Thursday - ARVO

Thursday
May 9, 2013
LIFE-CHANGING RESEARCH
MAY 5 – 9 | SEATTLE

Thursday, May 9
8:30–10:30am
Room Symposium 10:30am–12:15pm 2–3:15pm
6B
501 Restoration of Vision [BI, VI,
RE, RC, PH, NT, LE, GL, GEN,
CO, CL] #5355-5361
523 Structure/Function [GL]
#5914-5920
548 ARVO/Alcon Keynote Series
6C
502 ER Stress and the Unfolded
Protein Response in Ocular
Health and Disease [BI, RE, RC,
PH, LE, GL, CO] #5362-5367
524 Imaging: Diagnostic and
Function [RE] #5921-5927
606-607
525 Clinical and Translational
Studies in Ocular Inflammation
[IM] #5928-5934
608
526 Anatomy Challenges for the
Future [AP] #5935-5941
609
527 Cataract II [LE] #5942-5948
611-614
528 Photoreceptor Degeneration
and Death [RC] #5949-5955
615-617
529 Refractive Error and Visual
Function: What Affects How We
See [CL] #5956-5962
618-620
530 Gene Therapy and Delivery
[PH] #5963-5969
TCC 303
532 Corneal Wound Repair and
Healing [CO] #5974-5980
TCC 305
533 Disruptions to Visual
Development: Detection,
Treatment and Consequences
[EY] #5981-5987
TCC LL 4/5
531 Beyond Large Print:
Advances in Accessibility and
Technology for the Visually
Impaired — Minisymposium [LV]
#5970-5973
Exhibit Halls, 10am–2pm
Networking Happy Hour,
Exhibit Halls, 12:30–2pm
Orlando Welcomes ARVO
2014 Kickoff Reception
East Lobby, 6th Floor
3:15–4pm
342

Thursday, May 10 n Posters
8:30–10:15am 10:30am–12:15pm
Session Session Program Board
Number Title Number Number
Session Session Program Board
Number Title Number Number
503 Posterior Segment Inflammation II [IM, BI] #5368-5398 (A0001-A0031)
504 Anterior Eye: Physiology and Pharmacology [PH, AP] #5399-5417 (A0043-A0061)
505 Ocular Surface in Health and Disease [CO] #5418-5452 (A0117-A0151)
506 Contact Lens II [CO, VI] #5453-5490 (A0152-A0189)
507 Image Processing and Segmentation Algorithms [MOI] #5491-5542 (B0001-B0052)
508 Improving Imaging and Ophthalmic Instrumentation [VI] #5543-5554 (B0053-B0064)
509 Diabetic Retinopathy and Vascular Biology II [RC] #5555-5580 (B0078-B0103)
510 Glia in Health and Disease [RC] #5582-5614 (B0105-B0137)
511 Intraocular Pressure [GL] #5615-5663 (C0001-C0049)
512 Pediatric Epidemiology [CL] #5664-5692 (C0135-C0163)
513 Myopia, CL [CL] #5693-5718 (C0164-C0189)
514 Vision Impairment [CL] #5719-5729 (C0190-C0200)
515 Chemical Composition and Physical Properties [LE] #5730-5753 (C0201-C0224)
516 Trauma [RE] #5754-5759 (D0001-D0006)
517 Laser/Intravitreal Treatment [RE] #5760-5763 (D0007-D0010)
518 Vitreoretinal Surgery III [RE] #5764-5810 (D0011-D0057)
519 Retina-RPE Transplantation [RE] #5811-5818 (D0071-D0078)
520 Imaging II, RE [RE] #5819-5873 (D0130-D0184)
521 Ocular and Orbital Tumors [AP] #5874-5899 (D0237-D0262)
522 Thyroid Eye Disease [EY] #5900-5913 (D0263-D0276)
534 Corneal Infection/Inflammation II [IM, CO] #5988-5998 (A0032-A0042)
535 Dry Eye and Lacrimal Gland V [CO, VI] #5999-6053 (A0062-A0116)
536 Inner Retina and Blood Vessels [VI] #6054-6066 (B0065-B0077)
537 Cell Biology of the Retina and RPE II [RC, VN] #6067-6108 (B0138-B0179)
538 Apoptosis and Cell Stress [BI] #6109-6118 (B0180-B0189)
539 Advancing Functional Assessment of the
Visual System [VN, VI] #6119-6144 (B0190-B0215)
540 Bipolar and Horizontal Cells [VN] #6145-6164 (B0216-B0235)
541 Genetic Risk Factors for Common Eye Disorders
with Complex Inheritance [GEN, VN] #6165-6215 (C0050-C0100)
542 Genetics II [GL] #6216-6249 (C0101-C0134)
543 Proliferative Vitreoretinopathy [RE] #6250-6262 (D0058-D0070)
544 AMD IV, RE [RE] #6263-6313 (D0079-D0129)
545 Retina: Physiology and Pharmacology [PH, BI, VN] #6314-6365 (D0185-D0236)
546 Oculoplastics: Eyelids [EY] #6366-6382 (D0277-D0293)
Poster board numbers indicate location:
Poster Area A and B = South Exhibit Hall; Poster Area C and D = North Exhibit Hall
12:30–1:30pm: All Posters — authors will be present at poster boards
12:30–2pm: Networking Happy Hour in Exhibit/Poster Halls.
343

344
NOTES
266
344
NOTES
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
344
NOTES
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
344
NOTES
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________

Thursday – Symposium – 5355 – 5367
6B
Thursday, May 09, 2013 8:30 AM-10:30 AM
Biochemistry/Molecular Biology / Clinical/
Epidemiologic Research / Cornea / Genetics /
Glaucoma / Lens / Nanotechnology and
Regenerative Medicine / Physiology/
Pharmacology / Retinal Cell Biology / Retina /
Visual Psychophysics / Physiological Optics
501 Restoration of Vision
The greatest contributions to life-changing research
may be the ability to restore vision. A number
of advancements in ophthalmic research have
already achieved this with corneal transplants,
retinal prosthetics, and gene therapy. In addition,
rapidly developing therapies using stem cells and
optogenetics are poised to offer new therapeutic
options for eye disease. An important element of
this work is the higher order processing that must
occur to incorporate the newly restored visual
input from the retina. This symposium provides
an overview of each of these areas by a dynamic
leader in the field. Each speaker will examine the
recent developments in their area and the exciting
advancements that will continue to provide new
opportunities for sight to individuals with blinding
eye disease.
Moderators: Machelle Pardue and David Berson
5355 — 8:30 Corneal Transplants. Donald T.
Tan. Singapore National Eye Center, Singapore,
Singapore *CR
5356 — 8:46 Stem Cell Transplantation.
Kang Zhang. Attn: Zhang Lab-Osler Ln, Univ Of
California, San Diego, La Jolla, CA *CR
5357 — 9:02 Stem Cell Therapy. Thomas A.
Reh. Dept of Biological Structure, University of
Washington, Seattle, WA
5358 — 9:18 Retinal Prosthetics. Eberhart
Zrenner. Institute for Ophthalmic Research, Centre
for Ophthalmology, Tuebingen, Germany *CR
5359 — 9:34 Range of retinal targets amenable
to AAV mediated gene therapy. William W.
Hauswirth. Dept. of Ophthalmology, University of
Florida College of Medicine, Gainesville, FL *CR
5360 — 9:50 Optogenetics. Botond Roska.
Friedrich Mieshcer Institute for Biomedical
Research, Basel, Switzerland *CR
5361 — 10:06 Learning to See Late in Life.
Pawan Sinha. Brain and Cognitive Sciences, MIT,
Cambridge, MA
6C
Thursday, May 09, 2013 8:30 AM-10:30 AM
Biochemistry/Molecular Biology / Cornea /
Glaucoma / Lens / Physiology/Pharmacology /
Retinal Cell Biology / Retina
502 ER Stress and the Unfolded Protein
Response in Ocular Health and Disease
Endoplasmic reticulum (ER) stress and the unfolded
protein response (UPR) have been implicated in a
variety of biological and pathological processes,
the latter including atherosclerosis, Alzheimer’s
disease, Parkinson’s disease, and diabetes, to name
but a few. In the eye, ER stress and the UPR have
been associated with several clinically significant
diseases, including glaucoma, age-related macular
degeneration, corneal dystrophy, and cataracts. In
addition, ER stress also is a normal process that
occurs during ocular development, such as in the
formation of the lens. This symposium will present
a succinct overview of the key features of ER stress
and UPR mechanisms, as well as the evidence
pointing to their involvement in ocular diseases and
the development of novel therapeutic approaches to
intervene in or prevent such diseases.
Moderators: Steven J. Fliesler and
Melinda K. Duncan
— 8:30 Introduction
5362 — 8:35 Protein Folding in the
Endoplasmic Reticulum and the Unfolded
Protein Response. Randal J. Kaufman.
Neuroscience & Stem Cell Research, Sanford-
Burnham Medical Research Institute, La Jolla, CA
5363 — 8:55 ER Stress and the Unfolded
Protein Response in Diabetic Retinopathy. Sarah
X. Zhang. Ophthalmology, SUNY-Buffalo, Buffalo,
NY
5364 — 9:14 Targeting ER Stress and the
Unfolded Protein Response in Treatment of
Primary Open Angle Glaucoma. Gulab S. Zode.
Univ of Iowa, Howard Hughes Medical Institute,
Iowa City, IA *CR
5365 — 9:33 The Unfolded Protein Response
in the Control of Normal Lens Development and
Cataract. Melinda K. Duncan. Biological Sciences,
University of Delaware, Newark, DE
5366 — 9:52 7-Ketocholesterol-mediated ER
Stress is an Age-Related Risk Factor in the
Pathogenesis of AMD. Ignacio R. Rodriguez.
LRCMB-MRDS, National Eye Institute, Bethesda,
MD
5367 — 10:11 Fuchs Endothelial Corneal
Dystrophy: Role of the Unfolded Protein
Response in Cellular Pathogenesis. Albert S. Jun.
Ophthal-Smith 5011, Johns Hopkins Wilmer Eye
Inst, Baltimore, MD *CR
Thursday Symposium
8:30 am – 10:30 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
345

5368 – 5386 – Thursday – Posters
Thursday Posters
8:30 am – 10:15 am
Exhibit Hall A0001-A0031
Thursday, May 09, 2013 8:30 AM-10:15 AM
Immunology/Microbiology / Biochemistry/
Molecular Biology
503 Posterior Segment Inflammation II
Moderator: Manfred Zierhut
5368 — A0001 Pivotal roles of EBI3 for the
initiation and maintenance of experimental
autoimmune uveitis. Atsunobu Takeda 1 , T.
Yoshimura 1 , E. Hasegawa 1 , S. Hirakawa 1 ,
T. Hisatomi 1 , K. Sonoda 2 , T. Ishibashi 1 .
1
Ophthalmology, Graduate School of Medical
Sciences, Kyushu University, Fukuoka, Japan;
2
Ophthalmology, Graduate School of Medicine,
Yamaguchi University, Ube, Japan
5369 — A0002 The effect of light on retinal
structure and the development of EAU in
the transgenic spontaneous model of uveitis.
Clare L. Corbett, E. Muckersie, J. V. Forrester.
Ophthalmology, University of Aberdeen, Aberdeen,
United Kingdom
5370 — A0003 Comparison of Pharmacokinetic
profiles of Sirolimus following Subconjunctival
or Intravitreal Administrations in Rabbits
and Humans. Masaaki Kageyama 1 , J. Naor 2 , H.
Takanaga 1 , L. J. Wilson 2 , N. Ihekoromadu 2 , A. A.
Khwaja 2 , S. Mudumba 1 . 1 Research & Development,
Santen Inc, Emeryville, CA; 2 Global Clinical
Development & Medical Affairs, Santen Inc,
Emeryville, CA *CR, f
5371 — A0004 Regulatory Effect of Interleukin
37 in Behcet’s disease. Zi Ye 1 , C. Wang 1 , A.
Kijlstra 2 , P. Yang 1 . 1 The First Affiliated Hospital
of Chongqing Medical University, Chongqing
Key Lab of Ophthalmology, Chongqing Eye
Institute, Chongqing, China; 2 University Eye Clinic
Maastricht, Maastricht, Netherlands
5372 — A0005 Efficacy of Rebamipide in
an Endotoxin-Induced Uveitis Model. Akira
Takamiya, H. Yokota, A. Shimouchi, A. Yoshida.
Ophthalmology, Asahikawa Medical Unversity,
Asahiawa, Japan *CR
5373 — A0006 Evidence-Based Analysis for the
Medical Treatment of Behçet’s Disease. Philip
I. Murray, M. Mubin, H. Knott, B. Markandey, N.
Joji, R. Malhotra, A. K. Denniston. Academic Unit
of Ophthalmology, University of Birmingham,
Birmingham, United Kingdom
5374 — A0007 Activation of the aryl
hydrocarbon receptor(AhR) inhibits Th1 and
Th17 cell immune response in Behcet’s disease.
Peizeng Yang 1 , C. Wang 1 , Z. Ye 1 , A. Kijlstra 2 .
1
Ophthal, The 1st Hosp, Chongqing Medical
University, Chongqing, China; 2 University Eye
Clinic Maastricht, Maastricht, Netherlands
5375 — A0008 Comparison of the Spectral
Domain Optical Coherence Tomography
Characteristics in Patients with Multifocal
Choroiditis and Punctate Inner Choroidopathy.
Roomasa Channa 1 , J. Wang 2 , M. A. Ibrahim 1 , J.
Lee 1 , D. Ferraz 1 , Y. J. Sepah 1 , M. G. Bittencourt 1 ,
R. Sophie 1 , E. Hatef Naimi 1 , Q. Nguyen 1 . 1 Retinal
Imaging Research and Reading Center, Johns
Hopkins University, Wilmer Eye Institute,
Baltimore, MD; 2 Dana Center, Johns Hopkins
University, Wilmer Eye Institute, Baltimore, MD
*CR
5376 — A0009 Fundus autofluorescence and
birdshot chorioretinopathy: a study of 162
patients. Astrid Queant, D. Monnet, A. P. Brezin.
Cochin Hospital, Paris, France
5377 — A0010 Treatment Paradigms in
Retinal Vasculitis. Jacqueline R. Busingye 1 ,
S. Schwartzman 2, 3 , J. M. Ackert 1 , T. Flynn 1 .
1
Ophthalmology, Mount Sinai School of Medicine,
New York, NY; 2 Rheumatology, Hospital for
Special Surgery, New York, NY; 3 Rheumatology,
Weill Medical College of Cornell University, New
York, NY *CR
5378 — A0011 Punctate Inner Choroidopathy
characterization by Enhanced Depth Imaging-
Optical Coherence Tomography: Quantitative
analysis of Retinal and Choroidal layers by
manual segmentation. Noa Fernandez Ledo, J.
Zarranz-Ventura, D. A. Sim, P. A. Keane, C. A.
Egan, P. J. Patel, M. C. Westcott, R. W. Lee, A.
Tufail, C. E. Pavesio. Medical Retina, Moorfields
Eye Hospital, London, United Kingdom *CR
5379 — A0012 Clinical course of a cohort of
patients with Punctate Inner Choroidopathy
managed with different modalities of treatment
in North Scotland. Shiao Wei Wong 1, 2 , P. Tyagi 2 ,
K. Khan 1 , S. Hewick 2 , L. Kuffova 1 . 1 Aberdeen
Royal Infirmary, NHS, Aberdeen, United Kingdom;
2
Raigmore Hospital, NHS, Inverness, United
Kingdom
5380 — A0013 Clinical Characteristics of
Vogt-Koyanagi-Harada Disease with Choroidal
Folds. Kouhei Hashizume 1 , Y. Imamura 2 , T.
Fujiwara 1 , S. Machida 1 , M. Ishida 2 , D. Kurosaka 1 .
1
Ophthalmology, Iwate Medical University,
Morioka, Japan; 2 Ophthalmology, Teikyo University
School of Medicine, Mizonokuchi Hospital,
Kawasaki, Japan
5381 — A0014 Clinical Outcomes of Vogt-
Koyanagi-Harada Disease at a Tertiary Center in
194 Patients: The KKESH Uveitis Survey Study
Group. Abdulaziz A. Alrushood 1, 4 , J. Arevalo 1, 2 ,
H. A. Al Dhibi 1 , Y. A. Al-Zahrani 1 , V. Gupta 1 , S.
M. Alsulaiman 1 , A. F. Lasave 3 , H. N. Al-Shamsi 1 .
1
Retina and Vitreous, KKESH, Riyadh, Saudi
Arabia; 2 Retina and Vitreous, Wilmer Eye Institute,
Baltimore, MD; 3 Retina and Vitreous, Clínica de
Oftalmologia de Cali and Hospital Universitario del
Valle, cali, Cambodia; 4 Ophthalmology, Dammam
universty, dammam, Saudi Arabia *CR
5382 — A0015 Choroidal Bulging in Patients
with Vogt-Koyanagi-Harada and Long-standing
Disease. Viviane M. Sakata 1 , F. G. da Silva 1 ,
C. Hirata 1 , E. Olivalves 1 , W. Y. Takahashi 1 , R.
A. Costa 2, 3 , J. H. Yamamoto 1 . 1 Ophthalmology,
Hospital das Clínicas da Faculdade de Medicina
da Universidade São Paulo, São Paulo, Brazil;
2
Division of Macula: Imaging & Treatment, Centro
Brasileiro de Ciências Visuais, Belo Horizonte,
Brazil; 3 Ophthalmology, Faculdade de Medicina
da Universidade de Ribeirão Preto, Ribeirão Preto,
Brazil *CR
5383 — A0016 Sympathetic ophathalmia:
Histopathological and Immunohistochemical
Characteristics. Hassan Aziz, H. W. Flynn, R. C.
Young, J. L. Davis, S. R. Dubovy. Bascom Palmer
Eye Institute, Miami, FL
5384 — A0017 Natural history of Multiple
Evanescent White Dot Syndrome: a
multimodality imaging study. Mafalda Macedo 1, 2 ,
S. Vaz-Pereira 1, 3 , G. De Salvo 1 , B. Pal 1 . 1 Medical
Retina Department, Moorfields Eye Hospital,
London, United Kingdom; 2 Department of
Ophthalmology, Hospital de Santo Antonio-CHP,
Porto, Portugal; 3 Department of Ophthalmology,
Hospital de Santa Maria, Lisbon, Portugal
5385 — A0018 A retrospective analysis of the
natural history and management of serpiginous
choroidopathy (SC) in Australia and New
Zealand. Anthony J. Hall 1, 2 , J. Toniolo 1, 2 , J.
Sims 4 , S. Fraser-Bell 5 , J. Khan 6 , C. Younan 7 ,
B. Kent-Smith 8 , S. Young 9 , E. Paul 2 , L. Lim 3 .
1
Ophthalmology, Alfred Hospital, Melbourne,
Prahran, VIC, Australia; 2 Faculty of Medicine,
Nursing and Health Science, Monash University,
Melbourne, VIC, Australia; 3 Centre for Eye
Research Australia, University of Melbourne,
Melbourne, VIC, Australia; 4 Auckland Eye,
Auckland, New Zealand; 5 Sydney Eye Hospital,
Sydney, NSW, Australia; 6 Ophthalmology,
Royal Perth Hospital, Perth, WA, Australia;
7
Ophthalmology, Westmead Hospital, Sydney,
NSW, Australia; 8 Ophthalmology, Whangarei
Area Hospital, Whangarei, New Zealand;
9
Ophthalmology, Repatriation General Hospital,
Sydney, NSW, Australia
5386 — A0019 MicroRNA-146a and Ets-
1 gene polymorphisms in ocular Behcet’s
disease and Vogt-Koyanagi-Harada syndrome.
Qingyun Zhou 1 , A. Kijlstra 2 . 1 Ophthalmology, The
First Affiliated Hospital of Chongqing Medical
University, Chongqing, China; 2 Eye Research
Institute Maastricht, Maastricht, Netherlands
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
346

Thursday – Posters – 5387 – 5408
5387 — A0020 Characteristics, Complications,
and Surgical Outcomes of Panuveitis in 400
patients (727 eyes) over 25 Years: The KKESH
Uveitis Survey Study Group. J Fernando
Arevalo 1, 2 , A. F. Lasave 3 , H. N. Al-Shamsi 2 , S. M.
Al Sulaiman 2 , A. A. Alrushood 2 , Y. A. Alzahrani 2 ,
V. Gupta 2 , A. M. Al-Mahmood 4 , H. A. Al Dhibi 2 .
1
Retina Division, Wilmer Eye Institute, Johns
Hopkins University School of Medicine, Baltimore,
MD; 2 Vitreoretinal Division, King Khaled Eye
Specialist Hosp, Riyadh, Saudi Arabia; 3 Clínica de
Oftalmologia de Cali and Hospital Universitario
del Valle, Cali, Colombia; 4 Anterior Segment and
Uveitis Division, King Khaled Eye Specialist
Hospital, Riyadh, Saudi Arabia *CR
5388 — A0021 Comparison of the effect
of Dexamethasone drug delivery system in
macular edema in patients with uveitis or retinal
vein occlusion. Thomas Ness, D. Boehringer, A.
Pielen, S. Heinzelmann. University Eye Hospital,
University of Freiburg, Freiburg, Germany *CR
5389 — A0022 Involvement of Vitreous in
Castleman’s Disease. Sunju Park, M. S. Katz, D.
C. Gritz. Ophthalmology and VIsual Sciences,
AECOM/Montefiore Medical Center, Bronx, NY
5390 — A0023 The use of Bromfenac for the
Treatment of Macular Edema Secondary to Non-
Infectious Uveitis. Joanna Saade, M. Abdulaal, R.
N. Hamam. American University of Beiirut, Beirut,
Lebanon
5391 — A0024 Assessment of Changes in
Quality of Life Among Patients in the SAVE
Study - Sirolimus As Therapeutic Approach
To UVEItis: A Randomized Study To Assess
The Safety And Bioactivity Of Intravitreal And
Subconjunctival Injections Of Sirolimus In
Patients With Non-infectious Uveitis. Erin Vigil,
Y. J. Sepah, O. O. Agbedia, A. L. Watters, M. A.
Sadiq, M. Ansari, M. G. Bittencourt, M. A. Ibrahim,
Q. Nguyen. The Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD *CR, f
5392 — A0025 Mycophenolate Mofetil in
Refractory Non-infectious Uveitis. Manoel
Gusmao Isidro, V. M. Sakata, D. C. Cavalcanti, J.
Zaghetto, E. Olivalves, C. Hirata, J. H. Yamamoto.
Hospital das Clinicas da Faculdade de Medicina da
Universidade São Paulo, São Paulo, Brazil
5393 — A0026 Study of the Prevalence of
Ophthalmology Uveitis Tertiary Hospital in
Teresina-Pi. Leonardo Pinheiro Teixeira 1 , L.
Rosa Ribeiro Cunha 1 , C. Dar’k Amorim Teles 1 , V.
Cortizo 2 . 1 Faculdade de Saúde Ciencias Humanas e
Tecnológicas do Piauí - NOVAFAPI, Teresina- PI,
Brazil; 2 Universidade Federal do Piauí - UFPI,
Teresina- PI, Brazil
5394 — A0027 Decline in Ocular Toxoplasmosis
in the Midwestern United States. Asim Farooq 1 , J.
H. Hou 1 , S. Patel 1, 2 , H. Tessler 1 , D. A. Goldstein 1, 3 .
1
Ophthalmology, Illinois Eye & Ear Infirmary,
Chicago, IL; 2 Ophthalmology, Weill Cornell
Medical College, New York, NY; 3 Ophthalmology,
Feinberg School of Medicine, Northwestern
University, Chicago, IL *CR
5395 — A0028 Treatments and visual
outcomes in patients with ocular sarcoidosis.
Hisae Nakahara 1, 2 , T. Kaburaki 1 , M. Takamoto 1 ,
A. Yoshida 3 , K. Okinaga 1 , J. Numaga 1 , K.
Ando 1 , Y. Fujino 1, 4 , H. Kawashima 3 , S. Amano 1 .
1
Ophthalmology, Univ of Tokyo School of Med,
Bunkyo-ku, Japan; 2 Ophthalmology, Senpo
Tokyo Takanawa Hospital, Minato-ku, Japan;
3
Ophthalmology, Jichi Medical University,
Shimotsuke-shi, Japan; 4 Ophthalmology, Tokyo
Kosei Nenkin Hospital, Shinjuku-ku, Japan *CR
5396 — A0029 The serum angiotensin
converting enzyme and lysozyme levels in
patients with ocular involvement of ankylosing
spondylitis, behcet disease, sarcoidosis and latent
tuberculosis. Ozlem Gurses 1 , E. Karaismailoglu 1, 2 .
1
Ophthalmology, Middle East Technical University,
Oran ankara, Turkey; 2 Statistics, Hacettepe
University Medical Faculty, Ankara, Turkey f
5397 — A0030 Inflammatory activity and
visual outcomes in patients treated with
cryotherapy for pars planitis. Benjamin C. Chaon,
J. C. Folk, E. H. Sohn. Ophthalmology and Visual
Sciences, University of Iowa, Iowa City, IA
5398 — A0031 Predictive factors for postoperative
complications in diagnostic vitrectomy.
Michael Karampelas 1 , R. Moya 1 , D. A. Sim 1, 2 , J.
Zarranz-Ventura 1 , D. G. Charteris 1 , R. W. Lee 1, 3 ,
C. E. Pavesio 1, 2 . 1 NIHR Biomedical Research
Centre for Ophthalmology, Moorfields Eye
Hospital NHS Foundation Trust, London, United
Kingdom; 2 University College London, Institute
of Ophthalmology, London, United Kingdom;
3
Department of Clinical Sciences, University of
Bristol, Bristol, United Kingdom *CR
Exhibit Hall A0043-A0061
Thursday, May 09, 2013 8:30 AM-10:15 AM
Physiology/Pharmacology / Anatomy/Pathology
504 Anterior Eye: Physiology and
Pharmacology
Moderator: Caterina Gagliano
5399 — A0043 Induction of MAPK
Phosphatase-1 by the Novel Selective
Glucocorticoid Receptor Agonist Mapracorat
Suppresses Inflammatory Signaling Pathways in
Human Corneal Epithelial Cells. Megan E. Cavet,
K. L. Harrington, T. R. Vollmer, M. Richardson,
J. Zhang. Pharmaceutical R&D, Bausch & Lomb,
Rochester, NY *CR
5400 — A0044 Pirfenidone nanoparticles
improve healing and prevent corneal scarring
following alkali burn. Sarbani Hazra 1 , S.
Chowdhury 2 , R. Guha 2 , T. Ruchit 3 , U. B. Kompella 3 ,
A. Konar 2 . 1 Veterinary Surgery & Radiology,
WBUAFS, Kolkata, India; 2 Animal Facilities,
Indian Institute of Chemical Biology, Kolkata,
India; 3 Department of Pharmaceutical Sciences,
University of Colorado Anschutz Medical Campus,
Aurora, CO *CR
5401 — A0045 The effect of sulindac
liposome on inflammation induced corneal
neovascularization. Jun-Sub Choi, C. Joo.
Ophthalmology & Visual Science, Catholic Univ
Korea Coll of Med, Seoul, Republic of Korea
5402 — A0046 Application of
phosphoproteomic analysis in myopic chick
retina. Fengjuan Yu 1 , K. Li 1 , T. Lam 1 , C. To 1, 2 .
1
Laboratory of Experimental Optometry, School of
Optometry, the HongKong Polytechnic University,
Kowloon, Hong Kong; 2 State Key Laboratory of
Ophthalmology, Zhongshan Ophthalmic Centre,
SunYat-sen University, Guangzhou, China
5403 — A0047 Gender, Ethnicity, and Time
After Awakening Affect Tear Film Cytokine
Concentrations. Meng C. Lin 1, 2 , J. O. Niimi 1 , N.
A. McNamara 2, 3 , Y. Zhou 1 , J. Shumaker 1 , H. M.
French 1 , T. Leung 1 , S. L. Wang 1 , K. Siemasko 4 ,
M. E. Stern 4 . 1 School of Optometry, Clinical
Research Center, University of California, Berkeley,
Berkeley, CA; 2 School of Optometry, University
of California, Berkeley, Berkeley, CA; 3 Francis
I. Proctor Foundation, University of California,
San Francisco, San Francisco, CA; 4 Allergan, Inc,
Irvine, CA *CR
5404 — A0048 Cross-Species and Cross-Age
Comparison of Esterase Mediated Metabolism
in Vitreous Humor: Human versus Rabbit, Dog
and Monkey. Mayssa Attar, J. Shen, M. S. Kim, Q.
Radojicic. Drug Safety Evaluation, Allergan, Irvine,
CA *CR
5405 — A0049 Bicarbonate sensitive soluble
adenylyl cyclase (sAC) generates the cAMP
in aqueous humor (AH). Yong Lee 1 , Y. Lee 1 , L.
Ramos-Espiritu 3 , L. Y. Marmorstein 1 , J. Buck 3 , L.
Levin 3 , A. D. Marmorstein 1, 2 . 1 Ophthalmology and
Vision Science, University of Arizona, Tucson, AZ;
2
Physiology, University of Arizona, Tucson, AZ;
3
Pharmacology, Weill Cornell College of Medicine,
New York, NY *CR
5406 — A0050 Beneficial Assessment of A
Combined Tropicamide and Various Oxime
Treatments Against Miosis and Visual
Dysfunction Following Ocular Exposure to the
Nerve Agent Sarin.
5407 — A0051 Dexamethasone Modifies
Viability of Mitomycin C-Treated Tenon’s
Fibroblasts. Shu-Wen Chang 1, 2 , W. Ho 1 , T. Chen 1 , S.
Chou 3 . 1 Department of Ophthalmology, Far Eastern
Memorial Hospital, New Taipei City, Taiwan;
2
Department of Ophthalmology, National Taiwan
University Hospital, Taipei, Taiwan; 3 Department of
Medical Research, Far Eastern Memorial Hospital,
New Taipei City, Taiwan
5408 — A0052 TRPV1 and corneal Pain. Eric
Senning, S. E. Gordon. Physiology and Biophysics,
University of Washington, Seattle, WA
Thursday Posters
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
347

5409 – 5430 – Thursday – Posters
Thursday Posters
8:30 am – 10:15 am
5409 — A0053 Different Roles of Carbonic
Anhydrase in Human vs. Bovine Corneal
Endothelial Transport. Thomas M. Malikowski 1 ,
M. E. Duffey 2 , S. P. Patel 3, 4 . 1 School of Medicine
& Biomedical Sciences, University at Buffalo,
Buffalo, NY; 2 Physiology & Biophysics, University
at Buffalo, Buffalo, NY; 3 Ophthalmology, SUNY
Eye Institute, University at Buffalo, Buffalo, NY;
4
Research Service, VAWNYHS, Buffalo, NY *CR
5410 — A0054 ROCK Inhibitor Y-27632
Enhances the Mucin Secretion from Goblet
Cells Derived from Limbal Stem Cells. Won
Seok Choi 1 , E. Chung 2 , T. Chung 2 , J. Hyon 3, 4 , W.
Wee 3 , Y. Shin 1 . 1 Ophthalmology, Hallym University
College of Medicine, Seoul, Republic of Korea;
2
Ophthalmology, Sungkyunkwan University
School of Medicine, Seoul, Republic of Korea;
3
Ophthalmology, Seoul National University
College of Medicine, Seoul, Republic of Korea;
4
Ophthalmology, Seoul National University
Bundang Hospital, Seoul, Republic of Korea
5411 — A0055 Impact of Acute Exposure to
High Altitude on Anterior Chamber Geometry.
M Dominik Fischer 1, 2 , G. Willmann 1 , A. Schatz 1 ,
K. Schommer 3 , A. Zhour 1 , E. Zrenner 1 , K. Bartz-
Schmidt 1 , F. Gekeler 1 . 1 Centre for Ophthalmology,
University Hospital Tuebingen, Tuebingen,
Germany; 2 Nuffield Laboratory of Ophthalmology,
University of Oxford, Oxford, United Kingdom;
3
Department of Sports Medicine, Medical Clinic,
University Hospital Heidelberg, Heildelberg,
Germany *CR
5412 — A0056 Evaluation of Feature Detectors
and Descriptors on the Iris. Sandro I. De Zanet 1, 2 ,
M. Rueegsegger 1, 2 , T. Rudolph 1, 2 , S. Wolf 2 , J. H.
Kowal 1, 2 . 1 Ophthalmic Technologies ARTORG
Center, University of Bern, Bern, Switzerland;
2
Department of Ophthalmology, University of Bern,
Bern, Switzerland *CR
5413 — A0057 Tear Film and Lid Margins
in Over-Blink. Heiko Pult 2, 1 , B. H. Riede-Pult 2, 1 ,
C. A. Blackie 3, 4 , P. J. Murphy 5 , D. R. Korb 3, 4 .
1
School of Optometry and Vision Sciences, Cardiff
University, Cardiff, United Kingdom; 2 Dr. Heiko
Pult - Optometry and Vision Research, Weinheim,
Germany; 3 TearScience Inc., MA, USA, Boston,
MA; 4 Korb Associates, Boston, MA; 5 School of
Optometry and Vision Sciences, University of
Waterloo, Waterloo, ON, Canada *CR
5414 — A0058 The role of reactive oxygen
species on cytotoxicity of moxifloxacin and
benzalkonium chloride on human corneal
epithelial cells. Ta-Ching Chen, F. Hu. National
Taiwan University Hospital, Taipei, Taiwan
5415 — A0059 Growth factor secretion
in human keratocyte cultures following
photodynamic inactivation (PDI). Tanja
Stachon 1 , J. Wang 1, 2 , A. Langenbucher 3 , B. Seitz 1 ,
N. Szentmáry 1 . 1 Department of Ophthalmology,
Saarland University Hospital, Homburg/Saar,
Germany; 2 Department of Ophthalmology, Renmin
Hospital of Wuhan University, Wuhan, China;
3
Experimental Ophthalmology, Saarland University,
Homburg/Saar, Germany
5416 — A0060 Efficacy of a novel synthetic
topical tetrapeptide on eliciting analgesia
subsequent to experimentally induced chemical
corneal injury. Bruce I. Gaynes, M. Russo, D.
Goldmeier. Ophthalmology, Loyola University
Chicago, Maywood, IL *CR
5417 — A0061 Enantiomeric Separation,
Ophthalmic Formulations and Mydriatic
Activity Oo Cyclopentolate Hydrochloride.
Danilo Aleo 1 , S. Mangiafico 1 , M. G. Saita 1 , B.
Melilli 1 , M. G. Cro 1 , S. Mangiafico 1 , N. D’Antona 2 ,
G. Nicolosi 2 . 1 R&D, Medivis, Catania, Italy;
2
Istituto Chimico Biomolecolare, CNR, Catania,
Italy *CR
Exhibit Hall A0117-A0151
Thursday, May 09, 2013 8:30 AM-10:15 AM
Cornea
505 Ocular Surface in Health
and Disease
Moderator: Mary Ann Stepp
5418 — A0117 A Modified Delphi Technique
to Obtain Consensus on the Scoring of Ocular
Surface Disease Damage and Activity Indices.
Priscilla Mathewson, G. P. Williams, P. J. Tomlins,
S. Kolli, P. I. Murray, S. Rauz. Academic Unit of
Ophthalmology, University of Birmingham, West
Midlands, United Kingdom
5419 — A0118 Indications and Outcomes of
the Needle Dissection Technique for the Full
Gundersen Conjunctival Flap in 76 eyes. Heidrun
Gollogly, L. Maguire. Ophthalmology, Mayo Clinic,
Rochester, MN
5420 — A0119 Characterization of patients
with ocular chronic graft-versus-host disease
and evaluation of a new grading scale. Christiane
Blecha 1 , D. Wolff 2 , D. A. Maerker 1 , H. Helbig 1 , T.
Dietrich-Ntoukas 1 . 1 Ophthalmology, University
Hospital Regensburg, Regensburg, Germany;
2
Hematology and Oncology, University Hospital
Regensburg, Regensburg, Germany
5421 — A0120 Proliferative Gain of Function
of Stromal Fibroblasts via SDF-1 in Pathogenesis
of Pterygia. Kyoung Woo Kim, S. Park, J. Kim.
Department of Ophthalmology, Chung-Ang
University Hospital, Seoul, Republic of Korea
5422 — A0121 Behaviour of Conjunctival
Goblet Cells after allogenic Hematopoietic
Stem Cell Transplantation. Alexandra B. Knoll 1 ,
E. Jakob 1 , K. Brandauer 1 , B. C. Dobner 1 , U.
Hegenbart 3 , P. Dreger 3 , G. Auffarth 2 , F. Mackensen 1 .
1
Interdisciplinary Uveitis Center, University
Hospital Heidelberg, Heidelberg, Germany;
2
Ophthalmology, University Hospital Heidelberg,
Heidelberg, Germany; 3 Heamatology, University
Hospital Heidelberg, Heidelberg, Germany *CR
5423 — A0122 Differences among signs and
symptoms of dry eye among patients with
Sjogren’s syndrome, blepharitis, or no ocular
surface disease. Bridgette E. McCabe 1 , M.
Massaro-Giordano 1 , N. M. Fuerst 1 , M. Pistilli 1 ,
G. Ying 1 , I. Macchi 2, 1 , R. Salvo 1 , V. Y. Bunya 1 .
1
Scheie Eye Institute- Ophthalmology, University
of Pennsylvania, Philadelphia, PA; 2 Campus
Biomedico Rome, Rome, Italy *CR
5424 — A0123 Evaluation of a protocol
for isolation and expansion of murine and
rat lacrimal gland mesenchymal stem cells.
Mathias Roth, A. Kunze, G. Geerling, S. Schrader.
Ophthalmology, University of Düsseldorf,
Düsseldorf, Germany *CR
5425 — A0124 Long-Term Outcomes of
Patients with Ocular Surface Stem Cell
Transplant: 20 years follow-up. Kunal Suri,
S. C. Kaufman. Ophthalmology and Visual
Neurosciences, University of Minnesota,
Minneapolis, MN *CR
5426 — A0125 Mild-moderate dry eye patients
exhibit ocular surface temperature lower than
normal subjects. Giuseppe Giannaccare, P.
Versura, M. Grillini, E. C. Campos. Ophthalmology
Unit, DIMES Department, Alma Mater Studiorum
University of Bologna and S.Orsola-Malpighi
Teaching Hospital, Bologna, Italy
5427 — A0126 Ocular Surface Changes in
Glaucomatous Patients Treated with and without
Preservatives beta-Blockers. Serena Telani 1 , M. M.
Iester 1 , P. Frezzotti 2 , M. Figus 3 , P. Fogagnolo 4 , A.
Perdicchi 5 , A. Ferreras 6 , C. Traverso 1 . 1 University
Eye Clinic, Genova, Italy; 2 University Eye Clinic,
Siena, Italy; 3 University Eye Clinic, Pisa, Italy;
4
University Eye Clinic, Milano, Italy; 5 University
Eye Clinic, La Sapienza, Rome, Italy; 6 Univerisity
Eye Clinic, Zaragoza, Spain *CR
5428 — A0127 Ocular surface findings
associated to clinical signs of hyperandrogenism
assessed by an innovative videodermoscopic
method. Ilaria Macchi 1 , L. Guccione 2 , F.
Mantelli 1 , A. Micera 3 , C. G. Moretti 2 , S. Bonini 1 .
1
Ophthalmology, Campus Biomedico Unversity,
Rome, Italy; 2 Endocrinology, San Giovanni Calibita
Fatebenefratelli Hospital, Rome, Italy; 3 IRCCS GB
Bietti, Rome, Italy *CR, f
5429 — A0128 PROSE treatment for Ocular
Surface Disease in patients with history of
Stevens-Johnson Syndrome/Toxic Epidermal
Necrolysis. Thanos D. Papakostas 1 , H. Le 2 , J.
Chodosh 1 , D. S. Jacobs 2, 1 . 1 Ophthalmology,
Massachusetts Eye & Ear Infirmary, Boston, MA;
2
Boston Foundation for Sight, Needham, MA *CR
5430 — A0129 Assessment of the EyePRIM
Device for Conjunctival Impression for Flow
Cytometry. Paul J. Tomlins 1 , P. Roy 2 , J. Curnow 1 ,
S. Rauz 1 . 1 Centre for Translational Inflammation
Research, University of Birmingham, Birmingham,
United Kingdom; 2 Opia Technologie, Paris, France
*CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
348

Thursday – Posters – 5431 – 5455
5431 — A0130 Relationships of meibomian
gland dysfunction and cardiovascular disease
risk factors in a middle-aged population. Hung-
Chi Chen 1, 2 , C. Chen 2 , H. Chen 3 , Y. Hwang 1, 2 , H.
Lin 1 , D. H. Ma 1 . 1 Ophthalmology, Chang Gung
Memorial Hospital, Taoyuan County, Taiwan;
2
Medicine, Chang Gung University College of
Medicine, Taoyuan, Taiwan; 3 Internal Medicine,
Taipei City Hospital-Heping Branch, Taipei, Taiwan
5432 — A0131 Antibacterial Activity of
Lysozyme in Hyperosomolar Conditions.
Poonam Mudgil, J. Whitehall. School of Medicine,
University of Western Sydney, Penrith, NSW,
Australia
5433 — A0132 Treatment of Ocular
Surface Failure Due to Limbal Stem Cell
Deficiency by Cultivated Limbal Epithelial
Cell Transplantation (CLET). Beatriz Eugenia
E. Ramirez Villagran 1 , M. F. Pastor 3 , J. M.
Herreras 1, 2 , I. Pérez 1 , J. García-Sancho 3 , A.
Sanchez 3 , M. Calonge 1, 2 . 1 Ocular Surface Group,
IOBA-University of Valladolid, Valladolid, Spain;
2
CIBER-BBN (Biomedical Research Networking
Center in Bioengineering, Biomaterials and
Nanomedicine), Spain, Spain; 3 IBGM-University of
Valladolid, Valladolid, Spain *CR
5434 — A0133 Prevention, Prophylaxis,
and Treatment of Ocular Surface Disease in a
Tertiary Care Inpatient Setting: Identifying
Patients at Risk. Jesse T. McCann, I. Belinsky, L.
Park. NYU Medical Center, New York, NY
5435 — A0134 Risk Factors of Severe
Acanthamoeba Keratitis. Machiko Shimmura-
Tomita, H. Takano, N. Kinoshita, F. Toyoda, A.
Ota, A. Kakehashi. Ophthalmology, Jichi Medical
University Saitama Medical Center, Saitama, Japan
5436 — A0135 Evaluation of different
applicator-systems for autologous serum eyedrops.
Alexander Kunze, K. Spaniol, G. Geerling.
Ophthalmology, University Hospital Duesseldorf,
Duesseldorf, Germany *CR
5437 — A0136 Standardized Quantification
of Inflammatory Biomarker HLA-DR for
Multicenter Clinical Trials of Ocular Surface
Disease. Penny A. Asbell 1 , S. P. Epstein 1 , N.
Gadaria-Rathod 1 , Y. Wei 1 , M. G. Maguire 2 .
1
Ophthalmology, Mount Sinai School of Medicine,
New York, NY; 2 Ophthalmology, University of
Pennsylvania, Philadelphia, PA *CR
5438 — A0137 Cytokine tear film expression in
patients with primary and recurrent pterygium.
Victor M. Bautista, N. Rangel-Acosta, N. López-
Espinosa, A. Nava-Castañeda. Microbiology and
Ocular Proteomics, Inst de Ophthal Conde de
Valenciana, Mexico, Mexico
5439 — A0138 Effectiveness and safety of
intralesional injection of 0.01 mg Mitomycin
C one month prior to bare sclera excision for
pterygium treatment. Brian Tieu, M. Kapur.
UTMB, Galveston, TX
5440 — A0139 Extended Soft Bandage Contact
Lenses Therapy for Ocular Graft-Versus-
Host Disease. Yichen Sun 1, 4 , Y. Inamoto 3 , J. P.
Sheehan 1 , P. Li 2 , R. K. Wang 1, 2 , S. Lee 3 , T. T. Shen 1, 2 .
1
Ophthalmology, University of Washington, Seattle,
WA; 2 Bioengineering, University of Washington,
Seattle, WA; 3 Fred Hutchinson Cancer Research
Center, Seattle, WA; 4 Graduate Institute of Clinical
Medicine, National Taiwan University, Taipei,
Taiwan *CR, f
5441 — A0140 Three-dimensional volumetric
reconstruction of the mouse diabetic cornea.
Danielle M. Robertson 1 , M. Petroll 1 , M. Zhu 1 ,
V. Koppaka 1, 2 . 1 Ophthalmology, Univ Texas
Southwestern Med Ctr, Dallas, TX; 2 Pharmacy,
University of Colorado Denver, Denver, CO
5442 — A0141 Rat Exorbital Lacrimal Gland
Ducts Have Gastrin Receptors. Mortimer
Lorber 1 , E. C. Permaul 2 , S. Sen 2 , D. Berry 2 .
1
Pharmacology & Physiology, Georgetown Univ
School of Medicine, Washington, DC; 2 Lombardi
Comprehensive Cancer Center, Georgetown Univ
School of Medicine, Washington, DC
5443 — A0142 Changes in corneal innervations
after herpes simplex virus type 1 (HSV-1)
latency established with different reactivation
phenotypes. Jiucheng He 1, 2 , R. Cosby 1, 2 , J.
M. Hill 1, 2 , H. E. Bazan 1, 2 . 1 Ophthalmology &
Neuroscience Ctr, LSU Health Sciences Center,
New Orleans, LA; 2 LSU Eye Center, LSU Health
Sciences Center, New Orleans, LA
5444 — A0143 Assessment of the Eyeprim ®
Device for Conjunctival Impression and
PCR. Pierre Roy 1 , H. Groux 2 , F. Cottrez 2 , L.
Protat 1 . 1 OPIA Technologies SAS, Paris, France;
2
IMMUNOSEARCH, Grasse, France *CR
5449 — A0148 A Plaque Method for Direct
and Sensitive Enumeration of Surviving
Acanthamoeba During Biocidal Efficacy and
Regimen Testing of Contact Lens Disinfection
Solutions. Shawn C. Lynch, J. G. Carr, C. Kovacs,
M. A. Dehmler, T. Bassage, W. Haas, T. W. Morris.
Bausch & Lomb, Rochester, NY *CR
5450 — A0149 Atypical Pathogens Observed
in Recent Clinical Studies of Bacterial
Conjunctivitis. Lynne S. Gearinger 1 , C. M.
Sanfilippo 1 , L. Zhang 2 , W. Haas 1 , T. L. Comstock 3 ,
T. W. Morris 1 . 1 Microbiology and Sterilization
Sciences, Bausch & Lomb, Inc, Rochester, NY;
2
Global Clinical Operations, Bausch & Lomb, Inc,
Rochester, NY; 3 Global Medical Affairs, Bausch &
Lomb, Inc, Rochester, NY *CR, f
5451 — A0150 A Parallel-Group Study
Evaluating the Safety and Efficacy of
BrimonidineTartrate 0.025% Ophthalmic
Solution in a Population of Adult and Geriatric
Subjects. Gerald Horn 1 , M. J. Chapin 2 , P. J.
Gomes 2 . 1 Eye Therapeutics, Schaumburg, IL; 2 Ora,
Inc, Andover, MA *CR, f
5452 — A0151 Evolution in post transplant
patients with Herpetic Keratitis in Hospital
Fundacion Nuestra Señora de la Luz. cristina C.
fernandez 1 , C. Pacheco-Del-Valle 2 , A. Babayan 3 ,
O. Baca 4 , R. Velasco 5 . 1 cornea, Hospital Fundacion
Nuestra Señora de la Luz, Distrito Federal, Mexico;
2
cornea, Hospital Fundacion Nuestra Señora de la
Luz, Distrito Federal, Mexico; 3 cornea, Hospital
Fundacion Nuestra Señora de la Luz, Distrito
Federal, Mexico; 4 cornea, Hospital Fundacion
Nuestra Señora de la Luz, Distrito Federal, Mexico;
5
cornea, Hospital Fundacion Nuestra Señora de la
Luz, Distrito Federal, Mexico
5445 — A0144 Classification of the ocular
surface manifestations in patients with Stevens-
Johnson Syndrome. Tais H. Wakamatsu, M. S.
Santos, T. P. Barreiro, C. C. Farias, F. E. Hirai, J.
A. Gomes. Ophthalmology, Federal University of
São Paulo, Sao Paulo, Brazil *CR
5446 — A0145 Ocular surface in Sjögren’s
syndrome. Hayette Rebika 1 , S. Lazreg 2 . 1 CHU
Clermont Ferrand, Clermont Ferrand, France;
2
Cabinet Dr Lazreg, Blida, Algeria
5447 — A0146 Treatment of Ocular cGVHD
with PRP: a confocal microscopy study. Marco
Marenco 1 , E. Gerace 1 , A. Plateroti 1 , C. Colica 1 ,
G. Ferrazza 2 , L. De Felice 2 , E. M. Vingolo 1 , M.
Gharbiya 1 , R. Plateroti 1 . 1 Ophthalmology, Sapienza
University of Roma, Rome, Italy; 2 Hematology,
Sapienza University of Roma, Rome, Italy
5448 — A0147 Angiogenin is a Requirement for
Active Stromal tissue Formation and Recurrence
of Pterygium. Jae Chan Kim, K. Kim, S. Park,
Y. Chun, S. Wee. Department of Ophthalmology,
Chung-Ang University Hospital, Seoul, Republic
of Korea
Exhibit Hall A0152-A0189
Thursday, May 09, 2013 8:30 AM-10:15 AM
Cornea / Visual Psychophysics /
Physiological Optics
506 Contact Lens II
Moderators: J. Martin Heur and Vasile Diaconu
5453 — A0152 Corneal confocal and
topographical changes with use of rigid contact
lens in keratoconus patients following collagen
cross linking. Sri Vatsa Sehra, J. S. Titiyal, R.
Tandon, N. Sharma, R. Sinha. Dr Rajendra Prasad
Centre for Ophthalmic Sciences, All India Institute
of Medical Sciences, New Delhi, India
5454 — A0153 Is the Use of an Integrating
Sphere Really Desirable When Measuring
Contact Lens Transmittance? Claude J.
Giasson 1, 2 , C. Deschênes 1 , V. Diaconu 1 . 1 School of
Optometry, University of Montreal, Montreal, QC,
Canada; 2 LOEX, CHA, Quebec, QC, Canada
5455 — A0154 Peripheral Defocus with
Spherical and Bifocal Soft Contact Lenses. David
A. Berntsen, C. E. Kramer. College of Optometry,
University of Houston, Houston, TX *CR
Thursday Posters
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
349

5456 – 5478 – Thursday – Posters
5456 — A0155 Functional and visual
improvement with Prosthetic Replacement of
the Ocular Surface Ecosystem (PROSE) scleral
lenses for irregular corneas. Jennifer C. Lee, G.
B. Chiu, D. Bach, S. R. Bababeygy, J. A. Irvine, J.
M. Heur. Ophthalmology, Doheny Eye Institute
at Keck School of Medicine of the University of
Southern California, Los Angeles, CA
5457 — A0156 Migrating versus Stationary
Pressure Experiments in Lubricity
Measurements of Hydrogels. Alison C. Dunn 1 ,
J. M. Uruena 1 , J. Pruitt 2 , T. E. Angelini 1 ,
W. G. Sawyer 1 . 1 Mechanical and Aerospace
Engineering, University of Florida, Gainesville,
FL; 2 Biocompatibility Projects, Alcon Vision Care
Research, Johns Creek, FL *CR
5458 — A0157 Struggle with Soft Contact
Lens Wear Addressed by Refitting with Daily
Disposable Lenses. Robin L. Chalmers, S. B.
Hickson-Curran, L. J. Keay, W. Gleason, R.
Albright. Clinical Trial Consultant, Atlanta, GA
*CR, f
5459 — A0158 In vivo confocal microstructural
analysis of corneal epithelial cell changes
related to daily wear use of silicone hydrogel
contact lenses. Jessica Lee 1 , X. Zhang 1 , C.
Marchetti 1 , Y. Jiang 2 , Y. Sun 1 , S. M. Debanne 2 , J.
Lemp 3 , B. Benetz 1 , P. Eric 1 , L. B. Szczotka-Flynn 1 .
1
Ophthalmology, University Hospitals Case
Medical Center, Cleveland, OH; 2 Epidemiology &
Biostatistics, University Hospitals Case Medical
Center, Cleveland, OH; 3 Alcon Laboratories, Fort
Worth, TX *CR, f
5463 — A0162 Optical Path Length
Quantification of Soft Contact Lens Parameter
Changes During Dehydration. Pete S. Kollbaum 1 ,
D. Iskander 2 , R. McGiffen 1 , M. E. Jansen 1 .
1
Optometry, Indiana University, Bloomington,
IN; 2 Institute of Biomedical Engineering
and Instrumentation, Wroclaw University of
Technology, Wroclaw, Poland *CR
5473 — A0172 Ocular Signs and Symptoms
in Contact Lens Wearers in a Controlled Low
Humidity Environmental Exposure Chamber
(LH-EEC), A Natural Provocation Research
Model. Piyush Patel 1 , F. Soong 1 , J. P. Varikooty 2 ,
N. J. Keir 2 , L. W. Jones 2 . 1 Inflamax Research,
Mississauga, ON, Canada; 2 CCLR, University of
Waterloo, Waterloo, ON, Canada *CR
Thursday Posters
8:30 am – 10:15 am
5460 — A0159 The relationship between clinical
grading and objective image analysis of Lid Wiper
Epitheliopathy. Jalaiah P. Varikooty 1 , B. J. Lay 3 ,
N. J. Keir 1 , H. Burdin 3 , L. W. Jones 1 , T. L. Simpson 2 ,
J. Lemp 4 . 1 CCLR, School of Optometry and Vision
Science, University of Waterloo, Waterloo, ON,
Canada; 2 School of Optometry and Vision Science,
University of Waterloo, Waterloo, ON, Canada;
3
ADCIS, Baltimore, MD; 4 Global Medical Affairs,
R&D, Alcon, Fort Worth, TX *CR, f
5461 — A0160 Corneal Stroma and Endothelial
Cell Changes in Contact Lens Wearers
Visualized with Confocal Microscopy. Christine
Marchetti 1 , J. Lee 1 , X. Zhang 1 , Y. Sun 1 , S. M.
Debanne 1 , Y. Jiang 1 , J. R. Kern 2 , B. Benetz 1 , E.
Pearlman 1 , L. B. Szczotka-Flynn 1 . 1 Ophthalmology,
University Hospitals Case Western Reserve,
Cleveland, OH; 2 Alcon Laboratories, Fort Worth,
TX *CR, f
5462 — A0161 The effect of recovery periods
on end of day comfort. Ulrike Stahl 1 , N. J. Keir 1 ,
J. P. Varikooty 1 , K. Nandakumar 1 , A. J. Keech 1 , A.
Landers 2 , L. W. Jones 1 . 1 School of Optometry and
Vision Science, Centre for Contact Lens Research,
Waterloo, ON, Canada; 2 Alcon Vision Care, Duluth,
GA *CR, f
5464 — A0163 A Novel Approach for Data
Collection Evaluating Doctor and Patient
Preferences for Wearing a Daily Disposable
Contact Lens for Astigmatism. W L. Ball. PDMA,
Johnson & Johnson, Jacksonville, FL *CR
5465 — A0164 Visual Correction for Irregular
Corneas with Scleral Lenses. Muriel Schornack,
C. B. Nau, J. Pyle, S. V. Patel. Ophthalmology,
Mayo Clinic, Rochester, MN
5466 — A0165 Visual Performance and
Residual Aberration in Keratoconus Subjects
Wearing Custom Scleral Contact Lenses. Jason
D. Marsack, C. Nguyen, D. E. Koenig, A. Ticak, J.
D. Elswick, R. A. Applegate. Optometry, University
of Houston, Houston, TX *CR
5467 — A0166 Direct comparison between in
situ versus extraction techniques for measuring
adsorbed proteins: application to lysozyme
deposited onto hydrogel contact lenses. Brad
Hall, C. Phan, L. N. Subbaraman, L. W. Jones, J.
A. Forrest. University of Waterloo, Waterloo, ON,
Canada *CR
5468 — A0167 PRG4 as a Natural Boundary
Lubricant for Commercial Silicone Hydrogel
Contact Lenses. Michael L. Samsom 1 , A. Chan 1 , L.
W. Jones 2 , T. A. Schmidt 1 . 1 Biomedical Engineering,
University of Calgary, Calgary, AB, Canada;
2
School of Optometry, University of Waterloo,
Waterloo, ON, Canada *CR
5469 — A0168 Decreased Clearance between
Scleral Contact Lens and Cornea after 2 Hours
of Lens Wear. Cherie B. Nau, M. Schornack.
Ophthalmology, Mayo Clinic, Rochester, MN
5470 — A0169 Multivariate Statistical Analysis
Examining and Modeling Drug Release from
Contact Lens Materials. Frances Lasowski, G.
Guidi, H. Sheardown. Chemical Engineering,
McMaster University, Hamilton, ON, Canada *CR
5471 — A0170 A study of the feasibility
of fitting custom designed contact lenses to
guinea pigs, guided by AS-OCT imaging and
corneal topography. Yue Liu 1 , Z. Chen 2 , C. F.
Wildsoet 1 . 1 VIsion Science, Univ of CA, Berkeley
Sch of Optometry, Berkeley, CA; 2 Department of
Ophthalmology & Vision Science, Eye & ENT
hospital,Fudan University, Shanghai, China *CR
5472 — A0171 Investigation of Latanoprost
Release from Contact Lens Materials Using
in vitro Cell Models. Saman Mohammadi 1 ,
L. W. Jones 2, 3 , M. Gorbet 1, 3 . 1 Systems Design
Engineering, University of Waterloo, Waterloo,
ON, Canada; 2 School of Optometry, University
of Waterloo, Waterloo, ON, Canada; 3 Centre for
Contact Lens Research, University of Waterloo,
Waterloo, ON, Canada *CR
5474 — A0173 Correction of infant aphakia
after cataract surgery with rigid gas-permeable
contact lenses. Anja K. Gruenert 1 , M. Klueppel 3 ,
J. Hausser 4 , T. Reinhard 2 , R. Sundmacher 1 ,
T. Guthoff 1 , T. A. Fuchsluger 1 , G. Geerling 1 .
1
Department of Ophthalmology, Heinrich-Heine-
University, Duesseldorf, Germany; 2 Department of
Ophthalmology, University of Freiburg Hospital,
Freiburg, Germany; 3 Practice, Moers, Germany;
4
Practice, Duesseldorf, Germany *CR
5475 — A0174 The evaluation of Lid Wiper
Epitheliopathy in contact lens wearers in a
Controlled Low Humidity Environmental
Exposure Chamber. Lyndon W. Jones 1 , J. P.
Varikooty 1 , N. J. Keir 1 , F. Soong 2 , P. Patel 2 . 1 CCLR-
School of Optometry, University of Waterloo,
Waterloo, ON, Canada; 2 Inflamax Research,
Mississauga, ON, Canada *CR
5476 — A0175 Determination of Oxygen
Permeability of Soft Contact Lenses Using
Polarographic Lens Stacking and Single-Lens
with Various Powers. X Michael Liu, G. L. Oltean.
Global R&D, Bausch & Lomb, Rochester, NY *CR
5477 — A0176 The Large-Scale
Epidemiological Study on the Prescription
of Contact Lenses in Japan -The Result from
Analyzing approximately 330,000 Eyes of
Japanese Subjects-. Eiichi Okada 1 , N. Mizuki 2 ,
T. Kawagoe 2 , M. Nagasaki 1 , N. Matsunaga 3 , M.
Yoshida 3 . 1 Okada Eye Clinic, Yokohama, Japan;
2
Department of Ophthalmology, Yokohama City
University, School of Medicine, Yokohama, Japan;
3
Department of Public Health, Kyorin University,
School of Medicine, Mitaka, Japan
5478 — A0177 Comparative study of refractive
change between glasses and contact lenses users
-5 years prospective study against approximately
273 thousand Japanese eyes-. Masao Yoshida 1 ,
N. Mizuki 2 , T. Kawagoe 2 , M. Nagasaki 3 , N.
Matsunaga 1 , E. Okada 3 . 1 Department of Public
Health, Kyorin University School of Medicine,
Mitaka, Japan; 2 Department of Ophthalmology,
Yokohama City University School of Medicine,
Yokohama, Japan; 3 Okada Eye Clinic, Yokohama,
Japan
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
350

