Absite Review Series: Adrenal Gland Disorders
Absite Review Series: Adrenal Gland Disorders
Absite Review Series: Adrenal Gland Disorders
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www.downstatesurgery.org<br />
<strong>Adrenal</strong> Insufficiency in Sepsis<br />
Acute reversible dysfunction of HPA<br />
axis<br />
>30% in critically ill patients<br />
• <strong>Adrenal</strong> ACTH resistance<br />
• Decreased sensitivity of target tissues<br />
Vasopressor dependent septic shock<br />
may benefit from 5 to 7 day course of<br />
physiologic dose steroids<br />
Minneci PC, Deans KJ, Banks SM, et al: Meta-analysis: The effect of steroids on survival and<br />
shock during sepsis depends on the dose. Ann InternMed 2004; 141:47-56.
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