A simple method for measuring glomerular filtration rate in dogs

A simple method for measuring glomerularfiltration rate in dogs 123
ACKNOWLEDGEMENTS
The authors would like to acknowledge the help which
they have received from Dr P. M. Webbon, Miss N.
Manfield, Miss R. Leahy, Mr A. J. Wagstaff, Mrs R.
Forster and the clinicians and owners who sought further
investigation of their clinical cases; they are particularly
grateful to Hills Pet Products for supporting this work and
to Miss H. Brooks for the art work.
REFERENCES
ALLEN, T. A., JAENKE, R. S. & FETTMAN, M. J. (1987) A technique for estimating
progression of chronic renal failure in the dog. Journal of the American
Veterinary Medical Association 190, 866-867
BARRATT, T. M. (1985) The kidney in childhood. In Postgraduate Nephrology. Ed
F. Marsh. London, W. Heinemann Medical Books. pp 459-498
BIEWENGA, W. J. & VAN DEN BROM, W. E. (1981) Assessment of glomemlar
filtration rate in dogs with renal insufficiency: analysis of the 51 Cr-EDTA clearance
and its relation to the plasma concentrations of urea and creatinine. Research
in Veterinary Science 30, 158-160
BOER, P. (1984) Estimated lean body mass as an index for normalization of body
fluid volumes in man. American Journal of Physiology 247, F632-F635
BROCHNER-MORTENSEN, J. (1972) A simple method for the determination of
glomerular filtration rate. Scandinavian Journal of Clinical Laboratory
Investigation 30, 271-274
BROCHNER-MORTENSEN, J. (1980) A simple single injection method for determination
of the extracellular fluid volume. Scandinavian Journal of Clinical
Laboratory Investigation 40, 567-573
BROCHNER-MORTENSEN, J. (1982) The extracellular fluid volume of normal
man determined as the distribution volume of 51 -Cr EDTA. Scandinavian Journal
of Clinical Laboratory Investigation 42, 261-264
BROCHNER-MORTENSEN, J. & DITZEL, J. (1982) Glomemlar filtration rate and
extracellular fluid volume in insulin-dependent patients with diabetes mellims.
Kidney International 21, 696-698
COHEN, M. L. (1974) Radionuclide clearance techniques. Seminars in Nuclear
Medicine 4, 23-37
EPSTEIN, M. E., BARSANTI, J. A., FINCO, D. R. & COWGILL, L. M. (1984)
Post-prandial changes in plasma urea nitrogen and plasma creatine in dogs fed
commercial diets. Journal of the American Animal Hospitals Association 20,
779-782
FINCO, D. R., COULTER, D. B. & BARSANTI, J. A. (1981) Simple, accurate
method for clinical estimation of glomerular filtration rate in the dog. American
Journal of Veterinary Research 42, 1874-1877
GROTHS, S., CHRISTENSEN, A. B. & NIELSEN, H. (1983) CdTe-detector registration
of 99mTc-DTPA clearance. European Journal of Nuclear Medicine 8, 242-
244
KRAWIEC, D. R., BADERTSCHER, R. R., TWARDOCK, A. R., RUBIN, S. I. &
GELBERG, H. B. (1986) Evaluation of 99mTc-diethylenetriamine-pentacetic acid
nuclear imaging for quantitative determination of the glomerular filtration rate of
dogs. American Journal of Veterinary Research 47, 2175-2179
KRAWIEC, D. R., TWARDOCK, A. R,, BADERTSCHER, R. R., DANIEL, G. B.
& DUGAN, S. J. (1988) Use of 99mTe-diethylenetriamine-pentacetic acid for
assessment of renal function in dogs with suspected renal disease. Journal of the
American Veterinary Medical Association 192, 1077-1080
LABATO, M. A. & ROSS, L. A. (1991) Plasma disappearance of creatinine as a
renal function test in the dog. Research in Veterinary Science 50, 253-258
LEVEY, A. S. (1990) Measurement of renal function in chronic renal disease.