Thursday – Posters – 5479 – 5498
5479 — A0178 Risk Factors for microbial
bioburden during daily wear of silicone
hydrogel contact lenses. Ying Jiang 1 , M. Jacobs 2 ,
S. Bajaksouzian 2 , A. Foster 2 , S. M. Debanne 1 , R.
Bielefeld 3 , M. Garvey 3 , S. Raghupathy Bsoptom 4 ,
J. R. Kern 5 , L. B. Szczotka-Flynn 4 . 1 Department
of Epidemiology & Biostatistics, Case Western
Reserve Rniversity, Cleveland, OH; 2 Department
of Pathology, Case Western Reserve University,
Cleveland, OH; 3 Division of Information
Technology Services, Case Western Reserve
University, Cleveland, OH; 4 Department of
Ophthalmology & Visual Sciences and University
Hospitals Eye Institute, University Hospitals
Case Medical Center, Cleveland, OH; 5 Alcon
Laboratories, Fort Worth, TX *CR, f
5480 — A0179 An Examination of the Effects
of Evaporation on Antimicrobial Efficacy of
Contact Lens Care Solutions. Nancy Brady, M.
Milenkovic, A. Lam. Corneal Microbiology, Abbott
Medical Optics, Santa Ana, CA *CR
5481 — A0180 Evaluation of an auto-refractor
for over-refraction with multifocal contact lenses
patients. Anna Giner 2 , M. Aldaba 2 , M. Arjona 1 , J.
Pujol 1 . 1 CD6 - Optica i optometria, Polithechnical
University of Catalonia, Terrassa, Spain; 2 CD6,
Polithechnical University of Catalonia, Terrassa,
Spain *CR
5482 — A0181 Evaluation of the effect of
soft contact lens edge shape on conjunctival
epithelium. Dorota H. Szczesna-Iskander 1 , D.
Iskander 2 . 1 Institute of Physics, Wroclaw University
of Technology, Wroclaw, Poland; 2 Institute of
Biomedical Engineering And Instrumentation,
Wroclaw University of Technology, Wroclaw,
Poland *CR
5483 — A0182 The Cause of Midday Visual
Fogging in Scleral Gas Permeable Lens Wearers.
Anna McKinney 1 , W. L. Miller 1 , N. E. Leach 1 , C.
Polizzi 1 , E. van der Worp 2 , J. P. Bergmanson 1 .
1
University of Houston College of Optometry,
Houston, TX; 2 Maastricht University, Maastricht,
Netherlands *CR
5484 — A0183 Designing Multifocal Contact
Lenses using a Novel Through-Focus Image
Quality Metric Highly Correlated with Clinical
Visual Acuity. Nishant Mohan, A. C. Kingston, I.
G. Cox. Bausch and Lomb, Rochester, NY *CR
5485 — A0184 Prosthetic Replacement of the
Ocular Surface Ecosystem (PROSE) Treatment:
A Partner Clinic Experience. Kira L. Segal 1 ,
M. N. Lee 2 , K. O. Chapman 2 , M. Rosenblatt 2 , K.
C. Sippel 2 , C. E. Starr 2 , J. Ciralsky 2 . 1 Medicine,
Memorial Sloan Kettering Cancer Center, New
York, NY; 2 Ophthalmology, NewYork-Presbyterian,
New York, NY
5486 — A0185 Effect of Static and Non-
Static in-vitro Techniques on Lipid Penetration
Into SiHy Contact Lenses. Jean T. Jacob 1, 2 , R.
Frederick 1, 2 , C. Tucker 1, 3 , L. Love 1, 4 . 1 Department
of Ophthalmology, LSU Health Sciences Center,
New Orleans, LA; 2 Biomedical Engineering, Tulane
University, New Orleans, LA; 3 University of New
Orleans, New Orleans, LA; 4 Xavier University,
New Orleans, LA *CR
5487 — A0186 Visual Performance and Optical
Quality with New Silicone-hydrogel Soft Contact
Lenses for Keratoconus. Asaki Suzaki 1 , N. Maeda 2 ,
M. Fuchihata 2 , S. Koh 2 , K. Nishida 2 , T. Fujikado 1 .
1
Applied Visual Science, Osaka University Graduate
School of Medicine, Suita, Japan; 2 Ophthalmology,
Osaka University Graduate School of Medicine,
Suita, Japan *CR
5488 — A0187 In-Vitro Spoilation of SiHy Soft
Contact Lenses using LAESI-MS and FCSLM.
Trust T. Razunguzwa 1 , H. Goodman 1 , C. Peng 2 ,
N. Fajardo 2 , C. J. Radke 2 . 1 Protea Biosciences
Group Inc., Morgantown, WV; 2 Chemical and
Biomolecular Engineering, University of California,
Berkeley, CA *CR
5489 — A0188 Tear Film Proteins Strongly-
Adherent to a Non-Ionic Silicone Hydrogel
Contact Lens Across the Wear Cycle. Michael S.
Foster, A. Landers, M. M. Gabriel, J. D. Lane, W. L.
Nash. Vision Care, Alcon, Duluth, GA *CR
5490 — A0189 Objective Visual Performance of
Low-add Multifocal Contact Lenses. Balamurali
Vasudevan, S. N. Gaib. Optometry, Midwestern
University, Glendale, AZ *CR
Exhibit Hall B0001-B0052
Thursday, May 09, 2013 8:30 AM-10:15 AM
Multidisciplinary Ophthalmic Imaging
507 Image Processing and
Segmentation Algorithms
Moderator: Delia DeBuc
5491 — B0001 Using Asymmetry Analysis to
Reduce Normal Variability of Spectral Domain
Optical Coherence Tomography (SD-OCT)
Macular Thickness. Muhammed S. Alluwimi, W.
H. Swanson, V. Malinovsky. School of Optometry,
Indiana University Bloomington, Bloomington, IN
5492 — B0002 Comparison and normalization
of retinal reflectivity profiles between spectraldomain
optical coherence tomography devices.
Zhihong Hu, M. Nittala, S. Sadda. Retina, Doheny
Eye Institute, Arcadia, CA *CR
5493 — B0003 Retinal Central Reflex
Quantification: A New Approach for Central
Reflex Grading and Severity Measurement.
Alauddin Bhuiyan 1 , E. L. Lamoureux 2 , J. Wang 3 , C.
Y. Cheung 2 , K. Yogesan 1 , T. Y. Wong 2 . 1 Australian
E-Health Research Centre, Commonwealth
Scientific &Industrial Research Organization,
Floreat, WA, Australia; 2 Singapore Eye Research
Institute, Singapore, Singapore; 3 University of
Sydney, Sydney, NSW, Australia *CR
5494 — B0004 An automated system for the
detection of AMD-related drusen in retinal
fundus images. Damon Wong 1 , J. Liu 1 , F. Yin 1 , J.
Zhang 2 , N. Tan 1 , M. Bhargava 3 , G. C. Cheung 3 ,
T. Y. Wong 3 . 1 Insittute for Infocomm Research,
Singapore, Singapore; 2 Nanyang Technological
University, Singapore, Singapore; 3 Singapore Eye
Research Insttute, Singapore, Singapore *CR
5495 — B0005 Automated quantification of
drusen and choroid using clinical SD-OCT. Li
Zhang 1 , G. H. Buitendijk 3, 4 , K. Lee 1 , A. Wahle 1 ,
M. Sonka 1, 2 , C. C. Klaver 3, 4 , M. D. Abramoff 2, 5 .
1
Electrical And Computer Engineering, University
of Iowa, Iowa City, IA; 2 Ophthalmology and
Visual Sciences, University of Iowa, Iowa City, IA;
3
Department of Ophthalmology, Erasmus Medical
Center, Rotterdam, Netherlands; 4 Department of
Epidemiology, Erasmus Medical Center, Rotterdam,
Netherlands; 5 Veterans Affairs, Iowa City VA
Medical Center, Iowa City, IA *CR
5496 — B0006 Automatic Drusen
Quantification and Risk Assessment of Agerelated
Macular Degeneration on Color
Fundus Images. Mark J J P van Grinsven 1 , Y. T.
Lechanteur 2 , J. P. van de Ven 2 , B. van Ginneken 1 , C.
B. Hoyng 2 , T. Theelen 2 , C. I. Sanchez 1 . 1 Radiology,
Radboud University Nijmegen Medical Centre,
Nijmegen, Netherlands; 2 Ophthalmology, Radboud
University Nijmegen Medical Centre, Nijmegen,
Netherlands *CR
5497 — B0007 Tissue, microscopy, and
computational techniques for mapping human
retinal pigment epithelium cell number and
autofluorescence. Thomas Ach 1 , J. D. Messinger 1 ,
M. J. Bentley 2 , F. C. Delori 3 , K. R. Sloan 2 , C. A.
Curcio 1 . 1 Dept of Ophthalmology, University
of Alabama at Birmingham, Birmingham, AL;
2
Computer and Information Science, University
of Alabama at Birmingham, Birmingham, AL;
3
Ophthalmology, Schepens Eye Research Institute,
Boston, MA
5498 — B0008 A Multimodal Machine-
Learning-Based Approach for Segmenting
the Optic Disc and Cup in Fundus and SD-
OCT Images. Mohammad Saleh Miri 1, 2 , M. D.
Abramoff 2 3 , K. Lee 1 , M. Niemeijer 1 , A. Wahle 1 , Y. H.
Kwon 3 , M. K. Garvin 2, 1 . 1 Electrical and Computer
Engineering, The University of Iowa, Iowa City, IA;
2
Center for the Prevention and Treatment of Visual
Loss, Iowa City VA Health Care System, Iowa City,
IA; 3 The Department of Ophthalmology and Visual
Sciences, The University of Iowa, Iowa City, IA
*CR
Thursday Posters
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
351

5499 – 5517 – Thursday – Posters
Thursday Posters
8:30 am – 10:15 am
5499 — B0009 Automated segmentation of
the in-vivo lamina cribrosa (LC) imaged using
3D optical coherence tomography (OCT). Bo
Wang 1, 2 , Z. Nadler 1 , J. E. Nevins 1 , R. A. Bilonick 1, 3 ,
H. Ishikawa 1, 4 , L. Kagemann 1, 4 , I. Grulkowski 5 , J.
J. Liu 5 , J. G. Fujimoto 5 , J. S. Schuman 1, 4 . 1 UPMC
Eye Center, Eye and Ear Institute, Ophthalmology
and Visual Science Research Center, Department
of Ophthalmology, University of Pittsburgh,
Pittsburgh, PA; 2 Medical Scientist Training
Program, University of Pittsburgh, Pittsburgh, PA;
3
Department of Biostatistics, Graduate School of
Public Health, University of Pittsburgh, Pittsburgh,
PA; 4 Department of Bioengineering, University
of Pittsburgh, Pittsburgh, PA; 5 Department of
Electrical Engineering and Computer Science,
Massachusetts Institute of Technology, Cambridge,
MA *CR
5500 — B0010 Automated Choroidal
Segmentation in 1µm Swept Source Deep
Range Imaging OCT. Qi Yang 1 , C. A. Reisman 1 ,
R. Ramachandran 2 , A. S. Raza 2 , D. C. Hood 2, 3 ,
K. Chan 1 . 1 Topcon Adv Biomed Imaging
Lab, Topcon Medical Systems, Oakland, NJ;
2
Psychology, Columbia University, New York, NY;
3
Ophthalmology, Columbia University, New York,
NY *CR
5501 — B0011 SD OCT Analysis of Retinal
Zones Identified as Abnormal with Ultra-
Widefield Autofluorescence. Jerome Sherman 1, 2 ,
D. Epshtein 1 , S. Nath 3, 4 , S. Slotnick 1, 2 . 1 Clinical
Sciences, SUNY College of Optometry, New York,
NY; 2 SUNY Eye Institute, State University of New
York, NY, NY; 3 Eye Institute and Laser Center, New
York, NY; 4 NY Eye and Ear Infirmary, New York,
NY *CR
5502 — B0012 Validation of the Precision of
a Novel Representation of Images Obtained by
the Optos P200Tx Ultra Wide-Field Imaging
System. Natasha Maqsood 1 , R. Sophie 1 , J. van
Hemert 2 , D. Swan 2 , M. Verhoek 2 , M. G. Bittencourt 1 ,
D. A. Ferraz 1 , H. Jang 1 , Y. J. Sepah 1 , Q. Nguyen 1 .
1
Retinal Imaging Research and Reading Centre,
Johns Hopkins University, Baltimore, MD; 2 Optos,
Dunfermline, United Kingdom *CR
5503 — B0013 Total Retinal Thickness Using
Iowa Reference Algorithm: Measurement
Reproducibility in 5 SD-OCT Scanners. Adnan
Rashid 1 , U. Schmidt-Erfurth 4, 5 , B. S. Gerendas 5 ,
S. M. Waldstein 6 , H. Bogunovic 1 , A. Wahle 1 , C.
Simader 6 , K. Lee 1 , M. Sonka 1, 2 , M. D. Abramoff 2, 3 .
1
Electrical and Computer Engineering, The
University of Iowa, Iowa City, IA; 2 Ophthalmology
and Visual Sciences, The university of Iowa,
Iowa City, IA; 3 Veterans Affairs, Medical Center,
Iowa City, IA; 4 Department of Ophthalmology,
Medical University of Vienna, Vienna, Austria;
5
Ophthalmology & Optometry, Med Univ Vienna,
Vienna Gen Hosp, Vienna, Austria; 6 Vienna Reading
Center, Department of Ophthalmology, University
of Vienna, Vienna, Austria *CR
5504 — B0014 Fully Automatic Risk
Assessment Of Diabetic Retinopathy In Digital
Fundus Images. E Simon Barriga 1, 2 , C. Agurto 1 ,
H. Yu 1 , V. Joshi 1 , C. Carranza 2 , J. Wigdahl 1 , S. C.
Nemeth 1 , G. Zamora 1 , W. C. Bauman 3 , P. Soliz 1, 4 .
1
VisionQuest Biomedical LLC, Albuquerque, NM;
2
Electrical and Computer Engineering, University of
New Mexico, Albuquerque, NM; 3 Retina Institute
of South Texas, San Antonio, TX; 4 Ophthalmology
and Visual Sciences, University of Iowa, Iowa City,
IA *CR
5505 — B0015 Correlation between Fluorescein
Leakage Maps Generated by Automated
Leakage Quantification of Fluorescein
Angiogram and Retinal Thickness Maps Created
by OCT in Eyes with Neovascular AMD.
Mostafa Hanout 1 , E. Magdy 2 , O. O. Agbedia 1 , M.
A. Ibrahim 1 , M. G. Bittencourt 1 , M. A. sadiq 1 , D.
Ferraz 1 , A. Moradi 1 , A. S. Fahmy 2, 3 , Q. Nguyen 1 .
1
Retinal Imaging Research and Reading Center,
Wilmer Eye Institute, Johns Hopkins University,
Baltimore, MD; 2 Center for Informatics Science,
Nile University, Cairo, Egypt; 3 Systems of
Biomedical Engineering Department, Cairo
University, Cairo, Egypt *CR
5506 — B0016 Semi-automated Contour
Analysis of SD-OCT images after Epiretinal
Membrane Peeling using either air tamponade
or balanced salt solution. Focke Ziemssen, M.
Leitritz, D. Zobor, M. Voelker, K. Bartz-Schmidt,
F. Gelisken. Center of Ophthalmology, University
Tuebingen, Tuebingen, Germany *CR
5507 — B0017 A Fully Automatic Framework
for Segmentation and Localization of Retinal
Structures in Fundus Images. Attila Budai 1, 2 ,
K. Mogalle 1 , K. Laurik 4 , J. M. Hornegger 1, 2 , G.
Michelson 3 . 1 Pattern Recognition Lab, University
of Erlangen-Nuremberg, Erlangen, Germany;
2
Erlangen Graduate School in Advanced
Optical Technologies, Erlangen, Germany;
3
Interdisciplinary Center of Ophthalmic Preventive
Medicine and Imaging (IZPI), Erlangen, Germany;
4
Department of Ophthalmology, Semmelweis
University, Budapest, Hungary *CR
5508 — B0018 Reliability of automatic
measurements for thickness profiles of intraretinal
layers using ultra-high resolution optical
coherence tomography. Xinting Liu, M. Shen, S.
Huang, D. Zhu, L. Leng, F. Lu. Wenzhou Medical
College, Wen Zhou, China
5509 — B0019 Automatic Segmentation of
OCT Datasets Using Superpixels-Classification.
Pascal A. Dufour 1, 2 , H. Abdillahi 3, 2 , L. Ceklic 3, 2 , U.
E. Wolf-Schnurrbusch 3, 2 , S. Wolf 2 , J. H. Kowal 1, 2 .
1
Ophthalmic Technologies ARTORG Center,
University of Bern, Bern, Switzerland; 2 Department
of Ophthalmology, University Hospital Bern, Bern,
Switzerland; 3 Bern Photographic Reading Center,
University Hospital Bern, Bern, Switzerland *CR
5510 — B0020 Automated choroidal
neovascularization associated abnormality
detection and quantitative analysis from clinical
SD-OCT. Xiayu Xu 1 , L. Zhang 1 , K. Lee 1 , A.
Wahle 1 , X. Chen 3 , X. Wu 1 , M. D. Abramoff 1, 2 , M.
Sonka 1 . 1 Department of Electrical and Computer
Engineering, University of Iowa, Iowa City, IA;
2
Ophthalmology & Visual Sciences, University of
Iowa, Iowa City, IA; 3 School of Electronics and
Information Engineering, Soochow University,
Soochow, China *CR
5511 — B0021 A new computer-assisted
image processing technique for quantitative
analysis of the impact of pterygia on refractive
indices and ocular higher-order aberrations.
Koray Gumus 1 , A. Guven 2 , M. Guler 2 , M. Gerdan 1 .
1
Department of Ophthalmology, Erciyes University
School of Medicine, Kayseri, Turkey; 2 Biomedical
Engineering Faculty, Erciyes University, Kayseri,
Turkey
5512 — B0022 Choroidal Thickness in Age-
Related Macular Degeneration as measured by
Semi-Automated Segmentation of the Choroid
in Enhanced-Depth Imaging Optical Coherence
Tomography. Glenn Yiu 1 , S. Fekrat 1 , N. Sarin 1 ,
S. J. Chiu 2 , S. Stinnett 1 , S. Farsiu 1, 2 , C. A. Toth 1, 2 .
1
Ophthalmology, Duke University Medical Center,
Durham, NC; 2 Biomedical Engineering, Duke
University, Durham, NC *CR
5513 — B0023 Clinical Utility of Thresholding
Segmentation in Ultra-Widefield (Optos ® )
Fundus Autofluorescence Images. Sarah
MacIver 1 , J. Sherman 2, 3 , N. Hutchings 1 . 1 Univ of
Waterloo Sch of Optom, Waterloo, ON, Canada;
2
Clinical Sciences, SUNY State College of
Optometry, New York, NY; 3 SUNY Eye Institute,
State University of New York, New York, NY *CR
5514 — B0024 Reliability of Automated
Leakage Quantification of Fluorescein
Angiography in Eyes with Diabetic Macular
Edema. Owhofasa O. Agbedia 1 , E. Magdy 2 ,
M. A. Ibrahim 1 , Y. J. Sepah 1 , R. Sophie 1 , M. G.
Bittencourt 1 , M. Hanout 1 , D. V. Do 1 , A. Fahmy 2 , Q.
Nguyen 1 . 1 Retinal Imaging Research and Reading
Center, Wilmer Eye Institute, Johns Hopkins
University, Baltimore, MD; 2 Center for Informatics
Science, Nile University, Giza, Egypt *CR
5515 — B0025 Evaluation of a New
Registration Algorithm Using iVue SD-OCT. Jing
Cui, B. K. Jang. Optovue, Inc, Fremont, CA *CR
5516 — B0026 Digital Image Grading Tool
for Uveitis Clinical Trials. Brian Madow.
Ophthalmology, University of South Florida,
Tampa, FL
5517 — B0027 Automated correction of 3D
acquisitions using a high frequency rotative
ultrasound probe. Charly Maindron 1, 2 , M. Le
Loir 4 1 , B. Cochener 4, 1 , M. Lamard 3, 1 . 1 LaTIM
- UMR 1101, Brest, France; 2 Quantel Medical,
Cournon d’Auvergne, France; 3 Université de
Bretagne Occidentale, Brest, France; 4 CHU Brest,
Service d’ophtalmologie, Brest, France *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
352

Thursday – Posters – 5518 – 5538
5518 — B0028 3D Motion Correction and
Signal Improvement in High speed Polarization
Sensitive Optical Coherence Tomography. Martin
F. Kraus 1, 2 , A. Dhalla 2 , J. J. Liu 2 , K. J. Mohler 2 , C.
D. Lu 2 , B. Potsaid 2 , J. M. Hornegger 1 , D. Huang 3 ,
J. G. Fujimoto 2 . 1 Pattern Recognition Lab and
SAOT, University Erlangen Nuremberg, Erlangen,
Germany; 2 Dept. of Electrical Engineering and
Computer Science and Research Laboratory of
Electronics, Massachusetts Institute of Technology,
Cambridge, MA; 3 Casey Eye Institute, Oregon
Health & Science University, Portland, OR *CR
5519 — B0029 Retinal layer segmentation
in a pediatric normal group. Stefan Pelz, H.
Wildberger, C. Gerth-Kahlert. Ophthalmology,
University of Zurich, Zurich, Switzerland
5520 — B0030 Detection of Neovascularization
in Digital Fundus Images Using a Multiscale
Analysis Approach. Carla Agurto Rios 1 , H.
Yu 1 , J. Wigdahl 1 , V. Murray 2 , E. Barriga 1 , W. C.
Bauman 3 , P. Soliz 1, 4 . 1 Research & Development,
VisionQuest Biomedical LLC, Albuquerque, NM;
2
Universidad de Ingenieria & Tecnologia, Lima,
Peru; 3 Retina Institute of South Texas, San Antonio,
TX; 4 Department of Ophthalmology and Visual
Sciences, University of Iowa, Iowa city, IA *CR
5521 — B0031 Triangle mesh segmentation
and reconstruction of HD 3D OCT data sets for
augmented reality simulation purposes. Carl G.
Glittenberg, S. Binder. Dept of Ophthalmology,
Rudolph Foundation Hospital, Vienna, Austria
5522 — B0032 Multispectral Retinal Image
Analysis (MRIA) for the Quantification of
Macular Pigment. Antonio Calcagni 1, 2 , I. Styles 2 ,
A. D. Palmer 2 , Y. Shen 2 , H. Bartlett 1 , F. Eperjesi 1 ,
J. M. Gibson 1 , E. Claridge 2 . 1 School of Life and
Health Sciences, Aston University, Birmingham,
United Kingdom; 2 School of Computer Science,
University of Birmingham, Birmingham, United
Kingdom
5523 — B0033 Automatic Segmentation of
Photoreceptors in AOSLO Images Using Graph
Theory and Dynamic Programming. Stephanie J.
Chiu 1 , A. M. Dubis 2 , A. Dubra 3, 4 , J. Carroll 3, 4 , J. A.
Izatt 1, 2 , S. Farsiu 2, 1 . 1 Biomedical Engineering, Duke
University, Durham, NC; 2 Ophthalmology, Duke
University, Durham, NC; 3 Ophthalmology, Medical
College of Wisconsin, Milwaukee, WI; 4 Biophysics,
Medical College of Wisconsin, Milwaukee, WI *CR
5524 — B0034 Texture-Based Eye Motion
Correction for 3D OCT Imaging. Omaima
M. Nomir, H. Jiang, J. Wang, D. DeBuc.
Ophthalmology, Univ of Miami School of Med,
Miami, FL *CR
5525 — B0035 Automated Detection of Hyperreflective
Structures Associated with Diabetic
Retinopathy using Spectral Domain Optical
Coherence Tomography (SD-OCT). David W.
Stein 1 , N. K. Waheed 2 , M. Adhi 2 , S. K. Semy 1 , J.
S. Duker 2 , W. Kuklinski 1 . 1 MITRE, Bedford, MA;
2
Ophthalmology, New England Eye Center, Boston,
MA *CR
5526 — B0036 Spectral Domain OCT
individual retinal layering of diabetics with and
without retinopathy. Silvia Bini 1 , S. Vujosevic 1 ,
M. Berton 1 , E. Pilotto 1 , E. Midena 1, 2 . 1 Department
of Ophthalmology, University of Padova, Padova,
Italy; 2 G.B. Bietti Foundation, IRCCS, Roma, Italy
5527 — B0037 Large Retinal Hemorrhage
Detector for Automated Diabetic Retinopathy
Screening System. Li Tang 1, 2 , M. Niemeijer 3 , M. D.
Abramoff 1, 2 . 1 Ophthal & Visual Sciences, University
of Iowa, Iowa City, IA; 2 Department of Veterans
Affairs, Center of Excellence for Prevention of
Visual Loss and Blindness, Iowa City, IA; 3 IDx
LLC, Iowa City, IA *CR
5528 — B0038 Image Registration for Motion
Artifact Removal in Retinal Vascular Imaging
Using Speckle Variance Fourier Domain Optical
Coherence Tomography. Hansford C. Hendargo 1 ,
R. Estrada 2 , S. J. Chiu 1 , C. Tomasi 2 , S. Farsiu 3,
1
, J. A. Izatt 1, 3 . 1 Biomedical Engineering, Duke
University, Durham, NC; 2 Computer Science, Duke
University, Durham, NC; 3 Ophthalmology, Duke
University, Durham, NC *CR
5529 — B0039 A computer-aided manual
segmentation method for SD-OCT images yields
increased inter-grader reproducibility. Yijun
Huang 1 , J. W. Pak 1 , S. Luo 1 , J. White 1 , X. Zhang 2 ,
R. P. Danis 1 . 1 Ophthal & Vis Sciences-FUNDUS,
University of Wisconsin-Madison, Madison, WI;
2
Department of Psychology, Columbia University,
New York, NY *CR
5530 — B0040 Automatic Segmentation of
Corneal Lamellar Graft Surfaces from Low-
Contrast Optical Coherence Tomography
Images. Alec V. Arshavsky 1, 3 , F. LaRocca 2 , J.
A. Izatt 2, 3 , A. N. Kuo 3 , S. Farsiu 2, 3 . 1 East Chapel
Hill High School, Chapel Hill, NC; 2 Biomedical
Engineering, Duke University, Durham, NC;
3
Ophthalmology, Duke University, Durham, NC
*CR
5531 — B0041 Automated Segmentation of
Sub-Retinal Layers in Age-related Macular
Degeneration. Katrina A. Mears 1 , L. Zhang 2 ,
K. Lee 2 , X. Xu 2 , M. Sonka 1, 2 , M. D. Abramoff 1, 2 .
1
Department of Ophthalmnology and Visual
Sciences, University of Iowa Hospitals and
Clinids, Iowa city, IA; 2 Electrical and Computer
Engineering, University Of Iowa, Iowa city, IA *CR
5532 — B0042 Methods for manual and
automated detection of the four outer retinal
hyper-reflective bands in optical coherence
tomography scans. Douglas Ross 1, 2 , M. Clark 4 ,
P. Godara 6, 3 , G. McGwin 3 , R. F. Spaide 5 , K. R.
Sloan 2 , C. A. Curcio 3 . 1 Mechanical Engineering,
UAB, Birmingham, AL; 2 Computer and Information
Sciences, UAB, Birmingham, AL; 3 Ophthalmology,
UAB, Birmingham, AL; 4 UAB, Birmingham,
AL; 5 Vitreous Retina Macula Consultants NY,
New York, NY; 6 Ophthalmology, Eye Institute,
Birmingham, AL *CR
5533 — B0043 Global and Regional
Intrasession Test-Retest Variability of Macular
Thickness Measurements with Spectral-domain
Optical Coherence Tomography with and
without Tracking. Elaine Thung, S. Knipping,
J. Caprioli, K. Nouri-Mahdavi. Ophthalmology,
UCLA Jules Stein Eye Institute, Los Angeles, CA
*CR
5534 — B0044 Novel method for registration
and statistical analysis of volumetric retinal OCT
data using surface currents. Evgeniy Lebed 1 ,
S. Lee 1 , S. X. Han 1 , P. Mackenzie 3 , A. Trouve 2 ,
M. V. Sarunic 1 , M. Beg 1 . 1 Engineering Science,
Simon Fraser University, Burnaby, BC, Canada;
2
Centre de Mathématiques et Leurs Applications,
Ecole Normale Supérieure, Cachan, France;
3
Ophthalmology and Visual Sciences, University of
British Columbia, Vancouver, BC, Canada
5535 — B0045 Signal Normalization Between
Non-Averaged and Frame-Averaged Optical
Coherence Tomography (OCT) Images.
Chieh-Li Chen 1, 2 , H. Ishikawa 1, 2 , G. Wollstein 1 ,
R. A. Bilonick 1, 3 , I. A. Sigal 1, 2 , L. Kagemann 1, 2 ,
J. G. Fujimoto 4 , J. S. Schuman 1, 2 . 1 UPMC Eye
Center, Eye and Ear Institute, Ophthalmology and
Visual Science Research Center, Department of
Ophthalmology, University of Pittsburgh School
of Medicine, Pittsburgh, PA; 2 Department of
Bioengineering, Swanson School of Engineering,
University of Pittsburgh, Pittsburgh, PA;
3
Department of Biostatistics, Graduate School of
Public Health, University of Pittsburgh, Pittsburgh,
PA; 4 Department of Electrical Engineering and
Computer Science, Massachusetts Institute of
Technology, Cambridge, MA *CR
5536 — B0046 Use of super-resolution image
reconstruction techniques in optical coherence
tomography. David Alonso-Caneiro, S. A. Read,
M. J. Collins. Contact Lens and Visual Optics Lab,
Queensland University of Technology, Brisbane,
QLD, Australia
5537 — B0047 Image Fusion System to
Combine Fluorescence Lifetime Imaging of the
Retina with Optical Coherence Tomography
Imaging. Jens H. Kowal 1, 2 , P. A. Dufour 1, 2 , T.
Rudolph 1, 2 , S. Wolf 2 . 1 Ophthalmic Technologies
ARTORG Center, University of Bern, Bern,
Switzerland; 2 Department of Ophthalmology,
University of Bern, Bern, Switzerland *CR
5538 — B0048 Volumes of retinal layers
measured by spectral-domain optical coherence
tomography and public domain software
ImageJ. Albert Caramoy 1 , K. Droge 1 , B. Kirchhof 1 ,
C. B. Hoyng 2 , S. Fauser 1 . 1 Department of
Ophthalmology, University of Cologne, Cologne,
Germany; 2 Department of Ophthalmology, Radboud
University Nijmegen Medical Centre, Nijmegen,
Netherlands *CR
Thursday Posters
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
353

5539 – 5554 – Thursday – Posters
Thursday Posters
8:30 am – 10:15 am
5539 — B0049 Fully-automated multimodal
co-registration of optical coherence tomography
to colour fundus photography and fluorescein
angiography. Pedro Guimaraes 1 , P. Rodrigues 2 ,
C. F. Lobo 2 , P. Serranho 3, 1 , R. Bernardes 1, 2 . 1 IBILI
- Faculty of Medicine, University of Coimbra,
Coimbra, Portugal; 2 CNTM/AIBILI - Association
for Innovation and Biomedical Research on Light
and Image, Coimbra, Portugal; 3 Mathematics
Section, Department of Science and Technology,
Open University, Lisbon, Portugal f
5540 — B0050 Automatic Segmentations
of Intra-retinal Layers and Optic Nerve
Head in UHR-OCT Images Using Dynamic
Programming. Shenghai Huang, M. Shen, X.
Liu, L. Leng, F. Lu. Wenzhou Medical College,
Wenzhou, China
5541 — B0051 Virtual Frame Averaging
- A Novel Image Enhancement Method for
Three-Dimensional (3D) Optical Coherence
Tomography (OCT) Images. Hiroshi Ishikawa 1, 2 ,
C. Chen 1, 2 , G. Wollstein 1 , L. Kagemann 1, 2 , I. A.
Sigal 1, 2 , R. A. Bilonick 1, 3 , J. G. Fujimoto 4 , J. S.
Schuman 1, 2 . 1 UPMC Eye Center, Eye and Ear
Institute, Ophthalmology and Visual Science
Research Center, Department of Ophthalmology,
University of Pittsburgh School of Medicine,
Pittsburgh, PA; 2 Department of Bioengineering,
Swanson School of Engineering, University
of Pittsburgh, Pittsburgh, PA; 3 Department
of Biostatistics, Graduate School of Public
Health, University of Pittsburgh, Pittsburgh,
PA; 4 Department of Electrical Engineering and
Computer Science, Massachusetts Institute of
Technology, Cambridge, MA *CR
5542 — B0052 DTI Fiber tracking Analysis
of the visual input to the pallidum in humans:
preliminary results. Hachemi Nezzar 1, 2 , L.
J. Sakka 3, 2 , J. Coste 3, 2 , J. Gabrillargues 4, 2 ,
F. Chiambaretta 1 , J. Lemaire 3, 2 . 1 Dept of
Ophthalmology, CHU Clermont Ferrand,
Clermont-Ferrand, France; 2 IGCNC EA 3295,
Université d’Auvergne, Clermont Ferrand, France;
3
Dept of Neurosurgery, CHU Clermont Ferrand,
Clermont Ferrand, France; 4 Dept of Radiology,
neuroradiology, CHU Clermont Ferrand, Clermont
Ferrand, France
Exhibit Hall B0053-B0064
Thursday, May 09, 2013 8:30 AM-10:15 AM
Visual Psychophysics / Physiological Optics
508 Improving Imaging and
Ophthalmic Instrumentation
Moderator: Zoran Popovic
5543 — B0053 Stabilized cone imaging with
adaptive optics optical coherence tomography.
Omer P. Kocaoglu 1 , R. D. Ferguson 2 , Z. Liu 1 ,
R. S. Jonnal 1 , Q. Wang 1 , D. X. Hammer 3 , D. T.
Miller 1 . 1 School of Optometry, Indiana University,
Bloomington, IN; 2 Physical Sciences Inc.,
Andover, MA; 3 Office of Science and Engineering
Laboratories, Center for Devices and Radiological
Health, Food and Drug Administration, Silver
Spring, MD *CR
5544 — B0054 In vivo Imaging of the Human
Retinal Pigment Epithelium Cell Mosaic
using Short-wavelength Autofluorescence and
achromatizing lenses. Alfredo Dubra 1, 2 , D. H.
Scoles 3 , Y. N. Sulai 4 . 1 Ophthalmology, Medical
College of Wisconsin, Milwaukee, WI; 2 Biophysics,
Medical College of Wisconsin, Milwaukee, WI;
3
Biomedical Engineering, University of Rochester,
Rochester, NY; 4 The Institute of Optics, University
of Rochester, Rochester, NY *CR
5545 — B0055 A novel compact optical
instrument for the clinical measurement of
intraocular light scattering. Onurcan Sahin 1 ,
H. S. Ginis 2, 1 , G. M. Perez 3 , J. M. Bueno 2 , P.
Artal 2 . 1 Institute of Vision & Optics, University of
Crete, Heraklion, Greece; 2 Laboratorio de Optica,
Universidad de Murcia, Murcia, Spain; 3 Voptica SL,
Murcia, Spain *CR
5546 — B0056 The Effect of AOSLO Image
Distortion on Metrics of Mosaic Geometry.
Robert F. Cooper 1 , Z. Harvey 2 , M. Dubow 3, 4 , Y.
N. Sulai 5 , A. Pinhas 3, 4 , D. H. Scoles 6 , N. Shah 3 , R.
B. Rosen 3 , A. Dubra 2, 7 , J. Carroll 2, 8 . 1 Biomedical
Engineering, Marquette University, Milwaukee, WI;
2
Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI; 3 New York Eye and Ear Infirmary,
New York, NY; 4 Mount Sinai School of Medicine,
Mount Sinai Hospital, New York, NY; 5 The Institute
of Optics, University of Rochester, Rochester, NY;
6
Biomedical Engineering, University of Rochester,
Rochester, NY; 7 Biophysics, Medical College of
Wisconsin, Milwaukee, WI; 8 Cell Biology, Medical
College of Wisconsin, Milwaukee, WI *CR
5547 — B0057 Photoreceptor imaging with
in-the-plane adaptive optics optical coherence
tomography using toroidal mirrors. Zhuolin Liu,
O. P. Kocaoglu, Q. Wang, D. T. Miller. School of
Optometry, Indiana University, Bloomington, IN
*CR
5548 — B0058 Evaluation of a Dual-Conjugate
Adaptive Optics Clinical Prototype for
Retinal Imaging. Zoran Popovic 1 , J. Thaung 1 ,
B. Svensson 2 , M. Owner-Petersen 1 . 1 Department
of Ophthalmology, University of Gothenburg,
Mölndal, Sweden; 2 Exomed AB, Sollentuna,
Sweden *CR
5549 — B0059 AO-OCT Retinal Imaging with
163-Segment Deformable Mirror. Susanna C.
Finn 1 , C. Greiner 1 , N. Doble 1 , R. J. Zawadzki 2 ,
J. S. Werner 2 , S. S. Choi 1 . 1 Vision Science, New
England College of Optometry, Boston, MA;
2
Ophthalmology & Vision Science, University of
California Davis, Davis, CA *CR
5550 — B0060 Use of multiple metrics to
describe the parafoveal cone mosaic. Marco
Lombardo 1 , S. Serrao 1 , P. Ducoli 1 , G. Lombardo 2,
3
. 1 Fondazione GB Bietti IRCCS, Rome, Italy;
2
CNR-IPCF Unit of Support Cosenza, Rende, Italy;
3
Vision Engineering, Rome, Italy
5551 — B0061 Improved Sensitivity of
Automated Cone Identification in Images
of Adaptive Optics Scanning Laser
Ophthalmoscope (AOSLO). Keiko Yonezawa 1 ,
H. Sonobe 1 , A. Uji 2 , S. Ooto 2 , M. Hangai 2 , N.
Yoshimura 2 . 1 Medical Imaging Project, Canon Inc.,
Tokyo, Japan; 2 Ophthalmology, Kyoto University
Graduate School of Medicine, Kyoto, Japan *CR
5552 — B0062 Photoreceptors, Retinal Nerve
Fibers and Retinal Blood Flow Observation by
AOSLO Applied to Wide Diopter Range. Takashi
Yuasa 1 , F. Hirose 1 , K. Saito 1 , K. Matsumoto 1 ,
H. Sonobe 1 , A. Uji 2 , S. Ooto 2 , M. Hangai 2 , N.
Yoshimura 2 . 1 Medical Imaging Project, Canon Inc.,
Ohta-ku, Japan; 2 Ophthalmology, Kyoto University
Graduate School of Medicine, Kyoto City, Japan
*CR
5553 — B0063 Compact multimodal adaptive
optics imager (MAOI). R. D. Ferguson, M. Mujat,
A. Patel, N. Iftimia. Biomedical Imaging Group,
Physical Sciences Inc, Andover, MA *CR
5554 — B0064 Use of variable Field Size
in AOSLO retinal imaging to improve postprocessing.
Ting Luo, G. Huang, T. Y. Chui, S. A.
Burns. School of Optometry, Indiana University
Blooomington, Bloomington, IN
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
354

Thursday – Posters – 5555 – 5575
Exhibit Hall B0078-B0103
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retinal Cell Biology
509 Diabetic Retinopathy and
Vascular Biology II
Moderators: Michael H. Elliott and
M. Elizabeth Hartnett
5555 — B0078 Pleiotropic effects of Dll1-
RGD in mice oxygen-induced retinopathy.
Guorui Dou 1, 2 , Y. Wang 1 , H. Han 2 , X. Zhao 2 .
1
Ophthalmology, Xijing Hospital, Xian, China;
2
Developmental Biology and Medical Genetics,
Fourth Military Medical University, Xian, China
5556 — B0079 Mice lacking Adenylyl Cyclase
(AC) 1 and 8 Mimic Supernormal Intraretinal
Ion Channel Activity in Light-adapted Diabetic
Mice But have No Impairment in Visual
Performance. Robin Roberts 1 , A. C. Conti 3, 4 , B. A.
Berkowitz 1, 2 . 1 Anatomy & Cell Biol, Wayne State
Univ Sch of Med, Detroit, MI; 2 Ophthalmology,
Wayne State University School of Medicine,
Detroit, MI, MI; 3 Neurosurgery, Wayne State
University School of Medicine, Detroit, MI, MI;
4
Research Service, John D. Dingell VA Medical
Center, Detroit, MI, MI
5557 — B0080 Detection and Quantification of
VEGF, HIF-1α, HIF-2α and TEAD4 Transcripts
in the Mouse Model of Oxygen-Induced
Retinopathy. Andrew J. Stempel 1 , C. W. Morgans 2 ,
T. Stout 1 , B. Appukuttan 1 . 1 Ophthalmology, Casey
Eye Institute-OHSU, Portland, OR; 2 Physiology
& Pharmacology, Oregon Health & Science
University, Portland, OR *CR
5558 — B0081 Müller Cell Associated
Surfactant Protein A Impairs Retinal Endothelial
Cell Function. Faizah N. Bhatti 1, 2 , G. S. Ball 1 ,
R. R. Akram 1 , M. H. Elliott 2 . 1 Neonatal Perinatal
Medicine, Univ of Oklahoma Hlth Sci Ctr,
Oklahoma City, OK; 2 Ophthalmology, Univ of
Oklahoma Hlth Sci Ctr, Oklahoma City, OK
5559 — B0082 Knockout of IGFBP-3 in Mice
Produces Changes Similar to Chronic Diabetes
in the Retina. Jena J. Steinle 1, 4 , Y. Jiang 1 , Q.
Zhang 1 , L. Liu 4 , B. Peng 3 , J. Pintar 3 , T. S. Kern 2 .
1
Ophthalmology, Univ of Tennessee Hlth Sci Ctr,
Memphis, TN; 2 Ophthalmology and Medicine,
Case Western Reserve University, Cleveland,
Oman; 3 Neuroscience and Cell Biology, UMDNJ-
Robert Wood Johnson Medical School, Piscataway,
NJ; 4 Anatomy and Cell Biology, University of
Tennessee Health Science Center, Memphis, TN
*CR
5560 — B0083 A potential role for cytochrome
P450 epoxygenases and their epoxyeicosatrienoic
acid products in oxygen-induced retinopathy.
Megan E. Capozzi 1 , J. S. Penn 1, 2 . 1 Department of
Molecular Physiology and Biophysics, Vanderbilt
University, Nashville, TN; 2 Department of
Ophthalmology and Visual Sciences, Vanderbilt
University, Nashville, TN *CR
5561 — B0084 Quercetin protects retinal
vascular degeneration through anti-angiogenic
mechanisms in STZ-induced diabetic rats. Binit
Kumar 1 , S. K. Gupta 1 , B. P. Srinivasan 1 , T. C.
Nag 2 , S. Srivastava 1 , R. Saxena 3 . 1 Department of
Pharmacology, Ocular Pharmacology Lab, Delhi
Institute of Pharmaceutical Sciences & Research,
University of Delhi, New Delhi, India; 2 Department
of Anatomy, All India Institute of Medical Sciences,
New Delhi, India; 3 Dr R P Centre For Ophthalmic
Sciences, All India Institute of Medical Sciences,
New Delhi, India
5562 — B0085 Retinal pathology reminiscent
of retinopathy of prematurity in a rat model
for periventricular leucomalacia. Janina Steck 1 ,
C. Blueml 2 , S. E. Kampmann 2 , B. Gerstner 3 , R. F.
Maier 2 , K. Stieger 1 , B. Lorenz 1 . 1 Department of
Ophthalmology, Justus-Liebig-University, Giessen,
Germany; 2 Department of Pediatrics, Phillips-
University, Marburg, Germany; 3 Department of
Pediatric Cardiology, Justus-Liebig-Universtiy,
Giessen, Germany *CR
5563 — B0086 Tweak/Fn14 Pathway is
Involved in Retinal Neovascularization. Hossein
Ameri 1, 2 , R. Liu 1 , Y. Ha 1 , A. A. Paulucci 3 , M.
Motamedi 1, 3 , B. F. Godley 1 , R. G. Tilton 1, 4 , W.
Zhang 1, 2 . 1 Ophthalmology & Visual Sciences,
University of Texas Medical Branch, Galveston,
TX; 2 Neuroscience and Cell Biology, University
of Texas Medical Branch, Galveston, TX; 3 Center
for Biomedical Engineering, University of Texas
Medical Branch, Galveston, TX; 4 Division
of Endocrinology and Stark Diabetes Center,
Department of Internal Medicine, University of
Texas Medical Branch, Galveston, TX
5564 — B0087 Kelch like-ECH-associated
protein 1 (Keap1) and retinal antioxidant defense
in the development of diabetic retinopathy. Qing
Zhong, R. A. Kowluru. Ophthalmology, Wayne State
Univ/Kresge Eye Inst, Detroit, MI
5565 — B0088 Curcumin-induced MiRNAs
Decrease VEGF, VEGFR, and NF-kB Expression
in Human Retinal Endothelial Cells (hRECs)
Under Hyperglycemic Condition. Annie N.
Farrell, E. Y. Hur, J. C. Howell, R. Haque.
Department of Ophthalmology, Emory University,
Atlanta, GA
5566 — B0089 The combined effect with EPO
and VEGF in retinal angiogenesis. Zhihong Yang,
H. Wang, Y. Jiang, M. McCloskey, M. Hartnett.
Moran Eye Center, Salt Lake City, UT *CR
5567 — B0090 Role of Prorenin Receptor
(PRR) and NADPH Oxidase (NOX) in the
Regulation of VEGF in ARPE-19 Cells under
Hyperglycemic Conditions. Rashidul Haque, P.
M. Iuvone, K. S. Choi, D. J. Park, A. N. Farrell,
E. Y. Hur. Department of Ophthalmology, Emory
University School of Medicine, Atlanta, GA
5568 — B0091 Retinal Protease and Collagen
Responses to Increasing Numbers of Intermittent
Hypoxia During Hyperoxia in a Rat Model
for Oxygen-Induced Retinopathy. Kay D.
Beharry 1 , C. L. Cai 2 , P. Sharma 2 , G. B. Valencia 2 ,
D. R. Lazzaro 3 , J. V. Aranda 1 . 1 Pediatrics &
Ophthalmology, State Univ of New York Downstate
Med Ctr, Brooklyn, NY; 2 Pediatrics/Neonatology,
State Univ of New York Downstate Med Ctr,
Brooklyn, NY; 3 Ophthalmology, State Univ of New
York Downstate Med Ctr, Brooklyn, NY
5569 — B0092 Insulin and Angiogenesis:
Excessive Insulin Induces Over-Proliferation
of Tunic Vasculosa Lentis in Mice. Huiyi Chen,
D. P. Hainsworth, L. W. Reneker. Ophthalmology,
University of Missouri-Columbia, Columbia, MO
5570 — B0093 Angiogenic profile of hypoxic
vascular endothelial cells overexpressing RTEF-
1. Binoy Appukuttan 1 , A. J. Stempel 1 , B. Wilmot 2 ,
T. Stout 1 . 1 Ophthalmology, Casey Eye Institute -
OHSU, Portland, OR; 2 OCTRI, OHSU, Portland,
OR *CR
5571 — B0094 Manipulating Pericyte
Contractility Alters Endothelial Growth and
Angiogenic Potential. Jennifer T. Durham, I. M.
Herman. Molecular Physiology and Pharmacology,
Tufts University School of Medicine, Boston, MA
*CR
5572 — B0095 Enhancing function of
endothelial progenitors by targeting the
transforming growth factor-β1/plasminogen
activator inhibitor-1 system. Sergio Caballero 1 ,
S. Hazra 1 , V. Stepps 3 , A. D. Bhatwadekar 1 , M.
E. Boulton 2 , R. N. Mames 4 , S. Bartelmez 3 , M. B.
Grant 1 . 1 Pharmacology/Therapeutics, University
of Florida, Gainesville, FL; 2 Anatomy and Cell
Biology, University of Florida, Gainesville, FL;
3
BetaStem Therapeutics, Inc., San Franscisco, CA;
4
The Retina Center, Gainesville, FL *CR
5573 — B0096 Mechanisms of Hyperoxiainduced
Retinal Endothelial Cell Death and
Senescence. Orla M. Galvin, T. A. Gardiner, D. M.
McDonald. Queen’s University Belfast, Belfast,
United Kingdom
5574 — B0097 SOCS3 inhibits pathologic
angiogenesis. Jean-Sebastien Joyal 1 , A. Stahl 2 , Y.
Sun 1 , Z. Shao 1 , Z. Fu 1 , A. Juan 1 , D. T. Pei 1 , C. G.
Hurst 1 , J. Chen 1 , L. E. Smith 1 . 1 Ophthalmology,
Children’s Hospital, Harvard Med Sch, Boston,
MA; 2 Ophthalmology, University Eye Hospital
Freiburg, Freiburg, Germany
5575 — B0098 The Alternative Complement
System Mediates Neovascularization in
Retinopathy. John H. Sweigard, R. Yanai, K. M.
Connor, P. Y. Gaissert, A. Thanos. Angiogenesis,
Harvard Medical School/MEEI, dorchester, MA
Thursday Posters
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
355

5576 – 5596 – Thursday – Posters
5576 — B0099 Regulation of Retinal
Angiogenesis by a Novel Lactate Receptor,
GPR81. Ankush Madaan 1, 2 , D. Hamel 2 , J. Rivera 2 ,
S. Chemtob 1, 2 . 1 Pharmacology and Therapeutics,
McGill University, Montreal, QC, Canada; 2 CR -
Hospital Sainte Justine, Universite de Montreal,
Montreal, QC, Canada
5577 — B0100 TEAD4 Isoform Inhibits Vessel
Growth in an Aortic Ring Assay. Trevor J.
McFarland, B. Appukuttan, T. Stout. Retina, Casey
Eye Institute-OHSU, Portland, OR *CR
Exhibit Hall B0105-B0137
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retinal Cell Biology
510 Glia in Health and Disease
5589 — B0112 Powerful Beneficial Effects
of Macrophage Colony-stimulating Factor on
Retinal Microglia Proliferation and Vascular
Repair in the Mouse Model of Oxygen-Induced
Retinopathy. Xiaoshuang Jiang, Y. Ni, G. Xu.
Ophthalmology Department, Eye and ENT Hosp of
Fudan University, Shanghai, China
5590 — B0113 Role of Translocator Protein
(TSPO) in the Regulation of Microglial Function
in the Mouse Retina. Minhua Wang 1 , L. Zhao 1 , W.
Ma 1 , R. Fariss 2 , W. T. Wong 1 . 1 Unit on Neuron-Glia
Interations in Retinal Disease, National Institutes
of Health, National Eye Institute, Bethesda, MD;
2
Biological Imaging Core, National Institutes of
Health, National Eye Institute, Bethesda, MD
5591 — B0114 Microglial response to
nanosecond laser application to the retinal
pigment epithelium. Erica L. Fletcher 1 , S.
A. Mills 1 , U. Greferath 1 , R. H. Guymer 2 , M.
J. Plunkett 3 , A. I. Jobling 1 . 1 Dept Anatomy/
Neuroscience, University of Melbourne, Parkville,
VIC, Australia; 2 Centre for Eye Research Australia,
The University of Melbourne, Parkville, VIC,
Australia; 3 Ellex Pty Ltd, Adelaide, SA, Australia
*CR
5592 — B0115 BMP7 Can Act as a Trigger of
Reactive Gliosis in Muller Glia. Subramanian
Dharmarajan 1 , N. Sheibani 2 , T. L. Belecky-Adams 1 .
1
Dept of Biology, IUPUI, Indianapolis, IN;
2
Ophthalmology and Visual Sciences, University of
Wisconsin, Madison, WI
5593 — B0116 Modulation of Müller
glial-neuronal cell interactions attenuates
photoreceptor damage in a novel transgenic
model of conditional Müller cell ablation.
Weiyong Shen, L. Zhu, S. Lee, S. H. Chung, M. C.
Gillies. Clin Ophthal & Eye Health, University of
Sydney, Sydney, NSW, Australia *CR
Thursday Posters
8:30 am – 10:15 am
5578 — B0101 Human adipose stem cell
derived pericytes protect against retinal
vasculopathy in vivo. Thomas A. Mendel 1, 2 , E. B.
Clabough 2, 3 , D. S. Kao 2 , T. N. Demidova-Rice 4, 5 , B.
Zotter 2 , E. P. Rakoczy 6 , A. J. Katz 7, 8 , I. M. Herman 4 ,
S. M. Peirce 9 , P. A. Yates 2 . 1 Pathology, University
of Virginia, Charlottesville, VA; 2 Ophthalmology,
University of Virginia, Charlottesville, VA;
3
Biology, Randolph-Macon College, Ashland, VA;
4
Molecular Physiology and Pharmacology, Tufts
University, Boston, MA; 5 E.L. Steele Laboratory for
Tumor Biology, Harvard Medical School, Boston,
MA; 6 Molecular Ophthalmology, The University of
Western Australia, Nedlands, WA, Australia; 7 Plastic
Surgery, University of Virginia, Charlottesville, VA;
8
Plastic Surgery, University of Florida, Gainesville,
FL; 9 Biomedical Engineering, University of
Virginia, Charlottesville, VA *CR
5579 — B0102 Regulating the Regulator:
MicroRNA-dependent Control of the Proangiogenic
Activity of the Matricellular Protein
CCN1 in Ischemic Retinopathy. Lulu Yan, O.
Szereszowiec, B. Chaqour. SUNY Downstate
Medical Center, Brooklyn, NY
5580 — B0103 Role of Nrf2 in the regulation
of retinal revascularization and pathologic
angiogenesis in oxygen-induced retinopathy.
Yanhong Wei 1 , J. Gong 1 , R. Thimmulappa 2 , S.
Biswal 2 , E. J. Duh 1 . 1 Ophthalmology, Johns
Hopkins University, Baltimore, MD; 2 Bloomberg
School of Public Health, Johns Hopkins University,
Baltimore, MD
Moderators: Erica L. Fletcher and
Przemyslaw Sapieha
5582 — B0105 Gene Expression Changes
in Aging Retinal Microglia: Relationship to
Microglial Support Functions and Regulation of
Microglial Activation. Wenxin Ma 1, 4 , R. Cojocaru 2,
4
, N. Gotoh 2, 4 , L. Gieser 2, 4 , R. Villasmil 3, 4 , T.
Cogliati 2, 4 , A. Swaroop 2, 4 , W. T. Wong 1, 4 . 1 Unit
on Neuron-Glia Interactions in Retinal Disease,
NEI/NIH, Bethesda, MD; 2 Neurobiology-
Neurodegeneration and Repair Laboratory, NEI/
NIH, Bethesda, MD; 3 Flow Cytometry Core
Facility, NEI/NIH, Bethesda, MD; 4 NEI/NIH,
Bethesda, MD
5583 — B0106 Reactive microglia and the
formation of Müller glia-derived retinal
progenitors. Chris Zelinka, M. Scott, A. J. Fischer.
Neuroscience, Ohio State University, Columbus,
OH
5584 — B0107 Dicer Loss Leads to Müller
Cell Gliosis in the Mouse Retina. Vijay P.
Sarthy 1 , V. Dudley 1 , D. Dalkara 2 , D. V. Schaffer 2 ,
J. G. Flannery 2 . 1 Ophthal-Feinberg Med Sch,
Northwestern University, Chicago, IL; 2 Chemical
and Biomolecular Engineering, The Helen Wills
Neuroscience Institute, University of California
Berkeley, Berkeley, CA
5585 — B0108 A Novel Glial Cell in the
Human Retina. Ellen Miller 1 , C. Zelinka 2 , A. J.
Fischer 2 , C. M. Cebulla 1 . 1 Ophthalmology, Havener
Eye Institute, The Ohio State University Wexner
Medical Center, Columbus, OH; 2 Neuroscience, The
Ohio State University, Columbus, OH
5586 — B0109 The Time Course of Gene
Expression during Reactive Gliosis in the Optic
Nerve. Juan Qu, T. C. Jakobs. Ophthalmology,
Massachusetts Eye & Ear Infirmary, Boston, MA
5587 — B0110 Retinal Astrocytes in the
Mouse Model of Oxygen-Induced Retinopathy.
Felicitas Bucher, A. Stahl, G. Martin, H. T. Agostini.
University Eye Hospital Freiburg, Freiburg,
Germany
5588 — B0111 Glia alterations in the retina of
a multiple sclerosis animal model. Heiko Schmid 1 ,
L. Horstmann 1 , F. Kurschus 2 , A. Waisman 2 , B. H.
Dick 1 , S. C. Joachim 1 . 1 Experimental Eye Research
Institute, Knappschaftskrankenhaus Bochum,
Bochum, Germany; 2 Institute for Molecular
Medicine, University Medical Center of the
Johannes Guntenberg University, Mainz, Germany
*CR
5594 — B0117 The change of retinal ganglion
cells and expression of vascular endothelial
growth factor in diabetic rat model. Chankee
Park, J. Kim, H. L. Park. Catholic University of
Korea, Seoul St. Mary’s hospital, Seoul, Republic
of Korea
5595 — B0118 Functional Analysis of Cultured
Astrocytes from the Murine Optic Nerve Head.
Rumi Kawashima, K. Matsushita, S. Usui, K.
Nishida. Osaka University Medical School, Suita,
Japan *CR
5596 — B0119 Retinal glial changes in
Alzheimer’s disease. Malia M. Edwards 1 , D. S.
McLeod 1 , R. Gutierrez-Lanza 2 , J. J. Rodriguez
Arellano 2, 3 , G. A. Lutty 1 . 1 Wilmer Eye Institute,
Baltimore, MD; 2 Department of Neusosciences,
University of the Basque Country UPV/EHU,
Leioa, Spain; 3 Department of Neuroscience,
Ikerbasque, Bizkaia, Spain
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
356

