persistent hypotony associated 

to the use of immunosuppressive therapy in 

glaucoma drainage implants. Susana Duch, 

O. Stirbu, E. Milla, O. Buchacra Castellano. 

Ophthalmology- Glaucoma, Institut Condal 

d’Oftalmologia, Barcelona, Spain 

4792 — D0176 Retrospective review of 

patients with refractory glaucoma treated with 

Transcleral Diode Laser Cyclophotocoagulation. 

Vikas Tah 2 , S. Pasu 1 , S. Shah 1 . 1 Glaucoma, St Helier 

Hospital, London, United Kingdom; 2 Oxford Eye 

Hospital, Harrow, United Kingdom 

4793 — D0177 Comparison of IOP and 

postoperative complications in patients 

undergoing tube shunt or trabeculectomy 

surgery for uveitis-related intraocular pressure 

elevation. Umair Iqbal, M. Bal, R. R. Buhrmann, 

C. C. Gottlieb. University of Ottawa Eye Institute, 

Ottawa, ON, Canada *CR 

4794 — D0178 Comparison between 

Endhotelial Cell Loss After MICS Phaco 

with ExPress Implant and MICS Phaco Safe- 

Trabeculectomy. Romeo Altafini, S. Morselli. 

Ophthalmology Unit, San Bassiano Hosp, Bassano 

del Grappa, Vicenza, Italy 

4795 — D0179 The relationship between 

skin phototype and trabeculectomy outcome. 

Jonathan C. Clarke 1, 2 , M. Lee 1, 3 , A. Khalili 2 , S. 

Dhingra 1, 2 , C. Bunce 2 , P. T. Khaw 1, 2 . 1 Glaucoma 

Service, Moorfields Eye Hospital, London, United 

Kingdom; 2 NIHR Biomedical Research Centre 

for Ophthalmology, Moorfields Eye Hospital and 


Kingdom; 3 Kuala Lumpur Hospital, Kuala Lumpur, 

Malaysia *CR 

4796 — D0180 Rosmarinic Acid Suppresses 

Responses By Fibroblasts Contributing To 

Fibrosis Following Glaucoma Filtration 

Surgery. Jayter S. Paula 1 , C. Modulo 1 , M. C. 

Frade 2 , P. Reinach 1 , E. M. Rocha 1 . 1 Department 

of Ophthalmology, FMRP - USP, Ribeirao Preto, 

Brazil; 2 Internal Medicine Department, FMRP - 

USP, Ribeirao Preto, Brazil 

4797 — D0181 Incidence and success rates 

of trabeculectomy with ExPress mini shunt 

following failed canaloplasty. Jacob W. Brubaker, 

M. A. Khaimi. Ophthalmology, Dean McGee Eye 

Institute, University of Oklahoma, Oklahoma City, 

OK *CR 



Glaucoma 

443 Imaging III, GL 

Moderators: Christopher K. Leung and 

Larry Kagemann 

4798 — D0237 Glaucoma progression detection 

using a Bayesian-fuzzy logic approach applied 

to 3D spectral domain optical coherence 

tomography optic nerve head images. Akram 

Belghith, C. Bowd, R. N. Weinreb, A. J. Tatham, A. 

Miki, F. A. Medeiros, L. M. Zangwill. Department of 

Ophthalmology-0946, Hamilton Glaucoma Center, 

La Jolla, CA *CR 

4799 — D0238 Changes in Anterior Segment 

Morphology after Laser Iridotomy in Asian 

Indian Eyes: A Source Swept Anterior Segment 

Optical Tomography Study. Rajesh Sasikumar, T. 

Patil, S. A. Devi, D. Rao, R. Balu, N. K. Puttaiah, 

B. K. Shetty. Glaucoma and Research, Narayana 

Nethralaya, Bangalore, India 

4800 — D0239 Intersubject correlation 

between circumpapillary distribution of retinal 

nerve fiber layer and retinal vessels: comparison 

between optical coherence tomography and 

scanning laser polarimetry. Ivania Pereira 1 , S. 

Holzer 1 , H. Resch 1 , B. Kiss 1 , G. Fischer 2 , C. Vass 1 . 

1 

Ophthalmology & Optometry, Medical University 

Vienna, Vienna, Austria; 2 Center for Medical 

Statistics Informatics and Intelligent Systems, 

Section for Medical Information Management 

and Imaging, Medical University Vienna, Vienna, 

Austria 

4801 — D0240 Topographic Correlation 

between Ganglion Cell-Inner Plexiform Layer 

and Circumpapillary Retinal Nerve Fiber 

Layer Defect using Spectral Domain Optical 

Coherence Tomography. Ki Ho Park 1, 2 , K. Kim 1, 2 , 

J. Jeoung 1, 2 , S. Kim 1, 3 , D. Kim 1, 2 . 1 Ophthalmology, 

Seoul National University College of Medicine, 

Seoul, Republic of Korea; 2 Ophthalmology, Seoul 

National University Hospital, Seoul, Republic 

of Korea; 3 Ophthalmology, SMG-SNU Boramae 

Medical Center, Seoul, Republic of Korea 

4802 — D0241 Detecting Glaucomatous 

Structural Changes in Glaucoma Suspect Eyes 

Using a Cohort of Stable Glaucoma Patients. 

Naama Hammel 1 , L. M. Zangwill 1 , A. Miki 1 , S. Jain 2 , 

F. He 2 , N. Khachatryan 1 , J. M. Liebmann 3, 4 , C. A. 

Girkin 5 , F. A. Medeiros 1 , R. N. Weinreb 1 . 1 Hamilton 

Glaucoma Center, Department of Ophthalmology, 

University of California, San Diego, La Jolla, CA; 

2 

Department of Family and Preventive Medicine, 

University of California, San Diego, La Jolla, CA; 

3 

New York University School of Medicine, New 

York, NY; 4 Department of Ophthalmology, Einhorn 

Clinical Research Center, New York Eye and Ear 

Infirmary, New York, NY; 5 School of Medicine, 

University of Alabama, Birmingham, AL *CR, f 

4803 — D0242 Evaluation of retinal nerve fiber 

layer retardation, thickness and birefringence 

along the major nerve fiber bundles measured 

with polarization sensitive OCT. Stefan Zotter 1 , 

M. Pircher 1 , T. Torzicky 1 , B. Baumann 1 , P. K. 

Roberts 2, 1 , I. Pereira 2 , S. Holzer 2 , C. Vass 2 , U. 

Schmidt-Erfurth 2 , C. K. Hitzenberger 1 . 1 Center 

for Med. Phys. and Biomed. Eng., Medical 

University of Vienna, Vienna, Austria; 2 Department 

of Ophthalmology and Visual Sciences, Medical 

University of Vienna, Vienna, Austria *CR 

4804 — D0243 In-Vivo Microstructural 

Anatomy of Parapapillary Atrophy: Beta-Zone 

and Gamma- Zone. Yi Dai 1 , J. B. Jonas 2 , H. 

Huang 1 , M. Wang 1 , X. Sun 1 . 1 Ophthalmology, EYE 

& ENT Hospital, Shanghai, China; 2 Ophthalmology, 

Medical Faculty Mannheim of the Ruprecht-Karls- 

University, Heidelberg, Germany *CR 

4805 — D0244 Comparison of birefringencerelated 

data between scanning laser polarimetry 

(GDx) and polarization sensitive optical 

coherence tomography (PS-OCT). Clemens 

Vass 1 , I. Pereira 1 , S. Zotter 2 , S. Holzer 1 , H. 

Resch 1 , M. Pircher 2 , C. K. Hitzenberger 2 . 1 Dept 

of Ophthalmology, Medical University of Vienna, 

Vienna, Austria; 2 Center for Medical Physics and 

Biomedical Engineering, Medical University of 

Vienna, Vienna, Austria *CR 


308


4806 — D0245 Agreement between Clinical 

versus Automated Disc Damage Likelihood 

Scalw (DDLS) Staging in Asian Indian eyes. 

Premnath Gnaneswaran, S. A. Devi, R. Balu, 

D. Rao, N. K. Puttaiah, R. Shetty, R. Sasikumar. 

Glaucoma, Narayana Nethralaya, Bangalore, India 

4807 — D0246 Multiple linear regression 

analysis between circumpapillary retinal nerve 

fiber layer thickness profiles measured with 

scanning laser polarimetry and retinal blood 

vessel thickness, optic disc parameters and age. 

Hemma Resch 1 , I. Pereira 1 , S. Holzer 1 , B. Kiss 1 , G. 

Fischer 2 , C. Vass 1 . 1 Ophthalmology and Optometry, 

Medical Universitiy of Vienna, Austria, Vienna, 

Austria; 2 Center for Medical Statistics Informatics 

and Intelligent Systems, Section for Medical 

Information Management and Imaging, Medical 

Universitiy of Vienna, Austria, Vienna, Austria 

4808 — D0247 Influence of Anterior Segment 

Biometric Parameters on the Anterior Chamber 

Angle Width in Eyes with Angle Closure and 

Open Angle. Takaaki Matsuki 1, 2 , F. Hirose 1, 2 , 

T. Kameda 1, 2 , Y. Hirami 1, 2 , Y. Kurimoto 1, 2 . 

1 

Ophthalmology, Kobe City Medical Center General 

Hospital, Kobe, Japan; 2 Ophthalmology, Inst of 

Biomed Research and Innovation, Kobe, Japan *CR 

4809 — D0248 Scan quality can affect 

Scanning Laser Polarimetry outcomes. Alice 

Chandra Verticchio Vercellin 1, 2 , G. Milano 1, 2 , S. 

Lombardo 1, 2 , M. Raimondi 1, 2 , S. Lanteri 1, 2 , C. 

Cutolo 1, 2 , L. Bossolesi 2, 1 , G. C. Rossi 2, 1 . 1 University 

of Pavia, Pavia, Italy; 2 Policlinico San Matteo 

Pavia, Pavia, Italy *CR 

4810 — D0249 A New Marker for Detecting 

Retinal Ganglion Cell Apoptosis. Jacky Man 

Kwong Kwong 1 , C. Hoang 1 , R. M. Torrevillas 1 , J. 

Caprioli 1 , R. W. Yee 2 , B. D. Gray 3 , J. A. Mattis 3 , 

K. Y. Pak 3 . 1 Ophthalmology, Jules Stein Eye 

Institute, UCLA, Los Angeles, CA; 2 Cizik Eye 

Clinic, University of Texas, Health Science Center, 

Houston, TX; 3 Molecular Targeting Technologies, 

Inc., West Chester, PA *CR 

4811 — D0250 Pupil-based detection of 

asymmetric glaucomatous damage - comparison 

of the Konan RAPDx pupillograph, swinging 

flashlight method, and magnifier-assisted 

swinging flashlight method. Mohsin Ali 1, 2 , L. Lu 1 , 

P. Martinez 1 , B. M. Faria 1 , L. Gupta 1 , A. Zhang 1, 2 , 

E. Hwang 1 , M. R. Moster 1 , G. L. Spaeth 1 . 1 Glaucoma 

Service, Wills Eye Institute, Philadelphia, PA; 

2 

Jefferson Medical College, Philadelphia, PA *CR 

4812 — D0251 Effect of Laser Peripheral 

Iridotomy on Trabecular-Iris Surface Area Over 

360 Degrees in Primary Angle Closure. Donna 

Nguyen 1 , N. P. Bell 1, 2 , L. S. Blieden 1, 2 , L. A. Baker 2 , 

A. Z. Chuang 1 , R. M. Feldman 1, 2 . 1 Ophthalmology 

and Visual Science, The University of Texas Health 

Science Center at Houston, Houston, TX; 2 Robert 

Cizik Eye Clinic, Houston, TX *CR 

4813 — D0252 The Prevalence of Spectral 

Domain Optical Coherence Tomography Artifact 

Patterns in Different Subtypes of Open Angle 

Glaucoma and Normal Eyes. Neda Baniasadi, 

E. I. Paschalis, T. C. Chen. Ophthalmology, 

Massachusetts Eye & Ear Infirmary/Harvard 

Medical School, Boston, MA 

4814 — D0253 Evaluation of segmented 

macular scans by spectral domain optical 

coherence tomography in glaucoma. Maxime 

Delbarre, H. El Chehab, M. Francoz, J. Fenolland, 

M. Marie, J. Giraud, F. May, J. G. Renard. 

Department of Ophthalmology, Hopital du Val-de- 

Grâce, Paris, France 

4815 — D0254 A Novel Technology to Detect 

and Visualize Macular Retinal Nerve Fiber 

Layer (RNFL) Loss in Glaucoma Using Spectral 

Domain Optical Coherence Tomography. Laura 

de Polo 1, 2 , A. Invernizzi 1 , M. Cozzi 1 , M. Blini 1 , G. 

Staurenghi 1 . 1 Hospital Luigi Sacco, Milano, Italy; 

2 

COB,Centro Oculistico Bergamasco, Bergamo, 

Italy *CR 

4816 — D0255 In vivo imaging of lamina 

cribrosa pore and optic nerve head geometry 

in normal human eyes. Amitabha S. Bhakta, D. 

J. Marrelli, N. Sredar, K. M. Ivers, N. B. Patel, 

H. M. Queener, J. Porter. College of Optometry, 


4817 — D0256 Frequency of Abnormal Retinal 

Nerve Fiber Layer and Ganglion Cell Layer 

SDOCT Scans in Healthy Eyes and Glaucoma 

Suspects in a Prospective Longitudinal Study. 

Shawn M. Iverson 1 , M. Sehi 1 , W. J. Feuer 2 , W. 

Shi 2 , D. S. Greenfield 1 . 1 Glaucoma, University of 

Miami, Palm Beach Gardens, FL; 2 Ophthalmology, 

University of Miami, Miami, FL *CR, f 

4818 — D0257 Inner Nuclear Layer (INL) 

Cystoid Spaces (Lacunae) Observed in 

Experimental Glaucoma and Axotomy in Non- 

Human Primates (NHPs). T Michael Nork 1, 2 , 

C. A. Rasmussen 1, 2 , J. N. Ver Hoeve 1, 2 , C. J. 

Murphy 3, 2 , M. W. Neider 1, 2 , C. B. Kim 1, 2 , B. J. 

Christian 4 . 1 Ophthal & Visual Sciences, Univ 

of Wisconsin-Madison, Madison, WI; 2 Ocular 

Services On Demand (OSOD), LLC, Madison, WI; 

3 

Surgical Radiol Sci-Sch of Veterinary Medicine, 

Univ California--Davis, Davis, CA; 4 Covance, Inc, 

Madison, WI *CR 

4819 — D0258 Computational discovery of 

optic nerve head phenotypes. Mark Christopher 1 , 

L. Tang 2 , J. H. Fingert 2 , T. E. Scheetz 2, 1 , M. D. 

Abramoff 2, 3 . 1 Biomedical Engineering, University 

of Iowa, Iowa City, IA; 2 Ophthalmology and 

Visual Sciences, University of Iowa, Iowa City, IA; 

3 

Veterans Affairs, University of Iowa, Iowa City, 

IA *CR 

4820 — D0259 The Effect of Image Quality 

on the Reliability of Nerve Fiber Layer 

Measurements with Fourier-Domain OCT. Ou 

Tan 1 , X. Zhang 1 , N. A. Loewen 2 , J. S. Schuman 2 , 

D. S. Greenfield 3 , R. Varma 4 , D. Huang 1 . 

1 

Ophthalmology, Oregon Health & Science Univ, 

Portland, OR; 2 Opthalmology, University of 

Pittsburgh School of Medicine, Pittsburgh, PA; 

3 

Ophthalmology, Bascom Palmer Eye Institute, 

Miami, FL; 4 Ophthalmology, University of Southern 

California and Doheny Eye Institute, Los Angeles, 

CA *CR, f 

4821 — D0260 Combining Optical Coherence 

Topography measurements using the ‘Random 

Forest’ decision tree classifier improves the 

diagnosis of glaucoma. Koichiro Sugimoto, H. 

Murata, H. Hirasawa, C. Mayama, M. Aihara, R. 

Asaoka. Department of Ophthalmology, University 

of Tokyo Graduate School of Medicine, Tokyo, 

Japan *CR 

4822 — D0261 Comparison of Gonioscopy 

with Cirrus and Visante Optical Coherence 

Tomography (OCT) for Anterior Chamber Angle 

Assessment in Glaucoma Patients. Cindy X. Hu, 

C. Zangalli, A. Mantravadi, M. Ali, B. M. Faria, 

J. Richman, S. S. Wizov, R. Razeghinejad, M. R. 

Moster, L. Katz. Glaucoma Research, Wills Eye 

Institute, Philadelphia, PA *CR 

4823 — D0262 In Vivo Structure of the 

Schlemm’s Canal and the Collector Channels 

in Eyes with Chronic Angle-Closure Glaucoma 

Compared to Normal Eyes. Camila F. Netto 1 , 

S. Park 1, 2 , W. A. Kirkland 1 , R. L. Furlanetto 1 , Y. 

Liu 1, 3 , J. M. Liebmann 1, 4 , R. Ritch 1, 2 . 1 Moise and 

Chella Safra Advanced Ocular Imaging Laboratory, 

Einhorn Clinical Research Center, New York Eye 

and Ear Infirmary, New York, NY; 2 Department 

of Ophthalmology, New York Medical College, 

Valhalla, NY; 3 New York Medical College, Valhalla, 

NY; 4 Department of Ophthalmology, New York 

University School of Medicine, New York, NY *CR 

4824 — D0263 Stereo digital photography 

demonstrates excellent reproducibility 

with stereo slide film for the evaluation of 

glaucomatous optic disc features. Faazil Kassam 2 , 

S. Arora 1 , C. J. Rudnisky 1 , G. Douglas 2 , M. C. 

Edwards 1 , K. Verstraten 2 , B. K. Wong 3 , K. F. Damji 1 . 

1 


AB, Canada; 2 Ophthalmology, University of 

Calgary, Calgary, AB, Canada; 3 Ophthalmology, 

Loma Linda University, Loma Linda, CA *CR 

4825 — D0264 Comparison of Cirrus spectraldomain 

optical coherence tomography (OCT) 

-measured macula ganglion cell-inner plexiform 

layer (GCIPL) thickness and circumpapillary 

retinal nerve fiber layer (cpRNFL) thicknessdeviation 

maps for detection of localized retinal 

nerve fiber layer (RNFL) defects in glaucoma. Yu 

Jeong Kim 1 , M. Kim 1, 2 , K. Park 1, 2 , J. Jeoung 1, 2 , Y. 

Choi 2 , K. Kim 2 , D. Kim 1, 2 . 1 Ophthalmology, Seoul 

National University College of Medicine, Seoul, 


University Hospital, Seoul, Republic of Korea 

4826 — D0265 Does reduction in retinal nerve 

fiber layer (RNFL) birefringence precede change 

in RNFL thickness in glaucoma? Guihua Xu, Y. 

Tse, C. K. Leung. The Chinese University of Hong 

Kong, Hong Kong, China *CR 

4827 — D0266 Glaucoma Clinician (GC) 

Color Stereophoto (CSphoto) Rim Estimation 

Compared to Colocalized Spectral Domain 

Optical Coherence Tomography (SDOCT) 

Minimum Rim Measurements. Robert M. Kinast, 

R. Ren, H. Koenigsman, H. Yang, S. K. Gardiner, J. 

Reynaud, S. L. Mansberger, B. Fortune, S. Demirel, 

C. F. Burgoyne. Discoveries in Sight Research 

Laboratories, Devers Eye Institute, Legacy 

Research Institute, Portland, OR *CR 


11:00 am – 12:45 pm 


309



11:00 am – 12:45 pm 

4828 — D0267 Ability of spectral domain 

optical coherence tomography to diagnose 

preperimetric glaucoma. Chandrasekhar 

Garudadri, H. L. Rao, U. Addepalli, S. Chaudhary, 

T. Kumbar, S. Senthil. Glaucoma, L V Prasad Eye 

Institute, Hyderabad, India *CR 

4829 — D0268 A novel alignment and 

subtraction technique for the detection of 

glaucoma progression. Elizabeth D. Marlow 1, 2 , 

M. M. McGlynn 2 , N. M. Radcliffe 2 . 1 New York 

University School of Medicine, New York, NY; 

2 

Ophthalmology, Weill Cornell Medical College, 

New York, NY *CR 

4830 — D0269 Glaucoma discrimination of 

ganglion cell complex measurements with two 

SD-OCT. Marlene Francoz, H. El Chehab, J. 

Fenolland, M. Delbarre, J. Giraud, F. May, J. G. 

Renard. Military Hosp of Val-de-Grace, Paris, Paris, 

France 

4831 — D0270 Enhanced Depth Imaging 

Optical Coherence Tomography of Trabecular 

Outflow Pathway. Anum Butt 1 , S. Park 2, 3 , R. 

L. Furlanetto 2 , W. A. Kirkland 2 , C. F. Netto 2 , 

M. Al-Jumayli 2 , J. M. Liebmann 2, 4 , R. Ritch 2, 3 . 

1 

Department of Ophthalmology, The Aga Khan 

University, Karachi, Pakistan; 2 Moise and Chella 

Safra Advanced Ocular Imaging Laboratory, 

Einhorn Clinical Research Center, New York Eye 

and Ear Infirmary, New York, NY; 3 Department 

of Ophthalmology, New York Medical College, 

Valhalla, NY; 4 Department of Ophthalmology, New 

York University School of Medicine, New York, 

NY *CR 

4832 — D0271 Automated Flicker 

Chronoscopy for the Identification of 

Preperimetric Glaucomatous Progression. 

Nathan M. Radcliffe, J. R. Ehrlich, F. Q. Silva, 

Z. Syed. Ophthalmology, Weill Cornell Medical 

College, New York, NY *CR 

4833 — D0272 Developments in Optical 

Coherence Tomography Imaging in a Rat 

Model of Glaucoma. Jean-Remi Fenolland 1, 2 , 

C. Boucher 2 , M. A. Mayer 3 , W. H. Rostene 2 , C. 

Baudouin 2, 4 , A. Denoyer 2, 4 . 1 Ophthalmology, Val 

de Grace Military Hospital, Paris, France; 2 Team 

S12, Vision Institute, UPMC University Paris 6; 

UMRS968 INSERM; UMR7210 CNRS, Paris, 

France; 3 Pattern Recognition Lab, University 

of Erlangen-Nuremberg, Nuremberg, Germany; 

4 

Quinze-Vingts National Ophthalmology Hospital, 

Paris, France 

4834 — D0273 Optic disc and neuroretinal rim 

area measurements with spectral-domain optical 

coherence tomography and confocal scanning 

laser ophthalmoscopy in myopic eyes. Kunliang 

Qiu. JSIEC, Shantou, Afghanistan 

4835 — D0274 Association of vascular risk 

factors with structural glaucomatous progression 

by flicker chronoscopy. Margaret M. McGlynn, 

J. R. Ehrlich, E. D. Marlow, F. Q. Silva, N. M. 

Radcliffe. Weill Cornell Medical College, New 

York, NY *CR 

4836 — D0275 Optic nerve head analysis using 

confocal scanning laser ophthalmoscopy and 

spectral-domain optical coherence tomography. 

Gloria Roberti 1 , F. Oddone 1 , L. Tanga 1 , M. 

Michelessi 2 , D. De Geronimo 1 , M. Centofanti 1, 2 , G. 

Manni 1, 2 . 1 IRCCS Fondazione GB Bietti, Rome, 

Italy; 2 DSCMT, University of Rome Tor Vergata, 

Rome, Italy *CR 

4837 — D0276 A Tree Classification Method 

for Identifying Normal Eyes, Non-Progressing 

Glaucoma Eyes, and Progressing Glaucoma Eyes 

from Spectral Domain OCT RNFL Thickness 

Measurements. Michael H. Goldbaum, S. Yousefi, 

A. Belghith, L. M. Zangwill, F. A. Medeiros, R. N. 

Weinreb, D. Meira-Freitas, N. Hatami, C. Bowd. 

Ophthalmology, University of California at San 

Diego, La Jolla, CA *CR, f 

4838 — D0277 Utilization of Novel Technology 

to Improve Accuracy and Efficiency of Assessing 

Progression of Glaucomautous Changes in 

Serial Fundus Photos. Ozgur Ozkan 1 , R. Barnes 2 , 

B. Markowitz 1 . 1 Ophthalmology, University of 

South Carolina/Palmetto Health, Columbia, 

SC; 2 Ophthalmology, Georgetown University/ 

Washington Hospital Center, Washington, DC *CR 

4839 — D0278 Objective Assessment of 

Glaucoma Suspect Comparing Different Imaging 

Techniques. Eduardo M. Normando 1, 2 , L. A. 

Turner 1 , F. Ahmed 2 , P. A. Bloom 2 , M. Cordeiro 1, 2 . 

1 

Glaucoma & Retinal Neurodegeneration Research 

Group, Visual Neuroscience, UCL Institute of 

Ophthalmology, London, United Kingdom; 

2 

Western Eye Hospital, Imperial College Healthcare 

Trust, London, United Kingdom *CR 

4840 — D0279 Evaluation of Inner to Outer 

Retina Area Ratio for Detection of Glaucoma 

with Macular OCT Imaging. Navid Amini 1, 4 , N. 

Cirineo 1 , S. Knipping 1 , H. Hosseini 1 , J. A. Giaconi 1 , 

S. K. Law 1 , T. Chou 3 , L. A. Vese 2 , J. Caprioli 1 , 

K. Nouri-Mahdavi 1 . 1 Ophthalmology, Jules 

Stein Eye Institute at UCLA, Los Angeles, CA; 

2 

Department of Mathematics, UCLA, Los Angeles, 

CA; 3 Department of Biomathematics, UCLA, Los 

Angeles, CA; 4 UCLA Wireless Health Institute, Los 


4841 — D0280 The Magnitude and Direction of 

Mismatch between Bruch’s Membrane Opening 

(BMO) and Anterior Scleral Canal Opening 

(ASCO) within Spectral Domain Optical 

Coherence Tomography (SD-OCT) Optic Nerve 

Head (ONH) Scans of Ocular Hypertension and 

Glaucoma Patients. Christy A. Hardin, H. Yang, R. 

Ren, L. He, S. K. Gardiner, B. Fortune, S. Demirel, 

C. F. Burgoyne. Discoveries in Sight Research 

Laboratory, Devers Eye Institution and Legacy 

Research Institute, Porltand, OR *CR 

4842 — D0281 Variability of the Foveal- 

Bruch’s Membrane Opening centroid (FoBMO) 

axis angle in patients with ocular hypertension 

and early glaucoma. Luke Reyes, R. Ren, J. 

Reynaud, H. Yang, S. K. Gardiner, B. Fortune, 

S. Demirel, C. F. Burgoyne. Discoveries in Sight 

Research Laboratories, Devers Eye Institute, 

Legacy Research Institute, Portland, OR *CR 

4843 — D0282 Quadratic Bayesian Pattern 

Detection for Detecting Glaucomatous Change 

in Follow-up SD-OCT RNFL Thickness 

Measurements. Siamak Yousefi, A. Belghith, M. 

H. Goldbaum, L. M. Zangwill, F. A. Medeiros, R. 

N. Weinreb, R. Lisboa, C. Bowd. Ophthalmology, 

Hamilton Glaucoma Center, La Jolla, CA *CR, f 

4844 — D0283 A method for mapping retinal 

nerve fiber layer birefringence. Juan Reynaud, 

B. Fortune. Discoveries in Sight Research 

Laboratories, Devers Eye Institute and Legacy 

Research Institute, Portland, OR *CR 

4845 — D0284 The Prevalence of Cirrus SD- 

OCT Ganglion Cell Segmentation Errors in 

High Myopes. Tessa Johung 1 , J. D. Oakley 2 , D. 

Russakoff 2 , S. Sabhlok 1 , F. Li 3 , R. Chang 1 . 1 Stanford 

University, Stanford, CA; 2 Voxeleron, Pleasanton, 

CA; 3 Dept. of Ophthalmology and Visual Sciences, 

Chinese University of Hong Kong, Hong Kong, 

China *CR 

4846 — D0285 Optic disc morphology 

parameters in primary open angle glaucoma in 

Japanese using a stereo fundus camera - The 

Glaucoma Stereo Analysis Study (GSAS). Yu 

Yokoyama 1 , M. Tanito 2 , K. Nitta 3 , M. Katai 4 , Y. 

Kitaoka 5 , K. Omodaka 1 , S. Tsuda 1 , T. Nakagawa 6 , 

T. Nakazawa 1 . 1 Department of Ophthalmology, 

Tohoku university, Sendai-shi, Japan; 2 Department 

of Ophthalmology, Shimane University Faculty 

of Medicine, Izumo-shi, Japan; 3 Department of 

Ophthalmology, Fukui-ken Saiseikai Hospital, 

Fukui-shi, Japan; 4 Department of Ophthalmology, 

Sapporo Teishin Hospital, Sapporo-shi, Japan; 

5 

Department of Ophthalmology, St. Marianna 

University School of Medicine, Sapporo-shi, Japan; 

6 

Research & Development Section, Electronics & 

Optics Division, Kowa Company, Ltd, Nagoya-shi, 

Japan *CR 

4847 — D0286 Glaucoma Assessment using 

Retinal Topography by Scanning Laser 

Ophthalmoscope Imaging. Maarten Huijbregtse, 

D. De Brouwere, M. Mensink. i-Optics BV, The 

Hague, Netherlands *CR 

4848 — D0287 Macular Retinal Ganglion 

Cell Complex Thickness and Its Relationship 

to the Retinal Nerve Fiber Layer in Non- 

Human Primates with Ocular Hypertension. 

Kaveh Azartash, J. A. Burke. Biological Sciences, 

Allergan, Irvine, CA *CR 

4849 — D0288 Longitudinal Measurements 

In Vivo of Retinal Nerve Fiber Layer Thickness 

(RNFLT) and Retinal Ganglion Cell (RGC) 

Density after Optic Nerve Transection (ONT) 

in Rat. Tiffany E. Choe, C. J. Abbott, K. Young, 

B. Fortune. Discoveries in Sight, Devers Eye Inst, 

Legacy Health, Portland, OR *CR 


310


4850 — D0289 In Vivo Dimensions of 

Schlemm’s Canal and Number of Collector 

Channels in the Nasal and Temporal Areas of 

Normal Eyes. Wendy A. Kirkland 1 , S. Park 1, 2 , 

R. L. Furlanetto 1 , C. F. Netto 1 , Y. Liu 1, 3 , J. M. 

Liebmann 1, 4 , R. Ritch 1, 2 . 1 Moise and Chella Safra 

Advanced Ocular Imaging Laboratory, Einhorn 

Clinical Research Center, New York Eye and 

Ear Infirmary, New York, NY; 2 Department 

of Ophthalmology, Valhalla, NY; 3 New York 

Medical College, Valhalla, NY; 4 Department of 

Ophthalmology, New York University School of 

Medicine, New York, NY *CR 

4851 — D0290 The macular retinal layer 

thickness in glaucoma patients. Yoshiaki Kiuchi, 

U. Rimayanti, M. Latief. Ophthalmology & Visual 

Science, Hiroshima University, Hiroshima, Japan 

4852 — D0291 A comparison of retinal 

nerve fiber layer quadrant thickness between 

glaucomatous and glaucoma suspect eyes. Alicia 

M. Eby, R. Momi, J. Tannir, B. A. Hughes, A. Goyal, 

A. Shukairy, C. Kim, M. H. Peracha, F. Fatima, 

M. McQueen. Kresge Eye Institute, Wayne State 

University School of Medicine, Detroit, MI 



Multidisciplinary Ophthalmic Imaging 

444 Choroid and Sclera Imaging 

Moderator: Eric H. Souied 

4853 — D0292 Effect of Acoustic Radiation 

Force on the Retina, Choroid and Orbital 

Tissues. Ronald H. Silverman 1, 2 , R. Urs 1 , H. Lloyd 1 . 

1 

Ophthalmology, Columbia University Medical 

Center, New York, NY; 2 FL Lizzi Center for 

Biomedical Engineering, Riverside Research, New 

York, NY 

4854 — D0293 Analysis of the Vascular Layers 

and Morphology of the Choroid in Eyes with 

Diabetic Retinopathy using Spectral-Domain 

Optical Coherence Tomography. Erika Brewer 1, 2 , 

M. Adhi 1, 2 , N. K. Waheed 1, 2 , J. S. Duker 1, 2 . 1 New 

England Eye Center, Boston, MA; 2 Tufts University 

School of Medicine, Boston, MA *CR 

4855 — D0294 Pilot Study of the Topographic 

Correlation Between Reticular Pseudo-drusen 

and the Choroidal Vasculature Using En Face 

Optical Coherence Tomography. Jonathan Chou, 

S. D. Rollins, D. S. Grewal, S. Khan, A. A. Fawzi. 

Ophthalmology, Northwestern University, Chicago, 

IL 

4856 — D0295 Choroidal Thickness in Adult 

Onset Foveomacular Vittelliform Dystrophy and 

in Exudative Age-related Macular Degeneration. 

Florence Coscas, N. Puche, G. J. Coscas, C. 

Francais, M. Srour, G. Mimoun, G. Querques, E. 

H. Souied. Ophthalmology, University, Paris Est, 

Creteil, France *CR 

4857 — D0296 Differences in subfoveal 

choroidal thickness between acute and chronic 

central serous chorioretinopathy measured with 

enhanced depth imaging OCT. Nikolaus Feucht, 

C. Lohmann, P. Kook, C. Mayer, M. Zenk, K. M. 

Wand, M. M. Maier. Ophthalmology, Klinikum 

rechts der Isar, Technische Universität München, 

Munich, Germany *CR 

4858 — D0297 Enface Features of Chronic 

Central Serous Chorioretinopathy on Swept- 

Source Optical Coherence Tomography. Daniela 

Ferrara 1, 3 , K. J. Mohler 2 , M. Adhi 1 , J. J. Liu 2 , I. 

Grulkowski 2 , M. F. Kraus 2, 4 , N. K. Waheed 1 , C. 

R. Baumal 1 , J. G. Fujimoto 2 , J. S. Duker 1 . 1 New 

England Eye Center, Tufts University, Boston, 

MA; 2 Department of Electrical Engineering and 

Computer Science and Research Laboratory of 

Electronics, Massachusetts Institute of Technology, 

Cambridge, MA; 3 Digital Angiography Reading 

Center, New York, NY; 4 Pattern Recognition 

Lab and Graduate School in Advanced Optical 

Technologies (SAOT), 4 University Erlangen- 

Nuremburg, Erlangen, Germany *CR 

4859 — D0298 Evaluation of choroidal 

thickness in retinal vein occlusions using 

enhanced depth imaging optical coherence 

tomography. Amar P. Patel, S. S. Park. 

Ophthalmology, University of California, Davis, 

Sacramento, CA 

4860 — D0299 Diffuse choroidal thickening in 

patients with Vogt-Koyanagi-Harada Syndrome. 

Maria de las Mercedes Frick, M. Zunino, B. A. 

Schlaen, M. Lopez, E. Hurtado Jallaza, C. A. 

Couto. Ophthalmology, University of Buenos Aires, 

Buenos Aires, Argentina 

4861 — D0300 Punctate Inner Choroidopathy 

characterization by Enhanced Depth Imaging- 

Optical Coherence Tomography: Qualitative 

analysis of PIC lesions & relationship with 

clinical features. Raquel Garcia-Cabrera, J. 

Zarranz-Ventura, D. A. Sim, P. A. Keane, C. A. 