Kidney lnternationa138, 167-184
LEVEY, A. S., PERRONE, R. D. & MADIAS, N. E. (1988) Serum creatinine and
renal function. Annual Review of Medicine 39, 465-490
McAFEE, J. G., GROSSMAN, Z. D., GANGE, G., ZENS, A. L., SUBRAMANIAN,
G., THOMAS, F. D., FERNANDEZ, P. & ROSKOPF, M. L. (1981) Comparison
of renal extraction efficieneies for radioactive agents in the normal dog. Journal of
Nuclear Medicine 22, 333-338
McCANCE, R. A. & WIDDOWSON, E. M. (1952) The correct basis on which to
compare infant and adult renal function. Lancet 2, 860-862
MULLIGAN, J. S., BLUE, P.W. & HARSBARGEN, J. A. (1990) Methods for measuring
GFR with TC99-DTPA. An analysis of several common methods. Journal of
Nuclear Medicine 31, 1211-1219
PERRONE, R. D. (1992) Means of evaluation of renal disease progression. Kidney
International 41, $26-$32
PETERS, A. M. (1992) Expression glomemlar filtration rate in terms of extracellular
fluid volume. Nephrology, Dialysis and Transplantation 7, 205-210
PETERS, A. M., GORDON, I. & SIXT, R. (1994) Normalisation of glomerular
filtration rate in children; body surface area, body weight or extracellular fluid
vohnne? Journal of Nuclear Medicine 35, 438-444
REHLING, M., MOLLER, M. L., THOMDROP, B., LUND, J. V. & TRAP-JENSEN,
J. (1984) Simultaneous measurement of renal clearance and plasma clearance of 99
Tc-DTPA and 51 Cr-EDTA and inulin in man. Clinical Science 66, 613-619
ROBBINS, M. E. C. (1984) Single injection techniques in determining age-related
changes in porcine renal function. International Journal of Applied Radiation and
Isotopes 35, 85-91
ROBINSON, T., HARBINSON, M. & BOVEE, K. C. (1974) Influence of reduced
renal mass on tubular secretion of ereatinine in the dog. American Journal of
Veterinary Research 5, 487-489
ROGERS, K. S., KOMKOV, A., BROWN, S. A., LEES, G. E., HIGHTOWER, D. &
RUSSO, E. A. (I991) Comparison of four methods of estimating glomerutar illtration
rate in cats. American Journal of Veterinary Research 52, 961-964
SAMPSON, C. B. & KEEGAN, J. (1985) Stability of 99Tc-DTPA injection: effect of
delay after preparation, dilution, generator oxidant, air and oxygen. Journal of
Nuclear Medicine Communications 6, 313-318
UPdBE, D., KRAWIEC, D. R., TWARDOCK, A. R. & GELBERG, H. B. (1992)
Quantitative renal scintigraphic determination of the glomerular filtration rate in
cats with normal and abnormal kidney function using 99mTc-diethytenetriaminepeutacetie
acid. American Journal of Veterinary Research 53, 1101 - 1107
VAN DEN BROM, W. E. & BIEWENGA, W. L (1981) Assessment of glomemlar
filtration rate in normal dogs: analysis of the 51Cr-EDTA clearance and its relation
to several endogenous parameters of glomerular filtration. Research in Veterinary
Science 30, 152-157
WALSER, M., DREW, H. H. & LaFRANCE, N. D. (1989) Reciprocal creatinine
slopes often give erroneous estimates of progression of chronic renal failure.
Kidney International 36, $81 -$85
WALSH, D. M. & ROYAL, H. D. (1992) Evaluation of a single injection of 99Tc-
DTPA for measuring glomemlar filtration rate in horses. American Journal of
Veterinary Research 53, 776-780
WHITE, A. 3. & STRYDOM, W. J. (1991) Normalization of glomerular filtration
rate measurements. European Journal of Nuclear Medicine 18, 385-390
Received January 18, 1994
Accepted December 8, 1994