Thursday – Posters – 5997 – 5616
5597 — B0120 Quantitative Profiling of RMG
Cell Surface Proteome Changes in Response
to LPS Treatment. Stefanie M. Hauck 1 , C. von
Toerne 1 , M. Blindert 1 , J. Behler 1 , C. A. Deeg 2 ,
M. Ueffing 3, 1 . 1 Department of Protein Science,
Helmholtz Center Munich, Neuherberg, Germany;
2
Institute of Animal Physiology, Department
for Veterinary Sciences, Faculty of Veterinary
Medicine, LMU Munich, Munich, Germany;
3
Centre of Ophthalmology, University Medical
Centre, Tübingen, Germany
5598 — B0121 Anti-VEGF therapy inhibits
microglial activation and migration in the retina.
Aude Couturier 1, 2 , E. Bousquet 2 , M. Zhao 2 , B.
Goldenberg 2 , Y. De Kozak 2 , F. F. Behar-Cohen 2, 3 .
1
ophthalmology, Hopital Lariboisière, Université
Paris Diderot-Sorbonne Paris Cité, APHP, Paris,
France; 2 UMRS 872 Physiopathology of Ocular
Diseases: Therapeutic Innovations, INSERM,
Paris, France; 3 Ophthalmology, Hopital Hotel Dieu,
Université Paris Descartes, APHP, Paris, France
*CR
5599 — B0122 The Role of Endoglin in
Retinal Neovascularization. Sandra Suarez 2 ,
J. M. Barnett 3 , J. S. Penn 1, 2 . 1 Ophthalmology
and Visual Sciences, Vanderbilt Univ Medical
Center, Nashville, TN; 2 Cell and Developmental
Biology, Vanderbilt University, Nashville, TN;
3
Pharmacology, Vanderbilt University, Nashville,
TN *CR
5600 — B0123 Investigation of Iba1+/NG2+
cells In the Adult Mouse Retina after Ischemia-
Reperfusion Injury with or without Lycium
barbarum polysaccharide treatment. Qian Feng 1 ,
S. Chung 1 , K. So 1, 2 . 1 Department of Anatomy, The
University of Hong Kong, Hong Kong, Hong Kong;
2
Laboratory of Neurodegenerative Diseases, The
University of Hong Kong, Hong Kong, Hong Kong
5601 — B0124 Vitreous Levels of Soluble
Vascular Adhesion Protein-1 and Prorenin
in Proliferative Diabetic Retinopathy. Saori
Takashina 1, 2 , K. Noda 1, 2 , S. Namba 1, 2 , R. Ando 1, 2 ,
M. Murata 1, 2 , C. Yoshizawa 2 , W. Saito 2 , A. Kanda 1, 2 ,
S. Ishida 1, 2 . 1 Laboratory of Ocular Cell Biology
and Visual Science, Hokkaido University Graduate
School of Medicine, Sapporo, Japan; 2 Department
of Ophthalmology, Hokkaido University Graduate
School of Medicine, Sapporo, Japan
5602 — B0125 Are hypoxia and succinate
mediators of renin-angiotensin system related
vascular injury in the retina? Roksana Armani,
A. Agrotis, J. L. Wilkinson-Berka. Immunology,
Monash University, Melbroune, VIC, Australia *CR
5603 — B0126 The involvement of
apolipoprotein E on intraocular angiogenesis.
Yuhei Hashimoto, S. Nakamura, H. Takizawa,
K. Tsuruma, M. Shimazawa, H. Hara. Gifu
Pharmaceutical University, Gifu, Japan
5604 — B0127 Increased expression of
Adenosine A2B receptor in endothelial precursor
cells contributes to diabetes-induced dysfunction.
Rehae C. Miller, M. B. Grant. Pharmacology and
Therapeutics, University of Florida, Gainesville, FL
5605 — B0128 Role of Sp1 transcription factor
in the pathogenesis of diabetic retinopathy.
Kelly Donovan, O. Alekseev, J. Azizkhan-Clifford.
Biochemistry and Molecular Biology, Drexel
University College of Medicine, Philadelphia, PA
5606 — B0129 Knocking Down p75NTR
Expression Prevents Retinal Acellular Capillary
Formation In ProNGF-Overexpression Model.
Ahmed Shanab 1, 2 , B. A. Mysona 1, 2 , S. Matragoon 1, 3 ,
A. B. El-Remessy 1, 2 . 1 Clinical and Experimental
Therapeutic, University of Georgia, Augusta, GA;
2
Vision Discovery Institute, Georgia Health Science
University, Augusta, GA; 3 VA Medical Center,
Charlie Norwood Veterans Affairs Medical Center,
Augusta, GA
5607 — B0130 Angiogenic potency of
endogenous calcitonin gene-related peptide
(CGRP) in mouse model of oxygen-induced
retinopathy. Yuichi Toriyama 1, 2 , Y. Iesato 1, 2 ,
T. Sakurai 2 , A. Kamiyoshi 2 , Y. Ichikawa-
Shindo 1, 2 , T. Shindo 2 , T. Murata 1 . 1 Department
of Ophthalmology, Shinshu University Graduate
School of Medicine, Matsumoto,Nagano, Japan;
2
Department of Cardiovascular Research,
Shinshu University Graduate School of Medicine,
Matsumoto,Nagano, Japan
5608 — B0131 Involvement of netrin-4 in
oxygen induced neovascularisation. Sabrina
V. Klein 1 , A. B. Maier 1 , Y. Liang 2 , N. Kociok 1 , M.
Koch 3 , W. J. Brunken 4 , O. Strauss 1 , A. M. Joussen 1 .
1
Ophthalmology, Charite Universitätsmedizin
Berlin, Berlin, Germany; 2 Ophthalmology,
Peking University, Beijing, China; 3 Institute for
Biochemistry II, University of Cologne, Cologne,
Germany; 4 Department of Ophthalmology and Cell
Biology, SUNY Downstate Medical Center, New
York, NY
5609 — B0132 Annexin V inhibits pathological
retinal angiogenesis but not physiological
retinal vascular development. Satoshi Morooka 1 ,
T. Murakami 1 , M. Nukada 1, 2 , N. Yoshimura 1 .
1
Ophthalmology and Visual Sciences, Kyoto
University, Kyoto, Japan; 2 Shiga Medical Center for
Adults, Shiga, Japan *CR
5610 — B0133 Loss of Caveolin-1 Results in
Blood-Retinal Barrier Permeability, Venous
Enlargement and Mural Cell Alteration. Xiaowu
Gu 1, 2 , S. J. Fliesler 3, 4 , M. H. Elliott 1, 2 . 1 Oklahoma
Center for Neuroscience, University of Oklahoma
Health Sciences Center, Oklahoma City, OK;
2
Department of Ophthalmology, University of
Oklahoma Health Sciences Center, Oklahoma
City, OK; 3 Departments of Ophthalmology
and Biochemistry, SUNY/Buffalo & SUNY
Eye Institute, Buffalo, NY; 4 Research Service,
VAWNYHS, Buffalo, NY
5611 — B0134 Systemic Inflammatory
Stress Provokes Abnormal Retinal Vascular
Development. Sophie Tremblay 1 , S. Favret 1 , F.
Binet 1 , S. Chaychi 2 , A. Polosa 2 , P. Lachapelle 2 ,
S. Chemtob 3 , P. Sapieha 1 . 1 Vision Health,
HMR Research Center, Montreal, QC, Canada;
2
Ophtalmology Department, McGill University-
Children’s Hospital, Montreal, QC, Canada; 3 Foeto-
Maternal Pathologies, CHU Ste-Justine Research
Center, Montreal, QC, Canada
5612 — B0135 Elucidating molecular
mechanisms of blood retina barrier permeability.
Daniel L. Chao 1 , E. Salero 1 , Y. Wang 1 , C. Volmar 2 , J.
L. Goldberg 1 . 1 Ophthalmology, Bascom Palmer Eye
Inst, Univ of Miami, Coral Gables, FL; 2 Psychiatry,
University of Miami, Miami, FL
5613 — B0136 EphA2 Stimulation of
Angiogenesis is Dependent on VEGFR2. Luciana
Ferrara, A. De Erkenez, E. Fassbender, S. Shen,
A. Woolfenden, Y. Qiu, S. H. Poor, K. Anderson, B.
D. Jaffee. Ophthalmology, Novartis Institutes for
Biomedical Research, Cambridge, MA *CR
5614 — B0137 Blockade of transient receptor
potential (TRP) channels inhibits retinal
neovascularization via inhibition of calcium
ion dependent signaling pathway. Hyun Beom
Song 1, 2 , H. Jun 1 , J. Kim 1 , I. Jo 3 , J. Kim 2, 4 . 1 Fight
against Angiogenesis-Related Blindness (FARB)
Laboratory, Clinical Research Institute, Seoul
National University Hospital, Seoul, Republic of
Korea; 2 Department of Biomedical Sciences, Seoul
National University College of Medicine, Seoul,
Republic of Korea; 3 Department of Molecular
Medicine and Ewha Medical Research Institute,
Ewha Womans University Medical School, Seoul,
Republic of Korea; 4 Department of Ophthalmology,
Seoul National University College of Medicine,
Seoul, Republic of Korea
Exhibit Hall C0001-C0049
Thursday, May 09, 2013 8:30 AM-10:15 AM
Glaucoma
511 Intraocular Pressure
Moderator: Arthur J. Sit
5615 — C0001 Postural change in intraocular
pressure between sitting and lying body positions
- a direct comparison of its measurement with an
unmodified Goldmann applanation tonometer,
Tonopen XL, pneumatonometer, and HA-2
hand-held applanation tonometer. Yaniv Barkana.
1
Ophthalmology, Assaf Harofe Medical Center,
Beer Yaakov, Israel; 2 Ophthalmology, Tel Aviv
University, Tel Aviv, Israel *CR
5616 — C0002 A new Tonometer-the Corvis
ST Tonometer Clinical Comparison with
Non-contact, and Goldmann Applanation
Tonometers. Jiaxu Hong, J. Xu, A. Wei, S. X. Deng,
X. Sun. Ophthalmology, Eye & Ear, Nose, Throat
Hospital, Shanghai, China
Thursday Posters
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
357

5617 – 5640 – Thursday – Posters
Thursday Posters
8:30 am – 10:15 am
5617 — C0003 Intraocular pressure
characteristics of subjects with either exfoliation
syndrome or exfoliative glaucoma as determined
with the Water Drinking Test: preliminary
findings. Mehmet C. Mocan 1 , B. Kasım 1 , E. Muz 1 ,
M. Orhan 1 , M. T. Irkec 1 , D. G. Mikropoulos 2 ,
A. P. Konstas 2 . 1 Department of Ophthalmology,
Hacettepe Univ School of Medicine, Ankara,
Turkey; 2 1st Department of Ophthalmology, AHEPA
Hospital, Thessaloniki, Greece *CR
5618 — C0004 Investigation of the Effect
of Gonioscopy on Intraocular Pressure.
Ardalan Aminlari, C. Callahan, I. U. Scott, G. C.
Papachristou, J. Olson. Ophthalmology, Penn State
Hershey Eye Center, Hershey, PA
5619 — C0005 Diurnal Non-Clinic-Measured
Intraocular Pressure Profile in Primary Angle-
Closure Glaucoma Patients. Shaoying Tan, N.
B. Baig, C. C. Tham. Ophthalmology and Visual
Sciences, The Chinese University of Hong Kong,
Hong Kong, Hong Kong *CR
5620 — C0006 The Effect of Child Delivery
Process on the Intraocular Pressure in Healthy
Women. Amit Meshi 1 , S. Armarnik 1 , H. Kaneti 2 , F.
Segev 1 , E. I. Assia 1, 3 , N. Geffen 1 . 1 Ophthalmology,
Meir Medical Center, Kfar-Saba, Israel; 2 Obstetrics
and Gynecology, Meir Medical Center, Kfar-Saba,
Israel; 3 Ein-Tal, Tel Aviv, Israel *CR, f
5621 — C0007 Association of Epidural
Steroid Injections(s) with Intraocular Pressure
Elevation. Deepti Saini 1 , I. U. Scott 1 , C. Callahan 1 ,
J. Malayil 2 , J. Gillon 1 , J. Eckert 2 . 1 Ophthalmology,
Penn State Milton S. Hershey Medical Center,
Hershey, PA; 2 Pain Management, Penn State Milton
S. Hershey Medical Center, Hershey, PA
5622 — C0008 Relationship between Central
Corneal Thickness and Intraocular Pressure in
Indigenous Africans in Nigeria. Nwamalubia N.
Nzelu- Egwuonwu. 1 Ophthalmology, Mass Medical
Mission, Lagos, Nigeria; 2 Ophthalmology, Mass
Medical Mission, Lagos, Nigeria
5623 — C0009 Refined IOP measurement with
rebound tonometry in the rabbit. Hong Zhang 1, 2 ,
D. Yang 1, 3 , C. Ross 1 , J. P. Wigg 1 , S. S. Pandav 1 .
1
Ophthalmology, Ctr for Eye Resrch Australia,
East Melbourne, VIC, Australia; 2 Royal Victorian
Eye and Ear Hospital, Melbourne, VIC, Australia;
3
Harbin Medical University, Harbin, China
5624 — C0010 IOP measurement with I-CARE
Rebound Tonometer, Pneumotonometer and
Tonopen in Sedated Children with Glaucoma
and Controls. Fatemah T. Al-Shamlan 1 , J. Song 1, 2 ,
D. P. Edward 1, 2 , I. Al Jadaan 1 , S. A. Al Shahwan 1 , J.
Morales 1 , A. O. Khan 1 , S. Al-Mesfer 1 , A. H. Awad 1 ,
S. Al Turkmani 1 . 1 King Khalid Eye Specialist
Hospital, Riyadh, Saudi Arabia; 2 Ophthalmology,
Wilmer Eye Institute/Johns Hopkns University,
Baltimore, MD f
5625 — C0011 Twenty-Four-Hour Habitual
Intraocular Pressure in Young, Myopic,
Untreated Open- Angle Glaucoma Patients.
Jeong D. Dawoon, K. S. Michael, L. Kyong Sub,
L. Jong Rak. Ophthalmolgy, Asan Medical Center,
Seoul, Republic of Korea
5626 — C0012 24-Hour Intraocular Pressure
Rhythm in Young Healthy Subjects Evaluated
With Continuous Monitoring Using Contact
Lens Sensor. Christophe Chiquet 1, 2 , B. Mottet 1, 2 ,
F. Aptel 1, 2 , R. Hubanova 1 , J. Pépin 2 , J. Romanet 1 .
1
Department of Ophthalmology, University
Hospital, CHU Grenoble, Grenoble, France; 2 Lab
Hypoxia and Physiopathology, INSERM U1042,
Joseph Fourier University, Grenoble, France *CR
5627 — C0013 Randomized Clinical
Investigation to Assess the Efficacy of
SENSIMED Triggerfish ® Continuous IOP
Monitoring. Milko E. Iliev 1 , J. Thygesen 2 , E.
Vandewalle 3 , J. Garcia-Feijoo 4 , S. Garcia-
Delpech 5 . 1 Ophthalmology, University of Bern,
Bern, Switzerland; 2 Ophthalmology, Copenhagen
University Hospital, Glostrup, Denmark;
3
Ophthalmology, University Hospitals Leuven,
Leuven, Belgium; 4 Ophthalmology, Instituto
de Investigación Sanitaria HCSC, Universidad
Complutense, Madrid, Spain; 5 Ophthalmology,
Hospital Universitario y Politécnico la Fe, Valencia,
Spain *CR, f
5628 — C0014 Single versus Multiple
Measurements for Comparing Group
Intraocular Pressure. Brian Chon 1, 2 , G. Smits 3 ,
S. C. Lin 2 , S. Ianchulev 2, 3 . 1 School of Medicine,
Duke University, Durham, NC; 2 Department of
Ophthalmology, University of California San
Francisco, San Francisco, CA; 3 Transcend Medical,
Menlo Park, CA *CR, f
5629 — C0015 Ocular Hypertension Profile
after Pterygium Excision. Maria Husain, A.
Nguyen, K. Nagi. Ophthalmology, University of
Texas Health Science Center, San Antonio, TX
5630 — C0016 IOP lowing effect of prostanoid
FP and EP3 receptor dual agonist on mouse
eyes. Reiko Yamagishi 1 , K. Nagai 3 , S. Yamane 3 , M.
Aihara 2, 1 . 1 Dept of Ophthalmology Sch of Med,
University of Tokyo, Bunkyo-ku, Japan; 2 Shirato
eye clinic, Tokyo, Japan; 3 Ono Pharmaceutical Co.,
LTD., Osaka, Japan *CR
5631 — C0017 Sub-chronic IOP lowering
effect of AMA0076 and Y-39983 in Dutch Belted
rabbits. Sarah Van de Velde 1 , T. Van Bergen 1 ,
D. Sijnave 1 , K. P. Hollanders 1 , E. Vandewalle 1 ,
L. K. Moons 2 , D. Leysen 3 , I. Stalmans 1 . 1 Lab of
Ophthalmology, KULeuven, Leuven, Belgium;
2
Biology, Zoölogical Institute, KULeuven, Leuven,
Belgium; 3 Amakem Therapeutics, Diepenbeek,
Belgium *CR
5632 — C0018 Altered expression of TGFβ1
and MMP-9 results in elevated intraocular
pressure in mice. Anuja Siwakoti 1 , J. Robertson 2 ,
J. A. West-Mays 2 . 1 Medical Sciences, Mcmaster
University, Hamilton, ON, Canada; 2 Pathology
and Molecular Medicine, McMaster University,
Hamilton, ON, Canada
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
358
5633 — C0019 Sustained Delivery of
Travoprost from a Biodegradable Hydrogel
Punctum Plug for the Treatment of Glaucoma.
Abbe Miller, C. D. Blizzard, A. S. Sawhney, M.
Bassett, P. Jarrett, A. Driscoll, M. O’Connor,
D. Molla, S. Takach. Ocular Therapeutix, Inc.,
Bedford, MA *CR
5634 — C0020 Assessment of Intervisit IOP
Control in Eyes with Advanced Glaucoma. Priya
Patel, N. Pritz, R. D. Fechtner, A. S. Khouri. New
Jersey Medical School, Newark, NJ
5635 — C0021 Short duration intraocular
pressure patterns detected by a contact lens
sensor for 24-hour recording. Kaweh Mansouri 1, 2 ,
R. N. Weinreb 2 , R. Goedkoop 3 , M. Moshtaghi 2 , S.
Dorairaj 4, 2 , A. Tafreshi 2 , J. H. Liu 2 . 1 Glaucoma
sector, Division of Ophthalmology, University
of Geneva, Geneva, Switzerland; 2 Department
of Ophthalmology, Hamilton Glaucoma Center,
University of California, San Diego, La Jolla, CA;
3
Sensimed AG, Lausanne, Switzerland; 4 Department
of Ophthalmology, Mayo clinic, Jacksonville, FL
*CR, f
5636 — C0022 Intraocular pressure after
phacoemulsification in glaucoma patients.
Karine D. Bojikian 1, 2 , M. A. Slabaugh 1 , P. P. Chen 1 .
1
Ophthalmology, University of Washington, Seattle,
WA; 2 Ophthalmology, Universidade Federal de Sao
Paulo, Sao Paulo, Brazil *CR
5637 — C0023 24-hour intraocular pressure
(IOP) fluctuation profile before and after laser
peripheral iridotomy in newly diagnosed subjects
with primary angle closure. Baskaran Mani 1, 2 ,
T. Aung 1, 2 . 1 Singapore Eye Research Institute,
Singapore, Singapore; 2 Ophthalmology, Yong Loo
Lin School of Medicine, National University of
Singapore, Singapore, Singapore *CR
5638 — C0024 Effects of Different Sleeping
Postures on Intraocular Pressure and Ocular
Perfusion Pressure in Healthy Young Subjects.
Chungkwon Yoo, T. Lee, Y. Y. Kim. Department
of Ophthalmology, Korea University College of
Medicine, Seoul, Republic of Korea
5639 — C0025 Intraocular pressure and
central corneal thickness in 91,000 patients.
Shilpa Desai 1 , J. Schallhorn 1 , S. C. Schallhorn 2 , Y.
Ou 1 . 1 Ophthalmology, USCF, San Francisco, CA;
2
Optical Express, San Diego, CA *CR
5640 — C0026 Spectral analysis of intraocular
pressure pulse wave for early prediction of
glaucoma. Magdalena Widlicka 1 , D. Iskander 2 ,
P. Krzyzanowska-Berkowska 3 , M. A. Kowalska 1 .
1
Institute of Physics, Wroclaw University of
Technology, Wroclaw, Poland; 2 Institute of
Biomedical Engineering and Instrumentation,
Wroclaw University of Technology, Wroclaw,
Poland; 3 Department of Ophthalmology, Wroclaw
Medical University, Wroclaw, Poland *CR

Thursday – Posters – 5641 – 5662
5641 — C0027 Intraocular pressure
measured by tonometry and a contact lens
sensor in patients with open angle glaucoma.
Katrin Lorenz 1 , R. Goedkoop 2 , M. M. Keilani 1 ,
N. Berssenbruegge 1 , C. A. Korb 1 , J. Wasielica-
Poslednik 1 , N. Pfeiffer 1 . 1 Department of
Ophthalmology, University Medical Center Mainz,
Mainz, Germany; 2 Sensimed AG, Lausanne,
Switzerland *CR, f
5642 — C0028 Characterization of Vav2/3-
deficient mice with spontaneous IOP elevation.
Keiko Fujikawa 1 , K. Inoue 1 , T. Koshiyama 2 , R.
Yamagishi 3 , M. Aihara 3, 4 . 1 Hokkaido University
Graduate School of Health Science, Sapporo, Japan;
2
Hokkaido University Graduate School of Medicine,
Sapporo, Japan; 3 University of Tokyo Graduate
School of Medicine, Tokyo, Japan; 4 Shirato Eye
Clinic, Tokyo, Japan *CR
5643 — C0029 First implantation of a
telemetric, intraocular pressure sensor in patients
with glaucoma. Niklas Plange, A. Koutsonas, P.
Walter. Dept of Ophthalmology, RWTH Aachen
University, Aachen, Germany *CR, f
5644 — C0030 Comparison of Rebound
Tonometer Icare-Pro and Goldmann Handheld
Applanation Tonometer in Congenital
Glaucoma. Laura Morales-Fernandez, L. Borrego,
J. M. Martinez de la Casa, F. Saenz-Frances,
J. Garcia-Feijoo. Glaucoma, Hospital Clinico,
Madrid, Spain *CR
5645 — C0031 The Effect of the Automated
Visual Field Examination on Intraocular
Pressure (IOP) in Patients with Glaucoma. Sonya
Makhni 1 , D. Dave 1 , M. Karl 2 , J. B. Serle 1 . 1 Mount
Sinai School of Medicine, New York, NY; 2 SUNY
Downstate College of Medicine, Brooklyn, NY *CR
5646 — C0032 Ocular Indications of Partial
Penetrance in Mice Heterozygous for NBCe1
(Slc4a4). Michael F. Romero 1, 2 , H. L. Holmes 1 ,
U. Roy Chowdhury 3 , C. R. Hann 3 , M. Chang 1 , M.
P. Fautsch 3 , A. Chen 1 . 1 Physiology & Biomedical
Engineering, Mayo Clinic College of Medicine,
Rochester, MN; 2 Nephrology & Hypertension,
Mayo Clinic College of Medicine, Rochester, MN;
3
Ophthalmology, Mayo Clinic College of Medicine,
Rochester, MN
5647 — C0033 Microbead Occlusion Model
of Glaucoma in Non-Human Primates. Wendi S.
Lambert, B. J. Carlson, D. J. Calkins. Vanderbilt
Eye Institute, Vanderbilt University Med Center,
Nashville, TN *CR
5648 — C0034 The Role Of Ageing In
Experimental Glaucoma. T. H. Khanh Vu 1, 2 , K.
Cho 1 , M. M. Jager 2 , D. F. Chen 1 . 1 Ophthalmology,
Schepens Eye Research Institute, Boston, MA;
2
Ophthalmology, Leiden University Medical Center,
Leiden, Netherlands *CR
5649 — C0035 Establishment of the ocular
hypertension model using the common
marmoset. Masamitsu Shimazawa 1 , S. Nakamura 1 ,
M. Miwa 2 , K. Tsuruma 1 , M. Aihara 3 , K. Nakamura 2 ,
H. Hara 1 . 1 Molecular Pharmacology, Department
of Biofunctional Evaluation, Gifu Pharmaceutical
University, Gifu, Japan; 2 Department of Behavioral
and Brain Sciences, Primate Research Institute,
Kyoto University, Inuyama, Japan; 3 Department
of Ophthalmology, University of Tokyo School of
Medicine, Tokyo, Japan *CR
5650 — C0036 Intraocular pressure in chronic
users of low-dose oral corticosteroids for
connective tissue disease. Beatriz Gomes 1, 2 , M.
R. Santhiago 1 , H. Moraes 1 . 1 Federal University of
Rio de Janeiro, Rio de Janeiro, Brazil; 2 Bonsucesso
Federal Hospital, Rio de Janeiro, Brazil
5651 — C0037 Changes in intraocular pressure
measurements and corneal biomechanical
properties in eyes with glaucoma using
prostaglandin analogues. Maria Jose Montero, O.
D. Albis-Donado, J. Jimenez-Roman. Glaucoma,
APEC, mexico city, Mexico
5652 — C0038 Effect on intraocular pressure
after intravitreal injection of anti-vascular
endothelial growth factor agents in eyes with
neovascular age related macular degeneration.
Junglim Kim 1 , J. Lee 2 . 1 busan paik hospital, Busan,
Republic of Korea; 2 Yonseiplus eye center, seoul,
Republic of Korea
5653 — C0039 Intraocular Pressure Changes
by Continous Recording Through Triggerfish
Contact Lens Application in Patients Undergoing
Water Drinking Test: Correlation with
Goldmann Readings in Controlateral Eye. Nicola
Ungaro 1 , G. Scazzi 1 , M. Giacosa 1 , M. Tardini 2 , G.
Bacchi 1 , S. A. Gandolfi 2 . 1 Azienda Ospedaliera
Universitaria di Parma, Parma, Italy; 2 Università
degli studi di Parma, Parma, Italy *CR
5654 — C0040 Comparison of the Cellular
Response to Overnight Contact Lens Wear on
the Sclera and Cornea. John G. Flanagan 1, 2 , A. D.
Stavropoulos 1, 5 , D. Luensmann 2, 3 , C. K. Postnikoff 4 ,
M. Gorbet 4, 3 . 1 Dept of Ophthal & Vision Sci, Univ
of Toronto,Toronto Western Hosp, Toronto, ON,
Canada; 2 School of Optometry and Vision Science,
Univeristy of Waterloo, Waterloo, ON, Canada;
3
Centre for Contact Lens Research, Univeristy of
Waterloo, Waterloo, ON, Canada; 4 Systems Design
Engineering, Univeristy of Waterloo, Waterloo, ON,
Canada; 5 Institute of Medical Sciences, Univeristy
of Toronto, Toronto, ON, Canada *CR
5655 — C0041 Are thinner corneas associated
with reduced hystersis? Trupti Patil, R. Sasikumar,
S. A. Devi. Glaucoma, Narayana Nethralaya,
Banglore, India
5656 — C0042 Continuous intraocular
pressure monitoring with a wireless contact lens
and ocular telemetry sensor in patients with
open angle glaucoma: pilot study. Claudia Cortes
Alcocer 1, 2 , J. Jimenez-Roman 1 , F. Gil Carrasco 1 , F.
Del Real 2 . 1 Glaucoma, APEC, Mexico City, Mexico;
2
Universidad La Salle, Mexico City, Mexico
5657 — C0043 Development of an implantable
system for measuring intraocular pressure
in rats. Christopher L. Passaglia 1 , S. Bello 2 ,
R. T. Tzekov 3, 4 , S. S. Malavade 3 . 1 Chemical and
Biomedical Engineering, University of South
Florida, Tampa, FL; 2 Electrical Engineering,
University of South Florida, Tampa, FL;
3
Ophthalmology, University of South Florida,
Tampa, FL; 4 Roskamp Institute, Sarasota, FL *CR
5658 — C0044 24-hour IOP monitoring with
the SENSIMED Triggerfish contact lens: effect
of sleep position and assessment of upward drift.
Laura Beltran-Agullo 1 , J. Cheng 1 , Y. M. Buys 1, 2 ,
F. Jahan 3 , J. G. Flanagan 1, 2 , C. M. Shapiro 3,
1
, N. Hossain 3 , S. Simon-Zoula 4 , G. E. Trope 1, 2 .
1
Ophthalmology, Toronto Western Hospital,
Toronto, ON, Canada; 2 University of Toronto,
Toronto, ON, Canada; 3 Sleep Research Unit,
Toronto Western Hopsital, Toronto, ON, Canada;
4
Sensimed AG, Lausanne, Switzerland *CR, f
5659 — C0045 The Effect of Intravitreal
Kenolog on Intraocular Pressure in Patients
with Glaucoma. Melanie McQueen, J. Tannir, R.
Momi, B. A. Hughes, A. Goyal, M. S. Juzych, C.
Kim, A. M. Eby, F. Fatima, M. H. Peracha. Kresge
Eye Institute, Wayne State University School of
Medicine, Detroit, MI
5660 — C0046 Comparative Agreement
Among Three Methods of Tonometry: Goldmann
Applanation, Transpalpebral, and Dynamic
Contour. Luis A. Zarate 1 , M. García-Huerta 1 ,
R. Castañeda 1 , M. Turati 1 , F. Gil Carrasco 1 ,
J. Jimenez-Roman 1 , J. A. Paczka 2 . 1 Glaucoma,
Asociacion Para Evitar la Ceguera en Mexico,
Mexico, Mexico; 2 Glaucoma, 3. Asistencia e
Investigacion en Glaucoma, A.C, Guadalajara,
Mexico
5661 — C0047 Hemofiltration impact on
intraocular pressure in patients with end stage
renal disease without any evidence of glaucoma.
Ruth Georgina Navarrete Ortega 1 , R. Navarrete
Ortega 1 , H. Perez Grovas 1, 2 . 1 Glaucoma, Hospital
Nuestra Señora De La Luz, México, City, Mexico;
2
Nefrology, Instituto Nacional De Cardiologia
“Ignacio Chavez”, México, City, Mexico f
5662 — C0048 Central Corneal Thickness and
IOP Response to Topical Ocular Hypotensive
Medication in the Low-pressure Glaucoma
Treatment Study. Christopher C. Teng 1, 2 , G. De
Moraes 1, 2 , J. M. Liebmann 2 , D. S. Greenfield 3 , R.
Ritch 1, 4 , T. Krupin 5, 6 . 1 Ophthalmology, Einhorn
Clinical Research Center, New York Eye & Ear
Infirmary, New York, NY; 2 Ophthalmology,
NYU School of Medicine, New York, NY;
3
Ophthalmology, Bascom Palmer Eye Institute,
Palm Beach Gardens, FL; 4 Ophthalmology,
New York Medical College, Valhalla, NY;
5
Ophthalmology, Feinberg School of Medicine,
Northwestern University, Chicago, IL; 6 The
Chicago Center for Vision Research, Chicago, IL
*CR, f
Thursday Posters
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
359

5663 – 5685 – Thursday – Posters
5663 — C0049 Comparison of Intraocular
Pressure Measurements Using a Tono-Pen with
Ocufilm + Cover Versus Examination Glove
Fingertip Cover. Daniel Apple, B. Markowitz.
Ophthalmology, University of South Carolina
School of Medicine, Columbia, SC
5670 — C0141 Inter-ocular Difference of Axial
Lengths in Children with Unilateral Congenital
and Developmental Cataracts. Kathryn M. Haider,
J. Wang, D. C. Mitchell, H. A. Smith, H. A. Smith,
G. Roberts, D. Sprunger, D. E. Neely, D. Plager.
Ophthalmology, Indiana University, Indianapolis,
IN *CR
5671 — C0142 Ophthalmic abnormalities
in children with Developmental Coordination
Disorder: Data from the Avon Longitudinal
Study of Parents and Children. Alex Creavin 1, 2 , R.
Lingam 1 , K. Northstone 1 , C. Williams 1 . 1 School of
social and community medicine, Bristol University,
Bristol, United Kingdom; 2 Ophthalmology,
Cheltenham general hospital, Cheltenham, United
Kingdom
5672 — C0143 IOLunder2 study: outcomes
following surgery with and without primary
intraocular lens implantation in children

Thursday – Posters – 5686 – 5705
5686 — C0157 Development and validation of
a novel functional vision instrument for children
and young people with visual impairment. Val
Tadic 1 , A. Cooper 2 , G. Lewando Hundt 3 , J. S.
Rahi 1, 4 . 1 MRC Centre of Epidemiology for Child
Health, UCL Institute of Child Health, London,
United Kingdom; 2 Psychology Department,
Goldsmiths, University of London, London, United
Kingdom; 3 School of Health and Social Studies,
University of Warwick, London, United Kingdom;
4
UCL Institute of Ophthalmology, London, United
Kingdom
5687 — C0158 A novel measure of visual
function and vision related quality of life for
childhood uveitis. Sheila Angeles-Han 1, 2 , S. Yeh 1, 3 ,
C. McCracken 1 , L. Vogler 1, 2 , K. Rouster-Stevens 1, 2 ,
C. Kennedy 2 , S. R. Lambert 1, 3 , K. Jenkins 2 , S.
Prahalad 1, 2 , C. Drews-Botsch 4 . 1 Pediatrics, Emory
University, Atlanta, GA; 2 Children’s Healthcare
of Atlanta, Atlanta, GA; 3 Ophthalmology, Emory
University, Atlanta, GA; 4 Rollins School of Public
Health, Emory University, Atlanta, GA *CR
5688 — C0159 Effects of Lighting on Test
Performance on the Odom-Robin Visual
Efficiency Near Vision Chart in a School
Aged Population. Robin B. Mumford 1 , S. Silva 2 ,
E. Stoddard 2 , J. V. Odom 3 . 1 Mumford Institute,
Highlands, NJ; 2 After-School All- Stars of NY
CampUs, New York, NY; 3 WVU Eye Institute,
Morgantown, WV *CR
5689 — C0160 Prevalence of Anisocoria and
Association Between Age and Pupil Size in
Children. Jillian Silbert 1 , N. S. Matta 1 , J. Tian 2 ,
E. Singman 2 , D. I. Silbert 1 . 1 Vision Research
Department, Family Eye Group, Lancaster, PA;
2
Wilmer Eye Institute, Johns Hopkins University,
Baltimore, MD *CR
5690 — C0161 Mutation analysis in patients
suspected to have PAX6-related ocular
malformations. Daniel Gratie, E. M. Stone, J.
East, R. F. Mullins, A. V. Drack. Ophthalmology,
University of Iowa, Iowa City, IA *CR
5691 — C0162 Risk Factors of Astigmatism
in the Vision in Preschoolers (VIP) Study.
Jiayan Huang 1 , G. Ying 1 , M. G. Maguire 1 , G.
E. Quinn 2 , M. T. Kulp 3 , E. Ciner 4 , L. A. Cyert 5 ,
D. A. Orel-Bixler 6 , B. Moore 7 . 1 University of
Pennsylvania, Philadelphia, PA; 2 Children’s
Hospital of Philadelphia, Philadelphia, PA; 3 Ohio
State University, Columbus, OH; 4 Salus University,
Elkins Park, PA; 5 Northeastern State University,
Tahlequah, OK; 6 University of California, Berkeley,
CA; 7 New England College of Optometry, Boston,
MA *CR
5692 — C0163 Quality Improvement in
the Ophthalmic Care of Patients with Down
Syndrome through a Comprehensive, Center-
Based Model. Daniel Hammer, S. M. Culican.
Washington University in Saint Louis, Saint Louis,
MO
Exhibit Hall C0164-C0189
Thursday, May 09, 2013 8:30 AM-10:15 AM
Clinical/Epidemiologic Research
513 Myopia, CL
Moderators: Jane E. Gwiazda and
Donald O. Mutti
5693 — C0164 Predicting the onset of myopia:
a retrospective study. Bjorn Drobe 1 , R. de Saint-
André 2, 3 . 1 R&D Singapore, Essilor International,
Singapore, Singapore; 2 Sarl Roger de Saint-André,
Gaillac, France; 3 Centre d’Optométrie, Université
Paris-Sud (Paris 11), Faculté des Sciences d’Orsay,
Les Ulis, France *CR
5694 — C0165 A genome-wide association
study for simple myopia and hyperopia in Twin
Eye Study population. Li Deng. Vision Science,
New England College of Optometry, Boston, MA
5695 — C0166 Heritability of Myopia and
Ocular Biometrics in Koreans: The Healthy
Twin Study. Tae-Young Chung, D. Lim, M. Kim,
M. Lee, E. Chung. Samsung Medical Center, Seoul,
Republic of Korea
5696 — C0167 Larger refractive group
differences in visual activities are found in
children than in young adults. Kara E. Gerger,
J. E. Gwiazda. The New England Coll of Optom,
Boston, MA
5697 — C0168 Refractive Errors and Ocular
Biometry in Singapore Adults: The Singapore
Epidemiology of Eye Disease (SEED) Study. Gus
Gazzard 1, 2 , C. Pan 3 , Y. Zheng 4, 5 , A. R. Anuar 4 , P.
Mitchell 6 , T. Aung 5, 4 , C. Cheng 4, 3 , T. Y. Wong 4, 3 , S.
Saw 3, 4 . 1 Institute of Ophthalmology, UCL, London,
United Kingdom; 2 NIHR Biomedical Research
Centre, London, United Kingdom; 3 Saw Swee Hock
School of Public Health, Singapore, Singapore;
4
SERI, Singapore Eye Research Institute,
Singapore, Singapore; 5 SNEC, Singapore National
Eye Centre, Singapore, Singapore; 6 University of
Sydney, Sydney, NSW, Australia *CR
5698 — C0169 Outdoor activity exhibit
protective effect for myopia in children having
a moderate near workload. Yuanbo Liang 1, 2 , Z.
Lin 3, 2 , B. Vasudevan 4 , V. Jhanji 2 , T. Gao 5 , N. Wang 3 ,
K. J. Ciuffreda 6 . 1 Clinical Research Center, The
Joint Shantou International Eye Center (JSIEC)
of Shantou, Shantou, China; 2 Department of
Ophthalmology and Visual Sciences, The Chinese
University of Hong Kong, Hong Kong, China;
3
Beijing Tongren Eye Center, Beijing Tongren
Hospital, Beijing, China; 4 College of Optometry,
Mid Western University, Glendale, AZ; 5 Handan
Eye Hospital, Handan, China; 6 Department of
Biological and Vision Sciences, SUNY College of
Optometry, New York, NY
5699 — C0170 The effect of light intensity
and accommodation on short-term axial length
changes in myopes and emmetropes. Emma
Chu, J. E. Gwiazda. Vision Science, New England
College of Optometry, Boston, MA
5700 — C0171 International educational
performance and myopia - a role for cram
schools? Ian G. Morgan 1 , K. A. Rose 2 . 1 Research
School of Biology, Australian National University,
Canberra, ACT, Australia; 2 Discipline of Orthoptics,
University of Sydney, Sydney, NSW, Australia
5701 — C0172 Age of Spectacle Wear as a
proxy for myopia severity in genetic studies.
Katie M. Williams 1 , P. G. Hysi 1 , A. Nag 1 , E. Yonova 1 ,
C. Venturini 1, 2 , C. J. Hammond 1 . 1 Departments of
Ophthalmology and Twin Research, King’s College
London, London, United Kingdom; 2 Institute
of Ophthalmology, University College London,
London, United Kingdom
5702 — C0173 Prevalence of myopia at age 6
in a Dutch Birth Cohort Study: The Generation
R Study. Jan Roelof Polling 1, 2 , R. Gaillard 3 ,
A. Hofman 4 , V. Jaddoe 3 , J. R. Vingerling 1, 4 , C.
C. Klaver 1, 4 . 1 Ophthalmology, Erasmus MC,
Rotterdam, Netherlands; 2 Orthoptics & Optomery,
University of Applied Sciences, Utrecht,
Netherlands; 3 Generation R Study Group, Erasmus
MC, Rotterdam, Netherlands; 4 Epidemiology,
Erasmus MC, Rotterdam, Netherlands *CR
5703 — C0174 Peripheral Refraction in a
Population of Schoolage Children in Central
China: the Anyang Childhood Eye Study. Shi-
Ming Li 1 , S. Li 1 , N. Wang 1 , P. Mitchell 2 . 1 Beijing
Tongren Eye Center, Beijing Tongren Hospital,
Beijing, China; 2 Centre for Vision Research,
Department of Ophthalmology and Westmead
Millennium Institute, University of Sydney, Sydney,
ACT, Australia *CR
5704 — C0175 Scleral Encircling Acceleration
or Deceleration of Myopic Progression in Myopic
Eyes. Changho Kim, S. Kim. Ophthalmology,
Severance hospital, Yonsei Univ College of
Medicine, Seoul, Republic of Korea
5705 — C0176 Curry consumption and high
myopia in adults: A possible protective effect.
Ainur R. Anuar 2, 1 , Y. Zheng 1, 3 , L. Huang 1 , B.
Mani 1 , C. Y. Cheung 1 , C. Cheng 1 , M. Chew 1 , J. S.
Mehta 1, 5 , T. Y. Wong 1, 4 , T. Aung 1, 4 . 1 Epidemiology,
Singapore Eye Research Institute, Singapore,
Singapore; 2 Ophthalmology, Faculty of Medicine,
University of Malaya, Kuala Lumpur, Malaysia;
3
State Key Laboratory of Ophthalmology,
Zhongshan Ophthalmic Center, Guangzhou,
China; 4 Department of Ophthalmology, Yong
Loo Lin School of Medicine, National University
of Singapore, Singapore, Yong Loo Lin School
of Medicine, National University of Singapore,
Singapore, Singapore; 5 Duke-NUS Graduate
Medical School of Medicine, National University of
Singapore, Singapore, Singapore *CR
Thursday Posters
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
361

5706 – 5727 – Thursday – Posters
Thursday Posters
8:30 am – 10:15 am
5706 — C0177 Comparison of Cycloplegic
refraction between Retinoscopy, Closed field
and Open field autorefraction in Pseudomyopia.
Jameel Rizwana Hussaindeen, K. Ramani. Elite
School of Optometry, Sankara Nethralaya, Unit of
Medical Research Foundation, Chennai, India
5707 — C0178 Eye shape and peripheral
refraction as predictors of myopia progression in
a population of Chinese children. David Troilo 1 ,
L. Jiang 2 , A. Benavente-Perez 1 , X. Zhou 2 , F. Lu 2 , J.
Qu 2 . 1 SUNY College of Optometry, New York, NY;
2
Wenzhou Medical College, Wenzhou, China
5708 — C0179 Three-Dimensional Modeling
of Highly Myopic Human Eyes Using Optical
Coherence Tomography Imaging. Yumiko Akagi-
Kurashige, K. Yamashiro, M. Miyake, A. Oishi, A.
Tsujikawa, M. Hangai, N. Yoshimura. Department
of Ophthalmology and Visual Sciences, Kyoto
University Graduate School of Medicine, Kyoto,
Japan *CR
5709 — C0180 Biometric characteristics
of the Marfan eye: From the Marfan Eye
Consortium of Chicago. Sarah Wehrli 2, 1 , M.
Mets 1, 2 , I. S. Kassem 3, 1 , A. A. Fawzi 2, 1 , N. F. Azar 3, 1 ,
I. H. Maumenee 3, 1 . 1 Lurie Children’s Hospital of
Chicago, Chicago, IL; 2 Northwestern, Chicago, IL;
3
UIC, Chicago, IL
5710 — C0181 Implementation of atropine
treatment for progressive myopia in children.
Ruben Kok 1 , J. Polling 1, 2 , C. C. Klaver 1, 3 .
1
Ophthalmology, Erasmus MC Rotterdam, the
Netherlands, Rotterdam, Netherlands; 2 Optometry
& Orthoptics, University of Applied Sciences,
Utrecht, Netherlands; 3 Epidemiology, Erasmus
Medical Center, Rotterdam, Netherlands *CR
5711 — C0182 The Economic Cost of
Myopia in Singapore. Seang-Mei Saw 1, 2 , Y.
Zheng 2 , J. Chay 3 , C. Pan 1 , E. L. Lamoureux 2, 3 ,
E. A. Finkelstein 3, 1 , T. Y. Wong 2, 4 . 1 Saw Swee
Hock School of Public Health, National Univ
of Singapore, Singapore, Singapore; 2 Singapore
Eye Research Institute, Singapore Eye Research
Institute, Singapore, Singapore; 3 HSSR, Duke-
NUS Graduate Medical School, Singapore,
Singapore; 4 Ophthalmology, National University
Health System, National University of Singapore,
Singapore, Singapore *CR
5712 — C0183 Correlation in Myopia
Progression between right and left eyes in
Chinese children with Myopia. Padmaja
Sankaridurg 1, 2 , B. A. Holden 1, 3 , X. Chen 4, 2 , A. Ho 1, 3 ,
L. Li 4, 2 , L. Donovan 1, 2 , J. Ge 4 . 1 Optometry, Brien
Holden Vision Institute, Sydney, NSW, Australia;
2
Research, Vision Cooperative Research Centre,
Sydney, NSW, Australia; 3 School of Optometry and
Vision Science, University of New South Wales,
Sydney, NSW, Australia; 4 State Key Laboratory of
Ophthalmology, Zhongshan Ophthalmic Centre,
Guangzhou, China *CR, f
5713 — C0184 Prevalence of myopia in
Chinese urban and rural children. Mingzhi
Zhang. Ophthalmology, Joint Shantou International
Eye Center, Shantou, China
5714 — C0185 Refractive Errors and Age-
Related Macular Degeneration: A Systematic
Review and Meta-Analysis. Chen Wei Pan 1 ,
M. K. Ikram 2, 3 , C. Y. Cheung 2, 3 , G. C. Cheung 2,
3
, J. B. Jonas 4 , T. Y. Wong 2, 3 , S. Saw 1, 2 . 1 Saw
Swee Hock School of Public Health, National
University of Singapore, Singapore, Singapore;
2
Singapore Eye Research Institute, Singapore,
Singapore; 3 Ophthalmology, National University of
Singapore, Singapore, Singapore; 4 Ophthalmology,
Medical Faculty Mannheim of the Ruprecht-Karls-
University Heidelberg, Mannheim, Germany *CR
5715 — C0186 Longitudinal anterior globe
width growth depends on refractive error.
Melissa D. Bailey, N. G. Satiani, L. T. Sinnott.
Optometry, Ohio State University, Columbus, OH
5716 — C0187 Macular Thickness in Myopic
and Mon-myopic Young Adults. Leslie Hyman 1 ,
J. E. Gwiazda 2 , E. Harb 2 , W. L. Marsh-Tootle 3 .
1
Preventive Medicine, Stony Brook Medicine,
Stony Brook, NY; 2 New England College of
Optometry, Boston, MA; 3 UAB College of
Optometry, University of Alabama at Birmingham,
Birmingham, AL
5717 — C0188 Vitamin D receptor gene
polymorphisms and the risk of myopia. Jeremy
A. Guggenheim 1 , K. Northstone 2 , G. McMahon 2 ,
B. St Pourcain 2 , C. Williams 2 . 1 Centre for Myopia
Research, Hong Kong Polytechnic University,
Kowloon, Hong Kong; 2 School of Social and
Community Medicine, University of Bristol,
Bristol, United Kingdom
5718 — C0189 What is the ‘real’ baseline
for the rate of progress of myopia for a
child?The rate of progress of myopia with and
without spectacle vision correction. Li Li 2, 1 , P.
Sankaridurg 1 , T. J. Naduvilath 1 , X. Chen 2 , Z. Lin 2 , B.
A. Holden 1 . 1 Brien Holden Vision Institute, Sydney,
NSW, Australia; 2 Zhongshan Ophthalmic Center,
Guangzhou, China *CR, f
Exhibit Hall C0190-C0200
Thursday, May 09, 2013 8:30 AM-10:15 AM
Clinical/Epidemiologic Research
514 Vision Impairment
Moderators: Priya M. Mathews and Tunde Peto
5719 — C0190 The utility of routine testing
for tuberculosis in a county-hospital uveitis
population. An analysis of predictive values.
Bryan K. Hong, S. R. Bababeygy, H. Nazari
Khanamiri, N. A. Rao. Ophthalmology, Doheny Eye
Institute, LAC & USC, Los Angeles, CA
5720 — C0191 Correlation of Ophthalmic
Screening Tests in an American Indian/Alaskan
Native Cohort. Laura J. Kopplin 1 , D. Choi 3 , S. L.
Mansberger 2 . 1 Casey Eye Institute, Portland, OR;
2
Devers Eye Institute, Portland, OR; 3 Public Health
& Preventive Medicine, Oregon Health and Science
University, Portland, OR *CR
5721 — C0192 The global burden of visual
difficulty. Fawzia Djafari 1, 2 , S. Haddad 3 , M.
Aubin 1, 2 , M. Roy-Gagnon 1 , C. Vela 1 , E. E.
Freeman 1, 2 . 1 Maisonneuve-Rosemont hospital,
Montréal, QC, Canada; 2 Ophthalmology, Université
de Montréal, Montreal, QC, Canada; 3 Centre de
Recherche, Centre Hospitalier de l’Université de
Montréal, Montreal, QC, Canada
5722 — C0193 Improving Visual Prognosis
of Glaucoma Patients during 30 Years based
on the Data of the Finnish Register of Visual
Impairment. Hannu M. Uusitalo 1, 2 , A. Siitonen 1 ,
M. Ojamo 2 . 1 Department of Ophthalmology, SILK,
University of Tampere, Tampere, Finland; 2 Finnish
Register of Visual Impairment, THL, Helsinki,
Finland
5723 — C0194 A New Computerized
Autoacuity Test for Assessment of the Visual
Acuity of Pre-school Children. Mingxing
Wu 1 , Y. Qin 1 , L. Liu 1 , S. Ye 1 , M. Fu 3 , Z. Liu 1 , Y.
Tsau 2 . 1 Cataract, Zhongshan Ophthalmic Center,
Guangzhou, China; 2 Dimetek Digital Medical
Technologies, Limited, Shenzhen, China; 3 Shenzhen
Children and Women Hospital, Shenzhen, China
5724 — C0195 Longitudinal Relationships
between Visual Acuity and Depressive
Symptoms: the Salisbury Eye Evaluation Study.
Dandan D. Zheng 1 , S. L. Christ 2 , S. K. West 3 , B. E.
Munoz 3 , B. K. Swenor 3 , B. L. Lam 4 , D. J. Lee 1, 4 .
1
Epidemiology & Public Health, University of
Miami, Miami, FL; 2 Human Development and
Family Studies, Purdue University, West Lafayette,
FL; 3 Dana Center for Preventive Ophthalmology,
Wilmer Eye Institute, The Johns Hopkins University
School of Medicine, Baltimore, FL; 4 Bascom
Palmer Eye Institute, University of Miami, Miami,
FL
5725 — C0196 The Vision In Stroke (VIS)
study: Profile of visual impairment following
stroke. Fiona J. Rowe. Orthoptics and Vision
Science, University of Liverpool - Sydney Jones
Library, Liverpool, United Kingdom
5726 — C0197 Vision Impairment and Eye
Care Utilization Among Older Adults Residing
in Assisted Living. Amanda Elliott 1 , G. McGwin 2, 3 ,
C. Owsley 2 . 1 Nursing, University of South Florida,
Tampa, FL; 2 Ophthalmology, University of Alabama
at Birmingham, Birmingham, AL; 3 Epidemiology,
University of Alabama at Birmingham,
Birmingham, AL *CR
5727 — C0198 Refractive Error And Cause Of
Vision Impairment Among Children In A Low
Vision Service. Dawn K. DeCarlo 1 , G. McGwin 1, 2 ,
E. L. Forte 1 , L. Gao 1 , C. Owsley 1 . 1 Ophthalmology,
Univ of Alabama at Birmingham, Birmingham,
AL; 2 Epidemiology, University of Alabama at
Birmingham, Birmingham, AL *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
362

Thursday – Posters – 5728 – 5749
5728 — C0199 Estimation of design effect,
sample size and number of clusters needed for
trachoma prevalence surveys. Beatriz E. Munoz 1 ,
J. King 2 , J. M. Ngondi 3 , P. Emerson 2 , S. K. West 1 .
1
Ophthalmology, Johns Hopkins Wilmer Eye
Inst, Baltimore, MD; 2 Carter Center, Atlanta, GA;
3
Public Health and Primary Care, Institute of Public
Health, University of Cambridge, Cambrige, United
Kingdom
5729 — C0200 Visual Acuity and Associated
Risk Factors in indigenous and non-indigenous
Mexican population. Jesus Arrieta-Camacho,
E. O. Graue-Hernández, A. J. Ramirez-Miranda,
A. Jimenez-Corona. Anterior Segment, Inst de
Oftalmologia CONVAL, Mexico City, Mexico *CR
Exhibit Hall C0201-C0224
Thursday, May 09, 2013 8:30 AM-10:15 AM
Lens
515 Chemical Composition and
Physical Properties
Moderator: Ales Cvekl
5730 — C0201 The viscosity of the lens. Mai T.
Thao 1 , D. S. Perez 1 , J. P. Dillon 1 , E. R. Gaillard 1, 2 .
1
Chemistry and Biochemistry, Northern Illinois
University, Dekalb, IL; 2 Biology, Northern Illinois
University, Dekalb, IL
5731 — C0202 Resting Potential of Rat
Crystalline Lens. Sebastiao Cronemberger 1 , V. V.
Oliveira 2 , R. Fleming 2 , N. S. Calixto 1 , A. Dantas 2 .
1
Ophthalmology, Federal University of Minas
Gerais, Belo Horizonte, Brazil; 2 Ophthalmology,
Federal University of Rio de Janeiro, Rio de
Janeiro, Brazil
5732 — C0203 Conformational characteristics
of proteins and lipids in transparent human
lenses and lenses with cortical opacities - A
Raman spectroscopic study. Ralph Michael 1 ,
C. Otto 2 , A. Lenferink 2 , G. A. Montenegro 1 , R. I.
Barraquer 1 , G. Vrensen 3 . 1 Institut Universitari
Barraquer, Barcelona, Spain; 2 Medical Cell
Bio Physics, University of Twente, Enschede,
Netherlands; 3 Leiden University Medical Center,
University of Leiden, Leiden, Netherlands
5733 — C0204 Fiber Cell Compaction in Adult
Human Lenses Begins Near the Remodeling
Zone in the Outer Cortex. M J. Costello 1 ,
A. Mohamed 2 , K. Gilliland 1 , W. C. Fowler 3 , S.
Johnsen 4 . 1 Cell Biology & Physiology, University
of North Carolina, Chapel Hill, NC; 2 Prof. Brien
Holden Eye Research Centre, L V Prasad Eye
Institute, Hyderabad, India; 3 Ophthalmology,
University of North Carolina, Chapel Hill, NC;
4
Biology, Duke University, Durham, NC
5734 — C0205 The Tropomodulin1-Actin
Network and CP49 Beaded Filaments Regulate
Formation of Undulating Aquaporin Junctions
in Mouse Lens Fiber Cells. Sondip K. Biswas 1 , R.
B. Nowak 2 , V. M. Fowler 2 , W. Lo 1 . 1 Neurobiology,
Morehouse School of Medicine, Atlanta, GA; 2 Cell
Biology, The Scripps Research Institute, La Jolla,
CA
5735 — C0206 The Spectrin-Actin Network
and Beaded Filaments Cooperate to Assemble
Large Gap Junction Plaques, Facilitating
Normal Ion Homeostasis in Mouse Lens
Fiber Cells. Velia M. Fowler 1 , R. B. Nowak 1 , J.
Gao 2 , R. T. Mathias 2 , S. K. Biswas 3 , W. Lo 3 . 1 Cell
Biology, Scripps Research Institute, La Jolla, CA;
2
Physiology and Biophysics, State University
of New York at Stonybrook, Stony Brook, NY;
3
Neurobiology, Morehouse School of Medicine,
Atlanta, GA
5736 — C0207 Filensin and CP49 expression
are not restricted to lens fiber cells. Paul G.
FitzGerald 1 , R. A. Quinlan 2 . 1 Cell Biol & Human
Anatomy, Univ of California, Davis, Davis, CA;
2
Biophysical Sciences Institute, Durham University,
Durham, United Kingdom
5737 — C0208 A Putative glutathione
transporter identified in mouse lens with
glutathione de novo synthesis deficiency
(LEGSKO) is also elevated in aged human lens.
Xingjun Fan. Pathology, Case Western Reserve
Univ, Cleveland, OH
5738 — C0209 Metabolite and lipid mapping
in normal and functionally perturbed ocular lens
by MALDI imaging mass spectrometry. Angus
C. Grey 1 , M. G. Nye-Wood 1 , J. M. Spraggins 3 , R.
M. Caprioli 4, 3 , K. L. Schey 4, 3 , P. J. Donaldson 2 .
1
Optometry and Vision Science, University of
Auckland, Auckland, New Zealand; 2 School
of Medical Sciences, University of Auckland,
Auckland, New Zealand; 3 Mass Spectrometry
Research Center, Vanderbilt University, Nashville,
TN; 4 Biochemistry, Vanderbilt University,
Nashville, TN
5739 — C0210 Discovery of key proteins
involved in Parkinson’s disease and Alzheimer’s
disease in human eyes. Chunmei He 1 , J. Zhang 2, 1 ,
T. T. Shen 1 . 1 Ophthalmology, University of
Washington, Seattle, WA; 2 Pathology, University of
Washington, Seattle, WA
5740 — C0211 Danio rerio αB1-crystallin
encodes for an activated chaperone. Hanane A.
Koteiche, S. Mishra, H. S. Mchaourab. Molecular
Physiology and Biophysics, Vanderbilt University,
Nashville, TN
5741 — C0212 Assessing the zebrafish as
an efficient model for analyzing mammalian
α-crystallin transcriptional regulation. Mason
Posner, Z. Haley, A. Drossman. Biology, Ashland
University, Ashland, OH
5742 — C0213 Kinetics of Diabetes Related
Modifications in Heat Shock Proteins.
Devi Kalyan Karumanchi 1 , E. R. Gaillard 1, 2 ,
J. P. Dillon 1 . 1 Department of Chemistry and
Biochemistry, Northern Illinois University, Dekalb,
IL; 2 Department of Biology, Northern Illinois
University, Dekalb, IL
5743 — C0214 UVA light through sensitization
of kynurenines oxidizes ascorbate and promotes
lens protein modification: Implications for lens
aging and cataract formation. Cibin T. Raghavan 1 ,
M. D. Linetsky 2 , R. H. Nagaraj 1 . 1 Ophthalmology,
Case Western Reserve University, Cleveland, OH;
2
Chemistry, Case Western Reserve University,
Cleveland, OH
5744 — C0215 Stimulation of Glycolysis in the
Lens by Pyruvate. Implications in Protection
against Oxidative Stress. Kavita R. Hegde 1 ,
S. D. Varma 2 . 1 Natural Sciences, Coppin State
University, Baltimore, MD; 2 Ophthalmology and
Visual Sciences, University of Maryland School of
Medicine, Baltimore, MD
5745 — C0216 Patterns of Cellular
Expression and Self Assembly of Human
Amyloid Proteins in vivo. Owen Lawrence 1 , J.
L. Dodge 1 , J. M. Clark 1 , J. I. Clark 1, 2 . 1 Biological
Structure, University of Washington, Seattle, WA;
2
Ophthalmology, University of Washington, Seattle,
WA
5746 — C0217 Domain Structure of
Reconstituted Cortical and Nuclear Human Lens
Lipid Membranes. Laxman Mainali 1 , M. Raguz 1, 3 ,
W. J. O’Brien 2 , W. K. Subczynski 1 . 1 Biophysics,
Medical College of Wisconsin, Milwaukee, WI;
2
Ophthalmology and Microbiology/Molecular
Genetics, Medical College of Wisconsin,
Milwaukee, WI; 3 Medical Physics and Biophysics,
University of Split, Split, Croatia
5747 — C0218 Mice Expressing CRYAAN101D
Show Altered Membrane Structure and
Increased Membrane-Association of Deamidated
αA Compared to CRYAA Wild-Type (WT) Mice.
Kiran Srivastava, R. Joseph, S. M. Hegde, O. P.
Srivastava. Vision Sciences, University of Alabama
at Birmingham, Birmingham, AL
5748 — C0219 Probing structure of human
β-crystallins by protein cross-linking. Kirsten
J. Lampi 1 , L. L. David 2 . 1 Integrative Biosciences,
Oregon Health and Science University, Portland,
OR; 2 Biochemistry and Molecular Biology, Oregon
Health and Science University, Portland, OR
5749 — C0220 Oxygen Metabolism in Primary
Human Lens Epithelial Cells. Miyuki Kubota 1, 2 ,
C. J. Siegfried 1 , Y. Shui 1 , F. Bai 1 , A. J. Huang 1 , D.
C. Beebe 1, 3 . 1 Ophthalmology & Visual Sciences,
Washington University School of Medicine, St
Louis, MO; 2 Ophthalmology, Keio University
School of Medicine, Tokyo, Japan; 3 Cell Biology
and Physiology, Washington University School of
Medicine, St. Louis, MO *CR
Thursday Posters
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
363

