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New Drug Update 2010-2011 Faculty Disclaimer - CME Conferences

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2 nd Annual Essentials in Primary Care<br />

Fall Conference<br />

Friday, November 11, <strong>2011</strong><br />

Proposed Recommendations for Use of<br />

Metformin Based on e-GFR<br />

Diabetes Care <strong>2011</strong>;34:1435<br />

eGFR (ml/min per 1.73m2)<br />

Action<br />

>60 No renal contraindication to metformin<br />

>45 Continue use<br />

Increase monitoring of renal function (every 3–6<br />

months)<br />

30 Prescribe metformin with caution<br />

Use lower dose (e.g., 50%, or half-maximal dose)<br />

Closely monitor renal function (every 3-6 months) Do<br />

not start new patients on metformin<br />

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