Egan, P. J. Patel, M. Westcott, R. W. Lee, A. Tufail, 

C. E. Pavesio. Moorfields Eye Hospital, London, 


4862 — D0301 The effect of scleral buckling 

surgery on choroidal thickness measured 

by enhanced depth optical coherence 

tomography. Alla Kelly, D. D. Koozekanani, 

J. Terry, S. R. Montezuma. Ophthalmology and 

Visual Neurosciences, University of Minnesota, 

Minneapolis, MN 

4863 — D0302 Quantitative measurement of 

laser-induced choroidal neovascularization with 

spectral-domain optical coherent tomography. 

Wenqiu Wang. Shanghai Key Lab of Ocular Fundus, 

Shanghai First People’s Hospital, Shanghai, China 

4864 — D0303 Peripapillary Choroidal 

Thickness Analysis with Optical Coherence 

Tomography in Unilateral Pseudoexfoliation 

Glaucoma and Pseudoexfoliation Syndrome. 

Claudia E. Bartolini, J. Zhang, M. Adhi, J. S. Duker, 

C. Krishnan. Ophthalmology, New England Eye 

Center/Tufts, Boston, MA *CR 

4865 — D0304 Enhanced Depth Imaging 

Optical Coherence Tomography of Choroidal 

Metastasis in 31 Eyes. SAAD AL-DAHMASH 1, 2 , 

C. L. Shields 2 , S. Kaliki 2 , T. V. Johnson 2 , J. 

Shields 2 . 1 King Saud University, Riyadh, Saudi 

Arabia; 2 Oncology Service, Wills Eye Institute, 


4866 — D0305 The comparison between 

subfoveal choroidal thickness measured with two 

different SD-OCT. Yuki Maekawa, K. Suzuma, E. 

Tsuiki, T. Kitaoka. Department of Ophthalmology 

& Visual Sciences, Nagasaki University Graduate 

School of Biomedical Sciences, Nagasaki, Japan 

4867 — D0306 Comparison of the Accuracy of 

Choroidal Thickness Measurements Using SD- 

OCT With and Without EDI and Swept Source 

OCT and Volumetric Analysis of the Choroid 

in Healthy Eyes. Mehreen Adhi 1, 2 , J. J. Liu 3 , A. 

H. Qavi 1 , I. Grulkowski 3 , K. J. Mohler 3 , C. D. Lu 3 , 

M. F. Kraus 3 , N. K. Waheed 1, 2 , J. G. Fujimoto 3 , 

J. S. Duker 1, 2 . 1 Ophthalmology, New England 

Eye Center, Tufts Medical Center, Boston, MA; 

2 

Ophthalmology, Tufts Univ School of Medicine, 

Boston, MA; 3 Research Laboratory of Electronics, 

Massachusetts Institute of Technology, Cambridge, 

MA *CR 

4868 — D0307 Optovue OCT as an Imaging 

Modality for Scleral Thickness. Stephanie K. 

Cramer, R. M. Beardsley, C. J. Flaxel, E. B. Suhler, 

N. S. Schubach. Ophthalmology, Casey Eye 

Institute, Portland, OR *CR 

4869 — D0308 Choroidal thickness in 

emmetropic and myopic children and adults, and 

myopic anisometropes. Andrew K. Lam, Y. Wong, 

B. S. Yu. School of Optometry, The Hong Kong 

Polytechnic University, Hong Kong, Hong Kong 

4870 — D0309 Choroidal Volume in Healthy 

Pediatric Population. Chiara Mapelli 1, 2 , 

E. Tabacchi 2 , S. Osnaghi 2 , L. Dell’Arti 1, 2 , G. 

Barteselli 1 , M. Clerici 1 , F. Viola 1, 2 , R. Ratiglia 1, 2 . 

1 

University of Milan, Milan, Italy; 2 Eye Clinic, 

Fondazione IRCCS Ca’ Granda Ospedale 

Policlinico, Milan, Italy 




445 Imaging of Animal Models 

Moderator: Mahnaz Shahidi 

4871 — D0310 Quantitative Fundus 

Autofluorescence in Mice. Correlation with 

HPLC Quantitation of RPE Lipofuscin and 

Measurement of Retina Outer Nuclear Layer 

Thickness. Janet R. Sparrow 1, 2 , A. M. Blonska 1 , 

E. Flynn 1 , T. Duncker 1 , J. P. Greenberg 1 , R. 

Secondi 1 , K. Ueda 1 , F. C. Delori 3 . 1 Department 

of Ophthalmology, Columbia University, New 

York, NY; 2 Pathology and Cell Biology, Columbia 

University, New York, NY; 3 Schepens Eye Research 

Institute, Harvard Medical School, Boston, MA 


11:00 am – 12:45 pm 


311



11:00 am – 12:45 pm 

4872 — D0311 In Vivo Imaging of hESC-RPE 

Implanted in the RCS Rat Using InfraRed 

Reflectance. Aldo A. Oregon-Miranda 1, 2 , R. 

Ribeiro 1 , W. Charafeddin 1 , B. Diniz 1 , M. J. Koss 1 , 

P. B. Thomas 1 , B. B. Thomas 1 , G. J. Chader 1 , 

D. R. Hinton 1 , M. S. Humayun 1 . 1 Doheny eye 

institute, University of Southern California, Los 

Angeles, CA; 2 Oftalmologia, Antiguo Hospital 

Civil de Guadalajara, Fray Antonio Alcalde, UDG, 

Guadalajara, Mexico *CR 

4873 — D0312 Spectral Domain Optical 

Coherence Tomography as a Measure of Axonal 

Degeneration and Protection in Experimental 

Autoimmune Encephalomyelitis. Anastasiya 

Johnson 1 , K. V. Michaels 1 , B. K. Morris 2 , A. K. 

Garg 1 , P. Chaudhary 2 , H. E. Titus 1 , M. D. Andrews 1 , 

D. Bourdette 2 , M. E. Pennesi 1 , G. H. Marracci 2 . 

1 


Institute, Portland, OR; 2 Neurology, Oregon Health 

& Science University, Portland, OR *CR 

4874 — D0313 Comparison of ocular 

parameters of Bugeye and Wild-type zebrafish 

using Optical Coherence Tomography. Pinakin G. 

Davey, D. Cameron. College of Optometry, Western 

University of Health Sciences, Pomona, CA 

4875 — D0314 Multimodal adaptive optics 

imaging system (MAOS) for small animals. Ankit 

Patel 1 , R. D. Ferguson 1 , M. Mujat 1 , N. Iftimia 1 , J. 

D. Akula 2 . 1 Biomedical Imaging Group, Physical 

Sciences Inc, Andover, MA; 2 Ophthalmology, 

Children’s Hospital Boston, Boston, MA *CR 

4876 — D0315 Assessment of Vascular 

Integrity and Leukocyte Endothelial Interaction 

in the Murine Retina After Ionizing Radiation 

by in vivo retinal imaging. Clemens Alt, J. M. 

Runnels, G. Teo, C. P. Lin. Wellman Center for 

Photomedicine, Massachusetts General Hospital, 

Boston, MA 

4877 — D0316 Fluorescence lifetime imaging in 

mouse models. Chantal Dysli, V. Enzmann, S. Wolf, 

M. S. Zinkernagel. University of Bern, Department 

of Ophthalmology, Bern, Switzerland *CR 

4878 — D0317 Density and distribution of 

NG2+ pericytes in the living mouse retina. 

HoanVu Nguyen 1 , D. R. Williams 2, 3 , J. B. Schallek 2 . 

1 

Department of Biological Sciences, University of 

Denver, Denver, CO; 2 Center for Visual Science, 

University of Rochester, Rochester, NY; 3 The 

Institute of Optics, University of Rochester, 

Rochester, NY *CR 

4879 — D0318 A Novel Rodent Model of 

Retinal Edema. Xin Xia 1, 2 , M. Zheng 1 , R. Wen 3 , W. 

Chen 1 , Q. Gu 1, 2 . 1 Shanghai First People’s Hospital, 

Shanghai Jiao Tong University, Shanghai, China; 

2 

Shanghai Key Laboratory for Ocular Fundus 

Diseases, Shanghai, China; 3 Bascom Palmer Eye 

Institute, University of Miami, Miami, FL *CR 

4880 — D0319 Single- and multi-photon 

fluorescence retinal imaging in the intact rodent 

eye: a comparison. Adi Schejter, N. Farah, L. Tsur, 

S. Shoham. Biomedical Engineering, Technion, 

Haifa, Israel 

4881 — D0320 Retinal intrinsic optical signals 

in rabbits. Azadeh Naderian 1, 2 , L. Bussieres 1 , S. 

Thomas 1 , F. Lesage 2 , C. Casanova 1 . 1 University 

of Montreal, montreal, QC, Canada; 2 Ecole 

Polytechnique, montreal, QC, Canada *CR 

4882 — D0321 Contrast-enhanced MRI 

of Brain Abnormalities and Cerebrospinal 

Fluid (CSF) Buildup in CEP290 Knockout 

(ko) Mice: Effect of Ciliogenesis on Volumetry 

of CSF, Cerebrum and Cerebellum. Mrinal 

K. Dewanjee, R. A. Rachel, E. Yamamoto, J. P. 

Munasinghe, L. Dong, A. Swaroop. Neurobiology- 

Neurodegeneration & Repair, National Eye 

Institute, Bethesda, MD 

4883 — D0322 Retinal thickness changes 

in mice with streptozotocin-induced diabetes 

mellitus quantified using an enhanced Iowa 

Reference Algorithm. Woo Jin Jeong 1, 2 , M. D. 

Abramoff 1, 3 , B. J. Antony 4 , C. Jiao 1 , M. K. Garvin 3, 5 , 

E. H. Sohn 1 . 1 Institute for Vision Research, 


of Iowa, Iowa city, IA; 2 Ophthalmology, Dong-A 

University College of Medicine and Medical 

Science Research Center, busan, Republic of Korea; 

3 

Iowa Institute for Biomedical Imaging, University 

of Iowa, Iowa city, IA; 4 Department of Electrical 

and Computer Engineering, Iowa city, IA; 5 VA 

Medical Center, Iowa city, IA *CR 

4884 — D0323 Application of phase variance 

optical coherence tomography for in-vivo 

imaging of retinal micro-vasculature in mice. 

Robert J. Zawadzki 1, 2 , Y. Jian 3 , M. V. Sarunic 3 , J. S. 

Werner 2, 4 , E. N. Pugh 1, 5 . 1 Cell Biology and Human 

Anatomy, Univerisy of California Davis, Davis, 

CA; 2 Ophthalmology & Vision Science, University 

of California Davis, Sacramento, CA; 3 Engineering 

Science, Simon Fraser University, Burnaby, BC, 

Canada; 4 Neurobiology, Physiology, and Behavior, 

Univeristy of California Davis, Davis, CA; 

5 

Physiology and Membrane Biology, Univeristy of 

California Davis, Davis, CA 

4885 — D0324 Correcting Lateral 

Magnification in OCT Imaging of the Rat Eye. 

Diana C. Lozano, M. D. Twa. College of Optometry, 

University of Houston, Houston, TX 

4886 — D0325 Inner Retinal Oxygen 

Metabolism and Delivery in Streptozotocin 

Diabetic Rats. Justin Wanek, P. Teng, N. P. Blair, 

M. Shahidi. Ophthalmology and Visual Sciences, 

University of Illinois at Chicago, Chicago, IL *CR 

4887 — D0326 In vivo imaging of a new 

indocyanine green micelle formulation in an 

animal model. Steffen Schmitz-Valckenberg 1 , J. 

Meyer 1 , A. R. Cunea 1 , P. Welker 2 , K. Licha 2 , D. 

Sonntag-Bensch 1 , F. G. Holz 1 . 1 Ophthalmology, 

University of Bonn, Bonn, Germany; 2 mivenion 

GmbH, Berlin, Germany *CR 

4888 — D0327 Retinal OCT Reflectivity 

Profiles In Three Laboratory Animal Species. 

Marina Garcia Garrido 1 , C. Seide 1 , V. Sothilingam 1 , 

S. Julien 2 , U. Schraermeyer 2 , N. Tanimoto 1 , M. W. 

Seeliger 1 . 1 Division of Ocular Neurodegeneration, 

Ctr Ophthal Inst Ophthalmic Resrch, Tuebingen, 

Germany; 2 Section of Experimental Vitreoretinal 

Surgery, Ctr Ophthal Inst Ophthalmic Resrch, 


4889 — D0328 Functional imaging of retina 

in response to defocused grating light stimuli in 

cats. Yoko Hirohara 1, 2 , T. Mihashi 3, 2 , H. Kanda 2 , 

T. Miyoshi 4 , T. Morimoto 5 , J. S. Wolffsohn 6 , T. 

Fujikado 2 . 1 Optical Engineering Laboratory, Topcon 

Corporation, Itabashi-ku, Japan; 2 Department 

of Applied Visual Science, Osaka University 

Graduate School of Medicine, Suita, Japan; 

3 

Innovative Research Initiatives, Tokyo Institute 

of Technology, Yokohama, Japan; 4 Department of 

Integrative Physiology, Osaka University Graduate 

School of Medicine, Suita, Japan; 5 Department of 

Ophthalmology, Osaka University Graduate School 

of Medicine, Suita, Japan; 6 and Health Science, 

Aston University, Birmingham, United Kingdom 

*CR 

4890 — D0329 Peripapillary Rat Sclera 

Investigated Using Polarization Sensitive 

Optical Coherence Tomography Imaging and 

Histological Analysis. Bernhard Baumann 1 , 

S. Rauscher 2 , M. Glösmann 3 , M. Bonesi 1 , E. 

Gotzinger 1 , M. Pircher 1 , H. Sattmann 1 , S. Zotter 1 , 

T. Torzicky 1 , C. K. Hitzenberger 1 . 1 Ctr for Med 

Physics & Biomed Engineering, Medical University 

of Vienna, Vienna, Austria; 2 Core Facility Imaging, 

Medical University of Vienna, Vienna, Austria; 

3 

Core Facility for Research and Technology, 

University of Veterinary Medicine Vienna, Vienna, 

Austria *CR 

4891 — D0330 Pharmacokinetics of I-124 

aflibercept after intravitreal injection using 

PET/CT imaging after lensectomy in a rabbit 

model. John B. Christoforidis 1 , M. M. Williams 2 , 

F. M. Epitropoulos 3 , M. V. Knopp 2 . 1 Department 

of Ophthalmology and Vision Science, University 

of Arizona College of Medicine, Tucson, AZ; 

2 

Radiology, The Ohio State University College 

of Medicine, Columbus, OH; 3 Ophthalmology, 

The Ohio State University College of Medicine, 

Columbus, OH 

4892 — D0331 Segmentation of Multiple 

Intra-retinal Surfaces in Volumetric SD-OCT 

Images of Mouse Eyes Using an Improved 

Iowa Reference Algorithm. Bhavna J. Antony 1, 3 , 

M. D. Abramoff 2, 3 , W. Jeong 4 , E. H. Sohn 4 , M. K. 

Garvin 3, 1 . 1 Department of Electrical and Computer 

Engineering, The University of Iowa, Iowa City, 

IA; 2 Department of Ophthalmology and Visual 

Sciences, The University of Iowa, Iowa City, IA; 

3 

Center for the Prevention and Treatment of Visual 

Loss, VA Health Care System, Iowa City, IA; 

4 

Institute of Vision Research, Ophthalmology and 

Visual Sciences, The University of Iowa, Iowa City, 

IA *CR 


312


4893 — D0332 Spectral-Domain Optical 

Coherence Tomography of the Optic Nerve 

Head in a Canine Model of Primary Open-Angle 

Glaucoma. Annie Oh 1, 2 , C. Harman 1 , K. L. Koehl 1 , 

J. Huang 3 , L. B. Teixeira 4 , L. M. Occelli 1 , E. Storey 5 , 

G. Ying 3 , A. M. Komaromy 1, 6 . 1 College of Veterinary 

Medicine, Michigan State University, East Lansing, 

MI; 2 College of Veterinary Medicine, Western 

University of Health Sciences, Pomona, CA; 

3 

Scheie Eye Institute, University of Pennsylvania, 

Philadelphia, PA; 4 School of Veterinary Medicine, 

University of Wisconsin-Madison, Madison, WI; 

5 

School of Veterinary Medicine, Louisiana State 

University, Baton Rouge, LA; 6 School of Veterinary 

Medicine, University of Pennsylvania, Philadelphia, 

PA 

4894 — D0333 Imaging Functional Hyperemia 

in Response to Flicker Stimulus in the Rat 

Retina Using Ultrahigh-Speed Spectral / Fourier 

Domain OCT. WooJhon Choi 1 , A. Clermont 2 , E. 

P. Feener 2 , D. Boas 3 , J. G. Fujimoto 1 . 1 Electrical 

Engineering, Massachusetts Institute of Technology, 

Cambridge, MA; 2 Beetham Eye Institute, Joslin 

Diabetes Center, Boston, MA; 3 Athinoula 

A. Martinos Center for Biomedical Imaging, 

Massachusetts General Hospital, Charlestown, MA 

*CR 

4895 — D0334 Dynamics of Retinal Pathology 

in BALB/cJ Mice Housed in Cyclic Light 

Conditions: An Imaging Study to Elucidate 

Changes Induced by Long Term Exposure. Brent 

A. Bell 1 , C. A. Kaul 1 , I. S. Samuels 1, 2 , V. L. Bonilha 1 , 

M. E. Rayborn 1 , J. G. Hollyfield 1, 3 . 1 Department of 

Ophthalmic Research, Cole Eye Institute, Cleveland 

Clinic, Cleveland, OH; 2 Research Service, Louis 

Stokes Cleveland VA Medical Center, Cleveland, 

OH; 3 Department of Ophthalmology, Cleveland 

Clinic Lerner College of Medicine at Case Western 

Reserve University, Cleveland, OH 

4896 — D0335 Microstructural and 

physiological alterations in hypoxic-ischemicinjured 

visual system. Swarupa Kancherla 1 , K. C. 

Chan 1, 2 . 1 UPMC Eye Center, Eye and Ear Institute, 

Ophthalmology and Visual Science Research 

Center, Department of Ophthalmology, University 

of Pittsburgh, Pittsburgh, PA; 2 Department 

of Bioengineering, University of Pittsburgh, 

Pittsburgh, PA 

4897 — D0336 Development of a Rat Model for 

Retrobulbar Angiography of X-Ray Computed 

Tomography with an Iodine-Containing Polymer. 

Kenji Matsushita, R. Kawashima, S. Usui, K. 

Nishida. Ophthalmology, Osaka University Medical 

School, Suita, Japan *CR 



Retina 

446 Imaging I, RE 

Moderators: Michael D. Abramoff, Cynthia A. 

Toth and Camiel J. Boon 

4898 — D0337 Qualitative and quantitative 

changes of cystoid macular edema treated with 

Ozurdex therapy. Raeba Mathew 1 , E. Pearce 1, 2 , 

S. Sivaprasad 2, 1 . 1 Ophthalmology, King’s College 

Hospital, London, London, United Kingdom; 

2 

Ophthalmology, Moorfields Eye Hospital, London, 

United Kingdom *CR, f 

4899 — D0338 Retinal Blood Flow Velocities 

in Patients with Retinal Vein Occlusion. Gennady 

Landa, N. K. Scripsema, R. B. Rosen. Department of 

Ophthalmology, New York Eye and Ear Infirmary, 


4900 — D0339 Prediction of visual prognosis 

with spectral domain optical coherence 

tomography in outer retinal atrophy secondary 

to closed-globe trauma. Haoyu Chen, Y. Lu, H. 

Huang, J. Zheng, P. Hou, W. Chen. Joint Shantou 

International Eye Center, Shantou, China 

4901 — D0340 Automated Detection and 

Location Analysis of Diabetic Cysts in Retinal 

OCT Images: An Iterative Filtering Approach. 

Sohini RoyChowdhury 1 , D. D. Koozekanani 2 , S. 

Radwan 2, 3 , K. K. Parhi 1 . 1 Electrical Engineering, 

University of Minnesota, Minneapolis, MN; 

2 


Minnesota, Mineapolis, MN; 3 Ophthalmology, 

Cairo University, Cairo, Egypt *CR 

4902 — D0341 Evaluation Of Functional 

And Morphological Parameters In Patients 

With RVO Treated With Intravitreal Steroid 

Implant. Simone Donati, E. Melardi, M. Al 

Oum, C. Gandolfi, M. Bianchi, R. Vinciguerra, C. 

Azzolini. Department of Morphological and Surgical 

Sciences, University of Insubria-Circolo Hospital, 

Varese, Italy 

4903 — D0342 Macular Thickness Evaluation 

in Young Patients With Type 1 Diabetes Mellitus 

and Healthy Controls. Muna Al Oum 1 , S. Donati 1 , 

C. Gandolfi 1 , L. Premoli 1 , M. Chiaravalli 1 , M. 

Marazza 2 , A. Salvatoni 2 , C. Azzolini 1 . 1 Department 

of Surgical and Morphological Science, 

University of Insubria-Circolo Hospital, Varese, 

Italy; 2 Department of Clinical and Experimental 

Medicine, University of Insubria-Del Ponte 

Hospital, Varese, Italy 

4904 — D0343 Yearly Loss of Retinal 

Thickness and Macular Volume Estimated from 

SPECTRALIS OCT Measurements in Patients 

with Stargardt Macular Dystrophy. Rupert W. 

Strauss 1, 2 , E. Fletcher 1, 3 , Y. Wolfson 1 , H. P. Scholl 1 . 

1 

Wilmer Eye Institute, Johns Hopkins University, 

Baltimore, MD; 2 Dept. of Ophthalmology, 

Medical University Graz, Graz, Austria; 3 Dept. of 

Ophthalmology, Cheltenham General Hospital, 

Gloucestershire Hospitals NHS Foundation Trust, 

Cheltenham, United Kingdom 

4905 — D0344 Choroidal Thickness in Healthy 

Pregnant Women Using EDI-OCT. Eric K. Chin, 

K. V. Lam, K. Chandra, E. F. Redenbo, S. S. Park. 

Ophthalmology, UC Davis Eye Center, Sacramento, 

CA 

4906 — D0345 Prevalence Of Epiretinal 

Membrane In Eyes That Underwent Scleral 

Buckle Surgery For Repair Of Primary 

Rhegmatogenous Retinal Detachment When 

Imaged By SD-OCT. Rosa E. Martinez-Munoz, J. 

J. Fromow-Guerra, V. Morales-Canton, V. Franco- 

Cardenas. Retina and Vitreous, Asociacion Para 

Evitar la Ceguera en Mexico, Mexico, Mexico *CR 

4907 — D0346 Clinical Feasibility and 

Utility of Ultra Wide-Field Indocyanine 

Green Angiography. Thomas L. Berenberg 1 , S. 

D. Bhaleeya 1 , M. M. Wessel 1 , M. T. Witmer 1 , S. 

Patel 1 , S. R. Sadda 2 , S. Kiss 1 . 1 Ophthalmology, 

Weill Cornell Medical College, New York, NY; 

2 

Ophthalmology, USC Doheny Eye Institute, Los 


4908 — D0347 Correlation of Posterior 

Inflammatory Leakage and Cystoid Macular 

Edema with Retinal Pigment Epithelium 

Atrophy in Retinitis Pigmentosa Evaluated 

with Optos Wide-field Fluorescein Angiography 

and Spectral Domain OCT. Carlos A. Medina- 

Mendez, M. B. Kaufman, A. W. Eller, T. R. Friberg. 

Ophthalmology, University of Pittsburgh Medical 

Center, Pittsburgh, PA *CR 

4909 — D0348 Correlation between 

Visual Acuity and Spectral Domain Optical 

Coherence Tomography Findings in Birdshot 

Chorioretinopathy Patients. Vincent Y. Ho 1 , 

J. Shantha 1 , F. Forooghian 2 , C. Bergstrom 1 , G. 

B. Hubbard 1 , T. W. Olsen 1 , P. Patel 1 , S. Yeh 1 . 

1 

Ophthalmology, Emory Eye Center, Atlanta, GA; 

2 

Ophthalmology, St. Paul’s Hospital, Vancouver, 

BC, Canada *CR 

4910 — D0349 Comparison of Optical 

Coherence Tomography Scan Patterns and 

Clinical Review Strategies in the Management of 

Neovascular Age-related Macular Degeneration. 

Robert J. Courtney, J. McClintic, J. P. Ehlers. 

Ophthalmology, Cole Eye Institute, Cleveland 

Clinic Foundation, Cleveland, OH *CR 

4911 — D0350 Perivascular fundus 

autofluorescence abnormalities in autoimmune 

retinopathy. Damien C. Rodger, G. M. Richter, H. 

Nazari Khanamiri, N. A. Rao. Doheny Eye Institute, 

Los Angeles, CA 

4912 — D0351 The clinical and spectraldomain 

optical coherence tomography findings 

in focal choroidal excavation. Christopher S. 

Lee 1 , S. Woo 2 , D. Hwang 2 , S. lee 1 . 1 Ophthalmology, 

Yonsei Univ College of Medicine, Seoul, Republic 

of Korea; 2 Ophthalmology, Seoul National Univ 

College of Medicine, Seoul, Republic of Korea 

4913 — D0352 Wide field imaging in 

Coat‘s disease. Carl F. Arndt, S. Masse, K. 

Vardi, A. Ducasse, O. Zambrowski. Service 

d’Ophthalmologie, Reims University Hospital, 

Reims, France *CR 


11:00 am – 12:45 pm 


313



11:00 am – 12:45 pm 

4914 — D0353 Reproducibility and 

Agreeability of Automated Retinal 

Pigment Epithelial Detachment Volumetric 

Measurements via Spectral Domain Optical 

Coherence Tomography. Joseph Ho 1 , M. Adhi 1 , E. 

Cole 1 , J. J. Liu 2 , J. G. Fujimoto 2 , J. S. Duker 1 , N. 

K. Waheed 1 . 1 Department of Ophthalmology, Tufts- 

New England Eye Center, Boston, MA; 2 Research 

Laboratory of Electronics, Massachusetts Institute 

of Technology, Cambridge, MA *CR 

4915 — D0354 Use of SD-OCT/SLO as an 

alternative to ultrasonography to monitor 

patients with recurrent retinal detachments 

and silicone oil tamponade. Jessica N. Taibl 1, 2 , 

S. I. Sayegh 1 . 1 The EYE Center, Champaign, IL; 

2 

University of Illinois, Urbana-Champaign, IL 

4916 — D0355 Long-term changes of 

fudus autofluorescence in central serous 

chorioretinopathy. Tetsuju Sekiryu, H. Oyamada, 

K. Imaizumi, T. Mori, I. Maruko. Ophthalmology, 

Fukushima Medical University, Fukushima, Japan 



Retina 

447 DME: OCT and Function 

Moderators: Masahiko Shimura and 

Francesco Bandello 

4917 — D0356 Correlations between Retinal 

Morphological Changes and Concentrations of 

Cytokines in Eyes with Diabetic Macular Edema. 

Shozo Sonoda, T. Yamashita, M. Shirasawa, H. 

Otsuka, Y. Sonoda, T. Sakamoto. Department of 

Ophthalmology, Kagoshima University, Kagoshima, 

Japan 

4918 — D0357 Correlation between Diabetic 

Macular Edema (DME) and extraocular 

complications observed during diabetes. 

Olivier Lichtwitz 1 , N. Leveziel 1 , M. Boissonnot 1 , 

A. Miot 2 , X. Piguel 2 , F. Torremocha 2 , P. Saulnier 3 , 

R. Maréchaud 2 , S. Hadjadj 2 . 1 Ophthalmology, 

Hospital University of Poitiers, Poitiers, France; 

2 

Endocrinollogy, Hospital University of Poitiers, 

Poitiers, France; 3 Center of Clinical Investigation, 

INSERM CIC 802, Poitiers, France *CR 

4919 — D0358 Evaluation of choroidal 

thickness by enhanced depth imaging OCT in 

the LUCIDATE study: a randomised clinical 

trial to compare outcomes of ranibizumab 

with laser in diabetic macular oedema. Rishma 

Gohil 1, 2 , O. Comyn 1 , P. A. Keane 1 , P. J. Patel 1 , J. W. 

Bainbridge 1 , S. Sivaprasad 1, 2 , P. G. Hykin 1 . 1 NIHR 

Biomedical Research Centre at Moorfields Eye 

Hospital NHS Foundation Trust and UCL Institute 


2 

King’s College London, London, United Kingdom 

*CR, f 

4920 — D0359 Chromatic sensitivity in 

diabetic patients treated with Ozurdex. Ahmed 

F. Abdel-hay 1, 2 , S. Sivaprasad 1 , A. Subramanian 2 , 

E. Konstantakopoulou 2 , D. F. Edgar 2 , J. L. Barbur 2 . 

1 

Ophthalmology, King’s College Hospital, London, 

United Kingdom; 2 1Applied Vision Research 

Centre, City University London, London, United 

Kingdom *CR, f 

4921 — D0360 Longitudinal Comparison of 

Visual Acuity as Measured by ETDRS Chart and 

by Potential Acuity Meter in Eyes with Macular 

Edema and Its Relationship with Macular 

Sensitivity and Thickness. Elham Hatef Naimi 1, 2 , 

M. Hanout 1 , O. O. Agbedia 1 , A. Moradi 1 , D. V. 

Do 1 , D. L. Guyton 1 , Q. Nguyen 1 . 1 Ophthalmology, 

Wilmer Eye Inst, Johns Hopkins Univ, Baltimore, 

MD; 2 General Preventive Medicine, Johns Hopkins 

Bloomberg School of Public Health, Baltimore, 

MD *CR 

4922 — D0361 Retinal Perifoveal Inner 

Layer Disorganization as a Predictor of Visual 

Acuity Outcomes in Eyes with Center-involved 

Diabetic Macular Edema. Michael M. Lin 1, 7 , R. 

Sarangi 1, 2 , J. Lammer 1, 3 , A. Y. Ganjei 1 , S. Radwan 4, 

5 

, A. Z. Soliman 4, 5 , P. S. Silva 1, 6 , L. P. Aiello 1, 

6 

, J. K. Sun 1, 6 . 1 Beetham Eye Institute, Joslin 

Diabetes Center, Boston, MA; 2 Boston University 

School of Medicine, Boston, MA; 3 Department 

of Ophthalmology and Optometry, Medical 

University Vienna, Vienna, Austria; 4 Department 

of Ophthalmology, University of Minnesota, 

Minneapolis, MN; 5 Department of Ophthalmology, 

Cairo University, Cairo, Egypt; 6 Department of 

Ophthalmology, Harvard Medical School, Boston, 

MA; 7 Harvard Medical School, Boston, MA *CR 

4923 — D0362 The effect of hard exudates 

and epiretinal fibrosis on the retinal thickness 

as calculated by optical coherence tomography 

(OCT) in diabetic macular edema. Delila Hodzic 1 , 

B. A. Sander 1 , H. Lund-Andersen 1, 2 . 1 Department 

of ophthalmology, Glostrup Hospital, Glostrup, 

Denmark; 2 Faculty of Health Sciences, University 

of Copenhagen, Copenhagen, Denmark 

4924 — D0363 Correlation of structural and 

visual function tests in patients with diabetic 

macular edema. Elizabeth Pearce, R. Mathew, A. 

F. Abdel-hay, S. Sivaprasad. Ophthalmology, King’s 

College Hospital, London, United Kingdom *CR, f 

4925 — D0364 Retinal Layer Thicknesses 

in SDOCT Images for Diabetics with Hard 

Exudates. Joel A. Papay 1 , A. E. Elsner 1 , C. A. 

Clark 1 , V. Malinovsky 1 , S. G. Brahm 1 , S. B. Young 1 , 

A. V. Walker 1 , T. V. Litvin 2 , G. Y. Ozawa 2 , J. A. 

Cuadros 2 . 1 School of Optometry, Indiana University, 

Bloomington, IN; 2 School of Optometry, UC 


4926 — D0365 Retinal thickness reduction 

and layers involvement in different diseases 

visualized by SD-OCT. Michele M. Iester 1 , L. 

Borgia 2 . 1 DiNOGMI, University of Genoa, Genova, 

Italy; 2 Is.Pre Oftalmica, Genoa, Italy 

4927 — D0366 Visual acuity evaluation in 

patients treated with ranibizumab for diabetic 

macular edema. Marc Stahel 1 , P. P. Ciechanowski 1 , 

F. Moser 1 , S. Lortz 1 , H. M. Fassnacht 1 , N. T. Graf 2 , 

M. D. Becker 1 , S. Michels 1 . 1 Ophthalmology, 

Triemli Hospital Zurich, Zurich, Switzerland; 2 Graf 

Biostatistics, Winterthur, Switzerland *CR 

4928 — D0367 Differences in the topographic 

profile of retinal thickening in cases of diabetic 

macular edema with and without serous 

macular detachment. Hannah Shereef 1, 4 , O. 

Comyn 2 , S. Sivaprasad 2 , P. G. Hykin 2 , G. C. 

Cheung 3 , N. Narendran 4 , Y. C. Yang 4 . 1 University 

of Birmingham, Birmingham, United Kingdom; 

2 

National Institute for Health Research Biomedical 

Research Centre at Moorfields Eye Hospital 

NHS Foundation Trust and UCL Institute of 

Ophthalmology, London, United Kingdom; 

3 


Singapore; 4 Royal Wolverhampton Hospitals NHS 

Trust, Wolverhampton, United Kingdom *CR 

4929 — D0368 Use of a Retinal Acuity Meter 

(RAM) and Brightness Acuity Meter (BAM) to 

Identify Early Diabetic Macular Edema. Albert 

Li, D. J. Sackel, A. Chen, L. Park. Ophthalmology, 

NYU School of Medicine, New York, NY 

4930 — D0369 Optimal treatment strategy 

for Stage 5 Type 2A Idiopathic Macular 

Telangiectasia with anti-vascular endothelial 

growth factor (VEGF) agents - When to stop? 

Sharad S. Malavade, S. Cohen. Ophthalmology, 

University of South Florida, Tampa, FL 

4931 — D0370 Safety, sterility and stability of 

direct- from- vial multiple dosing intravitreal 

injection of bevacizumab. Taraprasad Das 1 , S. 

Volety 2 , S. M. Ahsan 2 , A. K. Thakur 2 , S. Sharma 1 , 

S. Basu 1 , T. R. Padhi 1 , M. Rao 2 . 1 Retina Vitreous 

Services, LV Prasad Eye Institute, Bhubaneswar, 

India; 2 Center for Cellular and Molecular Biology, 

Hyderabad, India 

4932 — D0371 Increased Healthcare Cost 

Related To Adding Dexamethasone Implant 

(Ozurdex ® ) To Bevacizumab (Avastin ® ) 

Monotherapy In Patients With Cystoid Macular 

Edema (CME) Due To Retinal Vein Occlusion 

(RVO) May Be Balanced By Less Frequent 

Follow-Up. Omar Saleh, J. Heroman, S. Schaal. 

University of Louisville, Louisville, KY 

4933 — D0372 Reperfusion of ischemia with 

central retinal vein occlusion by activated 

protein C. Motohiro Kamei, N. Matsumura, M. 

Suzuki, S. Sakimoto, H. Sakaguchi, K. Nishida. 