5750 – 5768 – Thursday – Posters
Thursday Posters
8:30 am – 10:15 am
5750 — C0221 Gap junctional conductance
produced by Cx50, but not Cx46, is regulated by
the PI3K signaling pathway in the lens. Jennifer
M. Martinez 1 , H. Wang 1 , P. V. Mhaske 1 , C. Sellitto 1 ,
M. Srinivas 2 , R. Z. Lin 1 , T. W. White 1 . 1 Physiology,
Stony Brook University, Patchogue, NY; 2 Biological
Sciences, State University of New York- College of
Optometry, New York, NY
5751 — C0222 Cell transduction of
αA-crystallin is negatively impacted by
phosphorylation mimics. Niklaus H. Mueller,
K. L. Christopher, D. A. Ammar, J. M. Petrash.
Ophthalmology, Univ of Colorado School of
Medicine, Aurora, CO *CR
5752 — C0223 αB-Crystallin secretion from
astrocytes and its implications for Alzheimer’s
Disease. Juliet A. Moncaster 1, 2 , J. Ghosh 1 , T.
Ikezu 2 , J. C. Voss 3 , R. K. Gangalum 4 , S. Sarangi 1 ,
C. R. Abraham 2 , S. P. Bhat 4 , P. K. Stanton 5 , L. E.
Goldstein 1, 2 . 1 Psychiatry, School of Medicine,
Boston University, Boston, MA; 2 BU Alzheimer’s
Disease Center, School of Medicine, Boston
University, Boston, MA; 3 Biochemistry and
Molecular Medicine, UC Davies, Sacramento, CA;
4
Ophthalmology, Jules Stein Eye Institute, Los
Angeles, CA; 5 Cell Biology and Anatomy, New
York Medical College, Valhalla, NY *CR
5753 — C0224 Chaperone peptides of
α-crystallin inhibit cataract formation in rats.
Rooban B. Nahomi 1 , B. Wang 2 , C. T. Raghavan 1 ,
O. Voss 3 , A. Doseff 3 , P. Santhoshkumar 4 , R. H.
Nagaraj 1 . 1 Ophthalmology, Case Western Reserve
University, Cleveland, OH; 2 Center for Proteomics
and Bioinformatics, Case Western Reserve
University, Cleveland, OH; 3 Davis Heart and Lung
Research Institute, The Ohio State University,
Columbus, OH; 4 Ophthalmology, University of
Missouri, Columbia, MO
Exhibit Hall D0001-D0006
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retina
516 Trauma
Moderator: Hugo Quiroz-Mercado
5754 — D0001 High-Power Blue Laser Pointer-
Induced Maculopathy. sulaiman M. Alsulaiman 1 ,
A. A. Alrushood 1 , J. Almasaud 1 , S. Alzaaidi 1 , Y.
A. Alzahrani 1 , J. Arevalo 1, 2 , N. G. Ghazi 1 , E. B.
Abboud 1 , S. Alreshaid 1 . 1 King Khaled Eye Specialist
Hospital, Riyadh, Saudi Arabia; 2 Wilmer Eye
Institute, Baltimore, MD
5755 — D0002 The effects of repeated exposure
to low level blast overpressure on rat ocular
tissues. Jae Hyek Choi 1, 2 , W. A. Greene 1, 2 , M.
Chavko 3 , A. J. Johnson 2 , J. M. Cleland 2 , H. H.
Wang 2 . 1 National Research Council, Washington,
DC; 2 Ocular Trauma Department, U.S. Army
Institute of Surgical Research, Fort Sam Houston,
TX; 3 NeuroTrauma Department, Naval Medical
Research Center, Silver Spring, MD
5756 — D0003 A prospective study on Terson’s
syndrome and intraocular infections in critically
ill patients. Daniel Barthelmes 1, 2 , M. Haenggi 2 ,
T. M. Merz 2 , J. Takala 2 , M. Lensch 2 , S. M. Jakob 2 .
1
Ophthalmology and Eye health, The University
of Sydney, Sydney, NSW, Australia; 2 Intensive
Care Medicine, University Hospital Bern, Bern,
Switzerland
5757 — D0004 Torsion-Induced Traumatic
Optic Neuropathy (TON). Matthew A. Reilly 1 ,
R. E. Sponsel 1, 2 , R. D. Glickman 3 . 1 Biomedical
Engineering, University of Texas at San Antonio,
San Antonio, TX; 2 WESMDPA, San Antonio,
TX; 3 Ophthalmology, University of Texas Health
Science Center San Antonio, San Antonio, TX *CR
5758 — D0005 Pars Plana Vitrectomy with
medium-term Perfluoro-N-Octane for severe
ocular trauma and hemorrhage with or without
retinal detachment. Ramanath Bhandari 1 ,
S. Schwartz 2 , C. Gonzalez 2 , R. Victoria 2 , N.
Mandava 1 , H. Quiroz-Mercado 2 . 1 Ophthalmology,
Rocky Mountain Lions Eye Institute, University
of Colorado School of Medicine, Aurora, CO;
2
Ophthalmology, Denver Health Medical Center,
Denver, CO *CR
5759 — D0006 Outcome of Retinal Surgery
in Eyes with Ruptured Globes. Khoa V. Lam 1 ,
D. Xing 2 , E. K. Chin 2 , S. S. Park 2 . 1 UC Davis
School of Medicine, Davis, CA; 2 Department
of Ophthalmology & Vision Science, Univ of
California Davis Eye Ctr, Sacramento, CA
Exhibit Hall D0007-D0010
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retina
517 Laser/Intravitreal Treatment
Moderator: Robert L. Avery
5760 — D0007 A comparison of anti-VGEF
therapy and laser in preserving visual function in
patients with proliferative diabetic retinopathy.
Marisol Estudillo, V. H. Gonzalez. Opthalmology-
Retina, Valley Retina Institute,PA, McAllen, TX
*CR, f
5761 — D0008 Intravitreal Ranibizumab
Combined with Panretinal Photocoagulation
in Patients with Treatment-Naive Proliferative
Diabetic Retinopathy. Daniel A. Ferraz 1, 2 , R.
Sophie 2 , M. G. Bittencourt 2 , R. C. Preti 1 , L. M.
Vazquez 1 , A. A. Motta 1 , M. Hanout 2 , Y. J. Sepah 2 ,
Q. Nguyen 2 , W. Y. Takahashi 1 . 1 Ophthalmology,
University of São Paulo, São Paulo, Brazil; 2 Retinal
Imaging Research and Reading Center, Wilmer Eye
Institute, Johns Hopkins University, Baltimore, MD
*CR
5762 — D0009 Rescue Laser Photo Stimulation
for Diabetic Macular Edema Unresponsive to
Anti-VEGF Therapy. Jose A. Cardillo 1, 2 , A. J.
Dare 4 , R. Peroni 3, 4 , R. Jorge 2 . 1 Retina Department,
Universidade Federal de São Paulo, São Paulo,
Brazil; 2 Retina Department, Universidade de São
Paulo, Ribeirão Preto, Brazil; 3 Retina Department,
Hospital de Olhos de Araraquara, Araraquara,
Brazil; 4 Retina Department, Centro Brasileiro de
Especialidades Oftalmológicas, Araraquara, Brazil
5763 — D0010 A Simple Artificial Eye
Model for Practicing Anterior and Posterior
Segment Lasers. Malav Joshi, T. W. Altenbernd.
Ophthalmology and Vision Science, University of
Arizona, Tucson, AZ
Exhibit Hall D0011-D0057
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retina
518 Vitreoretinal Surgery III
Moderator: Elliott H. Sohn
5764 — D0011 The Effect of Internal Limiting
Membrane Peeling in Epiretinal Membrane
Including Pseudolamellar Macular Hole. Jung
Min Park 1 , S. Oh 1 , S. Lee 2 . 1 Ophthalmology,
Maryknoll Hospital, Busan, Republic of Korea;
2
Ophthalmology, Haeundae paek hospital, Busan,
Republic of Korea
5765 — D0012 Clinical Findings at Initial
Pan Retinal Photocoagulation for Proliferative
Diabetic Retinopathy Predict Future Need for
Pars Plana Vitrectomy. Ravi Parikh 1, 4 , J. Van
Houten 3 , E. F. Cherney 2 . 1 School of Medicine,
Vanderbilt University, Nashville, TN; 2 Vanderbilt
Eye Institute, Vanderbilt University Medical Center,
Nashville, TN; 3 Biomedical Informatics, Vanderbilt
University Medical Center, Nashville, TN; 4 Health
Policy and Management HSPH, Harvard University,
Boston, MA
5766 — D0013 Retinal ganglion cell layer
thickness reduces after internal limiting
membrane peeling during macular hole
surgery. Adil Darugar, V. Caillaux, A. Erginay,
B. M. Dupas, V. Krivosic, J. Perol, S. Bruneau, A.
Gaudric, P. Massin, R. Tadayoni. Department of
Ophthalmology, Hôpital Lariboisière, Université
Paris Diderot - Sorbonne Paris Cité, AP-HP, Paris,
France, Paris, France *CR
5767 — D0014 Trends in choice of surgical
technique and reimbursement for retinal
detachment repair. Baseer Ahmad, G. K. Shah, K.
J. Blinder. The Retina Institute / Retina Consultants
of St. Louis, St. Louis, MO *CR
5768 — D0015 Retained Lens Fragments
After Cataract Surgery: Outcomes of Same-Day
Versus Delayed Pars Plana Vitrectomy. Yasha
S. Modi, A. E. Epstein, W. E. Smiddy, W. J. Feuer,
H. W. Flynn. Ophthalmology, Bascom Palmer Eye
Institute, Miami, FL *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
364

Thursday – Posters – 5769 – 5790
5769 — D0016 Anatomical outcomes of
epiretinal membrane surgery with or without
internal limiting membrane peeling. Sheyman,
J. S. Myung, T. Lyu, K. Wald. Department of
Ophthalmology, Mount Sinai School of Medicine,
New york, NY
5770 — D0017 One-year anatomical and
functional outcomes after macular hole surgery:
a prospective controlled study. Sumeer Thinda, R.
J. Shah, S. J. Kim. Ophthalmology, Vanderbilt Univ
Medical Center, Nashville, TN f
5771 — D0018 Retrospective analysis of laser
therapy versus observation for symptomatic
retinal artery macroaneurysms. Jacob C. Meyer,
G. K. Shah. The Retina Institute, St. Louis, MO
*CR
5772 — D0019 Ultrastructural changes of the
vitreoretinal interface during longterm followup
after the removal of the internal limiting
membrane. Toshio Hisatomi 1, 2 , H. Enaida 1 , S.
Notomi 1 , Y. Sassa 1 , A. Takeda 1 , T. Ishibashi 1 .
1
Ophthalmology, Kyushu Univ., Fukuoka, Japan;
2
Clinical Research Institute, Kyushu Medical
Center, Fukuoka, Japan *CR
5773 — D0020 Evaluation of Brilliant Blue
Green (BBG) Toxicity on Retinal Ganglion Cells
Exposed to Varying levels of Illumination with
Surgical Metal Halide Endoilluminator. K V
Chalam, W. Li, S. Balaiya. Ophthalmology, Univ of
Florida-Jacksonville, Jacksonville, FL
5774 — D0021 Outcomes of Transpupillary
Posterior Chamber Intraocular Lens Removal
with Pars Plana Vitrectomy and Placement of
Anterior Chamber Intraocular Lens. Pavlina
Kemp, A. T. Johnson, J. C. Folk, S. R. Russell, V.
B. Mahajan, H. Boldt, T. A. Oetting, E. H. Sohn.
Department of Ophthalmology, University of Iowa,
Iowa City, IA *CR
5775 — D0022 Microfiltration of Brilliant Blue
G Dye. Sri Krishna Mukkamala. 1 Ophthalmology,
Columbia University, New York, NY; 2 Vitreous
Retina Macula Consultants, New York, NY
5776 — D0023 Traumatic Optic Neuropathy
after Vitrectomy Surgery: A controlled
prospective trial. Sivashakthi Kanagalingam, M.
Lalezary, S. J. Kim. Ophthalmology, Vanderbilt
University Medical Center, Nashville, TN f
5777 — D0024 Macular hole surgery: Does
C3F8 provide better anatomical and functional
outcomes than SF6 and C2F6? Javier Zarranz-
Ventura 1, 2 , A. Sallam 1 , P. A. Keane 2 , D. A. Sim 2 , N.
Kirkpatrick 1 , R. Johnston 1 . 1 Vitreo-Retinal Service,
Cheltenham General Hospital, Cheltenham, United
Kingdom; 2 Medical Retina Service, National
Institute for Health Research (NIHR) Biomedical
Research Centre at Moorfields Eye Hospital
NHS Foundation Trust and UCL Institute of
Ophthalmology, London, United Kingdom *CR
5778 — D0025 Retinal Vascular Remodeling
Following Macular Hole Surgery. Gene Chen 1 ,
R. Iezzi 1 , J. W. McLaren 1 , R. C. Gentile 2 , A. J.
Barkmeier 1 . 1 Ophthalmology, Retina, Mayo Clinic,
Rochester, MN; 2 Ophthalmology, Retina, New York
Eye and Ear Infirmary, New York City, NY
5779 — D0026 One-year results of the
Prospective Retinal and Optic nerve Vitrectomy
Evaluation (PROVE) Study: A controlled clinical
trial. Rohan J. Shah, M. Lalezary, S. J. Kim, R.
Reddy, J. Kammer, R. W. Kuchtey, K. M. Joos, F.
Recchia, E. F. Cherney, J. C. Law. Department of
Ophthalmology, Vanderbilt University, Nashville,
TN *CR, f
5780 — D0027 Association of M2 macrophages
in the development of fibrovascular membranes
in diabetic retinopathy. Yoshiyuki Kobayashi 1 , S.
Yoshida 1 , S. Nakao 1 , T. Tachibana 1 , T. Nakama 1 ,
K. Ishikawa 1 , Y. Sassa 1, 2 , H. Enaida 1 , Y. Oshima 1 ,
T. Ishibashi 1 . 1 Ophthalmology, Kyushu University,
Fukuoka, Japan; 2 Ophthalmology, Fukuoka
University Chikushi Hospital, Fukuoka, Japan
5781 — D0028 Quantitative assessment of
Differences in Macular Visibility through a
Variety of Intraocular Lenses during Vitrectomy:
an Eye Model Experimental Study. Hirokazu
Sakaguchi 1 , J. Hidaka 2 , Y. Oshima 1 , N. Maeda 1 ,
K. Nishida 1 . 1 Ophthalmology, Osaka University
Graduate School of Medicine, Suita, Japan; 2 HOYA
Corporation Medical Division, Itabashi, Japan *CR
5782 — D0029 Risk factors for development of
full thickness macular holes following pars plana
vitrectomy for myopic foveoschisis. Yasushi Ikuno,
X. Gao, S. Fujimoto, K. Nishida. Department of
Ophthalmology, Osaka Univ Medical School, Suita,
Japan *CR
5783 — D0030 Clinical Efficacy and Safety
of Dexamethasone/Netilmicin Gel in the
Management of Ocular Inflammation After
Vitreoretinal Surgery. Vincenzo Papa 1 , D. Rasà 1 ,
C. Iannacone 3 , C. Cannatella 1 , A. Rapisarda 2 .
1
Medical Affairs, SIFI SPA, Catania, Italy;
2
Ophthalmology Unit, Garibaldi Hospital, Catania,
Italy; 3 Department of Statistics, Sparc Consulting
Srl, Milano, Italy *CR, f
5784 — D0031 Cone implicit time as a
predictor for visual outcome in Macular Hole
Surgery. Sten Andreasson, S. Kjellstrom, H. Barth,
F. K. Ghosh. Ophthalmology, University Hospital of
Lund, Lund, Sweden
5785 — D0032 One Year Clinical Outcomes
Of A Randomized Clinical Trial Investigating
Pre-operative Adjunctive Bevacizumab For
Tractional Retinal Detachment (TRD) Due
To Proliferative Diabetic Retinopathy (PDR).
Elizabeth O. Tegins 1 , M. Javaheri 2 , D. Eliott 4, 2 ,
L. A. Kim 2, 4 , H. Salehi-Had 2, 5 , D. R. Hinton 2, 3 , E.
H. Sohn 1, 2 . 1 Department of Ophthalmology and
Visual Sciences, University of Iowa, Iowa City,
IA; 2 Doheny Eye Institute, University of Southern
California and Los Angeles County Hospitals,
Los Angeles, CA; 3 Departments of Pathology
and Ophthalmology, Keck School of Medicine,
University of Southern California, Los Angeles,
CA; 4 Massachusetts Eye and Ear Infirmary, Boston,
MA; 5 Atlantis Retina Institute, Huntington Beach,
CA *CR, f
5786 — D0033 Diluted Preserved
Triamcinolone Acetonide for Internal Limiting
Membrane Staining: Staining Morphology
and Cytotoxicity Evaluations. Jerry Huang 1 , L.
Yeung 1 , N. Wang 2 , Y. Chen 2 , Y. Hwang 2 , K. Chen 2 ,
W. Wu 2 , T. Chen 2 , C. Lai 2 . 1 Chang-Gung Memorial
Hospital, Keelung, Taiwan, Keelung City, Taiwan;
2
Chang-Gung Memorial Hospital, Taoyuan, Taiwan,
Guishan Township, Taoyuan County, Taiwan
5787 — D0034 A computational study
of the pressure burden on localized retina
during vitrectomy. Yong Joon Kim 1 , K. Choi 1 ,
S. Jo 2 , Y. Joo 2 . 1 Department of Ophthalmology,
Soonchunhyang University, College of Medicine,
Seoul, Republic of Korea; 2 Department of
Mechanical Engineering, Soonchunhyang
University, Asan, Republic of Korea
5788 — D0035 Iatrogenic retinal breaks in
25-gauge air vitrectomy compared with the
standard 25-gauge system for macular diseases.
Cesare Mariotti 1 , F. Viti 1 , T. Avitabile 2 , M. D.
Toro 2 , A. Saitta 1 , A. Giovannini 1 , A. Longo 2 , V.
De Grande 2 , S. Stella 2 , M. Reibaldi 2 . 1 Clinica
Oculistica, Universita Politecnica delle Marche,
Ancona, Italy; 2 Ophthalmology, University of
Catania, Catania, Italy
5789 — D0036 Dynamic Contour Tonometry
versus Goldmann Applanation Tonometry
after vitrectomy. Nikolaos Mamas, M. Fuest,
G. Roessler, B. A. Mazinani, N. Plange.
Ophthalmology, RWTH Aachen University, Aachen,
Germany *CR
5790 — D0037 Macular hole repair closure
rates in phakic and non-phakic patients with
nonsupine positioning and sulfur hexafluoride
endotamponade. Jaafar El Annan 1 , J. Heffez 3 , J.
D. Udoetuk 1 , M. M. Sanghvi 2 , P. E. Carvnounis 1 .
1
Ophthalmology, Baylor College of Medicine,
Houston, TX; 2 George Washington University
School of Medicine and Health Sciences,
Washington, DC; 3 Retina Consultants P.C.,
Washington, DC *CR
Thursday Posters
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
365

5791 – 5817 – Thursday – Posters
Thursday Posters
8:30 am – 10:15 am
5791 — D0038 Efficacy of pneumatic
displacement of sub macular haemorrhage
(SMH) secondary to wet age related macular
degeneration (ARMD). Indu Kumar, T.
Papathomas, A. Kamal. Ophthalmology, Aintree
University Hospital, Liverpool, United Kingdom
5792 — D0039 Movement of fovea toward
optic disc after macular hole surgery with
internal limiting membrane peeling. Kenichi
Kawano 1 , Y. Ito 1 , M. Kondo 1, 2 , H. Terasaki 1 .
1
Opthalmology, Nagoya University, Nagoya, Japan;
2
Opthalmology, Mie University, Tsu, Japan
5793 — D0040 Course of Intra-Ocular
Pressure After Vitreoretinal Surgery With
Silicone Oil Injection: A Follow-Up of 5 Years.
Elyse Jabbour 1 , G. Azar 1, 2 , J. Antoun 1 , A. Jalkh 1, 2 .
1
Ophthalmology, Eye & Ear University Hospital,
Beirut, Lebanon; 2 Department of Medicine,
Université Saint Esprit Kaslik (USEK), Beirut,
Lebanon
5794 — D0041 27-gauge sutureless
microincision vitrectomy surgery for various
retinal pathologies. Stanislao Rizzo, F. Genovesi-
Ebert, F. Barca, E. Di Bartolo. UO Chirurgia
Oftalmica, Azienda Ospedaliero-Univ Pisana, Pisa,
Italy
5795 — D0042 Anatomic and functional followup
of patients with an idiopathic epiretinal
membrane and a preserved visual acuity. Arnaud
Bonnabel, R. Isaico, A. M. Bron, C. Creuzot-
Garcher. Ophthalmology, General Hospital, Dijon,
France *CR
5796 — D0043 To develop a new surgical
strategy for removing emulsified droplets in
the eye to reduce the complications associated
the use of silicone oil (SO). Yau Kei J. Chan 1 , H.
Shum 2 , S. Wong 1 . 1 Department of Ophthalmology,
University of Hong Kong, Pokfulam, Hong Kong;
2
Department of Mechanical Engineering, University
of Hong Kong, Hong Kong, Hong Kong
5797 — D0044 Blood flow changes of the
retina and choroid after vitrectomy for
epiretinal membrane measured by laser speckle
flowgraphy. Eiko Tsuiki, K. Suzuma, Y. Maekawa,
T. Kitaoka. Department of Ophthalmology and
Visual Sciences, Graduate School of Biomedical
Sciences, Nagasaki University, Nagasaki, Japan
5798 — D0045 Vitreous oxygenation bioimplant
for central retina artery occlusion.
Raul Velez-Montoya, J. Olson. Ophthalmology,
University of Colorado, Aurora, CO *CR
5799 — D0046 Epiretinal Membrane Peeling
Following Uncomplicated Primary Retinal
Detachment Repair. Kyle Godfrey 1 , T. Banker 2 ,
E. Weichel 3, 2 . 1 Georgetown University School
of Medicine, Washington, DC; 2 Ophthalmology,
Georgetown University Hospital, Washington, DC;
3
Retina Group of Washington, Washington, DC
5800 — D0047 Vitreous levels of MCP-1
and CD163 in vitreoretinal diseases. Takashi
Tachibana, S. Yoshida, Y. Kobayashi, T. Nakama, K.
Ishikawa, S. Nakao, Y. Sassa, H. Enaida, Y. Oshima,
T. Ishibashi. Kyushu University, Fukuoka, Japan
5801 — D0048 Vitrectomy for macular hole
secondary to blunt ocular trauma. Satomi Ohta,
T. Baba, S. Yamamoto. Chiba University, Chiba,
Japan
5802 — D0049 Rate of Elevated Intraocular
Pressure Post Primary Vitrectomy Surgery.
Milad Hakimbashi 1, 2 , K. A. Rezaei 2, 1 .
1
Ophthalmology, Rush University, Chicago,
IL; 2 Ophthalmology, Illinois Retina Associates,
Chicago, IL *CR
5803 — D0050 An Experimental Proliferative
Vitreoretinopathy (PVR) Model in Pigmented
Rabbits for Testing of New Treatment. Lichun
Zhong. Ocular Science Department, Toxikon
Corporation, Bedford, MA
5804 — D0051 Light Microscopy Features of
Epiretinal Membranes. Laura N. Distefano 2 , M.
Dutra Medeiros 5 , A. Salas Torras 2 , A. R. Carvalho 2 ,
M. Dinarès i Fernández 3 , F. Tresserra 4 , M. A.
Zapata 1, 2 , J. Garcia-Arumi 1, 2 . 1 Retina and Vitreous,
Vall d’ Hebron Hospital, Barcelona, Spain; 2 Vall
d’Hebron Research Institute, Barcelona, Spain;
3
Anatomical Pathology, Vall d’Hebron Hospital,
Barcelona, Spain; 4 Anatomical Pathology, Instituto
Universitario USP Dexeus, Barcelona, Spain;
5
Centro Hospitalar Lisboa Central, Lisboa, Portugal
5805 — D0052 Treatment of Surgically
Induced Cystoid Macular Edema by Intravitreal
Implant of Dexamethasone. Rino Frisina.
Ophthalmology, Sant’Anna Hospital, Brescia, Italy
5806 — D0053 Anatomic and Visual Success
after Macular Hole Surgery in an Asian
population. Karen Chia, H. Wong. Ophthalmology,
National Healthcare Group Eye Institute, Tan Tock
Seng Hospital, Singapore, Singapore, Singapore
5807 — D0054 Cutter Velocities of Two
Vitrectomy Probes: Dual Pneumatic and a Single
Pneumatic Drive With Spring Return. Dina Joy
K. Abulon. Medical Affairs, Alcon Labs, Irvine, CA
*CR
5808 — D0055 Robot assistance for micrometer
precision in vitreoretinal surgery. Thijs H.
Meenink 1, 2 , G. Naus 1, 2 , M. D. de Smet 3, 4 , M.
Beelen 1, 2 , M. Steinbuch 1 . 1 Mechanical Engineering,
Technische Universiteit Eindhoven, Eindhoven,
Netherlands; 2 PRECEYES Medical Robotics,
Eindhoven, Netherlands; 3 Ophthalmology, Clinique
de Montchoisi, Lausanne, Switzerland; 4 Department
of Ophthalmology, University of Amsterdam,
Amsterdam, Netherlands *CR
5809 — D0056 Results of long-term silicone
oil tamponade for more than 12 months and
its complications. Yong Sok Ji, H. Jung, K. Yoon,
S. Park. Chonnam National University Hospital,
Gwangju, Republic of Korea
5810 — D0057 Temporal pattern of macular
thickness resolution and visual acuity
improvement after epiretinal membrane
peel surgeries. Ashley Campbell, D. Vavvas.
Ophthalmology, Massachusetts Eye and Ear,
Boston, MA *CR
Exhibit Hall D0071-D0078
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retina
519 Retina-RPE Transplantation
Moderators: Robert L. Avery and Susanne Binder
5811 — D0071 iPS-RPE implantation in the
Royal College of Surgeons Rat does not lead to
adverse events in a long term study of health and
graft stability. Stephen Bravo 1 , P. D. Westenskow 1 ,
T. Kurihara 1 , A. Dorsey 1 , L. Paris 1 , J. H. Lin 2 ,
M. Friedlander 1 . 1 Department of Cell Biology,
The Scripps Research Institute, La Jolla, CA;
2
Department of Pathology, UC San Diego School of
Medicine, La Jolla, CA
5812 — D0072 Development of a Novel Device
for Subretinal Transplantation Surgery of
Human iPSC-RPE Cell-Sheet. Hiroyuki Kamao 1, 2 ,
M. Mandai 1 , O. Mita 3 , Y. Harada 3 , J. Kiryu 2 , M.
Takahashi 1 . 1 Laboratory for Retinal Regeneration,
Riken Center for Developmental Biology, Kobe,
Japan; 2 Ophthalmology, Kawasaki Medical School,
Okayama, Japan; 3 Nidek inc., Gamagori, Japan *CR
5813 — D0073 Three-dimensional imaging
of developing photoreceptors transplanted in
a mouse model of CEP290-Leber congenital
amaurosis (LCA). Yi-Sheng Chang 1, 2 , R. Fariss 2 ,
C. Lin 2 , J. Nakamura 2 , W. McIntosh Ambrose 2 ,
K. Homma 2 , R. A. Rachel 2 , A. V. Cideciyan 3 ,
S. G. Jacobson 3 , A. Swaroop 2 . 1 Department of
Ophthalmology, National Cheng Kung University,
Tainan City, Taiwan; 2 National Eye Institute,
National Institutes of Health, Bethesda, MD;
3
Scheie Eye Institute, University of Pennsylvania,
Philadelphia, PA
5814 — D0074 Retinal Pigment Epithelium
- Choroid Transplantation: results up to 3
years. Laura Bertazzi 1 , A. Peroglio Deiro 1 , M. G.
Cereda 2 , G. Pertile 1 . 1 Ophthalmology, Ospedale
Sacro Cuore Don Calabria, Negrar, Verona, Italy;
2
Ophthalmology, Ospedale Sacco, Milano, Italy
5815 — D0075 The sodium iodate model
for transplantation of hESC-derived RPE.
Madalena Carido 1 , Y. Zhu 1 , B. Benkner 2 , T. Kurth 1 ,
T. A. Münch 2 , E. Tanaka 1 , M. Ader 1 . 1 Center for
Regenerative Therapies Dresden, DRESDEN,
Germany; 2 Werner Reichardt Centre for Integrative
Neuroscience, Tubingen, Germany
5816 — D0076 Transplantation of CD73-sorted
photoreceptor precursors into the rat retina. Kai
Postel, T. Santos-Ferreira, M. Ader. DFG-Center
for Regenerative Therapies Dresden, Technische
Universität Dresden, Dresden, Germany
5817 — D0077 Cone-like photoreceptor
transplantation into the mouse retina. Tiago
Santos-Ferreira, K. Postel, M. Ader. AG Ader,
DFG-Center for Regenerative Therapies Dresden,
Technische Universität Dresden, Dresden, Germany
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
366

Thursday – Posters – 5818 – 5838
5818 — D0078 Development of an ex-vivo
retinal explant model to assess transplantation
efficiency of photoreceptor progenitor cells.
Anat Yanai, C. R. Laver, A. E. Bashar, A. Metcalfe,
K. Gregory-Evans. Ophthalmology and Visual
Sciences, University of British Columbia,
Vancouver, BC, Canada
5823 — D0134 Pigment Migration
Distribution in Eyes with Non-neovascular
Age-Related Macular Degeneration. Yanling
Ouyang 1, 2 , F. M. Heussen 1, 2 , A. C. Walsh 2 , A. M.
Joussen 1 , S. R. Sadda 2 . 1 Ophthalmology, Charité-
Universitätsmedizin Berlin, Berlin, Germany;
2
Ophthalmology, Doheny Eye Institute, Los
Angeles, CA *CR
5824 — D0135 Acute zonal occult outer
retinopathy: A new classification based on
multimodal imaging. Samira Khan, L. M. Jampol.
Ophthalmology, Northwestern Univeristy, Chicago,
IL *CR
5825 — D0136 Retinal Morphology Changes
After Epiretinal Membrane Peeling. Judy E.
Kim 1 , N. R. Mathews 1 , S. Tarima 2 . 1 Department of
Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI; 2 Department of Biostatistics,
Medical College of Wisconsin, Milwaukee, WI
5826 — D0137 Comparison of a widefield
Polarization-sensitive OCT with standard
imaging of Geographic atrophy. Philipp K.
Roberts 1, 2 , S. Zotter 2 , B. Baumann 2 , M. Bolz 1 ,
C. G. Kiss 1 , R. G. Sayegh 1 , M. Baratsits 1 , M.
Pircher 2 , C. K. Hitzenberger 2 , U. Schmidt-Erfurth 1 .
1
Ophthalmology and Optometry, Medical University
of Vienna, Vienna, Austria; 2 Center for Medical
Physics And Biomedical Engineering, Medical
University of Vienna, Vienna, Austria *CR
5831 — D0142 Long-term progression, cystoid
macular edema and secondary epiretinal
membranes in severe chloroquine retinopathy.
Simone Kellner 1, 2 , S. Weinitz 1, 2 , G. Farmand 1 ,
U. Kellner 1, 2 . 1 Rare Retinal Disease Center,
AugenZentrum Siegburg, MVZ ADTC Siegburg
GmbH, Siegburg, Germany; 2 RetinaScience, Bonn,
Germany
5832 — D0143 Reading Center Evaluation
of Retinal Vein Occlusion Using Wide-field
Angiography. Eric Brinton 1 , A. Domalpally 2 , B. A.
Blodi 1, 2 . 1 Ophthalmology, University of Wisconsin,
Madison, WI; 2 Ophthalmology, Fundus Photograph
Reading Center, Madison, WI
5833 — D0144 Characterization of Ultrawidefield
Fundus Autofluorescence Patterns
in Retinal Dystrophies. George Trichonas, E. I.
Traboulsi, J. P. Ehlers. Ophthalmology, Cleveland
Clinic, Cleveland, OH *CR
Exhibit Hall D0130-D0184
Thursday, May 09, 2013 8:30 AM-10:15 AM
Retina
520 Imaging II, RE
Moderators: Michael D. Abramoff and
Stephen H. Tsang
5819 — D0130 The Papillomacular Fold in
Posterior Microphthalmos: New Insights Based
on Novel Spectral-Domain Optical Coherence
Tomography Findings. Sawsan R. Nowilaty 1 , A.
Mousa 2 , N. G. Ghazi 1 . 1 Vitreoretinal Division, King
Khaled Eye Specialist Hospital, Riyadh, Saudi
Arabia; 2 Department of Ophthalmology, King Saud
University, Riyadh, Saudi Arabia
5820 — D0131 The Use of PolyChromatic
Angiography for the Assessment of the Effects of
VEGF and Bevacizumab on the Rabbit Retina.
Samir R. Tari 1 , C. Samson 2 , U. B. Kompella 4 ,
R. L. Harris 3 , C. Lin 5 , D. A. Antonetti 5 , G. R.
Barile 6 . 1 PCAsso Diagnostics, North Brunswick,
NJ; 2 New York Eye and Ear Infirmary, New
York, NY; 3 Rutgers University, New Brunswick,
NJ; 4 University of Colorado Denver, Denver,
CO; 5 University of Michigan, Ann Arbor, MI;
6
Manhattan Eye Ear and Throat Hospital, New
York, NY *CR
5821 — D0132 In-vivo Imaging and
Measurement of the Bursa Premacularis using
1,050nm Swept-Source Deep Range Imaging
Optical Coherence Tomography (DRI-OCT1
Atlantis ® ). Silvestro Caputo 1 , A. Sala-Puigdollers 1 ,
H. Jaberansari 2 , J. Gray 1 , Y. D’Souza 1 , S. J.
Charles 1 , S. Biswas 1 , D. B. Henson 1, 3 , D. McLeod 1,
3
, P. E. Stanga 1, 3 . 1 Vitreoretinal Unit, Manchester
Royal Eye Hospital, Manchester, United Kingdom;
2
School of Medicine, University of Manchester,
Manchester, United Kingdom; 3 Manchester
Academic Health Science Centre and Centre for
Ophthalmology and Vision Research, Institute of
Human Development, University of Manchester,
Manchester, United Kingdom *CR
5822 — D0133 Choroidal Thickness in
Pseudoxanthoma Elasticum Measured by
Enhanced Depth Imaging Optical Coherence
Tomography. Martin Gliem, C. K. Brinkmann,
F. G. Holz, P. Charbel Issa. Department of
Ophthalmology, University of Bonn, Bonn,
Germany *CR
5827 — D0138 Detection of Fundus
Abnormalities in Diabetic Retinopathy using
Spectal Domain OCT versus Mydriatic
Color Fundus Imaging. Qing Shao 1 , Y.
Ouyang 1, 2 , F. M. Heussen 1, 2 , A. C. Walsh 2 , A.
M. Joussen 1 , S. R. Sadda 2 . 1 Ophthalmology,
Charité-Universitätsmedizin, Berlin, Germany;
2
Ophthalmology, Doheny Eye Institute - USC, Los
Angeles, CA *CR
5828 — D0139 Efficacy of NIR and SW-FAF
in resolved central serous chorioretinopathy:
Detecting outer retinal layer abnormality.
Seong-Woo Kim 1 , J. Oh 1 , S. Kim 1 , J. Oh 2 , C. Yun 1 ,
K. Huh 1 . 1 Ophthalmology, Korea University,
College of Medicine, Seoul, Republic of Korea;
2
Ophthalmology, Dongguk University, Ilsan
Hospital, Goyang, Republic of Korea
5829 — D0140 A Comparison of Heidelberg
and Zeiss OCT Imaging in Common Laboratory
Animals: Retinal Cell Layer Definition and
Correlation to Histopathology. Margaret E.
Collins 1 , W. S. Culp 3 , K. Tenneson 2 , S. Wise 2 , M.
Vezina 2 . 1 Toxicology, Charles River, Reno, NV;
2
Ocular and Neuroscience, Charles River, Montreal,
QC, Canada; 3 Technical Operations, Charles River,
Reno, NV *CR
5830 — D0141 Retinal Arteriolar Dilation
to Flicker Light is Reduced with Repeated
Stimulation. Jonathan E. Noonan 1 , R. Man 1 , T. T.
Nguyen 1 , J. Wang 1, 2 , E. L. Lamoureux 1, 3 . 1 Centre
for Eye Research Australia, East Melbourne, VIC,
Australia; 2 Centre for Vision Research, Sydney,
NSW, Australia; 3 Singapore Eye Research Institute,
Singapore, Singapore
5834 — D0145 The Characterization of Retinal
Bestrophinopaties, and Pseudovitelliform
Dystrophies using Polarisation Sensitive Optical
Coherence Tomography. Gabor Deak 1 , M.
Ritter 1 , S. Zotter 2 , P. K. Roberts 1 , B. Baumann 2 , M.
Pircher 2 , C. K. Hitzenberger 2 , U. Schmidt-Erfurth 1 .
1
Department of Ophthalmology, Medical University
of Vienna, Vienna, Austria; 2 Center for Medical
Physics and Biomedical Engineering, Medical
University of Vienna, Vienna, Austria *CR
5835 — D0146 Choroidal Thickness after
Treatment of Uveal Melanoma with Plaque
Brachytherapy. Kavitha R. Sivaraman, C. C.
Chow, W. F. Mieler. Department of Ophthalmology,
University of Illinois Eye & Ear Infirmary, Chicago,
IL *CR
5836 — D0147 Choroidal and Retinal
Thickness in Patients Affected by Chronic
Posterior Uveitis. Luisa Pierro, M. Gagliardi, E.
Miserocchi, L. Iuliano, I. Bianchi, C. Del Turco, G.
Parrinello, G. Modorati, M. B. Parodi, F. Bandello.
Department of Ophthalmology, Vita-Salute
University, San Raffaele Scientific Institute, Milan,
Italy *CR
5837 — D0148 Loss of GCL in HIV positive
patients with low (< 100) nadir CD4 counts.
Frank D. Verbraak 1, 2 , N. Demirkaya 1 , M. D.
Abramoff 3 . 1 Ophthalmology, Univ of Amsterdam
Acad Med Ctr, Amsterdam, Netherlands;
2
Biomedical Engineering & Physics, Academic
Medical Center, Amsterdam, Netherlands;
3
University of Iowa, Iowa City, IA *CR
5838 — D0149 Long-term follow-up of fundus
autofluorescence and multi-spectral reflectance
imaging using ultra-widefield scanning laser
ophthalmoscopy in patients with different retinal
pathologies. Viola Graham, M. Fleckenstein,
K. Zilkens, S. Schmitz-Valckenberg, F. G. Holz.
Department of Ophthalmology, University of Bonn,
Bonn, Germany *CR
Thursday Posters
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
367

5839 – 5863 – Thursday – Posters
Thursday Posters
8:30 am – 10:15 am
5839 — D0150 Measuring drusen over time:
OCT vs. Fundus Photography. Giovanni Gregori 1 ,
C. A. Garcia Filho 1 , Z. Yehoshua 1 , R. Portella
Nunes 1 , W. J. Feuer 1 , S. R. Sadda 2 , P. J. Rosenfeld 1 .
1
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 2 Ophthalmology, Doheny Eye Institute -
USC, Los Angeles, FL *CR
5840 — D0151 Varicela Zoster virus and
Central serous retinopathy. Lukan P. Mishev,
A. Misheva, I. Misheva, Y. Cankova, A. Angelov.
Ophthalmology, Focus Eye Center, Sofia, Bulgaria
5841 — D0152 Comparison of foveal central
thickness in using different spectral-domain
OCT machines with manual measurements.
Makoto Shirasawa, H. Terasaki, H. Kawano, T.
Yamashita, S. Sonoda, T. Sakamoto. Ophthalmology,
Kagoshima University, Kagoshima City, Japan
5842 — D0153 Optical coherence tomography
features in uveitic macular edema. Breno R.
Lima 1 , S. Mahesh 2 , H. Sen 1 . 1 National Eye Institute,
National Institutes of Health, Bethesda, MD; 2 Wills
Eye Institute, Philadelphia, PA
5843 — D0154 Posterior Eye Wall Radius
of Curvature as a Measure of Staphyloma
Progression in Myopic Foveoschisis Patients
as Gauged by Optical Coherence Tomography.
Pamela Sherwood 1 , J. Leong 1 , S. Chang 1 , G.
C. Cheung 2 , Q. V. Hoang 1 . 1 Ophthalmology,
Columbia University Medical Center, New York,
NY; 2 Singapore National Eye Centre, Singapore,
Singapore *CR
5844 — D0155 Evaluation of the Digital Light
Projector Camera (DLP-Cam) for Low-Cost
Diabetic Retinopathy Screening. Taras V. Litvin 1 ,
G. Y. Ozawa 1 , J. A. Cuadros 1 , M. S. Muller 3 , A. E.
Elsner 2, 3 , T. Gast 3 , J. Clendenon 3 , L. Ensman 2 , T.
Roy 1 , D. Li 1 . 1 School of Optometry, UC Berkeley,
Berkeley, CA; 2 School of Optometry, Indiana
University, Bloomington, IN; 3 Aeon Imaging, LLC,
Bloomington, IN *CR
5845 — D0156 Ultra-widefield retinal imaging
documentation and analysis of peripheral retinal
disease in Marfan syndrome: From the Marfan
Eye Consortium of Chicago. Safa Rahmani 1, 2 ,
A. A. Fawzi 1 , A. T. Lyon 1, 2 , I. H. Maumenee 3 , M.
Mets 2 . 1 Northwestern University, Chicago, IL;
2
Lurie Children’s Hospital of Chicago, Chicago, IL;
3
Univeristy of Illinois at Chicago, Chicago, IL
5846 — D0157 Intravitreal Injection of
Bevacizumab for Macula Edema Secondary to
Central Retinal Vein Occlusion: Efficacy at 1
Day after Injection. Atsushi Ishikawa, Y. Imamura,
M. Mita-Takahashi, R. Higashida, Y. Tsutsumi, Y.
Ichikawa, M. Ishida. Teikyo University, Kawasaki,
Japan
5847 — D0158 Fundus Autofluorescence of
Exudative Age-Related Macular Degeneration
with Intraretinal Cystoid Lesion. Tetsuya
Yamagishi 1 , H. Koizumi 2 , T. Yamazaki 1 , N. Terao 1 ,
K. Nakayama 1 , S. Kinoshita 1 . 1 Department of
Ophthalmology, Kyoto Prefectural Univ of Med,
Kyoto, Japan; 2 Department of Ophthalmology,
Tokyo Women’s Medical University, Tokyo, Japan
*CR
5848 — D0159 Retinal vascular abnormalities
in the far periphery of pathologic myopic
eyes imaged by ultra wide-field fluorescein
angiography. Yuichiro Kaneko 1 , M. Moriyama 1 , N.
Shimada 1 , N. Nagaoka 1 , K. Shinohara 1 , Y. Tanaka 1 ,
K. Ohno-Matsui 1 , T. Tokoro 1 , S. Hirahara 2 , Y.
Ogura 2 . 1 Ophthalmology & Visual Science, Tokyo
Medical and Dental University Graduate School of
Medicine and Dental Sciences, Bunkyo-ku, Japan;
2
Ophthalmology & Visual Science, Nagoya City
University Graduate School of Medical Scinences,
Nagoya, Japan
5849 — D0160 Retinal-choroidal changes
after loading phase of ranibizumab in diabetic
macular edema. Paola Giorno, M. Parravano, A.
Cacciamani, F. Oddone, F. Scarinci, A. Boninfante,
M. Varano. Ophthalmology, Fondazione G.B.
Bietti-IRCCS, Rome, Italy
5850 — D0161 Refractive Impact on the
Espion Multifocal ERG in Clinical Practice.
John Hamilton, A. M. Theogene, R. Munger, S. G.
Coupland. Ophthalmology, University of Ottawa
Eye Institute, Ottawa, ON, Canada *CR
5851 — D0162 Macular and Optic Nerve
Optical Coherence Tomography in Marfan
Patients: from the Marfan Eye Consortium of
Chicago. WanWan Xu 1 , S. Kurup 2 , A. A. Fawzi 1 ,
M. K. Durbin 4 , I. H. Maumenee 3 , M. Mets 2, 1 .
1
Ophthalmology, Northwestern University,
Chicago, IL; 2 Ophthalmology, Ann & Robert H.
Lurie Children’s Hospital of Chicago, Chicago, IL;
3
Ophthalmology and Visual Sciences, University
of Illinois at Chicago, Chicago, IL; 4 Carl Zeiss
Meditec, Inc, Dublin, CA *CR
5852 — D0163 Multimodal imaging in
Persistent Placoid Maculopathy. Mohamed
G. Gendy 1 , A. A. Fawzi 1 , R. T. Wendel 2 , D. J.
Pieramici 3 , J. A. Miller 4 , D. M. Brown 5 , L. M.
Jampol 1 . 1 Ophthalmology, Northwestern University,
Chicago, IL; 2 Retina Consultants, Sacramento, CA;
3
California Retina Consultants, Bakersfield, CA;
4
Retina Consultants of Michigan, Southfield, MI;
5
Retina Consultants of Houston, Houston, TX *CR
5853 — D0164 Novel angiographic findings
in Susac syndrome identified by ultra-widefield
imaging technology. Priyanka Kumar, R. J.
Courtney, K. Baynes, C. Y. Lowder, J. P. Ehlers, R.
Rennebohm, S. K. Srivastava. Cole Eye Institute,
Cleveland Clinic Foundation, Cleveland, OH *CR
5854 — D0165 Development of a Premacular
Vitreous Pocket. Tadashi Yokoi, N. Azuma.
Ophthalmology, National Center for Child Health
and Development, Tokyo, Japan
5855 — D0166 Evaluation of subfoveal
choroidal thickness before and after cataract
surgery. Minoru Tanigawa, Y. Shimada, Y. Ochiai,
H. Ochiai, Y. Tsukahara, H. Yamanaka. Shin-
Nagata Eye Institute, Kobe, Japan
5856 — D0167 Classification and Quantitative
Analysis of Geographic Atrophy Lesions
Using Spectral-Domain Optical Coherence
Tomography. Jinfeng Qu 1, 2 , M. Nittala 2 , A. Hariri 2 ,
D. M. Wu 2 , S. Sadda 2 . 1 Ophthalmology, People’s
Hospital of Peking University, Beijing, China;
2
Doheny Image Reading Center, Doheny Eye
Institute, Los Angeles, CA *CR
5857 — D0168 Spectral-Domain Optical
Coherence Tomography Findings of Eyes With
Idiopathic Macular Telangiectasia. Mounir
Benzerroug, S. Molva, D. Bremond-Gignac, S.
Milazzo. Ophthalmology, Amiens University
Hospital, Amiens, France
5858 — D0169 Assessing IOLMaster
Measurement of Eye Axial Length in Pathologic
Myopia Patients with Staphyloma. Jamie
Leong, R. H. Silverman, S. Chang, Q. V. Hoang.
Ophthalmology, Columbia University, New York,
NY *CR
5859 — D0170 Is the Integrity of the
Photoreceptor Layer A Prognostic Factor for
Visual Acuity Gain in Thick Macular Puckers?
Aranzazu Mateo Montoya 1 , B. Wolff 1 , V. Martinet 1 ,
P. Cornut 2 , J. A. Sahel 1 . 1 Retina, Fondation
Ophtalmologique Adolphe de Rothschild, Paris,
France; 2 Hôpital Edouard Herriot, Lyon, France
*CR
5860 — D0171 Cyst Size Does Not Predict
Response to Therapy on OCT Imaging of
Macular Edema. Gautam Kamthan, R. M.
Lieberman. Mount Sinai School of Medicine, New
York, NY
5861 — D0172 Photoreceptor Changes
on Multi-Modal Adaptive-Optics Imaging
Correlate with Transient Abnormalities on
Autofluorescence and Indocyanine Green
Angiography in a Patient with Multiple
Evanescent White Dot Syndrome. John E.
Legarreta 1 , A. D. Legarreta 1, 2 , Z. Nadler 1 , L. T.
Labriola 1 . 1 Ophthalmology, UPMC Eye Center/
University of Pittsburgh, Pittsburgh, PA; 2 Duke
University, Durham, NC
5862 — D0173 Unique Features of Choroidal
Vasculature In Patients with Choroidal
Neovascular Membranes. Swetangi D. Bhaleeya,
D. J. D’Amico, S. Kiss. Ophthalmology, Weill
Cornell Medical Center, New York City, NY *CR
5863 — D0174 Choroidal thickness
after treatment of chronic central serous
chorioretinopathy: half-fluence photodynamic
therapy versus intravitreal injection of
bevacizumab. Yong Un Shin, B. Lee, D. Lee.
Ophthalmology, Hanyang University Medical
Center, Seoul, Republic of Korea *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
368

Thursday – Posters – 5864 – 5887
5864 — D0175 Steroid-associated central
serous chorioretinopathy, multidisciplinary
imaging. Byung Ro Lee, Y. Shin, S. Lee.
Ophthalmology, Hanyang Univ Hosp, Seoul,
Republic of Korea *CR
5865 — D0176 Progression of Atrophy of
the Retinal Pigment Epithelium in Stargardt
Macular Dystrophy on Fundus Autofluorescence
Imaging. Emily Fletcher 1, 2 , Y. Wolfson 1 , B. E.
Munoz 1 , H. P. Scholl 1, 3 . 1 Ophthalmology, Johns
Hopkins University, Baltimore, MD; 2 Retina
Division, Gloucester Royal Hospital, Gloucester,
United Kingdom; 3 Ophthalmology, Medical
University Graz, Graz, Austria
5866 — D0177 Macular Choroidal Thickness
Evaluation By SD OCT In Patients Affected
By Retinal Vein Occlusion. Davide Borroni, E.
Melardi, C. Gandolfi, M. Al Oum, S. Donati, M.
Chiaravalli, C. Azzolini. Department of Surgical
and Morphological Sciences, University of
Insubria-Circolo Hospital, Varese, Italy
5867 — D0178 The Dissociation Between the
Ganglion Cell Analysis/Ganglion Cell Complex
and Peripapillary Retinal Nerve Fiber Layer
Thickness in Hereditary Retinal Disease. Sherry
J. Bass, A. Wong, J. Sherman. Clinical Sciences,
SUNY College of Optometry, New York, NY *CR
5868 — D0179 Myopia Progression
Accompanying with Myopic Disc Change at the
Convalescent Stage of Vogt-Koyanagi-Harada
Disease. Hiroyuki Takahashi, H. Takase, N.
Shimada, K. Ohno-Matsui, M. Mochizuki. Ophthal
& Visual Science, Tokyo Medical and Dental Univ,
Bukyo-ku, Japan *CR
5869 — D0180 Novel and safe technique for
smartphone fundus photography: Application
in human and animal eyes. Luis J. Haddock 1 , D.
Kim 1 , F. C. Delori 2 , S. Mukai 1 . 1 Ophthalmology,
Massachusetts Eye and Ear Infirmary, Boston, MA;
2
Ophthalmology, Schepens Eye Research Institute,
Boston, MA
5870 — D0181 Comparing Optos OTI and
Heidelberg Spectralis SD-OCT in Patients with
Diabetic Macular Edema. Samia Fatum, M.
Sinczak, A. Sachdev, V. Chong. Ophthalmology,
Oxford University Hospitals NHS Trust, Oxford,
United Kingdom *CR
5871 — D0182 Improving the Analysis
of Choroidal Laser Doppler Flowmetry
Measurements; Application in Patients with
Retinal Diseases. Nattapon Boonarpha 1, 2 , G.
Czanner 1, 3 , A. Raj 1, 2 , Y. Zheng 1, 2 , M. Geiser 4 , C. E.
Riva 5 , J. Sahni 1, 2 , S. P. Harding 1, 2 . 1 Department of
Eye and Vision Science, University of Liverpool,
Liverpool, United Kingdom; 2 St. Paul’s Eye Unit,
Royal Liverpool University Hospital, Liverpool,
United Kingdom; 3 Department of Biostatistics,
University of Liverpool, Liverpool, United
Kingdom; 4 University of Applied Sciences of
Western Switzerland, Sion, Switzerland; 5 Medical
School, University of Lausanne, Lausanne,
Switzerland *CR
5872 — D0183 Ultra-wide field fluorescein
angiography in patients with diabetic
retinopathy. Taneto Tomiyasu, S. Hirahara, M.
Yoshida, M. Nozaki, Y. Ogura. Opthalmology,
Nagoya City Univ Medical School, Nagoya, Japan
5873 — D0184 Repeatability and
Reproducibility of Spectral-domain Optical
Coherence Tomography in Measurement of
Retinal Thickness in Rats. TaeGi Kim, J. Yang, J.
Han, S. Yu, H. Kwak. Ophthalmology, Kyung Hee
University Hospital, Seoul, Republic of Korea
Exhibit Hall D0237-D0262
Thursday, May 09, 2013 8:30 AM-10:15 AM
Anatomy/Pathology
521 Ocular and Orbital Tumors
Moderators: Seymour Brownstein and
Valerie A. White
5874 — D0237 Malignant Cancer After
Trauma or Presumed Trauma in Cats. Richard R.
Dubielzig. Pathobiol Sciences, Univ of Wisconsin-
Madison, Madison, WI *CR
5875 — D0238 Canine Primary Ocular
Osteosarcomas and Chondrosarcomas. Felicia
D. Duke, R. R. Dubielzig. Pathobiological Sciences,
University of Wisconsin, Madison, WI *CR
5876 — D0239 AJCC TNM Collaborative
Internet Staging Validation For Ophthalmic
Tumors. Priya Selvakumar. 1 The Ophthalmic
Oncology Task Force, American Joint Committee
on Cancer, Chicago, IL; 2 Health Informatics
Research, Princess Margaret Cancer Centre,
Toronto, ON, Canada
5877 — D0240 Prognostic Factors Associated
with Histopathology in Intraocular and Ocular
Adnexal Lymphoma: A Twenty Years Review for
the University of Wisconsin Madison. Pimkwan
Jaru-ampornpan 1 , A. Azari 1 , M. Rezaei Kanavi 1, 2 ,
H. Potter 1 , D. M. Albert 1 . 1 Ophthalmology and
Visual Sciences, University of Wisconsin, Madison,
Madison, WI; 2 Ophthalmic Research Center, Shahid
Beheshti University of Medical Sciences, Tehran,
Islamic Republic of Iran
5878 — D0241 Uveal Lymphoma: Comparison
of Diagnostic Imaging Studies. Mary E. Aronow 1 ,
C. Portell 2 , J. Sweetenham 2 , A. D. Singh 1 . 1 Cole
Eye Institute, Cleveland Clinic, Shaker Heights,
OH; 2 Hematologic Oncology and Blood Disorders,
Cleveland Clinic, Taussig Cancer Institute,
Cleveland, OH
5879 — D0242 Clinical and epidemiologyc
features of lymphoproliferative lesions in the
orbital and adnexal region at the Asociación
Para Evitar la Ceguera en México. Linda Guakil 1 ,
G. Salcedo 1 , A. A. Rodríguez-Reyes 2 , R. Rubio 1 .
1
Orbit and Oculoplastics, Asociacion Para Evitar La
Ceguera En Mexico, Mexico, Mexico; 2 Pathology,
Asociacion Para Evitar La Ceguera En Mexico,
Mexico, Mexico
5880 — D0243 The Usefulness of Cell
Block Technique in Cytological diagnosis of
Primary Intraocular Lymphoma. Takako Ito 1 ,
H. Yoshikawa 1 , A. Takeda 1 , T. Yoshimura 1 , S.
Hirakawa 1 , K. Sonoda 2 , T. Koga 3 , T. Ishibashi 1 .
1
Ophthalmology, Kyushu University, Fukuoka,
Japan; 2 Ophthalmology, Yamaguchi University,
Yamaguchi, Japan; 3 Pathology, Kyushu University,
Fukuoka, Japan
5881 — D0244 Distinct Profiles of Vitreous
micro RNA in Primary Vitreoretinal Lymphoma
and Uveitis. Jingsheng Tuo, D. Shen, C. Chan.
Laboratory of Immunology, National Eye Institute/
NIH, Rockville, MD
5882 — D0245 Using a Murine Xenograft
Model for Von Hippel-Lindau Disease-Associated
Retinal Hemangioblastomas to Test Novel
Therapies. Stanley Park 1, 2 , Y. Wang 1 , K. Huntoon 3 ,
D. Shen 1 , Z. Zhuang 3 , C. Chan 1 . 1 Immunopathology
Section, Laboratory of Immunology, NEI, NIH,
Bethesda, MD; 2 Howard Hughes Medical Institute,
Chevy Chase, MD; 3 Surgical Branch, NINDS, NIH,
Bethesda, MD
5883 — D0246 Transvitreal endoresection of
retinal hemangioblastoma after ligating feeder
vessels. Gibran S. Khurshid. Ophthal & Visual Sci,
Univ of Texas Medical Branch, Galveston, TX
5884 — D0247 Prognostic Factors after
Treatment of Patients with Retinal Capillary
Hemangioma(RCH). Hyesun Kim, J. Yi, H. Kwon,
C. S. Lee, S. lee. Department of Ophthalmology,
Yonsei University Severance Hospital, Seoul,
Republic of Korea
5885 — D0248 Safety and Efficacy
of Anti-VEGF Therapy for Choroidal
Neovascularization Overlying Choroidal
Osteoma. Mohammed A. Khan 1 , F. C. DeCroos 2 ,
P. P. Storey 2 , J. Shields 3 , S. J. Garg 2 , C. L. Shields 3 .
1
Ophthalmology, Wills Eye Institute, Philadelphia,
PA; 2 Retina Service, Wills Eye Institute,
Philadelphia, PA; 3 Oncology Service, Wills Eye
Institute, Philadelphia, PA *CR
5886 — D0249 Effect of menopausal status
on the progression of orbital cavernous
hemangiomas. Anupam Jayaram, G. Lissner.
Ophthalmology, Northwestern University, Chicago,
IL
5887 — D0250 The effect of Transforming
growth factor-beta-induced protein (TGFBIp)
in lymphangiogenesis. Yong-Sun Maeng, T. Kim,
H. Lee, E. Kim. Ophthalmology, Yonsei University,
Seoul, Republic of Korea
Thursday Posters
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
369

