Evaluation of the Antimicrobial and Cytotoxic Activity of Epiphany ...

Egyptian Journal of Medical Microbiology, January 2007 Vol. 16, No. 1
reaction leading to the elution of cytotoxic
substances.
In conclusion, Epiphany sealer demonstrates
a clear antibacterial activity, particularly
against E.faecalis which is the one of the
most resistant endodontic flora. However it
had no activity against fungi (C.albicans), so
the emergence of yeast with resistance to
Epiphany sealer warrants continued, prudent
monitoring .
The cytotoxicity of Epiphany was
comparable to that of EndoFill and Apexit, on
the other hand it was less toxic than Ketac-
Endo and AH-26.
Further in vivo studies are needed
to confirm the value of Epiphany sealer using
a root model.
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