Ophthalmology, Osaka Univ Grad School of 

Medicine, Suita, Japan *CR, f 

4934 — D0373 The Efficacy of Single 

Intravitreal Ranibizumab Injection in Acute 

Nonarteritic Ischemic Optic Neuropathy. Ali 

Osman Saatci, O. Taskin, O. Barut Selver, A. Yaman, 

M. Soylev Bajin. Ophthalmology Department, 

Dokuz Eylul University, Izmir, Turkey 


314


4935 — D0374 Influence of Axial Length 

and Degree of Injection Reflux on Sustained 

Intraocular Pressure Elevation Due to 

Intravitreal Anti-Vascular Endothelial 

Growth Factor Therapy. Luis Mendonca 1, 2 , Q. 

V. Hoang 2, 3 , J. J. Jung 4 , S. Mrejen 2 , K. Freund 2, 

3 

. 1 Ophthalmology, Hospital de Braga, Braga, 

Portugal; 2 Vitreous, Retina, Macula Consultants 

of New York, New York, NY; 3 Ophthalmology, 

Columbia University Medical Center, New York, 

NY; 4 Ophthalmology, New York University, New 

York, NY *CR 

4936 — D0375 Ranibizumab versus 

Bevacizumab in the treatment of subfoveal 

choroidal neovascular membrane secondary 

to pathologic myopia. Ramón Domínguez 

Fernández 1 , A. Govetto 1 , M. Alves Perez 2 , R. 

Lorente 1 . 1 Ophthalmology, CHU Ourense, Ourense, 

Spain; 2 Biostatistics, CHU Ourense, Ourense, Spain 

4937 — D0376 Changes in retinal layer 

morphology following intra-vitreal Ozurdex 

therapy for macular oedema secondary to 

Retinal Vein Occlusion. Rashmi Akshikar, S. 

Sivaprasad. Ophthalmology, Kings College 

Hospital London, London, United Kingdom *CR 


11:00 am – 12:45 pm 


315

Wednesday – Workshop/SIGs 

TCC 304 

Wednesday, May 08, 2013 1:00 PM-2:30 PM 


448 Multidisciplinary Ophthalmic 

Imaging Group: Functional 

Optical Imaging 

606/607 


449 Managing Your Research, Teaching 

and Service: “Dollarly/Scholarly” 

611-614 


450 Getting Published: The Good, the 

Bad, and the Ugly 

Wednesday Workshops/ 

SIGs 

1:00 pm – 2:30 pm 

Optical techniques are known to provide high 

resolution images of tissue structures. Technological 

advances in optical coherence tomography, 

scanning laser ophthalmoscopy, photoacoustic 

ophthalmoscopy now provide means for imaging 

function as well. The possible functional 

measurements include ocular blood flow, oxygen 

tension, and their responses to visual stimulation. 

These techniques are useful for in vivo investigation 

in both animals and humans. Clinical applications 

may be possible in the future. 

Moderators: Joel S. Schuman, David Huang 

and Gadi Wollstein 


— 1:05 Laser Speckle Flowgraphy in 

Glaucoma. Toru Nakazawa. Ophthalmology, 

Tohoku Univ Graduate Sch of Med, Sendai, Japan 

*CR 

— 1:20 Dual-beam Bidirectional OCT. Leopold 

Schmetterer. Clinical Pharmacology, Medical 

University of Vienna, Vienna, Austria 

— 1:35 Erythrocyte Velocity Measurement 

with Adaptive Optics Scanning Laser 

Ophthalmoscopy. Stephen A. Burns. School of 

Optometry, Indiana University, Bloomington, IN 

— 1:50 Retinal Oxymetry by Photoacoustic 

Ophthalmoscopy. Hao F. Zhang. Biomedical 

Engineering, Northwestern University, Evanston, 

IL *CR 

— 2:05 Retinal Oxygen Tension Imaging. 

Mahnaz Shahidi. Ophthalmology & Visual 

Sciences, University of Illinois at Chicago, Chicago, 

IL *CR 

— 2:20 Discussion/Business Meeting 

Managing time commitments is an extremely 

important skill needed to accomplish your 

professional goals. As a faculty member in a 

research university, the three major areas of work 

are 1) research, 2) teaching, and 3) committee/ 

community service. For those in industry research 

positions, personnel management may replace 

teaching as a component of your job. The level of 

success in these areas plays a major role in your 

personnel evaluations and your promotions. This 

is an area of professional life that is rarely taught 

in formal presentations. As a young professional, 

from a diverse background (a woman or, a 

minority, or both), you will find yourself pulled 

in various directions as many people want you 

to serve on their different committees, in order 

to meet institutional diversity requirements. This 

workshop will concentrate on managing your time 

and effort, both quantitatively and qualitatively, to 

achieve success in all three areas. Implicit in this 

management effort is success in providing time for 

yourself and family. The invited speaker(s) will 

address their own experiences, challenges, failures 

and successes in this critical area of professional 

life. From their life experience, you may gain 

valuable knowledge and skills to navigate this 

important aspect of your life. 

Moderators: Jerome Wujek and Joseph Carroll 


— 1:05 Presentation. Janey L. Wiggs. 

Ophthalmology-Harvard Med Sch, Mass Eye & Ear 

Infirmary, Boston, MA 

— 1:17 Presentation. Emily Y. Chew. 

Epidemiology & Clinical Applications, National 

Eye Inst/NIH, Bethesda, MD 

— 1:29 Presentation. Terri L. Young. 

Ophthalmology, Duke University Eye Center, 

Durham, NC *CR 

— 1:41 Presentation. Nisha Acharya. Ophthal- 

Proctor Foundation, Univ of California - SF, San 

Francisco, CA 

— 1:53 Presentation. Cynthia L. Grosskreutz. 

Ophthalmology, Novartis Inst for Biomed Resrch, 


— 2:05 Discussion 

This workshop will focus on practical and 

ethical issues relevant to publishing and the peer 

review process, addressing the responsibilities 

of both authors and reviewers. Topics will 

include: plagiarism, its definition, detection, 

and consequences; the elements of a “good” 

(constructive) review, and things to avoid when 

writing reviews; reviewer conflicts of interest, and 

maintaining confidentiality. 

Moderators: Steven J. Fliesler and 

Ron A. Adelman 


— 1:05 Authorship Ethics: Plagiarism - 

Walking on the Dark Side. Steven J. Fliesler. 

Ophthalmology, SUNY-Buffalo / VA Med Ctr- 

Buffalo, Buffalo, NY 

— 1:30 Good Reviews, Bad Reviews: How to 

Do One and Not the Other. Jeffrey H. Boatright. 

Ophthalmology, Emory University School of Med, 

Atlanta, GA 

— 1:55 Reviewer Ethics: Doing the Right 

Thing. David C. Beebe. Ophthalmol & Visual Sci, 

Washington Univ, St Louis, MO *CR 



316

Wednesday – Workshops/SIGs 

615-617 


451 Indo-US Collaborative Vision 

Research Program 

TCC 301/302 


452 Pizza with the Experts #2 

6A 


Retinal Cell Biology / Retina 

454 What Role Do Mueller Glial Cells 

Play in Retinal Pathology? - SIG 

The Indo-U.S. Collaborative Vision Research 

Program has supported more than a dozen 

collaborative and productive relationships since its 

formalization in 2005. The representatives of the 

governments of India and the U.S. have worked 

together to create a number of opportunities for 

the vision researchers to jointly submit and receive 

funding to pursue projects on genetic ocular traits, 

cataract, glaucoma, diabetic retinopathy, retinal 

degeneration and neuroplasticity. The program is 

supported by the R01 research grant at NIH and 

an award mechanism supported by the Department 

of Biotechnology, Government of India. Leading 

vision researchers from the US and India will 

discuss the current programs, future opportunities, 

award mechanisms, various challenges and ways 

to achieve successful results in a collaborative 

program across the globe. The participants will have 

the opportunity to learn about the scientific projects 

sponsored through the bilateral research program. 

Moderators: Gyan Prakash and T.S. Rao 

— 1:00 Intervational Vision Research. Paul A. 

Sieving. National Eye Institute, Bethesda, MD 

— 1:12 Overview of Application Process 

for Indo-US Vision Research Program. Gyan 

Prakash. National Eye Institute, NIH, Bethesda, 

MD 

— 1:24 Vision Research Projects - 

Collaborative Case Studies. C M. Rao. Center for 

Cell & Molec Biology, Hyderabad, India 

— 1:36 Indo-US Programs: Challenges and 

Benefits of the Bilateral Scientific Research 

Opportunities. Nandita Chopra. Dept. of Health & 

Human Services, US Embassy, Bethesda, MD 

— 1:48 India US Genetic Study of 

Ocular Quantitative Traits. Janey L. Wiggs. 

Ophthalmology-Harvard Med Sch, Mass Eye & Ear 


— 2:00 Diabetic Retinopathy - The Looming 

Global Health Crisis. P. Namperumalsamy. 

Research, Aravind Medical Research Foundation, 

Madurai, India 


Advance registration required. Trainees, 

students and junior faculty, don’t miss this 

unique opportunity to network and gain valuable 

information from those who have been in your 

shoes! This very popular program offers informal 

discussions over a pizza lunch on a wide range of 

topics to provide personal guidance, insight and 

skills to help you advance your career! Topics will 

focus on professional development, career guidance, 

and best practices of interest to basic and clinical 

trainees and clinician-scientists. A number of the 

roundtable topics will be specifically tailored to the 

needs of clinician-scientists. 

TCC 303 


453 NIH-CSR Peer Review Workshop 

Sponsored by the NIH Center for Scientific Review 

(CSR), this workshop is designed to inform grant 

applicants and also reviewers about the NIH peer 

review process and the changes that have occurred, 

including the recent reorganization of study sections 

that review visual system grant applications. 

Scientific Review Officers (SROs) from CSR will 

be on hand for the presentation and will be available 

to answer questions. 

Moderator: Michael H. Chaitin 

— 1:00 Overview: Peer Review 

— 1:20 Biology of the Visual System (BVS) 

Study Section. Michael H. Chaitin. Center for 

Scientific Review, NIH, Bethesda, MD 

— 1:30 Diseases and Pathophysiology of the 

Visual System (DPVS) Study Section. Nataliya 

V. Gordiyenko. Center for Scientific Review, NIH, 

Bethesda, MD 

— 1:40 Small Business: Sensory Technologies 

[ETTN-12] Study Section. Paek-Gyu Lee. Center 

for Scientific Review, NIH, Bethesda, MD 

— 1:50 Bioengineering of Neuroscience, Vision, 

and Low Vision Technologies (BNVT) Study 

Section. Robert C. Elliott. Center for Scientific 

Review, NIH, Bethesda, MD 

— 2:00 Title - to be determined by author. 

Maqsood A. Wani. NIH, Bethesda, MD 

— 2:10 Panel Discussion 

Very little is known about the contribution of 

Mueller cells to the pathogenesis of retinal 

disease. Evidence will be presented suggesting 

that Mueller cell dysfunction may result in key 

vision-threatening events, such as photoreceptor 

degeneration and retinal edema. 

Moderators: Marcus Fruttiger and G Astrid Limb 

— 1:00 SIG Organizer. Mark C. Gillies. 

Ophthalmology, University of Sydney, Sydney, 


— SIG Organizer. Francine F. Behar-Cohen. 

Ophthalmology, Hotel Dieu de Paris, Universite 

Paris Descartes, Paris, France *CR 

— Consequences of Selective Muller cell 

Ablation in a Transgenic Model. Mark C. Gillies. 

Ophthalmology, University of Sydney, Sydney, 


— Glia in Retinal Vascular Disease. Erica L. 

Fletcher. Dept Anatomy/Neuroscience, University 

of Melbourne, Parkville, VIC, Australia *CR 

— Retinal Glia: Novel Mineralocorticoid 

Targets. Francine F. Behar-Cohen. Ophthalmology, 

Hotel Dieu de Paris, Universite Paris Descartes, 

Paris, France *CR 

6B 


Retina 

455 Diabetic Retinopathy: Where We 

Are and a Path to Progress - SIG 

The Lasker/IRRF Initiative explored diabetic 

retinopathy, a serious ocular complication of 

diabetes mellitus, and the possible connection 

between the rise in blood glucose levels to changes 

in neuronal/glial function and to vascular changes 

that eventually can destroy vision in the eye. 

Moderator: John E. Dowling 

— SIG Organizer. John E. Dowling. Molecular 

and Cellular Biology, Harvard University, 

Cambridge, MA 

— Vascular and Neuronal Repair. Robert N. 

Frank. Ophthalmology, Wayne State Univ/Kresge 

Eye Inst, Detroit, MI 

— Early Signs of Diabetic Retinopathy. Thomas 

W. Gardner. Ophthalmology, Kellogg Eye Ctr Univ 

of Michigan, Ann Arbor, MI *CR 

Wednesda Workshops/ 

SIGs 

1:00 pm – 2:30 pm 


317

Wednesday – Workshop/SIGs 

Wednesday Workshops/ 

SIGs 

1:00 pm – 2:30 pm 

— Role of Glucose, Lipids and Oxygen 

in Diabetic Retinopathy. Timothy S. Kern. 

Department of Medicine, Case Western Reserve 

Univ, Cleveland, OH *CR 

— Diagnostic Methods. Larry A. Donoso. 

Research, Philadelphia Retina Endowment Fund, 


— Present and Proposed Approaches to 

Therapeutics. Lloyd M. Aiello. Beetham Eye 

Institute, Joslin Diabetes Center, Boston, MA 

6C 



456 Epigenetic Mechanism and Ocular 

Diseases - SIG 

The SIG will update the research of epigenetic 

modifications in diabetic retinopathy, retinal 

development, corneal dystrophy, AMD and PVR 

and the roles of DNA-methylation, histoneacetylation 

and miRNA in the pathogenesis of 

these diseases and its treatment by epigenetic 

intervention. 

Moderator: Renu A. Kowluru 

— SIG Organizer. Renu A. Kowluru. 

Ophthalmology, Wayne State Univ/Kresge Eye Inst, 

Detroit, MI 

— Histone modifications in diabetic retinopathy. 

Renu A. Kowluru. Ophthalmology, Wayne State 

Univ/Kresge Eye Inst, Detroit, MI 

— DNA Methylation in RPE Transdifferentiation 

and its relevance to proliferative 

vitreoretinopathy. Shikun He. Ophthalmology- 

USC, Doheny Eye Institute, Los Angeles, CA 

— When Good RPE Break Bad: A meta-genomic 

analysis of chronic RPE stress and aging. 

Monte Radeke. Neuroscience Research Institute, 

University of California, Santa Barbara, CA 

— Epigenetic factors in the pathogenesis of 

corneal dystrophy. Xiaohua Li. Henan eye institue, 

Zhengzhou, China 

— Histone modification in regulation of retinal 

development. Dong F. Chen. Ophthalmology/ 

Harvard, Schepens Eye Res Inst, Harvard Med Sch, 


— DNA methylation in regulation of retinal 

development. Shannath L. Merbs. Ophthalmology, 

Wilmer Eye Institute, Johns Hopkins Univ, 

Baltimore, MD 

618-620 


Cornea / Biochemistry/Molecular Biology / 

Glaucoma / Retina 

457 Dietary Factors and Eye Health - 

SIG 

There is growing interest in dietary factors and 

supplements that may have protective effects 

against eye diseases. This SIG will focus on 

nutritional factors which are beneficial for the 

eye. Exciting new research data and potential 

mechanisms will be presented and discussed. 

Moderators: Kazuo Tsubota and Rajendra S. Apte 

— SIG Organizer. Kazuo Tsubota. Ophthalmology, 

Keio Univ School of Medicine, Shinjuku-ku, Japan 

*CR 

— Lutein, Zeaxanthin, and Omega-3 Fatty 

Acid Function in the Human Macula: The Basic 

Science Underlying AREDS2. Paul S. Bernstein. 

Ophthal and Visual Sciences, Univ of Utah/Moran 

Eye Center, Salt Lake City, UT *CR 

— The Protective Effects of Resveratrol are 

Mediated through Forkhead Box O Activity. 

Pratap Challa. Dept of Ophthalmology, Duke 

University Eye Center, Durham, NC 

— Omega-3 and Macular Pigment 

Accumulation: Results from the PIMAVOSA 

Study. Marie-Noelle Delyfer. Ophthalmology, 

Hopital Pellegrin, Bordeaux, France *CR 

— The Novel Potential of Lactoferrin for Ocular 

Surface Health. Motoko Kawashima. Department 

of Ophthalmology, Keio University School of 

Medicine, Shinjuku ku, Japan *CR 

TCC LL 4/5 


Retina 

458 New Paradigms and Emerging 

Techniques for Minimalist Macular 

Photocoagulation - SIG 

Laser treatments for macular edema have shifted 

toward minimal invasiveness in the era of anti- 

VEGF therapy. Various techniques including 

micropulsing, nanopulsing, and navigated 

microaneurysm treatment will be discussed. 

Moderators: William R. Freeman, Johann Roider, 

Bert M. Glaser and Giovanni Staurenghi 

— SIG Organizer. Richard B. Rosen. 

Ophthalmology, New York Eye & Ear Infirmary, 


— Navigated Laser Therapy. William R. Freeman. 

Ophthalmology, UCSD Jacobs Retina Center, La 

Jolla, CA *CR 

— Nanopulse Laser Therapy. Johann Roider. 

Klinik fur Ophthalmologie, University of Kiel, Kiel, 

Germany *CR 

— Micropulse Laser Therapy. Bert M. Glaser. 

Ocular Proteomics, National Retina Institute, 

Towson, MD *CR 

— Feeder Vessel Therapy. Giovanni Staurenghi. 

Dept of Biomedical and Clinical Science (Luigi 

Sacco), University of Milan, Milano, Italy *CR 


318

6B 


Glaucoma 

459 Neuroprotection 

6C 


Retina 

460 ROP: Management 


4951 — 4:15 Use of Computer-Assisted 

Quantitative Analysis of Retinal Vascular 

Dilation and Tortuosity to Predict Need for 

Laser Treatment in Retinopathy of Prematurity. 

Katherine Wu 1 , D. Wallace 2 , S. F. Freedman 2 . 

1 

School of Medicine, Duke University, Durham, 

NC; 2 Ophthalmology and Pediatrics, Duke 

University, Durham, NC *CR 

Moderators: Leonard A. Levin, Robert W. Nickells 

and M Francesca Cordeiro 

4938 — 2:45 Ocular Hypotensive and 

Neuroprotective Effects of Agmatine. Samin 

Hong. Ophthalmology, Yonsei University College 

of Medicine, Seoul, Republic of Korea 

4939 — 3:00 The Jigsaw Effect: Clinical 

Evidence for CNS Control of Visual Field Loss 

in Chronic Glaucoma. Willliam E. Sponsel 1, 2 , 

N. Satsangi 3 , M. A. Reilly 1 , S. L. Groth 4 , S. J. 

McKinnon 5 . 1 Biomedical Engineering, University 

of Texas - San Antonio, San Antonio, TX; 

2 

Madison Square Bldg Ste 306, WESMDPA, San 

Antonio, TX; 3 School of Medicine, University of 

Texas Health Science Center - San Antonio, San 

Antonio, TX; 4 School of Medicine, University of 

Minnesota, Minneapolis, MN; 5 Ophthalmology and 

Neurobiology, Duke University, Durham, NC *CR 

4940 — 3:15 AAV-Mediated Neurotrophin-4 

Is Neuroprotective In Murine Model 

Of Microbead-Induced Glaucoma with 

Neurotrophin Expression in the Visual Pathway. 

Anna M. Demetriades, L. Guo, C. Pan. Glaucoma 

Research Laboratory, Weill Cornell Medical 

College, New York, NY 

4941 — 3:30 The Effect of Modulators of 

Microtubule Stability on Dendritic Morphology 

in Cultured Retinal Ganglion Cells. Rachel 

Chong 1 , B. Lorber 1 , K. R. Martin 1, 2 . 1 John Van 

Geest Centre for Brain Repair, University of 

Cambridge, Cambridge, United Kingdom; 2 NIHR 

Biomedical Research Centre, University of 

Cambridge, Cambridge, United Kingdom 

4942 — 3:45 Enhanced retinal ganglion 

cell survival in glaucoma by hypoxic 

postconditioning after disease onset. Yanli Zhu 1 , 

L. Zhang 1 , C. Chiang 2 , J. Gidday 1 . 1 Neurosurgery, 

Washington Univ Sch of Med, St Louis, MO; 

2 

Radiology, Washington Univ Sch of Med, St. 

Louis, MO 

4943 — 4:00 Neuroprotection from excitotoxic 

RGC death: is there a role for MMPs? Lies 

De Groef, M. A. Salinas-Navarro, E. Dekeyster, 

K. Lemmens, D. Gaublomme, I. Van Hove, L. K. 

Moons. Department of Biology, Laboratory for 

Neural Circuit Development and Regeneration, KU 

Leuven, Leuven, Belgium 

4944 — 4:15 TrkB Receptor Agonists as 

Neuroprotective Molecules in Glaucoma -Effect 

of 7,8 Dihydroxyflavone. Stuart Graham 1, 2 , Y. 

You 1 , J. C. Li 1 , V. Gupta 1 . 1 Australian School of 

Advanced Medicine, Macquarie University, Sydney, 

NSW, Australia; 2 Save Sight Institute, Sydney 

University, Sydney, NSW, Australia 

Moderator: R.V. Paul Chan 

4945 — 2:45 Length of daylight during early 

gestation is an independent predictor of risk 

for severe retinopathy of prematurity. Michael 

B. Yang 1, 2 , S. Rao 1 , D. R. Copenhagen 3, 4 , R. A. 

Lang 1, 2 . 1 Ophthalmology/Visual Systems Group/ 

Abrahamson Pediatric Eye Institute, Cincinnati 

Children’s Hospital Medical Center, Cincinnati, 

OH; 2 Ophthalmology, University of Cincinnati, 

Cincinnati, OH; 3 Ophthalmology, University of 

California San Francisco, San Francisco, CA; 

4 

Physiology, University of California San Francisco, 

San Francisco, CA *CR 

4946 — 3:00 Long term outcomes of lens 

clarity following lens-sparing vitrectomy for 

retinopathy of prematurity. Eric Nudleman, A. 

Capone, K. A. Drenser, M. T. Trese. Associated 

Retinal Consultants, William Beaumont Hospital, 

Royal Oak, MI *CR 

4947 — 3:15 Risk factors for retinopathy of 

prematurity (ROP): insights from “outlier” 

infants with low or high birth weights. Alexander 

D. Port 1 , R. Chan 2 , S. Ostmo 3 , M. F. Chiang 3, 4 . 

1 

Weill Cornell Medical College, New York, NY; 

2 

Ophthalmology, Weill Cornell Medical College, 

New York, NY; 3 Ophthalmology, Oregon Health 

& Science University, Portland, OR; 4 Medical 

Informatics and Clinical Epidemiology, Oregon 

Health & Science University, Portland, OR *CR 

4948 — 3:30 The postnatal weight-gain 

algorithm WINROP early identifies sight 

threatening retinopathy of prematurity in 

a nation based cohort of extremely preterm 

infant. Pia Lundgren 1, 2 , E. Stoltz Sjöström 3 , M. 

Domellöf 3 , G. Holmström 4 , A. Hård 2 , C. Lofqvist 2 , 

A. Hellström 2 . 1 Ophthalmology, Umeå University, 

Umeå, Sweden; 2 Ophthalmology, Sahlgrenska 

academy at University of Gothenburg, Gothenburg, 

Sweden; 3 Pediatrics, Umeå University, Umeå, 

Sweden; 4 Ophthalmology, Uppsala University, 

Uppsala, Sweden *CR 

4949 — 3:45 Detection of Threshold 

Retinopathy of Prematurity using the PINT-ROP 

Growth Model. Anupam Kumar, D. Morrison. 

Vanderbilt University School of Medicine, 

Nashville, TN *CR 

4950 — 4:00 Feasibility of Color Doppler 

Spectral Domain Optical Coherence 

Tomography in premature infants undergoing 

Retinopathy of Prematurity screening. Ramiro 

S. Maldonado 1 , E. L. Yuan 1 , D. Tran-Viet 1 , S. F. 

Freedman 1, 2 , D. Wallace 1, 2 , H. C. Hendargo 3 , 

J. A. Izatt 3 , C. A. Toth 1, 3 . 1 Duke University Eye 

Center, Durham, NC; 2 Pediatrics, Duke University 

School of Medicine, Durham, NC; 3 Biomedical 

Engineering, Duke University, Durham, NC *CR 

6E 


Retina 

461 Retinal Detachment II 

Moderators: Toshinori Murata and 

Ron A. Adelman 

4952 — 2:45 The Management of Retinal 

Detachments in Patients with Severe Mental 

Disabilities. Kirk H. Packo 1 , J. M. Civantos 1 , J. A. 

Cohen 1 , J. S. Pollack 1 , P. T. Merrill 1 , S. de Bustros 1 , 

B. Garretson 2 . 1 Ophthalmology, Rush University 

Medical Center, Chicago, IL; 2 Ophthalmology, 

Oakland University William Beaumont School of 

Medicine, Royal Oak, IL *CR 

4953 — 3:00 Management of Uncomplicated 

Retinal Detachments: A Multicenter Study. Ron 

A. Adelman 1 , A. Parnes 1 , D. Ducournau 2 . 1 Ophthal 

& Visual Science, Yale Univ Sch of Medicine, New 

Haven, CT; 2 Clinique Sourdille, Nantes, France 

4954 — 3:15 Primary Scleral Buckling: 

A Safe and Effective Treatment Option for 

Retinal Detachment. Frank Ruda 1 , A. Jirgis 2, 3 , 

N. Jabbour 1, 2 . 1 West Virginia University Eye 

Institute, Morgantown, WV; 2 ForSight Foundation, 

Morgantown, WV; 3 National Eye Institute - Cairo, 

Cairo, Egypt 

4955 — 3:30 Quantifying the Effects of 

Enzymatic Vitreolysis Reveals Biomechanical 

Roles of Structural Macromolecules in Shear 

and Extension. Benjamen Filas, Q. Zhang, Y. Shui, 

D. C. Beebe. Ophthalmology and Visual Sciences, 

Washington University School of Medicine, St. 

Louis, MO *CR 

4956 — 3:45 Traditional versus Extreme 

Pneumatic Retinopexy. Darin R. Goldman, C. P. 

Shah, J. S. Heier. Retina, Ophthalmic Consultants 

of Boston, Boston, MA *CR 

4957 — 4:00 Pediatric Rhegmatogenous 

Retinal Detachment Surgery by Segmental 

Scleral Bucking: Risk Factors and Anatomical 

Outcomes. Sidath E. Liyanage, M. Errera, R. 

Moya, S. Wong, E. Ezra. Vitreoretinal Department, 

Moorfields Eye Hospital, London, United Kingdom 

4958 — 4:15 Prophylactic Treatments for 

Retinal Tears/Detachment in Stickler Syndrome: 

Single Institution Experience. Kiran Turaka, S. 

Bryan, A. J. Gordon, H. M. Kwong, C. H. Sell. 

Retina, Associated Retina Consultants Ltd, Phoenix, 

AZ 

Wednesday Papers 

Minisymposium 

2:45 pm – 4:30 pm 


319


609 


Lens 

462 Lens Proteins/Physical Chemistry 

Moderators: Suraj P. Bhat and Jayanti Pande 

4959 — 2:45 Presence of αA-crystallin and 

αB-crystallin as two Independent Proteins in 

the Developing Ocular Lens: Evidence from 

Transmission Electron Microscopy. Rajendra K. 

Gangalum 1 , J. Horwitz 1 , S. A. Kohan 3 , I. Dighe 1 , 

S. P. Bhat 1, 2 . 1 Ophthalmology, Jules Stein Eye 

Institute, UCLA, Los Angeles, CA; 2 Molecular 

Biology Institute @ UCLA, Los Angeles, CA; 

3 

Brain Research Insitute, Los Angeles, CA 

4965 — 4:15 Statistical-thermodynamic 

model for charge-regulation properties of 

bovine γB-crystallin. George M. Thurston 1 , M. 

Martini 1, 3 , C. W. Wahle 2 , D. Hollenbeck 1 , D. S. 

Ross 2 , J. F. Hamilton 2 . 1 Physics, Rochester Institute 

of Technology, Rochester, NY; 2 Mathematics, 

Rochester Institute of Technology, Rochester, 

NY; 3 Physics, University of Illinois at Urbana- 

Champaign, Urbana-Champaign, IL 

TCC LL 4/5 


Genetics 

464 Advances in Ocular Genetics 

Moderators: Janey L. Wiggs and Edwin M. Stone 

4971 — 2:45 Transgenic TBK1 mouse develops 

signs of normal tension glaucoma. John H. 

Fingert 1 , K. A. Miller 1 , F. Solivan-Timpe 1 , B. Roos 1 , 

A. L. Robin 2 , R. F. Mullins 1 , M. G. Anderson 3 . 

1 

Ophthalmology, University of Iowa, Iowa City, IA; 

2 

Ophthalmology and International Health, Johns 

Hopkins University, Baltimore, MD; 3 Physiology, 

University of Iowa, Iowa City, IA *CR 

4972 — 3:00 Dominant-negative RBP4 

mutations cause congenital eye malformations 

through a maternal-fetal nutritional interaction. 

Tom M. Glaser 1, 2 , C. Chou 2 , S. A. Tarle 2 , J. Pribila 4 , 

T. Bardakjian 5 , A. S. Schneider 5 , C. C. Nelson 3 , T. 

M. Glaser 1, 2 . 1 Cell Biology & Human Anatomy, 

Univ of California, Davis School of Medicine, 

Davis, CA; 2 Human Genetics, Univ Michigan, Ann 

Arbor, MI; 3 Ophthalmology, Univ Michigan, Ann 

Arbor, MI; 4 Pediatric Ophthalmology, Park Nicollet 

Hospital, Lincoln Park, MN; 5 Genetics, Albert 

Einstein Medical Center, Philadelphia, PA 

4973 — 3:15 Non-exomic and synonymous 

variants in ABCA4 are an important cause 

of Stargardt disease. Edwin M. Stone 1, 2 , B. A. 

Tucker 1 , T. A. Braun 1 , R. F. Mullins 1 , A. H. Wagner 1 , 

S. G. Jacobson 3 , A. V. Cideciyan 3 , B. L. Lam 4 , G. A. 

Fishman 5 . 1 Department of Ophthalmology, Institute 

for Vision Research, University of Iowa, Iowa City, 

IA; 2 Howard Hughes Medical Institute, Iowa City, 

IA; 3 Department of Ophthalmology, Scheie Eye 

Institute, University of Pennsylvania, Philadelphia, 

PA; 4 Department of Ophthalmology, Bascom 

Palmer Eye Institute, University of Miami, Miami, 

FL; 5 Chicago Lighthouse for People Who Are Blind 

or Visually Impaired, Chicago, IL *CR 

4974 — 3:30 Application of Whole-Exome 

and Retinal-Capture Next-Generation DNA 

Sequencing to Identify Disease-Causing 

Mutations in Families with a Diagnosis of 

Autosomal Dominant Retinitis Pigmentosa. 

Stephen P. Daiger 1 , L. S. Sullivan 1 , S. J. Bowne 1 , 

G. M. Weinstock 2 , D. C. Koboldt 2 , R. Chen 3 , J. R. 

Heckenlively 4 , K. E. Branham 4 , D. G. Birch 5 , D. 

K. Wheaton 5 . 1 Human Genetics Center, School of 

Public Health, The Univ. of Texas Health Science 

Center, Houston, TX; 2 The Genome Institute, 

Washington University, St. Louis, MO; 3 Dept. of 

Molecular and Human Genetics, Baylor College of 

Medicine, Houston, TX; 4 Kellogg Eye Center, Univ. 

of Michigan, Ann Arbor, MI; 5 Retina Foundation of 

the Southwest, Dallas, TX *CR 


Minisymposium 

2:45 pm – 4:30 pm 

4960 — 3:00 Targeted disruption of lens 

αA-crystallin in Zebrafish (Danio Rerio). 

Hassane S. Mchaourab, P. Zou, W. Chen. Molec 

Physiol&Biophys-Med Ctr, Vanderbilt University, 

Nashville, TN 

4961 — 3:15 Surface-enhanced Raman 

spectroscopy (SERS) of gamma crystallins: A 

promising technique to study the redox reactions 

of cysteine residues in dilute protein solutions. 

Jayanti Pande 1 , J. A. Gomez-Santos 2, 1 , A. Pande 1 . 

1 

Department of Chemistry, University at Albany- 

SUNY, Albany, NY; 2 Department of Chemistry, 

Universidad Industrial de Santander, Bucaramanga, 

Colombia 

4962 — 3:30 Identification and Spatial 

Localization of Ocular Lens Age- and Cataract- 

Specific Protein Signatures. Kevin L. Schey 1, 2 , 

K. M. Rose 1 , D. M. Anderson 1 . 1 Biochemistry, 

Vanderbilt University, Nashville, TN; 

2 

Ophthalmology and Visual Sciences, Vanderbilt 

University, Nashville, TN 

4963 — 3:45 Expression and Distribution 

of Thiol-Regulating Enzyme Glutaredoxin 2 

(Grx2) in Porcine Ocular Tissues. Xiaoli Tian 1 , 

B. P. Upadhyaya 1 , H. Wu 1 , M. F. Lou 1, 2 . 1 School 

of Veterinary Medicine and Biomedical Sciences, 

University of Nebraska-Lincoln, Lincoln, NE; 

2 

Redox Biology Center, University of Nebraska 

Lincoln, Lincoln, NE 

4964 — 4:00 Expression of K6W-mutant 

ubiquitin in human lens epithelial cells (HLEC) 

alters conformation and linkages of polyubiquitin 

chains. Allen Taylor 1 , K. Liu 1 , M. 

Chang 1 , B. E. Riley 2 , T. A. Shaler 3 , K. M. Rose 4 , 

K. L. Schey 4 , F. Shang 1 . 1 Nutrition &Vision Res- 

USDA-HNRCA, Tufts University, Boston, MA; 

2 

Elan Pharmaceuticals Inc, South San Francisco, 

CA; 3 Stanford Research Institute, Menlo Park, CA; 

4 

Mass Spectrometry Research Center, Vanderbilt 

University, Nashville, TN 

611-614 



463 Transplanted and Endogenous 

Cells as Effectors of Outer Retinal 

Repair - Minisymposium 

This Minisymposium will provide an overview of 

the emerging approaches for developing cell-based 

therapies to treat diseases of the outer retina. 

Moderators: David M. Gamm and 

Peter F. Hitchcock 


4966 — 2:50 Retinal Repair Following 

Transplantation of ES-Derived Photoreceptor 

Cells. Robin R. Ali. Div of Molecular Therapy, 


Kingdom 

4967 — 3:10 Directing the Adult RPE Stem 

Cell to Promote Retinal Repair. Sally Temple. 

Neural Stem Cell Institute, Rensselaer, NY *CR 

4968 — 3:30 Development of Cellular 

Therapies Using hESC-derived RPE. Dennis 

O. Clegg. Department of Molecular, Cellular and 

Developmental Biology, University of California 

Santa Barbara, Santa Barbara, CA *CR 

4969 — 3:50 The Production of Photoreceptors 

and RPE Cells from Adult Retinal Stem Cells. 

Derek Van Der Kooy. University of Toronto, 

Toronto, ON, Canada 

4970 — 4:10 Molecular Mechanisms 

Underlying Muller Glia Dedifferentiation and 

Proliferation During Regeneration Of The 

Damaged Zebra Fish Retina. David R. Hyde. Dept 

of Biological Sciences, University of Notre Dame, 

Notre Dame, IN 


320


4975 — 3:45 Rare and common variants in 

extracellular matrix gene fibrillin 2 (FBN2) 

are associated with inherited and age-related 

macular degeneration, respectively. Anand 

Swaroop 1 , R. Priya 1 , X. Zhan 2 , R. Fariss 1 , K. E. 