5888 – 5905 – Thursday – Posters
Thursday Posters
8:30 am – 10:15 am
5888 — D0251 RAS Mutations Coexist with
PIK3CA and MET Mutations in Lacrimal
Gland Epithelial Neoplasms. Bita Esmaeli 1 , V. T.
Yin 1 , K. Wani 2 , K. Aldape 2 , D. Bell 2 . 1 Head & Neck
Surgery/Ophthal, UT MD Anderson Cancer Center,
Houston, TX; 2 Pathology, UT MD Anderson Cancer
Center, Houston, TX
5889 — D0252 Screening of Optic Pathway
Gliomas in Children with Neurofibromatosis
Type-1. Raffaele Parrozzani 1 , M. Clementi 2 ,
G. Orlando 3 , G. Miglionico 3 , E. Trevisson 2 , E.
Midena 3, 1 . 1 GB Bietti Eye Foundation, IRCCS,
Rome, Italy; 2 Department of Pediatrics, Clinical
Genetics, University of Padova, Padova, Italy;
3
Department of Ophthalmology, University of
Padova, Padova, Italy
5890 — D0253 Association of AJCC pT
category with outcome in sebaceous carcinoma
of the eyelid. Valerie A. White 1, 2 , K. Mulay 3 ,
S. Agrawal 4 , S. Honavar 4 . 1 Department of
Pathology and Laboratory Medicine, University
of British Columbia, Vancouver, BC, Canada;
2
Ophthalmology and Visual Science, University
of British Columbia, Vancouver, BC, Canada;
3
Ophthalmic Pathology, LV Prasad Eye Institute,
Hyderabad, India; 4 Oculoplastic and Orbital
Surgery, LV Prasad Eye Institute, Hyderabad, India
5891 — D0254 Stratifin- A novel biomarker
in the prognosis of Ocular Surface Squamous
Neoplasia patients. Sheetal Chauhan 1 , S. Sen 1 , A.
Sharma 2 , S. Kashyap 1 , S. S. Chauhan 3 , R. Tandon 4 ,
N. Pushker 4 , M. Vanathi 4 , R. Azad 4 . 1 Ocular
Pathology, R.P.Centre, All India Institute of Medical
Sciences, New Delhi, India; 2 Ocular Microbiology,
All India Institute of Medical Sciences, New Delhi,
India; 3 Biochemistry, All India Institute of Medical
Sciences, New Delhi, India; 4 Ophthalmology, All
India Institute of Medical Sciences, New Delhi,
India
5892 — D0255 Incidence and immunostaining
pattern of oncocytomas of the caruncle - a single
center 12 year analysis. Sandra C. Bajorat 1 ,
M. von Schoenfels 1 , I. Leuschner 2 , J. Roider 1 ,
S. O. Koinzer 1 . 1 Ophthalmology, University of
Kiel, University Medical Center, Kiel, Germany;
2
Pathology, University of Kiel, University Medical
Center, Kiel, Germany *CR
5893 — D0256 Classification Schemes for
Conjunctival Melanocytic Neoplasia: the
Effect of Immunohistochemistry on C-MIN
Scoring. Emilia H. DeMarchis 1 , P. Egbert 2 , J.
Kim 3, 4 . 1 School of Medicine, Stanford University,
Palo Alto, CA; 2 Department of Ophthalmology,
Stanford University, Stanford, CA; 3 Department
of Pathology, Stanford University, Stanford, CA;
4
Department of Dermatology, Stanford University,
Stanford, CA
5894 — D0257 Immunohistochemical
Analysis with a Novel Red Chromagen of
Benign and Malignant Melanocytic Lesions
of the Conjunctiva. Seymour Brownstein 1, 2 ,
K. Jiang 1, 2 , K. Lam 1, 2 , B. F. Burns 2 , J. Farmer 2 .
1
Ophthalmology, Ottawa Hospital, Ottawa, ON,
Canada; 2 Pathology, Ottawa Hospital, Ottawa, ON,
Canada
5895 — D0258 Conjunctival Nevus:
Clinicopathological Review of 724 cases.
Stephanie De la O-Pérez 1 , H. A. Rodríguez-
Martínez 2 , D. Ríos y Valles-Valles 1 , O. Pérez-
Olvera 2 , A. Gómez-Leal 1 , A. Medina-Cruz 2 , M.
Y. Namba-Bando 1 , L. H. De La O-Cerna 3 , A. A.
Rodríguez-Reyes 1 . 1 Ophthalmic Pathology Service,
Hospital “Dr. Luis Sánchez Bulnes”, Asociación
Para Evitar la Ceguera en México, Mexico
city, Mexico; 2 Anatomopathological Research
Laboratory “Roberto Ruiz Obregón” Experimental
Medicine Department, Medical Faculty, National
Autonomous University of Mexico, General
Hospital of Mexico, Mexico City, Mexico; 3 Eye
Bank, University Hospital, Autonomous University
of Coahuila, Torreón, Mexico
5896 — D0259 The Growth of Small
Choroidal Melanocytic Lesion after Intravitreal
Bevacizumab Injection. Hee Jung Kwon, H. Kang,
H. Kim, S. Lee, C. S. Lee. Ophthalmology, Institute
of Vision Research, Yonsei University College of
Medicine, Seoul, Republic of Korea
5897 — D0260 Clinical utility of SD-OCT
-Enhanced Depth Imaging in Evaluation of
Retinal and Choroidal Tumors of the Human
Eye. Peter G. Hovland. Colorado Retina Associates,
Denver, CO
5898 — D0261 Waardenburg Syndrome:
Iris and Choroidal Hypopigmentation findings
on Anterior and Posterior Segment Imaging.
Stephanie Nickerson, C. L. Shields, S. AL-Dahmash,
J. Shields. Ocular Oncology Service, Wills Eye
Institute, Philadelphia, PA
5899 — D0262 Does beta-ray emitting
therapy of ciliary body tumors decrease central
corneal endothelial cell density? Eva Suranyi 1 ,
A. Berta 2 , L. Modis 3 , E. Szalai 4 , J. Damjanovich 5 .
1
Ophthalmology, University of Debrecen, Debrecen,
Hungary; 2 Ophthalmology, University of Debrecen,
Debrecen, Hungary; 3 Ophthalmology, University
of Debrecen, Debrecen, Hungary; 4 Ophthalmology,
University of Debrecen, Debrecen, Hungary;
5
Ophthalmology, University of Debrecen, Debrecen,
Hungary
Exhibit Hall D0263-D0276
Thursday, May 09, 2013 8:30 AM-10:15 AM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
522 Thyroid Eye Disease
Moderator: Huibert J. Simonsz
5900 — D0263 Signal intensity measurement
of magnetic resonance imaging for
extraocular muscles inflammation in thyroidassociated
ophthalmopathy before and after
methylprednisolone pulse therapy. Tomoaki
Higashiyama, Y. Nishida, Y. Ichiyama, S. Muraki,
M. Ohji. Ophthalmology, Shiga University of
Medical Science, Otsu, Japan *CR
5901 — D0264 Subclinical alterations of
extraocular muscles in Graves’ Disease. Alberto
Cuccu 1 , I. Zucca 1 , M. Galantuomo 1 , S. Mariotti 2 , F.
Boi 2 , R. Vacca 2 , M. Fossarello 1 . 1 Ophthalmology,
University of Cagliari, Cagliari, Italy; 2 Medical
Science, University of Cagliari, Cagliari, Italy
5902 — D0265 Medical Histories and
Ophthalmic Features, including Orbital Images
of MRI, in Patients with Dysthyroid Optic
Neuropathy. Ai Kozaki, T. Inoue, C. Funaki,
K. Mizuno, R. Inoue, Y. Inoue. Ophthalmology,
Olympia Eye Hospital, Tokyo, Japan
5903 — D0266 Protocol for Protein Isolation
from Human Orbital Fat Tissue: Use for Western
Blots and Antigen Biomarker Identification in
Thyroid Eye Disease. Katie Mills 1 , M. Z. Radic 2 ,
I. Neeli 2 , M. E. Phillips 1 , C. Cutler Peck 1 , B. N.
Wilkes 1 , J. C. Fleming 1 , A. Iannaccone 1 , N. C.
Kerr 1 . 1 Ophthalmology, Hamilton Eye Institute,
Memphis, TN; 2 Molecular Science, University of
TN, Memphis, TN
5904 — D0267 Palmitate induced secretion
of IL-6 and MCP-1 in orbital fibroblasts
derived from patients with thyroid-associated
ophthalmopathy. Ji-Sun Paik 1 , W. Cho 2 , E. Oh 3,
4
, S. Lee 3, 4 , S. Yang 1 . 1 Ophthalmology and Visual
Science, Seoul St. Mary’s Hospital, The Catholic
University of Korea, Seoul, Republic of Korea;
2
Ophthalmology and Visual Science, DaeJeon St.
Mary’s Hospital, the Catholic University of Korea,
Seoul, Republic of Korea; 3 Institue of Hansen’s
Disease, College of Medicine, the Catholic
University of Korea, Seoul, Republic of Korea;
4
Pathology, College of Medicine, the Catholic
University of Korea, Seoul, Republic of Korea
5905 — D0268 Treatment of Esotropia
from Thyroid Eye Disease by Lateral Rectus
Resection. Daniel Greninger, P. H. Berg, E. A.
Steele. Ophthalmology, Oregon Health and Science
University, Portland, OR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
370

Thursday – Posters – 5906 – 5913
5906 — D0269 Lower Social Grade and Higher
Social Deprivation are Independently Associated
with Severe Thyroid Eye Disease. Matthew R.
Edmunds 1, 2 , J. A. Huntbach 2 , O. M. Durrani 2 .
1
Academic Unit of Ophthalmology, University
of Birmingham, Birmingham, United Kingdom;
2
Birmingham & Midland Eye Centre, Birmingham,
United Kingdom
5907 — D0270 Rapamycin enhances the
TNF-α-induced secretion of IL-6 and IL-8 by
suppressing PDCD4 degradation in orbital
fibroblasts. Won-Mo Lee 1 , J. Won 2 , J. Paik 2 ,
W. Cho 2 , E. Oh 3, 4 , S. Lee 3, 4 , S. Yang 2 . 1 Seong-
Mo Eye Clinic, Dae Jeon, Republic of Korea;
2
Ophthalmology and Visual Science, the Catholic
University of Korea, Seoul, Republic of Korea;
3
Institute of Hansen’s Disease, The Catholic
University of Korea, Seoul, Republic of Korea;
4
Department of Pathology, The Catholic University
of Korea, Seoul, Republic of Korea
5908 — D0271 Readability Assessment of
Online Thyroid Eye Disease Patient Information.
Alastair K. Denniston 1, 2 , M. R. Edmunds 1, 2 .
1
Academic Unit of Ophthalmology, University
of Birmingham, Birmingham, United Kingdom;
2
University Hospitals Birmingham NHS Foundation
Trust, Birmingham, United Kingdom
5909 — D0272 Clinical and Biochemical
Characteristics of Thyroid-Associated
Ophthalmopathy in Korean Populations using
VISA and Fat/Muscle Typing. Young Ji Lee 1 ,
S. Lee 1 , H. Lew 2 , J. Yoon 1 . 1 Institute of Vision
Research, Department of Ophthalmology, Yonsei
University College Of Medicine, Seoul, Republic
of Korea; 2 Department of Ophthalmology, CHA
University, Bundang CHA Medical Center,
Sungnam, Republic of Korea
5910 — D0273 Clinical Features of
Japanese Elderly Patients with Dysthyroid
Ophthalmopathy. Kahori Mizuno, A. Kozaki, C.
Funaki, G. Ito, R. Inoue, K. Nishiyama, T. Inoue,
Y. Inoue. Ophthalmology, Olympia Eye Hospital,
Tokyo, Japan
5911 — D0274 Thyroid Eye Disease With
Compressive Optic Neuropathy: Decompression
Versus Radiation. Sheila Goyal, M. A. Slabaugh, S.
Chang. Ophthalmology, University of Washington,
Seattle, WA
5912 — D0275 Expression of GRα mRNA and
NF-kB in orbital fat and extraocular muscle
in Thyroid Eye Disease. Ivana L. Romero-
Kusabara 1, 3 , A. N. Cury 2, 3 , J. Vital Filho 1 , N. M.
Scalissi 2 , K. C. Melo 3 , G. Demartino 3 , C. A. Longui 2,
3
, M. R. Melo 3 . 1 Ophthalmology, Santa Casa of Sao
Paulo, Sao Paulo, Brazil; 2 Endocrinology, Santa
Casa of Sao Paulo, Sao Paulo, Brazil; 3 Molecular
Medicine Laboratoty, Physiology, Santa Casa of
Sao Paulo, Sao Paulo, Brazil
5913 — D0276 Posterior conjunctival plication
to correct secondary ptosis after eyelid retraction
repair in Graves disease. Vinita Srivastava 1 , H. R.
Patel 1 , H. A. Shah 1, 2 , H. H. Lee 1, 2 , W. R. Nunery 1, 3 .
1
Dept of Ophthalmology, Indiana University School
of Medicine, Indianapolis, IN; 2 Oculofacial Plastic
and Orbital surgery, Indianapolis, IN; 3 Oculofacial
Plastic and Orbital surgery, Louisville, KY
Thursday Posters
8:30 am – 10:15 am
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
371

5914 – 5929 – Thursday – Papers/Minisymposium
Thursday Papers/
Minisymposium
10:30 am – 12:15 pm
6B
Thursday, May 09, 2013 10:30 AM-12:15 PM
Glaucoma
523 Structure/Function
Moderator: Claude F. Burgoyne
5914 — 10:30 Relationships among Visual
Cortex Metabolism, Retinal Morphology
and Visual Function in Early and Advanced
Glaucoma. Kevin C. Chan 1, 2 , I. P. Conner 1 , Z.
Safiullah 2 , S. Kim 3, 2 , G. Wollstein 1 , J. S. Schuman 1, 2 .
1
UPMC Eye Center, Eye and Ear Institute,
Ophthalmology and Visual Science Research
Center, Department of Ophthalmology, University
of Pittsburgh, Pittsburgh, PA; 2 Department
of Bioengineering, University of Pittsburgh,
Pittsburgh, PA; 3 Department of Radiology,
University of Pittsburgh, Pittsburgh, PA *CR
5915 — 10:45 The relationship between cup/
disc ratio and estimated number of retinal
ganglion cells. Andrew J. Tatham 1 , R. N. Weinreb 1 ,
L. M. Zangwill 1 , J. M. Liebmann 2 , C. A. Girkin 3 ,
F. A. Medeiros 1 . 1 Hamilton Glaucoma Center,
University California San Diego, La Jolla, CA;
2
Department of Ophthalmology, New York Eye
and Ear Infirmary, New York, NY; 3 Department
of Ophthalmology, University of Alabama,
Birmingham, AL *CR, f
5916 — 11:00 Machine Classifier Clustering
of Ocular Structure Measurements Poorly
Corresponds with Longitudinal Functional
Performance in Glaucoma. Jessica E. Nevins 1 ,
D. Danks 2, 3 , G. Wollstein 1 , H. Ishikawa 1, 4 , L.
Kagemann 1, 4 , I. A. Sigal 1, 4 , J. S. Schuman 1, 4 .
1
UPMC Eye Center, Eye and Ear Institute,
Ophthalmology and Visual Science Research
Center, Department of Ophthalmology, University
of Pittsburgh, Pittsburgh, PA; 2 Department of
Philosophy, Carnegie Mellon University, Pittsburgh,
PA; 3 Institute for Human & Machine Cognition,
Pensacola, FL; 4 Department of Bioengineering,
Swanson School of Engineering, University of
Pittsburgh, Pittsburgh, PA *CR
5917 — 11:15 Posterior Lamina Cribrosa
Displacement at Different Stages of Glaucoma.
Sung Chul Park 1, 2 , R. L. Furlanetto 1 , C. F. Netto 1 ,
Y. Liu 1, 3 , Y. Kung 1, 3 , S. Fernando-Sieminski 4 , J.
M. Liebmann 1, 5 , R. Ritch 1, 2 . 1 Moise and Chella
Safra Advanced Ocular Imaging Laboratory,
Einhorn Clinical Research Center, New York Eye
and Ear Infirmary, New York, NY; 2 Department
of Ophthalmology, New York Medical College,
Valhalla, NY; 3 New York Medical College, New
York, NY; 4 Ross Eye Institute, State University of
New York at Buffalo, Buffalo, NY; 5 Department of
Ophthalmology, New York University School of
Medicine, New York, NY *CR
5918 — 11:30 Relating retinal ganglion cell
(RGC) function and retinal nerve fiber layer
(RNFL) retardance to progressive loss of RNFL
thickness (RNFLT). Brad Fortune, G. Cull, J.
Reynaud, C. F. Burgoyne. Discoveries in Sight
Research Laboratories, Devers Eye Institute and
Legacy Research Institute, Legacy Health, Portland,
OR *CR
5919 — 11:45 Why ISNT Rim Area Greater
for Superior Optic Disc? William H. Swanson 1 ,
V. Malinovsky 1 , M. W. Dul 2 . 1 School of Optometry,
Indiana University, Bloomington, IN; 2 SUNY
College of Optometry, State University of New
York, New York, NY
5920 — 12:00 Retinal venous pulsatility is
reduced in regions of nerve fibre layer loss
in glaucoma. Mojtaba Golzan 1 , W. Morgan 2 , S.
Graham 1 . 1 Macquarie University, Sydney, NSW,
Australia; 2 Lions Eye Institute, University of
Western Australia, Perth, NSW, Australia
6C
Thursday, May 09, 2013 10:30 AM-12:15 PM
Retina
524 Imaging: Diagnostic and Function
Moderators: Timothy W. Olsen and
David J. Wilson
5921 — 10:30 SD-OCT Progressive Alterations
in a Family Affected with Müller Cell Sheen
Dystrophy. Valentina Franco-Cardenas, J. Dalma-
Weiszhausz, R. E. Martinez-Munoz, A. Dalma.
Retina, Asociacion para Evitar la Ceguera en
Mexico, Mexico City, Mexico
5922 — 10:45 Outer Retina Analysis by
Optical Coherence Tomography in Cone-Rod
Dystrophy Patients. Luiz H. Lima 1 , J. M. Sallum 1 ,
R. F. Spaide 2 . 1 Ophthalmology, Federal Unive of
Sao Paulo-UNIFESP, Sao Paulo, Brazil; 2 Vitreous,
Retina, Macula Consultants of New York, New
York, NY *CR
5923 — 11:00 Atypical findings in Spectral
Domain Optical Coherence Tomography of
Ocular Toxoplasmosis with Active Lesions.
Florian M. Heussen, Y. Ouyang, Q. Shao, A. M.
Joussen, U. Pleyer. Ophthalmology, Charite -
University Medicine Berlin, Berlin, Germany *CR
5924 — 11:15 Short-term Spectral Domain
Optical Coherence Tomography Changes
after Phacoemulsification in Eyes with No
Pre-operative Macular Pathology. Yulia
Wolfson, W. Stark, S. B. Bressler, N. M. Bressler.
Ophthalmology, Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD *CR
5925 — 11:30 Macular vascular development
assessed by fluorescein angiography in
premature newborn patients with retinopathy
of prematurity. Alberto Hernandez-Vargas, G.
Salcedo-Villanueva, R. Romero Vera, S. Salinas
Longoria, F. Schoonewolff, V. Morales-Canton, J.
J. Fromow-Guerra, M. A. Martinez-Castellanos.
Assoc Para Evitar la Ceguera en Mexico, IAP,
Mexico, Mexico *CR
5926 — 11:45 Three-year multimodal imaging
and predictive value of retinal nerve fiber
layer axoplasmic debris in branch retinal
vein occlusion. Marion R. Munk 1 , S. Sacu 1 , R.
Dunavoelgyi 1 , M. Baratsits 1 , A. Montuoro 2 , G.
Matt 1 , C. G. Kiss 1 , W. Buehl 1 , U. Schmidt-Erfurth 1 .
1
Dept of Ophthalmology, Medical University
Vienna, Vienna, Austria; 2 Vienna Reading Center,
Medical University Vienna, Vienna, Austria *CR
5927 — 12:00 Assessment of the inner segment/
outer segment layer in patients with macular
edema due to central retinal vein occlusion.
Barbara A. Blodi, S. Chen, Y. Huang, J. W. Pak, A.
Domalpally. Department of Ophthalmology and
Visual Science, University of Wisconsin, Madison,
WI *CR
606/607
Thursday, May 09, 2013 10:30 AM-12:15 PM
Immunology/Microbiology
525 Clinical and Translational Studies
in Ocular Inflammation
Moderators: Andrew D. Dick and Justine R. Smith
5928 — 10:30 Targeted B-cell Therapy with
Rituximab for the Treatment of Autoimmune
Retinopathy: Results of a Pilot Clinical Trial.
H Nida Sen 1 , M. D. Dalal 1 , L. Grange 1 , Y. Wang 1 ,
J. R. Heckenlively 2 , P. R. Sherry 1 , C. Chan 1 , R.
B. Nussenblatt 1 . 1 National Eye Institute, National
Institutes of Health, Bethesda, MD; 2 Kellogg Eye
Center, University of Michigan, Ann Arbor, MI f
5929 — 10:45 IV Secukinumab Is An Effective
Treatment In Patients With Noninfectious Uveitis
Requiring Steroid Sparing Immunosuppressive
Therapy. Erik Letko 1 , S. Yeh 2 , C. L. Grosskreutz 3 ,
U. Pleyer 4 , C. Foster 5 , M. G. Brigell 6 . 1 Corneal
Consultants of Colorado, Denver, CO;
2
Ophthalmology Eye Center, Atlanta, GA; 3 Global
Translational Medicine Head for Ophthalmology
Novartis Institutes for Biomedical Research,
Cambridge, MA; 4 Ophthalmology University
Charite Berlin, Berlin, Germany; 5 Ophthalmology
Ocular Immunol & Uveitis Foundation, Cambridge,
MA; 6 Novartis Institutes for BioMedical Research,
Inc., Cambridge, MA *CR, f
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
372

Thursday – Papers/Minisymposium – 5930 – 5944
5930 — 11:00 Clinical Characteristics and
Treatment Outcomes of Juvenile Idiopathic
Arthritis Associated Uveitis. Nisha Acharya 1, 2 ,
S. Patel 3 , G. Homayounfar 1 , W. Enanoria 1, 2 , A.
Shakoor 1 , A. Chakrabarti 3 , D. A. Goldstein 3, 4 .
1
F.I. Proctor Foundation, University of California,
San Francisco, San Francisco, CA; 2 Department
of Ophthalmology, University of California, San
Francisco, San Francisco, CA; 3 Department of
Ophthalmology, University of Illinois College of
Medicine at Chicago, Chicago, IL; 4 Department of
Ophthalmology, Northwestern Memorial Feinberg
School of Medicine, Chicago, IL *CR
5931 — 11:15 12-Month Results of the SAVE
Study - Sirolimus as Therapeutic Approach
to UVEitis: A Randomized Study to Assess
the Safety and Bioactivity of Intravitreal and
Subconjunctival Injections of Sirolimus in
Patients with Non-infectious Uveitis. Quan
Dong Nguyen 1, 2 , M. A. Ibrahim 2 , A. L. Watters 2 ,
Y. J. Sepah 2 , M. G. Bittencourt 2 , J. Yohannan 2 , J.
Naor 3 , N. K. Shams 3 , D. V. Do 2 . 1 Diseases of the
Retina & Uveitis, Johns Hopkins Univ, Wilmer Eye
Inst, Baltimore, MD; 2 Retinal Imaging Research
and Reading Center, Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD; 3 Santen, Inc,
Emeryville, CA *CR, f
5932 — 11:30 The Course of Uveitis in
Pregnancy and the Postpartum. Lyndell Lim 1, 5 ,
N. Chiam 1 , R. J. Stawell 3, 4 , L. Busija 1 , A. J. Hall 2, 3 .
1
Centre for Eye Research Australia, University
of Melbourne, East Melbourne, VIC, Australia;
2
Ophthalmology, The Alfred Hospital, Melbourne,
VIC, Australia; 3 Eye Surgery Associates,
Melbourne, VIC, Australia; 4 Ocular Immunology
Clinic, Royal Victorian Eye and Ear Hospital, East
Melbourne, VIC, Australia; 5 Victoria Parade Eye
Consultants, East Melbourne, VIC, Australia *CR
5933 — 11:45 Visual outcomes in uveitis with
angiographic macular leakage treated with the
fluocinolone acetonide implant or standard
treatment. Thomas A. Albini 1 , D. A. Goldstein 2 ,
D. Callanan 3 , Q. Nguyen 4 , S. K. Srivastava 5 .
1
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 2 Ophthalmology, Northwestern
Universty, Chicago, IL; 3 Ophthalmology, Texas
Retina Associates, Dallas, TX; 4 Ophthalmology,
Johns Hopkins University, Baltimore, MD;
5
Ophthalmology, Cleveland Clinic, Cleveland, OH
*CR, f
5934 — 12:00 Health utility in the Multicenter
Uveitis Steroid Treatment Trial. Elizabeth
A. Sugar 1, 3 , A. E. Burke 2, 3 , L. T. Drye 2, 3 , J.
Holbrook 2, 3 , J. H. Kempen 5, 6 , J. E. Thorne 2, 4 ,
K. D. Frick 7 . 1 Biostatistics, The Johns Hopkins
Bloomberg School of Public Health, Baltimore,
MD; 2 Epidemiology, The Johns Hopkins
Bloomberg School of Public Health, Baltimore,
MD; 3 Center for Clinical Trials, The Johns Hopkins
Bloomberg School of Public Health, Baltimore,
MD; 4 Ophthalmology, The Johns Hopkins
University School of Medicine, Baltimore, MD;
5
Ocular Inflammation Service, The University of
Pennsylvania, Philadelphia, PA; 6 Center for Clinical
Epidemiology and Biostatistics, Department of
Biostatistics and Epidemiology, The University
of Pennsylvania, Philadelphia, PA; 7 Health Policy
and Management, The Johns Hopkins Bloomberg
School of Public Health, Baltimore, MD *CR, f
608
Thursday, May 09, 2013 10:30 AM-12:15 PM
Anatomy/Pathology
526 Anatomy Challenges for the Future
Moderators: Ludwig M. Heindl and
Robert J. Zawadzki
5935 — 10:30 Anatomy of CD31+ blood
vessels and LYVE1+ macrophages in the adult
human sclera. Simona L. Schlereth 1 , F. Schroedl 2 ,
R. Grajewski 1 , C. Cursiefen 1 , L. M. Heindl 1 .
1
Ophthalmology, University of Cologne, Cologne,
Germany; 2 Paracelsus Medical University, Salzburg,
Austria *CR
5936 — 10:45 Optic Nerve Parameters in
Preterm and Full Term Infants Using Spectral
Domain Optical Coherence Tomography
(SDOCT). Amy Y. Tong 1 , R. S. Maldonado 2 ,
D. Tran-Viet 2 , A. L. Rothman 1 , E. L. Yuan 2 , A.
M. Dubis 2 , S. Stinnett 2 , M. A. El-Dairi 2 , S. F.
Freedman 2 , C. A. Toth 2 . 1 Duke University School
of Medicine, Durham, NC; 2 Duke Eye Center,
Durham, NC *CR
5937 — 11:00 Expression of the
Lymphangiogenic Marker Podoplanin (D2-40)
in Human Fetal Eyes. Martina C. Herwig 1 , K.
Münstermann 2 , U. Klarmann 3 , K. U. Loeffler 1 , A.
M. Müller 2 . 1 Dept. of Ophthalmology, University
of Bonn, Bonn, Germany; 2 Dept. of Pediatric
Pathology, University of Bonn, Bonn, Germany;
3
Institute of Medical Biometry, University of Bonn,
Bonn, Germany
5938 — 11:15 Canonical Wnt signaling is
required for lacrimal gland formation, eyelid
closure and to suppress corneal cell fate in mouse
conjunctival and eyelid epithelium. Jie Huang 1 , Y.
Liu 1 , D. C. Beebe 1, 2 . 1 Ophthalmology, Washington
University, Brentwood, MO; 2 Cell Biology and
Physiology, Washington University, St. Louis, MO
*CR
5939 — 11:30 Sox9 regulates the formation
and branching morphogenesis of mouse ocular
glands. Ziyan Chen 2, 1 , J. Huang 1 , Y. Liu 1 , D. C.
Beebe 1, 3 . 1 Ophthalmology and Visual Sciences,
Washington University in St. Louis, St. Louis,
MO; 2 Zhongshan Ophthalmic Center, State Key
Laboratory of Ophthalmology, Sun Yat-sen
University, Guangzhou, China; 3 Cell Biology and
Physiology, Washington University in St. Louis, St.
Louis, MO *CR
5940 — 11:45 Identification of Signaling
Pathways involved in Retina-Lens Tissue
Interactions using Embryos Over-Expressing
Pairedless Pax6 (Pax6ΔPD) Gene. Vijay K.
Kalaskar 1 , J. D. Lauderdale 2 . 1 Neuroscience
Division of Biomedical & Health Sciences Institute,
University of Georgia, Athens, GA; 2 Cellular
Biology, University of Georgia, Athens, GA
5941 — 12:00 Topical small molecule
translational bypass therapy rescues Pax6
aniridia mutant phenotype. Cheryl Y. Gregory-
Evans, X. Wang, A. Metcalfe, X. Shan, K. Gregory-
Evans. Ophthalmology, University of British
Columbia, Vancouver, BC, Canada
609
Thursday, May 09, 2013 10:30 AM-12:15 PM
Lens
527 Cataract II
Moderators: Linda Musil and Michael Wormstone
5942 — 10:30 Effects of basic FGF on the
regeneration of lens in New Zealand Albino
rabbits. Zhenzhen Liu, M. Wu, Y. Zhu, W. Zhang,
X. Tan, S. Huang, F. Shang, Y. Liu. Lab of Cataract
Prevention and Treatment, Zhongshan Ophthalmic
Center, Guangzhou, China
5943 — 10:45 FGF2 Antagonizes the TGFβ2-
Induced Aberrant Expression of Tropomyosin
and α-Smooth Muscle Actin in Mouse and
Human Lens Epithelial Cells and Has a Role
in Posterior Capsule Opacity. Eri Kubo 1 ,
N. Hasanova 1 , H. Osada 1 , E. Kiyokawa 2 , H.
Sasaki 1 , N. Fatma 3 , D. P. Singh 3 . 1 Department of
Ophthalmology, Kanazawa Medical University,
Ishikawa, Japan; 2 Department of Oncogenic
Pathology, Kanazawa Medical University, Ishikawa,
Japan; 3 Department of Ophthalmology, University
of Nebraska Medical Center, Omaha, NE
5944 — 11:00 Increased Matrix Rigidity
Drives Repair Cell Transdifferentiation into
Myofibroblasts in a PCO Model. Janice L.
Walker 1, 2 , B. Bleaken 1 , M. Stepp 3, 4 , A. S. Menko 1, 2 .
1
Pathology, Anatomy & Cell Biology, Thomas
Jefferson University, Philadelphia, PA; 2 Wills Vision
Research Center at Jefferson, Philadelphia, PA;
3
Department of Anatomy and Regenerative Biology,
The George Washington Universtiy, Washington,
DC; 4 Department of Ophthalmology, The George
Washington Universtiy, Washington, DC
Thursday Papers/
Minisymposium
10:30 am – 12:15 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
373

5945 – 5963 – Thursday – Papers/Minisymposium
Thursday Papers/
Minisymposium
10:30 am – 12:15 pm
5945 — 11:15 STEP Phosphatase and AMPA
Receptor GluA2 Regulation in Diabetes-
Induced Cataract in Rabbit. Peter Frederikse 1 ,
C. Kasinathan 1 , M. Bhattacharyya 1 , N. J. Kleiman 2 .
1
University of Medicine and Dentistry of New
Jersey, Newark, NJ; 2 Mailman School of Public
Health, Columbia University, New York City, NY
*CR
5946 — 11:30 APC-Coated Intraocular Lenses
Reduce the Occurrence of PCO in a Human
Anterior Chamber Model. Raffael Liegl, C. M.
Wertheimer, M. Kernt, A. Wolf, A. Kampik, K. Eibl-
Lindner. Ophthalmology, Ludwig-Maximilians-
University Munich, Muenchen, Germany *CR
5947 — 11:45 The study of surface properties
of intraocular lens by nanometric analysis.
Jun Kong 1, 2 , N. Yang 1 , X. Li 1 , Y. Lu 1 , J. Zhang 1 .
1
Ophthalmology, the 4th Affiliated Hospital of
China Medical University, Shenyang, China;
2
Ophthalmology, UCSD, San Diego, CA
5948 — 12:00 Epilepsy Cataract: Valproic
Acid Suppresses the Nrf2 Dependent Stress/
Antioxidant Protection. Toshimichi Shinohara 1 ,
P. Periyasamy 1 , K. R. Bidasee 2 , M. Ayaki 3 , E.
Rajan 1 . 1 Ophthalmol and Vis Sci, Univ of Nebraska
Medical Center, Omaha, NE; 2 Pharmacology and
Experimental Neuroscience, Univ of Nebraska
Medical Center, Omaha, NE; 3 Ophthalmology, Mita
Hospital, Tokyo, Japan
611-614
Thursday, May 09, 2013 10:30 AM-12:15 PM
Retinal Cell Biology
528 Photoreceptor Degeneration
and Death
Moderators: Rong Wen and Xi-Qin Ding
5949 — 10:30 Modulation of the rate of
retinal degeneration in T17M RHO mice
by reprogramming the Unfolded Protein
Response. Marina S. Gorbatyuk 1 , S. Choudhury 2 ,
S. R. Nashine 2 , Y. Bhootada 1 , A. S. Lewin 3 , O.
Gorbatyuk 3 . 1 Vision Sciences, UAB, Birmingham,
AL; 2 Cell Biology and Anatomy, UNTHSC, Fort
Worth, TX; 3 Molecular Genetics & Microbiology,
UF, Gainesville, FL *CR
5950 — 10:45 How long does a photoreceptor
take to die? Temporal characteristics of neuronal
cell death in the retina. Francois Paquet-Durand 1 ,
A. Sahaboglu-Tekgöz 1 , O. Paquet-Durand 2 ,
J. Dietter 1 , P. A. Ekstrom 3 , B. Hitzmann 2 , M.
Ueffing 1 . 1 Experimental Ophthalmology, Institute
for Ophthalmic Research, Tuebingen, Germany;
2
Institute of Food Science and Biotechnology,
University of Stuttgart Hohenheim, Stuttgart,
Germany; 3 Clinical Sciences, University of Lund,
Lund, Sweden
5951 — 11:00 Expression and localization
of cell cycle and proliferation genes in early
retinal degeneration models. Sem Genini, K. L.
Gardiner, G. D. Aguirre. Clinical Studies, Univ of
Pennsylvania, Sch Veterinary Med, Philadelphia, PA
5952 — 11:15 cGMP Accumulation Causes
Cone Degeneration in CNG Channel Deficiency.
Arjun Thapa 1 , J. Xu 1 , L. M. Morris 1 , H. Ma 1 , S.
Michalakis 2 , M. Biel 2 , W. Baehr 3 , A. M. Dizhoor 4 ,
I. V. Peshenko 4 , X. Ding 1 . 1 Cell Biology, Univeristy
of OKlahoma, Oklahoma City, OK; 2 Center for
Integrated Protein Science Munich (CIPSM)
and Department of Pharmacy, Center for Drug
Research, Ludwig-Maximilians-Universität
München, München, Germany; 3 The John A. Moran
Eye Center, University of Utah, Salt Lake CIty, UT;
4
Department of Basic Sciences and Pennsylvania
College of Optometry, Salus University, Elkins
Park, PA
5953 — 11:30 Exploration of the Mechanisms
of Cone Photoreceptor Death in the Deficiency
of Phosphodiesterase. Lynsie M. Morris 1 , Z. D.
Ma 1 , A. Thapa 1 , H. Ma 1 , S. Michalakis 2 , M. Biel 2 ,
W. Baehr 3 , X. Ding 1 . 1 Cell Biology, OU Health
Sciences Center, Oklahoma City, OK; 2 Center for
Drug Research, Ludwig-Maximilians-Universität
München, Munich, Germany; 3 John A. Moran Eye
Center, University of Utah, Salt Lake City, UT
5954 — 11:45 Genetic ablation of DHDDS
induces photoreceptor degeneration. Rong Wen,
Y. Li, Z. Wang, B. L. Lam, Y. Li. Bascom Palmer Eye
Inst, University of Miami, Miami, FL *CR
5955 — 12:00 Rip3 knockdown rescues
photoreceptor cell death in pde6c zebrafish
model of achromatopsia. Ishaq Ahmed
Viringipurampeer, Z. Mohammadi, X. Shan, K.
Gregory-Evans, C. Y. Gregory-Evans. Department
of Ophthalmology and Visual Sciences, University
of British Columbia, Vancouver, BC, Canada
615-617
Thursday, May 09, 2013 10:30 AM-12:15 PM
Clinical/Epidemiologic Research
529 Refractive Error and Visual
Function: What Affects How We See
Moderators: Susan Vitale and Kathryn A. Rose
5956 — 10:30 Atherosclerosis, Inflammation
and Decline in Contrast Sensitivity: The Beaver
Dam Offspring Study. Karen J. Cruickshanks 1, 2 ,
D. M. Nondahl 1 , D. S. Dalton 1 , G. Huang 3, 2 , B.
E. Klein 1 , R. Klein 1 , F. Nieto 2 , C. R. Schubert 1 .
1
Ophthalmology and Visual Sciences, U of WI
SMPH, Madison, WI; 2 Population Health Sciences,
U of WI SMPH, Madison, WI; 3 National Chiao
Tung University, Hsinchu, Taiwan
5957 — 10:45 Risk factors for lacking adequate
refractive correction in the U.S., NHANES
1999-2008. Susan Vitale, R. Sperduto, E. Y. Chew,
F. L. Ferris. Div Epidemiol & Clin Applications,
National Eye Inst/NIH, Bethesda, MD *CR
5958 — 11:00 Heterogeneity of effects in
refractive error: lessons from the CREAM
Consortium genome-wide association metaanalysis.
Christopher J. Hammond 1 , P. G. Hysi 1 ,
V. J. Verhoeven 2 , C. C. Klaver 2 . 1 Ophthalmology,
King’s College London, London, United Kingdom;
2
Ophthalmology & Epidemiology, Erasmus Medical
Center, Rotterdam, Netherlands *CR
5959 — 11:15 The role of time outdoors on
the progression of refractive error in Australian
children. Kathryn A. Rose 1 , A. French 1 , P. Mitchell 2 ,
I. G. Morgan 3 . 1 Discipline of Orthoptics, University
of Sydney, Sydney, NSW, Australia; 2 Department
of Ophthalmology, University of Sydney, Sydney,
NSW, Australia; 3 Research School of Biology,
Australian National University, Canberra, ACT,
Australia *CR
5960 — 11:30 Influence of education on
penetrance of myopia genes. Caroline C.
Klaver 1, 2 , V. J. Verhoeven 1, 2 , G. H. Buitendijk 1, 2 , J.
R. Vingerling 1, 2 . 1 Ophthalmology, Erasmus Medical
Center, Rotterdam, Netherlands; 2 Epidemiology,
Erasmus Medical Center, Rotterdam, Netherlands
*CR
5961 — 11:45 School readiness, behavioural
and emotional difficulties: the impact of
strabismus and its treatment. Phillippa
Cumberland 1, 3 , J. S. Rahi 1, 2 . 1 MRC Centre for
Epidemiology of Child Health, UCL Institute of
Child Health, London, United Kingdom; 2 UCL
Institute of Ophthalmology, London, United
Kingdom; 3 Ulverscroft Vision Research Group,
London, United Kingdom
5962 — 12:00 The Magnitude and Symmetry
of Refractive and Corneal Astigmatism in
Children. John D. Twelker, J. M. Miller, D. H.
Messer, E. M. Harvey. Ophthal & Vision Science,
University of Arizona, Tucson, AZ
618-620
Thursday, May 09, 2013 10:30 AM-12:15 PM
Physiology/Pharmacology
530 Gene Therapy and Delivery
Moderators: Tao L. Lowe and Caterina Gagliano
5963 — 10:30 Oral delivery of bioencapsulated
myelin basic protein ameliorate amyloid burden
and RGC loss in transgenic mouse model of
Alzheimer’s disease. Qiuhong Li 1 , A. Verma 1 ,
P. Zhu 1 , P. K. Shil 1 , N. Kohli 2 , D. Westerveld 2 , H.
Daniell 2 . 1 Ophthalmology, University of Florida,
Gainesville, FL; 2 University of Central Florida,
Orlando, FL
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
374

Thursday – Papers/Minisymposium – 5964 – 5981
5964 — 10:45 Treatment of Patients with
Leber Congenital Amaurosis Type 2 with an
AAV Vector Expressing RPE65. Tim Stout 1 , R. G.
Weleber 1 , M. McBride 1 , D. J. Wilson 1 , D. Peters 1 ,
M. R. Humphries 3 , T. R. Flotte 3 , L. J. Jensen 1 , A.
Lauer 1 , J. D. Chulay 2 . 1 Ophthalmology, Casey
Eye Institute-OHSU, Portland, OR; 2 AGTC Inc,
Alachua, FL; 3 School of Medicine, University of
Massachusetts, Worcester, MA *CR, f
5965 — 11:00 Sustained Therapeutic Reversal
of Canine Bestrophinopathy with Gene Therapy
using Recombinant AAV2. Karina E. Guziewicz 1 ,
A. M. Komaromy 2 , S. Iwabe 1 , A. V. Cideciyan 3 ,
E. V. Dutrow 1 , B. Zangerl 4 , W. A. Beltran 1 , S. G.
Jacobson 3 , W. W. Hauswirth 5 , G. D. Aguirre 1 .
1
Clinical Studies, University of Pennsylvania,
Philadelphia, PA; 2 Department of Small Animal
Clinical Sciences, Michigan State University, East
Lansing, MI; 3 Scheie Eye Institute, University
of Pennsylvania, Philadelphia, PA; 4 Centre for
Eye Health, University of New South Wales,
Kensington, NSW, Australia; 5 Department of
Ophthalmology, University of Florida, Gainesville,
FL *CR
5966 — 11:15 Vertical Gene Transfer of Mutant
Human G11778A ND4 in Next Generation Mito-
Mice. Hong Yu, S. S. Ozdemir, T. Chou, V. Porciatti,
J. Guy. Ophthalmology, Bascom Palmer Eye Inst,
Univ of Miami, Miami, FL
5967 — 11:30 Gene Therapy with the
Mitochondrial Heat Shock Protein 70 (mtHSP70)
Chaperone Supresses Neurodegeneration and
Irreversible Visual Loss in Experimental Optic
Neurits. Venu Talla, S. S. Ozdemir, T. Chou, V.
Porciatti, J. Guy. Ophthalmology, Bascom Palmer
Eye Institute, University of Miami, Miller School of
Medicine, Miami, FL
5968 — 11:45 AAV-mediated gene therapy
restores retinal function and vision in the
RPGRIP1-deficient dog. Lolita Petit 1 , E.
Lhériteau 1 , M. Weber 2 , G. Le Meur 2 , J. Deschamps 3 ,
P. Moullier 1, 4 , F. Rolling 1 . 1 Inst de Recherche
Therapeutique 1, Lab de Therapie Genique
INSERM UMR 1089, Nantes, France; 2 Service
d’Opthalmologie, CHU-Hôtel Dieu, Nantes,
France; 3 Emergency and Critical Care Unit,
ONIRIS, Nantes-Atlantic College of Veterinary
Medicine-Food Science and Engineering, Nantes,
France; 4 Department of Molecular Genetics and
Microbiology, College of Medicine, University of
Florida, Gainesville, FL
5969 — 12:00 Gene therapy in Leber
congenital amaurosis due to rpe mutations:
results of the first six patients included in a
clinical trial. Guylene Le Meur 1 , P. Lebranchu 2 ,
Y. Péréon 3 , S. Schmitt 4 , S. Bézieau 5 , P. Moullier 6 ,
F. Rolling 7 , M. Weber 8 . 1 CHU hotel dieu, Nantes,
France; 2 CHU hotel Dieu, Nantes, France; 3 CHU
hotel Dieu, Nantes, France; 4 CHU hotel Dieu,
Nantes, France; 5 CHU hotel Dieu, Nantes, France;
6
INSERM UMR 1089, Nantes, France; 7 INSERM
UMR 1089, Nantes, France; 8 CHU hotel Dieu,
Nantes, France f
TCC LL 4/5
Thursday, May 09, 2013 10:30 AM-12:15 PM
Low Vision Group
531 Beyond Large Print: Advances in
Accessibility and Technology for the
Visually Impaired - Minisymposium
Over the last 20 years technological innovation
has advanced at an amazing pace and in doing so
has revolutionized accessibility to information for
people with vision impairments. Presenters in this
symposium will provide an overview of how recent
and future advances in technology and computer
vision can be utilized by vision scientists to provide
immediate and potentially life-changing solutions
for individuals with vision impairments.
Moderators: James B. Nolan, Ava K. Bittner and
Alexandra R. Bowers
— 10:30 Introduction
— 10:40 Oberdorfer Award in Low Vision
Presentation
5970 — 10:45 Oberdorfer Award in Low
Vision – Using the Cloud and Emerging
Technologies to Provide On-demand Low Vision
Solutions Anytime, Anywhere, on Any Device.
Gregg Vanderheiden. Industrial Engineering and
Biomedical Engineering, University of Wisconsin-
Madison, Madison, WI
5971 — 11:15 Accessibility and Vision
Rehabilitation Science: Tear Down That Wall!.
Aries Arditi. Visibility Metrics LLC, Chappaqua,
NY
5972 — 11:35 Computer Vision-based Assistive
Technology for the Visually Impaired. James
Coughlan. Smith-Kettlewell Eye Research Institute,
San Francisco, CA
5973 — 11:55 Using Text Detection to Help
Low Vision Users. Peter Hallinan. The Blindsight
Corporation, Berkeley, CA *CR
TCC 303
Thursday, May 09, 2013 10:30 AM-12:15 PM
Cornea
532 Corneal Wound Repair and Healing
Moderators: Winston W. Kao and Peter S. Reinach
5974 — 10:30 Effect of Advanced Glycation
End Products on apoptosis of Human Corneal
Epithelial Cells. Xinyi Wu. Ophthal QiLu Hosp/
Ophthal, Shandong University, Jinan, Shandong,
China
5975 — 10:45 Type III Intermediate Filament
Overexpression in the Genesis of Corneal
Fibrosis. Royce Mohan 1 , L. Cauley 2 , P. Bargagna-
Mohan 1 . 1 Neuroscience, University of Connecticut
Health Center Health Center, Farmington, CT;
2
Immunology, University of Connecticut Health
Center, Farmington, CT *CR
5976 — 11:00 Genome-wide transcriptional
analysis of differentially expressed genes in
diabetic, healing corneal epithelial cells. Fushin
X. Yu. Dept of Ophthalmology, Wayne State Univ/
Kresge Eye Inst, Detroit, MI
5977 — 11:15 Corneal epithelial-neuronal
signaling is compromised under environmental
stress. Vickery E. Trinkaus-Randall, A. Lee, K.
Derricks, M. Nugent. Ophthalmology L904, Boston
University Sch of Med, Boston, MA
5978 — 11:30 Ciliary neurotrophic Factor
accelerates corneal Nerve Regeneration in a
Murine Model. Rudolf F. Guthoff, M. Reichard, M.
Hovakimyan, O. Stachs. Ophthalmology, University
of Rostock, Rostock, Germany
5979 — 11:45 The Mechanotransducers
YAP and TAZ are Modulated by Substratum
Compliance in Corneal Stromal Cells and
during Corneal Wound Healing. Christopher J.
Murphy 1, 2 , S. M. Thomasy 1 , V. K. Raghuanthan 1 , C.
M. Reilly 3 , P. Russell 1 . 1 Surgical and Radiological
Sciences, School of Veterinary Medicine, University
of California, Davis, Davis, CA; 2 Ophthalmology
& Vision Science, School of Medicine, University
of California, Davis, Davis, CA; 3 Pathology,
Immunology & Microbiology, School of Veterinary
Medicine, University of California, Davis, Davis,
CA *CR
5980 — 12:00 Anti-inflammatory therapy
changes fate of alkali burned corneas associated
with dry eye. Cintia S. De Paiva, F. S. Pelegrino,
E. A. Volpe, S. C. Pflugfelder. Ophthalmology,
Baylor College of Medicine, Houston, TX *CR
TCC 305
Thursday, May 09, 2013 10:30 AM-12:15 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
533 Disruptions to Visual Development:
Detection, Treatment and
Consequences
Moderators: Susan A. Cotter and Agnes M. Wong
5981 — 10:30 Beyond Screening for Risk
Factors…The Objective Detection of Strabismus
and Amblyopia. Susan E. Yanni 1 , R. M. Jost 1 , C. L.
Beauchamp 2 , D. R. Stager 2 , S. David 3 , L. Dao 3 , M.
R. Nolan 1 , E. E. Birch 1, 4 . 1 Retina Foundation of the
Southwest, Dallas, TX; 2 Pediatric Ophthalmology
and the Center for Adult Strabismus, Dallas, TX;
3
Pediatric Ophthalmology and Adult Strabismus,
Plano, TX; 4 Ophthalmology, University of Texas
Southwestern Medical Center, Dallas, TX *CR
Thursday Papers/
Minisymposium
10:30 am – 12:15 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
375

5982 – 5987 – Thursday – Papers/Minisymposium
5982 — 10:45 Are Referrals From the
Plusoptix S09 Significantly More Accurate Than
the LEA/Random Dot E Screening System for
Preschool Children Ages 3-5. Joannah Vaughan,
R. Arao, T. Dale, M. F. Chiang, D. J. Karr. Casey
Eye Institute, Oregon Health & Science University,
Portland, OR *CR
5983 — 11:00 The relationship between
visual function and scores on the Beery Visual-
Motor Integration test in 4.5 year old children
born with developmental risk factors. Arijit
Chakraborty 1 , N. S. Anstice 1 , R. J. Jacobs 1 , J. E.
Harding 2 , J. Paynter 2 , T. Wouldes 3 , B. Thompson 1 .
1
Optometry and Vision Science, University of
Auckland, Auckland, New Zealand; 2 Liggins
Institute, University of Auckland, Auckland, New
Zealand; 3 Psychological Medicine, University of
Auckland, Auckland, New Zealand *CR
5984 — 11:15 Comparison of
electroretinographical responses in albinism,
idiopathic infantile nystagmus and healthy
controls. Zhanhan Tu 1 , C. Degg 2 , I. Gottlob 1 , F. A.
Proudlock 1 . 1 Opthalmology Group, University of
Leicester, Leicester, United Kingdom; 2 Medical
Physics, University Hospitals of Leicester,
Leicester, United Kingdom
5985 — 11:30 Timing matters: Relationship
between age at initial surgery and monocular
grating acuity at 12 months in the Infant
Aphakia Treatment Study (IATS). E Eugenie
Hartmann 1 , M. J. Lynn 2 , S. R. Lambert 3 .
1
Department of Vision Sciences, Univ of Alabama
at Birmingham, Birmingham, AL; 2 Department of
Biostatistics and Bioinformatics; Rollins School
of Public Health, Emory University, Atlanta,
GA; 3 Department of Ophthalmology; School of
Medicine, Emory University, Atlanta, GA f
5986 — 11:45 A prospective non-randomized
study on early vs standard surgery for infantile
esotropia in children: An interim report on
optokinetic response. Agnes M. Wong 1, 2 , H. C.
Goltz 1, 2 , A. Blakeman 2 , L. Colpa 1 . 1 Ophthalmology
& Vision Sciences, Hospital for Sick Children,
Toronto, ON, Canada; 2 Ophthalmology & Vision
Sciences, University of Toronto, Toronto, ON,
Canada f
Thursday Papers/
Minisymposium
10:30 am – 12:15 pm
5987 — 12:00 Factors Associated with
Poor Health-Related Quality of Life in Adult
Strabismus. Sarah R. Hatt, D. A. Leske, L.
Liebermann, J. M. Holmes. Ophthalmology, Mayo
Clinic, Rochester, MN
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
376

Thursday – Posters – 5988 – 6008
Exhibit Hall A0032-A0042
Thursday, May 09, 2013 10:30 AM-12:15 PM
Immunology/Microbiology / Cornea
534 Corneal Infection/Inflammation II
Moderator: Alison M. McDermott
5988 — A0032 Determining the Efficacy of a
Novel Targeted Therapeutic Approach Against
Herpes Simplex Virus-1 in an Organotypically
Cultured Corneal Model. Paul J. Park 1 , T. Valyi-
Nagy 3 , D. Shukla 1, 2 . 1 Ophthalmology and Visual
Sciences, University of Illinois at Chicago, Chicago,
IL; 2 Microbiology and Immunology, University
of Illinois at Chicago, Chicago, IL; 3 Pathology,
University of Illinois at Chicago, Chicago, IL
5989 — A0033 STAT3/SOCS3 axis modulates
CD8-mediated host immunity against HSV-1.
Fatemeh Navid 1 , C. Yu 1 , I. M. Dambuza 1 , G. Frank 2 ,
C. Egwuagu 1 . 1 Laboratory of Immunology, NEI,
Bethesda, MD; 2 Cellular Biology Section, NIAID,
Bethesda, MD
5990 — A0034 Targeting host kinases as
potential therapeutic targets for the treatment
of herpes keratitis. Oleg Alekseev, J. Azizkhan-
Clifford. Biochemistry & Molecular Biology, Drexel
Univ College of Medicine, Philadelphia, PA
5991 — A0035 Efficacy of HSV1-specific
meganucleases in a mouse model of relapsing
herpes keratitis. Marc Labetoulle 1, 2 , E. E.
Gabison 3 , A. Rousseau 1 , N. Huot 2 , D. Pasdeloup 2 ,
S. Barradeau 4 , C. Mahiet 4 , B. Chapelier 3 , M.
Breckler 2 . 1 Ophthalmology, Hopital Bicetre,
South Paris University, Le Kremlin Bicetre,
France; 2 Laboratoire de Virologie Moleculaire
et Structurale, CNRS UPR 3296, Gif sur Yvette,
France; 3 Institut de la Vision, Paris, France;
4
Genomic Vision, Bagneux, France *CR
5992 — A0036 Preclinical evaluation of new
therapies in a fungal keratitis rat model. M Livia
Bajenaru, A. C. Santos, M. J. Falter, M. Ruggeri, J.
Ponmattam, E. P. Hernandez, M. Abou Shousha, V.
L. Perez, D. Miller, E. C. Alfonso. Ophthalmology,
Univ of Miami, Bascom Palmer Eye Inst, Miami,
FL *CR
5993 — A0037 Expression of NOD-like
receptors(NLRs) and NODs in corneal diseases.
Na-Kyung Ryoo 1, 2 , J. Ko 2 , H. Lee 2 , M. Kim 1 , W.
Wee 1 , J. Oh 1, 2 . 1 Ophthalmology, Seoul National
University Hospital, Seoul, Republic of Korea;
2
Clinical Research Institute, Seoul National
University Hospital, Seoul, Republic of Korea
5994 — A0038 Cytokine Profiling in Mouse
Cornea During Wound Healing in Response
to CAP37 Treatment. Anne Kasus-Jacobi 1 ,
G. L. Griffith 2 , M. R. Lerner 3 , H. A. Pereira 1, 2 .
1
Pharmaceutical Sciences, University of Oklahoma
Health Sciences Center, Oklahoma City, OK;
2
Pathology, University of Oklahoma Health
Sciences Center, Oklahoma City, OK; 3 Surgery,
University of Oklahoma Health Sciences Center,
Oklahoma City, OK
5995 — A0039 Expression of PAR1 and 2 on
Human Corneal Epithelial Cells and Induction
of Pro-inflammatory Cytokine Secretion by
Acanthamoeba MIP-133 and aPA. Hassan
Alizadeh 1, 2 , M. Abdi 1, 2 . 1 Cell Biology and Anatomy,
UNTHSC Fort Worth TX, Fort Worth, TX; 2 North
Texas Eye Research Institute, UNTHSC, Fort
Worth, TX
5996 — A0040 Role of ST2 Signaling in IL-
33 Induced Inflammation in Human Corneal
Epithelium. Jing Lin, G. Zhao, L. Zhang.
Ophthalmology, the Affiliated Hospital of Medical
College, Qingdao University, Qingdao, China
5997 — A0041 Antimicrobial Peptides in the
In Vitro Corneal Response to Fungal Pathogens.
Satya Sree N. Kolar, H. Baidouri, A. McDermott.
Optometry and Vision Sciences, University of
Houston, College of Optometry, Houston, TX
5998 — A0042 Corneal epithelial-cell necrosis
and apoptosis directly induced by fungal isolates
from patients with keratomycosis. Pablo L.
Goldschmidt 1 , R. Zemihi 1 , D. Ghoubay-Benallaoua 1 ,
C. Temstet 1 , L. Batellier 1 , V. Borderie 2 , L. Laroche 2 ,
C. Chaumeil 1 . 1 Laboratoire, Centre Hospitalier
National d’Ophtalmologie des Quinze-Vingts, Paris,
France; 2 Service 5, Centre Hospitalier National
d’Ophtalmologie des Qui, Paris, France
Exhibit Hall A0062-A0116
Thursday, May 09, 2013 10:30 AM-12:15 PM
Cornea / Visual Psychophysics / Physiological
Optics
535 Dry Eye and Lacrimal Gland V
Moderators: De-Quan Li and Norihiko Yokoi
5999 — A0062 Toll-like Receptor Agonists
Stimulate Matrix Metalloproteinase-9
Production in Ocular Surface Cells. Rachel L.
Redfern, K. Stout, K. Dionne. College of Optometry,
University of Houston, Houston, TX
6000 — A0063 Corneal Epithelial Cell
Protective and Wettability-enhancing Properties
of Hyaluronic Acid + PEG 8000 in an Artificial
Tear Product. Stephen Davio, M. E. Cavet, K. L.
Harrington, A. Walsh, Z. Marlowe, B. Glass, P.
Sarkar. Pharmaceutical R&D, Bausch & Lomb,
Rochester, NY *CR
6001 — A0064 Change of Tear Secretion in the
Lacrimal Glands of High-Fat Diet-Fed C57BL/6J
Mice. Takaaki Inaba, M. Kawashima, A. Ito, M.
Watanabe, K. Shinmura, T. Kawakita, K. Tsubota.
Keio University, Tokyo, Japan *CR
6002 — A0065 Comparison of two rodent
models of dry eye induced by Scopolamine.
Pierre-Paul Elena 1 , N. Cimbolini 1 , S. Antonelli 1 , L.
Feraille 1 , S. Barabino 2 , P. Margaron 1 . 1 Iris Pharma,
La Gaude, France; 2 Clinica Oculistica, Genova,
Italy *CR
6003 — A0066 The Composition of Fatty
Acids in Human Meibum. Tomo Suzuki 1, 2 , S.
Kamada 1, 2 , T. Tajika 3 , S. Fujiwara 4 , S. Kinoshita 1 .
1
Ophthalmology, Kyoto Prefectural University of
Medicine, Kyoto, Japan; 2 Ophthalmology, Kyoto
City Hospital, Kyoto, Japan; 3 Senju Pharmaceutical
Co. LTD., Osaka, Japan; 4 Shimadzu Techno-
Research, INC., Kyoto, Japan *CR
6004 — A0067 Topical atorvastatin for the
treatment of dry eye associated with blepharitis.
Stephanie L. Watson 1 , K. G. Ooi 1, 2 , F. A. Billson 1 , D.
Wakefield 3 . 1 Ophthalmology, Save Sight Institute,
University of Sydney, Sydney, NSW, Australia;
2
Department of Ophthalmology, Prince of Wales
Hospital, Sydney, NSW, Australia; 3 Department of
Pathology, School of Medical Sciences, University of
New South Wales, Sydney, NSW, Australia *CR, f
6005 — A0068 Optical quality after instillation
of three different eye drops for dry eye. Shizuka
Koh 1 , N. Maeda 1 , C. Ikeda 1, 2 , Y. Takai 1, 2 , H.
Fujimoto 1 , Y. Oie 1 , T. Soma 1 , M. Tsujikawa 1 , K.
Nishida 1 . 1 Ophthalmology, Osaka University
Graduate School of Medicine, Suita, Japan;
2
Research & Development, Rohto Pharmaceutical
CO.,LTD, Kyoto, Japan *CR
6006 — A0069 Effects of diquafosol
sodium eye drops on tear film stability. Seika
Den 1 , H. Iseda 1 , M. Dogru 1, 2 , J. Shimazaki 1, 2 .
1
Ophthalmology, Tokyo Dental College, Chiba,
Japan; 2 Ophthalmology, Keio University School of
Medicine, Tokyo, Japan *CR, f
6007 — A0070 A multi-lamellar sandwich
model of the tear film lipid layer, TFLL. Peter
E. King-Smith 1 , M. D. Bailey 1 , R. J. Braun 2 .
1
Optometry, Ohio State University, Columbus, OH;
2
Mathematical Sciences, University of Delaware,
Newark, DE
6008 — A0071 Observation of Spreading and
Mechanical Properties of the Tear Film Lipid
Layer Using A High Performance Video-Based
Interferometry System. Daniel R. Powell, P. E.
King-Smith, H. L. Chandler. Vision Science, Ohio
State University, Columbus, OH
Thursday Posters
10:30 am – 12:15 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
377

