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New Drug Update 2010-2011 Faculty Disclaimer - CME Conferences

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2 nd Annual Essentials in Primary Care<br />

Fall Conference<br />

Friday, November 11, <strong>2011</strong><br />

Liraglutide – Victoza<br />

Pancreatitis: Warnings and Precautions<br />

• In five clinical trials including more than 3,900<br />

people, there were seven cases of pancreatitis in<br />

patients using liraglutide and one case in a patient<br />

using another diabetes medicine. This constituted a<br />

4:1 imbalance of pancreatitis cases, when<br />

considering the number of patient exposures (2.2 vs.<br />

0.6 cases per 1000 patient-years).<br />

• Patients taking liraglutide should be aware of the<br />

symptoms of pancreatitis, such as severe abdominal<br />

pain that may also radiate into the back, possibly<br />

with nausea, and vomiting.<br />

Liraglutide – Victoza<br />

Adverse Effects in Clinical Trials %__<br />

• Nausea 28.4<br />

• Diarrhea 17.1<br />

• Vomiting 10.9<br />

• Constipation 9.9<br />

• Upper Respiratory Tract Infection 9.5<br />

Wayne Weart<br />

<strong>New</strong> <strong>Drug</strong> <strong>Update</strong> Part I

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