Branham 2 , E. Y. Chew 1 , D. Stambolian 4 , S. S. 

Bhattacharya 3 , J. R. Heckenlively 2 , G. Abecasis 2 . 

1 

N-NRL, Bldg 6, National Eye Institute, 

Bethesda, MD; 2 University of Michigan, Ann 

Arbor, MI; 3 Institute of Ophthalmology, London, 

United Kingdom; 4 University of Pennsylvania, 

Philadelphia, PA *CR 

4976 — 4:00 Exome sequencing in the midwestern 

Amish to identify rare variation 

influencing AMD. Jessica N. Cooke Bailey 1 , L. 

D’Aoust 1 , L. Jiang 1 , R. Laux 1 , A. Agarwal 1 , W. 

K. Scott 2 , M. A. Pericak-Vance 2 , J. L. Haines 1 . 

1 

Center for Human Genetics Research, Vanderbilt 

University Medical Center, Nashville, TN; 

2 

Hussman Institute of Human Genomics, Miller 

School of Medicine, University of Miami, Miami, 

FL *CR 

4977 — 4:15 Chipping Away At The Genetics 

of Age Related Macular Degeneration. Goncalo 

Abecasis 1 , M. C. Schu 3 , X. Zhan 1 , S. Arumugam 4 , 

J. Bragg Gresham 1 , L. Fritsche 2 . 1 University of 

Michigan, Ann Arbor, MI; 2 Institute of Human 

Genetics, University of Regensburg, Regensburg, 

Germany; 3 Boston University School of Medicine, 

Boston, MA; 4 Case Western Reserve University, 

Cleveland, OH *CR 

TCC 305 



Neuro-Ophthalmology / Visual Psychophysics / 

Physiological Optics 

465 Amblyopia: Neural Mechanisms 

and Treatment 

Moderators: Eileen E. Birch and 

Benjamin Thompson 

4978 — 2:45 Retinal genes and proteins 

associated with postnatal visual deprivation in 

rats. Melissa Meyer zu Horste 1, 2 , V. Prokosch- 

Willing 3 , H. Melkonyan 3 , T. Stupp 3 , S. Thanos 3 . 

1 

Ophthalmology, University Hospital of Duisburg- 

Essen, Essen, Germany; 2 Ophthalmology, 

Angiogenesis Laboratory, Massachusetts Eye and 

Ear Infirmary, Cambridge, MA; 3 Experimental 

Ophthalmology, School of Medicine, Westfalian- 

Wilhelms-University Muenster, Muenster, Germany 

4979 — 3:00 Concordance with occlusion 

therapy for childhood amblyopia. Michael P. 

Wallace 1 , C. E. Stewart 1 , M. J. Moseley 1 , D. A. 

Stephens 2 , A. R. Fielder 1 . 1 Optometry and Visual 

Science, City University, London, United Kingdom; 

2 

Mathematics and Statistics, McGill University, 

Montreal, QC, Canada f 

4980 — 3:15 Patching therapy for amblyopia, 

are we patching the wrong eye? Jiawei Zhou 1 , B. 

Thompson 2 , R. F. Hess 1 . 1 Ophthalmology, McGill 

University, Montreal, QC, Canada; 2 Optometry and 

Vision Science, University of Auckland, Auckland, 

New Zealand *CR 

4981 — 3:30 Binocular iPad Treatment 

for Amblyopia. Simone Li 1 , V. Subramanian 1 , 

L. To 2 , R. M. Jost 1 , S. Jost 1 , D. R. Stager 3 , L. 

Dao 4 , D. R. Stager 4 , E. E. Birch 1, 5 . 1 Pediatrics, 

Retina Foudation of the Southwest, Dallas, TX; 

2 

Schepens Eye Research Institute, Boston, MA; 

3 

Pediatric Ophthalmology and the Center for Adult 

Strabismus, Dallas, TX; 4 Pediatric Ophthalmology 

and Adult Strabismus, Plano, TX; 5 Ophthalmology, 

University of Texas Southwestern Medical Center, 

Dallas, TX *CR 

4982 — 3:45 Dichoptic perceptual learning 

induces visual cortex plasticity in adults 

with amblyopia. Jinrong Li 1, 2 , B. Thompson 3 , 

D. Deng 2 , L. Y. Chan 4 , M. Yu 1, 2 , R. F. Hess 5 . 

1 

Department of Optometry and Vision Science, 

Sun Yat-sen University, Guangzhou, China; 2 State 

Key Laboratory of Ophthalmology, Zhongshan 

Ophthalmic Center, Sun Yat-sen University, 

Guangzhou, China; 3 Optometry and Vision Science, 

University of Auckland, Auckland, New Zealand; 

4 

The Hong Kong Polytechnic University, The Hong 

Kong Polytechnic University, Hong Kong, China; 

5 

Department of Ophthalmology, McGill University, 


4983 — 4:00 Anodal tDCS Enhances the Effect 

of Binocular Therapy on Stereopsis in Adults 

with Amblyopia. Daniel P. Spiegel 1 , J. LI 2 , R. F. 

Hess 3 , W. D. Byblow 4 , L. To 5 , J. R. Cooperstock 6 , 

M. Yu 2 , B. Thompson 1 . 1 Department of Optometry 

and Vision Science, The University of Auckland, 

Auckland, New Zealand; 2 State Key Laboratory of 

Ophthalmology, Zhongshan Ophthalmic Center, 

Sun Yat-sen University, Guangzhou, China; 

3 

Department of Ophthalmology, McGill University, 

Montreal, QC, Canada; 4 Department of Sport and 

Exercise Science, The University of Auckland, 

Auckland, New Zealand; 5 Schepens Eye Research 

Institute, Boston, MA; 6 Department of Electrical 

and Computer Engineering, McGill University, 


4984 — 4:15 Attention deficits in human 

strabismic amblyopia measured via neural 

responses to texture-defined forms: A highdensity 

EEG mapping study. Chuan Hou 1 , A. 

Norcia 2 , P. Verghese 1 , S. P. McKee 1 . 1 The Smith- 

Kettlewell Eye Research Institute, San Francisco, 

CA; 2 Stanford University, Stanford, CA 

Wednesday Papers 

Minisymposium 

2:45 pm – 4:30 pm 


321



2:45 pm – 4:30 pm 



Biochemistry/Molecular Biology 

466 AMD II, BI 

Moderator: Alecia K. Gross 

4985 — A0114 Comparison of the Gene 

Expression by Haplogroups H and J: 

Implications for AMD (Age Related Macular 

Degeneration). Claudio A. Ramirez 1 , M. Chwa 1 , 

S. Atilano 1 , D. Malik 1 , J. Cáceres del Carpio 1 , 

M. Tarek 1 , S. Jazwinski 2 , M. V. Michael 2 , B. D. 

Kuppermann 1 , C. M. Kenney 1 . 1 Gavin Herbert Eye 

Institute, University of California, Irvine, Irvine, 

CA; 2 Tulane Center for Aging, Tulane University, 

New Orleans, LA *CR 

4986 — A0115 Hops Extract Xanthohumol 

Protects Visual Acuity and Function After Light 

Damage. Stephanie L. Foster, N. F. Henneman, 

M. A. Chrenek, C. B. Wright, J. H. Boatright. 

Ophthalmology, Emory Univ School of Med, 

Atlanta, GA 

4987 — A0116 Role of Apoptotic Regulatory 

Proteins in Retinoblastoma. Lata Singh 1 , S. 

Kashyap 1 , N. Pushker 2 , S. Sen 1 , S. Bakhshi 3 , A. 

Sharma 4 , N. Saini 5 , J. Kaur 6 . 1 Ocular Pathology, 

All India Institute of Medical Sciences, New 

Delhi, India; 2 Ophthalmology, All India Institute 

of Medical Sciences, New Delhi, India; 3 Medical 

Oncology, IRCH, All India Institute of Medical 

Sciences, New Delhi, India; 4 Ocular Microbiology, 

All India Institute of Medical Sciences, New Delhi, 

India; 5 Biochemistry, Institute of Genomics and 

Integrative Biology, Mall Road, New Delhi, India; 

6 

Ocular Biochemistry, All India Institute of Medical 

Sciences, New Delhi, India 

4988 — A0117 Comparison Study of IL-33 

Gene Expression in Haplogroup H, J, L, and K 

Cybrids. Thomas A. Vo 1 , M. Chwa 1 , S. Atilano 1 , 

D. Malik 1 , C. A. Ramirez 1 , J. Cáceres del Carpio 1 , 

S. Jazwinski 2 , M. V. Michael 2 , B. D. Kuppermann 1 , 

C. M. Kenney 1 . 1 Opthalmology, Gavin Herbert Eye 

Institute at UC Irvine, Irvine, CA; 2 Tulane Center 

for Aging at Tulane University, New Orleans, LA 

*CR 

4989 — A0118 Resveratrol Protects 

Human Retinal Pigment Epithelial Cells 

from Inflammatory Insults. R K. Kutty 1 , 

C. N. Nagineni 1 , W. Samuel 1 , T. Duncan 1 , C. 

Vijayasarathy 2 , C. Jaworski 1 , T. Redmond 1 . 

1 

National Eye Institute, National Institutes of 

Health, Bethesda, MD; 2 National Institute on 

Deafness and Other Communication Disorders, 

National Institutes of Health, Bethesda, MD 

4990 — A0119 Bone morphogenetic protein 

4 induces ID1 and ID3 transcription factors in 

trabecular meshwork cells. Avani A. Mody, R. 

J. Wordinger, A. F. Clark. Visual sicence /NTERI, 

UNTHSC, Fort Worth, TX *CR 

4991 — A0120 The proteolytic activity of 

HTRA1 is responsible for its pathological role 

in polypoidal choroidal vasculopathy. Sandeep 

Kumar 1, 2 , A. Jones 1, 2 , Z. Berriochoa 2 , S. Wang 2 , Y. 

Fu 1, 2 . 1 Moran Center for Translational Medicine, 

University of Utah, Salt Lake City, UT; 2 Dept of 


Utah, Salt Lake City, UT *CR 

4992 — A0121 Associations between Posterior 

Vitreous Detachment and Concentrations of 

Various Cytokines in Eyes with Age-related 

Macular Degeneration and Normal Control 

Eyes. Hidenori Takahashi 1 , X. Tan 2 , Y. Nomura 2 , 

A. Iriyama 2 , Y. Fujino 3 , Y. Okubo 1 , A. Sato 1 , 

M. Takezawa 1 , H. Kawashima 1 , Y. Yanagi 2 . 

1 

Ophthalmology, Jichi Medical University, 

Shimotsuke-shi, Japan; 2 Ophthalmology, University 

of Tokyo, Tokyo, Japan; 3 Ophthalmology, Tokyo 

KoseiNenkin Hospital, Tokyo, Japan 

4993 — A0122 Quantitative Proteomic 

Identification of Novel Interacting Partners 

for the Serine Protease Htra1. Lili Feng 1 , E. 

Kortvely 1 , A. Vogt 1 , K. Boldt 1 , M. Ueffing 1, 2 . 1 Center 

of Ophthalmology, University of Tuebingen, 

Tuebingen, Germany; 2 Research Unit for Protein 

Science, Helmholtz Zentrum München, Neuherberg, 

Germany 

4994 — A0123 Amyloid Beta 1- 42 Promotes 

NLRP3-inflammasome Activation In Retinal 

Pigmented Epithelial Cells. Matthew West 1 , 

F. Lamoke 1 , A. Montemari 2 , G. Parisi 3 , G. 

Ripandelli 3 , D. M. Marcus 4 , M. Bartoli 1 . 

1 

Department of Ophthalmology, Georgia Health 

Sciences University, Augusta, GA; 2 Department of 

Experimental Medicine and Pathology, University 

of Rome, Rome, Italy; 3 IRCCS Fondazione GB 

Bietti, Rome, Italy; 4 Southeast Retina Center, 

Augusta, GA *CR 

4995 — A0124 Conditional ablation of 

VEGFR-1 in photoreceptors induces retinal 

angiomatous proliferation: A transgenic mouse 

model of AMD. Ling Luo 1, 2 , X. Zhang 1 , S. K. Das 1 , 

H. Uehara 1 , T. Miya 1 , T. Olsen 1 , B. Archer 1 , Y. 

Fu 1 , W. Baehr 1 , B. K. Ambati 1 . 1 Moran eye center, 

University of Utah, Salt lake city, UT; 2 Department 

of Ophthalmology, The 306th hospital of PLA, 

China, Beijing, China *CR 

4996 — A0125 In-depth analysis of blood 

plasma proteome for discovery of age-related 

macular degeneration biomarkers. Se Joon 

Woo 1, 2 , H. Kim 3 , E. Suh 3 , J. Park 1, 2 , J. Ahn 1, 2 , 

D. Hwang 1, 2 , J. Lee 3 , K. Park 1, 2 , C. Lee 3, 4 . 

1 

Ophthalmology, Seoul National University 

College of Medicine, Seoul, Republic of Korea; 

2 

Ophthalmology, Seoul National University 

Bundang Hospital, Seongnam, Republic of Korea; 

3 

Theragnosis Research Center, Korea Institute of 

Science and Technology, Seoul, Republic of Korea; 

4 

Biomolecular Science, University of Science and 

Technology, Daejeon, Republic of Korea 

4997 — A0126 Post-Transcriptional Gene 

Interactions in Retinal Ischemia. Kalina 

Andreeva, M. Soliman, N. G. Cooper. Anatomical 

Sciences & Neurobiology, University of Louisville 

School of Medicine, Louisville, KY 

4998 — A0127 An In-Vitro Study of Wnt 

Pathway Modulation in Cybrid H and J 

Mitochondrial Haplogroups and the Possible 

Implications for Age-related Macular 

Degeneration. Payam Falatoonzadeh 1 , G. B. Woo 1 , 

N. Udar 1 , S. Atilano 1 , M. Chwa 1 , M. V. Michael 2 , S. 

Jazwinski 2 , C. M. Kenney 1 . 1 Ophthalmology, Gavin 

Herbert Eye Inst., UC Irvine, Irvine, CA; 2 Tulane 

Center for Aging, Tulane University, New Orleans, 

LA *CR 

4999 — A0128 Expression of VEGF-C, 

VEGF-D and their Cognate Receptors in 

Experimental Choroidal Neovascularization 

and Clinical AMD. Kameran Lashkari 1 , J. Ma 1 , 

G. Teague 1 , J. G. Arroyo 2 . 1 Schepens Eye Research 

Institute/ Massachusetts Eye & Ear, Harvard Med 

School, Boston, MA; 2 Beth Israel Deaconess 

Medical Center, Harvard Med School, Boston, MA 

*CR 

5000 — A0129 Mitochondrial DNA 

Damage Increases with Age-related Macular 

Degeneration in the RPE but not Neural 

Retina. Marcia R. Terluk 1 , L. M. Soukup 2 , S. R. 

Montezuma 1 , D. A. Ferrington 1 . 1 Ophthalmology 

and Visual Neurosciences, University of Minnesota, 

Minneapolis, MN; 2 Biology, University of St. 

Thomas, St. Paul, MN 

5001 — A0130 Oxidative Stress-Induced 

Necrosis in RPE Cells. Jakub Hanus 1 , W. C. 

Anderson 1 , P. Jin 3 , Q. Liu 4 , S. Wang 1, 2 . 1 Cell 

and Molecular Biology, Tulane University, New 

Orleans, LA; 2 Ophthalmology, Tulane University, 

New Orleans, LA; 3 Human Genetics, Emory 

University, Atlanta, GA; 4 Biochemistry, University 

of Texas Southwestern Medical Center, Dallas, TX 

*CR 

5002 — A0131 Phosphorylation Networks in 

Age-Related Macular Degeneration. Srinivas R. 

Sripathi 1 , O. Sylvester 2 , T. Moser 1 , P. S. Bernstein 3 , 

F. Lamoke 4 , M. Bartoli 4 , W. Jahng 2 . 1 Biological 

Sciences, Michigan Tech University, Houghton, 

MI; 2 Retina Proteomics Laboratory, Petroleum 

Chemistry, American University of Nigeria, Yola, 

Nigeria; 3 Ophthalmology and Visual Sciences, 

Moran Eye Center, University of Utah, Salt Lake 

City, UT; 4 Ophthalmology, Georgia Health Sciences 

University, Augusta, GA *CR 

5003 — A0132 Evaluation of RPE cell 

senescence as a mechanism for age-related 

macular degeneration (AMD),. Michael R. 

Kozlowski. Arizona College of Optometry, 

Midwestern University, Glendale, AZ 

5004 — A0133 An In-Vitro Study of the Effect 

of Ultraviolet Radiation on Growth Patterns and 

Gene Expression of Human ARPE-19 Cybrid H 

and J, and their Implications with Age-related 

Macular Degeneration (AMD). Deepika Malik 1 , 

P. Falatoonzadeh 1 , T. Hsu 1, 2 , C. A. Ramirez 1 , J. 

Cáceres del Carpio 1 , M. Mohamed Moustafa 1 , S. 

Jazwinski 3 , M. V. Michael 3 , C. M. Kenney 1 , B. D. 

Kuppermann 1 . 1 Ophthalmology, Gavin Herbert 

Eye Institute, Irvine, CA; 2 Warren Alpert Medical 

School, Brown University, Providence, RI; 3 Tulane 

Center for Aging, Tulane University, New Orleans, 

LA *CR 


322


5005 — A0134 Cybrids with Different mtDNA 

Haplogroups Show Differential Expression of 

Respiratory Complex Genes. Cristina M. Kenney 1 , 

M. Chwa 1 , S. Atilano 1 , P. Falatoonzadeh 1 , D. Malik 1 , 

C. A. Ramirez 1 , S. Jazwinski 2 , M. V. Michael 2 , B. 

D. Kuppermann 1 . 1 Ophthalmology, Gavin Herbert 

Eye Inst, UC Irvine, Irvine, CA; 2 Tulane Center for 

Aging, Tulane University, New Orleans, LA *CR 

5006 — A0135 The serine protease HTRA1 

is a potential regulator of the inflammatory 

cytokine GDF15. Chloe M. Stanton 1 , E. Kortvely 2 , 

C. Hayward 1 , M. Ueffing 2, 3 , A. F. Wright 1 . 1 MRC 

Human Genetics Unit, MRC IGMM, University 

of Edinburgh, Edinburgh, United Kingdom; 

2 

Centre for Ophthalmology, Institute for Opthalmic 

Research Tubingen, Tubingen, Germany; 3 Research 

Unit of Protein Science, Helmholtz Zentrum 

Munchen, Munich, Germany 

5007 — A0136 Role of complement in altered 

RPE function and deposit formation in Efemp1 

mutant mice: A primary cell culture model. 

Rosario Fernandez-Godino, E. A. Pierce, D. 

Garland. Ophthalmology, Ocular Genomics 

Institute. Mass Eye and Ear Infirmary. Harvard 


5008 — A0137 Quantifying progression of 

disease in aging mouse and human RPE. John 

M. Nickerson 1 , X. Qi 2 , T. Jiang 3 , Y. Cheng 3 , J. M. 

Zhang 3 , M. A. Chrenek 1 , A. Rashid 1 , S. K. Arora 1 , H. 

E. Grossniklaus 1 , Y. Jiang 2 . 1 Ophthalmology, Emory 

Univ, Atlanta, GA; 2 Mathematics, Georgia State 

University, Atlanta, GA; 3 Statistics, Yale University, 

New Haven, CT 

5009 — A0138 Zinc Staining of sub- 

RPE Deposits in Murine Models of Retinal 

Degeneration. Rebecca J. Kapphahn 1 , H. 

Roehrich 2 , D. A. Ferrington 1 , F. J. van Kuijk 1 . 

1 

Ophthalmology, University of Minnesota, 

Minneapolis, MN; 2 Histology Core for Vision 

Research, Universtiy of Minnesota, Minneapolis, 

MN 

5010 — A0139 VEGF, VEGF-C, and VEGF-D 

Increases in Aqueous Humor Samples in a LPS 

Induced Model of Uveitis in New Zealand White 

Rabbits. Douglas Decker, J. E. Burr, K. Lester, V. 

Zaworski, S. J. Weber. Biochemistry, PharmOptima, 

Portage, MI *CR 

5011 — A0140 The role of Cannabinoid 

receptors on light-induced photoreceptor 

degeneration. Tomoyo Imamura, Y. Ohno, 

K. Tsuruma, M. Shimazawa, H. Hara. Gifu 

Pharmaceutical University, Gifu, Japan 

5012 — A0141 The involvement of heparinbinding 

epidermal growth factor like growth 

factor on light-induced retinal degeneration. 

Yuki Inoue, T. Nakanishi, A. Oyagi, Y. Ohno, T. 

Otsuka, K. Tsuruma, M. Shimazawa, H. Hara. Gifu 

Pharmaceutical University, Gifu, Japan 

5013 — A0142 Comparison Study of EFEMP1 

Gene Expression Levels in Human ARPE-19 

Cybrid Models Having Mitochondrial DNA 

of Haplogroups H, J, K or L. Danli Xing 1 , D. 

Malik 1 , P. Falatoonzadeh 1 , S. Atilano 1 , M. Chwa 1 , 

S. Jazwinski 2 , M. V. Michael 2 , B. D. Kuppermann 1 , 

C. M. Kenney 1 . 1 Ophthalmology, UC Irvine, Long 

Beach, CA; 2 Tulane Center for Aging, Tulane 

University, New Orleans, LA *CR 

5014 — A0143 Inositol phosphatase INPP5E 

in primary cilia and eye development. Na Luo 1 , 

M. Conwell 1 , A. Kumar 1 , R. M. Anderson 2 , Y. Sun 1 . 

1 

Ophthalmology, Indiana University, Indianapolis, 

IN; 2 Pediatrics/Endocrinology, Indiana University, 


5015 — A0144 Human Complement Factor 

H (CFH) Transgene Expression Rescues the 

Visual Function and Retina Abnormalities in 

Aged cfh-/- Mice. Jindong Ding 1 , U. L. Kelly 1 , M. 

Groelle 1 , C. Bowes Rickman 1, 2 . 1 Ophthalmology, 


2 

Cell Biology, Duke University Medical Center, 

Durham, NC 

5016 — A0145 Casein Kinase 1 Epsilon Is 

Identified As A Potential Therapuetic Target For 

Dry AMD By A Multi-Pronged Gene Expression 

Approach. George Inana 1 , C. Murat 1 , M. J. 

McLaren 2 . 1 Ophthalmology, Bascom Palmer Eye 

Institute, Miami, FL; 2 Graymatter Research, Miami, 

FL *CR 




467 Visual Functions in AMD 

Moderator: Michael D. Crossland 

5017 — A0179 Preliminary assessment of a 

new device to test potential visual acuity when 

compared to gold standard PAM. Elizabeth R. 

Richter, J. A. Kylstra. Storm Eye Institute, Medical 

University of South Carolina, Charleston, SC *CR, 

f 

5018 — A0180 Evaluation of vision autotesting 

in patients with AMD using an iPad App. 

Matthias G. Hartmann. Private Practice, Berlin, 

Germany *CR 

5019 — A0181 A New Contour Integration 

Macular Perimetry (CIMP) on iPad for Visual 

Function Evaluation in Maculopathy. Yi-Zhong 

Wang 1, 2 , G. Mitzel 1 . 1 Retina Foundation of the 

Southwest, Dallas, TX; 2 Ophthalmology, UT 

Southwestern Medical Center, Dallas, TX *CR 

5020 — A0182 myVisionTrack (mVT), a novel 

remote visual self-assessment, correlates with 

clinical course of macular function. Yu-Guang 

He 1 , J. D. Warminski 1 , Y. Wang 2 . 1 Ophthalmology, 

Univ Texas Southwestern Med Ctr, Dallas, TX; 

2 

Retina Foundation of the Southwest, Dallas, TX 

*CR 

5021 — A0183 Visual Acuity Loss In 

Patients With AMD, Measured Using A 

Vanishing Optotype Letter Chart. Nilpa 

Shah 1 , R. S. Anderson 1, 2 , A. Tufail 1 , C. A. Egan 1 , 

S. Dakin 1 . 1 NIHR Biomedical Research Centre 

for Ophthalmology, Moorfields Eye Hospital & 


Kingdom; 2 Vision Science Research Group, School 

of Biomedical Sciences, University of Ulster at 

Coleraine, Northern Ireland, United Kingdom *CR 

5022 — A0184 Screening for AMD Using 

Psychophysical Correlates of Macular 

Dysfunction. Han Li 1 , S. M. Culican 2 . 1 Washington 

University School of Medicine, St. Louis, MO; 

2 

Dept of Ophthalmology and Visual Science, 

Washington University School of Medicine, St. 

Louis, MO 

5023 — A0185 A New Method to Depict 

Central Scotomas: Automated Sterocampimetry. 

Anthony P. Cappo 1 , R. B. Rosen 2 , W. H. Seiple 3 , M. 

D. Orr 1 , M. Arthurs 4 , T. Emborgo 5 . 1 Opticology, 

Inc., New York, NY; 2 New York Eye & Ear 

Infirmary, New York, NY; 3 Lighthouse International, 

New York, NY; 4 Universite de Montreal, Montreal, 

QC, Canada; 5 Hunter College, City University of 

New York, New York, NY *CR 

5024 — A0186 Spaeth/Richman Contrast 

Sensitivity Test in Macular Degeneration. Bruno 

M. Faria, F. Duman, M. Ali, C. Zangalli, S. S. 

Wizov, L. Lu, J. Richman, E. Spaeth, G. L. Spaeth. 

Glaucoma, Bruno Faria, Philadelphia, PA *CR, f 

5025 — A0187 Central And Paracentral 

Single-Letter Recognition In Eyes With Macular 

Lesions. Gianfrancesco M. Villani 1 , L. Bertelli 1 , 

G. Sato 2 , M. U. Morales 3 , A. Colenbrander 4 . 

1 

Ophthalmology, Centro Riabilitazione Ipovedenti e 

Microperimetria - CRIM, Castel d’Azzano, Verona, 

Italy; 2 UO Oftalmologia, Centro Riabilitazione 

Visiva, Ospedale S. Antonio, Ulss16, Padova, Italy; 

3 

Ophthalmology and Visual Sciences, School of 

Clinical Sciences, The University of Nottingham, 

Nottingham, United Kingdom; 4 Smith-Kettlewell 

Eye Research Institute, San Francisco, CA *CR 

5026 — A0188 Longitudinal Changes in Retinal 

Sensitivity among Patients with Maculopathy. 

Hongting Liu, M. G. Bittencourt, O. O. Agbedia, A. 

Moradi, Y. J. Sepah, D. A. Ferraz, M. A. Ibrahim, 

R. Sophie, M. Ansari, Q. Nguyen. Retinal Imaging 

Research and Reading Center, Wilmer Eye Institute 

Johns Hopkins University, Baltimore, MD *CR 

5027 — A0189 Monitoring the Progression 

of AMD post anti-VEGF treatment using the 

OPKO OCT/SLO. michele arthurs 1 , R. B. Rosen 3 , 

G. Landa 3 , R. Weitz 3 , W. H. Seiple 2, 3 . 1 Université 

de Montréal, Montréal, QC, Canada; 2 New York 

Lighthouse, New York, NY; 3 New York Eye & Ear 

Infirmary, New York, NY *CR, f 


2:45 pm – 4:30 pm 


323



2:45 pm – 4:30 pm 

5028 — A0190 Relationship between 

Visual Function and Optical Coherence 

Tomography features in Early Age-related 

macular degeneration (AMD)-Early Markers 

Observational Study. Ruth E. Hogg 1 , G. Murphy 1 , 

G. Staurenghi 2 , C. Rosina 2 , R. Silva 3 , A. Santos 3 , 

U. Chakravarthy 1 . 1 Center for Vision and Vascular 

Science, Queen’s University Belfast, Belfast, United 

Kingdom; 2 Eye Clinic - Department of Clinical 

Science, “Luigi Sacco”- Sacco Hospital, II School 

of Ophthalmology - University of Milan, Milan, 

Italy; 3 Faculty of Medicine., University of Coimbra, 

Coimbra, Portugal *CR 

5029 — A0191 Relationship between retinal 

sensitivity and retinal thickness in eyes with 

retinal disease. Srinivas R. Sadda, M. Nittala. 

Ophthalmology, Doheny Eye Institute - USC, Los 


5030 — A0192 Multimodal Evaluation of 

Macular Function in Age-related Macular 

Degeneration. Ken Ogino, A. Tsujikawa, K. 

Yamashiro, S. Ooto, A. Oishi, I. Nakata, M. Miyake, 

A. Takahashi, A. A. Ellabban, N. Yoshimura. Kyoto 

University Graduate School of Medicine, Kyoto, 

Japan *CR 

5031 — A0193 The functional impact of 

subfoveal SD-OCT characteristic on reading 

acuity in neovascular age related macular 

degeneration. Florian Sulzbacher 1 , C. G. Kiss 1 , S. 

Sacu 1 , M. R. Munk 1 , A. Kaider 2 , T. Mittermueller 1 , P. 

K. Roberts 1 , U. Schmidt-Erfurth 1 . 1 Ophthalmology, 

Medical University Vienna, Vienna, Austria; 2 Center 

for Medical Statistics, Informatics, and Intelligent 

Systems; Section for Clinical Biometrics;, Medical 

University of Vienna, Vienna, Austria *CR 

5032 — A0194 Dark-adapted Microperimetry 

In Age-related Maculopathy And Geographic 

Atrophy. Michael D. Crossland 1, 2 , R. Ba-Abbad 1, 2 , 

S. Degli Esposti 2 , A. Tufail 2, 3 , G. S. Rubin 1, 3 . 

1 

UCL Institute of Ophthalmology, London, 

United Kingdom; 2 Moorfields Eye Hospital NHS 

Foundation Trust, London, United Kingdom; 

3 

NIHR Moorfields Biomedical Research Centre for 

Ophthalmology, London, United Kingdom *CR 

5033 — A0195 Development of a Dark 

Adaptation Protocol for Use in AMD Clinical 

Trials. Gregory R. Jackson 1 , J. G. Edwards 2 . 

1 

Ophthalmology, Penn State College of Medicine, 

Hershey, PA; 2 MacuLogix, Hershey, PA *CR 

5034 — A0196 High Angular Resolution 

Peripheral Refraction in Patients with Age 

Related Macular Degeneration. Bart Jaeken 2, 1 , 

E. Alcón 1, 3 , J. Marín 3 , P. Artal 1 . 1 Laboratorio de 

Optica, Universidad de Murcia, Murcia, Spain; 

2 

R&D, Voptica, Murcia, Spain; 3 Oftalmología, 

Hospital Virgen de la Arrixaca, Murcia, Spain *CR 

5035 — A0197 Compensation of fixational 

instability by the NIDEK MP-1 micro-perimeter. 

Arunkumar Krishnan, H. E. Bedell. University of 

Houston - College of Optometry, Houston, TX 

5036 — A0198 BCEA evaluation after pattern 

stimulation in wet AMD patients. Enzo M. 

Vingolo, P. G. Limoli, S. Fragiotta, V. De Rosa, D. 

Domanico. UOC Ophthal Hosp “SM Goretti” LT, 

University La Sapienza of Rome, Roma, Italy 

5037 — A0199 The Influence of Fixation 

Stability on Balance in Patients with a Central 

Scotoma. Caitlin Murphy 1, 4 , J. Chu 2 , E. Landy 2 , 

J. Campbell 2 , A. Phan 2 , O. Overbury 1, 3 . 1 School 

of Optometry, University of Montreal, Montreal, 

QC, Canada; 2 Physiotherapy, McGill University, 

Montreal, QC, Canada; 3 Ophthalmology, McGill 

University, Montreal, QC, Canada; 4 Centre for 

Interdisciplinary Research in Rehabilitation (CRIR), 

Montreal, QC, Canada 

5038 — A0200 Impact of Visual Motion 

Displayed in a Non-Immersive Head-Mounted 

Device on the Balance of Patients with Age- 

Related Macular Degeneration. Caroline 

Chauvire 1 , C. Cecilia 1 , A. Koustanai 1 , J. Le Brun 1 , 

S. Pineau 1 , T. Villette 2 , P. Chaumet-Riffaud 1, 3 , 

S. Mohand-Said 1 , J. A. Sahel 1 , A. B. Safran 1 . 

1 

INSERM, U968; UPMC Univ Paris 06, UMR_S 

968, Institut de la Vision; CNRS, UMR_7210; 

CHNO des Quinze-Vingts, INSERM-DHOS CIC 

503, Paris, France; 2 Essilor R&D International, 

Paris, France; 3 Univ Paris Sud, AP-HP, CHU 

Bicêtre, Paris, France *CR 

5039 — A0201 Comparing the fixational and 

functional preferred retinal locus. Brian Sullivan, 

L. Renninger. Smith-Kettlewell Eye Research 

Institute, San Francisco, CA 

5040 — A0202 Maximum Reading Speed and 

Binocular Summation in Patients with Central 

Vision Loss. Luminita Tarita-Nistor 1, 2 , E. G. 

Gonzalez 1, 2 , M. H. Brent 3, 4 , S. N. Markowitz 3, 4 , M. 

J. Steinbach 1, 2 . 1 Vision Science Research Program, 

Toronto Western Hospital, Toronto, ON, Canada; 

2 

Centre for Vision Research, York University, 

Toronto, ON, Canada; 3 Ophthalmology and 

Vision Sciences, University of Toronto, Toronto, 

ON, Canada; 4 Ophthalmology, Toronto Western 

Hospital, Toronto, ON, Canada 

5041 — A0203 Predictive Factors of Reading 

Performance Post Reading Rehabilitation 

Program in Central Field Loss Patients. 

Salvatore Di Lauro, M. B. Coco, A. López-Miguel, 

R. Cuadrado, A. Mayo, J. De Lázaro, M. J. 

Maldonado, J. Herrera, L. Mena, J. Pastor. Retina- 

Low Vision, IOBA Eye Institute, University of 

Valladolid, Valladolid, Spain *CR 

5042 — A0204 Do Pedestrians Make Safe 

Street-Crossing Decisions? Shirin E. Hassan. 

School of Optometry, Indiana University, 

Bloomington, IN 



Physiology/Pharmacology 

468 Drug Delivery III 

Moderators: Ashim K. Mitra and 

Uday B. Kompella 

5043 — B0001 A minimally invasive and 

localised intra-scleral delivery of drug-loaded 

thermoresponsive polymeric implants to treat 

posterior ocular diseases. Hannah L. McMillan, 

S. J. Fallows, T. R. Singh, D. S. Jones. School of 

Pharmacy, Queen’s University Belfast, Belfast, 


5044 — B0002 Hindered convective transport 

of nanoparticles and macromolecules in 

the vitreous humor. Anita N. Penkova 1, 2 , K. 

Rattanakijsuntorn 1 , Y. Tang 2 , R. Moats 2, 3 , M. R. 

Robinson 4, 2 , S. S. Lee 4, 2 , S. S. Sadhal 1, 2 . 1 Aerospace 

& Mechanical Engineering, University of Southern 

California, Los Angeles, CA; 2 SAIRC, Saban 

Research Center, Children’s Hospital Los Angeles, 

Los Angeles, CA; 3 Biomedical Engineering, 


CA; 4 Global Pharmaceutical Sciences, Allergan, 

Inc, Irvine, CA *CR 

5045 — B0003 Slow-release intraocular drug 

delivery by injectable PEA microfibrils (DSM, 

NL). Gabriele Thumann 1 , G. Mihov 2 , J. Thies 2 , A. 