6009 – 6034 – Thursday – Posters
Thursday Posters
10:30 am – 12:15 pm
6009 — A0072 Symptoms and Findings in a
Norwegian Cohort of Patients with Meibomian
Gland Dysfunction. Ola M. Rygh 1, 2 , J. Eidet 1, 5 ,
X. Chen 1, 5 , T. P. Utheim 1, 3 , A. Thyholdt 4 , O.
Utheim 1, 3 , F. Stojanovic 1, 5 , A. Stojanovic 1, 5 , S.
Raeder 1, 6 . 1 Torreoyneklinikken AS, Oslo, Norway;
2
Eye department, Hospital of Vestfold, Tonsberg,
Norway; 3 Department of Medical Biochemistry,
Oslo University Hospital Ulleval, University of
Oslo, Oslo, Norway; 4 dbConsult, Tromso, Norway;
5
Synslaser Kirurgi, Oslo, Norway; 6 Department of
Clinical Medicine, University of Bergen, Bergen,
Norway
6010 — A0073 Effects of alkali burn of the
ocular surface on meibomian gland structure
in mice. Shin Mizoguchi 1 , Y. Okada 1 , R. Arita 2 ,
S. Saika 1 . 1 Ophthalmology, Wakayama Medical
University, Wakayama, Japan; 2 Itoh Clinic, Tokyo,
Japan *CR
6011 — A0074 Effect of Collection Method
on the Lipid Composition of Meibum Samples.
Carolina Kunnen 1, 2 , S. H. Brown 4 , B. A. Holden 1,
3
, P. Lazon De La Jara 1, 2 , E. B. Papas 1, 3 . 1 Brien
Holden Vision Institute, Sydney, NSW, Australia;
2
School of Optometry and Vision Science,
University of New South Wales, Sydney, NSW,
Australia; 3 Vision CRC, Sydney, NSW, Australia;
4
School of Health Sciences, University of
Wollongong, Wollongong, NSW, Australia *CR
6012 — A0075 Infra-Red Imaging of
Meibomian Glands & Evaluation of the Lipid
Layer in Sjogren’s Syndrome Patients. Sruthi
Srinivasan, K. L. Menzies, L. W. Jones. School of
Optometry, University of Waterloo, Waterloo, ON,
Canada *CR
6013 — A0076 Analysis of a potential
Meibomian Gland Dysfunction-Specific
Symptom Questionnaire in an Independent
Sample. Justin T. Kwan 1 , M. M. Hom 2 , J. R. Paugh 1 .
1
Contact Lens, Dry Eye, Research, Southern
California College of Optometry, Fullerton, CA;
2
Private Practice, Azusa, CA *CR
6014 — A0077 Cigarrete Smoking And
Diabetes But Not Increased Levels Of
Cholesterol, Increase Lipid Peroxidation In
Human Tears. Soledad Benlloch-Navarro 1 ,
V. Sanchez-vallejo 1 , I. Almansa 1 , E. Arnal 2 , D.
Silvestre 1 , M. Miranda 1 . 1 Ciencias Biomédicas,
Universidad CEU Cardenal Herrera, Moncada,
Spain; 2 Fundación Oftalmológica del Mediterráneo,
Valencia, Spain
6015 — A0078 Role of lipid emulsion eye drops
in the improvement of lipid layer thickness
measured with Lipiview. Lara Borrego 1, 2 ,
F. Saenz-Frances 1 , D. Finis 2 , J. M. Benitezdel-Castillo
1 , G. Geerling 2 . 1 Ocular Surface,
Hospital Clinico San Carlos, Madrid, Spain;
2
Ophthalmology, 2University Clinic Hospital,
Düsseldorf, Germany *CR
6016 — A0079 Benzalkonium chloride-induced
rat dry eye model mimics hyperosmolarity in
tear volume deficient dry eye disease. Davi L.
Marques 1 , M. Alves 1, 2 , C. Modulo 1 , L. Malki 1 , P.
Reinach 1 , E. M. Rocha 1 . 1 Universidade de São
Paulo, Ribeirão Preto, Brazil; 2 Pontific Catholic
University of Campinas, Campinas, Brazil
6017 — A0080 Debridement of the Lower
Lid Margin and Line of Marx is effective in
increasing meibomian gland function and patient
comfort. Caroline A. Blackie 1, 2 , D. R. Korb 1, 2 .
1
TearScience, Morrisville, NC; 2 Korb Associates,
Boston, MA *CR
6018 — A0081 The effect of increased
periocular humidity on lipid layer thickness
and ocular comfort of symptomatic contact
lens wearers. Samuel Kim 1 , C. A. Blackie 1, 2 , D.
R. Korb 1, 2 . 1 TearScience, Morrisville, NC; 2 Korb
Associates, Boston, MA *CR
6019 — A0082 The Avian Membrana Nictitans:
Anatomy and Function. Charles S. Schobert, L. B.
Teixeira, R. R. Dubielzig. Dept of Pathobiological
Sciences, UW-Madison School of Vet Med,
Madison, WI *CR
6020 — A0083 Prevalence of incomplete
blinking in dry eye patients evaluated with tear
film interferometry. Joanne Shen. Mayo Clinic in
Arizona, Scottsdale, AZ
6021 — A0084 Expression of proinflammatory
cytokines in tears of aqueous-deficient dry eyes.
Yan Wang, J. Xiang, J. Xu. Ophthalmology, Eye and
ENT Hospital of Fudan University, Shanghai, China
6022 — A0085 Unraveling diagnostic correlates
indicative of Sjögren’s Syndrome. Eduardo
M. Rocha, D. Ribeiro, M. Alves, J. S. Paula, P.
Reinach. Ophthalmology, FMRP-USP, Ribeirao
Preto, Brazil
6023 — A0086 Validation of the Current
Symptoms Questionnaire (CSQ): a metaanalytical
approach. Ping Situ 1 , T. L. Simpson 2 ,
R. L. Chalmers 1 , Z. Wu 1 , C. G. Begley 1 . 1 School
of Optometry, Indiana University Bloomington,
Bloomington, IN; 2 School of Optometry and Vision
Science, University of Waterloo, Waterloo, ON,
Canada *CR
6024 — A0087 The Influence of Punctal
Occlusion on Osmolarity in Dry Eye Subjects.
Jessica Schonfeld, J. S. Pepose, M. A. Qazi. Pepose
Vision Institute, Chesterfield, MO *CR, f
6025 — A0088 Association between depression
and dry eye disease in an adult population.
Antoine Labbe 1, 2 , Y. Wang 1 , C. Baudouin 2 , J. B.
Jonas 1, 3 , L. Xu 1 . 1 Ophthalmology, Beijing Institute
of Ophthalmology, Beijing TongRen Eye Hospital,
Beijing, China; 2 Ophthalmology, CHNO National
Eye Center, Paris, France; 3 Ophthalmology,
Medical Faculty Mannheim-Heidelberg, Mannheim,
Germany *CR
6026 — A0089 In vitro evaporation rate
and stability of four marketed artificial
tears. Constanca Coelho, F. Azancoth. Genetics
Laboratory, Lisbon Medical School, Lisbon,
Portugal *CR
6027 — A0090 Anterior segment OCT study
of the pre-corneal film and its relationship with
dry-eye patient`s symptoms and quantitative
tests of the tear film. Maurizio Fossarello, P. E.
Napoli, G. M. Satta, F. Coronella. Ophthalmology,
University of Cagliari, Cagliari, Italy
6028 — A0091 Evaluation of the Standard
Patient Evaluation of Eye Dryness (SPEED)
Questionnaire. Nancy J. Keir 1 , W. Ngo 1 , P. Situ 5 , D.
R. Korb 3, 4 , C. A. Blackie 3, 4 , T. L. Simpson 2 . 1 School
of Optometry-CCLR, University of Waterloo,
Waterloo, ON, Canada; 2 School of Optometry and
Vision Science, University of Waterloo, Waterloo,
ON, Canada; 3 TearScience, Morrisville, NC; 4 Korb
Associates, Boston, MA; 5 School of Optometry,
Indiana University, Bloomington, IN *CR
6029 — A0092 Inhibition of Matrix
Metalloproteinases by Mapracorat, a Novel
Selective Glucocorticoid Receptor Agonist
(SEGRA), in Human Corneal Epithelial Cells.
Thomas R. Vollmer, K. L. Harrington, J. Zhang, M.
Richardson, M. E. Cavet. Preclinical Pharmacology,
Bausch + Lomb, Rochester, NY *CR
6030 — A0093 Histopathologic changes in
punctal stenosis. Gary J. Lelli 1 , A. D. Port 3 , Y.
Chen 2 . 1 Ophthalmology, Weill Cornell Medical
College, New York, NY; 2 Pathology and Laboratory
Medicine, Weill Cornell Medical College, New
York, NY; 3 Weill Cornell Medical College, New
York, NY
6031 — A0094 Hyperosmolar dryness stress
on 3D HCE model: a new tool for pre-clinical
assessment of tear substitutes. Barbara De Servi 1 ,
C. Olmiere 2 , M. Meloni 1 . 1 VitroScreen, Milan, Italy;
2
Laboratoires Thea, Clermont-Ferrand, France *CR
6032 — A0095 Ocular manifestations and
treatment outcomes of patients with graftversus-host
disease. Sankaranarayana Mahesh,
C. J. Rapuano, P. K. Nagra, K. M. Hammersmith.
Cornea, Wills Eye Institute, Phiiladelphia, PA
6033 — A0096 Thymosin Beta 4 Eye Drops
Significantly Improve Signs and Symptoms of
Severe Dry Eye in a Physician-Sponsored Phase
2 Clinical Trial. Gabriel Sosne 1 , S. P. Dunn 2 ,
D. Crockford 3 , C. Kim 1 , E. Dixon 3 . 1 Ophthal &
Anatomy & Cell Biol, Wayne State Univ Sch of
Med, Detroit, MI; 2 Michigan Cornea Consultants,
Southfield, MI; 3 RegeneRx Biopharmaceuticals,
Rockville, MD *CR, f
6034 — A0097 Biomarkers in the tear fluid
during chemical ocular injury in the rabbit
model.
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
378

Thursday – Posters – 6035 – 6057
6035 — A0098 Characterization of cultivated
Human Oral Mucosal Epithelial Cells (HOMEs)
in an autologous culture medium. Camilla Gram,
D. Krohn-Hansen, E. Gulliksen, K. Haug, J. K.
Slettedal, M. C. Moe, L. Drolsum, B. Nicolaissen,
A. Shahdadfar. Department of Ophthalmology, Oslo
University Hospital Oslo, Norway, Center for Eye
Research, Oslo, Norway
6036 — A0099 Effects of lens care solutions on
dynamic interfacial properties of human tear
lipids. Tatyana F. Svitova, M. C. Lin. Optometry
School, Univ of California, Berkeley, Berkeley, CA
*CR
6037 — A0100 Efficacy of long-term treatment
with diquafosol sodium for dry eye due to laser
in situ keratomileusis. Ryohei Nejima, Y. Mori,
A. Masuda, Y. Maruyama, K. Minami, K. Miyata.
Miyata Eye Hospital, Miyakonojyo, Japan
6038 — A0101 Effect of dynamic changes in
the tear film on the optical quality in normal
and dry eyes. Johan Hedström, B. Theagarayan.
Section of Optometry and Vision Science, Linnaeus
University, Kalmar, Sweden
6039 — A0102 Multidimensional scaling
of words used to characterize ocular surface
discomfort. Trefford L. Simpson, Y. Feng. School
of Optometry & Vision Science, University of
Waterloo, Waterloo, ON, Canada
6040 — A0103 Changes of Higher Order
Aberration depending on Ocular Surface
Indicators analyzed by Continuous Measurement
after Phacoemusification. Si-Hwan Choi, H. Lim.
chungnam national university hospital, department
of ophthalmology, daejeon, south korea, Daejeon,
Republic of Korea
6041 — A0104 Hyperosmolar conditions
Increase benzalkonium chloride (BAK) toxicity
in an in vitro cornea wound healing model and
an in vivo dry eye mouse model. Hong Liang 1, 2 ,
C. Baudouin 1, 2 , P. Daull 3 , J. Garrigue 3 , F. Brignole-
Baudouin 1, 2 . 1 Ophthalmology-Hosp Paris, CHNO
Des Quinze-Vights, Paris, France; 2 INSERM,
UMR_S968, Vision Institute, Paris, France;
3
Novagali Pharma, Evry, France *CR
6042 — A0105 Internal Standard Dilution
Indicator Protocol (ISDIP): A Newer Method for
the Quantitative Assessment in Tear Lipidomic
Studies. Anju Sirohiwal 1 , J. S. Titiyal 1 , S. P.
Garg 1 , S. Sen 1, 2 , S. Baskar Singh 1, 3 , S. Ghose 1 , T.
Velpandian 1, 4 . 1 Ophthalmology, All India Institute
of Medical Sciences, New Delhi, India; 2 Ocular
Pathology, All India IInstitute of Medical Sciences,
New Delhi, India; 3 Biophysics, All India IInstitute
of Medical Sciences, New Delhi, India; 4 Ocular
Pharmacology and Pharmacy, All India IInstitute of
Medical Sciences, New Delhi, India
6043 — A0106 Updated Fluorophotometry
Technique Correlates With Signs and Symptoms
of Dry Eye Better Than Schirmer’s Test. Colleen
Heckley 1 , E. Angjeli 1 , K. J. Lane 1 , C. Ahearn 1 , D. L.
Welch 2 , G. W. Ousler 2 . 1 R&D, Ora, Inc., Andover,
MA; 2 Ora, Inc., Andover, MA *CR
6044 — A0107 Effects of controlled heat
delivery to the eyelid margin & eyelid hygiene
on symptomatology and the tear film in MGD.
Michel Guillon 1, 2 , C. A. Maissa 1 , S. Wong 1 , A.
Lane 1 , B. Bossard 1 . 1 OTG Research & Consultancy,
London, United Kingdom; 2 School of Life and
Health Sciences, Aston University, Birmingham,
United Kingdom *CR
6045 — A0108 A Software-based Approach
for the Analysis of Lissamine Staining of the
Conjunctiva. Keith J. Lane, J. D. Rodriguez, E.
Angjeli, G. W. Ousler. Clinical R & D, Ora, Inc.,
Andover, MA *CR
6046 — A0109 Surgical Model for Evaporative
Loss Dry Eye Model in the New Zealand
White Rabbit. Anthony J. Johnson 1, 3 , P. Buttke 3 ,
I. E. Kochevar 2 , H. H. Wang 1 , S. R. Cora 1 , S. L.
DeMartelaere 3 . 1 Ocular Trauma Research, USAISR,
Fort Sam Houston, TX; 2 Wellman Center for
Photomedicine, Massachusetts General Hospital,
Boston, MA; 3 SAUSHEC Ophthalmology, San
Antonio Military Medical Center, Fort Sam
Houston, TX *CR
6047 — A0110 Clinical Correlations Among
Dry Eye Tests, Physical And Metabolic Findings
In Diabetes Mellitus Patients. Peter S. Reinach 1, 2 ,
J. F. Faustino 2 , M. Alves 2 , D. Ribeiro 2 , J. S. Paula 2 ,
E. M. Rocha 2 . 1 Biological Sciences, SUNY College
of Optometry, New York, NY; 2 Oftalmologia,
Otorrinolaringologia e Cirurgia de Cabeça e
Pescoço., Universidade de São Paulo, Ribeirão
Preto, Ribeirao Preto, Brazil
6048 — A0111 The Influence of Punctal
Occlusion on Osmolarity in Dry Eye Subjects.
David C. Eldridge, M. S. Berg, B. D. Sullivan, W. D.
Townsend. TearLab Corp, Bixby, OK *CR
6049 — A0112 Transcultural Validation
of McMonnies Questionnaire for Mexican
Population. Alejandro Babayan 1 , N. Ramos-
Betancourt 2 , F. Beltran 2 , J. D. Martinez 2 , C.
Santacruz Valdes 3 , C. Ramírez-Assad 2 , E. M.
Mora Juarez 2 , E. Hernandez-Quintela 2 . 1 Cornea,
Fundacion Hospital “Nuestra Senora de la Luz”,
Mexico City, Mexico; 2 Cornea, Asociación para
evitar la ceguera en Mexico, Mexico, Mexico;
3
Cornea, Instituto de Oftalmología Conde de
Valenciana, Mexico, Mexico
6050 — A0113 Transcultural Validation
of Ocular Surface Disease Index (OSDI)
Questionnaire for Mexican Population.
Francisco Beltran 1, 2 , N. Ramos-Betancourt 1, 2 ,
J. D. Martinez 1, 2 , C. Santacruz Valdes 3, 2 , A.
Babayan 4, 2 , C. Ramírez-Assad 2 , E. M. Mora Juarez 2 ,
E. Hernandez-Quintela 1, 2 . 1 Cornea, Asociación
Para Evitar la Ceguera en México, Mexico City,
Mexico; 2 Colegio de Investigación en Ciencias
Visuales, MARVO, Mexico City, Mexico; 3 Cornea,
Instituto de Oftalmología Conde De Valenciana,
Mexico City, Mexico; 4 Cornea, Hospital Fundación
“Nuestra Señora de la Luz”, Mexico City, Mexico
6051 — A0114 Anterior Segment Optical
Coherence Tomography changes of ocular
surface after topical anti-inflammatory therapy
in dry eyes. Pietro E. Napoli, M. Fossarello, F.
Coronella, G. M. Satta. Eye Clinic, University of
Cagliari, Cagliari, Italy
6052 — A0115 Use of Artificial Tears vs Cold
Compresses for the Treatment of Dry Eye.
Andrew A. Kao, R. Latkany. Ophthalmology, The
New York Eye and Ear Infirmary, New York City,
NY *CR, f
6053 — A0116 Long-Term Effects of Cataract
Surgery on Tear Film Parameters. Anat Galor 1, 2 ,
V. D. Venincasa 1 , W. J. Feuer 2 , H. Florez 1, 4 , D.
J. Lee 3 . 1 Miami Veterans Affairs Medical Center,
Miami, FL; 2 Ophthalmology, Bascom Palmer,
Miami, FL; 3 Department of Epidemiology and
Public Health, University of Miami, Miami, FL;
4
Department of Endocrinology and Geriatrics,
University of Miami, Miami, FL *CR
Exhibit Hall B0065-B0077
Thursday, May 09, 2013 10:30 AM-12:15 PM
Visual Psychophysics / Physiological Optics
536 Inner Retina and Blood Vessels
Moderators: Toco Y. Chui and Richard B. Rosen
6054 — B0065 Future Insights on an Ocular
Hypertension Model in the White Leghorn
Chicken. Jennifer L. Choi 1 , R. T. Tzekov 2, 3 , S.
S. Choi 1 . 1 New England College of Optometry,
Boston, MA; 2 The Roskamp Institute, Sarasota, FL;
3
Department of Ophthalmology, University of South
Florida, Tampa, FL
6055 — B0066 Detection of flow velocity
fluctuations associated with erythrocyte
aggregation in diabetic retinopathy by using
adaptive optics scanning laser ophthalmoscopy.
Akihito Uji, M. Hangai, S. Ooto, S. Arichika, T.
Murakami, N. Yoshimura. Ophthalmology, Kyoto
Univ Graduate Sch of Med, Kyoto City, Japan *CR
6056 — B0067 Adaptive contrast enhancement
in capillary shadow region of AOSLO images
using blood cell flow information. Hiroshi
Imamura 1 , T. Yuasa 1 , H. Sonobe 1 , A. Uji 2 , S. Ooto 2 ,
M. Hangai 2 , N. Yoshimura 2 . 1 Canon Inc, Ohta-ku,
Japan; 2 Ophthalmology, Kyoto University Graduate
School of Medicine, Kyoto City, Japan *CR
6057 — B0068 Study of epimacular membranes
using adaptative optics high resolution
imaging. Hassiba Bouakkaz 1 , S. Ayello-Scheer 1 ,
A. Leseigneur 1 , C. Devisme 1 , J. A. Sahel 1, 2 ,
M. Paques 1, 2 . 1 Centre Hospitalier National
d’Ophtalmologie des Quinze Vingts, Paris, France;
2
Institut de la Vision, Paris, France *CR
Thursday Posters
10:30 am – 12:15 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
379

6058 – 6075 – Thursday – Posters
Thursday Posters
10:30 am – 12:15 pm
6058 — B0069 Parietal morphometry of
retinal arterioles in health and hypertension
using adaptive optics. Edouard Koch 1, 2 , D.
Rosenbaumm 3 , X. Girerd 3 , F. Rossant 4 , M. Paques 1 .
1
Clinial Investigation Center, Quinze-Vingts
Hospital-INSERM, Paris, France; 2 Ophthalmology,
Versailles Hospital, Versailles, France; 3 Cardiology,
Pitié Salpétrière Hospital, Paris, France; 4 Institut
Supérieur d’Electronique de Paris, ISEP, Paris,
France *CR, f
6059 — B0070 Investigation of the
correlation among diameter of retinal vessel
and arteriosclerosis risk factors including
hypoadiponectinemia. Kei Homma 1 , R. Kawasaki 2 ,
Y. Tanabe 1 , K. Saito 1 , A. Sugano 1 , A. Hozawa 3 , K.
Takeo 4 , I. Kubota 5 , T. Kayama 6 , H. Yamashita 1 .
1
Ophthalmology, Yamagata Univ Sch of Medicine,
Yamagata, Japan; 2 Public Health, Yamagata Univ
Sch of Medicine, Yamagata, Japan; 3 Tohoku Univ
Sch of Medicine, Sendai, Japan; 4 Neurology,Hemat
ology,Metabolism,Endocrinology and Diabetology,
Yamagata Univ Sch of Medicine, Yamagata,
Japan; 5 Cardiology,Pulmonology,and Nephrology,
Yamagata Univ Sch of Medicine, Sendai, Japan;
6
Neurosurgery, Yamagata Univ Sch of Medicine,
Yamagata, Japan *CR
6060 — B0071 Noninvasive Imaging of Retinal
Pericytes and Endothelial Cells in Living Human
Eyes. Toco Y. Chui, T. Gast, S. A. Burns. Optometry,
Indiana University, Bloomington, IN
6061 — B0072 Adaptive Optics Measurements
of Retinal Arterial Wall Thickness in both
Normotensive and Hypertensive Subjects. Jake
Hillard 1 , T. Y. Chui 1 , D. A. Sapir 2 , T. Gast 1 , S. A.
Burns 1 . 1 School of Optometry, Indiana University,
Bloomington, IN; 2 Medical School, Indiana
University, Bloomington, IN
6062 — B0073 Distribution of vessels with
dark tails in the parafoveal capillary network
monitored by adaptive optics scanning laser
ophthalmoscopy. Shigeta Arichika, A. Uji, M.
Hangai, S. Ooto, N. Yoshimura. Kyoto University,
Kyoto, Japan *CR
6063 — B0074 In vivo imaging of Hypertensive
Retinopathy using Fluorescence Adaptive Optics
Scanning Light Ophthalmoscopy. Michael
Dubow 1, 2 , A. Pinhas 1, 2 , N. Shah 1 , Y. N. Sulai 3 , P.
Garcia 1 , N. K. Scripsema 4 , J. Carroll 5 , A. Dubra 5 , R.
B. Rosen 1 . 1 New York Eye and Ear Infirmary, New
York City, NY; 2 Mount Sinai School of Medicine,
Mount Sinai Hospital, New York City, NY;
3
University of Rochester, Rochester, NY; 4 New York
Medical College, Valhalla, NY; 5 Medical College of
Wisconsin, Milwaukee, WI *CR
6064 — B0075 Normal retinal vasculature
imaged using fluorescence adaptive optics
scanning light ophthalmoscopy (FAOSLO).
Nishit Shah 1 , M. Dubow 1, 2 , A. Pinhas 1, 2 , N. K.
Scripsema 1 , A. Dubra 3, 4 , Y. N. Sulai 6, 3 , D. H.
Scoles 5, 3 , R. B. Rosen 1 . 1 Ophthalmology, New York
Eye and Ear Infirmary, New York, NY; 2 Mount
Sinai Hospital, Mount Sinai School of Medicine,
New York, NY; 3 Ophthalmology, Medical College
of Wisconsin, Milwaukee, WI; 4 Biophysics,
Medical College of Wisconsin, Milwaukee, WI;
5
Biomedical Engineering, University of Rochester,
Rochester, NY; 6 The Institute of Optics, University
of Rochester, Rochester, NY *CR
6065 — B0076 Histopathologic Features
of Diabetic Microangiopathy Imaged
Using an Adaptive Optics Scanning Laser
Fluorescein Angiography. Richard B. Rosen 1, 2 ,
A. Dubra 3 , R. Weitz 1 , J. Carroll 3 , M. Dubow 1,
4
, A. Pinhas 1, 4 , N. Shah 1 , Y. N. Sulai 3, 5 , N. K.
Scripsema 1, 2 , J. B. Walsh 1, 2 . 1 Ophthalmology,
New York Eye & Ear Infirmary, New York, NY;
2
Ophthalmology, New York Medical College,
Valhalla, NY; 3 Ophthalmology, Medical College
of Wisconsin, Milwaukee, WI; 4 Ophthalmology,
Mount Sinai School of Medicine, New York,
NY; 5 Ophthalmology, University of Rochester,
Rochester, NY *CR
6066 — B0077 Microangiopathic Features
of Central Retinal Vein Occlusion Imaged
Using Fluorescence Adaptive Optics Scanning
Light Ophthalmoscopy. Alexander Pinhas 1, 2 , N.
Shah 1 , M. Dubow 1, 2 , M. Mehta 1 , P. Garcia 1 , N. K.
Scripsema 1, 3 , J. Carroll 4, 5 , Y. N. Sulai 6 , A. Dubra 4, 7 ,
R. B. Rosen 1 . 1 Ophthalmology, New York Eye and
Ear Infirmary, New York, NY; 2 Mount Sinai School
of Medicine, New York, NY; 3 New York Medical
College, Valhalla, NY; 4 Ophthalmology, Medical
College of Wisconsin, Milwaukee, WI; 5 Cell
Biology, Neurology and Anatomy, Medical College
of Wisconsin, Milwaukee, WI; 6 The Institute
of Optics, University of Rochester, Rochester,
NY; 7 Biophysics, Medical College of Wisconsin,
Milwaukee, WI *CR
Exhibit Hall B0138-B0179
Thursday, May 09, 2013 10:30 AM-12:15 PM
Retinal Cell Biology / Visual Neuroscience
537 Cell Biology of the Retina and
RPE II
Moderator: Peter F. Hitchcock
6067 — B0138 Increasing body weight
correlates with loss of ERG in mice with Bardet
Biedl Syndrome. Arlene V. Drack 1 , S. Bhattarai 1 ,
E. M. Stone 1 , K. Wang 3 , D. Gratie 1 , E. Heon 2 , V. C.
Sheffield 1 , R. F. Mullins 1 . 1 Ophthalmology, Univ of
Iowa Hospitals, Iowa City, IA; 2 Ophthalmology,
Sickkids Toronto, Toronto, ON, Canada;
3
Biostatistics, University of Iowa, Iowa City, IA
*CR
6068 — B0139 Enforced Expression of Snail
Gene Resulted in Retinal Pigment Epithelial-
Mesenchymal Transition. Hui Li, F. Wang, M.
Li. Tenth People’s Hospital of Tongji University,
Shanghai, China
6069 — B0140 Effects of thrombin on tight
junction-associated molecules in polarized RPE
cells. Hiroto Terasaki, M. Shirasawa, H. Otsuka, S.
Sonoda, T. Sakamoto. Ophthalmology, Kagoshima
University, Kagoshima, Japan
6070 — B0141 Retinal changes in
Hemiparkinson rat. Soon Il Kwon 1 , C. Cho 2 , I.
Kim 3 . 1 ophthalmology, HALLYM Sacred heart
HOSPITAL, Hallym University, Anyang, Republic
of Korea; 2 neurosurgery, HALLYM Sacred heart
HOSPITAL, Hallym University, Anyang, Republic
of Korea; 3 Anatomy, College of Medicine, The
Catholic University of Korea, Seoul, Republic of
Korea
6071 — B0142 Iron Upregulates Melanogenesis
Genes in the RPE. Natalie Wolkow 1 , A.
Maminishkis 4 , J. Iacovelli 3 , J. C. Lee 2 , S. S.
Miller 4 , J. L. Dunaief 1 . 1 Scheie Eye Institute, The
Raymond and Ruth Perelman School of Medicine
at the University of Pennsylvania, Philadelphia,
PA; 2 Pennsylvania College of Optometry, Salus
University, Elkins Park, PA; 3 Schepens Eye
Research Institute, Harvard Medical School,
Boston, MA; 4 National Eye Institute, National
Institutes of Health, Bethesda, MD *CR
6072 — B0143 The Role of Glucocorticoid
Receptor Signaling in Normal and Damaged
Avian Retina. Donika Gallina, A. J. Fischer. The
Ohio State University, Columbus, OH
6073 — B0144 Polyvinyl Alcohol-based
Encapsulation of Müller Cells Improves Release
of Brain-Derived Neurotrophic Factor. Yuko
Shinohara, M. Takii, T. Nakamura, M. Nakatani, K.
Ohtsuki. Bioengineering Institute, NIDEK Co Ltd,
Gamagori, Japan *CR
6074 — B0145 AMPK-NF-κB axis modulates
visual function during inflammation. Mamoru
Kamoshita 1 , S. Kubota 1 , K. Yuki 1 , S. Miyake 1 , N.
Nagai 1 , K. Umezawa 2 , K. Tsubota 1 , Y. Ozawa 1 .
1
Ophthalmology, Keio University School of
Medicine, Shinjyuku, Japan; 2 Molecular Target
Medicine Screening, Aichi Medical University
School of Medicine, Nagakute, Japan *CR
6075 — B0146 Elastin-like polypeptide (ELP)
fused to an αB crystallin mini-chaperone protects
RPE cells from oxidant injury. Parameswaran
G. Sreekumar 1 , W. WANG 2 , J. A. MacKay 2 , C.
Spee 3 , S. J. Ryan 1, 3 , R. Kannan 1, 3 , D. R. Hinton 4, 1 .
1
Arnold and Mabel Beckman Macular reserach
Center, Doheny Eye Institute, Los Angeles, CA;
2
Pharmacology and Pharmaceutical Sciences,
University of Southern California, Los Angeles,
CA; 3 Ophthalmology, Keck School of Medicine of
the University of Southern California, Los Angeles,
CA; 4 Pathology, Keck School of Medicine of the
University of Southern California, Los Angeles,
CA *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
380

Thursday – Posters – 6076 – 6096
6076 — B0147 Rod and Cone Photoreceptors
in the Mouse Retina Express Cfh. Sharon L.
Oltjen 1 , J. Estep 2 , P. G. FitzGerald 2 , Q. Gong 2 ,
L. M. Hjelmeland 1 . 1 Ophthalmology, University
of California-Davis, Davis, CA; 2 Cell Biology &
Human Anatomy, University of California-Davis,
Davis, CA *CR
6077 — B0148 Disruption of cell-cell junctions
and induction of pathological cytokines in the
retinal pigment epithelium of light-exposed
mice. Toshio Narimatsu 1, 2 , S. Miyake 1 , S. Kubota 3 ,
M. Hirasawa 2 , N. Nagai 1, 2 , K. Tsubota 2 , Y.
Ozawa 1, 2 . 1 Laboratory of Retinal Cell Biology,
Keio University School of Medicine, Shinjukuku,
Japan; 2 Department of Ophthalmology, Keio
University School of Medicine, Shinjuku-ku, Japan;
3
Ophthalmology and Visual Science, Washington
University School of Medicine in St.Louis, St.
Louis, MO *CR
6078 — B0149 Age-Dependent Ocular Changes
in Sirt6 Knockout Mice. Alexey Obolensky 1 , V.
Peshti 2 , Y. Kanfi 2 , H. Y. Cohen 2 , E. Banin 1 . 1 Center
for Retinal and Macular Degenerations, Department
of Ophthalmology, Hadassah-Hebrew University
Medical Center, Jerusalem, Israel; 2 The Mina and
Everard Goodman Faculty of Life Sciences, Bar-
Ilan University, Ramat-Gan, Israel
6079 — B0150 Hyaluronan and Tissue
Inhibitor of Metalloproteinases-3 in Sorsby’s
Fundus Dystrophy and AMD. Alecia Cutler 1 ,
B. Anand-Apte 1 , V. L. Bonilha 1 , D. Hatipoglu 1 , H.
Stoehr 2 . 1 Ophthalmic Research, Cleveland Clinic
Foundation, Cleveland, OH; 2 Institute of Human
Genetics, University of Regensburg, Regensburg,
Germany *CR
6080 — B0151 Best Vitelliform Macular
Dystrophy Mutants Oligomerize with Wild Type
Bestrophin-1 and Exhibit Differential Effects
on Protein Trafficking. Adiv A. Johnson 1 , Y.
Lee 1 , K. Yu 4 , C. H. Hartzell 4 , L. Y. Marmorstein 1, 2 ,
A. D. Marmorstein 1, 3 . 1 Ophthalmology and
Vision Science, University of Arizona, Tucson,
AZ; 2 Department of Physiology, University of
Arizona, Tucson, AZ; 3 College of Optical Sciences,
University of Arizona, Tucson, AZ; 4 Department
of Cell Biology and Center for Neurodegenerative
Disease, Emory University, Atlanta, GA
6081 — B0152 Paraoxonase-1 (PON1) in
retinal physiology and pathophysiology.
Jadwiga Oczos 1, 2 , B. Kloeckener-Gruissem 2, 4 ,
W. Berger 2, 3 , C. Grimm 1, 3 . 1 Lab for Retinal Cell
Biology, Department of Ophthalmology, University
of Zurich, Zurich, Switzerland; 2 Institute of
Medical Molecular Genetics, University of Zurich,
Schwerzenbach, Switzerland; 3 Zurich Center for
Integrative Human Physiology (ZIHP), University
of Zurich, Zurich, Switzerland; 4 Department of
Biology, ETH Zurich, Zurich, Switzerland
6082 — B0153 Structural and Functional
Properties of Photoreceptor Mitochondria in
Awake and Hibernating Ground Squirrels. Talia
R. Kaden 1, 2 , J. Du 1 , A. R. Goel 1 , D. Lu 1 , W. Li 1 .
1
Retinal Neurophysiology, NEI, Bethesda, MD;
2
Yale University School of Medicine, New Haven,
CT
6083 — B0154 Cross-talk Between Retinal
Pigment Epithelial Cells and Mast Cells via
Secreted Mediators, Especially Mast Cell
Tryptase. Rei Wakasa 1 , H. Kawano 2 , A. Matsuda 2 ,
H. Ushio 3 , T. Sakuma 1 , A. Murakami 2 , N. Ebihara 1 .
1
Ophthalmology, Juntendo Uneversity Urayasu
Hospital, Urayasu City, Japan; 2 Ophthalmology,
Juntendo University School of Medicine, Bunkyoku,
Japan; 3 Allergy Research Center, Juntendo
Uneversity School of Medicine, Bunkyo-ku, Japan
*CR
6084 — B0155 Expression of RPE primary cilia
in adult mice. Guillermo L. Lehmann-Mántaras, R.
Schreiner, E. de la Fuente, E. J. Rodriguez-Boulan.
Ophthalmology, Weill Cornell Medical College,
New York, NY
6085 — B0156 Involvement of LC3-dependent
phagocytosis and MREG in the degradation of
disk membranes by the RPE. Kathleen Boesze-
Battaglia 1 , F. P. Stefano 1 , V. S. Lopes 3 , A. Bragin 1 ,
B. Jun 4 , W. C. Gordon 4 , I. R. Rodriguez 2 , N. G.
Bazan 4 , D. S. Williams 3 , L. S. Frost 1 . 1 Biochemistry,
University of Pennsylvania, Philadelphia, PA;
2
National Eye Institute, Bethesda, MD; 3 Jules
Stein Eye Institute- UCLA School of Medicine,
Los Angeles, CA; 4 Neuroscience, LSUHNO, New
Orleans, LA
6086 — B0157 Flow Cytometry Approach
to Study NGF and p75 in Retinal Cells from
Reeler mice. Bijorn O. Balzamino 1 , R. Marino 2 ,
G. Esposito 1 , F. Biamonte 3 , F. Keller 2 , A. Micera 1 .
1
Lab Ophthalmology, IRCCS GB Bietti Foundation,
Rome, Italy; 2 Laboratory of Developmental
Neuroscience and Neural Plasticity, University
Campus Bio-Medico, Rome, Italy; 3 Institute of
Histology and Embryology, Catholic University of
the Sacred Heart “A. Gemelli”, Rome, Italy
6087 — B0158 Spinules of cone horizontal
cells in European sea bass are more numerous
in the dorsal and nasal peripheral retina. Are
spinules biological detectors to peripheral vision
of teleosts? Joaquin De Juan, B. Boughlala, N.
Martinez-Ruiz. Dept Biotecnologia, Universidad de
Alicante, San Vicente del Raspeig, Spain
6088 — B0159 Functional and molecular
characterization of ex vivo cultured neuronaland
glial- like cells from internal limiting
membrane. Xhevat Lumi 1 , S. Andjelic 1 , E. Johnsen 2 ,
M. Moe 2 , M. Hawlina 1 , G. Petrovski 1, 3 . 1 Eye
Hospital, University Medical Centre, Ljubljana,
Slovenia; 2 Centre for Eye Research,Department
of Ophthalmology, Oslo University Hospital and
University of Oslo, Oslo, Norway; 3 Stem Cells
and Eye Research Laboratory, Departments of
Ophthalmology and Biochemistry and Molecular
Biology, Medical and Health Science Center,
University of Debrecen, Debrecen, Hungary
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
381
6089 — B0160 Hypertension-induced Ang II
promotes tube formation via MCP-1/MCPIP
induction. Maria E. Marin Castano 1 , W. Lee 1 , E.
P. Hernandez 1 , F. Praddaude 2 , C. Pecher 2 , S. W.
Cousins 3 . 1 Ophthalmology, University of Miami,
Miami, FL; 2 Physiology and Pharmacology,
University Paul Sabatier/INSERM-U 338, Toulouse,
France; 3 Ophthalmology, Duke University Eye
Center, Durham, NC *CR
6090 — B0161 Inflammation Exacerbates
Hydroxychloroquine-Induced Retinotoxicity
in Human Retinal Pigment Epithelial Cells.
Matthew G. Trese 1, 2 , Y. Li 1 , H. Gao 1 , X. Qiao 1 .
1
Department of Ophthalmology, Henry Ford Health
System, Detroit, MI; 2 Michigan State University,
College of Osteopathic Medicine, Detroit, MI
6091 — B0162 A synaptic scaffold complex
unique to horizontal cell processes contacting
photoreceptors. Alejandro Vila 1, 2 , C. M. Whitaker 1 ,
J. O’Brien 1, 2 . 1 Dept. of Ophthalmology & Visual
Science, Houston, TX; 2 The University of Texas
Graduate School of Biomedical Sciences, Houston,
TX
6092 — B0163 A Surface Proteome of Primary
Fetal Human RPE Cells. Jason Silver 1 , D. R.
Riordon 2 , F. Hua 1 , O. S. Memon 1 , A. Maminishkis 1 ,
R. L. Gundry 3 , S. S. Miller 1 , K. R. Boheler 2 , K.
Bharti 1 . 1 National Eye Institute, National Institutes
of Health, Bethesda, MD; 2 National Institute of
Aging, National Institutes of Health, Bethesda, MD;
3
Medical College of Wisconsin, Milwaukee, WI
6093 — B0164 The Role of 7-Ketocholesteryl
Esters on 7KCh-Mediated Cytotoxicity and
Inflammation in ARPE-19 cells. Jung W. Lee, J.
Huang, I. R. Rodriguez. Mechanisms of Retinal
Diseases Section, LRCMB, National Eye Institute/
NIH, Bethesda, MD
6094 — B0165 Blockade of Vascular
Endothelial Protein Tyrosine Phosphatase:
A Novel Approach to Stabilizing the Retinal
Vasculature. Ji-kui Shen 1 , P. A. Campochiaro 1 ,
C. Seidel 1 , A. Dong 1 , M. Frye 2 , J. McClung 3 , S. F.
Hackett 1 , B. Howard 4 , D. Vestweber 2 , K. Peters 5 .
1
Ophthalmology, Wimer Eye Institute, Baltimore,
MD; 2 Department of Cell Biology, Max-Planck-
Institute of Molecular Biomedicine, Muenster,
Germany; 3 Department of Medicine, Division
of Cardiology Duke University Medical Center
Durham, Durham, NC; 4 Procter & Gamble,
Cincinnati, OH; 5 Aerpio Therapeutics, Cincinnati,
OH *CR
6095 — B0166 Optical Coherence Tomography
(OCT) and histologic examination of a mouse
model of chorioretinal coloboma. Sajag Bhattarai,
D. Gratie, M. Stunkel, M. G. Anderson, R. F.
Mullins, A. V. Drack. University of Iowa, Iowa City,
IA *CR
6096 — B0167 Life and Death of Retinal Cells
in Optic Nerve Sectioned Chick Eyes. Stacey
Chong 1 , C. F. Wildsoet 2 , V. Choh 1 . 1 Vision Science,
University of Waterloo, Waterloo, ON, Canada;
2
School of Optometry, University of California,
Berkeley, Berkeley, CA
Thursday Posters
10:30 am – 12:15 pm

6097 – 6115 – Thursday – Posters
Thursday Posters
10:30 am – 12:15 pm
6097 — B0168 Physical support of the inner
retina enhances cell survival in adult porcine
retinal explants. Linnea T. Taylor, K. M. Arner,
I. Holmgren Taylor, F. K. Ghosh. Ophthalmology,
Lund University, Lund, Sweden
6098 — B0169 Potential phototoxicity of
indocyanine green in retinal pigment epithelial
cells after its angiography. Tomohito Sato 1 , Y.
Karasawa 1 , S. Ishikawa 1 , M. Taguchi 1 , T. Muraoka 1 ,
M. Ito 2 , M. Takeuchi 1 . 1 Ophthalmology, National
Defense Medical College, Tokorozawa, Japan;
2
Developmental Anatomy and Regenerative
Biology, National Defense Medical Collage,
Tokorozawa, Japan
6099 — B0170 Differential overexpression of
Homer 1 isoforms is associated with hallmarks
of disease and decline in visual performance
in a preclinical model of glaucoma. Simon
Kaja 1 , Y. Naumchuk 1 , S. L. Grillo 1 , P. K. Borden 1 ,
P. Koulen 1, 2 . 1 Ophthalmology / Vision Research
Center, Univ of Missouri-Kansas City, Kansas City,
MO; 2 Basic Medical Science, Univ of Missouri-
Kansas City, Kansas City, MO
6100 — B0171 Activation of the retinal
renin angiotensin system via beta-adrenergic
stimulation of renin expression in the RPE. Olaf
Strauss 1 , V. T. Todorov 2 , J. Stindl 3 , J. R. Martins 4 .
1
Experimental Ophthalmology, Charite, University
Medicine, Eye Hospital, Berlin, Germany;
2
Nephrology, Inner Medicine III, University Carl
Gustav Carus, Dresden, Germany; 3 Experimental
Ophthalmology, Eye Hospital, University Medicine
Regensburg, Regensburg, Germany; 4 Institute
of cellular and molecular pharmacology, Sophia
Antipolis University of Nice, Nice, France
6101 — B0172 Characterization of the
blue light toxicity spectrum on A2E-loaded
RPE cells in sunlight normalized conditions.
Emilie Arnault 1, 2 , C. Barrau 3 , C. Nanteau 1, 2 , P.
Gondouin 1, 2 , V. Fontaine 1, 2 , T. Villette 3 , J. A. Sahel 2
4
, S. A. Picaud 1, 2 . 1 Institut de la Vision, U968,
INSERM, Paris, France; 2 Institut de la Vision,
UMR_S968, UPMC Université Paris 06, Paris,
France; 3 Essilor International, Paris, France; 4 Centre
Hospitalier National d’Ophtalmologie des Quinze-
Vingts, Paris, France *CR
6102 — B0173 Increased Levels of DJ-1 are
present in cells exposed to carboxyethylpyrrole
(CEP), and in Retina, RPE, Bruch’s Membrane
and Drusen from AMD donor eyes. Vera L.
Bonilha, M. E. Rayborn, X. Yang, K. G. Shadrach,
J. G. Hollyfield. Ophthalmology, Cole Eye Inst/
Cleveland Clin Lerner Ctr, Cleveland, OH
6103 — B0174 Mechanisms of VEGF
upregulation in human RPE cells: Role of
oxidized phospholipids and the ATF4 arm of the
unfolded protein response. Andreas Pollreisz 1 ,
T. Afonyushkin 2 , O. V. Oskolkova 2 , F. Gruber 3 , V.
N. Bochkov 2 , U. Schmidt-Erfurth 1 . 1 Department
of Ophthalmology, Medical University Vienna,
Vienna, Austria; 2 Department of Vascular Biology
and Thrombosis Research, Medical University
Vienna, Vienna, Austria; 3 Department of
Dermatology, Medical University Vienna, Vienna,
Austria *CR
6104 — B0175 Epithelial Membrane Protein
2 (EMP2) Modulates VEGF During Hypoxia in
ARPE-19 Cells. Ann M. Chan 1 , S. A. Morales 1 , Y.
Qin 1 , M. Wadehra 2 , L. K. Gordon 1 . 1 Jules Stein Eye
Institute, University of California, Los Angeles, Los
Angeles, CA; 2 Pathology and Laboratory Medicine,
University of California, Los Angeles, Los Angeles,
CA *CR
6105 — B0176 Identification of Interacting
Protein Partners of TOPORS in the Retina.
Barbara Czub 1 , A. Z. Shah 1 , G. Alfano 1 , L. Valdés
Sánchez 2 , C. Chakarova 1 , S. S. Bhattacharya 1, 2 .
1
Genetics, UCL Institute of Ophthalmology,
London, United Kingdom; 2 Cellular Therapy and
Regenerative Medicine, Andalusian Centre for
Molecular Biology and Regenerative Medicine
(CABIMER), Seville, Spain f
6106 — B0177 Conditional Depletion of Retinal
VLC-PUFAs Causes Retinal Dysfunction.
Martin-Paul G. Agbaga 1, 4 , B. Hopiavuori 3, 4 , F.
Li 1, 4 , J. McRae 1, 4 , R. S. Brush 1, 4 , M. A. Mandal 1, 3 ,
L. D. Marchette 1, 2 , M. H. Elliott 1, 3 , R. Ayyagari 5 ,
R. E. Anderson 1, 2 . 1 Ophthalmology, Univ of
Oklahoma Hlth Sci Ctr, Oklahoma City, OK; 2 Cell
Biology, University of Oklahoma Health Sciences
Center, Oklahoma City, OK; 3 Oklahoma Center
for Neuroscience, University of Oklahoma Health
Sciences Center, Oklahoma City, OK; 4 Dean McGee
Eye Institute, Oklahoma City, OK; 5 ophthalmology,
Shiley Eye Center, University of California, San
Diego, CA *CR
6107 — B0178 Inhibition of retinoblastoma
tumor progression using catalytic antioxidant
naoparticles. Kathryn E. Klump 1 , R. Towner 3, 1 ,
S. Seal 6, 5 , M. Dyer 4 , J. F. McGinnis 2, 1 . 1 Oklahoma
Ctr for Neuroscience, Univ of Oklahoma Hlth
Sciences Ctr, Oklahoma City, OK; 2 Cell Biology,
Ophthalmology, Univ of Oklahoma Hlth Sciences
Ctr, Oklahoma City, OK; 3 Oklahoma Medical
Research Foundation, Oklahoma City, OK;
4
Developmental Neurobiology, St. Jude Children’s
Research Hospital, Memphis, TN; 5 Mechanical
Materials and Aerospace Engineering, University
of Central Florida, Orlando, FL; 6 Nanoscience and
Technology Ctr, University of Central Florida,
Orlando, OK *CR
6108 — B0179 Independent roles of methionine
sulfoxide reductase A in mitochondrial ATP
synthesis and in protection from oxidative stress
of the retinal pigment epithelium. Silvia C.
Finnemann, J. Vargas, Y. Dun. Biological Sciences,
Fordham University, Bronx, NY
Exhibit Hall B0180-B0189
Thursday, May 09, 2013 10:30 AM-12:15 PM
Biochemistry/Molecular Biology
538 Apoptosis and Cell Stress
Moderator: Nichole D. Joachim
6109 — B0180 Rag1 expression in RGCs
is involved in programmed cell death. Takao
Hirano 1 , T. Hayashi 2 , T. Murata 1 . 1 Depart of
Ophthalmology, Shinshu University, Matsumoto,
Japan; 2 Department of Molecular and Cellular
Immunology, Shinshu University, Matsumoto,
Japan
6110 — B0181 Apoptotic retinal ganglion cell
death in an autoimmune glaucoma model is
accompanied by antibody depositions. Stephanie
C. Joachim 1 , C. Mondon 1 , S. Kuehn 1 , S. Reinehr 1 , F.
H. Grus 2 , B. H. Dick 1 . 1 Experimental Eye Research
Institute, Ruhr University, Bochum, Germany;
2
Experimental Ophthalmology, University Medical
Center, Mainz, Germany
6111 — B0182 Epigenetic Regulation of Rod
Photoreceptor Development. Sarah Cheng, H.
Yang, A. Swaroop. N-NRL, Bldg 6, National Eye
Institute, Bethesda, MD
6112 — B0183 Histone Deacetylase 3 (HDAC3)
plays an important role in retinal ganglion
cell death after acute optic nerve injury.
Heather Schmitt 1, 2 , C. Schlamp 1 , R. W. Nickells 1 .
1
Ophthalmology and Visual Sciences, University
of Wisconsin-Madison, Madison, WI; 2 Cellular and
Molecular Pathology, University of Wisconsin-
Madison, Madison, WI
6113 — B0184 Dicer is required for survival
of mature rod photoreceptors. Thomas
Sundermeier 1 , N. Zhang 1 , D. Mustafi 1 , H. Kohno 2 , K.
Palczewski 1 . 1 Pharmacology, Case Western Reserve
University, Cleveland, OH; 2 Ophthalmology and
Visual Sciences, Case Western Reserve University,
Cleveland, OH *CR
6114 — B0185 Transient Upregulation and
then Downregulation of BACE 1 and PS-1
in ER Stress Induced Apoptosis of Retinal
Ganglion Cells in vitro. Bingqian Liu, J. Ge. State
Key Laboratory of Ophthalmology, Zhongshan
Ophthalmic Center, Sun Yat-sen University,
Guangzhou, China
6115 — B0186 Progranulin Mutant Mice
Exhibit Accumulation of Intraneuronal
Lipofuscin Aggregates in the Retina. Brian
P. Hafler 1 , Z. A. Klein 2 , S. Strittmatter 2 .
1
Ophthalmology and Visual Science, Yale School
of Medicine, New Haven, CT; 2 Program in Cellular
Neuroscience, Neurodegeneration, and Repair, Yale
School of Medicine, New Haven, CT
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
382

Thursday – Posters – 6116 – 6138
6116 — B0187 C1qa deficiency exacerbates
RGC loss in a mouse glaucoma model. Qiong
Ding 1 , M. G. Anderson 2 , A. Cook 1 , M. H. Kuehn 1 .
1
Ophthalmology and Visual Sciences, U of
Iowa, Iowa City, IA; 2 Molecular Physiology and
Biophysics, U of Iowa, Iowa City, IA
6117 — B0188 Unveiling the retina’s realm
with retinal oxygenation. Veronica A. Kon
Graversen, M. Landers. Retina, University of North
Carolina at Chapel Hill, Chapel Hill, NC
6118 — B0189 RNA Structure-Function Issues
in Realizing Catalytically-Active Hammerhead
Ribozymes in Cells. Jack M. Sullivan 1, 2 ,
T. A. Kolniak 3 . 1 Research Service, Veterans
Administration Western NY Healthcare System,
Buffalo, NY; 2 Ophthalmology, Pharm/Tox, Phys/
Biopys, SUNY Eye Institute, SUNY at Buffalo,
Buffalo, NY; 3 Program in Neuroscience, SUNY at
Buffalo, Buffalo, NY *CR
Exhibit Hall B0190-B0215
Thursday, May 09, 2013 10:30 AM-12:15 PM
Visual Neuroscience / Visual Psychophysics /
Physiological Optics
539 Advancing Functional Assessment
of the Visual System
Moderator: Paul J. DeMarco
6119 — B0190 L:M Cone Ratio of Japanese
Derived with ERG Flicker Photometry Method.
Yasuki Yamauchi 1 , K. Yatsu 1 , J. A. Kuchenbecker 2 ,
M. Neitz 2 , J. Neitz 2 . 1 Dept. Informatics,
Yamagata University, Yonezawa, Japan; 2 Dept.
Ophthalmology, University of Washington Medical
School, Seattle, WA *CR
6120 — B0191 Change in Flash
Electroretinogram Morphology from Scotopic
to Photopic Conditions. Kate A. Godwin, P.
J. DeMarco. Psychological & Brain Sciences,
University of Louisville, Louisville, KY
6121 — B0192 Dark-adapted 15-Hz Flicker
Electroretinograms Measured With Rodisolating
Stimuli. Swetha Dhanireddy 1 , J. C. Park 2 ,
P. R. Nolan 2 , D. Cao 2 , J. McAnany 2 . 1 American
University of Antigua, St. Johns, Antigua and
Barbuda; 2 Ophthalmology and Visual Sciences,
University of Illinois at Chicago, Chicago, IL
6122 — B0193 Recovery of human rod
photoreceptors following prolonged illumination,
assessed using the electroretinogram. Omar A.
Mahroo 1, 2 , R. Sakalauskaite 2 , C. J. Hammond 1 ,
T. D. Lamb 3 . 1 Ophthalmology, King’s College
London, London, United Kingdom; 2 Physiology,
Development and Neuroscience, University
of Cambridge, Cambridge, United Kingdom;
3
Department of Neuroscience, John Curtin School
of Medical Research and ARC Centre of Excellence
in Vision Science, Australian National University,
Canberra, ACT, Australia
6123 — B0194 The Spatial Distribution of
L- and M-Cone Driven ERGs Reflecting Parvoand
Magnocellular Activity. Bruno D. Gomes 1 ,
G. S. Souza 1, 2 , M. D. Filho 1 , G. Pangeni 3 , L. L.
Silveira 1, 2 , J. J. Kremers 3 . 1 Instituto de Ciencias
Biologicas, Universidade Federal do Para, Belem,
Brazil; 2 Nucleo de Medicina Tropical, Univerdidade
Federal do Para, Belem, Brazil; 3 Department of
Ophthalmology, University Hospital Erlangen,
Erlangen, Germany
6124 — B0195 High throughput testing of
absolute behavioral threshold in mice. Charles
P. Ratliff, L. Faktorovich, A. P. Sampath. Zilkha
Neurogenetic Institute, University of Southern
California, Los Angeles, CA
6125 — B0196 Electrical measurements
of pigment bleaching in vivo. Christopher
Kessler 1 , E. N. Pugh 1, 2 , M. E. Burns 1, 3 . 1 Center
for Neuroscience, UC Davis, Davis, CA; 2 Human
Anatomy and Cell Biology, UC Davis, Davis, CA;
3
Ophthalmology & Vision Science, UC Davis,
Davis, CA
6126 — B0197 Contributions of Non-Visual
Sensory Signals to the Murine Flash ERG.
Naoyuki Tanimoto 1 , V. Sothilingam 1 , G. Gloeckner 1 ,
E. Bryda 2 , P. Humphries 3 , M. Biel 4 , M. W. Seeliger 1 .
1
Division of Ocular Neurodegeneration, Institute for
Ophthalmic Research, Centre for Ophthalmology,
Tuebingen, Germany; 2 Department of Veterinary
Pathobiology, College of Veterinary Medicine,
University of Missouri, Columbia, MO; 3 Ocular
Genetics Unit, Trinity College Dublin, Dublin,
Ireland; 4 Department of Pharmacy, Center for
Integrated Protein Science Munich, Ludwig-
Maximilians Universitaet Muenchen, Munich,
Germany
6127 — B0198 Impact of the spectral output
of “white” LEDs on the murine flash ERG.
Mathias W. Seeliger 1 , K. Narfstrom 2 , N. Tanimoto 1 .
1
Div of Ocular Neurodegeneration, Ctr Ophthal Inst
Ophthalmic Rsrch, Tuebingen, Germany; 2 Dept
of Vet Med & Surgery, University of Missouri,
Columbia, MO
6128 — B0199 Comparison of transretinal
mouse rod ERG with local ERG across
photoreceptor outer segments. Teemu T. Turunen,
A. O. Koskelainen. Department of Biomedical
Engineering and Computational Science, Aalto
University School of Science, Espoo, Finland
6129 — B0200 Adapting Commercial In
Vivo Electroretinogram System for Ex Vivo
Recordings. Vladimir J. Kefalov, F. Vinberg.
Ophthalmology & Visual Sciences, Washington
University School of Medicine, Saint Louis, MO
6130 — B0201 Voltage-gated sodium
channels amplify both light and dark adapted
electroretinograms in mice. Ben Smith, P. D. Cote,
F. Tremblay. Dalhousie University, Halifax, NS,
Canada
6131 — B0202 Binocular pattern
electroretinograms in the mouse. Tsung-Han
Chou 1, 2 , J. A. Toft-Nielsen 2 , J. E. Bohorquez 2 , O.
Ozdamar 2 , V. Porciatti 1 . 1 Bascom Palmer Eye Inst,
Univ of Miami, Miller Sch of Med, Miami, FL;
2
Biomedical Engineering, University of Miami,
Miami, FL
6132 — B0203 Recording and Manipulation
of the Pattern Electroretinogram in a Mouse
Eyecup Preparation. Eric C. Gustafson, A.
L. Silberschmidt, M. Esguerra, R. F. Miller.
Neuroscience, University of Minnesota,
Minneapolis, MN
6133 — B0204 Spatial differences in corneal
potentials in healthy rat eyes evaluated with
multi-electrode electroretinography (meERG).
John R. Hetling, H. Tajalli, Y. Krakova, Z. Derafshi.
Bioengineering, University of Illinois at Chicago,
Chicago, IL *CR
6134 — B0205 Multifocal Electroretinography
with simultaneous fundus imaging in mice.
R Michael Dutescu 1 , S. Skosyrski 1 , N. Kociok 1 ,
I. Semkova 1 , S. Mergler 1 , J. Atorf 2 , A. M.
Joussen 1 , J. J. Kremers 2 . 1 Ophthalmology,
Charité-Universitätsmedizin, Berlin, Germany;
2
Ophthalmology, University Hospital Erlangen,
Erlangen, Germany *CR
6135 — B0206 Topography and aging of
the scotopic mfERG. Athanasios Panorgias 1 ,
E. E. Sutter 2 , J. S. Werner 1, 3 . 1 Ophthalmology &
Vision Science, University of California Davis,
Sacramento, CA; 2 Electro-Diagnostic Imaging Inc,
Redwood City, CA; 3 Neurobiology, Physiology and
Behavior, University of California Davis, Davis,
CA *CR
6136 — B0207 Slow flash multifocal
electroretinograms in the foveola. Yoshiaki
Shimada 1 , A. Nakamura 2 , A. Tanikawa 2 , M.
Horiguchi 2 . 1 Ophthalmology, Fujita Health Univ
Banbuntane Hosp, Nagoya, Japan; 2 Ophthalmology,
Fujita Health Univ School of Medicine, Toyoake,
Japan
6137 — B0208 Validation of a Novel Fast and
Robust Automated Technique for Calculation of
the EOG Arden Ratio, Using R. Marc Sarossy 1, 3 ,
M. H. Lee 2 , M. Bach 4 . 1 ODC, Royal Victorian Eye
and Ear Hospital, East Melbourne, VIC, Australia;
2
Faculty of Medicine, Nursing and Health Sciences,
Monash University, Clayton, VIC, Australia;
3
CERA, University of Melbourne, Melbourne, VIC,
Australia; 4 Universitäts-Augenklinik, Freiburg,
Germany
6138 — B0209 The Uncertainty Classifier:
Use of a Novel Statistical Classifier with
Fuzzy Classification Boundaries to Evaluate
Performance of Automated Electrooculogram
(EOG) testing. Matthew H. Lee 1 , M. Sarossy 2 ,
M. Triglia 3 . 1 Faculty of Medicine, Nursing and
Health Sciences, Monash University, Clayton,
VIC, Australia; 2 Ocular Diagnostic Clinic, Royal
Victorian Eye and Ear Hospital, East Melbourne,
VIC, Australia; 3 Victorian Institute of Forensic
Mental Health, Clifton Hill, VIC, Australia
Thursday Posters
10:30 am – 12:15 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
383

