New Drug Update 2010-2011 Faculty Disclaimer - CME Conferences
New Drug Update 2010-2011 Faculty Disclaimer - CME Conferences
New Drug Update 2010-2011 Faculty Disclaimer - CME Conferences
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2 nd Annual Essentials in Primary Care<br />
Fall Conference<br />
Friday, November 11, <strong>2011</strong><br />
Citalopram hydrobromide (Celexa)<br />
Safety Alert<br />
August 24, <strong>2011</strong> FDA <strong>Drug</strong> Safety<br />
Communication: Abnormal heart rhythms<br />
associated with high doses of citalopram.<br />
• Previously doses up to 60 mg per day were<br />
FDA approved but based upon new data and<br />
case reports of dose related QT interval<br />
prolongation, leading to an abnormal heart<br />
rhythm (including Torsade de Pointes),<br />
citalopram should no longer be used at doses<br />
greater than 40 mg per day.<br />
Citalopram hydrobromide (Celexa)<br />
Safety Alert<br />
• Patients at particular risk for developing prolongation<br />
of the QT interval include those with underlying<br />
heart conditions and those who are predisposed to<br />
low levels of potassium and magnesium in the blood.<br />
• Studies have not shown a benefit in the treatment of<br />
depression at doses higher than 40 mg per day.<br />
• Citalopram and sertraline are the recommended<br />
agents of choice for patients with depression and<br />
CVD according to the AHA/APA<br />
– Circulation 2008;118:1768-75<br />
Wayne Weart<br />
<strong>New</strong> <strong>Drug</strong> <strong>Update</strong> Part I