Kemp 2 , K. Morawa 1 , M. Kropp 1 . 1 Department of 

Ophthalmology, University of Geneva, Geneva, 

Switzerland; 2 DSM, Geleen, Netherlands *CR 

5046 — B0004 Fucoidan but not Mannan 

inhibits Bevacizumab uptake independently 

of phagocytosis and reduces VEGF expression 

in the RPE. Michaela Dithmer 1 , T. Meyer 2, 3 , 

E. Richert 1 , J. Roider 1 , A. K. Klettner 1 . 

1 

Ophthalmology, University of Kiel, University 

Medical Center, Kiel, Germany; 2 Immunology, 

University of Kiel, University Medical Center, Kiel, 

Germany; 3 Medizinische Klinik I, Charite-Campus 

Benjamin Franklin, Berlin, Germany *CR 

5047 — B0005 In Vivo Pharmacokinetics 

of Injectable, Intravitreal, Sustained-Release 

Latanoprost Formulations. William S. White, M. 

Hu, G. Huang, T. Pham, F. Karasina, A. Lee, M. 

Gorlina, V. Wong. Icon Bioscience, Inc, Sunnyvale, 

CA *CR 

5048 — B0006 Hystem, a bio-absorbable 

protein delivery polymer: safety, tolerability and 

efficacy in a rabbit corneal debridement model. 

MaryJane Rafii 1 , B. M. Wirostko 1, 2 , L. Werner 2 , N. 

Mamalis 2 , T. Zarembinski 4 , S. Pritt 3 , G. G. Gum 3 . 

1 

Ophthalmics, Jade Therapeutics, Salt Lake City, 

UT; 2 Ophthalmology, University of Utah, SLC, UT; 

3 

Absorption Systems, SD, CA; 4 BioTime, Almeda, 

CA *CR 

5049 — B0007 Delivery of Human Growth 

Hormone via DSM’s Poly(ester amide). Julien 

Bérard 1 , J. Zupancich 1 , A. Hecka 1 , G. Mihov 1 , S. 

Reiver 1 , J. Thies 1 , K. A. Messier 1 , B. M. Wirostko 2 , 

M. Rafii 2 . 1 DSM, Geleen, Netherlands; 2 Jade 

Therapeutics, LLC, Salt Lake City, UT *CR 


324


5050 — B0008 Design of a Non-Invasive Coreshell 

Nanoparticulate Drug Delivery System for 

Posterior Part of the Eye. Binapani Mahaling, D. 

S. Katti. Biological Sciences and Bioengineering, 

Indian Institute of Technology Kanpur, Kanpur, 

India 

5051 — B0009 Development and 

characterization of silicone pressure sensitive 

adhesive episcleral implant. He Wen, S. Li. 

University of Cincinnati, Cincinnati, OH *CR 

5052 — B0010 Ocular injection characteristics 

and in vitro release profiles of lipophilic dye 

using thermogel PLGA-PE-PLGA as a sustainedrelease 

drug delivery device. Eva Abarca, P. M. 

Potter, J. H. Salmon, B. C. Gilger. North Carolina 

State University, Raleigh, NC *CR 

5053 — B0011 Development of Aqueous 

Nanomicellar Formulation for Topical Delivery 

of Biotinylated Lipid Prodrug of Acyclovir to 

Treat Herpetic Keratitis. Aswani Dutt Vadlapudi, 

K. Cholkar, R. Vadlapatla, A. K. Mitra. Division of 

Pharmaceutical Sciences, University of Missouri- 

Kansas City, Kansas City, MO 

5054 — B0012 Dexamethasone Sustained 

Delivery From Polyesteramide Microspheres 

For Intraocular Administration. Influence 

Of Sterilization. Vanessa Andres-Guerrero 1 , M. 

Zong 2 , G. Mihov 2 , A. A. Dias 2 , R. Herrero-Vanrell 1 . 

1 

Pharmaceutical Technology, Faculty of Pharmacy/ 

Complutense University, Madrid, Spain; 2 DSM, 

Geleen, Netherlands *CR 

5055 — B0013 Pharmacodynamic study 

of Intravitreal liposomal doxorubicin by 

matrix-assisted laser desorption/ionizationmass 

spectrometry (MALDI/MS). Hsi-Kung 

Kuo, Y. Chen, P. Wu. Ophthalmology, Kaohsiung 

Chang Gung Memorial Hospital and Chang Gung 

University College of Medicine, Kaohsiung, Taiwan 

5056 — B0014 Cavernous Sinus as Ocular 

Pharmacokinetic Compartment for Better 

Understanding of Posterior Segment and 

Contralateral Eye Drug Availability. Muhammad 

Abdulrazik. Ophthal/Innovative Interventions, East 

Jerusalem Biomedical Institute, East Jerusalem, 

Occupied Palestinian Territory 

5057 — B0015 Influence of Physicochemical 

Properties on Drug Delivery across Sclera into 

Choroid-Retina. Ayumi Yoshimatsu 1 , C. Yabuta 1 , 

A. Ohtori 1, 2 , M. Azuma 1 . 1 Senju Laboratory of 

Ocular Sciences, Senju Pharmaceutical Co., Ltd., 

Kobe, Japan; 2 Laboratory of Ocular Drug Delivery 

System, Kyushu Institute of Technology, Fukuoka, 

Japan *CR 

5058 — B0016 Sustained Prednisolone 

Acetate-loaded Microfilm Drug Delivery System 

Effectively Prolongs corneal allograft survival 

in the rat keratoplasty model. Yu-Chi Liu 1, 2 , Y. 

Peng 3 , N. Lwin 1 , S. Venkatraman 3 , T. Wong 1, 2 , J. 

S. Mehta 1, 2 . 1 Singapore Eye Research Institute, 

Singapore, Singapore; 2 Singapore National Eye 

Centre, Singapore, Singapore; 3 School of Materials 

Science and Engineering, Nanyang Technological 

University, Singapore, Singapore *CR 

5059 — B0017 Treatment of Acute Posterior 

Uveitis by Injection of Triamcinolone 

Acetonide into the Suprachoroidal Space Using 

Microneedles. Brian C. Gilger 1 , E. M. Abarca 1 , J. 

H. Salmon 1 , S. R. Patel 2 . 1 Clinical Sciences, North 

Carolina State University, Raleigh, NC; 2 Clearside 

Biomedical, Alpharetta, GA *CR 

5060 — B0018 Ocular and Systemic 

Pharmacokinetics of a PDE4 Inhibitor Following 

Topical Administration (Eyedrop) in Male 

Dutch-Belted Rabbits. David C. Gale 1 , C. J. 

Sychterz 2 , C. Rodgers 2 , S. Wang 2 , T. Wilde 2 , A. 

Krishnatry 2 , H. Ellens 2 . 1 Ophthalmology DPU, 

GlaxoSmithKline, King of Prussia, PA; 2 PTS 

DMPK-UM, GlaxoSmithKline, King of Prussia, 

PA *CR 

5061 — B0019 Aqueous humor concentration 

of Bromfenac 0.09% (Bromday) compared with 

Bromfenac in DuraSite 0.075% (Bromsite) in 

cataract patients undergoing phacoemulsification 

after 3 days dosing. Kamran Hosseini 1 , J. 

Hutcheson 1 , L. M. Bowman 2 . 1 Clinical, InSite Vision 

Inc, Alameda, CA; 2 Development, InSite Vision, 

Alameda, CA *CR, f 

5062 — B0020 Comparison of the Total 

Amount of Triamcinolone Acetonide 

Delivered Via Suprachoroidal or Intravitreal 

Administration. Brian Burke, R. S. Verhoeven, S. 

R. Patel. Clearside Biomedical, Raleigh, NC *CR 

5063 — B0021 Suprachoroidal Microinjection 

Delivers Triamcinolone Acetonide to 

Therapeutically-Relevant Posterior Ocular 

Structures and Limits Exposure in the Anterior 

Segment. Henry F. Edelhauser 1, 2 , S. R. Patel 2 , C. 

Meschter 3 , R. Dean 3 , K. Powell 4 , R. S. Verhoeven 2 . 

1 

Ophthalmology, Emory Univ Eye Center, 

Atlanta, GA; 2 Clearside Biomedical, Alpharetta, 

GA; 3 Comparative Biosciences, Sunnyvale, CA; 

4 

Tandem Labs, Durham, NC *CR 

5064 — B0022 Protective Effects of 

Transscleral Drug Delivery Device Against 

Photoreceptor Cell Death in S334ter Rhodopsin 

Mutant Rats. Nobuhiro Nagai 1 , H. Kaji 2 , H. 

Onami 1 , T. Yamada 2 , Y. Katsukura 1 , Y. Ishikawa 1 , 

M. Nishizawa 2 , Y. Mashima 3 , T. Abe 1 . 1 Graduate 

School of Medicine, Tohoku University, Sendai, 

Japan; 2 Graduate School of Engineering, Tohoku 

University, Sendai, Japan; 3 R-Tech Ueno, Tokyo, 

Japan *CR 

5065 — B0023 In vitro cytotoxicity screening 

and pharmacokinetic modeling: a tool in the 

development of ocular drug delivery systems. 

Eva Tuominen 1 , G. Mihov 2 , M. Zong 2 , S. Sarkhel 1 , 

A. A. Dias 2 , A. Urtti 1 . 1 Centre for Drug Research, 

Faculty of Pharmacy, University of Helsinki, 

Helsinki, Finland; 2 DSM, Geleen, Netherlands *CR 

5066 — B0024 Retinal Safety and Efficacy of 

a Dexamethasone Biodegradable Implant to 

Treat Macular Edema Associated to Retinal Vein 

Occlusion: A Phase I/II Clinical Trial. Rubens C. 

Siqueira 1 , R. B. Cunha 1 , A. Messias 1 , A. S. Cunha 2 , 

S. Fialho 2 , R. Jorge 1 . 1 Retina, Sao Paulo University, 

Sao Jose do Rio Preto, Brazil; 2 Pharmacology, 

Minas Gerais Federal University, Belo Horizonte, 

Brazil f 

5067 — B0025 Therapeutic effect of 

stealth-type polymeric nanoparticles with 

encapsulated cyclosporine A on experimental 

autoimmune uveoretinitis. Tsutomu Sakai 1 , K. 

Kuroyanagi 1 , T. Ishihara 2 , K. Okano 1 , H. Tsuneoka 1 . 

1 

Ophthalmology, Jikei Univ School of Medicine, 

Setagaya-ku, Japan; 2 Chemical biology and applied 

chemistry, Nihon university college of engineering, 

Kooriyama, Japan 

5068 — B0026 Development of an in vitro 

pharmacokinetic model of the human eye. 

Sahar Awwad 1, 2 , A. Lockwood 1, 2 , A. Mohamed 

Ahmed 1, 2 , G. Sharma 1, 2 , A. Khalili 2 , S. Brocchini 1, 2 , 

P. T. Khaw 2 . 1 UCL School of Pharmacy, London, 

United Kingdom; 2 National Institute for Health 

Research (NIHR) Biomedical Research Centre at 

Moorfields Eye Hospital NHS Foundation Trust and 


Kingdom *CR 

5069 — B0027 Tunable sustained intravitreal 

drug delivery system for daunorubicin using 

oxidized porous silicon. Huiyuan Hou 1 , A. 

Nieto 2 , F. Ma 1 , S. Lee 1 , K. Nan 1 , W. R. Freeman 1 , 

M. J. Sailor 2, 3 , L. Cheng 1 . 1 Department of 

Ophthalmology, Shiley Eye Center, UCSD, 

San Diego, CA; 2 Department of Chemistry and 

Biochemistry, UCSD, San Diego, CA; 3 Department 

of Bioengineering, UCSD, San Diego, CA *CR 

5070 — B0028 3D Computational Fluid 

Dynamic Simulation of an Intravitreal 

Brimonidine Implant in the Rabbit Eye. Julie 

E. Whitcomb 1 , S. S. Lee 2 , B. D. Swift 1 , J. Rowe 3 , 

M. R. Kazemi 4 , J. Shen 1 . 1 Pharmacokinetics 

& Drug Disposition, Allergan, Irvine, CA; 

2 

Ophthalmology Clinical Research, Allergan, Irvine, 

CA; 3 Bioanalytical Sciences, Allergan, Irvine, CA; 

4 

Independent Engineer Consultant, San Jose, CA 

*CR 

5071 — B0029 Optimization of In-vitro 

DiffER model to study/compare the effect 

of Formulations on Cross-Scleral transport 

of poorly aqueous soluble drug. Thomas E. 

Rowe 1 , K. W. Reed 2, 1 , T. Bhowmik 1 . 1 Encompass 

Pharmaceutical Services, Norcross, GA; 

2 

Pharmaceutical Sciences, Belmont University, 

Nashville, TN *CR 

5072 — B0030 Ocular bioavailability of 

brimonidine 0.1% BID in non-human primates. 

Chinatsu Tosha, S. Decker, G. Ruiz, O. Avalos, W. 

Orilla, L. Gruber, T. Lin, A. S. Almazan, D. W. Gil, 

J. A. Burke. Biological Science, Allergan, Inc., 

Irvine, CA *CR 

5073 — B0031 Sustained Delivery of 

Prostaglandin from Drug-Containing Depots 

Using Ocular Rings in Beagles. Kathryn S. 

Crawford 1 , J. Y. Ellis 2 , J. Rulander 3 , S. Johnston 3 , 

F. S. Lai 3 , E. J. Ellis 2 , C. D. Leahy 2 . 1 PharmOcu, 

Andover, MA; 2 Vista Scientific, LLC, Andover, 

MA; 3 Massachusetts Medical Device Development 

Center, University of Massachusetts, Lowell, MA 

*CR 

5074 — B0032 Evaluating & Predicting Drug 

Release from an Implantable Biomaterial. Ivana 

Postic, H. Sheardown. Chemical Engineering, 

McMaster University, Hamilton, ON, Canada *CR 


2:45 pm – 4:30 pm 


325



2:45 pm – 4:30 pm 

5075 — B0033 A hollow metal microneedle 

reduce reflux in intravitreal injections. SungHo 

Lee 1 , D. Lee 2 , Y. You 2 , S. Kim 2 , C. Lee 3 , H. Jung 3 , S. 

Lee 4 , O. Kwon 2 . 1 R&D Center, Lumieye Genetics 

Co., Ltd., Seoul, Republic of Korea; 2 Retina center, 

NUNE Eye Hospital, Seoul, Republic of Korea; 

3 

Biotechnology, Yonsei University, Seoul, Republic 

of Korea; 4 Ophthalmology, Soonchunhyang 

University Hospital, Seoul, Republic of Korea 




469 Dysfunction in Disease: 

Translational Studies 

Moderator: Erika D. Eggers 

5076 — B0034 Evidence Suggesting Retinotopic 

and Age Variability in Rate of Photoreceptor 

Loss Following Bright Light Exposure in 

Neonatal Rats. Anna Polosa, P. Lachapelle. 

Ophthalmology/Neurology-Neurosurgery, McGill 

University/Montreal Children’s Hospital, Montreal, 

QC, Canada 

5077 — B0035 Neonatal Hypoxia-Ischemia 

Retinopathy: Severity at Onset Determines 

Fate. Suna Jung 1, 2 , A. Polosa 2 , P. Lachapelle 2 , 

P. Wintermark 1 . 1 Newborn Medicine, Montreal 

Children’s Hospital, Montreal, QC, Canada; 

2 

Ophthalmology and Neurology-Neurosurgery, 

Research Institute of Montreal Children’s Hospital, 

McGill University, Montreal, QC, Canada 

5078 — B0036 Oxidative-Retinopathies: 

Female Neonate Rats Handle Bright Light 

Better Than Hyperoxia, Males React Strongly 

To Both. Samaneh Chaychi 1 , S. Chorfi 1 , A. Polosa 1 , 

S. Jung 1 , A. L. Dorfman 1 , X. Yang 1 , S. Chemtob 2 , 

P. Lachapelle 1 . 1 Ophthalmology-Neurology/ 

Neurosurgery, McGill Univ/Montreal Children’s 

Hosp, Montreal, QC, Canada; 2 Pharmacology, 

McGill Univ/Montreal Children’s Hosp, Montreal, 

QC, Canada 

5079 — B0037 Effects of vitamin A on a rat 

model of retinopathy of prematurity (ROP). Julie 

A. Mocko 1 , Y. Wei 2 , L. J. Frishman 1 , X. I. Couroucli 2 . 

1 

College of Optometry, University of Houston, 

Houston, TX; 2 Section of Neonatology, Department 

of Pediatrics, Baylor College of Medicine, Houston, 

TX 

5080 — B0038 Scotopic Spatial Summation 

in Retinopathy of Prematurity (ROP). Jena 

Tavormina 1, 2 , R. M. Hansen 1, 2 , A. Moskowitz 1, 2 , A. 

B. Fulton 1, 2 . 1 Ophthalmology, Boston Children’s 

Hospital, Boston, MA; 2 Harvard Medical School, 

Boston, MA 

5081 — B0039 Activation of Pannexin1 

channel induces ganglion cell loss in retinal 

ischemia. Valery I. Shestopalov 1, 2 , A. Toychiev 3 , 

G. Dvoriantchikova 1 , C. Yee 3 , A. Pronin 1, 4 , V. Z. 

Slepak 4 , B. T. Sagdullaev 3, 5 . 1 Bascom Palmer Eye 

Institute Dept. Ophthalmology, University of Miami 

Miller School of Medicine, Miami, FL; 2 Vavilov 

Institute of General Genetics, Moscow, Russian 

Federation; 3 Ophthalmology, Weill Medical College 

of Cornell University, White Plains, NY; 4 Molecular 

Pharmacology, University of Miami Miller School 

of Medicine, Miami, FL; 5 Winifred Masterson 

Burke Medical Research Institute, White Plains, NY 

5082 — B0040 Over-Expression of Dystrophin 

Isoform Dp71 Does Not Alter the Mouse ERG. 

De-Ann M. Pillers 1, 2 , W. Luo 1 , S. A. Tokarz 1 , P. N. 

Ray 4 , B. R. Pattnaik 1, 3 . 1 Department of Pediatrics, 

University of Wisconsin-Madison, Madison, WI; 

2 

McPherson Eye Research Institute, University of 

Wisconsin, Madison, WI; 3 Ophthalmology & Visual 

Science, University of Wisconsin, Madison, WI; 

4 

Hospital for Sick Children, University of Toronto, 

Toronto, ON, Canada 

5083 — B0041 Reduction of ERG Amplitude 

during light adaptation in Pikachurin nullmutant 

mice. Masatoshi Nagaya 1 , S. Ueno 1 , M. 

Kondo 2 , T. Furukawa 3 , H. Terasaki 1 . 1 Nagoya 

University, Nagoya, Japan; 2 Mie Univ Graduate 

School of Med, Tsu, Japan; 3 Institute for Protein 

Research, Osaka & JST, CREST, Osaka, Japan 

5084 — B0042 Alterations in the mGluR6 

signaling complex in the retina of mdx 3Cv mice, 

a model of Duchenne Muscular Disease. Michel 

J. Roux 1 , A. Philipps 1 , C. Chapot 1 , J. A. Sahel 2, 3 , A. 

Rendon 2 . 1 Translational Medicine & Neurogenetics, 

IGBMC, CNRS UMR7104 - Université de 

Strasbourg, Inserm U964, Illkirch, France; 

2 

Institut de la Vision, Inserm UMR_S968, CNRS 

UMR_7210, Université Pierre et Marie Curie 

Paris 06, Paris, France; 3 Centre d’Investigation 

Clinique 503, Inserm-Centre Hospitalier National 

d’Ophtalmologie des Quinze-Vingts, Paris, France 

*CR 

5085 — B0043 Evaluation of retinal and optic 

nerve stress in Wfs1-/- mouse model of Wolfram 

syndrome. Delphine M. Bonnet Wersinger 1 , C. P. 

Hamel 1 , Y. Tanizawa 2 , G. Lenaers 1 , C. Delettre 1 . 

1 

Montpellier Neuroscience Institute, INSERM 

U1051, Montpellier, France; 2 Center for Reparative 

Medicine Graduate School of Medicine, Yamaguchi 

University, Yamaguchi, Japan 

5086 — B0044 Impaired Functional 

Connectivity in the Visual Pathway in Monkeys 

Deficient in Omega-3 Fatty Acids. Martha 

Neuringer 1 , D. S. Grayson 2 , C. D. Kroenke 1, 3 , L. 

Renner 1 , A. R. Weiss 1 , D. A. Fair 2, 3 . 1 Neuroscience, 

Oregon National Primate Research Center, 

Beaverton, OR; 2 Behavioral Neuroscience, 

Oregon Health & Science University, Portland, 

OR; 3 Advanced Imaging Research Center, Oregon 

Health & Science University, Portland, OR *CR 

5087 — B0045 A novel knock-in model for 

the Y141C pattern dystrophy mutation in RDS. 

Michael Stuck, S. M. Conley, M. I. Naash. Univ of 

Oklahoma Hlth Sci Ctr, Oklahoma City, OK 

5088 — B0046 Elucidation of 

physiopathological mechanisms of GPR179. 

Elise Orhan 1 , L. Prezeau 5 , C. Michiels 1 , C. Vol 5 , 

J. A. Sahel 2, 3 , I. S. Audo 4, 3 , C. Zeitz 1 . 1 Institut de 

la Vision, Univ Pierre et Marie Curie Paris 6, 

INSERM, UMR_S968; CNRS, UMR_7210, Paris , 

F-75012, France; 2 Univ Pierre et Marie Curie Paris 

6, INSERM, UMR_S968; CNRS, UMR_7210; 

CHNO, INSERM-DHOS CIC 503; Fondation 

Ophtalmologique Adolphe de Rothschild, Paris; 

Académie des Sciences-Institut de France, Paris , 

F-75012, France; 3 UCL-Institute of Ophthalmology, 

11-43 Bath Street, London EC1V 9EL, United 

Kingdom; 4 Univ Pierre et Marie Curie Paris 6, 

INSERM, UMR_S968; CNRS, UMR_7210; 

CHNO, INSERM-DHOS CIC 503, Paris , F-75012, 

France; 5 Institut de Génomique Fonctionnelle 

CNRS UMR5203, INSERM U661, UM1 & UM2, 

Montpellier, France *CR 

5089 — B0047 Dry Eye and Headache Mouse 

Clinical Models of Photophobia. Anna Matynia 1, 2 , 

S. Parikh 1, 2 , A. Charles 2, 3 , M. B. Gorin 1, 2 . 1 Jules 

Stein Eye Institute, UCLA, Los Angeles, CA; 

2 

Brain Research Institute, UCLA, Los Angeles, CA; 

3 

Neurology, UCLA, Los Angeles, CA *CR 

5090 — B0048 Intravitreal injection of 

acyclovir causes dose-related retinal toxicity in 

rabbits. Gabriela L. Ioshimoto 1 , B. Takahashi 2 , C. 

N. Pessoa 3 , A. M. Liber 1 , B. V. Nagy 1 , D. F. Ventura 1 , 

F. Damico 2 . 1 Department Experimental Psychology, 

Psychology Institute, University of Sao Paulo, São 

Paulo, Brazil; 2 Department of Ophthalmology, 

University of Sao Paulo, Sāo Paulo, Brazil; 

3 

Department of Cell and Developmental Biology, 

Biomedical Sciences Institute, University of Sao 

Paulo, São Paulo, Brazil 

5091 — B0049 Retinal Degeneration in the 

Royal College of Surgeons Rat - A Study on 

Electrophysiological Properties. Stephan Hesse 1 , 

C. Haselier 1 , S. Johnen 1 , T. Baltz 2 , G. Roessler 1 , 

B. A. Mazinani 1 , P. Walter 1 . 1 Department of 

Ophthalmology, RWTH Aachen University, Aachen, 

Germany; 2 Department of Technical Science and 

Business Development, University of Erfurt, Erfurt, 

Germany *CR 

5092 — B0050 Light-evoked Response 

Recordings from Degenerating Mouse 

Retina: Effect of Valproic Acid Application on 

Spontaneous Activity. Jun Kaneko, M. Mandai, M. 

Takahashi. Lab for Retinal Regeneration, RIKEN 

Ctr for Developmental Biol, Kobe, Japan 

5093 — B0051 Retinal Inhibitory Signaling is 

Increased in Streptozotocin-induced Diabetes. 

Johnnie Moore-Dotson 1 , R. Mazade 1 , A. S. 

Berstein 1, 2 , M. J. Romero-Aleshire 1 , H. Brooks 1 , E. 

D. Eggers 1, 2 . 1 Physiology, University of Arizona, 

Tucson, AZ; 2 Biomedical Engineering, University 

of Arizona, Tucson, AZ 

5094 — B0052 The retinal phenotype of an 

animal model of the HANAC syndrome. Alix 

Trouillet 1 , E. Plaisier 2 , H. Lorach 1 , J. Dégardin 1 , M. 

Simonutti 1 , M. Paques 1 , J. A. Sahel 1 , P. Ronco 2 , S. 

A. Picaud 1 . 1 Institut de la Vision, INSERM/CNRS/ 

UPMC/CHNO des XV-XX, Paris, France; 2 APHP- 

Hôpital Tenon, Paris, France *CR 


326


5095 — B0053 Visual Deficits in Mice after 

Mild Traumatic Brain Injury Produced using 

A Novel Closed-head Model of Primary 

Overpressure Blast. Tonia S. Rex 1 , A. J. Elberger 2 , 

Y. Deng 2 , N. H. Guley 2 , J. Hines-Beard 1 , L. 

D’Surney 2, 3 , N. Del Mar 2 , M. G. Honig 2 , A. 

Reiner 2, 3 . 1 Ophthalmology & Visual Sciences, 

Vanderbilt University, Nashville, TN; 2 Anatomy 

& Neurobiology, University of Tennessee Health 

Science Center, Memphis, TN; 3 Ophthalmology, 

University of Tennessee Health Science Center, 

Memphis, TN *CR 

5096 — B0054 Morphological and Functional 

Study of Retinal Astrocytes in DBA/2J Mice. 

Laura Fernandez-Sanchez 1 , L. Perez de Sevilla 

Muller 2 , N. Brecha 2, 3 , N. Cuenca 1 . 1 Physiology, 

Genetics & Microbiology, University of Alicante, 

Alicante, Spain; 2 Neurobiology, David Geffen 

School of Medicine at UCLA, Los Angeles, CA; 

3 

Veterans Administration, Greater Los Angeles 

Healthcare System, Los Angeles, CA *CR 

5097 — B0055 Axonal Transport Disruption 

in Retinal Ganglion Cells Following Transient 

Increase in Intraocular Pressure. Andrea C. 

Nuschke 1, 2 , X. Wang 1, 2 , N. O’Leary 1, 3 , C. A. 

Smith 1, 2 , B. C. Chauhan 1, 3 . 1 Retina and Optic Nerve 

Research Laboratory, Dalhousie University, Halifax, 

NS, Canada; 2 Physiology and Biophysics, Dalhousie 

University, Halifax, NS, Canada; 3 Ophthalmology 

and Visual Sciences, Dalhousie University, Halifax, 

NS, Canada 

5098 — B0056 VLC-PUFA and the scotopic 

photoresponse. Lea D. Marchette 1 , R. A. Radu 2 , R. 

E. Anderson 1 . 1 Ophthalmology, Univ of Oklahoma 

Hlth Sci Ctr, Oklahoma City, OK; 2 UCLA, Los 


5099 — B0057 Implantation of a highdensity, 

flexible CMOS imaging sensor retinal 

prosthesis in minipig eyes. Chang-Hao Yang 1 , 

L. Fan 2 , F. Yang 2 . 1 Ophthalmology, National 

Taiwan Univ Hospital, Taipei, Taiwan; 2 Institute 

of NanoEngineering and Microsystems, National 

Tsing-Hua University, Hsinchu, Taiwan *CR 

5100 — B0058 Development and Evaluation 

of Highly Light-Sensitive Channelrhodopsin-2 

Mutants for Vision Restoration. Zhuo-Hua 

Pan, T. Ganjawala, Z. Zhang, Q. Lu, E. Ivanova. 

Ophthalmology and Anatomy & Cell Biology, 

Wayne State Univ Sch of Med, Detroit, MI *CR 




470 Dysfunction in Disease: 

Clinical Studies 

Moderator: Carol A. Westall 

5101 — B0059 Wide field imaging in patients 

treated with vigabatrin. Catherine Brugniart 1 , 

J. Bursztyn 2 , J. Motte 3 , A. Ducasse 1 , C. F. Arndt 1 . 

1 

Ophtalmologie, CHU Reims, Reims, France; 

2 

Cabinet Ophtalmologie, Paris, France; 3 American 

Memorial Hospital, Reims University Hospital, 

Reims, France *CR 

5102 — B0060 Association Between ERG 

Associated Vigabatin Toxicity and Subsequent 

Visual Field Reduction. Ananthavalli 

Kumarappah 1, 2 , Y. Reginald 2 , J. Buncic 2 , O. 

Snead 3 , C. A. Westall 1, 2 . 1 Institute of Medical 

Sciences, University of Toronto, Toronto, ON, 

Canada; 2 Ophthalmology and Vison Sciences, The 

Hospital for Sick Children, Toronto, ON, Canada; 

3 

Neurology, The Hospital for Sick Children, 

Toronto, ON, Canada *CR 

5103 — B0061 Electroretinograms Ordered 

for Vigabatrin Use at the Children’s Hospital 

Colorado. Ashley E. Laing 1 , J. L. Jung 1 , E. A. 

McCourt 1, 2 , R. S. Braverman 1, 2 . 1 Ophthalmology, 

University of Colorado, Denver, CO; 

2 

Ophthalmology, Children’s Hospital of Colorado, 

Aurora, CO 

5104 — B0062 Absence of the cone-mediated 

OP 3 

associated with Vigabatrin therapy. Julie 

Racine, R. Noles, J. R. Hickox, M. McGregor, D. 

L. Rogers. Ophthalmology, Nationwide Children’s 

Hospital, Columbus, OH 

5105 — B0063 The utility of multifocal 

electroretinography (mfERG) in screening 

for hydroxychloroquine/chloroquine induced 

retinopathy. Kevin Leonard, J. Gao, J. Hamilton, 

C. Gottlieb, S. G. Coupland. University of Ottawa 

Eye Institute, Ottawa, ON, Canada *CR 

5106 — B0064 Follow-up of patients affected 

by rheumathoid arthritis and connectivities, 

under therapy with hydroxychloroquine or 

chloroquine via multifocal electroretinogram, 

frequency doubling technology, automated 

perimetry, optical coherence tomography and 

autofluorescence. Giulio Ruberto 1 , L. Cavagna 2 , 

C. Tinelli 3 , M. Raimondi 1 , V. Mogavero 1 , P. 

Piccinini 1 , F. Borgaro 1 , L. Bossolesi 1 . 1 Clinica 

Oculistica, IRCCS Policlinico San Matteo, Pavia, 

Italy; 2 reumatologia, IRCCS Policlinico San 

Matteo, Pavia, Italy; 3 Servizio di biometria, IRCCS 

Policlinico San Matteo, Pavia, Italy 

5107 — B0065 Evaluation of Inner Retinal 

Changes using Macular Focal Electroretinogram 

and Optical Coherence Tomography in Patients 

with Early Stage Diabetes. Manami Kuze 1, 2 , T. 

Tanaka 3 , H. Goto 3 , M. Kondo 2 . 1 Ophthalmology, 

NHO Mie Chuo Medical Center, Tsu, Japan; 

2 

Ophthalmology, Mie University School of 

Medicine, Tsu, Japan; 3 Internal Medicine, NHO Mie 

Chuo Medical Center, Tsu, Japan 

5108 — B0066 Relation between the fast 

oscillation of the EOG and ERG measures of 

rod photoreceptor function in healthy eyes and 

in diabetes. Marilyn E. Schneck, W. A. Verdon, W. 

Lam, K. P. Dhamdhere, T. Zeng, S. Barez, M. A. 

Bearse, A. J. Adams. School of Optometry-2020, 

UC Berkeley, Berkeley, CA 

5109 — B0067 PRPH2 Mutations as a Cause 

of Electronegative ERG. Rola Ba-Abbad 3, 1 , A. G. 

Robson 1, 4 , A. T. Moore 4, 2 , A. R. Webster 4, 2 , Y. Yap 2 , 

G. E. Holder 1, 3 . 1 Electrophysiology, Moorfields 

Eye Hospital, London, United Kingdom; 2 Medical 

Retina & Genetics, Moorfields Eye Hospital, 

London, United Kingdom; 3 Visual Neuroscience, 

Institute of Ophthalmology, London, United 

Kingdom; 4 Genetics, Institute of Ophthalmology, 


5110 — B0068 Long-Term Decay of Central 

Cone Function in Cone-Rod Dystrophy 

Evaluated by Focal Electroretinogram. Benedetto 

Falsini 1 , M. Piccardi 1 , L. Ziccardi 2 , A. Fadda 4 , A. 

M. Minnella 1 , D. Marangoni 1 , S. Bisti 6 , G. Resta 5 , L. 

Galli Resta 3 . 1 Ophthalmology, Universita’ Cattolica 

del S. Cuore, Rome, Italy; 2 Ophthalmology, Bietti 

Foundation IRCCS, Rome, Italy; 3 Neuroscience 

Institute, CNR, Pisa, Italy; 4 Health and Technology, 

Istituto Superiore di Sanita, Rome, Italy; 

5 

Informatics and Telematics, CNR, Pisa, Italy; 

6 

Scienze Cliniche ed Applicate Biotecnologiche, 

Universita dell’Aquila, L’Aquila, Italy 

5111 — B0069 Blue-on-yellow 

electroretinography on patients with enhanced 

S-cone syndrome. Kazuki Kuniyoshi 1 , T. Hayashi 2 , 

H. Sakuramoto 1 , H. Tsuneoka 2 , Y. Shimomura 1 . 

1 

Ophthalmology, Kinki University Faculty of 

Medicine, Osaka-sayama, Japan; 2 Ophthalmology, 

The Jikei University School of Medicine, Tokyo, 

Japan 

5112 — B0070 Chromatic Full-field Stimulus 

Threshold (FST) in Retinitis Pigmentosa - 

Relationships with electroretinography and 

visual field outcomes. Andre Messias, K. Messias, 

R. S. Arcieri, V. M. Castro, R. C. Siqueira, R. Jorge. 

Ophthalmology, University of Sao Paulo, Ribeirao 

Preto, Brazil 


2:45 pm – 4:30 pm 


327



2:45 pm – 4:30 pm 

5113 — B0071 Microvolt Cone 

Electroretinography in Type 1 and 2 Usher 

Syndrome. Wadih M. Zein 1 , E. T. Tsilou 1 , A. 

E. Turriff 1 , J. M. Schultz 3 , J. A. Muskett 4 , C. 

C. Brewer 4 , C. K. Zalewski 4 , K. A. King 4 , P. A. 

Sieving 2, 5 , B. Falsini 1, 6 . 1 Ophthalmic Genetics 

& Visual Function, NEI/NIH, Bethesda, MD; 

2 

National Eye Institute/NIH, Bethesda, MD; 

3 

Laboratory of Molecular Genetics, National 

Institute on Deafness and Other Communication 

Disorders (NIDCD)/NIH, Rockville, MD; 

4 

Otolaryngology Branch, National Institute on 

Deafness and Other Communication Disorders 

(NIDCD)/NIH, Rockville, MD; 5 National Institute 

on Deafness and Other Communication Disorders 

(NIDCD)/NIH, Rockville, MD; 6 Ophthalmology, 

Catholic University of Sacred Heart, Rome, Italy f 

5114 — B0072 Population receptive field 

estimates in V1 lesion projection zone of 

patients with macular degeneration onset at 

different ages. Yoichiro Masuda 1, 2 , M. Terao 3 , T. 