6139 – 6164 – Thursday – Posters
6139 — B0210 Chromatic pseudo-random
VECP: spatial frequency tuning and visual
acuity estimative. Givago S. Souza 1, 2 , I. V.
Martins 1 , B. D. Gomes 1 , L. L. Silveira 1, 2 . 1 Insituto
de Ciencias Biologicas, Universidade Federal do
Para, Belem, Brazil; 2 Nucleo de Medicina Tropical,
Universidade Federal do Para, Belem, Brazil
6140 — B0211 Optimization of Check Size and
Contrast on the Visual-Evoked Potential (VEP)
in Visually-Normal Individuals. Naveen K. Yadav,
K. J. Ciuffreda. Vision Sciences, SUNY, College of
Optometry, New York, NY
6141 — B0212 Macular pigment-based
luminance artifacts do not account for band-pass
temporal tuning of the chromatic visual evoked
potential (cVEP). Rafal M. Skiba, C. S. Duncan, C.
Jones, A. M. Jackson, M. A. Crognale. Psychology,
University of Nevada, Reno, Reno, NV
6142 — B0213 Chromatic and achromatic
contribution to the multifocal visual evoked
potentials. Monique Smyth 4, 3 , C. G. Kilemi 6, 3 ,
G. S. Souza 1, 2 , C. D. Araujo 2 , E. C. Lacerda 2 , M.
M. Jacob 2 , B. D. Gomes 2 , M. E. Fitzgerald 3, 5 ,
L. L. Silveira 1, 2 . 1 Núcleo de Medicina Tropical,
Universidade Federal do Pará, Belém, Brazil;
2
Instituto de Ciências Biológicas, Universidade
Federal do Pará, Belém, Brazil; 3 Christian Brothers
University, Memphis, TN; 4 Rhodes College,
Memphis, TN; 5 University of TN Health Science
Center, Memphis, TN; 6 Coppin State University,
Baltimore, MD
6143 — B0214 Effect of Test Duration on the
Visual-Evoked Potential (VEP) and Alpha Wave
Responses. Kevin T. Willeford, N. K. Yadav, K. J.
Ciuffreda. SUNY State College of Optometry, New
York, NY
6144 — B0215 Effect of Simulated Octant
Visual Field Defects on the Visual-Evoked
Potential (VEP). Diana P. Ludlam, N. K. Yadav,
K. J. Ciuffreda. Vision Sciences, SUNY College of
Optometry, New York, NY
6146 — B0217 Presence of the Gpr179 nob5
mutation in C3H-derived transgenic mice. Jasmin
Balmer 1, 2 , R. Ji 3 , R. G. Gregg 3 , N. S. Peachey 4 ,
V. Enzmann 1 . 1 Department of Ophthalmology,
University of Berne, Berne, Switzerland;
2
Graduate School for Cellular and Biomedical
Sciences, University of Berne, Berne, Switzerland;
3
Department of Biochemistry & Molecular
Biology, University of Louisville, Louisville, KY;
4
Department of Ophthalmic Research, Cleveland
Clinic, Cleveland, OH
6147 — B0218 The luminal and spatiotemporal
dependence of mouse optokinetic contrast
sensitivity on rod pathway components.
Cameron Cowan 1 , M. E. van der Heijden 2 , E. M.
Lo 2 , D. Paul 4 , J. Lem 3 , D. E. Bramblett 5 , S. M.
Wu 2 . 1 Neuroscience, Baylor College of Medicine,
Houston, TX; 2 Ophthalmology, Baylor College of
Medicine, Houston, TX; 3 Ophthalmology, Tufts
Medical Center, Boston, MA; 4 Neurobiology,
Harvard University, Boston, MA; 5 Medical
Education, Texas Tech UHSC, El Paso, TX
6148 — B0219 Intracellular calcium acts
on two separate targets to reduce the gain
mGluR6 signaling in rod bipolar cells. Katherine
Fehlhaber, A. P. Sampath. Neuroscience, University
of Southern California, Los Angeles, CA
6149 — B0220 Metabotropic glycine receptors
can enhance bipolar cell output in rat retina.
Jay Garaycochea, M. Slaughter, J. Myers.
Neuroscience, University at Buffalo, Buffalo, NY
6150 — B0221 Possible roles of glutamate
transporter EAAT5 in mediating mouse
cone on-bipolar cell light responses. Dennis
Y. Tse 1 , I. Chung 1, 2 , S. M. Wu 1 . 1 Ophthalmology,
Baylor College of Medicine, Houston, TX;
2
Ophthalmology, Gyeongsang National University,
Jinju, Republic of Korea
6151 — B0222 Modeling of electroretinography
b-wave amplitudes validates a critical role of
tonic GABA C
receptor-carried chloride currents
in sensitizing and light adapting rod bipolar
cell light responses. Rolf Herrmann 1, 2 , B. Lee 2 ,
E. C. Solessio 3 , V. Y. Arshavsky 2 . 1 Ophthalmology,
Medical College of Wisconsin, Milwaukee, WI;
2
Ophthalmology, Duke University, Durham,
NC; 3 Ophthalmology, SUNY Upstate Medical
University, Syracuse, NY
6152 — B0223 Ca2+ and Ca2+-activated Clcurrents
of Presynaptic Terminals of Bipolar
Cells: A Comparative Study on Mouse and
Goldfish Retinas. Ji Hyun Jeon, S. Paik, I. Kim.
Department of Anatomy, The Catholic University of
Korea, Seoul, Republic of Korea
6153 — B0224 Temporal Filtering in Cone
Bipolar Cells in the Mouse Retina is Partially
Subtype Specific. Tomomi Ichinose 1, 2 , J. A. Cohn 2 .
1
Anatomy & Cell Biology / Ophthalmology, Wayne
State Universtiy School of Medicine, Detroit, MI;
2
Ophthalmology & Visual Sciences, Washington
University School of Medicine, St. Louis, MO
6154 — B0225 Adaptation to background
light permits contrast coding at rod bipolar
cell synapses. Jiangbin Ke 1 , Y. V. Wang 2 , M. S.
Cembrowski 4 , H. Riecke 5 , W. L. Kath 5, 6 , J. B.
Demb 2, 3 , J. H. Singer 1 . 1 Department of Biology,
University of Maryland, College Park, MD;
2
Department of Cellular and Molecular Physiology,
Yale University, New Haven, CT; 3 Department
of Ophthalmology and Visual Science, Yale
University, New Haven, CT; 4 Howard Hughes
Medical Institute, Janelia Farm Research Campus,
Ashburn, VA; 5 Department of Engineering Sciences
and Applied Mathematics, Northwestern University,
Evanston, IL; 6 Department of Neurobiology and
Physiology, Northwestern University, Evanston, IL
6155 — B0226 Quantifying the Effect of Light
Activated Outer and Inner Retinal Inhibitory
Pathways on Exocytosis from Mixed Bipolar
Cells. Mikhail Y. Lipin, J. Vigh. Department of
Biomedical Sciences, Colorado State University,
Fort Collins, CO
6156 — B0227 Cell type-specific Synaptic
Connections of Bipolar and Ganglion Cells in
the Mouse Retina. Sonja Neumann, L. Hüser,
S. Haverkamp. Max Planck Institute for Brain
Research, Frankfurt am Main, Germany
6158 — B0229 CaV3.1 (T-Type) Calcium
Channels in Bipolar Cells of the Macaque
Retina. Theresa Puthussery, J. Gayet, W. R. Taylor.
Ophthal-Casey Eye Inst, Oregon Health & Science
Univ, Portland, OR
6159 — B0230 CACNA1S expression,
structure and function in retinal depolarizing
bipolar cells. Thomas A. Ray 1 , N. Hasan 1 , M. A.
McCall 2 , R. G. Gregg 1 . 1 Biochemistry & Molecular
Biology, University of Louisville, Louisville, KY;
2
Ophthalmology and Visual Sciences, University of
Louisville, Louisville, KY
6160 — B0231 Contribution of RGS proteins
to the light responses of ON-bipolar neurons.
Ignacio Sarria, K. A. Martemyanov. Neuroscience,
The Scripps Research Institute, Jupiter, FL
6161 — B0232 The role of ionotropic glutamate
receptors in dopamine-induced, GABA-driven
rod bipolar cell sensitization. Amanda M. Travis 1 ,
S. J. Heflin 2 , R. Herrmann 2 , V. Y. Arshavsky 2, 1 .
1
Pharmacology, Duke University, Durham, NC;
2
Ophthalmology, Duke University, Durham, NC
Thursday Posters
10:30 am – 12:15 pm
Exhibit Hall B0216-B0235
Thursday, May 09, 2013 10:30 AM-12:15 PM
Visual Neuroscience
540 Bipolar and Horizontal Cells
Moderator: Bart G. Borghuis
6145 — B0216 Tetraphasic Horizontal Cell
in the Retina of Goldfish. Kenkichi Fukurotani.
Faculty of Engineering, University of Toyama,
Toyama, Japan
6157 — B0228 Two Distinct Patterns of Input
Exist Among ON Cone Bipolar Cells and Predict
Their Spatial Responding. Robert Purgert, P. D.
Lukasiewicz. Washington University in St. Louis
School of Medicine, St. Louis, MO
6162 — B0233 The Effect of PKCα on the
Electroretinogram. Wei-Hong Xiong, M. Tekmen-
Clark, S. Lolich, R. M. Duvoisin, C. W. Morgans.
Physiology & Pharmacology, Oregon Health &
Science University, Portland, OR
6163 — B0234 Steady-state Ca modulates
rod bipolar cell exocytosis. Qun-Fang Wan, H.
Ruth. Department of Neurobiology and Anatomy,
University of Texas Medical School at Houston,
Houston, TX
6164 — B0235 Abnormalities of retinal
synaptic ribbons induced by L-AP4. Jun Zhang,
N. Oesch, J. Diamond. Synaptic Physiology
Section, NINDS/NIH, Bethesda, MD
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
384

Thursday – Posters – 6165 – 6179
Exhibit Hall C0050-C0100
Thursday, May 09, 2013 10:30 AM-12:15 PM
Genetics / Visual Neuroscience
541 Genetic Risk Factors for Common
Eye Disorders with Complex Inheritance
Moderators: Stephanie A. Hagstrom and
Margaret A. Pericak-Vance
6165 — C0050 Is AMD a Disease or a
Disorder? A Systems Biology Attempt to Subtype
AMD on the Basis of Gene Expression. Mones
S. Abu-Asab 1 , C. Chan 2, 1 . 1 Histopathology Core,
National Eye Institute, Bethesda, MD; 2 Laboratory
of Immunology, National Eye Institute, Bethesda,
MD
6166 — C0051 Population Attributable Risk
of Known AMD Genetic Risk Factors Based on
the 1000 Genomes Project. Joe M. Butler 1 , Y. C.
Yang 2 , L. I. Paraoan 1 . 1 Eye and Vision Science,
Institute of Ageing and Chronic Disease, University
of Liverpool, Liverpool, United Kingdom;
2
Ophthalmology, Wolverhamptom Med Inst-New
Cross, Wolverhamptom, United Kingdom *CR
6167 — C0052 Association of PTX3
polymorphisms with age-related macular
degeneration and polypoidal choroidal
vasculopathy. Jianhuan Chen 1, 2 , H. Chen 1 , W.
Chen 1 , M. Zhang 1 , C. Pang 1, 2 . 1 Joint Shantou
International Eye Center, Shantou University & the
Chinese University of Hong Kong, Shantou, China;
2
The Chinese University of Hong Kong, Hong
Kong, China
6168 — C0053 Genetic determinants of
Age-related Macular Degeneration in Diverse
Populations: the Population Architecture using
Genomics and Epidemiology (PAGE) Study.
Nicole Restrepo 1 , T. Garrett 2 , P. Buzkova 3 , R. A.
Jensen 3 , B. E. Klein 4 , R. Klein 4 , T. Wong 5 , E. Tai 6 , D.
Crawford 1 . 1 Center for Human Genetics Research,
Vanderbilt University, Nashville, TN; 2 Department
of Epidemiology, University of North Carolina,
Chapel Hill, Chapel Hill, NC; 3 Department of
Biostatistics, University of Washington, Seattle,
WA; 4 Office of Population Genomics, National
Human Genome Research Institute, Bethesda,
MD; 5 Department of Ophthalmology and Visual
Sciences, University of Wisconsin, Madison, WI;
6
Singapore Eye Research Institute, Singapore
national Eye Centre, Singapore, Singapore *CR
6169 — C0054 Association between
δ-sarcoglycan gene (SGCD) polymorphisims
and age-related macular degeneration (AMD)
in Mexican patients. Javier F. Estrada 1 , A. B.
Luna-Angulo 1 , L. G. Cortes-Ballinas 1 , R. Coral-
Vázquez 2 , A. Rendon 4 , D. C. Guadarrama 5 , H.
Rangel-Villalobos 3 , J. C. Zenteno 5 . 1 Biochemistry
and Molecular Biology, Universidad Panamericana,
México, Mexico; 2 seccion de estudios de posgrado
e investigacion.Escuela de Medicina IPN, IPN,
Mexico, Mexico; 3 genetica, Unioversidad de
Guadalajara, Guadalajara, Mexico; 4 Centre de
Recherche, Institut de la Vision, Paris, France;
5
Genética, Instituto de oftalmología Conde de
Valenciana, Mexico, Mexico
6170 — C0055 Association of Family History
with Genetic Risk Factors in Patients with
Age-Related Macular Degeneration. Nicole T.
Saksens 1 , Y. T. Lechanteur 1 , S. K. Verbakel 1 , J. M.
Groenewoud 2 , C. J. Boon 1, 3 , A. I. Den Hollander 1, 4 ,
C. B. Hoyng 1 . 1 Ophthalmology, Radboud University
Nijmegen Medical Center, Nijmegen, Netherlands;
2
Epidemiology, Biostatistics and Health Technology
Assessment, Radboud University Nijmegen
Medical Center, Nijmegen, Netherlands; 3 Oxford
Eye Hospital, John Radcliffe Hospital, University
of Oxford, Oxford, United Kingdom; 4 Human
Genetics, Radboud University Nijmegen Medical
Center, Nijmegen, Netherlands
6171 — C0056 Interaction analysis of
exogenous estrogen in age-related macular
degeneration (AMD) finds novel associations
within the VEGF, Complement, and TGFB
pathways. Monique D. Courtenay 1 , W. Cade 1 ,
S. G. Schwartz 2 , J. L. Kovach 2 , A. Agarwal 3 , G.
Wang 1 , J. L. Haines 4 , M. A. Pericak-Vance 1 , W. K.
Scott 1 . 1 Hussman Institute of Human Genomics,
University of Miami, Miami, FL; 2 Bascom Palmer
Eye Institute, University of Miami, Miami, FL;
3
Ophthalmology, Vanderbilt University, Nashville,
TN; 4 Center for Human Genetics Research,
Vanderbilt University, Nashville, TN *CR
6172 — C0057 Genetic interaction mapping
of AMD identifies potential gene-disease
associations. Lee Kiang, J. Huang, R. E. Tsuchida,
K. T. Jayasundera. Kellogg Eye Center, University
of Michigan, Ann Arbor, MI
6173 — C0058 Cfh genotype interacts with
dietary glycemic index to modulate early agerelated
macular degeneration-like features in
mice. Sheldon Rowan 1 , K. Weikel 1 , M. Chang 1 ,
B. Nagel 2 , J. Thinschmidt 3 , M. B. Grant 3 , S. J.
Fliesler 4, 5 , D. Smith 1 , A. Taylor 1 . 1 Human Nutrition
Research Center on Aging, Tufts University,
Boston, MA; 2 Department of Pathology, Saint
Louis University, Saint Louis, MO; 3 Department
of Pharmacology and Therapeutics, University
of Florida, Gainesville, FL; 4 Research Service,
VAWNYHS, Buffalo, NY; 5 Departments of
Ophthalmology & Biochemistry, SUNY-Buffalo &
SUNY Eye Institute, Buffalo, NY
6174 — C0059 Overexpression of HtrA1 and
Smoking Evokes Choroidal Neovascularization
and Retinal Deposit in Aged Mice. Mao
Nakayama, D. Iejima, M. Akahori, T. Iwata.
National Institute of Sensory organs, Nat’l Hosp
Org Tokyo Med Ctr, Tokyo, Japan
6175 — C0060 Contribution of CFH Y402H
polymorphism and CFHR3/CFHR1 deletion
to age-related macular degeneration in Brazil.
Monica B. Melo 1 , D. D. Sacconi 1 , G. Ananina 1 ,
F. E. Hirata 2 , P. H. Rim 2 , A. M. Torigoe 2 , M. J.
Silva 1 , J. C. Vasconcellos 2 . 1 CBMEG, University
of Campinas, Campinas, Brazil; 2 Ophthalmology,
University of Campinas, Campinas, Brazil
6176 — C0061 Novel CFH variants in
patients with age-related macular degeneration.
Maheswara R. Duvvari 1 , J. P. van de Ven 1 , E.
B. Volokhina 2 , N. T. Saksens 1 , C. J. Boon 1 , L. H.
Hoefsloot 3 , L. van den Heuvel 2 , C. B. Hoyng 1 , A.
I. Den Hollander 1, 3 . 1 Ophthalmology, Radboud
University Nijmegen Medical Centre, Nijmegen,
Netherlands; 2 Pediatrics, Radboud University
Nijmegen Medical Centre, Nijmegen, Netherlands;
3
Human Genetics, Radboud University Nijmegen
Medical Centre, Nijmegen, Netherlands
6177 — C0062 Targeted Sequencing,
Augmented with Public Resources, Identifies
a Rare C3 Allele Associated with Large Risk
of Age-related Macular Degeneration. Xiaowei
Zhan 1, 2 , D. E. Larson 3, 4 , R. S. Fulton 3, 4 , C. Wang 5 ,
D. Stambolian 6 , E. Y. Chew 7 , E. Mardis 3, 4 , A.
Swaroop 7 , G. Abecasis 1, 2 . 1 Biostatistics, University
of Michigan, Ann Arbor, MI; 2 Center of Statistical
Genetics, University of Michigan, Ann Arbor, MI;
3
The Genome Institute, Washington University, St.
Louis, MO; 4 Department of Genetics, Washington
University, St. Louis, MO; 5 Department of
Biostatistics, Harvard University, Boston, MA;
6
Department of Ophthalmology and Human
Genetics, University of Pennsylvania, Philadelphia,
PA; 7 National Eye Institute, Bethesda, MD *CR
6178 — C0063 Three New Genetic Loci
(R1210C mutation in CFH, SNPs in COL8A1
and RAD51B) are Related to Progression to
Advanced Stages of Age-Related Macular
Degeneration. Johanna M. Seddon 1, 2 , R.
Reynolds 1 , Y. Yu 1 , S. Raychaudhuri 3, 4 , B. Rosner 5 .
1
Ophthalmic Epidemiology and Genetics Service,
New England Eye Center, Tufts Medical Center,
Boston, MA; 2 Ophthalmology, Tufts University
School of Medicine, Boston, MA; 3 Divisions of
Rheumatology and Genetics, Brigham and Women’s
Hospital, Harvard Medical School, Boston, MA;
4
Program in Medical and Population Genetics,
Broad Institute of Harvard and MIT, Boston, MA;
5
Channing Laboratory, Boston, MA *CR
6179 — C0064 Investigating Age-related
Macular Degeneration in the Amish. Joshua
D. Hoffman 1 , L. D’Aoust 1 , L. Jiang 1 , R. Laux 1 ,
A. Agarwal 3 , W. K. Scott 2 , M. A. Pericak-Vance 2 ,
J. L. Haines 1 . 1 Ctr for Human Genetics Resrch,
Vanderbilt Univ Medical Center, Nashville,
TN; 2 Hussman Institute for Human Genomics,
University of Miami, Miami, FL; 3 Ophthalmology,
Vanderbilt Univ Medical Center, Nashville, TN *CR
Thursday Posters
10:30 am – 12:15 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
385

6180 – 6196 – Thursday – Posters
Thursday Posters
10:30 am – 12:15 pm
6180 — C0065 Genetic Risk Score Predicts of
Severity of Age-related Macular Degeneration.
Jonathan L. Haines 1 , A. Agarwal 1 , J. N. Cooke
Bailey 1 , J. D. Hoffman 1 , J. McGrath 1 , L. M. Olson 1 ,
J. L. Kovach 2 , S. G. Schwartz 2 , W. K. Scott 3 , M. A.
Pericak-Vance 3 . 1 Ctr Human Genetics Res-Med
Ctr, Vanderbilt University, Nashville, TN; 2 Bascom
Palmer Eye Institute, Naples, FL; 3 Human Genetics,
University of Miami, Miami, FL *CR
6181 — C0066 The association of elastin
gene variants with two angiographic subtypes
of polypoidal choroidal vasculopathy. Shigeru
Honda, S. Yanagisawa, A. Miki, W. Matsumiya,
A. Negi. Kobe University Graduate School of
Medicine, Kobe, Japan
6182 — C0067 Associations of C3 with
neovascular age-related macular degeneration
and polypoidal choroidal vasculopathy. Ke
Liu, L. Chen, P. Tam, C. Pang. Department of
Ophthalmology and Visual Sciences, The Chinese
University of Hong Kong, Hong Kong, China
6183 — C0068 Polymorphisms association
of CFH, BF, C3, FHR 1-3 and ARMS2 genes
with geographic atrophy progression in Age-
Related Macular Degeneration. Sergio Recalde,
P. Fernandez, L. Garcia-Garcia, J. M. Caire, A.
I. Hernández, V. Fernandez-Garcia, M. Moreno-
Orduña, A. Garcia-Layana. Ophthalmology,
Universidad de Navarra, Pamplona, Spain
6184 — C0069 Genotype Analysis for Single
Nucleotide Polymorphisms Profile of Eyes with
Vascularized Pigment Epithelial Detachment
due to AMD. Clement K. Chan 1, 2 , D. Sarraf 3 , P.
Abraham 4 , D. H. Nguyen 5 , S. G. Lin 1 , M. Lalezary 1 ,
K. Zhang 5, 6 . 1 Vitreoretina, Southern California
Desert Retina Consultants, Palm Desert, CA;
2
Department of Ophthalmology, Loma Linda
University, Loma Linda, CA; 3 Retinal Disorders
and Ophthalmic Genetics Division, Jules Stein Eye
Institute, University of California, Los Angeles, Los
Angeles, CA; 4 Retina Section, Black Hills Regional
Eye Institute, Rapid City, SD; 5 Department of
Ophthalmology, University of California, San
Diego, San Diego, CA; 6 Institute of Genomic
Medicine, Shiley Eye Center, University of
California, San Diego, San Diego, CA *CR, f
6185 — C0070 Pharmacogenetic associations in
neovascular age-related macular degeneration.
Results from the IVAN study. Andrew J. Lotery 1, 2 ,
J. Gibson 3 , A. J. Cree 1 , S. M. Downes 4 , S. P.
Harding 5 , C. Rogers 6 , B. C. Reeves 6 , S. Ennis 3 , U.
Chakravarthy 7 . 1 Clinical & Experimental Sciences,
Faculty of Medicine, University of Southampton,
Southampton, United Kingdom; 2 Southampton
Eye Unit, University Hospital Southampton
NHS Foundation Trust, Southampton, United
Kingdom; 3 Human Development and Health,
Faculty of Medicine, University of Southampton,
Southampton, United Kingdom; 4 Oxford Eye
Hospital, Oxford University Hospitals NHS Trust,
Oxford, United Kingdom; 5 Department of Eye and
Vision Science, University of Liverpool, Liverpool,
United Kingdom; 6 School of Clinical Sciences,
University of Bristol, Bristol, United Kingdom;
7
The Institute for Ophthalmology and Vision
Science, The Queen’s University of Belfast, Belfast,
United Kingdom *CR, f
6186 — C0071 The Role of Genetics in
Response to Anti-VEGF Therapy for Wet AMD.
Jaclyn L. Kovach 1 , A. Agarwal 2 , S. G. Schwartz 1 , M.
A. Brantley 2 , W. Cade 3 , J. L. Haines 4 , M. A. Pericak-
Vance 3 . 1 Ophthalmology, Bascom Palmer Eye
Institute, Naples, FL; 2 Ophthalmology, Vanderbilt
Eye Insitute, Nashville, TN; 3 Institute for Human
Genomics, University of Miami Miller School of
Medicine, Miami, FL; 4 Human Genetics, Vanderbilt
University School of Medicine, Nashville, TN *CR
6187 — C0072 VEGF-A and VEGFR-2 Gene
Polymorphisms and Response to Anti-VEGF
Therapy in the Comparison of AMD Treatments
Trials (CATT). Stephanie A. Hagstrom 1, 2 , G.
Ying 3 , G. J. Pauer 1 , G. M. Sturgill-Short 1 , J.
Huang 3 , M. G. Maguire 3 , D. F. Martin 1 . 1 Cole
Eye Institute, Cleveland Clinic, Cleveland, OH;
2
Ophthalmology, Cleveland Clinic Lerner College
of Case Western Reserve University, Cleveland,
OH; 3 Ophthalmology, University of Pennsylvania,
Philadelphia, PA *CR, f
6188 — C0073 Enhancer elements show
enrichment for AMD-associated genetic variants.
Lakshmi P. Pulagam 1 , N. J. Morris 1 , P. Benchek 1 ,
P. Scacheri 2 , S. K. Iyengar 1, 2 . 1 Epidemiology and
Biostatistics, Case Western Reserve University,
Cleveland, OH; 2 Genetics and Genome Sciences,
Case Western Reserve University, Cleveland, OH
6189 — C0074 Early Biomarkers of AMD
(EBAMD) Study - Design and Baseline Data:
IRB-11-5677. Steven G. Pratt 1 , S. P. Richer 2 , C.
Perry 1, 3 , G. Ruteledge 4 , C. Podella 2 . 1 Scripps
Health/Scripps Memorial Hospital/Scripps Mericos
Eye Institute/Scripps Clinical Research Service, La
Jolla, CA; 2 Eye Clinic, Capt James A Lovell FHCC,
North Chicago, IL; 3 Ophthalmology, University
of Iowa, Iowa City, IA; 4 Biology, University of
California, Irvine, CA f
6190 — C0075 Association of the SOD activity,
rs1061170 in CFH and rs1531289 in VEGFR2
with protein levels in North Indian age related
macular degeneration patients. Neel Sharma 1 ,
A. Gupta 2 , S. Prabhakar 1 , R. Singh 2 , S. Sharma 3 ,
A. Anand 1 . 1 Neurology, Post Graduate Institute
of Medical Education and Research, Chandigarh,
India; 2 Ophthalmology, Post Graduate Institute
of Medical Education and Research, Chandigarh,
India; 3 Statistics, Panjab University, Chandigarh,
India
6191 — C0076 AMD-associated variants
at chromosome 10q26 locus and ARMS2/
HTRA1gene expression. Gaofeng Wang 1 , B.
Court 1 , P. Gay 1 , S. R. Dubovy 2 , J. L. Kovach 2 ,
S. G. Schwartz 2 , A. Agarwal 3 , W. K. Scott 1 , J. L.
Haines 4 , M. A. Pericak-Vance 1 . 1 Hussman Inst for
Human Genomics, Univ of Miami Miller Sch of
Med, Miami, FL; 2 Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL; 3 Ophthalmology, Vanderbilt University,
Nashville, TN; 4 Center for Human Genetics
Research, Vanderbilt University, Nashville, TN *CR
6192 — C0077 Differential gene expression of
RPE and choroid in old Cfh transgenic mice.
Cynthia X. Wang, B. Aredo, X. Chen, R. Ufret-
Vincenty. Ophthalmology, UTSW Medical Center,
Dallas, TX
6193 — C0078 GSTM1 and GSTM5
Polymorphisms and Expression in AMD. Allan
A. Hunter, Z. Smit-McBride, R. Anderson, E.
Kim, S. S. Park, L. M. Hjelmeland, L. S. Morse.
Ophthalmology, University of California, Davis,
Sacramento, CA *CR
6194 — C0079 Mitochondrial DNA
Heteroplasmy in Retinas of AMD Patients. Hui
Cai 1 , P. L. Nagy 2 , R. Allikmets 1, 2 . 1 Ophthalmology,
Columbia University Medical Center, New
York, NY; 2 Pathology & Cell Biology, Columbia
University Medical Center, New York, NY
6195 — C0080 Comparison Between
Haplogroup H and L Cybrids in ROS/RNS
Production and Gene Expression Further
step in understanding the pathogenesis of
Age-related Macular Degeneration. Mohamed
Tarek 1 , J. Cáceres del Carpio 1 , C. A. Ramirez 1 ,
P. Falatoonzadeh 1 , S. Atilano 1 , D. Malik 1 , S.
Jazwinski 2 , M. V. Michael 2 , B. D. Kuppermann 1 , C.
M. Kenney 1 . 1 Gavin Herbert Eye Institute, Irvine,
CA; 2 Tulane Center For Aging, Tulane University,
New Orleans, LA *CR
6196 — C0081 Genetic Testing for Age-
Related Macular Degeneration in an Armenian
Population. Abraham Abraamyan 1 , B. Zanke 3 , P.
Ramamoorthy 2 , K. W. Small 1 . 1 Macula & Retina
Institute, Glendale, CA; 2 Advanced Diagnostics
Laboratory, Denver, CO; 3 Arctic Dx - Macula Risk,
Bonita Springs, FL *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
386

Thursday – Posters – 6197 – 6214
6197 — C0082 Global Review and Metaanalysis
of Diabetic Retinopathy Genetic Studies
Highlight Gaps in the Pathogenesis between
Various Populations. Shi Song Rong, P. Tam, C.
Pang, L. Chen. Dept. Ophthalmology & Visual
Sciences, The Chinese University of Hong Kong,
Hong Kong, China
6198 — C0083 Relating risk genotypes
for diabetic retinopathy with color vision
performance. Mirella Gualtieri 1 , D. M. Bonci 2 ,
V. D. Duarte Garcia 2 , S. Juel 3 , F. Damico 5 , M.
Neitz 4 , D. F. Ventura 1, 2 . 1 Experimental Psychology,
University of Sao Paulo, Sao Paulo, Brazil;
2
Neuroscience & Behavio, University of Sao
Paulo, Sao Paulo, Brazil; 3 Minority Health and
Health Disparities International Research Training
Program, Menphis, TN; 4 Ophthalmology, University
of Washington, Seattle, WA; 5 Ophthalmology,
University of Sao Paulo, Sao Paulo, Brazil *CR
6199 — C0084 MicroRNA-126 Regulates Heme
Oxygenase-1-Mediated Alterations in Diabetic
Retinopathy. Jiawen Fan, G. Xu, T. Jiang, Y. Qin,
X. Wang. Ophthalmology Department, Eye and ENT
Hospital of Fudan Univ, Shanghai, China
6200 — C0085 Identification of Risk Alleles
in the Erythropoietin gene for Proliferative
Diabetic Retinopathy in Type I and Type II
Diabetics. Stephen Juel 3 , D. M. Bonci 1, 2 , M.
Gualtieri 1, 2 , V. D. Duarte Garcia 1, 2 , M. Neitz 4 , D. F.
Ventura 1, 2 . 1 Psicologia Experimental, Universidade
de São Paulo, São Paulo, Brazil; 2 Núcleo de
Neurociências e Comportamento, Universidade
de São Paulo, São Paulo, Brazil; 3 Minority
Health International Research Training Program,
Christian Brothers University, Memphis, TN;
4
Ophthalmology, University of Washington, Seattle,
WA *CR
6201 — C0086 Expression Of VEGF-A Gene
In Normal Retina And In PVR Retina. Claudio
Azzolini 1 , I. S. Pagani 2 , D. Borroni 1, 2 , C. Pirrone 2 ,
D. Pigni 2 , M. Al Oum 1 , R. Vinciguerra 1 , S. Donati 1 ,
G. Porta 2 . 1 Morphological and Surgical Sciences,
University of Insubria - Circolo Hospital, Varese,
Italy; 2 Department of Clinical and Experimental
Medicine, University of Insubria, Varese, Italy
6202 — C0087 Thrombophilic mutations and
risk of retinal vein occlusion. Silvia R. Mendes,
A. F. Campos, D. Beselga, A. Neves, J. Campos,
D. Castanheira. Ophthalmology, Leiria, Leiria,
Portugal
6203 — C0088 Association study of IL23R-
IL12RB2 and IL10 gene polymorphisms with
susceptibility to Vogt-Koyanagi-Harada disease
in a Japanese population. Akira Meguro 1 , T.
Kawagoe 1 , M. Nakahara 1, 2 , H. Fukasaku 1, 2 , S.
Ohno 3 , N. Mizuki 1 . 1 Department of Ophthalmology,
Yokohama City Univ School of Med, Yokohama,
Japan; 2 Fukasaku Eye Clinic, Yokohama, Japan;
3
Ocular Inflammation and Immunology, Hokkaido
University Graduate School of Medicine, Sapporo,
Japan
6204 — C0089 Genetic Screening of TSPAN12,
NDP and FZD4 Genes in Indian Patients with
Retinopathy of Prematurity. Inderjeet Kaur 1 , S.
Rathi 1 , G. R. Musada 1 , S. Jalali 2 , R. Kekunnaya 3 ,
P. Gaddam 4 , S. Chakrabarti 1 . 1 Kallam Anji Reddy
Molecular Genetics Lab, LV Prasad Eye Institute,
Hyderabad, India; 2 Smt.Kannuri Santhamma Centre
for Vitreo Retinal Diseases, LV Prasad Eye Institute,
Hyderabad, India; 3 Jasti V Ramanamma Children’s
Eye Care Centre, LV Prasad Eye Institute,
Hyderabad, India; 4 Fernandez Hospital, Hyderabad,
India
6205 — C0090 Transcriptional regulation
of synaptotagmin 11 in retinal ganglion cells.
Gillian C. Shaw 1, 2 , C. A. Berlinicke 1 , D. J. Zack 1 .
1
Ophthalmology, Johns Hopkins University,
Baltimore, MD; 2 Molecular and Comparative
Pathobiology, Johns Hopkins University, Baltimore,
MD *CR
6206 — C0091 Systems Genetics of Intraocular
Pressure—Mice to Humans: The Use of
BXD Murine Reference Panel for Identifying
Novel Genetic Modulators of Glaucoma
and Bidirectional Translation. Monica M.
Jablonski 1, 2 , S. Swaminathan 1 , H. Lu 1 , J. L. Wiggs 3 ,
R. W. Williams 2 , L. Lu 2 . 1 Hamilton Eye Institute,
Univ Tennessee Health Sci Ctr, Memphis, TN;
2
Anatomy & Neurobiology, The University of
Tennessee Health Science Center, Memphis, TN;
3
Ophthalmology, Harvard Medical School MEEI,
Boston, MA *CR
6207 — C0092 Genetic variation of superoxide
dismutases in patients with primary open-angle
glaucoma. Dragana Celojevic 1 , S. Nilsson 2 , A.
Petersen 1 , G. Tasa 3 , E. Juronen 3 , M. Zetterberg 1 .
1
Institute of Neuroscience & Physiology, University
of Gothenburg, Gothenburg, Sweden; 2 Institute
of Mathematical Sciences, Chalmers University
of Technology, Gothenburg, Sweden; 3 Institute of
General and Molecular Pathology, University of
Tartu, Tartu, Estonia
6208 — C0093 COCH Variants are not
Associated with Primary-open Angle Glaucoma
or Intraocular Pressure in Caucasians.
Danyi Wang 1 , B. Fan 1 , Y. Liu 2 , M. A. Hauser 2 ,
R. Allingham 3 , J. L. Haines 4 , J. L. Wiggs 1 .
1
Ophthalmology, Harvard Med Sch, Massachusetts
Eye & Ear Infirmary, Boston, MA; 2 Ophthalmology
& Medicine, Duke University Medical Center,
Durham, NC; 3 Ophthalmology, Duke University
Medical Center, Durham, NC; 4 Center for Human
Genetics Research, Vanderbilt University School of
Medicine, Nashville, TN *CR
6209 — C0094 Family-based Genomewide
Association Study in South Indian
Consanguineous Pedigrees confirms association
between ZNF469 and central corneal thickness.
Baojian Fan 1 , N. Soumittra 2 , S. Sripriya 2 , D. S.
Friedman 3 , V. Lingam 4 , J. L. Haines 5 , R. J. George 4 ,
J. L. Wiggs 1 . 1 Dept of Ophthalmology, Harvard
Med Sch Massachusetts Eye & Ear Infirmary,
Boston, MA; 2 Vision Research Foundation, Sankara
Nethralaya, Chennai, India; 3 Ophthalmology, Johns
Hopkins Medical School Wilmer Eye Institute,
Baltimore, MD; 4 Medical Research Foundation,
Sankara Nethralaya, Chennai, India; 5 Center for
Human Genetic Research, Vanderbilt University
School of Medicine, Nashville, TN *CR
6210 — C0095 Fine mapping of the RXRA-
COL5A1 locus for central corneal thickness.
Xiaoyi Gao 1 , Y. Liu 2 , W. Gauderman 3 , M. Torres 1 , T.
Haritunians 4 , J. Z. Kuo 4 , K. Taylor 4 , J. I. Rotter 4 , R.
Varma 1 . 1 Department of Ophthalmology and Visual
Sciences, University of Illinois at Chicago, Chicago,
IL; 2 Department of Medicine, Duke University,
Durham, NC; 3 Department of Preventive Medicine,
University of Southern California, Los Angeles,
CA; 4 Medical Genetics Institute, Cedars-Sinai
Medical Center, Los Angeles, CA *CR
6211 — C0096 Validation of APLP2 as
Potential Candidate Gene for Human Myopia
Linked to Chromosome 11q24.3. Andrei V.
Tkatchenko 1, 2 , P. Singh 2 , A. Kumar 2, 1 , T. V.
Tkatchenko 1 . 1 Anatomy & Cell Biology, Wayne
State University, Detroit, MI; 2 Ophthalmology,
Wayne State University, Detroit, MI
6212 — C0097 UV-Independent p53 Mutations
in Sebaceous Carcinoma of the Eyelid. Rehan M.
Hussain 1 , J. L. Matthews 1 , S. R. Dubovy 1 , G. Wang 2 .
1
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 2 Human Genetics, John P. Hussman
Institute for Human Genomics, Miami, FL
6213 — C0098 Genome-wide Analysis of
Ocular Adnexal Lymphoproliferative Disorders
Using High Resolution Single Nucleotide
Polymorphism Array. Hiroki Takahashi 1 , Y. Usui 1 ,
R. Mitsuhashi 1 , N. Yamakawa 1 , A. Sato-Otsubo 2 , Y.
Sato 2 , S. Ogawa 2 , A. Arai 3 , H. Goto 1 . 1 Department of
Ophthalmology, Tokyo Medical University, Tokyo,
Japan; 2 Cancer Genomics Project, The University of
Tokyo, Tokyo, Japan; 3 Department of Hematology,
Tokyo Medical and Dental University, Tokyo, Japan
6214 — C0099 Rb1 knockdown selectively
induces cone precursor proliferation and
tumor formation dependent on cone-specific
signaling. Xiaoliang L. Xu 1 , P. K. Bradford 4 , H.
P. Singh 2 , D. H. Abramson 3 , S. C. Jhanwar 1 , D.
Cobrinik 2 . 1 Department of Pathology, Memorial
Sloan Kettering Cancer Center, New York, NY;
2
Department of Pediatrics, Memorial Sloan
Kettering Cancer Center, New York, NY; 3 Ocular
Oncology Service, Memorial Sloan Kettering
Cancer Center, New York, NY; 4 Albert Einstein
College of Medicine, New York, NY *CR
Thursday Posters
10:30 am – 12:15 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
387

6215 – 6232 – Thursday – Posters
Thursday Posters
10:30 am – 12:15 pm
6215 — C0100 Downregulation of MITF Leads
to Uveal Melanoma Cell Apoptosis and Cell
Cycle G1 Arrest. Lihua Wang, X. Chen, J. Wang,
D. Yan. 1 School of Ophthalmology and Optometry,
Wenzhou Medical College, Wenzhou, China
Exhibit Hall C0101-C0134
Thursday, May 09, 2013 10:30 AM-12:15 PM
Glaucoma
542 Genetics II
Moderators: Janey L. Wiggs and David A. Mackey
6216 — C0101 The association of single
nucleotide polymorphisms in the connective
tissue growth factor gene with pseudoexfoliation
syndrome/glaucoma. Wool Suh 1 , C. Kee 2 .
1
Ophthalmology, Hallym University Sacred Heart
Hosp, Anyang, Kyeonggi-do, Republic of Korea;
2
Ophthalmology, Samsung Medical Center,
Sungkyunkwan University School of Medicine,
Seoul, Republic of Korea
6217 — C0102 CYP1B1 mutations, a major
contributor to juvenile-onset open angle
glaucoma. Khaled K. Abu-Amero 1, 3 , J. Morales 2 ,
L. Ali Aljasim 2 , D. P. Edward 2 . 1 Ophthalmology,
College of Med, King Saud Univ, Riyadh, Saudi
Arabia; 2 King Khalied Eye Specilaist Hospital,
Riyadh, Saudi Arabia; 3 Ophthalmology, College of
Medicine, Jacksonville, FL
6218 — C0103 Last results of the Spanish
Multicenter Genetic Glaucoma Group. Elena
Milla 1, 5 , S. Duch 2 , M. Carballo 3 , M. Gamundi 4 .
1
Institut Comtal d’Oftalmologia and Hospital Clinic,
Barcelona, Spain; 2 Glaucoma, Institut Comtal
d’Oftalmologia, Barcelona, Spain; 3 Hospital de
Terrassa, Barcelona, Spain; 4 Hospital de Terrassa,
Barcelona, Spain; 5 Spanish Multicenter Genetic
Glaucoma Group, 18 Spanish Eye Centers, Spain,
Spain
6219 — C0104 Identification of S1 RNA
Binding Domain-1 SRBD1 as a Major Gene
Determining Glaucoma in Dogs. Nobuyuki
Kanemaki 1 , K. T. Tchedre 2 , M. Imayasu 2 , A.
Meguro 3 , N. Mizuki 3 . 1 Veterinary Teaching Hospital,
Azabu University, Sagamihara, Japan; 2 Central
R&D Laboratory, Menicon Co., Ltd., Kasugai,
Japan; 3 Department of Ophthalmology, Yokohama
City University School of Medicine, Yokohama,
Japan *CR
6220 — C0105 MYOC Variants In POAG
In Black South Africans. Susan E. Williams 1 ,
T. Wainstein 2 , T. R. Carmichael 1 , M. Ramsay 2 .
1
Ophthalmology, University of the Witwatersrand,
Johannesburg, South Africa; 2 Human Genetics,
University of the Witwatersrand, Johannesburg,
South Africa
6221 — C0106 Genetic Susceptibility
Variations and Visual Field Progression in
Chinese Patients with Primary Angle Closure
Glaucoma. Xin Wei 1, 2 , C. Khor 3, 4 , J. S. de
Leon 2 , E. N. Vithana 2, 4 , M. E. Nongpiur 2, 4 , S.
Perera 2 , T. Aung 2, 4 . 1 Duke-National University of
Singapore Graduate Medical School, Singapore,
Singapore; 2 Singapore Eye Research Institute,
Singapore National Eye Center, Singapore,
Singapore; 3 Human Genetics, Genome Institute of
Singapore, Singapore, Singapore; 4 Department of
Ophthalmology, National University Health System
& National University of Singapore, Singapore,
Singapore *CR
6222 — C0107 The Association Between
Ocular Biometric Parameters and the Three
Novel Primary Angle Closure Glaucoma (PACG)
Susceptibility Loci. Monisha E. Nongpiur 1, 2 ,
C. Khor 3, 4 , L. Xu 5 , J. B. Jonas 6 , J. Wang 5 , T. Y.
Wong 1, 7 , E. N. Vithana 1 , T. Aung 1, 7 . 1 Glaucoma,
Singapore Eye Research Inst, Singapore, Singapore;
2
DUKE-NUS Graduate Medical School, Singapore,
Singapore; 3 Genome Institute Of Singapore,
Singapore, Singapore; 4 Centre for Molecular
Epidemiology, Singapore, Singapore; 5 Beijing
Institute of Ophthalmology, Beijing, China;
6
Ophthalmology, Medical Faculty Mannheim-
Heidelberg, Mannheim, Germany; 7 Ophthalmology,
Yong Loo Lin School of Medicine, Singapore,
Singapore *CR
6223 — C0108 Protein tyrosine phosphatase
Meg2 deficient mice - A powerful model to
study glaucoma disease? Jacqueline Reinhard 1 ,
S. Wiemann 1 , S. C. Joachim 2 , H. Schmid 2 , B.
Denecke 3 , Y. Wang 4 , G. P. Downey 5, 6 , A. Faissner 1 .
1
Cell Morphology & Molecular Neurobiology,
Ruhr-University Bochum, Bochum, Germany;
2
Experimental Eye Research Institute, Ruhr-
University Bochum, Bochum, Germany;
3
Interdisciplinary Center for Clinical Research,
RWTH Aachen University, Aachen, Germany;
4
Department of Medicine, University of Toronto,
Toronto, ON, Canada; 5 Department of Medicine,
National Jewish Health, Denver, CO; 6 Departments
of Medicine and Integrated Department of
Immunology, University of Colorado, Aurora, CO
6224 — C0109 Association of Glutathione S
Transferases Polymorphisms with Glaucoma: A
Meta-analysis. Yibo Yu, K. Yao. Eye Center, Second
Affiliated Hospital, College of Medicine, Zhejiang
University, Hangzhou, China
6225 — C0110 Predicting Gene Networks and
Transcription Factors in TNFα Treatment of
Trabecular Meshwork Cells. Dongseok Choi 1 ,
L. Hayashi 2 , K. Carr 1 , M. J. Kelley 2 , T. S. Acott 2 .
1
Biostatistics, Public Hlth & Preventive Med,
Oregon Health & Science Univ, Portland, OR;
2
Casey Eye Institute, Oregon Health & Science
Univ, Portland, OR
6226 — C0111 Mouse Genomic Loci
Modulating Ganglion Cell Loss in Glaucoma.
Eldon E. Geisert 1 , S. G. Hart 1 , X. Wang 1 , J. L.
Wiggs 2 . 1 Ophthalmology, Univ of Tennessee Health
Sci Ctr, Memphis, TN; 2 Ophthalmology, Harvard
Medical School, Boston, MA
6227 — C0112 Association between primary
open-angle glaucoma and genetic variants
associated with normal tension glaucoma.
Fumihiko Mabuchi 1 , Y. Sakurada 1 , K. Kashiwagi 1 ,
Z. Yamagata 2 , H. Iijima 1 . 1 Ophthalmology,
University of Yamanashi, Chuo, Japan; 2 Health
Sciences, University of Yamanashi, Chuo, Japan
6228 — C0113 Analysis of Ophthalmic Clinical
Data Association for CDKN2B-AS1 Genotype in
Normal Subjects. Yoko Ikeda 1 , K. Mori 1 , M. Ueno 1 ,
M. Nakano 2 , Y. Tokuda 2 , N. Omi 2 , R. Sato 2 , K.
Yoshii 3 , K. Tashiro 2 , S. Kinoshita 1 . 1 Ophthalmology,
Kyoto Prefectural Univ of Med, Kamigyo-ku,
Japan; 2 Genomic Medical Sciences, Kyoto
Prefectural University of Medicine, Kyoo, Japan;
3
Judo Therapy, Takarazuka University of Medical
and Health Care, Takarazuka, Japan *CR
6229 — C0114 The Role of Protein-Coding
Variants in South Africans with Exfoliation
Glaucoma. Yutao Liu 1, 2 , X. Qin 1 , J. Gibson 1 , S. E.
Williams 3 , R. M. Rautenbach 4 , T. R. Carmichael 3 ,
A. E. Ashley-Koch 1 , R. Allingham 2 , M. A. Hauser 1, 2 .
1
Medicine, Duke University Medical Center,
Durham, NC; 2 Ophthalmology, Duke University
Medical Center, Durham, NC; 3 Neurosciences,
University of the Witwatersrand, Johannesburg,
South Africa; 4 Surgical Sciences, Stellenbosch
University, Stellenbosch, South Africa *CR
6230 — C0115 Mouse Genomic Loci
Modulating Corneal Thickness. XiangDi
Wang 1 , S. G. Hart 1 , J. L. Wiggs 2 , E. E. Geisert 1 .
1
Ophthalmology, University of Tennessee Health
Science Center, Memphis, TN; 2 Ophthalmology-
Harvard Medical School, Mass Eye & Ear
Infirmary, Boston, MA
6231 — C0116 Identification and
Characterization of Genetic Factors Responsible
for Cavitary Optic Disc Anomalies. Ralph
J. Hazlewood 1 , B. Roos 1 , R. A. Honkanen 2 , L.
M. Jampol 3 , W. L. Alward 1 , Y. H. Kwon 1 , E. M.
Stone 1, 4 , J. H. Fingert 1, 5 . 1 Ophthalmology and
Visual Sciences, University of Iowa, Iowa City, IA;
2
Ophthalmology, State University of New York at
Stony Brook, Stony Brook, NY; 3 Ophthalmology,
Feinberg School of Medicine, Northwestern
University, Chicago, IL; 4 Howard Hughes Medical
Institute, Iowa City, IA; 5 Anatomy and Cell
Biology, University of Iowa, Iowa City, IA *CR
6232 — C0117 Association Study of Multiple
Gene Polymorphisms with the Risk of Adult-
Onset Primary Open-Angle Glaucoma in a
Mexican Population. Jesus Cabral 1 , B. Buentello 1 ,
D. C. Guadarrama 1 , J. C. Zenteno 1, 4 , C. Elizondo 2 ,
A. Miranda 3 . 1 Research Unit Genetics, Institute
of Ophtalmology Conde De Valenciana, Mexico
City, Mexico; 2 Glaucoma Department, Institute
of Ophtalmology Conde De Valenciana, Mexico
City, Mexico; 3 Department Of Genetics, National
Institute of Rehabilitation, Mexico City, Mexico;
4
Department of Biochemistry, National Autonomous
University of Mexico, Mexico City, Mexico
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
388

Thursday – Posters – 6233 – 6249
6233 — C0118 A genetic variant in TMCO1 is
strongly associated with primary open angle,
primary angle closure and pseudoexfolation
glaucoma. Shazia Micheal 1, 2 , H. Ayub 2, 1 , M. I.
Khan 2, 3 , B. Bakker 1 , F. E. Schoenmaker-Koller 1 ,
M. Ali 4 , F. Akhtar 4 , R. Qamar 1, 5 , A. I. Den
Hollander 1, 3 . 1 Ophthalmology, UMC St Radboud,
Nijmegen, Netherlands; 2 Biosciences, COMSATS
Institute of Information Technology, Islamabad,
Pakistan; 3 Human Genetics, Radboud University
Nijmegen Medical Centre, Nijmegen, Netherlands;
4
Glaucoma, Al-Shifa Trust Eye Hospital,
Rawalpindi, Pakistan; 5 Shifa College of Medicine,
Shifa Tameer-e-Millat University, Islamabad,
Pakistan
6234 — C0119 The association between CAV1/2
region loci and their relation with primary
open angle glaucoma. Stephanie Loomis 1, 2 , L.
R. Pasquale 1, 2 , J. H. Kang 2 , M. A. Hauser 4, 5 , B.
Yaspan 3 , J. L. Haines 3 , J. L. Wiggs 1 . 1 Department
of Ophthalmology, Massachusetts Eye and Ear
Infirmary, Boston, MA; 2 Department of Medicine,
Channing Division of Network Medicine, Boston,
MA; 3 Center for Human Genetics Research,
Vanderbilt University, Nashville, TN; 4 Department
of Ophthalmology, Duke University, Durham, NC;
5
Department of Medicine, Duke University Medical
Center, Durham, NC *CR
6235 — C0120 Next Generation Sequencing
Identifies Novel Variants of Mitochondrial
DNA in Normal-Tension Glaucoma Patients.
Dong Myung Kim 1 , J. Jeoung 1 , M. Seong 2 , S.
Park 2 . 1 Ophthalmology, Seoul National University
Hospital, Seoul, Republic of Korea; 2 Laboratory
Medicine, Seoul National University Hospital,
Seoul, Republic of Korea
6236 — C0121 Revisit the association of CAV1/
CAV2 with primary open-angle glaucoma. Li Jia
Chen, P. Tam, C. Pang. Ophthalmology & Visual
Sciences, The Chinese University of Hong Kong,
Hong Kong, China
6237 — C0122 Clinical Profile Of A Large
Family With Primary Open Angle Glaucoma
(POAG) In South Indian Population. Mohideen
A. Kader 1 , R. Ramakrishnan 1 , S. Krishnadas 2 ,
P. Namburi 3 , P. Sundaresan 3 , A. L. Robin 4 , P. Y.
Ramulu 5 , J. H. Fingert 6 . 1 Glaucoma, Aravind Eye
Hospital, Tirunelveli, India; 2 Glaucoma, Aravind
Eye Hospital, Madurai, India; 3 Genetics, Aravind
Medical Research Foundation, Madurai, India;
4
John Hopkins University, Baltimore, MD; 5 Wilmer
Eye Institute, Baltimore, MD; 6 Department of
Ophthalmology and Visual Sciences, Carver
College of Medicine, University of Iowa, Iowa City,
IA *CR
6238 — C0123 POAG blood and hyaluronic
acid challenged monocytes upregulate CD44s
and isoforms: A new biomarker? Paulius Kuprys 1 ,
A. Grybauskas 1 , K. Skuran 1 , P. A. Knepper 1, 2 .
1
Ophthalmology and Visual Sciences, Univerisity of
Illinois at Chicago, Chicago, IL; 2 Ophthalmology,
Northwestern University Medical School, Chicago,
IL
6239 — C0124 Rare Genetic Variants in
African Americans with Primary Open Angle
Glaucoma. Allison E. Ashley-Koch 1 , X. Qin 1 , J.
Gibson 1 , Y. Liu 1, 2 , J. L. Wiggs 3 , J. E. Richards 4 ,
S. E. Moroi 4 , C. A. Girkin 5 , R. Allingham 2 , M.
A. Hauser 1, 2 . 1 Center for Human Genetics,
Duke University Medical Center, Durham, NC;
2
Department of Opthalmology, Duke University
Medical Center, Durham, NC; 3 Massachusetts Eye
and Ear Infirmary, Harvard Medical School, Boston,
MA; 4 Department of Ophthalmology and Visual
Sciences, University of Michigan Medical School,
Ann Arbor, MI; 5 Department of Ophalmology,
University of Alabama at Birmingham School of
Medicine, Birmingham, AL *CR
6240 — C0125 Secondary Glaucoma
in transthyretin (TTR)-related Familial
Amyloid Polyneuropathy. Antoine Rousseau 1 ,
E. Barreau 1 , G. Kaswin 1 , M. Mgarrech 1 , M.
Théaudin 2 , C. Cauquil 2 , D. Adams 2 , M. Labetoulle 1 .
1
Ophthalmology, Bicetre Hospital, South Paris
University, Le Kremlin Bicêtre, France; 2 Neurology,
Bicetre Hospital, South Paris University, Le
Kremlin Bicêtre, France *CR
6241 — C0126 Identification and expression
of candidate genes in pseudoexfoliation. Kamesh
Dhamodaran 1 , R. S. Shetty 1 , M. Subramani 1 , V.
Patil 2 , B. K. Shetty 2 , D. Das 1 . 1 Stem Cell Research
Laboratory, Narayana Nethralaya Post Graduate Inst
of Ophthalmology, Bangalore, India; 2 Cataract and
Refractive Lens Surgery, Narayana Nethralaya Post
Graduate Inst of Ophthalmology, Bangalore, India
6242 — C0127 Expanded Phenotype of
Axenfeld Spectrum: Congenital Hypothyroidism
and Glaucoma. Elena Bitrian 1 , E. W. McPherson 2 ,
A. L. Grajewski 1, 3 . 1 Ophthalmology, University of
Minnesota, Minneapolis, MN; 2 Genetics, Marshfield
Clinic, Marsfield, WI; 3 Pediatric Glaucoma, Bascom
Palmer Eye Institute, Miami, FL *CR
6243 — C0128 Candidate regulatory
lysyl oxidase-like 1 (LOXL1) variants in
pseudoexfoliation syndrome/glaucoma are
associated with differential LOXL1 expression.
Matthias Zenkel 1 , F. Pasutto 2 , J. Onderka 1 , A. W.
Krysta 1 , A. Moessner 1 , F. E. Kruse 1 , U. Schlotzer-
Schrehardt 1 . 1 Department of Ophthalmology,
University Erlangen Nuernberg, Erlangen,
Germany; 2 Department of Human Genetics,
University Erlangen Nuernberg, Erlangen, Germany
6244 — C0129 Spatial Distribution of
Mutations in ASB10 and MYOC. Colin Marrs 1 , S.
J. Garnai 1 , N. Lopes 1 , D. M. Reed 1 , K. E. Branham 1 ,
M. I. Othman 1 , S. E. Moroi 1 , J. R. Heckenlively 1 ,
H. S. Pawar 1 , J. E. Richards 1, 2 . 1 Ophthalmology
and Visual Sciences, University of Michigan, Ann
Arbor, MI; 2 Epidemiology, University of Michigan,
Ann Arbor, MI *CR
6245 — C0130 Conserved anatomic features
in sibling pairs concordant for angle closure.
Palaniswamy Krishnamurthy 1 , R. Venkatesh 1 , P. Y.
Ramulu 2 , S. Kavitha 1 , D. S. Friedman 2 , H. Quigley 2 ,
R. Wojciechowski 3 , F. Seager 2 . 1 Aravind Eye
Hospital, Pondicherry, India; 2 Wilmer Eye Institute,
Baltimore, MD; 3 Johns Hopkins Bloomberg School
of Public Health, Baltimore, MD *CR
6246 — C0131 Exome chip analysis identifies
rare variants associated with primary open angle
glaucoma. William K. Scott 1 , M. D. Courtenay 1 , D.
L. Budenz 3 , R. K. Lee 2 , J. L. Haines 4 , M. A. Pericak-
Vance 1 . 1 Hussman Institute of Human Genomics,
University of Miami, Miami, FL; 2 Bascom Palmer
Eye Institute, University of Miami, Miami, FL;
3
Ophthalmology, University of North Carolina,
Chapel Hill, NC; 4 Center for Human Genetics
Research, Vanderbilt University, Nashville, TN *CR
6247 — C0132 Association between IL1A,
IL1B and TNFA polymorphisms and glaucoma
in a Brazilian population. Mariana Oliveira 1, 2 , J.
C. Vasconcellos 2, 1 , V. P. Costa 2 , G. Ananina 1 , M. B.
Melo 1 . 1 Center of Molecular Biology and Genetic
Engineering, University of Campinas, UNICAMP,
Campinas, Brazil; 2 Department of Ophthalmology,
Faculty of Medical Sciences, University of
Campinas, UNICAMP, Campinas, Brazil
6248 — C0133 Functional Analysis of LOXL1
Missense Variants in the Pathophysiology of
Pseudoexfoliation Syndrome/Glaucoma. Ursula
Schlotzer-Schrehardt 1 , T. Sasaki 2 , M. Zenkel 1 ,
F. E. Kruse 1 , A. W. Krysta 1 . 1 Department of
Ophthalmology, University of Erlangen-Nürnberg,
Erlangen, Germany; 2 Department of Experimental
Medicine I, University of Erlangen-Nürnberg,
Erlangen, Germany
6249 — C0134 Mapping of two modifier loci
for glaucoma severity on chromosome 20. Vincent
Raymond 1, 2 , P. Belleau 1 , S. Dubois 1 , R. Arseneault 1 .
Shink 1, 2 , J. Anctil 3 , G. Côté 3 , M. A. Walter 4 , M.
Amyot 5 . 1 Neurosciences, CHU de Québec/CHUL
(Université Laval Hospital) Research Centre,
Québec City, QC, Canada; 2 Molecular Medicine,
Université Laval, Québec City, QC, Canada;
3
Ophthalmology, Université Laval, Québec City,
QC, Canada; 4 Medical Genetics, University of
Alberta, Edmonton, AB, Canada; 5 Ophthalmology,
Université de Montréal, Montréal, QC, Canada
Thursday Posters
10:30 am – 12:15 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
389

