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LUTS-BPH and ED<br />

Common Risk Factors and Comorbidities<br />

Risk Factors<br />

• Increasing LUTS severity<br />

or symptom worsening<br />

• Increasing serum<br />

dihydrotestosterone<br />

• Enlarged prostate; >30<br />

mL<br />

• Inflammation<br />

• Elevated IPSS<br />

• Refractory to treatment<br />

• Poor flow<br />

• Genetics<br />

• History of AUR<br />

• High waist circumference<br />

• Increasing age<br />

• PSA >1.5 ng/dL<br />

• PVR >50 mL<br />

• Increasing bother<br />

• Reduced physical activity<br />

LUTS-BPH<br />

Comorbidities<br />

• Cardiovascular disease<br />

• Diabetes/Disrupted glucose<br />

homeostasis<br />

• Erectile dysfunction<br />

• Metabolic syndrome<br />

• Obesity<br />

Risk Factors<br />

• Increasing age<br />

• Smoking<br />

• High waist<br />

circumference<br />

ED<br />

Comorbidities<br />

• Cardiovascular disease<br />

• Depression<br />

• Diabetes<br />

• Hypercholesterolemia<br />

• Lower urinary tract<br />

symptoms<br />

• Metabolic syndrome<br />

• Obesity<br />

AUR, acute urinary retention.<br />

Lee RK, et al. BJU Int. 2012;110(4):540-455. PMID: 22243806; Parsons JK. Curr<br />

Bladder Dysfunct Rep. 2010;5(4):212-218. PMID: 21475707; Robert G, et al.<br />

Curr Opin Urol. 2011;21(1):42-48. PMID: 21045706; Roehrborn CG. BJU Int.<br />

2006;97(S2):7-11. PMID: 16507046; Rosen R, et al. Eur Urol. 2003;44(6):<br />

637-649. PMID: 14644114 ; Shabsigh R, et al. BMC Urol. 2010;10:18. PMID:<br />

21054874; Woo HH, et al. Med J Aust. 2011;195(1):34-39. PMID: 21728939.

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