Haji 4 , K. Amano 5, 6 , H. Horiguchi 1, 7 , S. Ogawa 1, 7 , 

I. Murakami 3 , K. Matsumoto 4 , H. Tsuneoka 1 , B. 

Wandell 7 . 1 Ophthalmology, Jikei Univ School of 

Med, Tokyo, Japan; 2 Ophthalmology, Atsugi City 

Hospital, Kanagawa, Japan; 3 Department of Life 

Sciences, The University of Tokyo, Tokyo, Japan; 

4 

Brain Science Institute, Tamagawa University, 

Tokyo, Japan; 5 Graduate School of Frontier 

Sciences, The University of Tokyo, Tokyo, Japan; 

6 

PRESTO, Japan Science and Technology Agency, 

Tokyo, Japan; 7 Psychology, Stanford University, 

Stanford, CA 

5115 — B0073 Visual Function Effects of 

Foretinib, a Dual MET/VEGFR2 Inhibitor, 

in a Phase 2 Study for Treatment of Papillary 

Renal Cell Carcinoma. Catherine Meyerle 1 , R. 

Srinivasan 2 , W. Linehan 2 , S. Yeh 1 , E. Y. Chew 1 , C. 

Chan 1 , F. Forooghian 1 , F. L. Ferris 1 , W. M. Zein 1 . 

1 

National Eye Institute, Bethesda, MD; 2 National 

Cancer Institute, Bethesda, MD *CR, f 

5116 — B0074 Anatomical Locus of Spatial 

Summation within the Retina and Neuroretinal 

Disease. Katherine Boudreault 1 , L. A. Levin 2, 3 . 

1 

Ophthalmology, University of Montreal, Montreal, 

QC, Canada; 2 Ophthalmology, McGill University, 

Montreal, QC, Canada; 3 Ophtalmology, University 

of Wisconsin, Madison, WI *CR 

5117 — B0075 Combined Systemic Health 

Markers are Associated with Multifocal 

Electroretinogram Implicit Times in Healthy 

Subjects with no Eye Disease. Wendy W. 

Harrison, V. Yevseyenkov, C. Sorenson. Optometry, 

Midwestern Univ Arizona Coll of Optometry, 

Glendale, AZ 

5118 — B0076 Differences in neuroretinal 

function between healthy adult males and 

females under and over the age of 50 years. 

Glen Y. Ozawa 1 , M. A. Bearse 1 , W. W. Harrison 2 , 

K. W. Bronson-Castain 1 , M. E. Schneck 1 , S. Barez 1 , 

K. P. Dhamdhere 1 , B. E. Wolff 1 , A. J. Adams 1 . 

1 

UC Berkeley School of Optometry, Berkeley, 

CA; 2 Midwestern University Arizona College of 

Optometry, Glendale, AZ 

5119 — B0077 Analysis of electroretinograms 

performed from 2009 to 2011 at Children’s 

Hospital Colorado. Jennifer L. Jung 1 , A. E. 

Laing 1 , E. A. McCourt 2, 1 , R. S. Braverman 2, 1 . 

1 

Ophthalmology, University of Colorado, Aurora, 

CO; 2 Ophthalmology, Children’s Hospital Colorado, 

Aurora, CO 

5120 — B0078 Electroretinographic assessment 

of retinal function at high altitude. Andreas 

Schatz 1 , G. Willmann 1 , M. Fischer 1, 2 , K. Schommer 3 , 

A. Messias 4 , E. Zrenner 1 , K. Bartz-Schmidt 1 , F. 

Gekeler 1 . 1 Centre for Ophthalmology, University 

of Tuebingen, Tuebingen, Germany; 2 Department 

of Clinical Neurosciences, University of Oxford, 

Oxford, United Kingdom; 3 Department of Sports 

Medicine, University of Heidelberg, Heidelberg, 

Germany; 4 Department of Ophthalmology, School 

of Medicine of Ribeirão Preto-University of São 

Paulo, São Paulo, Brazil *CR 

5121 — B0079 Unilateral Post Operative Visual 

Loss with Total Ophthalmoplegia due to central 

retinal artery occlusion following Cervical Spine 

surgery in Prone Position. Vishal Jindal 1 , A. Raj 1 , 

D. Kapoor 2 . 1 Ophthalmology, GMCH, Chandigarh, 

India; 2 Anesthesia, GMCH, Chandigarh, India 

5122 — B0080 A study on visual status 

in children with autistic spectral disease at 

Shraddha Center in Hyderabad City. Shata 

Roopa Reddy Pebbeti 1, 2 , K. Challa 1 , G. D. Vatti 1 , 

P. Jagana 1 , G. K. Vemuganti 1 . 1 School of Medical 

Sciences, University of Hyderabad, Hyderabad, 

India; 2 Brienholden Vision Institute, University of 

New South Wales, Sydney, NSW, Australia 

5123 — B0081 Prognostic Value of Photopic 

Negative Response in Retinal Vein Occlusion 

after Anti-VEGF treatment. Tae Kwann 

Park, J. Hyun, S. An, Y. Ohn. Ophthalmology, 

Soonchunhyang Univ Hospital, Bucheon-si, 


5124 — B0082 Electronretinogram and 

aqueous vascular endotheril growth factor in 

the eyes with hemi-central retinal vein occlusion 

or branch retinal vein occlusion. Shu Kachi, S. 

Yasuda, H. Ushida, M. Kondo, S. Ueno, C. Piao, 

H. Terasaki. Ophthalmology, Nagoya University, 

Nagoya, Japan 

5125 — B0083 Central retina vein occlusion 

and diabetic retinopathy treated with intravitreal 

dexamethasone and bevacizumab: a morphofunctional 

analysis. Sara Lombardo, M. Imparato, 

G. Ruberto, V. Mogavero, L. Giannì, F. Marzi, A. 

Amisano, A. Bianchi, P. Bianchi, G. Vandelli. Eye 

Clinic, IRCCS Policlinico San Matteo, Pavia, Italy 

5126 — B0084 Retinal blood flow levels 

measured by Laser Speckle Flowgraphy in 

central retinal vein occlusion as a predictive 

factor for ischemia and visual loss. Makiko 

Matsumoto, K. Suzuma, Y. Yamada, E. Tsuiki, A. 

Fujikawa, T. Kitaoka. Ophthalmology, Department 

of Ophthalmology and Visual Sciences, Graduate 

School of Biomedical Sciences, Nagasaki 

University, Nagasaki, Japan 

5127 — B0085 ERG as Indicator of Retinal 

Function in Persistent Fetal Vasculature. Brian 

Do 1 , J. H. Francis 2 , B. Marr 2 , D. H. Abramson 2 , 

S. E. Brodie 1, 2 . 1 Ophthalmology, The Mount Sinai 

School of Medicine, New York, NY; 2 Ophthalmic 

Oncology, Memorial Sloan Kettering Cancer 

Center, New York, NY 

5128 — B0086 Electrophysiological Test for 

the Assessment of Dysfunction in Glaucoma. 

Momoyo K. Menz, M. G. Fendick, E. E. Sutter. 

Electrophysiology Laboratory, Electro-Diagnostic 

Imaging, Inc, Redwood City, CA *CR 

5129 — B0087 Relationship between amplitude 

of N2 of multifocal electroretinograms and 

retinal sensitivity in unilateral glaucoma 

patients. Gen Miura, S. Shirato, S. Yamamoto. 

Chiba university, Chiba, Japan 

5130 — B0088 Alteration of Photopic Negative 

Response of Multifocal Electroretinogram in 

Patients with Glaucoma. Muneyoshi Kaneko, 

S. Machida, Y. Hoshi, D. Kurosaka. Department 

of Ophthalmology, Iwate Medical University, 

Morioka, Japan 

5131 — B0089 Reproducibility of Multifocal 

Visual Evoked Potential (mfVEP) in Normal and 

Multiple Sclerosis (MS) Eyes. Divya Narayanan, 

H. Cheng, R. Tang, L. J. Frishman. Optometry, 


5132 — B0090 Rates of Reliable Multifocal 

Visual Evoked Potential Waveforms: 

Comparison Between Multiple Sclerosis and 

Neuromyelitis Optica Patients. Lorena B. Botelho 

Vergara 1, 2 , P. A. Paixao 1, 2 , L. A. Fernandes 1, 2 , 

E. C. Lacerda 2, 3 , G. S. Souza 2, 3 , A. L. Moura 4 , 

D. F. Ventura 4 , H. Souza Cabeça 5 , A. A. Rosa 2, 6 , 

L. L. Silveira 2 . 1 Instituto de Ciencias da Saude, 

Universidade Federal do Para, Belem, Brazil; 

2 

Nucleo de Medicina Tropical, Universidade Federal 

do Para, Belem, Brazil; 3 Instituto de Ciencias 

Biologicas, Universidade Federal do Para, Belem, 

Brazil; 4 Instituto de Psicologia, Universidade de 

Sao Paulo, Belem, Brazil; 5 Hospital Ophyr Loiola, 

Belem, Brazil; 6 Hospital Univesitario Bettina Ferro 

de Souza, Belem, Brazil 

5133 — B0091 Patients with severe 

impairment in one eye show improved 

performance to defocus-induced blur. Trisevgeni 

Giannakopoulou 1 , S. Plainis 1, 2 , J. Moschandreas 3 , 

I. G. Pallikaris 1 , M. K. Tsilimbaris 1 . 1 Institute of 

Vision and Optics (IVO), University of Crete, 

Heraklion, Crete, Greece; 2 Faculty of Life Sciences, 

The University of Manchester, Manchester, United 

Kingdom; 3 Department of Social Medicine, 

University of Crete, Heraklion, Crete, Greece 


328





471 Retinal Development II: Retina 

and Vasculature 

Moderator: Xiuqian Mu 

5134 — B0138 Analysis of Cell Death Pathways 

in Developing Retina. Shuai Li 1 , P. G. Fuerst 1, 2 . 

1 

Neuroscience, University of Idaho, Moscow, ID; 

2 

WWAMI Medical Education Program, University 

of Idaho, Moscow, ID 

5135 — B0139 Axin2 Disruption Causes Ocular 

Defects During Mouse Eye Development. Sabine 

Fuhrmann, M. Gibbons, A. Alldredge. Ophthal & 

Vis Sci, University of Utah, Salt Lake City, UT 

5136 — B0140 Mechanisms of retinal bipolar 

cell genesis in Blimp1 (Prdm1) mutant mice. 

Joseph A. Brzezinski 1 , K. Park 1 , T. A. Reh 2 . 

1 

Ophthalmology, University of Colorado Denver, 

Aurora, CO; 2 Biological Structure, University of 

Washington, Seattle, WA 

5137 — B0141 Disruption of ocular 

development and function in Prickle 1 (Pk1) 

mutant mouse. Chunqiao Liu 1 , H. Qian 2 , A. 

Swaroop 1 , T. Li 1 . 1 Neurobiology Neurodegeneration 

& Repair Laboratory (N-NRL), National Eye 

Institute, Bethesda, MD; 2 Visual Function Core, 

National Eye Institute, Bethesda, MD 

5138 — B0142 Role of HDACS in the 

development and maintenance of the retinal 

ganglion cell layer in chick retina. Ankita Saha, T. 

L. Belecky-Adams. Department of Biology Center 

for Regenerative Biology and Medicine, Indiana 

University Purdue University at Indianapolis, 

Indianapolis, IN 

5139 — B0143 Pattern of Protein 

Phosphorylation in Wild Type and Rd1 Mouse 

Retina. Ju Zhang, J. M. Ogilvie. Saint Louis 

University, Saint Louis, MO 

5140 — B0144 Calcium binding proteins 

neuroplasticity in vertebrate retinas exposed to 

dim light. Nicolas S. Fosser, A. R. Paganelli, H. 

Rios. Instituto de Biologia Celular y Neurociencias, 

Facultad de Medicina, Universidad de Buenos 

Aires, Buenos Aires, Argentina 

5141 — B0145 The Matricellular Protein 

CCN1 is Required for Growth, Maturation and 

Stabilization of the Retinal Vasculature. Chintala 

Hemabindu 1 , J. Choi 1 , J. Shan 1 , M. B. Grant 2 , 

B. Chaqour 1 . 1 Cell Biology and Ophthalmology, 

SUNY Downstate Medical Center, Brooklyn, NY; 

2 

Pharmacology and Therapeutics, University of 

Florida, Gainesville, FL 

5142 — B0146 Blood Vessel Pattern in 

Subjects with Albinism. Miriam Ehrenberg 1 , R. 

M. Hansen 1, 2 , A. Moskowitz 1, 2 , A. B. Fulton 1, 2 . 

1 

Department of Ophthalmology, Boston Children’s 

Hospital, Boston, MA; 2 Harvard Medical School, 

Boston, MA 

5143 — B0147 The expression of nestin during 

the vascular development in mouse retina. Yong 

Woo Kim 1, 2 , D. Jo 2 , H. Jun 2 , J. Kim 2 , J. Kim 1, 2 . 

1 

Department of Ophthalmology, Seoul National 

University College of Medicine, Seoul National 

University Hospital, Seoul, Republic of Korea; 

2 

Fight against Angiogenesis-Related Blindness 

(FARB) Laboratory, Clinical Research Institute, 

Seoul National University Hospital, Seoul, Republic 

of Korea 

5144 — B0148 Development of the Rodent 

Inner Blood-Retinal-Barrier. Ewa C. Kubala 1 , R. 

J. Mrsny 3 , L. Paneghetti 1 , D. T. Shima 1, 2 . 1 Institute 


London, United Kingdom; 2 National Institute for 

Health Research Biomedical Research Centre, 

Moorfields Eye Hospital NHS Foundation Trust 

and UCL Institute of Ophthalmology, London, 

United Kingdom; 3 Department of Pharmacy and 

Pharmacology, University of Bath, Bath, United 

Kingdom *CR 

5145 — B0149 Role of the Early Ocular 

Vasculature in Regulation of Retinal 

Neurogenesis. Susov Dhakal 1 , C. B. Stevens 1 , O. 

Weiss 2 , A. Inbal 2 , D. L. Stenkamp 1 . 1 Department of 

Biological Sciences, University of Idaho, Moscow, 

ID; 2 Department of Medical Neurobiology, The 

Hebrew University of Jerusalem, Jerusalem, Israel 

5146 — B0150 A simple method for the 

isolation, purification and cultivation of retinal 

microvascular pericytes from rat. Xiaoling Liu 1, 2 , 

G. Liu 1, 3 , C. Meng 4 , M. Pan 3 , Y. Zheng 3 , L. Lin 4 , L. 

Zhao 5 . 1 School of Optometry and Ophthalmology 

and Eye Hospital, Wenzhou Medical College, 

Wenzhou, China; 2 State Key Laboratory 

Cultivation Base and Key Laboratory of Vision 

Science,Ministry of Health P.R. China, Wenzhou, 

China; 3 Department of Ophthalmology, Affiliated 

People’s Hospital, Fujian University of Traditional 

Chinese Medicine, Fuzhou, China; 4 Department of 

Bioengineering, College of Biological Science and 

Biotechnology, Fuzhou University, Fuzhou, China; 

5 

Department of Cardiology, Affiliated People’s 

Hospital, Fujian University of Traditional Chinese 

Medicine, Fuzhou, China 

5147 — B0151 Expression of the Axonal 

Guidance Receptors EPHA5 and EPHA6 

Changes Across Retinal Development. Krista M. 

Beach 1 , H. M. Queener 1 , T. Kiyama 2 , S. W. Wang 2 , 

D. C. Otteson 1 . 1 Optometry, University of Houston, 

Houston, TX; 2 Ophthalmology & Visual Science, 

Unviersity of Texas Medical School, Houston, TX 

5148 — B0152 Genetic Control of Rod Bipolar 

Cell Number and the Homotypic Regulation of 

Dendritic Field Size. Benjamin E. Reese, P. W. 

Keeley, I. E. Whitney, S. Borhanian. Neuroscience 

Research Institute, Univ of California-Santa 

Barbara, Santa Barbara, CA 

5149 — B0153 Retinal degenerative defects 

in the good effort mutant zebrafish are due to 

aberrant splicing of the chaf1b RNA. Travis J. 

Bailey, D. R. Hyde. Dept of Biological Sciences, 

University of Notre Dame, Notre Dame, IN 

5150 — B0154 TGF-β signaling protects 

retinal neurons from programmed cell death 

during development of the mammalian eye. 

Barbara M. Braunger 1 , S. M. Pielmeier 1 , C. 

Demmer 1 , V. I. Landstorfer 1 , D. Kawall 1 , I. Kleiter 3 , 

D. Fischer 4 , H. Jägle 2 , E. R. Tamm 1 . 1 Institute of 

Human Anatomy and Embryology, University of 

Regensburg, Regensburg, Germany; 2 Department 

of Ophthalmology, University Clinic, Regensburg, 

Germany; 3 St. Josef-Hospital, Ruhr-University 

Bochum, Bochum, Germany; 4 Experimental 

Neurology, Heinrich-Heine-University Düsseldorf, 

Düsseldorf, Germany 

5151 — B0155 The role of ADAM10 in retinal 

development. Joseph Toonen, D. J. Sidjanin. Cell 

Biology, Neurobiology, and Anatomy, The Medical 

College of Wiscosin, Milwaukee, WI 

5152 — B0156 ADAM10 mediates cleavage 

of N-cadherin ectodomain during retinal 

ganglion cell differentiation in primary cultured 

developing chick retinal cells. Jae-Chang 

Jung 1 , S. Paudel 1 , Y. Kim 1, 2 , S. Jung 1 , S. Kang 1 , 

S. Lee 1 , Y. Park 2 , K. Lee 2 . 1 Biology, Kyungpook 

national university, Daegu, Republic of Korea; 

2 

Ophthalmology, Cheil Eye Hospital, Daegu, 


5153 — B0157 Strain dependent expression 

of the alternative splicing factor, Sfrs10 

and its requirement in rod outer segment 

morphogenesis. Devi Krishna Priya Karunakaran, 

R. N. Kanadia. Physiology and Neurobiology, 

University of Connecticut, Storrs, CT 

5154 — B0158 Myocilin modulates 

programmed cell death during retinal 

development. Marcus A. Koch 1 , B. Rosenhammer 1 , 

S. E. Koschade 1 , B. M. Braunger 1 , C. Volz 2 , H. 

Jägle 2 , E. R. Tamm 1 . 1 Institute of Human Anatomy 

and Embryology, University of Regensburg, 

Regensburg, Germany; 2 University Clinical 

Center, Clinic and Policlinic for Ophthalmology, 

Regensburg, Germany 

5155 — B0159 Redundant Roles for Oc1 and 

Oc2 in Mouse Retinal Development. Darshan 

Sapkota 1, 2 , F. Wu 1, 2 , X. Mu 1, 2 . 1 Opthalmology 

and Biochemistry, University at Buffalo, Buffalo, 

NY; 2 SUNY Eye Institute, University at Buffalo, 

Buffalo, NY 

5156 — B0160 Cc2d2a is required for cilia 

axoneme development. Shobi Veleri 1 , S. H. 

Manjunath 1 , R. Sood 4 , P. Liu 4 , R. Fariss 3 , T. Li 1 , 

R. A. Rachel 1 , L. Dong 2 , A. Swaroop 1 . 1 Neurobiol- 

Neurodegen & Repair Lab, NEI/NIH, Bethesda, 

MD; 2 Genetic Engineering Core, NEI/NIH, 

Bethesda, MD; 3 Biological Imaging Core, NEI/NIH, 

Bethesda, MD; 4 Genetics and Molecular Biology, 

NHGRI/NIH, Bethesda, MD 

5157 — B0161 Nuclear dynamics in retinal 

development and homeostasis. Didier M. 

Hodzic, D. Razafsky. Ophthalmology, Washington 

University School of Medicine, St Louis, MO 


2:45 pm – 4:30 pm 


329



2:45 pm – 4:30 pm 

5158 — B0162 Molecular identity and 

specification of crossed versus uncrossed 

retinal ganglion cells. Qing Wang 1 , T. Kuwajima 2 , 

I. Cerullo 2 , C. A. Mason 1, 2 . 1 Neuroscience, 

Ophthalmology, Columbia University, New 

York, NY; 2 Pathology & Cell Biology, Columbia 


5159 — B0163 Aberrant axon development 

and up-regulation of c-Jun is associated with 

eye opening in Down’s syndrome cell adhesion 

molecule mutant. Dee Schramm 1 , P. G. Fuerst 1, 2 . 

1 

University of Idaho, Moscow, ID; 2 WWAMI 

Medical Education program, Univeristy of Idaho, 

Moscow, ID 

5160 — B0164 Angiotensin II selectively 

activates retinal microglia in mice. Joanna A. 

Phipps, N. Nag, K. A. Vessey, A. I. Jobling, E. 

L. Fletcher. Anatomy and Neuroscience, The 

Univeristy of Melbourne, Parkville, VIC, Australia 

*CR 

5161 — B0165 Expression of α-Internexin in 

Developing Chicken Retina. Chi-Hsiu Liu, F. Wei, 

C. Chien. Anatomy and Cell Biology, Department 

of Anatomy and Cell Biology, College of Medicine, 

National Taiwan University, Taipei, Taiwan 

5162 — B0166 Primary Culture and 

Characterization of Mouse Laminar Cells. Yan 

Guo 1 , Z. Mehrabyan 1 , C. J. Charniga 2 , S. Temple 2 , 

S. L. Bernstein 1 . 1 Ophthalmology, University of 

Maryland Baltimore, Baltimore, MD; 2 New York 

Stem Cell Institute, Albany, NY *CR 

5163 — B0167 Nerve growth factor-mediated 

vascular endothelial growth factor expression of 

astrocyte in retinal vascular development. Jeong 

Hun Kim 1 , Y. Kim 1 , H. Lee 2 , S. Kim 2 , N. Jeon 2 , J. 

Kim 1 . 1 Ophthalmology-Coll of Med, Seoul National 

Univ Hospital, Seoul, Republic of Korea; 2 School 

of Mechanical and Aerospace Engineering, Seoul 

National University, Seoul, Republic of Korea 

5164 — B0168 Perturbations of the developing 

albino mouse RPE during retinal ganglion cell 

genesis. Lena Iwai, A. Ramos, R. Blazeski, C. A. 

Mason. Pathology and Cell Biology, Columbia 


5165 — B0169 Foxk1 is expressed in the 

neuroretinal cells during development. Saadettin 

Sel 1 , C. Muenzenberg 3 , N. Nass 2 , M. Kaiser 3 , 

T. Kalinski 2 , F. E. Kruse 1 , F. P. Paulsen 4 , M. 

Schicht 4 . 1 Ophthalmology, University Erlangen- 

Nuremberg, Erlangen, Germany; 2 University 

Magdeburg, Magdeburg, Germany; 3 University 

Halle/Wittenberg, Halle/Saale, Germany; 4 Anatomy 

II, University Erlangen-Nuremberg, Erlangen, 

Germany 




472 Myopia II, AP 

Moderator: William K. Stell 

5166 — B0321 Megalin and myopia. Tina 

Storm 1 , S. Heegaard 2, 3 , E. I. Christensen 1 , R. 

Nielsen 1 . 1 Department of Biomedicine, Aarhus 

University, Aarhus, Denmark; 2 Eye Pathology 

Institute, Department of Neuroscience and 

Pharmacology, University of Copenhagen, 

Copenhagen, Denmark; 3 Department of 

Opthalmology, Glostrup Hospital, University of 

Copenhagen, Copenhagen, Denmark 

5167 — B0322 Refractive Development and 

Form-Deprivation in Dopamine D4 Receptor 

Knock-Out Mice. Han na Park 1 , C. C. Tan 1 , J. G. 

Light 1 , F. Aseem 1 , P. M. Iuvone 1, 2 , M. T. Pardue 1, 3 . 

1 

Ophthalmology, Emory University, Atlanta, GA; 

2 

Pharmacology, Emory University, Atlanta, GA; 

3 

Rehabilitation Research & Development Center, 

Atlanta Veterans Affairs Medical Center, Decatur, 

GA 

5168 — B0323 The effect of 2% homatropine 

on the choroidal thickness of young healthy 

adults. Beata P. Sander, M. J. Collins, S. A. Read. 

School of Optometry and Vision Science, QUT, 

Kelvin Grove, QLD, Australia 

5169 — B0324 In Vivo Crosslinking of Scleral 

Collagen in the Rabbit Using Sub-Tenon 

Injection of Nitroalcohol. Quan V. Hoang 1, 2 , Q. 

Wen 1 , S. Chang 1 , S. L. Trokel 1 , R. H. Silverman 1 , D. 

C. Paik 1 . 1 Ophthalmology, Harkness Eye Institute, 

Columbia Univ, New York, NY; 2 Vitreous, Retina, 

Macula Consultants of New York, New York, NY 

*CR 

5170 — B0325 Cross-linking of rabbit sclera 

using riboflavin and UVA for the prevention of 

progressive myopia. Assaf Dotan 1 , I. Kremer 1 , A. 

Zigler 2 , D. Bourla 1 . 1 Ophthalmology, Rabin Medical 

Center, Petach Tikva, Israel; 2 Racah Institute of 

Physics, The Hebrew University, Jerusalem, Israel 

5171 — B0326 Vascular endothelial growth 

Factor A, C, D and Vascular Endothelial Growth 

Factor Receptor 1, 2, 3 mRNA Expression in 

the Chicken Retina, RPE and Choroid. Marita 

P. Feldkaemper, F. Schaeffel, L. Fuchs. Centre for 

Ophthalmology, Institute for Ophthalmic Research, 

Tuebingen, Germany 

5172 — B0327 Effects of dual-focus, multizone 

lenses on refractive development in macaques. 

Baskar Arumugam 1, 2 , L. Hung 1, 2 , J. Huang 1, 2 , E. 

L. Smith 1, 2 . 1 College of Optometry, University of 

Houston, Houston, TX; 2 Vision CRC, Sydney, 


5173 — B0328 Histo-pathological and 

functional degenerative changes of Bruch’s 

membrane in form-deprivation myopia in chicks. 

Tzyy-Chang Ho. Ophthalmology, National Taiwan 

Univ Hospital, Taipei, Taiwan 

5174 — B0329 Effect of bright light on 

choroidal thickness in chickens as measured 

with OCT. Weizhong Lan 1, 2 , M. P. Feldkaemper 1 , 

F. Schaeffel 1 . 1 Section of Neurobiology of the 

Eye, Ophthalmic Research Institute, University 

of Tuebingen, Tuebingen, Germany; 2 Zhongshan 

Ophthalmic Center, Sun Yat-sen University, 

Guangzhou, China 

5175 — B0330 The efficacy of brief periods of 

“vision” in chick eyes wearing negative lenses is 

dependent on time of day. Debora L. Nickla, K. 

Totonelly. Biosciences, New England College of 

Optometry, Boston, MA 

5176 — B0331 The effect of two-zone 

concentric bifocal lenses on refractive error 

and eye shape in guinea pigs. Hannah E. 

Bowrey 1 , G. Zeng 1 , A. J. Leotta 1 , C. F. Wildsoet 2 , 

S. A. McFadden 1 . 1 The University of Newcastle, 

Callaghan, NSW, Australia; 2 The University of 

California, Berkeley, Berkeley, CA 

5177 — B0332 Comparing Rates of 

Emmetropization and Diurnal Rhythms Before 

and After Goggle Removal in Chick. Melanie 

C. Campbell 1, 2 , K. Bunghardt 1 , M. L. Kisilak 1, 2 , 

E. L. Irving 2 . 1 Physics & Astronomy, University 

of Waterloo, Waterloo, ON, Canada; 2 School of 

Optometry and Vision Science, University of 

Waterloo, Waterloo, ON, Canada *CR 

5178 — B0333 Temporal Frequency Sensitivity 

of the Emmetropization Mechanism in Chicks 

to Color and Luminance Flicker without Blue 

Light. Stephanie Britton, M. Fellows, F. J. Rucker. 

Biomedical Science, New England College of 

Optometry, Boston, MA 

5179 — B0334 The effect of induced 

myopia on the scleral creep response of whole 

chick eyes. Jacob A. Lewis 1 , M. Garcia 2 , C. F. 

Wildsoet 2 . 1 Bioengineering & Materials Science 

and Engineering, UC Berkeley, Berkeley, CA; 

2 

Vision Science, University of California Berkeley, 

Berkeley, CA 

5180 — B0335 Inhibition in peripheral scleral 

lengthening during the development of myopia 

in the guinea pig. Guang Zeng, S. A. McFadden. 

School of Psychology, the University of Newcastle, 

Callaghan, NSW, Australia 

5181 — B0336 Luminance variations can 

reduce or reverse plus lens compensation in 

chicks. Alan G. Busby. Biology, City College of 

New York, New York, NY 

5182 — B0337 Effects of a human anti- 

VEGF antibody (Bevacizumab) on myopia 

development and choroidal thickness in the 

chicken. Frank Schaeffel 1 , U. Mathis 1 , F. Ziemssen. 

1 

Section Neurobiology of Eye, Ophthalmic 

Research Institute, Tuebingen, Germany; 2 Center 

of Ophthalmology, University of Tuebingen, 



330


5183 — B0338 Anti-Diuretic Hormone 

Arginine-Vasopressin Promotes an Increased 

Myopic Shift in Refractive Compensation to 

Optical Defocus in Physiologically Stressful 

Environmental Light Conditions. Melanie 

J. Murphy 1 , S. G. Crewther 1 , S. N. Kiely 1 , N. 

Riddell 1 , L. Giummarra 1 , D. P. Crewther 2 . 1 School 

of Psychological Science, La Trobe University, 

Melbourne, VIC, Australia; 2 Centre for Human 

Psychopharmacology, Swinburne University of 

Technology, Melbourne, VIC, Australia 

5184 — B0339 The expression of vaoactive 

intestinal peptide receptors and ZENK protein 

in form-deprivation myopia. Hikmet Basmak 1 , 

H. Gursoy 1 , A. Cakmak 1 , N. Yildirim 1 , N. Tuncel 2 , 

N. Erkasap 2 , M. Ozkurt 2 . 1 Dept of Ophthalmology, 

Eskisehir Osmangazi Univ Med Sch, Eskisehir, 

Turkey; 2 Physiology, Eskisehir Osmangazi Univ 

Med Sch, Eskisehir, Turkey *CR 

5185 — B0340 Effects of Adenosine A2A 

Receptor on the Development of Form- 

Deprivation Myopia in Mice. Jianhong An 1 , 

X. Zhou 1 , F. Shi 1 , J. Chen 1, 2 , J. Qu 1 . 1 School of 

Ophthalmology & Optometry, Wenzhou Medical 

College, Wenzhou, Zhejiang, China; 2 Department of 

Neurology, Boston University School of Medicine, 

Boston, MA 

5190 — C0005 A Phase I/II Dose-Ranging, 

Randomized Clinical Trial of Abatacept 

(Orencia) in the Treatment of Refractory 

Non-Infectious Uveitis: Preliminary Results. 

Eric B. Suhler 1, 2 , T. R. Giles 2 , S. A. Hanel 2 , T. L. 

Liesegang 2 , R. M. Beardsley 2 , K. L. Larkin 2 , P. Lin 2 , 

J. T. Rosenbaum 2, 3 . 1 Ophthalmology, Portland VA 

Medical Center, Portland, OR; 2 Ophthalmology, 

Casey Eye Institute-OHSU, Portland, OR; 

3 

Ophthalmology, Devers Eye Institute, Portland, OR 

*CR, f 

5191 — C0006 Effectiveness of anti-Tumor 

Necrosis Factor agents in Pediatric Population 

with Uveitis. Rula Hajj-ali 1 , M. M. Choudhary 2 , 

A. Zeft 4 , S. Spalding 4 , S. K. Srivastava 3 , C. Y. 

Lowder 3 . 1 Orthopedics and Rheumatologic Institute, 

Cleveland Clinic Foundation, Cleveland, OH; 

2 

Internal Medicine, Cleveland Clinic Foundation, 

Cleveland, OH; 3 Ophthalmology, Cleveland 

Clinic Foundation, Cleveland, OH; 4 Pediatric 

Rheumatology, Cleveland Clinic Foundation, 

Cleveland, OH *CR 

5196 — C0011 Risk Factors Associated with 

Intraocular Pressure Rise in Patients with 

Uveitis Treated with the Fluocinolone Acetonide 

Implant. Anjali Parekh 1 , S. K. Srivastava 2 , 

T. A. Albini 3 , Q. Nguyen 4 , D. A. Goldstein 1 . 

1 

Ophthalmology, Northwestern Medical Faculty 

Foundation, Chicago, IL; 2 Ophthalmology, Cole 

Eye Institute, Cleveland, OH; 3 Ophthalmology, 

Bascom Palmer Eye Institute, Miami, FL; 

4 

Ophthalmology, Wilmer Eye Institute, Baltimore, 

MD *CR, f 

5197 — C0012 Fluocinolone Acetonide 

Implants for Refractory Uveitis: a Retrospective 

Review. Harpal S. Sandhu, P. Pillai, G. N. 

Papaliodis. Ophthalmology, Massachusetts Eye and 

Ear Infirmary, Boston, MA 

5198 — C0013 Combination chemotherapy 

with Mycophenolate mofetil and Cyclosporin 

in recalcitrant uveitis. Reena A. Rasheed 1, 2 , G. 

T. Markov 1, 3 , C. Foster 1 . 1 Ocular Immunology, 

Massachussett’s Eye Research and Surgery 

Institution, Massachussetts, MA; 2 Regional Institute 

of Ophthalmology, Trivandrum, India; 3 University 

Eye Hospital, Pashev, Bulgaria *CR 




473 Non-infectious Inflammation 

Moderator: Kazuichi Maruyama 

5186 — C0001 Etiology of Non-infectious 

Uveitis Following Cataract Surgery. Zvi A. 

Kresch 1 , C. Yang 3 , V. Diaz 1 , S. Kedhar 1 , J. V. 

Mauro 2 , C. Samson 1 . 1 Ophthalmology, NY Eye and 

Ear, New York, NY; 2 North Shore Eye Care, New 

York, NY; 3 High School, Newark, NJ *CR 

5187 — C0002 Trends in Patterns of 

Intermediate Uveitis in a Tertiary Institution in 

Singapore. Helen Mi 1 , S. Ho 2 , W. Lim 2 , E. Wong 2 , 

S. C. Teoh 2 . 1 Yong Loo Lin School of Medicine, 

National University of Singapore, Singapore, 

Singapore; 2 Ophthalmology, National Healthcare 

Group Eye Institute, Tan Tock Seng Hospital, 

Singapore, Singapore 

5188 — C0003 Epidemiology of Infectious 

Uveitis in Alabama. Christopher J. Compton, 

C. Huisingh, G. McGwin, R. W. Read, K. Beck. 

Ophthalmology, Univ of AL - Birmingham, 

Birmimgham, AL 

5189 — C0004 Characteristics of HLA-B27/ 

Ankylosing Spondylitis Associated Uveitis in 

Different Ethnicities. Russell W. Read 1, 2 , K. 