6250 – 6268 – Thursday – Posters
Thursday Posters
10:30 am – 12:15 pm
Exhibit Hall D0058-D0070
Thursday, May 09, 2013 10:30 AM-12:15 PM
Retina
543 Proliferative Vitreoretinopathy
Moderators: Francesco Boscia and
Dov Weinberger
6250 — D0058 Comparison of Gene Expression
Profile of Epiretinal Membranes obtained from
Eyes with Proliferative Vitreoretinopathy to that
of Secondary Epiretinal Membranes. Shigeo
Yoshida, R. Asato, T. Nakama, K. Ishikawa, S.
Nakao, Y. Sassa, H. Enaida, Y. Oshima, T. Ishibashi.
Ophthalmology, Kyushu University, Fukuoka-shi,
Japan
6251 — D0059 miR-135b Regulates TGFβ1-Mediates
Retinal Pigment Epithelial-
Mesenchymal Transition. Fang Wang, H. Li, M.
Li. Tenth People’s Hospital of Tongji University,
Shanghai, China
6252 — D0060 β-catenin signaling in RPE in
experimental PVR. Kazuhiko Umazume 1, 2 , L. Liu 1 ,
K. McDonald 1 , H. Goto 2 , H. J. Kaplan 1 , S. Tamiya 1 .
1
Ophthalmology & Visual Sciences, University of
Louisville, Louisville, KY; 2 Ophthalmology, Tokyo
Medical University, Tokyo, Japan
6253 — D0061 Periostin Promotes the
Generation of Fibrous Membranes in
Proliferative Vitreoretinopathy. Keijiro Ishikawa 1 ,
S. Yoshida 1 , S. Nakao 1 , T. Nakama 1 , T. Kita 1 , Y.
Sassa 1, 2 , H. Enaida 1 , Y. Oshima 1 , T. Kono 2 , T.
Ishibashi 1 . 1 Ophthalmology, Kyushu University,
Fukuoka, Japan; 2 Ophthalmology, Fukuoka
University Chikushi Hospital, Fukuoka, Japan
6254 — D0062 Suppression of Retinal
Pigment Epithelial Cell Proliferation, Migration
and Epithelial-mesenchymal transition by
Proteasome Inhibition, a Potential Defense
against Proliferative Vitreoretinopathy. Chuan
Chen 1 , Y. Zhu 1 , Y. Lin 1 , Z. Liu 1 , M. Wu 1 , D. W. Li 2 , B.
Cheng 1 . 1 Zhongshan Ophthalmic Center, Sun Yatsen
University, Guangzhou, China; 2 Biochemistry
and Molecular Biology, University of Nebraska
Medical Center, Omaha, NE
6255 — D0063 Factor Xa and thrombin induce
epithelial to mesenchymal transition by retinal
pigment epithelial cells via PDGF-signaling.
Jeroen Bastiaans 1 , J. C. van Meurs 2, 3 , C. van Holten
- Neelen 1 , P. M. Van Hagen 1, 4 , N. Nagtzaam 1 , H.
Hooijkaas 1 , W. A. Dik 1 . 1 Immunology, Erasmus
MC, Rotterdam, Netherlands; 2 The Rotterdam Eye
Hospital, Rotterdam, Netherlands; 3 Ophthalmology,
Erasmus MC, Rotterdam, Netherlands; 4 Internal
Medicine, Erasmus MC, Rotterdam, Netherlands
6256 — D0064 Aquaporin-1 Expression in
Membranes from Proliferative Vitreoretinopathy
and in Epiretinal Membranes. Laure E. Caspers 1 ,
E. Motulsky 1, 2 , D. Salik 1, 2 , X. Janssens 1, 3 , B. Pion 1, 3 ,
N. Bolaky 2 , F. Gregoire 2 , J. Perret 2 , F. Willermain 1, 4 ,
C. Delporte 2 . 1 Ophthalmology, CHU Saint-Pierre
Hospital - ULB, Brussels, Belgium; 2 Laboratory of
Pathophysiological and Nutritional Biochemistry,
Université Libre de Bruxelles (ULB), Brussels,
Belgium; 3 Ophthalmlogy, Saint-Anne Saint-
Rémi Hospital, Brussels, Belgium; 4 I.R.I.B.H.M,
Université Libre de Bruxelles (ULB), Brussels,
Belgium
6257 — D0065 Distribution of MDM2 T309G
polymorphism in European patients with
Proliferative Vitreoretinopathy. Retina 4 project.
Salvador Pastor 1, 2 , I. Rodriguez-Hernandez 2 , J.
Rojas Spano 1 , R. Gonzalez-Sarmiento 2 , J. Pastor 1 .
1
Ophthalmology, IOBA-University of Valladolid,
Valladolid, Spain; 2 Medicine, Molecular Medicine
Unit, IBMCC and IBSAL, Salamanca, Spain
6258 — D0066 Epithelial cells promote
fibroblast-mediated contraction of collagen gels
by secreting bFGF. Maryada Sharma, H. Lei,
S. Pennock, A. Kazlauskas. The Schepens Eye
Research Institute, Massachusetts Eye and Ear
Infirmary, Department of Ophthalmology, Harvard
Medical School, Boston, MA
6259 — D0067 Analysis of vitreous hyaluronan
status in viteroretinal diseases. Koichi Nishitsuka 1 ,
M. Narumi 1 , Y. Kashiwagi 2 , T. Shibata 3 , J. Gong 3 ,
H. Furukawa 3 , H. Yamashita 1 . 1 Ophthalmology/
Vis Sci, Yamagata University Sch of Med,
Yamagata-shi, Japan; 2 Yonezawa Women’s Junior
College, Yonezawa, Japan; 3 Mechanical Systems
Engineering, Graduate School of Science and
Engineering, Yamagata University, Yonezawa,
Japan *CR
6260 — D0068 Effect of SAHA on Fibrotic
Change in Primate Retinal Pigment Epithelium
Cells and Vitreous Cells. Hiroki Hatanaka 1 , N.
Okumura 2, 1 , N. Koizumi 2 , E. Mizuhara 2 , H. Hirano 2 ,
J. Hamuro 1 , S. Kinoshita 1 . 1 Ophthalmology, Kyoto
Prefectural Univ of Med, Kyoto, Japan; 2 Biomedical
Engineering, Faculty of Life and Medical Sciences,
Doshisha University, kyotanabe, Japan *CR
6261 — D0069 Immunospecific targeting of
fibronectin towards an anti-fibrotic therapy,
with special emphasis on proliferative
vitreoretinopathy (PVR). Manni Luthra-
Guptasarma 1 , M. Sharma 1, 3 , S. Sharma 1 , A. Tiwari 1 ,
V. Gupta 2 , A. Gupta 2 . 1 Immunopathology, PGIMER
Chandigarh, Chandigarh, India; 2 Ophthalmology,
PGIMER Chandigarh, Chandigarh, India; 3 The
Schepens Eye Research Institute; Department of
Ophthalmology and Visual Sciences, Harvard
Medical School, Boston, MA *CR
6262 — D0070 Novel Anti-CTGF RNAi
Therapy for Treatment of Proliferative
Vitreoretinopathy (PVR) and other Ocular
Disorders. Geoffrey P. Lewis 2 , M. Byrne 1 , S. K.
Fisher 2 , J. Cardia 1 , L. Pandarinathan 1 , K. Bulock 1 ,
L. Libertine 1 , P. A. Pavco 1 . 1 RXi Pharmaceuticals,
Westborough, MA; 2 Neuroscience Research
Institute, Univ of California Santa Barbara, Santa
Barbara, CA *CR
Exhibit Hall D0079-D0129
Thursday, May 09, 2013 10:30 AM-12:15 PM
Retina
544 AMD IV, RE
Moderator: Amani A. Fawzi
6263 — D0079 The Rod Intercept: An
Improved Method for Estimating Rod-Mediated
Dark Adaption Speed. John G. Edwards 1 , G. R.
Jackson 2 . 1 MacuLogix, Inc, Atlanta, GA; 2 Penn
State College of Medicine, Hershey, PA *CR
6264 — D0080 Specular Photomicrographic
Assessment of the Effect of Anti-VEGF
intravitreal injections on corneal thickness and
endothelial cell density (CD) and morphology.
Fayssal El-Jabali, G. Papastergiou, M. D. Bennett,
K. E. Waite. Ophthalmology - Retina, Retina
Institute of Hawaii, Honolulu, HI
6265 — D0081 Retinal and choroidal thickness
changes over time in patients with neovascular
age-related macular degeneration treated with
anti-VEGF. Thais S. Mendes, M. Menghini,
A. L. Levison, S. Rofagha, R. B. Bhisitkul.
Ophthalmology, UCSF, San Francisco, CA *CR
6266 — D0082 Is foveal RPE autofluorescence
a predictor of visual outcome in wet Age Related
Macular Degeneration patients treated with
Ranibizumab? Maria Dimitry, N. Jain, L. North,
M. N. Chandran, G. Menon. Frimley Park Hospital,
Frimley, United Kingdom *CR
6267 — D0083 Intravitreal anti-VEGF therapy
for vascularized serous pigment epithelial
detachment in age-related macular degeneration.
Lucia Finocchio, D. Bacherini, F. Giansanti, G.
Giacomelli, C. Mazzini, L. Vannozzi, I. Biagini, G.
Virgili, U. Menchini. Department of Specialistic
Surgical Sciences, Eye Clinic, University of
Florence, Florence, Italy
6268 — D0084 Outer Retinal Tubulations
in the Comparison of AMD Treatments Trials
(CATT). Joo Yong Lee 1, 2 , F. A. Folgar 1 , C. A.
Toth 1 , G. J. Jaffe 1 . 1 Duke Eye Center, Durham, NC;
2
Ophthalmology, Asan Medical Center, University
of Ulsan, Seoul, Republic of Korea *CR, f
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
390

Thursday – Posters – 6269 – 6287
6269 — D0085 Retinal Pigment Epithelium
Atrophy in Patients Receiving Intravitreal
Anti-Vascular Endothelial Growth Factor
Therapy for Neovascular Age-Related Macular
Degeneration. Luna Xu 1, 2 , S. Mrejen 1, 4 , R. Gallego-
Pinazo 1, 5 , J. J. Jung 1, 3 , M. Marsiglia 1, 4 , S. Boddu 3 ,
K. Freund 1, 3 . 1 Vitreous Retina Macula Consultants
of New York, New York, NY; 2 Department
of Medicine, St. Vincent’s Medical Center,
Bridgeport, CT; 3 Department of Ophthalmology,
New York University School of Medicine, New
York, NY; 4 LuEsther T. Mertz Retinal Research
Center, Manhattan Eye, Ear, and Throat Hospital,
New York, NY; 5 Department of Ophthalmology,
University and Polytechnic Hospital La Fe,
Valencia, Spain *CR
6270 — D0086 Aflibercept (Eylea) Effect
on Macula Thickness and Visual Acuity in
Exudative AMD Patients Recalcitrant to
Ranibizumab and Bevacizumab. Vincent Hau, M.
Samuel, M. Davis, K. Lin, T. Chang. Retina Institute
of California, Riverside, CA *CR
6271 — D0087 Comparison of Treatment
Schedules in an Integrated Analysis of the VIEW
Studies. Papp András 1 , B. Sommerauer 2 , O. Sowade 2 .
1
Department of Ophthalmology, Semmelweis
University Budapest, Budapest, Hungary; 2 Bayer
Healthcare, Berlin, Germany *CR, f
6272 — D0088 Early fluid clearance
following intravitreal ranibizumab injection for
neovascular age-related macular degeneration.
Kathy Jao 1 , D. S. Chauhan 2 . 1 Department of
Medicine, University of Melbourne, Melbourne,
VIC, Australia; 2 Vision Retinal Institute Eastern,
Melbourne, VIC, Australia *CR
6273 — D0089 ForeseeHome in AREDS2-
Home Monitoring of AMD patients: Study
Design, Enrollment, Baseline Characteristics
and Initial Device Usage. Michael J. Elman 1, 2 , S.
B. Bressler 2 , T. E. Clemons 3 , E. Y. Chew 4 . 1 Elman
Retina Group PA, Baltimore, MD; 2 Johns Hopkins
University School of Medicine, Baltimore, MD;
3
Emmes Corporation, Bethesda, MD; 4 National Eye
Institute, Bethesda, MD *CR
6274 — D0090 Predictive Factors for
Visual Acuity “Gain and Maintain” after
Ranibizumab Treatment for Age-Related
Macular Degeneration and Polypoidal Choroidal
Vasculopathy. Yuji Oshima, S. Shiose, M. Yasuda,
K. Kano, A. Yoshida, K. Ishikawa, S. Notomi, S.
Yoshida, T. Ishibashi. Ophthalmology, Kyushu
Univ, Faculty of Med, Fukuoka, Japan *CR
6275 — D0091 Morphologic effects of anti-
VEGF therapy on retinal pigment epithelium
(RPE) and choroidal vasculature (CV) in
neovascular age-related macular degeneration
(AMD). Ursula Schmidt-Erfurth 1 , C. Schuetze 1 ,
S. M. Waldstein 1 , B. S. Gerendas 1 , C. Simader 1 ,
L. Zhang 3 , M. D. Abramoff 3 , M. Sonka 3 , B.
Baumann 2 , C. K. Hitzenberger 2 . 1 Department of
Ophthalmology, Medical University of Vienna,
Vienna, Austria; 2 Center for Medical Physics and
Biomedical Engineering, Medical University
of Vienna, Vienna, Austria; 3 Iowa Institute for
Biomedical Imaging, University of Iowa, Iowa City,
IA *CR
6276 — D0092 Association Between Required
Length of Intravitreal Anti-VEGF Therapy in
Exudative Age-Related Macular Degeneration
and Initial Central Macular Thickness as
Measured by Optical Coherence Tomography.
Blake Isernhagen, S. R. Fransen. Dean McGee Eye
Institute, Oklahoma City, OK
6277 — D0093 Quantification of the area of
retinal pigment epithelium tears in age-related
macular degeneration. Christoph R. Clemens,
F. Alten, C. Baumgart, P. Heiduschka, N. Eter.
Ophthalmology, University Eye Hospital, Muenster,
Germany *CR
6278 — D0094 Correlation Between Fluid
Status at Week 12 and Week 52 Following
Intravitreal Aflibercept Injections in the VIEW
Study of wAMD Patients. Jeffrey L. Marx 1 , D.
M. Moshfeghi 2 , S. M. Hariprasad 3 , J. S. Heier 4 .
1
Department of Ophthalmology, Lahey Clinic,
Peabody, MA; 2 Department of Ophthalmology,
Stanford University, Palo Alto, CA; 3 Department of
Ophthalmology, University of Chicago, Chicago,
IL; 4 Ophthalmic Consultants of Boston and Tufts
University School of Medicine, Boston, MA *CR, f
6279 — D0095 Wide Field Fluorescein
Angiography in Silicone Oil Filled Eyes.
Goran Bencic 1 , M. Zoric-Geber 1 , Z. Vatavuk 1 ,
T. R. Friberg 2 . 1 University Department of
Ophthalmology, University Clinical Hospital
“Sestre milosrdnice”, Zagreb, Croatia; 2 Retina
Service, UPMC Eye Center, University of
Pittsburgh, Pittsburgh, PA *CR
6280 — D0096 Impact of reticular
pseudodrusen on macular function. Giuseppe
Querques, N. Massamba, M. Srour, E.
Boulanger-Scemama, L. Querques, E. H. Souied.
Ophthalmology, University Paris Est Creteil, Cretil,
France *CR
6281 — D0097 Photoreceptor Abnormalities
in Intermediate Age-Related Macular
Degeneration. Sam Sadigh 1 , A. V. Cideciyan 1 , A.
M. Sumaroka 1 , W. Huang 1 , X. Luo 1 , M. Swider 1 ,
J. D. Steinberg 1 , D. Stambolian 2 , S. G. Jacobson 1 .
1
Ophthalmology, Scheie Eye Institute, University
of Pennsylvania, Philadelphia, PA; 2 Ophthalmology
and Genetics, University of Pennsylvania,
Philadelphia, PA
6282 — D0098 Individual Retinal Pigment
Epithelium Cells can be Imaged In Vivo in Age
Related Macular Degeneration. Ethan A. Rossi 1 ,
D. R. Williams 1, 2 , A. Dubra 4, 5 , L. R. Latchney 3 ,
M. A. Folwell 1 , W. Fischer 3 , H. Song 1 , M. M.
Chung 3, 1 . 1 Center for Visual Science, University of
Rochester, Rochester, NY; 2 The Institute of Optics,
University of Rochester, Rochester, NY; 3 Flaum Eye
Institute, University of Rochester, Rochester, NY;
4
Ophthalmology, Medical College of Wisconsin,
Milwaukee, WI; 5 Biophysics, Medical College of
Wisconsin, Milwaukee, WI *CR
6283 — D0099 Photoreceptor Structure in
Patients with Increased Genetic Risk for Age-
Related Macular Degeneration. Megan E. Land 3 ,
R. F. Cooper 4 , E. Berg 5 , T. Kitchner 6 , J. Young 1 , K.
E. Stepien 1 , T. B. Connor 1 , D. Page 7 , M. Brilliant 6 ,
J. Carroll 1, 2 . 1 Ophthalmology, Medical College
of Wisconsin, Milwaukee, WI; 2 Cell Biology,
Neurobiology & Anatomy, Medical College of
Wisconsin, Milwaukee, WI; 3 Medical College
of Wisconsin, Milwaukee, WI; 4 Biomedical
Engineering, Marquette University, Milwaukee,
WI; 5 Computer Sciences, University of Wisconsin
Madison, Madison, WI; 6 Center for Human
Genetics, Marshfield Clinic Research Foundation,
Marshfield, WI; 7 Biostatistics & Medical
Informatics, University of Wisconsin Madison,
Madison, WI *CR
6284 — D0100 Cellular Features of Retinal
Pigment Epithelial Atrophy after Regression of
Choroidal Neovascularization. Mina M. Chung 1, 2 ,
H. Song 2, 1 , L. R. Latchney 1 , M. A. Folwell 2 , W.
Fischer 1 , E. A. Rossi 2 . 1 Flaum Eye Institute,
University of Rochester, Rochester, NY; 2 Center for
Visual Science, University of Rochester, Rochester,
NY *CR
6285 — D0101 The role of Optical Coherence
Tomography (OCT) for the diagnosis,
monitoring, and guiding of treatment for
neovascular Age-related Macular Degeneration
(nAMD): an evidence synthesis study. Noemi
Lois 1 , A. Azuara-Blanco 2 , G. Mowatt 2 , M. M.
Castillo de Chacon 2 , A. Elders 2 , C. Ramsay 2 , J.
Burr 3 . 1 Ophthalmology Department, Grampian
Univ Hosp/NHS Trust, Aberdeen, United Kingdom;
2
Health Services Research Unit, University of
Aberdeen, Aberdeen, Scotland, United Kingdom;
3
School of Medicine, University of St Andrews, St
Andrews, United Kingdom
6286 — D0102 Towards Automated Assessment
of AREDS Severity Scale and Simple Scale Using
RTVue ® Spectral Domain Optical Coherence
Tomography Tools. Qienyuan Zhou 1 , Y. Wolfson 2 ,
V. Chaikitmongkol 2, 3 , N. M. Bressler 2 . 1 Optovue,
Inc., Fremont, CA; 2 Retina Division, Wilmer Eye
Institute, Johns Hopkins School of Medicine,
Baltimore, MD; 3 Department of Ophthalmology,
Chiang Mai University, Chiang Mai, Thailand *CR
6287 — D0103 Detachment of CNV from
Bruch membrane due to contraction of
fibrovascular membrane in AMD. Ryo Mukai, T.
Sato, S. Kishi, N. Hanyuda. Ophthalmology, Gunma
Graduate school of medicine, Gunma, Japan *CR
Thursday Posters
10:30 am – 12:15 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
391

6288 – 6310 – Thursday – Posters
Thursday Posters
10:30 am – 12:15 pm
6288 — D0104 Optical Coherence Tomography
and fluorescein angiography in the diagnosis
of choroidal neovascularization of age-related
macular degeneration. Ramin Tadayoni 1 ,
V. Gualino 1, 5 , S. Y. Cohen 1, 2 , G. Quentel 2 , B.
Haouchine 1, 3 , A. Erginay 1 , P. Massin 1 , E. Vicaut 4 , A.
Gaudric 1 . 1 Ophthalmology, Lariboisiere University
Hospital, Paris, France; 2 Centre d’imagerie et de
laser, Paris, France; 3 Centre d’exploration de la
vision, Rueil Malmaison, France; 4 Clinical Research
Unit, Lariboisiere University Hospital, Paris,
France; 5 Clinique du docteur Cave, Montauban,
France *CR, f
6289 — D0105 Optical Coherence
Tomographic Findings in Wet Age-Related
Macular Degeneration Refractory to
Bevacizumab after Intravitreal Aflibercept
Therapy. Carmel Moazez 1, 2 , K. Attaran-Rezaei 2 , C.
H. Sell 2, 1 , S. Bryan 2 , S. De Souza 2 , A. J. Gordon 2 ,
H. M. Kwong 2 , R. Reddy 2 , B. Shirkey 2 , M. C.
Ziemianski 2 . 1 University of Arizona College of
Medicine-Phoenix, Phoenix, AZ; 2 Associated Retina
Consultants, Phoenix, AZ
6290 — D0106 Inner Retinal Layers Damage
in Age-related Macular Degeneration. Ulfah
Rimayanti, K. Yamane, M. Latief, H. Mochizuki,
J. Hirata, Y. Kiuchi. Ophthalmology and Visual
Science Department, Hiroshima University,
Hiroshima, Japan
6291 — D0107 Comparison of spectral domain
and time domain OCT for qualitative and
quantitative fluid assessments in the Comparison
of AMD Treatments Trials (CATT). Francisco A.
Folgar 1 , C. A. Toth 1 , G. Ying 2 , M. G. Maguire 2 , G. J.
Jaffe 1 . 1 Ophthalmology, Duke University, Durham,
NC; 2 Ophthalmology, University of Pennsylvania,
Philadelphia, PA *CR, f
6292 — D0108 Optical coherence tomographic
correlates of angiographic subtypes of occult
choroidal neovascularization. Amirhossein
Hariri 1 , F. M. Heussen 1, 2 , M. Nittala 1 , S. Sadda 1 .
1
Doheny Eye Inst/Univ of Sthrn California, Los
Angeles, CA; 2 Charite - University Medicine Berlin,
Berlin, Germany *CR
6293 — D0109 One-year macular volume
change of the neurosensory retina in
intermediate AMD by SDOCT semi-automated
segmentation. Eric L. Yuan 1 , F. A. Folgar 1 , S. J.
Chiu 2 , S. Farsiu 1, 2 , C. A. Toth 1, 2 . 1 Ophthalmology,
Duke University, Durham, NC; 2 Biomedical
Engineering, Duke University, Durham, NC *CR
6294 — D0110 Vitelliform-Like Lesions
Associated with Type 1 Choroidal
Neovascularization. Sabah Shah 1, 2 , V. P. Shah 2,
1
, K. Freund 2, 1 . 1 Ophthalmology, New York
University, New York, NY; 2 Vitreous-Retina-
Macula Consultants of New York, New York, NY
*CR
6295 — D0111 The Role of Anti-VEGF
Therapy in the Development and Progression
of Geographic Atrophy in Patients with Wet
Age-Related Macular Degeneration. Justin Shaw,
P. H. Scharper. Ophthalmology, Sinai Hospital of
Baltimore, Krieger Eye Institute, Baltimore, MD
6296 — D0112 OCT Minimum Intensity as a
Predictor of Geographic Atrophy Enlargement.
Paul F. Stetson 1 , Z. Yehoshua 2 , C. A. Garcia Filho 2 ,
G. Gregori 2 , P. J. Rosenfeld 2 . 1 Carl Zeiss Meditec,
Dublin, CA; 2 Bascom Palmer Eye Institute,
University of Miami Miller School of Medicine,
Miami, FL *CR, f
6297 — D0113 Progression of Geographic
Atrophy Predicted by SD-OCT En Face Imaging
of the Outer Retina. Renata Portella Nunes 1, 2 ,
Z. Yehoshua 1 , A. A. Moshfeghi 1 , G. Gregori 1 ,
P. F. Stetson 3 , W. J. Feuer 1 , P. J. Rosenfeld 1 .
1
Ophthalmology, Bascom Palmer Eye Institute,
Miami, FL; 2 Ophthalmology, Federal University of Sao
Paulo, Sao Paulo, Brazil; 3 Research and Development,
Carl Zeiss Meditec, Dublin, CA *CR, f
6298 — D0114 Assessment of linearity of
growth in time in geographic atrophy secondary
to age-related macular degeneration. Jordi M.
Mones 1, 2 , M. Biarnes 1, 2 . 1 Centro Medico Teknon,
Institut de la Macula de la Retina, Barcelona, Spain;
2
Barcelona Macula Foundation, Barcelona, Spain
*CR, f
6299 — D0115 Enhanced Depth Imaging
Optical Coherence Tomography of the Choroid
in eyes with Geographic Atrophy secondary to
Age-related Macular Degeneration. Athanasios
Bezatis 1 , E. Becker 1 , C. K. Brinkmann 1 , S. Schmitz-
Valckenberg 1 , R. Fimmers 2 , M. Fleckenstein 1 , F.
G. Holz 1 . 1 Ophthalmology, University of Bonn,
Bonn, Germany; 2 Institute for Medical Biometry,
Informatics and Epidemiology, Bonn, Germany
*CR
6300 — D0116 A lack of delayed intraocular
pressure elevation after intravitreal injections
of ranibizumab for age-related macular
degeneration. Yusuke Ichiyama, T. Sawada, M.
Kakinoki, O. Sawada, Y. Saishin, H. Kawamura, M.
Ohji. ophthalmology, Shiga University of Medical
Science, Otsu, Japan *CR
6301 — D0117 Longterm effect of multiple
intravitreal anti VEGF injection on intraocular
pressure. Yoon Jeon Kim, K. Sung, Y. Chung, K.
Lee, S. Joe, J. Lee, J. Kim, Y. Yoon. Asan Medical
Center, Seoul, Republic of Korea *CR
6302 — D0118 Effect of an Intravitreal Anti-
VEGF Injection on the Dynamics of the Anterior
Segment. Jonathan Naysan 1 , T. Suthar 1 , R. M.
Lieberman 2 , J. Jonisch 1, 3 . 1 Ophthalmology, North
Shore - Long Island Jewish, Great Neck, NY;
2
Ophthalmology, Mount Sinai University Medical
Center, New York, NY; 3 Ophthalmology, Long
Island Vitreoretinal Consultants, Great Neck, NY
6303 — D0119 Intraocular pressure monitoring
in patients with ranibizumab development. Anna
Plyukhova, M. A. Karpilova, A. V. Kuznetsov, I. V.
Andreeva, O. A. Gabina, M. V. Budzinskaya, V. P.
Erichev, S. E. Avetisov. State Research Institute
of Eye Diseases of Russian Academy of Medical
Sciences, Moscow, Russian Federation *CR
6304 — D0120 Persistent ocular hypertension
following intravitreal injections. Emilie Agard, H.
El Chehab, I. Douma, G. Ract-Madoux, C. Dussart,
C. Dot. Ophthalmology, Hopital Desgenettes, Bron,
France f
6305 — D0121 Evaluating safety and efficacy
of intravitreal Ranibizumab injection in AMD
patients and recommendations to improve the
standards of AMD service. Yasir Khan, M. Kim,
S. Kang, S. George. Medical Retina, Western Eye
Hospital, Imperial College London, London, United
Kingdom *CR
6306 — D0122 The UNVEIL (Utilizing
raNibizumab intraVitrEal Injection in
reaL-world setting) study interim results:
Effectiveness and safety of ranibizumab in the
treatment of neovascular age-related macular
degeneration under real-life conditions in
patients from Africa, Asia and the Middle East.
Mohamed Mahgoub 1 , N. K. Yadav 2 , V. Mester 3 ,
K. E. Legodi 4 , H. Kim 5 , E. Wu 6 , S. Hristoskova 6 ,
S. DiTommaso 6 . 1 Ophthalmology, Ain Shams
University, Cairo, Egypt; 2 Narayana Nethralaya,
Bangalore, India; 3 Ophthalmology, Samaya
Specialized Center, Abu Dhabi, Saudi Arabia;
4
Ophthalmology, Medforum Medi-clinic, Pretoria,
South Africa; 5 Ophthalmology, Kangnam Sacred
Heart Hospital, Hallym University, Seoul, Republic
of Korea; 6 Novartis Pharma AG, Basel, Switzerland
*CR
6307 — D0123 Role of biomechanical
properties of fibrous coat of the eye in
intraocular pressure changes in patients after
intravitreal ranibizumab injections. Pilot study.
Ekaterina Chikun, M. A. Karpilova, A. V. Kuznetsov,
I. V. Andreeva, O. A. Gabina, A. Plyukhova, M. V.
Budzinskaya, V. P. Erichev, S. E. Avetisov. State
Research Institute of Eye Disease of Russian
Academy of Medical Sciences, Moscow, Russian
Federation *CR
6308 — D0124 Efficacy and Safety of 0.5 mg
or 2.0 mg Ranibizumab in Patients with Wet
Age-Related Macular Degeneration: HARBOR
2-Year Results. David W. Faber 1 , Z. Li 2 , P. Lai 2 .
1
Rocky Mountain Retina Consultants, Salt Lake
City, UT; 2 Genentech, South San Francisco, CA
*CR, f
6309 — D0125 Association of Systemic
Anticoagulation and Rate of Intraocular
Hemorrhage Following Intravitreal Anti-VEGF
Therapy for Age-related Macular Degeneration.
Joanna Olson 1 , I. U. Scott 1, 2 , D. Kerchner 1 , A.
Kunselman 2 . 1 Penn State Hershey Eye Center,
Hershey, PA; 2 Department of Public Health
Sciences, Penn State College of Medicine, Hershey,
PA *CR
6310 — D0126 Microbial spectrum of
endophthalmitis following intravitreal injection
versus pars plana vitrectomy. Michael Dollin, P.
P. Storey, J. D. Pitcher, J. Vander, J. Hsu, S. J. Garg.
Wills Eye Institute, Philadelphia, PA *CR
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
392

Thursday – Posters – 6311 – 6333
6311 — D0127 Index of Non Circularity
as a Predictor for Progression in Eyes with
Geographic Atrophy (GA). Ronald P. Danis, A.
Domalpally, E. Corkery, R. A. Shaw, A. R. Narkar, J.
White. Ophthalmology & Visual Sciences, Univ of
Wisconsin-Madison, Madison, WI *CR
6312 — D0128 Predictors for the progression
of geographic atrophy in patient with age-related
macular degeneration : fundus autofluorescence
study with modified fundus camera. Yong Jin
Jeong 1 , I. Hong 1 , J. Chung 1 , H. Kim 1 , S. Park 1, 2 .
1
Ophthalmology, Kangdong Sacred Heart Hospital,
Seoul, Republic of Korea; 2 Ophthalmology,
Columbia University Medical Center, New York,
NY
6313 — D0129 Directional kinetics of
geographic atrophy progression in age-related
macular degeneration with foveal sparing.
Monika Fleckenstein 1 , A. Böker 1 , C. K. Brinkmann 1 ,
S. Schmitz-Valckenberg 1 , R. Fimmers 2 , F. G. Holz 1 .
1
Department of Ophthalmology, University of Bonn,
Bonn, Germany; 2 Institute for Medical Biometry,
Informatics and Epidemiology, University of Bonn,
Bonn, Germany *CR, f
Exhibit Hall D0185-D0236
Thursday, May 09, 2013 10:30 AM-12:15 PM
Physiology/Pharmacology / Biochemistry/
Molecular Biology / Visual Neuroscience
545 Retina: Physiology and
Pharmacology
Moderators: Teresio Avitabile and
Michele Reibaldi
6314 — D0185 Functional Expression Of
TRPV Channels In The Retinal Endothelium.
Jennifer E. McNaughten, M. McGahon, G.
McGeown, T. M. Curtis. Queens University Belfast,
Belfast, United Kingdom
6315 — D0186 Further Studies On The Role Of
Arachidonic Acid Metabolites In The Regulation
Of Potassium-Induced [ 3 H]D-Aspartate Release
From Isolated Bovine Retinae By 5-epi-5-F3t-
Isoprostane. Jamal Jamil 1 , P. Bankhele 1 , A. Salvi 1 ,
T. Durand 3 , J. Galano 3 , A. Guy 3 , Y. Njie-Mbye 2 , S.
E. Ohia 2 , C. A. Opere 1 . 1 Creighton.edu, Omaha,
NE; 2 Texas Southern University, Houston, TX;
3
Universities of Montpellier I and II, Montpellier
cedex, France
6316 — D0187 Protective effects of an PPAR-γ
agonist on retinal ischemia/reperfusion injury in
rats. Xiaoyan Zhang, Y. Xiao, Y. Zhang, J. Zhang,
W. Ye. Ophthalmology, Huashan Hospital affiliated
to Shanghai Fudan University, Shanghai, China
6317 — D0188 Spectroscopic Investigation
of Agonist-Induced Rearrangements of Cyclic
Nucleotide-Regulated Ion Channels. William N.
Zagotta 1 , M. C. Puljung 1 , S. Stoll 2 . 1 Physiology and
Biophysics, University of Washington, Seattle, WA;
2
Chemistry, University of Washington, Seattle, WA
6318 — D0189 Evaluation of homocysteine
and its metabolic cofactors in patients with
non proliferative and proliferative diabetic
retinopathy. Giulia Malaguarnera 1 , C. Gagliano 1 ,
M. D. Toro 1 , F. Drago 2 , T. Avitabile 1 . 1 Department
of Ophthalmology, university of Catania, Catania,
Italy; 2 Department of Clinical Biomedicine,
university of Catania, Catania, Italy
6319 — D0190 Increased Expression of
Endothelin B Receptors Precedes Retinal
Ganglion Cell Death in a Rodent Model of
Glaucoma. Alena Z. Minton 1, 2 , N. Phatak 1, 2 ,
D. L. Stankowska 1, 2 , S. He 1, 2 , H. Ma 3 , R. R.
Krishnamoorthy 1, 2 . 1 Cell Biology & Anatomy,
University of North Texas Health Science Center,
Fort Worth, TX; 2 North Texas Eye Research
Institute, Fort Worth, TX; 3 Pharmacology &
Neuroscience, University of North Texas Health
Science Center, Fort Worth, TX
6320 — D0191 Vitreous penetration of orally
administered acetazolamide in humans. Armin
Afshar, R. Jager. Ophthalmology & Visual Science,
University of Chicago, Chicago, IL
6321 — D0192 Quality of fixation in major
depressive disorder and the influence of
antipsychotic medication. Serena Fragiotta 1 , P.
Grenga 2 , D. Domanico 2 , A. Cutini 1 , S. Valente 1 ,
V. De Rosa 1 , E. M. Vingolo 1 . 1 University of Rome
La Sapienza, Latina, Italy; 2 S.M.Goretti Hospital,
latina, Italy
6322 — D0193 Translational Regulation
of RPE65 Expression by microRNA. William
Samuel 1 , R. K. Kutty 1 , T. Duncan 1 , C. Jaworski 1 ,
T. Hara 2 , A. Lal 2 , T. Redmond 1 . 1 Laboratory of
Retinal Cell and Molecular Biology, National Eye
Institute / National Institutes of Health, Bethesda,
MD; 2 Genetics Branch, National Cancer Institute /
National Institutes of Health, Bethesda, MD
6323 — D0194 Decreased Protein Expression
of P2X2 in the Retina of Type 1 Diabetic Rats
Treated with Suramin and PPADS. Juan E.
Gallo 2, 1 , J. Mancini 2, 1 , G. A. Ortiz 2 , J. O. Croxatto 3 .
1
Ophthalmology, Hospital Universitario Austral,
Pilar, Argentina; 2 Nanomedicine & Vision Group,
Universidad Austral, Pilar, Argentina; 3 Ocular
Pathology, Fundacion Oftalmologica Argentina
“Jorge Malbran”, Buenos Aires, Argentina *CR
6324 — D0195 Intracellular pH of Retinal
Ganglion Cells During Systemic Hypoxia. Verleen
K. McSween, S. Viswanathan, J. A. Bonanno, S.
A. Burns, S. Li. School of Optometry, Indiana
University, Bloomington, IN
6325 — D0196 Further Studies on the
Inhibition of [ 3
H]D-Aspartate Release by
Hydrogen Sulfide Donors in Isolated Bovine
Retina. Pratik Bankhele 1 , J. Jamil 1 , A. Salvi 1 , Y.
Njie-Mbye 2 , M. S. Kulkarni 2 , S. E. Ohia 2 , C. A.
Opere 1 . 1 Creighton University, Omaha, NE; 2 Texas
Southern University, Houston, TX
6326 — D0197 Asymmetrical vitreous status
in unilateral epimacular membrane observed
by swept-source optical coherence tomography.
Danjie Li, H. Itakura, S. Kishi. Ophthalmology,
Department of Ophthalmology, Gunma University
School of Medicine, Maebashi, Japan
6327 — D0198 The Retina of the Cognitively
Impaired Beagle Dog in Alzheimer’s Disease.
Laura Emptage 1 , B. Milgram 3, 5 , H. Dobson 3, 4 ,
Z. Leonenko 1, 6 , M. C. Campbell 1, 2 . 1 Physics and
Astronomy, University of Waterloo, Waterloo,
ON, Canada; 2 School of Optometry and Vision
Science, University of Waterloo, Waterloo, ON,
Canada; 3 CanCog Technologies, Fergus, ON,
Canada; 4 University of Guelph, Guelph, ON,
Canada; 5 University of Toronto at Scarborough,
Scarborough, ON, Canada; 6 Biology, University of
Waterloo, Waterloo, ON, Canada *CR
6328 — D0199 Acid Sphingomyelinase:
a novel target for ischemia-induced retinal
degeneration. Jie Fan 1 , B. X. Wu 2 , C. E. Crosson 1 .
1
Ophthalmology-Storm Eye Inst, Medical Univ of
South Carolina, Charleston, SC; 2 Microbiology &
Immunology, Medical University of South Carolina,
Charleston, SC *CR
6329 — D0200 Retinal Expression of
α-1-Antitrypsin (A1AT) in diabetic and
non-diabetic rats. Gustavo A. Ortiz 1, 3 , J.
Mancini 1, 3 , E. Chuluyan 2 , J. E. Gallo 1, 3 . 1 Ciencias
Biomédicas, Universidad Austral, Pilar, Argentina;
2
Farmacología, Universidad de Buenos Aires,
Buenos Aires, Argentina; 3 Nanomedicine & Vision
Group, Universidad Austral, Pilar, Argentina *CR
6330 — D0201 Dietary profile and vitamin
A intake in patients with Stargardt Disease
and Retinitis Pigmentosa. Alba Miele 1 , A. Sodi 1 ,
G. Abbruzzese 1 , V. Murro 1 , F. Sofi 3, 2 , F. Cesari 2 ,
A. Gori 2 , R. Abbate 2 , A. Casini 3 , U. Menchini 1 .
1
Specialistic Surgical Sciences, Eye Clinic,
University Of Florence, Italy, Florence, Italy, Italy;
2
Medical and Surgical Critical Care, University Of
Florence, Florence, Italy; 3 Agency of Nutrition,
University Of Florence, Florence, Italy
6331 — D0202 Hypothermia protects retinal
ganglion cells against ischemia. Maximilian
Schultheiss, M. Blak, T. Dorfi, J. Hofmann, K.
Bartz-Schmidt, S. Schnichels, M. S. Spitzer.
Department of Ophthalmology, University of
Tuebingen, Tuebingen, Germany *CR
6332 — D0203 Effect of Storage Temperature
and Antioxidant Concentration on
Catecholamine Stability. Randolph D. Glickman 1 ,
J. Berry 1, 2 , N. C. Kumar 1 . 1 Dept of Ophthalmology,
Univ of Texas Hlth Sci Ctr SA, San Antonio, TX;
2
Medical School, Baylor College of Medicine,
Houston, TX
6333 — D0204 Establishment of a retinal
ischemia organ culture model. Sven Schnichels,
M. Blak, T. Dorfi, J. Hofmann, K. Bartz-Schmidt, F.
Ziemssen, M. Schultheiss, M. S. Spitzer. University
Eye Hosp Tuebingen, Centre for Ophthalmology
Tuebingen, Tuebingen, Germany *CR
Thursday Posters
10:30 am – 12:15 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
393

6334 – 6356 – Thursday – Posters
Thursday Posters
10:30 am – 12:15 pm
6334 — D0205 Effects Of Propofol Over
Circular Retinal Spreading Depression. Vinicius
V. Oliveira 1 , R. Fleming 1 , N. S. Calixto 2 , S.
Cronemberger 2 , A. Dantas 1 . 1 Biophysics Institute,
Federal Univ of Rio de Janeiro, Rio de Janeiro,
Brazil; 2 Ophthalmology, Federal Univ of Minas
Gerais, Belo Horizonte, Brazil
6335 — D0206 Roles of Nitric Oxide in Delta
Opioid-Receptor Agonist (SNC 121) Mediated
Retina Neuroprotection in Chronic Glaucoma
Rat Model. Yasir Abdul, S. Husain. Ophthalmology,
Medical Univ of South Carolina, Charleston, SC
6336 — D0207 Perinatal hypoxia-ischemia
impairs retinal ganglion cell function and
optokinetic behavior in a rat model. Nikolay P.
Akimov, R. C. Renteria. Department of Physiology,
University of Texas Health Science Center at San
Antonio, San Antonio, TX
6337 — D0208 The effect of RGS9
overexpression on flicker responses of mouse
bipolar cells. Christopher Fortenbach 1 , C. Kessler 1 ,
M. E. Burns 1, 2 . 1 Center for Neuroscience and
Department of Cell Biology and Human Anatomy,
University of California at Davis, Davis, CA;
2
Ophthalmology & Vision Science, University of
California, Davis, Davis, CA
6338 — D0209 C-peptide injection had
synergitic effect to precultured islets transplant
in prevention of diabetic retinopathy. Chunzhi
Dou 1, 2 , S. Y. Wu 3 , X. Zhang 5 , T. Dou 6 , G. Shuyan 4 .
1
Ophthalmology, Emory University, Suwanee,
GA; 2 Biology, Georgia University System,
Lawrenceville, GA; 3 Department of Surgery,
Norman Bethune Medical School, Jilin University,
Changchun, China; 4 Department of Ophthalmology,
Norman Bethune Medical School, Jilin University,
Changchun, China; 5 Endocrinology, Dehui County
Hospital, Dehui, China; 6 Clinical Chemistry,
Genova Diagnostics, Duluth, GA
6339 — D0210 Comparison of
Dexmedetomidine vs. Propofol in Vitreoretinal
Surgery Under Local Block. Linda Y. Huang 1 , A.
Patel 2 , M. Antoniello 2 , C. Schoenberg 2 , D. Grech 2 ,
A. Davidow 2 , T. Xia 2 , N. Bhagat 1 . 1 Ophthalmology
and Visual Sciences, UMDNJ-New Jersey Medical
School, Newark, NJ; 2 Anesthesiology, UMDNJ-
New Jersey Medical School, Newark, NJ *CR, f
6340 — D0211 Sitagliptin prevents bloodretinal
barrier breakdown, inflammation
and neuronal cell death in the retina of type
1 diabetic animals. Andreia Gonçalves 1 , E. C.
Leal 2 , A. Paiva 3 , C. F. Ribeiro 1 , F. Reis 1 , A. F.
Ambrosio 2, 4 , R. Fernandes 1 . 1 Lab Pharmacology
and Experimental Therapeutics, IBILI - Faculty
of Medicine, University of Coimbra, Coimbra,
Portugal; 2 Centre for Neuroscience and Cell
Biology, University of Coimbra, Coimbra, Portugal;
3
Histocompatibility Centre of Coimbra, Coimbra
University Hospitals, Coimbra, Portugal; 4 Centre
of Ophthalmology and Vision Sciences, IBILI
- Faculty of Medicine, University of Coimbra,
Coimbra, Portugal
6341 — D0212 Inhibition of the diabetesinduced
increased TGF-β signaling in retinal
vessels leads to an abnormal endothelial
phenotype. Zeina Dagher, J. Vaz, M. Goodridge, C.
Gerhardinger, M. Lorenzi. Schepens Eye Research
Institute, Massachusetts Eye & Ear, Boston, MA
6342 — D0213 Expression of 2PK+ leak
channels in ganglion cells of the mouse retina.
Steven Hughes, R. G. Foster, S. N. Peirson, M.
W. Hankins. Nuffield Department of Clinical
Neurosciences, University of Oxford, Oxford,
United Kingdom
6343 — D0214 Glucocorticoids Inhibit
p38MAPK Activation and Neuronal Apoptosis in
Early Diabetic Retinopathy. Xinyuan Zhang 1 , B.
Bao 2 , M. C. Gillies 3 . 1 Tongren Eye Center, Beijing
Tongren Hospital, Beijing, China; 2 Pathology, The
University of Sydney, Sydney, NSW, Australia;
3
Ophthalmology, The University of Sydney, Sydney,
NSW, Australia *CR
6344 — D0215 The molecular mechanisms
of store-operated calcium entry in Müller glia.
Tunde Molnar 1 , A. M. Frye 1 , P. Barabas 1 , D. A.
Ryskamp 2, 1 , D. Krizaj 1, 3 . 1 Ophthalmology and
Visual Sciences, Moran Eye Institution, University
of Utah School of Medicine, Salt Lake City, UT;
2
Interdepartmental Program in Neuroscience,
University of Utah, Salt Lake City, UT; 3 Department
of Physiology, University of Utah, Salt Lake City,
UT
6345 — D0216 Contribution of GPCRs and
NADPH oxidase to increased generation of
superoxide by retinal photoreceptor cells in
elevated glucose. Yunpeng Du 1 , M. Cramer 1 , K.
Palczewski 2 , T. S. Kern 1, 3 . 1 Medicine, Case Western
Reserve University, Cleveland, OH; 2 Pharmacology,
Case Western Reserve University, Cleveland,
OH; 3 Stokes Veterans Administration Hospital,
Cleveland, OH *CR
6346 — D0217 Pro-NGF induces endothelial
cell death via the P75 neurotrophin receptor
(P75NTR) in a mouse model of oxygeninduced
retinopathy (OIR). Nicholas Sitaras 1, 2 ,
H. Saragovi 4 , S. Chemtob 3, 2 , P. Sapieha 2 .
1
Pharmacology, Maisonneuve-Rosemont Hospital,
Montréal-Est, QC, Canada; 2 Ophthalmology,
Maisonneuve-Rosemont Hospital, Montreal, QC,
Canada; 3 Pharmacology, CHU Sainte-Justine,
Montreal, QC, Canada; 4 Pharmacology and
Therapeutics, Lady Davis Institute, Montreal, QC,
Canada *CR
6347 — D0218 Inner nuclear layer microcystic
changes in optic nerve atrophy: a prospective
study. Benjamin Wolff, V. Vasseur, C. Basdekidou,
J. A. Sahel, C. Vignal, M. Mauget-Faÿsse. Professor
Sahel Dept, Fondation ophthalmologic Rothschild,
Paris, France *CR
6348 — D0219 Adrenergic but not purinergic
receptors affect ion transport across the mouse
retinal pigment epithelium. Thor Eysteinsson,
S. B. Skarphedinsdottir, S. Arnason. Physiology,
University of Iceland, Reykjavik, Iceland *CR
6349 — D0220 Increased Endothelin A
Receptor Expression in Rat Model of Ocular
Hypertension. Nolan R. McGrady 1, 2 , A. Z.
Minton 1, 2 , R. R. Krishnamoorthy 1, 2 . 1 Cell Biology &
Anatomy, UNT Health Science Center, Fort Worth,
TX; 2 North Texas Eye Research Institute, Fort
Worth, TX
6350 — D0221 Protective Effects of Chitosan
on Ischemia-Reperfusion Injury in Rat Retina.
Sheng-Li Cho 1 , C. Yang 2 . 1 National Taiwan
University College of Medicine, Taipei, Taiwan;
2
Department of Ophthalmology, National Taiwan
University Hospital, Taipei, Taiwan
6351 — D0222 Water-dispersible hesperetin
prevents ganglion cell loss in the retina after
retinal ischemia reperfusion injury. Akito
Shimouchi 1 , H. Yokota 1 , T. Nagaoka 1 , S. Ono 1 ,
H. Takumi 2 , S. Narayanan 3 , R. B. Caldwell 3, 4 , A.
Yoshida 1 . 1 Ophthalmology, Asahikawa Medical
University, Asahikawa, Japan; 2 Institute of Health
Science, Ezaki Glico Co., Ltd, Osaka, Japan;
3
Vascular Biology Center, Medical College of
Georgia, Augusta, Georgia; 4 VA Medical Center,
Augusta, Georgia *CR
6352 — D0223 Hypoxia Affects Polarized
Secretion of Amyloid Precursor Protein from
Retinal Pigmented Epithelial Cells. Mary C.
McGahan, S. Nagar, M. Lall. Dept of Molec
Biomed Sci, North Carolina State University,
Raleigh, NC
6353 — D0224 Stimulation of the AMPA
Receptor in Retinal Ganglion Cells Increases
Phosphorylation of CREB. Yong H. Park 1, 2 , B.
H. Mueller 1, 2 , H. Ma 1, 2 , T. Yorio 1, 2 . 1 Pharmacology
& Neuroscience, UNT Health Science Center, Fort
Worth, TX; 2 North Texas Eye Research Institute,
Fort Worth, TX
6354 — D0225 Specific Expression of
Erythrocyte tropomodulin in the retina of
E-Tmod+/lacZ and E-Tmod-/- mice. Lin Xie 1 ,
L. Sung 2 . 1 Department of Ophthalmology, DaPing
Hospital of the Third Military Medical University,
Chongqing, China; 2 Department of Bioengineering,
and Center for Molecular Genetics, University of
California, San Diego, CA
6355 — D0226 The Effects Of Brimonidine On
Retinal Spreading Depression. Renata Fleming 1 ,
V. V. Oliveira 1 , G. Alencar 1 , N. S. Calixto 2 , S.
Cronemberger 2 , P. Gardino 1 , A. Dantas 1 . 1 Instituto
de Biofísica Carlos Chagas Filho, Universidade
Federal do Rio de Janeiro, Rio de Janeiro, Brazil;
2
Universidade Federal de Minas Gerais, Belo
Horizonte, Brazil
6356 — D0227 Protective Effects of Renin
Inhibitor in Retinal Ischemia-reperfusion Injury.
Kazuyuki Hirooka, K. Tenkumo, E. Nitta, T. Fujita,
F. Shiraga. Ophthalmology, Kagawa Univ Faculty
of Medicine, Kita-gun, Japan
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
394

Thursday – Posters – 6357 – 6381
6357 — D0228 Brn3b mediated regeneration
of the optic nerve in a rodent model of glaucoma.
Dorota L. Stankowska, A. Z. Minton, R. R.
Krishnamoorthy. Cell Biology and Anatomy, North
Texas Eye Research Institute, University of North
Texas Health Science Center, Fort Worth, TX
6358 — D0229 Extracellular Hsp70
Mediates Ischemia-Induced Retinal Damage
Through A Tlr4-Dependent Pathway. Galina
Dvoriantchikova, A. C. Santos, X. Dvoriantchikova,
E. P. Hernandez, D. V. Ivanov. Bascom Palmer Eye
Institute, University of Miami Miller School of
Medicine, Miami, FL
6359 — D0230 AP-1 and C/EBPβ Regulate
Endothelin B (ET B
) Receptor in Retinas of
Rats in Response to Elevated Intraocular
Pressure. Shaoqing He 1 , A. Z. Minton 1 , H. Ma 2 , R.
R. Krishnamoorthy 1 . 1 Cell Biology and Anatomy,
University of North Texas Hlth Sci Ctr, Fort Worth,
TX; 2 Pharmacology and Neurosciences, University
of North Texas Hlth Sci Ctr, Fort Worth, TX
6360 — D0231 Mineralocorticoid receptor
antagonists for the treatment of central serous
chorioretinopathy: Mechanistic rationale.
Francine F. Behar-Cohen 1, 3 , I. Celerier 2 , E.
Bousquet 3, 1 , J. P. Jeanny 3 , F. Jaisser 2 , N. Farman 2 .
1
Ophthalmology, Hotel Dieu de Paris, Universite
Paris Descartes, Paris, France; 2 UMRS872 Team1,
Inserm, Paris, France; 3 UMRS 872 Team 17,
Inserm, Paris, France *CR
6361 — D0232 Ocular changes in a rat model
of Alzheimer’s Disease. YuChun Tsai 1 , B. Lu 1 , S.
Girman 1 , C. Svendsen 1 , R. M. Cohen 2 , S. Wang 1 .
1
Cedars-Sinai Medical Center, Los Angeles, CA;
2
Memory Disorders Center, Cedars-Sinai Medical
Center, Los Angeles, CA
6362 — D0233 QLT091001, a 9-cis-retinal
analog, is well tolerated by retinas of mice with
impaired visual cycles. Tadao Maeda 1 , Z. Dong 3 ,
H. Jin 3 , O. Sawada 2 , S. Gao 2 , G. Palczewska 3 , K.
Palczewski 2 . 1 Ophthalmology & Visual Sciences,
Case Western Reserve University, Cleveland, OH;
2
Pharmacology, Case Western Reserve University,
Cleveland, OH; 3 Polgenix Inc., Cleveland, OH *CR
6363 — D0234 Topical Bromfenac 0.1%
suppresses Concanavalin-A Induced Blood
Retinal Barrier Breakdown. Hiroaki Takahashi, T.
Kida, S. Kozai, H. Tokushige. Research Laboratory
for Drug Development, Senju Pharmaceutical Co,
Ltd, Kobe, Japan *CR
6364 — D0235 Overexpression of the
POU Domain Transcription Factor, Brn3b
Causes Neurite Outgrowth in Cultured PC 12
Cells. Nitasha Phatak, D. L. Stankowska, R. R.
Krishnamoorthy. UNT Health Science Center, Fort
Worth, TX
6365 — D0236 MicroRNAs in vitreous humor
from patients with ocular disease : preliminary
results. Caterina Gagliano 1 , A. Russo 2 , M.
Ragusa 4 , R. Caltabiano 3 , L. Puzzo 3 , T. Avitabile 2 ,
A. Longo 2 , M. D. Toro 2 , M. Purrello 4 , M. Reibaldi 2 .
1
Ophthalmology, NEST (Neurovisual Science
Technology), Catania, Italy; 2 Opthalmology,
University of Catania, Catania, Italy; 3 Pathological
Anatomy, University of Catania, Catania, Italy;
4
Molecular Biology, University of Catania, Catania,
Italy
Exhibit Hall D0277-D0293
Thursday, May 09, 2013 10:30 AM-12:15 PM
Eye Movements / Strabismus / Amblyopia /
Neuro-Ophthalmology
546 Oculoplastics: Eyelids
Moderator: Benjamin Thompson
6366 — D0277 A retrospective study of
chalazia in an urban tertiary care setting.
Christopher Lo, A. Y. Wu. Ophthalmology, Mount
Sinai, New York, NY
6367 — D0278 Clinical Pathology of Pediatric
Ptosis. Femida Kherani, E. Sanders, H. Sarnat.
University of Calgary, Calgary, AB, Canada
6368 — D0279 Comparison Of 10%
Phenylephrine Test with Manual Elevation Test
in Patients with Bilateral Involutional Ptosis.
Ivana Pereira, S. Matayoshi. Ophthalmology,
University Sao Paulo, Sao Paulo, Brazil
6369 — D0280 Ptosis following long term
topical steroid use after cornea graft surgery.
Amanjeet Sandhu, L. C. Clarke, F. C. Figueiredo.
Ophthalmology, Royal Victoria Infirmary,
Newcastle upon Tyne, United Kingdom
6370 — D0281 Effect of brow fixation in
evaluation of eyelid position and levator
palpebrae superioris function. Elysa A. Brown, A.
Y. Ting, I. Koreen, R. Yeatts. Ophthalmology, Wake
Forest Medical Center, Winston Salem, NC
6371 — D0282 Management of Malignant
Eyelid Tumors by Primary Reconstruction:
Evaluation of Long-term Outcomes. Yinan
Han 1 , J. Qian 1 , Y. Yuan 1 , Y. Bi 1 , Y. Yao 1 , K. Xue 1 ,
C. Wei 2 , J. Guo 1 . 1 Ophthalmology, Eye and ENT
Hospital of Fudan University, Shanghai, China;
2
Ophthalmology, Yijishan Hospital of Wannan
Medical College, Wuhu, China
6372 — D0283 Simplified horizontal mattress
full-thickness eyelid defect repair. Julia E.
Reid 1 , C. N. Czyz 2 , K. R. Everman 2 , K. V. Cahill 2 ,
J. A. Foster 2 , S. X. Zhang-Nunes 2 . 1 Department of
Ophthalmology and Visual Sciences, The Ohio
State University, Columbus, OH; 2 The Eye Center
of Columbus, Columbus, OH
6373 — D0284 Horizontal Tarsal Transposition
Flap and Lateral Canthal Fixation for Repair
of Large, Central Lower Eyelid Defects.
Clifton Blake Perry, K. D. Carter, R. C. Allen.
Ophthalmology, University of Iowa, Iowa City, IA
6374 — D0285 A modified staged surgical
intervention for blepharophimosis-ptosisepicanthus
inversus syndrome: 125 cases
with encouraging results. Xin Song, X. Fan.
Ophthalmology, Ninth People’s Hospital, Shanghai
Jiao Tong University School of Medicine, Shanghai,
China
6375 — D0286 Lower eyelid surgical approach
in facial paralysis. Fabiola Ogaz, G. Salcedo, R.
O. Prieto, A. Buigues, L. Guakil. Asociacion para
Evitar la Ceguera en Mexico, mexico, Mexico
6376 — D0287 Comparison of Fasanella-Servat
and Small-Incision Techniques for Involutional
Ptosis Repair. Mahsa A. Sohrab, G. Lissner.
Ophthalmology, Northwestern University, Chicago,
IL
6377 — D0288 Frontalis Suspension for
Blepharoptosis Surgery, Is there a best material?
Cristian M. Montecinos, R. O. Prieto, A. Ceriotto,
A. Buigues, A. I. Ortiz, G. Salcedo. APEC, Distrito
Federal, Mexico
6378 — D0289 Use of Histoacryl as a Spacer in
the Recession of Upper Eyelid Retraction. Imtiaz
A. Chaudhry 1 , O. Al-Shaikh 2 , W. A. Al-Rashed 3 ,
F. A. Shamsi 4 , Y. O. Arat 5 , M. Boniuk 6 . 1 Houston
Oculoplastics Associates, Memorial Herman
Medical Plaza Texas Medical Center, Houston, TX;
2
Oculoplastic and Orbit Division, King Khaled Eye
Specialist Hospital, Riyadh, Saudi Arabia; 3 Vice
Dean, Faculty of Medicine, Imam Ibn Mohammad
Saud Islamic University, Riyadh, Saudi Arabia;
4
Research Department, King Khaled Eye Specialist
Hospital, Riyadh, Saudi Arabia; 5 Department of
Ophthalmology, University of Wisconsin School of
Medicine, Madison, WI; 6 Ophthalmology, Baylor
College of Medicine, Houston, TX
6379 — D0290 Use of Omentum for
Engineering in vivo Levator Palpebrae
Superioris: A Pilot Study. Sara L. Duke, P. Bu, D.
K. Yoo. Ophthalmology, Loyola University Chicago,
Maywood, IL
6380 — D0291 Biointegration of Osteomesh ®
Polycaprolactone Implants in the Rabbit Eyelid.
Livia Teo 1 , S. Teoh 2 , L. Seah 1 . 1 Oculoplastics,
Singapore National Eye Center, Singapore,
Singapore; 2 Division of Bioengineering, School of
Chemical and Biomedical Engineering, Nanyang
Technological University, Singapore, Singapore
*CR
6381 — D0292 The Effects of Temperaturesensitive
Guardix SG ® in Adhesiolysis of
Experimentally Induced Lid Adhesion Rabbits.
Hee-Bae Ahn 1 , H. Jung 1 , M. Roh 2 , W. Ryu 1 , Y.
Kwon 1 . 1 ophthalmology, Dong-A university, Busan,
Republic of Korea; 2 pathology, Dong-A university,
Busan, Republic of Korea
Thursday Posters
10:30 am – 12:15 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
395

6382 – Thursday – Posters
6382 — D0293 The Efficacy of Seprafilm ®
Graft with Adhesiolysis in Experimentally
Induced Lid Adhesion in Rabbits. Hyemi Jung 1 ,
H. Ahn 1 , M. Roh 2 , W. Ryu 1 , Y. Kwon 1 . 1 Department
of Ophthalmology, Dong-A University College of
Medicine, Busan, Republic of Korea; 2 pathology,
Dong-A University College of Medicine, Busan,
Republic of Korea
Thursday Posters
10:30 am – 12:15 pm
The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/2013/ProgramSummary/Index.
396

Thursday – Keynote – 6383
6B
Thursday, May 09, 2013 2:00 PM-3:15 PM
548 ARVO/Alcon Keynote Series
The Global Burden of Diseases, Injuries, and Risk
Factors Study 2010 (GBD 2010) is a systematic,
scientific effort to quantify the comparative
magnitude of health loss due to diseases, injuries
and risk factors by age, sex and geography for
specific points in time. Drawing on the efforts of
a multitude of people, including almost 500 coauthors
around the world, the study represents the
largest review of epidemiological data sources
relevant to burden of disease. After a complete
systematic assessment of the data on all diseases
and injuries, we have expanded the number of data
sources in our analysis significantly. GBD studies
for 1990 and 2000 examined 108 diseases and
causes in 8 regions and 170 diseases and causes
in 14 regions respectively. The GBD 2010 study
expands the scope much further to 291 diseases
and injuries and 67 risk factors in 21 individually
distinct but collectively comprehensive global
regions. At the same time, we have improved upon
estimation methods significantly. Amongst the
important differences: we have utilized population
level surveys to help derive health severity weights;
have used highly advanced published methods
to establish mortality by age and sex; and have
radically improved the modeling techniques
used for estimating incidence, prevalence and
causes of death. We have created new estimates
for 1990 using these techniques and the widely
expanded data available to us so that we can assess
comparable time trends with the best possible
science. This presentation will highlight key
findings from the GBD 2010, with a focus on
vision loss in the context of the other diseases,
injuries and risk factors studied, to demonstrate
this impairment’s global impact over the past two
decades and implications for future vision research.
Murray is a scholar in global health and public
health at the University of Washington and is the
director of IHME. He previously served as director
of the Harvard Initiative for Global Health and
executive director of the Evidence and Information
for Policy Cluster at the World Health Organization.
At IHME, Murray’s work has included studying
adult and child mortality, costs of various health
interventions, and continuing work with colleagues
at Harvard, WHO and elsewhere on the global
burden of disease project.
6383 — 2:00 Global Burden of Disease Study
2010: Key Findings and Implications for Vision
Research. Christopher Murray. Institute for Health
Metrics and Evaluation, University of Washington,
Seattle, WA
Thursday Keynote
2:00 pm – 3:15 pm
f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures.
397

NOTES
NOTES
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
_____________________________________________________________________________________________________________
398 266