Beck 1 . 1 Ophthalmology, University of Alabama 

at Birmingham, Birmingham, AL; 2 Pathology, 

University of Alabama at Birmingham, 


5192 — C0007 Multicenter study of TNF-a 

antagonists for refractory Behçet’s uveitis in 

Spain. Marina Mesquida 1 , D. Diaz-Valle 2 , M. 

Cordero Coma 3 , A. Fonollosa 4 , V. Llorens 1 , L. 

Pelegrin 1 , M. Hernandez 5 , G. Espinosa 6 , B. Molins 1 , 

A. Adan Civera 1 . 1 Ophthalmology, Hospital Clinic 

de Barcelona, Barcelona, Spain; 2 Ophthalmology, 

Hospital Clinico San Carlos, Madrid, Spain; 

3 

Ophthalmology, Hospital de León, León, Spain; 

4 

Ophthalmology, Hospital Universitario Cruces, 

Bilbao, Spain; 5 Rheumatology, Hospital Clínic 

de Barcelona, Barcelona, Spain; 6 Autoimmune 

Disease, Hospital Clínic de Barcelona, Barcelona, 

Spain *CR 

5193 — C0008 Pharmacological blockade 

of interleukin 6 receptor (IL-6R) inhibits the 

development of ocular inflammation in the 

murine model of experimental autoimmune 

uveitis (EAU). Jingtai Cao, T. C. MacPherson, G. 

D. Yancopoulos, S. J. Wiegand. Ophthalmology, 

Regeneron Pharmaceuticals Inc, Tarrytown, NY 

*CR 

5194 — C0009 Treatment of Chronic, 

Persistent, Non-infectious, Non-granulomatous 

Uveitis in Patients with Juvenile Idiopathic 

Arthritis. Anton M. Kolomeyer 1 , Y. Tu 1 , N. V. 

Nayak 1 , E. Miserocchi 2 , D. S. Chu 1, 3 . 1 Institute of 

Ophthalmology and Visual Science, University 

of Medicine and Dentistry of NJ, Newark, NJ; 

2 

Department of Ophthalmology and Visual 

Sciences, Scientific Institute San Raffaele, 

University Vita-Salute, Milan, Italy; 3 Metropolitan 

Eye Research and Surgery Institute, Palisades Park, 

NJ *CR 

5195 — C0010 Characteristics of patients who 

attain remission of inflammatory eye disease 

following treatment and discontinuation of 

mycophenolate mofetil. Travis Jenkins, T. Truong, 

K. Lai, Z. A. Kresch, V. Diaz, J. V. Mauro, S. 

Kedhar, C. Samson. Ophthalmology, The New York 

Eye and Ear Infirmary, New York, NY *CR 

5199 — C0014 Macular thickness 

measurements with spectral domain optical 

coherence tomography during active episode of 

Unilateral Acute Anterior Uveitis. David Diaz- 

Valle, S. Garcia-Vidal, P. Arriola-Villalobos, R. 

Cuina, J. A. Gegundez-Fernandez, J. M. Benitezdel-Castillo. 

Ophthalmology, Hospital Clinico San 

Carlos, Madrid, Spain 

5200 — C0015 Evolution of intra ocular 

inflammation in treated acute anterior uveitis. 

Margaux Guillard 1 , E. Perrin 2 , B. Kirwan 2 , D. 

Monnet 1 , A. P. Brezin 1 . 1 Ophthalmology, Cochin 

Hospital - University Paris Descartes, Paris, France; 

2 

Socar Research SA, Nyon, Switzerland 

5201 — C0016 Use of Immunosuppressive 

Medications for Treatment of Pediatric 

Intermediate Uveitis. Spencer R. Cope 1 , A. O. 

Hersh 1 , A. Shakoor 2 , J. F. Bohnsack 1 , A. T. Vitale 2 . 

1 

Division of Pediatrics Rheumatology, University 

of Utah, Salt Lake City, UT; 2 Ophthalmology and 

Visual Sciences, John A. Moran Eye Center, Salt 

Lake City, UT *CR 

5202 — C0017 Genetic analysis of risk alleles 

associated with inflammatory bowel disease 

in acute anterior uveitis. Tammy M. Martin, P. 

Stauffer, E. Patridge, C. Younkins, M. Burcham, J. 

R. Smith. Ophthalmology, Oregon Health & Science 

Univ, Portland, OR 

5203 — C0018 Optic nerve spectral domain 

optical coherence tomography of papillitis 

secondary to uveitis. Parvathy Pillai, L. Sobrin. 



5204 — C0019 Correlation between Disease 

Activity and Choroidal Patterns by OCT-EDI in 

Birdshot Chorioretinopathy. Andrea D. Birnbaum, 

A. A. Fawzi, L. M. Rifkin, D. A. Goldstein. 

Ophthalmology, Northwestern Univ Feinberg Sch 

of Med, Chicago, IL *CR 


2:45 pm – 4:30 pm 


331

5205– 5228 – Wednesday – Posters 


2:45 pm – 4:30 pm 

5205 — C0020 Segmentation and Analysis 

of Retinal Layers in Eyes with Uveitis and 

Comparison with Normal. Syed Mahmood A. 

Shah, Y. J. Sepah, M. A. Sadiq, S. Kherani, M. 

A. Ibrahim, Z. S. Rentiya, M. Ansari, D. V. Do, 

Q. Nguyen. Wilmer Eye Institute, Johns Hopkins 


5206 — C0021 Predictive Value of Angiotensin 

Converting Enzyme, Soluble Interleukin-2 

Receptor and Lysozyme for Pulmonary 

Involvement in Human Ocular Sarcoidosis. 

Rafael Grajewski 1 , W. Adler 2 , K. Frank 3 , M. 

Arfaoui 1 , S. L. Schlereth 1 , B. Kirchhof 1 , C. 

Cursiefen 1 , L. M. Heindl 1 . 1 Ophthalmology, 

University of Cologne, Cologne, Germany; 

2 

Medical Informatics, Biometry and Epidemiology, 

Friedrich-Alexander University Erlangen-Nürnberg, 

Erlangen, Germany; 3 Internal Medicine III, 

University of Cologne, Cologne, Germany *CR 




474 Corneal Infection/Inflammation I 

Moderator: Robert M. Shanks 

5207 — C0126 MyD88-dependent and 

-independent antimicrobial activity in mouse 

corneas induced by Pseudomonas aeruginosa 

antigen challenge. Suzanne M. Fleiszig, D. J. 

Evans, C. Tam. School of Optometry, Univ of 

California - Berkeley, Berkeley, CA *CR 

5208 — C0127 An Experimental Model 

of Biofilm Formation in the Mouse Cornea. 

Padmanabhan Saraswathi, T. T. Aung, S. Salleh, R. 

W. Beuerman. Singapore Eye Research Institute, 


5209 — C0128 The role of autophagy in 

Pseudomonas aeruginosa keratitis. Xiaoyu Jiang, 

S. A. McClellan, R. P. Barrett, Y. Zhang, M. E. 

Foldenauer, K. Vistisen, L. D. Hazlett. Department 

of Anatomy and Cell Biology, Wayne State 

University School of Medicine, Detroit, MI 

5210 — C0129 Toll-like receptor 4: A regulator 

of apoptosis in the infected cornea. Sharon A. 

McClellan, X. Jiang, Y. Zhang, K. Vistisen, R. P. 

Barrett, L. D. Hazlett. Anatomy & Cell Biology, 

Wayne State Univ School of Med, Detroit, MI 

5211 — C0130 Galectin-1-Mediated 

Suppression of Th17 Cell-Induced Corneal 

Immunopathology post Pseudomonas aeruginosa 

Infection. Amol Suryawanshi 1 , Z. Cao 1 , T. S. Zaidi 2 , 

N. A. Panjwani 1 . 1 New England Eye Center and 

Department of Ophthalmology, Tufts University 

School of Medicine, Boston, MA; 2 Department of 

Medicine, Brigham and Women’s Hospital, Boston, 

MA 

5212 — C0131 In Vivo Efficacy of Keratin- 

Derived Antimicrobial Peptides (KDAMPs) 

in Corneal Defense Against Pseudomonas 

aeruginosa. Connie Tam. School of Optometry, 

Univ of California, Berkeley, Berkeley, CA *CR 

5213 — C0132 Proteomic Analysis of the 

Keratitis Associated Pseudomonas aeruginosa. 

Abby L. Sewell, J. J. Dunmire, M. Wehmann, R. 

Bouhenni. Ophthalmology Research, Summa Health 

System, Akron, OH 

5214 — C0133 Pseudomonas aeruginosa uses 

type three secretion-dependent and -independent 

mechanisms for traversal of multilayered corneal 

epithelia. Aaron B. Sullivan 1 , V. Hritonenko 1 , C. 

Tam 1 , D. J. Evans 2 , S. M. Fleiszig 1 . 1 School of 

Optometry, UC Berkeley, Berkeley, CA; 2 College 

of Pharmacy, Turo University- California, Vellejo, 

CA *CR 

5215 — C0134 ExoS, a type III secreted toxin, 

is produced intracellularly by P. aeruginosa after 

corneal epithelial cell invasion, and is triggered 

by exposure to cell lysates. Victoria Hritonenko 1 , 

A. L. Jolly 1 , C. Maloney 2 , A. Farfel 3 , D. J. Evans 1, 4 , 

S. M. Fleiszig 1 . 1 School of Optometry, University of 

California, Berkeley, CA; 2 Dept. of Environmental 

Science, Policy, and Management, University of 

California, Berkeley, AR; 3 Dept. of Molecular & 

Cell Biology, University of California, Berkeley, 

CA; 4 College of Pharmacy, Touro University 

California, Vallejo, CA *CR 

5216 — C0135 VIP Treatment of Bacterial 

Keratitis Against Multiple Pseudomonas Strains. 

Elizabeth A. Berger, L. D. Hazlett. Anatomy & Cell 

Biology, Wayne State Univ Sch of Med, Detroit, MI 

5217 — C0136 IL-1R and TLR-5 mediate 

corneal epithelial defense against Pseudomonas 

aeruginosa colonization and traversal 

respectively. David J. Evans 1, 2 , C. Tam 2 , S. M. 

Fleiszig 2 . 1 College of Pharmacy, Touro University 

California, Vallejo, CA; 2 School of Optometry, UC 


5218 — C0137 Microbiological and electron 

microscopic assessment of Pseudomonas 

aeruginosa infection of primary human corneal 

fibroblasts and epithelial cells in-vitro. Ahmad 

Elsahn 1, 2 , P. Hossain 2, 1 , M. Christodoulides 1 . 

1 

Molecular Microbiology, University of 

Southampton, Southampton, United Kingdom; 

2 

Southampton Eye Unit, University Hospitals 

Southampton NHS Foundation Trust, Southampton, 


5219 — C0138 Cystic Fibrosis Transmembrane 

conductance Regulator (CFTR) competes with 

Pseudomonas aeruginosa Type 3 Secretion 

System (T3SS) to direct the fate of intracellular 

bacteria. Amber L. Jolly 1 , S. A. Whiteside 1 , D. J. 

Evans 2, 1 , S. M. Fleiszig 1 . 1 Vision Sciences, UC 

Berkeley, Berkeley, CA; 2 College of Pharmacy, 

Touro University, Vallejo, CA *CR 

5220 — C0139 Impediment of corneal cell 

migration by a Serratia marcescens factor in an 

in vitro wound healing model. Kimberly Brothers, 

N. A. Stella, J. Klarlund, R. M. Shanks. University 

of Pittsburgh, Pittsburgh, PA *CR 

5221 — C0140 Isolation of Two Proteases 

from Streptococcus pneumoniae that Cause 

Corneal Erosions. Mary E. Marquart, S. D. 

Taylor. Microbiology, Univ of Mississippi Med Ctr, 

Jackson, MS 

5222 — C0141 Genomics of the Conjunctival 

Pathogen Streptococcus pneumoniae. Michael 

Valentino 1 , W. Haas 2 , C. M. Sanfilippo 2 , J. W. 

Rosch 3 , E. I. Tuomanen 3 , T. W. Morris 2 , M. S. 

Gilmore 1 . 1 Harvard Medical School / Mass. Eye 

& Ear Infirmary, Boston, MA; 2 Bausch & Lomb, 

Inc., Rochester, NY; 3 St. Jude Children’s Research 

Hospital, Memphis, TN *CR 



Cornea / Biochemistry/Molecular Biology 

475 Corneal Wound Repair, 

Transparency II 

Moderator: Shizuya Saika 

5223 — C0142 MicroRNA signature in wound 

healing following excimer laser ablation: 

Role of miR-133b on TGF- β, CTGF, collagen 

and smooth muscle actin synthesis in corneal 

fibroblast. Paulette M. Robinson 1, 2 , T. Chuang 1 , S. 

Sriram 1 , L. Pi 1 , X. Luo 1 , B. Petersen 2 , G. S. Schultz 1 . 

1 

OB-GYN, University of Florida, Gainesville, FL; 

2 

Pediatrics, University of Florida, Gainesville, FL 

5224 — C0143 Long-term visual outcomes 

in the Steroids for Corneal Ulcers Trial. Scott 

M. McClintic 1 , S. M. McClintic 1 , N. V. Prajna 2 , 

M. Srinivasan 2 , J. Mascarenhas 2 , L. Prajna 2 , 

T. Porco 1, 3 , N. Acharya 1, 3 , T. M. Lietman 1, 3 , J. 

D. Keenan 1, 3 . 1 Ophthalmology, University of 

California, San Francisco, San Francisco, CA; 

2 

Cornea and External Diseases, Aravind Eye Care 

System, Madurai, India, Madurai, India; 3 Francis I. 

Proctor Foundation, University of California, San 

Francisco, San Francisco, CA *CR 

5225 — C0144 The Effect of Local Rock- 

Inhibition on Corneal Scarring After Alkali 

Burn Injury. Davine Sijnave 1 , K. P. Hollanders 1 , 

T. Van Bergen 1 , S. Van de Velde 1 , E. Vandewalle 1 , 

L. K. Moons 2 , D. Leysen 3 , I. Stalmans 1 . 1 Lab of 

Ophthalmology, KULeuven, Leuven, Belgium; 

2 

Department of Biology, KULeuven, Leuven, 

Belgium; 3 Amakem Therapeutics, Diepenbeek, 

Belgium *CR 

5226 — C0145 Abnormal epithelial basement 

membrane ultrastructure in corneas with haze 

after PRK in rabbits. Andre A. Torricelli 1, 2 , V. 

Singh 1 , V. Agrawal 1 , S. E. Wilson 1 . 1 Ophthalmology, 

Cleveland Clinic, Cleveland, OH; 2 Ophthalmology, 

FMUSP, Sao Paulo, Brazil *CR 

5227 — C0146 Substance P potentiates 

Anti-Fas induced apoptosis in human corneal 

fibroblasts. Peter Boman 1, 2 , S. Le Roux 1 , P. 

Danielson 1, 2 . 1 Anatomy, Umeå University, Umeå, 

Sweden; 2 Dept. of Clinical Science, Ophthalmology, 

Umeå Univeristy, Umeå, Sweden 

5228 — C0147 TGF-β1 modulates the 

functional expression of the NK-1 receptor in 

human corneal fibroblasts. Sandrine LE ROUX, P. 

Boman, P. Danielson. Anatomy, Dept. of Integrative 

Medical Biology, Anatomy, Umeå University, 

Umeå, Sweden 


332


5229 — C0148 A Long-Lasting Scar in Murine 

Cornea. Andrew Hertsenberg, S. Basu, Y. Du, J. 

L. Funderburgh. Ophthalmology, University of 

Pittsburgh School of Medicine, Pittsburgh, PA 

5230 — C0149 Autologous Platelet Rich 

Plasma Therapy in Resistant Corneal Ulcers. 

Yakup Aksoy 1 , U. Erdem 2 . 1 Ophthalmology, Gülhane 

Military Medical Academy Haydarpasa Education 

Hospital, istanbul, Turkey; 2 Ophthalmology, 

Gülhane Military Medical Faculty, Ankara, Turkey 

5231 — C0150 Initial Evidence that Immune 

Cell Infiltrates are Candidate Sources of Post- 

Surface Ablation Stromal Roughening. Daniel J. 

Gibson, G. S. Schultz. Obstetrics and Gynecology, 

University of Florida, Gainesville, FL 

5232 — C0151 Outcomes of Traumatic 

Dehiscence of Penetrating Keratoplasty versus 

Severe Open-Globe Injury. Therese Peron, 

M. A. Woodward, R. M. Shtein. Department of 


Arbor, MI 

5233 — C0152 Proteomic analysis of the 

interaction Fusarium solani - Staphylococcus 

epidermidis isolated from human corneal 

ulcers. Mariana Ortiz-Casas 1 , A. V. Rodríguez- 

Tovar 2 , J. Reyes-Grajeda 3 , H. Mejia-Lopez 1 , M. 

A. Martínez-Rivera 2 , L. A. Bautista-Hernández 1 , 

C. Gaona-Juárez 1 , N. López-Espinosa 1 , V. M. 

Bautista 1 . 1 Microbiology and Proteomics, Institute 

of Opthalmology “Conde de Valenciana”, Mexico 

City, Mexico; 2 Medical Mycology, Escuela 

Nacional de Ciencias Biológicas, IPN, Mexico 

City, Mexico; 3 Medical Proteomics Unit, Instituto 

Nacional de Medicina Genómica, Mexico City, 

Mexico 

5234 — C0153 Collagen vitrigels for cornea 

reconstruction: collagen source and crosslinking. 

Shoumyo Majumdar 1, 2 , M. Garza-Madrid 2, 3 , X. 

Calderon-Colon 4 , M. Trexler 4 , O. D. Schein 5 , 

J. Elisseeff 1, 2 . 1 Biomedical Engineering, Johns 

Hopkins University, Baltimore, MD; 2 Translational 

Tissue Engineering Center, Wilmer Eye Institute, 

Johns Hopkins School of Medicine, Baltimore, 

MD; 3 Ophthalmology and Visual Sciences 

Research Chair, School of Medicine and Health 

Sciences, Tecnológico de Monterrey, Monterrey, 

Mexico; 4 Applied Physics Laboratory, Johns 

Hopkins University, Laurel, MD; 5 Department 

of Ophthalmology, Wilmer Eye Institute, Johns 

Hopkins School of Medicine, Baltimore, MD *CR 

5235 — C0154 A Role for Macrophage-derived 

Interleukin-20 in Mouse Corneal Epithelial 

Wound Healing. Wanyu Zhang 1 , C. W. Smith 2 , 

Z. Li 2 , A. R. Burns 1, 2 . 1 College of Optometry, 

University of Houston, Houston, TX; 2 Pediatricsleukocyte 

biology, Baylor College of Medicine, 

Houston, TX 

5236 — C0155 The Effects of Amniotic 

Membrane Extract on Primary Human Corneal 

Epithelial Cells. David V. Dudok 1 , K. Cheung 1 , 

H. Liu 1 , L. Vedovelli 3 , E. Ghinelli 2 , K. Kenyon 2 , 

S. Parapuram 1 , C. M. Hutnik 1 . 1 Ophthalmology, 

Western University Canada, London, ON, Canada; 

2 

Ophthalmology, Massachusetts Eye & Ear 

Infirmary, Boston, MA; 3 Division of Nephrology, 

Cell Biology, Human Biology and Physiology, 

Massachusetts General Hospital, Boston, MA 

5237 — C0156 Sex-Specific Differences in the 

Corneal Inflammatory Reparative Response via 

Estrogen Modulation of Phagocytosis. Samantha 

B. Wang, K. M. Hu, Y. Wang, D. W. Lin, J. Jong, 

J. Lai, K. Gronert. Vision Science Program, 

University of California, Berkeley, Oakland, CA 



Cornea 

476 Corneal Stroma and Keratocytes 

Moderator: Holly B. Hindman 

5238 — C0157 Keratocyte-Keratocyte 

Translamellar Connectivity in the Mouse Cornea 

is Revealed using a Novel 3-D Ultrastructural 

Approach. Samuel D. Hanlon 1 , N. C. Shenoi 1 , 

P. T. Harris 1 , P. T. Landry 1 , A. R. Behzad 2 , E. S. 

Brown 1 , M. M. Gondo 1 , A. R. Burns 1, 3 . 1 Research, 

Univ of Houston College of Optometry, Houston, 

TX; 2 Imaging and Characterization Core Lab, King 

Abdullah University of Science and Technology, 

Thuwal, Saudi Arabia; 3 Leukocyte Biology, Baylor 

College of Medicine, Houston, TX 

5239 — C0158 Effect of Serum Clot Activator 

on Keratocytes. Ji-Eun Lee 1 , S. Lee 2 , J. Lee 1 . 

1 

Ophthalmology, Pusan National University, 

Pusan, Republic of Korea; 2 Ophthalmology, Kosin 

University, Pusan, Republic of Korea 

5240 — C0159 Co-cultures of Human Corneal 

Epithelium and Self-assembled Keratocyte 

and Fibroblast Matrix. Audrey E. Hutcheon 1, 2 , 

D. Karamichos 1, 2 , X. Q. Guo 1, 2 , J. D. Zieske 1, 2 . 

1 

Schepens Eye Research Institute/MEE, Boston, 

MA; 2 Department of Ophthalmology, Harvard 


5241 — C0160 RNAi Gene Silencing Of TGFbeta 

Signaling: A Powerful Approach To Control 

Corneal Fibrosis. Jason T. Rodier, A. Sharma, 

A. Tandon, A. Stallard, R. R. Mohan. Mason 

Eye Institute, University of Missouri-Columbia, 

Columbia, MO 

5242 — C0161 Up-Regulation of Apoptotic 

Markers Following β-Actin Gene-Silencing 

in Corneal Stromal Fibroblasts. Roy Joseph 1 , 

O. P. Srivastava 1 , R. R. Pfister 2 . 1 Department of 

Vision Sciences, Univ of Alabama at Birmingham, 

Birmingham, AL; 2 Eye Research Foundation, 


5243 — C0162 Collective Spreading and 

Migration of Corneal Fibroblasts in Fibrin 

Matrices are not Dependent on Increased Cell 

Contractility. Miguel Miron Mendoza, M. Petroll. 

Ophthalmology, Univ of Texas Southwestern Med 

Ctr, Dallas, TX 


333 

5244 — C0163 Alarmin from corneal epithelial 

cells synergizes with Th2 cytokines on the 

expression of CCL11 and VCAM-1 by corneal 

fibroblasts. Ken Fukuda 1 , H. Tanaka 2 , W. Ishida 1 , 

Y. Harada 1 , T. Sumi 1 , A. Matsuda 3 , N. Ebihara 3 , 

A. Fukushima 1 . 1 Ophthalmology, Kochi Medical 

School, Nankoku, Japan; 2 Ophthalmology, Machida 

Hospital, Kochi, Japan; 3 Ophthalmology, Juntendo 

University School of Medicine, Tokyo, Japan *CR 

5245 — C0164 Mitomycin C Suppresses 

Gene Splicing in Corneal Fibroblasts. Tsan-Chi 

Chen 1 , S. Chang 1, 2 , C. Lee 1 , H. Teng 1 . 1 Department 

of Ophthalmology, Far Eastern Memorial 

Hospital, New Taipei City, Taiwan; 2 Department 

of Ophthalmology, National Taiwan University 

Hospital, Taipei, Taiwan f 

5246 — C0165 The anti-fibrotic Halofuginone 

regulates the expression of Egr-1 in human 

corneal fibroblasts. Ching Yuan, M. Twite, E. F. 

Nelson. Ophthalmology and Visual Neurosciences, 

University of Minnesota, Minneapolis, MN 

5247 — C0166 Effect of TGF-β1 and 3 on 

protein expression in human corneal fibroblasts. 

Xiaoqing Q. Guo 1, 2 , A. E. Hutcheon 1, 2 , J. D. 

Zieske 1, 2 . 1 Schepens Eye Research Institute/MEE, 

Boston, MA; 2 Department of Ophthalmology, 

Harvard Medical School, Boston, MA 

5248 — C0167 Thrombin regulates Cyr61 

synthesis and processing in cultured human 

corneal stromal fibroblasts and myofibroblasts. 

Emily A. Andreae 1 , D. J. Warejcka 1 , S. S. Twining 2 . 

1 

Biochemistry, The Medical College of Wisconsin, 

Milwaukee, WI; 2 Biochemistry and Ophthalmology, 

The Medical College of Wisconsin, Milwaukee, WI 

5249 — C0168 Trichostatin A inihibits TGFβ-induced 

reactive oxygen species accumulation 

and myofibroblast differentiation via enhanced 

Nrf2-ARE signaling. Qingjun Zhou, L. Yang, M. 

Qu. Shandong Eye Institute, Qingdao, China 

5250 — C0169 Exploring cell plasticity: the 

corneal keratocyte and beyond. Carol A. Greene, 

T. Sherwin, C. R. Green. Ophthalmology, University 

of Auckland, Auckland, New Zealand 

5251 — C0170 Reprogramming Genes Are 

Expressed during Spheroidal Culture of Corneal 

Stromal Cells. Yong-Soo Byun, L. Yco, B. Shaheen, 

A. Sharma, S. Chaudhary, S. Gandhi, S. H. Jassim, 

J. Sarkar, S. Tibrewal, S. Jain. Ophthalmology and 

Visual Sciences, University of Illinois at Chicago, 

Chicago, IL *CR 


2:45 pm – 4:30 pm



2:45 pm – 4:30 pm 

5252 — C0171 Tissue-engineered corneal 

stromal substitutes transplanted in the living 

feline model: biocompatibility, ultrastructure 

and performance. Marie Boulze Pankert 1, 2 , B. 

Goyer 3 , M. Bareille 2 , K. Singh 2 , S. Proulx 3, 5 , I. 

Brunette 2, 4 . 1 Departement d’ophtalmologie, Centre 

Hospitalier Universitaire de l’Université de la 

Mediterranée, Marseille, France; 2 Maisonneuve- 

Rosemont Hospital Research Center, Montreal, QC, 

Canada; 3 Centre LOEX de l’Université Laval, Génie 

tissulaire et régénération - Centre de recherche 

FRQS du Centre Hospitalier Universitaire, Quebec, 

QC, Canada; 4 Department of Ophthalmology, 

University of Montreal, Montreal, QC, Canada; 

5 

Département d’ophtalmologie et d’oto-rhinolaryngologie, 

Faculté de médecine, Université 

Laval, Quebec, QC, Canada 

5253 — C0172 Reinnervation of corneal 

stroma reconstructed by tissue engineering 

transplanted in the living feline model. Fatma 

Zaguia 1 , M. Boulze Pankert 2, 1 , B. Goyer 3 , S. 

Proulx 3, 5 , I. Brunette 1, 4 . 1 Hopital Maisonneuve 

Rosemont, Montreal, QC, Canada; 2 Université 

de la Mediterranée, Marseille, France; 3 Centre 

de recherche FRSQ de Centre hospitalier affilié 

universitaire du quebec- Universite Laval, Quebec, 

QC, Canada; 4 Université de Montréal, Montreal, 

QC, Canada; 5 Université Laval, Montreal, QC, 

Canada 

5254 — C0173 A stromal corneal nerves 

analysis in type 2 diabetic patients by confocal 

microscopy. Manuel Ramirez, E. Hernandez- 

Quintela. Cornea, APEC, Mexico City, Mexico 

5255 — C0174 Interclass Synergistic Effects of 

Small Leucine-Rich Proteoglycans in Regulating 

Collagen Fibrillogenesis During Corneal 

Development. Shoujun Chen 1 , S. Chakravarti 2 , D. 

E. Birk 1 . 1 Department of Molecular Pharmacology 

and Physiology, University of South Florida, 

Tampa, FL; 2 Department of Medicine, Johns 

Hopkins University, Baltimore, MD 

5256 — C0175 Collagen XII regulates 

collagen fibril packing, lamellar organization, 

stromal architecture and corneal function. 

Chinda Hemmavanh 1 , E. M. Espana 1, 2 , D. E. 

Birk 1 . 1 Molecular Pharmacology and Physiology, 

USF Morsani College of Medicine, Tampa, FL; 

2 

Ophthalmology, University of South Florida, 

Tampa, FL 

5257 — C0176 Extracellular matrix 

characterization of the acellular gammairradiated 

cornea. Jemin J. Chae 1 , J. S. Choi 1 , 

W. Stark 2 , J. Elisseeff 1 . 1 Biomedical Engineering, 

Johns Hopkins University, Baltimore, MD; 

2 

Ophthalmology, Johns Hopkins University, 


5258 — C0177 Structural changes in the 

anterior corneal stroma of bullous keratopathy 

patients after endothelial keratoplasty. Naoyuki 

Morishige, Y. Morita, N. Yamada, K. Sonoda. Dept 

of Ophthalmology, Yamaguchi Univ Grad Sch of 

Med, Ube, Japan 



Cornea 

477 Corneal Cross-linking and 

Keratoconus 

Moderator: Shameema Sikder 

5259 — C0178 MDV1224 A New Riboflavin 

Formulation for Trans-Epithelial Cross-Linking. 

Sergio Mangiafico, D. Aleo. R&D, Medivis, 

Catania, Italy *CR 

5260 — C0179 Corneal sensitivity changes 

following cross-linking for progressive lower 

stage keratoconus. Belquiz A. Nassaralla 1 , A. M. 

Lago 1 , L. S. Stival 1 , J. J. Nassaralla 2 . 1 Cataract 

Cornea & Refractive Surgery, Instituto de Olhos 

de Goiania, Goiania, Brazil; 2 Retina and Vitreous, 

Instituto de Olhos de Goiania, Goiania, Brazil f 

5261 — C0180 Impact of corneal cross-linking 

on drug penetration in humans. Christoph 

Tappeiner, M. Tschopp, K. Schuerch, B. E. Frueh. 

Department of Ophthalmology, Inselspital, 

University Hospital of Bern, Bern, Switzerland 

5262 — C0181 Apparent progression in 

children after corneal cross-linking for 

keratoconus. Beatrice E. Frueh, C. Tappeiner. 

Ophthalmology, Univ of Bern Inselspital, Bern, 

Switzerland 

5263 — C0182 Corneal Endothelial Cell 

Density Following Transepithelial Collagen 

Cross-Linking. Michael W. Raciti 1 , R. J. Epstein 1, 2 , 

P. Majmudar 1, 2 , W. Trattler 3 . 1 Rush University 

Medical Center, Chicago, IL; 2 Chicago Cornea 

Consultants, Chicago, IL; 3 Center For Excellence In 

Eye Care, Miami, FL *CR 

5264 — C0183 Concurrent vs Sequential 

Corneal Collagen Crosslinking and Intacs ® 

for Keratoconus and Corneal Ectasia. Steven 

A. Greenstein 1, 2 , P. S. Hersh 2, 1 . 1 Ophthalmology, 

UMDNJ - New Jersey Medical School, Newark, 

NJ; 2 Cornea and Laser Eye Institute - Hersh Vision 

Group, Teaneck, NJ *CR, f 

5265 — C0184 A new constant-force technique 

to measure corneal biomechanical changes after 

corneal collagen cross-linking. David Tabibian 1 , 

O. Richoz 1 , E. Spoerl 3 , A. Hammer 1 , F. Hoogewoud 1 , 

F. Hafezi 1, 2 . 1 Ophthalmology, Geneva University 

Hospital, Geneva, Switzerland; 2 Ophthalmology, 

Doheny Eye institute, Keck School of Medicine 

USC, Los Angeles, CA; 3 Ophthalmology, 

University Hospital Dresden, Dresden, Germany 

*CR 

5266 — C0185 Corneal collagen crosslinking 

in young patients: One-year results. Marcony 

R. Santhiago 2, 1 , M. L. Monteiro 1 , H. Moraes 1 , 

R. Espindola 1 , R. C. Ghanem 1 , M. Netto 1 . 

1 

Ophthalmology, Federal University of Rio de 

Janeiro, Rio de Janeiro, Brazil; 2 Cataract and 

Refractive Surgery - Ophthalmology, Federal 

University of Rio de Janeiro, Rio de Janeiro, Brazil 


334 

5267 — C0186 Two-year results of corneal 

cross-linking in pediatric patients with 

progressive keratoconus. Dan Epstein 1 , B. E. 

Frueh 2 , E. Albé 3 , P. Vinciguerra 3 . 1 Ophthalmology, 

Research Institute, Bern, Switzerland; 

2 

Ophthalmology, University of Bern, Inselspital, 

Bern, Switzerland; 3 Ophthalmology, Istituto clinico 

Humanitas, Milan, Italy *CR 

5268 — C0187 Fluorescein Competes 

Riboflavin in CXL (Corneal Collagen Cross- 

Linking) for the Treatment of Infectious 

Keratitis. Farhad Hafezi 1, 2 , Z. Gatzioufas 1 , 

A. Hammer 1 , D. Tabibian 1 , O. Richoz 1 . 

1 

Ophthalmology, Geneva University Hospitals, 

Geneva, Switzerland; 2 Ophthalmology, Doheny 

Eye Institute, Keck School of Medicine USC, Los 


5269 — C0188 In Vivo Ultrasound-enhanced 

Penetration Of Topical Riboflavin Into The 

Corneal Stroma. Ricardo Lamy, E. Chan, H. 

Zhang, V. Salgaonkar, C. J. Diederich, J. M. 

Stewart. Ophthalmology, University of California, 

San Francisco, San Francisco, CA 

5270 — C0189 Combining Iontophoresis and 

corneal collagen crosslinking: a basic science 

study on human corneas. Rita Mencucci, I. 

Paladini, E. Favuzza, U. Menchini, M. Marini, E. 

Sarchielli, B. Vannelli. Ophthalmology, Eye Clinic 

University of Florence, Firenze, Italy 

5271 — C0190 Accelerated cross-linking in 

patients with keratoconus: 6 months follow-up. 

Johnny Javier Castellar Cerpa, J. Peraza Nieves, R. 

Cuiña Sardiña, D. Diaz-Valle, R. Mendez, J. García 

Bella, J. Fernández-Vigo, J. M. Benitez-del-Castillo. 

Ophthalmology, Hospital Clinco San Carlos, 

Madrid, Spain 

5272 — C0191 Corneal Deformation 

Characteristics and IOP before and after 

Collagen Crosslinking. Cynthia J. Roberts, A. 

M. Mahmoud, R. G. Lembach, T. F. Mauger. 

Department of Ophthalmology and Department of 

Biomedical Engineering, The Ohio State University, 

Columbus, OH *CR, f 

5273 — C0192 Results of cross-linking in 

keratoconic corneas on visual function. One 

year follow-up. Ricardo Cuina, J. Vazquez- 

Molini, D. Diaz-Valle, J. M. Benitez-del-Castillo. 

Oftalmología, Hospital Clínico San Carlos, Madrid, 

Spain 

5274 — C0193 Impact of Riboflavin 

Formulations on Corneal Hydration. Evan A. 

Sherr, P. Kamaev, S. Rood-Ojalvo, M. D. Friedman, 

D. Muller. Avedro, Inc, Waltham, MA *CR 

5275 — C0194 Assessment the long term effect 

of corneal cross-linking therapy on corneal 

ectasia in progressive keratoconus. Illes Kovacs, 

K. Kranitz, A. Gyenes, G. L. Sándor, E. Juhasz, 

L. Dienes, J. Nemeth, Z. Z. Nagy. Department of 

Ophthalmology, Semmelweis University, Budapest, 

Hungary *CR 

5276 — C0195 Use of Zonal Km vs Point Kmax 

for Analysis of Corneal Cross-linking Pentacam 

Topography. Grace Lytle 1 , M. D. Friedman 1 , P. S. 

Hersh 2 , D. Muller 1 . 1 Avedro Inc, Waltham, MA; 

2 

Hersh Vision Group, Cornea and LASER EYE 

Institute, Teaneck, NJ *CR


5277 — C0196 Evaluation of corneal flattening 

in progressive keratoconus with Scheimpflug 

imaging. Kinga Kranitz, I. Kovacs, A. Gyenes, G. 

L. Sándor, E. Juhasz, L. Dienes, J. Nemeth, Z. Z. 

Nagy. Department of Ophthalmology, Semmelweis 

University, Budapest, Hungary *CR 

5278 — C0197 Corneal Collagen Crosslinking 

in Keratoconic Eyes at Different Stages. Nurullah 

Cagil, O. Sarac, E. Akcay, N. Ugurlu, E. Can, 

G. Can. Department of Ophthalmology, Yildirim 

Beyazit University, Ankara, Turkey 

5279 — C0198 Shorter UVA Light Exposure 

Protocol for Crosslinking in Keratoconus in 

Children Without Progression Criteria. Andres 

Codriansky 1, 2 , M. Aravena 1, 2 , M. Coria 1, 2 . 1 Cornea 

and Refractive Surgery, Hospital Sotero del Rio / 

IOPA, Santiago, Chile; 2 Cataract Surgery, Hospital 

Sotero del Rio, Santiago, Chile 

5280 — C0199 Papain Digestion Method for 

Analysis of Cross-linking in Corneal Flaps. Sara 

Rood-Ojalvo, P. Kamaev, M. D. Friedman, D. 

Muller. Avedro Inc., Waltham, MA *CR 

5281 — C0200 Accelerated UVA-RF Corneal 

Cross-linking through Pulsed UVA Illumination 

and Oxygen Rich Environments. David Muller, 

P. Kamaev, M. D. Friedman, E. A. Sherr, W. A. 

Eddington. Avedro, Waltham, MA *CR 

5282 — C0201 Topical alternatives to 

therapeutic riboflavin photochemical tissue 

cross-linking: a comparison of cell toxicity 

thresholds. Mi Jung Kim, Q. Wen, Q. V. Hoang, S. 

L. Trokel, D. C. Paik. Ophthalmology, Columbia 

University, College of Physicains and Surgeons, 

New York, NY *CR, f 

5283 — C0202 Corneal Thickness Changes 

during Collagen Crosslinking using Riboflavin/ 

Dextran or Hypotonic Riboflavin. Elan A. 

Rosenblat 1, 2 , A. L. Sachs 2 , S. A. Greenstein 1, 2 , P. S. 

Hersh 2, 1 . 1 Department of Ophthalmology, Inst of 

Ophthalmology and Visual Science, Newark, NJ; 

2 

Cornea and Laser Eye Inst- Hersh Vision Group, 

Teaneck, NJ *CR, f 

5284 — C0203 Aliphatic β-nitroalcohols for 

therapeutic corneoscleral tissue cross-linking: 

catalytic studies. David C. Paik, Q. Wen, M. 

Kim, Q. V. Hoang, S. L. Trokel. Ophthalmology, 

Columbia University, New York, NY *CR 

5285 — C0204 Analysis of Thickness of 

Corneas from Eye Banks After Application 

Of Isosmolar Riboflavin And Hiposmolar 

Riboflavin. Luiz Felipe L. Moraes 2, 1 , L. Barbosa 2 , 

M. Macedo 2 , T. Rayes 2 . 1 Ophthalmology, Federal 

University of Pernambuco, Recife, Brazil; 

2 

Ophthalmology, Sorocaba Eye Bank, Sorocaba, 

Brazil 

5286 — C0205 Crosslinking Corneal Collagen 

using Rose Bengal and Green Light. Irene E. 

Kochevar 1 , T. Gisel 1 , E. E. Verter 1 , G. Scarcelli 1 , S. 

H. Yun 1 , R. H. Webb 1 , R. W. Redmond 1 , S. Melki 2 . 

1 

Wellman Center for Photomedicine, Massachusetts 

General Hospital, Boston, MA; 2 Boston Eye Group, 


5287 — C0206 Collagen Crosslinking By 

Infrared Femtosecond Pulses In Ex-vivo 

Corneas. Juan M. Bueno, H. S. Ginis, R. Palacios, 

A. Pennos, P. Artal. Laboratorio de Optica, 

Universidad de Murcia, Murcia, Spain *CR 

5288 — C0207 Accelerated corneal crosslinking 

with pulsed light. Pavel Kamaev, W. A. 

Eddington, S. Rood-Ojalvo, M. D. Friedman, D. 

Muller. Research, Avedro, Waltham, MA *CR 

5289 — C0208 Long term follow-up of 

stiffening of rabbit corneas by WST11 using near 

infrared light. Arie L. Marcovich 1, 2 , A. Brandis 1 , I. 

Feine 3 , I. Pinkas 1 , R. Goldschmidt 1 , V. Kalchenko 4 , 

D. H. Wagner 5 , Y. Salomon 3 , A. Scherz 1 . 1 Plant 

Sciences, Weizmann Institute of Science, Rehovot, 

Israel; 2 Ophthalmology, Kaplan Medical Center, 

Rehovot, Israel; 3 Biological Regulation, Weizmann 

Institute of Science, Rehovot, Israel; 4 Veterinary 

Resources, Weizmann Institute of Science, Rehovot, 

Israel; 5 Materials and Interfaces, Weizmann Institue 

of Science, Los Angeles, CA *CR 

5290 — C0209 Antimicrobial efficacy of 

riboflavin / UV-A collagen cross-linking at 

different fluences in vitro. Florence Hoogewoud, 

O. Richoz, F. Hafezi. Ophtalmology, University 

Hospital of Geneva, Geneva, Switzerland *CR 

5291 — C0210 Combination of Intracorneal 

ring segments (Ferrara and Intacts) in the care 

of patients with Keratoconus. Roberto Albertazzi 1 , 

L. Ferlini 1 , L. D. Perrone 1 , D. M. Perrone 1 , G. 

Rao 1 , J. F. Alfonso 2, 3 , J. Merayo-Lloves 2, 3 . 1 Centro 

de Ojos Quilmes, Quilmes, Argentina; 2 Fundación 

de Investigacion Oftalmologica - Instituto 

Oftalmológico Fernández-Vega, oviedo, Spain; 

3 

University of Oviedo, oviedo, Spain *CR 

5292 — C0211 Hydrogen-Loaded Eye Drops 

Suppress Progression of Keratoconus-Like 

Corneal Lesion of SKC Mouse. Naoko Kato 1, 2 , 

Y. Uchino 2 , E. Inagaki 2 , S. Ohta 3 , K. Tsubota 2 . 

1 

Ophthalmology, National Defense Medical 

College, Saitama, Japan; 2 Ophthalmology, Keio 

University School of Medicine, Tokyo, Japan; 

3 

Biochemistry and Cell Biology, Institute of 

Development and Aging Sciences, Graduate School 

of Medicine, Nippon Medical School, Kanagawa, 

Japan *CR 

5293 — C0212 Presence of lysyl oxidase-like 

enzymes in human control and keratoconic 

corneas. Lubica Dudakova, S. Kalasova, K. 

Jirsova. Laboratory of the Biology and Pathology 

of the Eye, Charles University, Prague, Czech 

Republic 

5294 — C0213 Anterior-segment OCT 

epithelial mapping in early and advanced 

keratoconic eyes. Feilin Zhu 1 , A. Kanellopoulos 1, 2 , 

G. Asimellis 2 . 1 Ophthalmology, NYU Medical 

Center, New York, NY; 2 Laservision Eye Institute, 

Athens, Greece *CR 


335 

5295 — C0214 Low-frequency dielectric 

spectroscopy of normal and keratoconus human 

cornea. Dorota Tarnawska 1, 3 , A. Kocot 1 , M. 

Jastrzebska 2 , E. Wylegala 3 , A. Ratuszna 2 . 1 Dept. 

of Biophysics and Molecular Physics, Institute of 

Physics, University of Silesia, Katowice, Poland; 

2 

Department of Solid State Physics, Institute of 

Physics, University of Silesia, Katowice, Poland; 

3 

Department of Ophthalmology, Railway Hospital, 

Katowice, Poland 

5296 — C0215 Correlation between 

keratoconus progression and two cornea 

topometric parameters: the regularity of the 

pachymetric map (RPM) and the Index of height 

decentration (IHD). George Asimellis, I. Kontari, 

A. Kanellopoulos. Research, LaserVision.gr Eye 

Institute, Athens, Greece *CR 

5297 — C0216 Comparison of threedimensional 

optical coherence tomography 

parameters for early keratoconus diagnosis. 

Shinichi Fukuda 1 , S. Hoshi 1 , M. Yamanari 2, 3 , S. 

Beheregaray 1 , T. Hiraoka 1 , Y. Yasuno 2 , T. Oshika 1 . 

1 

Ophthalmology, Tsukuba University, Tsukuba, 

Japan; 2 Computational Optics Group, Tsukuba 

University, Tsukuba, Japan; 3 Tomey Corporation, 

Nagoya, Japan *CR 

5298 — C0217 Decreased corneal sensitivity 

to chemical and thermal stimuli in keratoconus 

patients. Lorant Dienes 1 , K. Kranitz 1 , Z. Z. Nagy 1 , 

J. Nemeth 1 , M. Acosta 2 , J. Gallar 2 , C. Belmonte 2 , I. 

Kovacs 1 . 1 Ophthalmology, Semmelweis University, 

Budapest, Hungary; 2 Instituto de Neurociencias, 

Univ Miguel Hernandez-CSIC, Alicante, Spain *CR 

5299 — C0218 Remodeling Processes in 

Keratoconic Epithelium. Jesus Merayo-Lloves 1 , 

A. Íñigo-Portugués 1 , E. Artime 1 , F. J. Colina 1 , F. 

Bech 1 , J. F. Alfonso 2, 1 , L. M. Quirós 3 , A. Astudillo 4 , 

M. Fernández 2, 1 , I. Alcalde 1 . 1 Ocular Surface, 

Fundación de Investigación Oftalmológica, Oviedo, 

Spain; 2 Ocular Surface, Instituto Oftalmológico 

Fernández-Vega, Oviedo, Spain; 3 Functional 

Biology, Universidad de Oviedo, Oviedo, Spain; 

4 

Pathology, Hospital Central de Asturias, Oviedo, 

Spain *CR 

5300 — C0219 Phenotype of Keratoconus 

Patients at King Khaled Eye Specialist Hospital. 

Samar A. Al-Swailem, S. C. Yiu, A. Al-Assiri, N. 

Asghar, A. Al-Qassimi. Anterior Segment, King 

Khaled Eye Specialist Hosp, Riyadh, Saudi Arabia 

5301 — C0220 Increased expression of 

secreted frizzled-related protein-1 (SFRP-1) and 

microtubule-associated protein light chain 3 

(LC3) in keratoconus. Omer Iqbal, G. Fisher, S. 

Vira, D. Kahn, D. Syed, J. Fareed, C. S. Bouchard. 

Ophthalmology, Loyola, Maywood, IL 

5302 — C0221 IL1B promoter polymorphisms 

are associated with keratoconus in a Japanese 

population. Takenori Mikami 1, 2 , A. Meguro 1 , T. 

Teshigawara 2 , M. Takeuchi 1 , M. Ishioka 1, 3 , M. 

Iwasaki 3 , K. Fukagawa 3 , K. Konomi 4 , J. Shimazaki 4 , 

N. Mizuki 1 . 1 Ophthalmology and Visual Science, 

Yokohama City University Graduate School of 

Medicine, Yokohama, Japan; 2 Yokosuka Chuoh 

Eye Clinic, Yokosuka, Japan; 3 Ryogoku Eye Clinic, 

Tokyo, Japan; 4 Department of Ophthalmology, 

Ichikawa General Hospital, Tokyo Dental College, 

Ichikawa, Japan *CR 


2:45 pm – 4:30 pm



2:45 pm – 4:30 pm 

5303 — C0222 Keratoconus Gene Mapping: 

Candidate Genes in the 14q11.2 homozygous 

region. Govindasamy Kumaramanickavel 1 , V. 

Anandula 1 , V. Ramprasad 3 , N. Jeyabalan 1 , A. 

Ghosh 1 , R. Shetty 2 . 1 Basic Science Research, 

Narayana Nethralaya, Bangalore, India; 2 Cornea, 

Narayana Nethralaya, Bangalore, India; 3 Spinco- 

Biotech, Chennai, India 

5304 — C0223 Homozygosity Mapping of 

Keratoconus to 12p13.1 region: The Ideal 

Candidate Genes. Venkata Ramana Anandula 1 , 

V. Anandula 1 , V. Ramprasad 2 , N. Jeyabalan 1 , R. 

Shetty 1 , A. Ghosh 1 , G. Kumaramanickavel 1 . 1 Basic 

Science Research, Narayana Nethralaya, Bangalore, 

India; 2 Advanced Genomics, Spinco Biotech, 

Chennai, India 

5305 — C0224 Use of the polygenic model to 

predict risk of keratoconus using GWAS data. 

Xiaohui Li 1, 2 , Y. Bykhovskaya 2, 3 , T. Haritunians 1 , 

D. Siscovick 4 , A. J. Aldave 5 , L. B. Szczotka- 

Flynn 6 , S. K. Iyengar 7 , J. I. Rotter 1 , K. Taylor 1 , Y. 

S. Rabinowitz 3 . 1 Medical Genetics, Cedars-Sinai 

Medical Center, Los Angeles, CA; 2 Cornea Genetic 

Eye Institute, Cedars-Sinai Medical Center, Los 

Angeles, CA; 3 Regenerative Medicine Institute, 

Cedars-Sinai Medical Center, Los Angeles, CA; 

4 

Cardiovascular Health Research Unit, University 

of Washington, Seattle, WA; 5 The Jules Stein Eye 

Institute, University of California Los Angeles, Los 

Angeles, CA; 6 Ophthalmology & Visual Sciences, 

Case Western Reserve University, Cleveland, 

OH; 7 Epidemiology & Biostatistics, Case Western 

Reserve University, Cleveland, OH *CR 




478 Vision Function and Quality of Life 

Moderators: Pradeep Y. Ramulu and 

Beatriz E. Munoz 

5306 — D0067 What are people rating when 

they rate their vision status? Associations with 

Vision Tests and Self-Reported Visual Function 

in the Salisbury Eye Evaluation Study. Mahmood 

El-Gasim 1 , B. E. Munoz 2 , S. K. West 2 , A. W. Scott 3 . 

1 

School of Medicine, Johns Hopkins University, 

Baltimore, MD; 2 Dana Center for Preventive 

Ophthalmology, Johns Hopkins University, 

Baltimore, MD; 3 Wilmer Eye Institute, Johns 

Hopkins University, Baltimore, MD 

5307 — D0068 Controlling Photophobia and 

Light-Induced Headache: the Use of Artificial 

Pupil Contact Lenses. Mary M. Jackowski 1, 2 , 

B. Motter 1, 3 . 1 VA Medical Center, Syracuse, 

NY; 2 Ophthalmology, SUNY Upstate Medical 

University, Syracuse, NY; 3 Neuroscience and 

Physiology, SUNY Upstate Medical University, 

Syracuse, NY 

5308 — D0069 Quantifying the Impact of 

Vision Training using Short Duration Transient 

Visual Evoked Potential (SD-tVEP). Robert 

Orsillo 1 , P. H. Derr 2 . 1 Orsillo Vision Care, 

Tallahasse, FL; 2 Diopsys Inc, Pine Brook, NJ *CR 

5309 — D0070 Quality of life of Keratoconus 

Patients in an Asian Population. Hon Kiat 

Wong, J. Lim, W. Heng. Ophthalmology, National 

Healthcare Group Eye Institute, Tan Tock Seng 

Hospital, Singapore, Singapore 

5310 — D0071 Dry eye and Changes in Driving 

Habits: The Salisbury Eye Evaluation. Jamie 

Brown 1 , E. K. Akpek 1 , S. W. van Landingham 1 , S. 

K. West 1, 2 , B. E. Munoz 1, 2 , P. Y. Ramulu 1, 2 . 1 Johns 

Hopkins Wilmer Eye Institute, Baltimore, MD; 

2 

Dana Center for Preventive Ophthalmology, 


5311 — D0072 Comparing Better-eye and 

Integrated Visual Field Mean Deviation as 

Metrics for Capturing Visual Disability. Karun 

S. Arora, M. V. Boland, D. S. Friedman, J. L. 

Jefferys, S. K. West, P. Y. Ramulu. Ophthalmology, 

Johns Hopkins University School of Medicine, 

BALTIMORE, MD *CR 

5312 — D0073 Comparing the Impact of 

Refractive and Non-Refractive Vision Loss on 

Disability. Nazlee Zebardast, S. K. West, B. E. 

Munoz, P. Y. Ramulu. Johns Hopkins Wilmer Eye 

Institute, Baltimore, MD 

5313 — D0074 Rasch analysis of the glaucomaspecific 

module of the Eye-tem Bank project. 

Konrad Pesudovs 1 , J. Khadka 1 , E. K. Fenwick 2 , 

E. L. Lamoureux 2, 3 . 1 NHMRC Ctr Clin Eye Res/ 

Optometry, Flinders University SA, Adelaide, SA, 

Australia; 2 Centre for Eye Research Australia, 


Australia; 3 Singapore Eye Research Institute, 


Singapore 

5314 — D0075 Cognitive dysfunction reduces 

vision-specific quality of life in older Asian 

adults. Peggy P. Chiang 1, 3 , C. Sabanayagam 1, 

3 

, Y. Zheng 5 , T. Y. Wong 1, 4 , E. L. Lamoureux 2, 

1 

. 1 Epidemiol, Hlth Services Rsrch, Singapore 

Eye Research Inst, Singapore, Singapore; 

2 

Ophthalmology, Centre for Eye Research Australia, 


Australia; 3 Duke-NUS Graduate Medical School, 

Singapore, Singapore; 4 Ophthalmology, Department 

of Ophthalmology, National University of 

Singapore, Singapore, Singapore; 5 Ophthalmology, 

Zhongshan Ophthalmic Center, Sun Yat-Sen 

University, Guangzhou, China *CR 

5315 — D0076 Assessment of Disability 

Weights Associated with Visual Acuity 

Impairment in Patients from a University 

Hospital in Brazil. Solange R. Salomao 1 , N. N. 

Cavascan 1 , A. Berezovsky 1 , M. R. Mitsuhiro 1 , 

P. Y. Sacai 1 , A. Araujo-Filho 1 , P. A. Morales 1 , 

S. E. Watanabe 1 , R. Belfort 1 , L. B. Ellwein 2 . 

1 

Departamento de Oftalmologia, Universidade 

Federal de Sao Paulo, Sao Paulo, Brazil; 2 NEI, 

Bethesda, MD *CR 

5316 — D0077 New Method for the 

Classification of Vitreous Floaters and Study 

of their Correlations with Ocular Biometry. 

Irene Ruiz 1, 2 , J. J. Rozema 1, 2 , M. B. Tassignon 1, 2 . 

1 

Ophthalmology, Antwerp University Hospital, 

Edegem, Belgium; 2 Medicine and Health Science, 

University of Antwerp, Wilrijk, Belgium 


336 

5317 — D0078 Participants’ experiences in a 

clinical trial for vision restoration: Motivation 

to participate, visual perception and functional 

use, and experience of loss following termination. 

Frank J. Lane 1 , P. R. Troyk 2 , K. P. Nitsch 1 . 

1 

Pyschology, Illinois Insitute of Technology, 

Chicago, IL; 2 Biomedical Engineering, Illinois 

Insitute of Technology, Chicago, IL *CR 

5318 — D0079 Developing a questionnaire to 

measure the quality of life of Blepharitis patients. 

Linda Bourque 1, 2 , M. M. Kelley 1, 2 , K. Hosseini 2 . 

1 

Fielding School of Public Hlth, University of 

California, Los Angeles, Los Angeles, CA; 2 InSite 

Vision, Inc., Alameda, CA *CR, f 

5319 — D0080 Evaluation of Methods 

Handling Missing Diary Data for Statistical 

Analysis in Dry Eye Studies. Hui-Chun T. Hsu, D. 

W. Usner, R. Abelson. Biostatistics, Statistics and 

Data Corporation, Tempe, AZ *CR 

5320 — D0081 Visual Function Affects 

Reported Depressive Symptoms and Suicidal 

Ideation in Older Adults. Priyanka Jain 1 , M. 

Smith 2 , J. V. Odom 1 , G. Miller 1 , C. Moore 1 , M. 

J. Leys 1 . 1 WVU Eye Institute, Morgantown, 

WV; 2 Psychology, West Virginia University, 

Morgantown, WV 

5321 — D0082 Subjective Influences on Visual 

Acuity Testing Performance: A Prospective 

Study with Non-accommodating Intra-ocular 

Lenses. Arvind V. Iyer 1 , E. R. Chu 2 , B. X. Pan 2 , B. 

S. Tjan 3 , A. A. Sadun 2 , K. L. Lu 2 , F. E. Udwadia 4 . 

1 

Biomedical Engineering, University of Southern 

California, Los Angeles, CA; 2 Ophthalmology, 


CA; 3 Psychology, University of Southern California, 

Los Angeles, CA; 4 Aerospace and Mechanical 

Engineering, University of Southern California, Los 


5322 — D0083 Educational and vision-assistive 

smartphone Apps for patients: a quantitative 

evaluation. Stephanie Kletke 1 , S. Arora 2 , F. Adatia 3 . 

1 

Medicine, McMaster University, Hamilton, 

ON, Canada; 2 Ophthalmology, University of 

Alberta, Edmonton, AB, Canada; 3 Ophthalmology, 

University of Calgary, Calgary, AB, Canada 

5323 — D0084 Patient Experience During the 

Fitting Process for the Prosthetic Replacement of 

the Ocular Surface Ecosystem (PROSE) Device. 

Eda Dou, Y. Wang, R. M. St Clair, M. N. Lee, M. 

Rosenblatt, P. Sood, A. G. Alzaga Fernandez, C. 

E. Starr, J. Ciralsky, K. C. Sippel. Ophthalmology, 

Weill Cornell Medical College, New York, NY 

5324 — D0085 Importance of Physical Activity 

and Low Vision: Preliminary Findings from 

an Adaptive Sport and Recreation Program 

for Military Service Members with Low 

Vision. Laura E. Dreer 1, 2 , C. Block 1 , A. Wood 1 , S. 

Robinson 2 , M. Goff 2 , L. Malone 2 . 1 Ophthalmology/ 

Callahan Eye Fndtn Hosp, Univ of Alabama 

at Birmingham, Birmingham, AL; 2 Lakeshore 

Foundation, Birmingham, AL *CR


5325 — D0086 Fear of falling, activity 

restriction and self-reported physical function 

among older adults with glaucoma. Alex A. 

Black, J. M. Wood. School of Optometry and Vision 

Science, Queensland University of Technology, 

Brisbane, QLD, Australia 

5326 — D0087 Can chronic visual symptoms 

measures accurately predict acute visual 

discomfort symptoms? Stefanie A. Drew 1 , A. 

Escobar 2 , C. Liu 3 , E. Castellanos 3 , L. R. Stark 4 , 

E. Borsting 4 , C. Chase 3 . 1 Psychology, California 

State University, Northridge, Northridge, CA; 

2 

2U, Inc., Landover, MD; 3 College of Optometry, 

Western University of Health Sciences, Pomona, 

CA; 4 Southern California College of Optometry, 

Fullerton, CA f 

5327 — D0088 Contrast Sensitivity, 

Electroretinography and Optical Coherence 

Tomography Changes in Young Subjects After 

an Acute Unacclimatized Short Exposure to 

High Altitude. Mehmet S. Karakucuk, B. Polat, 

E. Mirza, H. Arda, K. Gumus, A. Oner. Dept. of 

Ophthalmology, Erciyes University Faculty of 

Medicine, Kayseri, Turkey 

5328 — D0089 Age-related eye disease and 

cognitive status. Solmaz Moghadaszadeh 1 , H. 

Boisjoly 1, 2 , M. Kergoat 3 , J. Rousseau 3 , F. Djafari 1, 2 , 

E. E. Freeman 1, 2 . 1 Ophtalmology, Maisonneuve- 

Rosemont’s Hospital, Montreal, QC, Canada; 

2 

Ophthalmology, Université de Montréal, Montreal, 

QC, Canada; 3 Centre de Recherche, Institut 

universitaire de gériatrie de Montréal, Montreal, 

QC, Canada 

5329 — D0090 DIGS and ADAGES: 

Relationship Between Rates of Binocular 

Visual Field Loss and Vision-Related Quality of 

Life in Glaucoma. Renato Lisboa 1, 2 , Y. Chun 1, 3 , 

L. M. Zangwill 1 , R. N. Weinreb 1 , P. Rosen 1 , J. 

M. Liebmann 4 , C. A. Girkin 5 , F. A. Medeiros 1 . 

1 

Ophthalmology, Hamilton Glaucoma Center, La 

Jolla, CA; 2 Ophthalmology, Federal University of 

São Paulo, São Paulo, Brazil; 3 Ophthalmology, 

Chung-Ang University, Seoul, Republic of Korea; 

4 

Opthtalmology, New York Eye and Ear Infirmary, 

Ney York, NY; 5 Ophthalmology, University of 

Alabama, Birmingham, AL *CR, f 

5330 — D0091 Utility and Uncorrected 

Refractive Error. Nina Tahhan 1, 2 , E. B. Papas 1, 3 , 

T. R. Fricke 1 , K. D. Frick 4 , B. A. Holden 1, 3 . 1 Brien 


2 

School of Optometry & Vision Science, UNSW, 

Sydney, NSW, Australia; 3 Vision Cooperative 

Research Centre, Sydney, NSW, Australia; 4 Johns 

Hopkins Bloomberg School of Public Health, 


5331 — D0092 An iPad Test of Letter Contrast 

Sensitivity. Mark A. Bullimore 1 , M. E. Jansen 2 , E. J. 

Kollbaum 2 , P. S. Kollbaum 2 . 1 College of Optometry, 

University of Houston, Boulder, CO; 2 School of 

Optometry, Indiana University, Bloomington, IN 

*CR 

5332 — D0093 Fear of falling in age-related 

macular degeneration. Sabyasachi Sengupta, S. 

W. van Landingham, R. W. Massof, E. Chan, D. 

S. Friedman, P. Y. Ramulu. Wilmer Eye Institute, 


5333 — D0094 Photophobia and Light- 

Induced Headache: Novel Long-Term 

Effects of Pilocarpine. Brad Motter 1, 3 , M. M. 

Jackowski 1, 2 . 1 VA Medical Center, Syracuse, 

NY; 2 Ophthalmology, SUNY Upstate Medical 

University, Syracuse, NY; 3 Neuroscience and 

Physiology, SUNY Upstate Medical University, 

Syracuse, NY 

5334 — D0095 Is visual impairment just 

another comorbid condition? Bonnielin K. 

Swenor, B. E. Munoz, S. K. West. Ophthalmology, 

Johns Hopkins Wilmer Eye Institute, Baltimore, 

MD 

5335 — D0096 Development of an Arabic 

version of the National Eye Institute Visual 

Function Questionnaire as a tool to study eye 

diseases patients in Egypt. Nizar F. Saleh 1, 2 , A. A. 

Salama 3 , M. A. Abdel-Baqy 4 , M. E. Israel 5 , G. A. 

Elhawary 5 , A. E. Radwan 3 , T. M. EL Nakhal 2 , I. T. 

Elkhateb 6 , A. M. Kassem 2 , M. Amgad 6 . 1 Cortoba Eye 

Femtolaser Centers, Cairo, Egypt; 2 Ophthalmology, 

Faculty of Medicine University of Alexandria, 

Alexandria, Egypt; 3 Ophthalmology, Faculty of 

Medicine - Menofeyya University, Shebin El-Kom, 

Egypt; 4 Alexandria Regional Center for Women’s 

Health & Development, Alexandria, Egypt; 5 Faculty 

of Medicine - Ain Shams University, Cairo, Egypt; 

6 

Faculty of Medicine - Cairo University, Cairo, 

Egypt 

5336 — D0097 The Impact of Visual Field Loss 

and Hearing Loss on Social Function. Bei Bei 

Chen, N. Zebardast, F. R. Lin, P. Y. Ramulu, D. S. 

Friedman. Johns Hopkins, Baltimore, MD *CR 

5337 — D0098 The Effect of Comprehensive 

Vision Rehabilitation on Self-Administration 

of Medication in Patients with Central Vision 

Loss. Catherine J. Choi, J. Wallis, M. Jackson. 


Infirmary, Boston, MA f 

5338 — D0099 Blue streetlights effect on visual 

acuity in glaucoma. Kozo Masuda 1 , H. Uozato 2 . 

1 

Health and Social Services, Osaka University of 

Human Sciences, Settsu, Japan; 2 Ophthalmology 

and Visual Science, Kitasato University, 

Sagamihara, Japan 

5339 — D0100 How Maryland Eye Care 

Practitioners Complete the Motor Vehicle 

Administration (MVA)Vision Screening 

Form. Ruidi Wang, R. Miller, H. D. Jampel. 

Ophthalmology, Johns Hopkins Wilmer Eye 

Institute, Baltimore, MD *CR 





479 Oculoplastics and Orbital Disease: 

Prognosis, Diagnosis and Outcomes 

Moderator: Timothy J. McCulley 

5340 — D0101 Periorbital and Ocular Injury 

from Industrial Hooks. Daniel G. Straka, S. 

Thinda, M. R. Melson, L. A. Mawn. Ophthalmology, 

Vanderbilt Eye Institute, Nashville, TN *CR 

5341 — D0102 Predictors and Outcomes of 

Orbital Floor Fractures requiring Surgical 

repair. Clarissa Cheng, L. Lee. Ophthalmology, 

National Healthcare Group Eye Institute, Tan Tock 

Seng Hospital, Singapore, Singapore 

5342 — D0103 Observation of the orbital floor 

with magnetic resonance imaging after surgery 

for orbital floor fractures. Hidetoshi Onda, T. 

Ueda, Y. Kamijo, M. Yoshida. Ophthalmology, 

Showa Univ Sch of Medicine, Tokyo, Japan 

5343 — D0104 Orbital and Preseptal Cellulitis: 

Our Experience at a Referral Center in 

Southeast Louisiana. Namita Bhardwaj 1, 2 , A. B. 

al-Hariri 1 . 1 Department of Ophthalmology, Ochsner 

Clinic Foundation, New Orleans, LA; 2 Department 

of Ophthalmology, Louisiana State University, New 

Orleans, LA 

5344 — D0105 Orbital Cerebrospinal Fluid 

Leak Following Pterional Orbitozygomatic 

Craniotomy. Zakeya M. Alsadah 1 , M. K. Yoon 3 , T. 

J. McCulley 2, 1 . 1 oculoplastics, kkesh, riyadh, Saudi 

Arabia; 2 oculoplastics, Wilmer Eye Institute, Johns 

Hopkins, baltimore, MD; 3 Massachusetts Eye and 

Ear Infirmary, boston, MA 

5345 — D0106 Cosmetic and quality of life 

outcomes of the direct brow lift. Srinivas Sai A. 

Kondapalli 1 , C. N. Czyz 2 , J. A. Foster 3 , K. V. Cahill 3 . 

1 

Ophthalmology, Loyola University Medical Center, 

Westchester, IL; 2 Ophthalmology, Ohio University, 

Doctor’s Hospital, Columbus, OH; 3 Ophthalmology, 

The Ohio State University, Columbus, OH 

5346 — D0107 The effect of eyelid 

manipulation on exophthalmometry values. 

Aubrey Gilbert, M. K. Yoon. Ophthalmology, 

Massachusetts Eye and Ear Infirmary, Boston, MA 

5347 — D0108 Age Related Gender Differences 

in the Occurrence of Acquired Nasolacrimal 

Duct Obstruction in Saudi Arabia. Laura Phan 1 , 

T. J. McCulley 1, 2 . 1 Ophthalmology, Wilmer Eye 

Institute, Baltimore, MD; 2 Ophthalmology, King 

Khaled Eye Specialist Hospital, Riyadh, Saudi 

Arabia 


2:45 pm – 4:30 pm 


337


5348 — D0109 Giant fornix syndrome with 

chronic methicillin resistant staphylococcus 

aureus conjunctivitis causing nasal lacrimal 

duct obstruction. Jackson F. Lever 1 , E. Eubanks 2 , 

C. K. Gupta 1 , A. Barmettler 1 , J. Servat 3 , F. 

Nesi-Eloff 1 . 1 Beaumont Eye Institute, William 

Beaumont Hospital, Royal Oak, MI; 2 School of 

Medicine, Wayne State University, Detroit, MI; 

3 

Ophthalmology, Yale School of Medicine, New 

Haven, CT 

5349 — D0110 Pott’s Puffy Tumor Arising 

From Pansinusitis - A Mimicker of Preseptal 

Cellulitis. Li Wei Heng, E. Poh. Ophthalmology, 

Tan Tock Seng Hospital, Singapore, Singapore 

5350 — D0111 Ki67 Proliferation Index 

as a Prognostic Factor in Ocular Adnexal 

Lymphoma. Matthew C. Sniegowski, B. Esmaeli. 

University of Texas MD Anderson Cancer Cencer, 

Houston, TX 

5351 — D0112 Histopathology after temporary 

tarsorrhaphy. Larissa K. Ghadiali 1 , K. C. Piotti 2 , 

G. J. Lelli 3 . 1 Ophthalmology, New York Medical 

College, Valhalla, NY; 2 Department of Pathology 

and Laboratory Medicine, New York Presbyterian 

Hospital-Weill Cornell Medical Center, New York, 

NY; 3 Ophthalmology, New York Presbyterian 

Hospital-Weill Cornell Medical Center, New York, 

NY 

5352 — D0113 Recognition of External Eye 

Photos: HIPAA Implications. Maya H. Maloney, 

E. Bradley. Ophthalmology, Mayo Clinic, 

Rochester, MN 


2:45 pm – 4:30 pm 


338

Wednesday – Lectures – 5353 – 5354 

6E 


481A Cogan Award and Lecture 

The Cogan Award recognizes a young researcher 

who is 40 years of age or less at the time of 

nomination. This person will have made important 

and worthwhile contributions to research in 

ophthalmology or visual science which directly 

relates to disorders of the human eye or visual 

system, and will have shown substantial promise for 

the future. 

— 5:30 Introduction. Peter Sterling. Library, 

University of Pennsylvania, Philadelphia, PA 

5353 — 5:35 Neural Circuits and Synapses 

for Early Visual Processing. Jonathan B. Demb. 

Ophthalmology & Visual Science, Yale University, 

New Haven, CT 

6E 


481B Friedenwald Award and Lecture 

The Friedenwald Award is presented annually 

to recognize outstanding research in the basic or 

clinical sciences as applied to ophthalmology. 

— 6:30 Introduction. Joseph A. Izatt. Biomed 

Engineering/Ophthal, Duke University, Durham, 

NC *CR 

5354 — 6:35 Functional & Structural Optical 

Coherence Tomography. David Huang. Casey Eye 

Institute, Oregon Health & Science Univ, Portland, 

OR *CR 

Wednesday Lectures 

6:30 pm – 7:15 pm 


339

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Wednesday - ARVO

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