Influence of the Processes Parameters on the Properties of The ...

Figure 8.2: Micrographs <strong>of</strong> PLGA 85:15 (RG 858 S) processed at P sat =100 bars, t sat =20 min and dP/dt =3 bar/s.
.................................................................................................................................................... 213
Figure 8.3: Size distributions <strong>of</strong> <strong>the</strong> ground and sieved particles <strong>of</strong> PLGA 85:15 . ............................................ 213
Figure 8.4: Comparison <strong>of</strong> micrographs <strong>of</strong> foams with different polymer particle size range processed at
scCO 2 condition T sat 48°C, t sat 20 min, dP/dt 3 bar/s, P sat 120 bars or P sat 100 bars. .... 214
Figure 8.5: Effect <strong>of</strong> particle size on equivalent pore size and geometric porosity <strong>of</strong> PLGA 85:15 foams
processed at T sat 48°C, t sat 20 min and dP/dt 3bar/s ........................................................... 215
Figure 8.6: Size distribution <strong>of</strong> composite formulation at different co-grinding time. .................................. 216
Figure 8.7: Micrographs <strong>of</strong> PLGA 85:15 composites foams processed at T sat = 50 o C, P sat = 100 bars, t sat = 20
min, and dP/dt = 3 bar/s with different co-grinding times. ........................................................ 216
Figure 8.8: Micrographs <strong>of</strong> foams with different filler ratio processed at five different scCO 2 conditions. . 218
Figure 8.9: Micrographs <strong>of</strong> foams <strong>of</strong> polymer with different particle size range +5% βTCP (sr) + 5% ATCP (sr)
processed at. T sat 45°C, P sat 100 bars, t sat 20 min and, dP/dt 3 bar/s. .............................. 219
Figure 8.10: Effect <strong>of</strong> particle size on Pore diameter and porosity <strong>of</strong> foams containing 90% PLGA 85:15
+5%βTCP (sr) and 5%ATCP (sr) processed at--[45 o C-100 bar-20 min-3 bar/s] ............................. 220
Figure 8.11: ScCO 2 Foaming installation with 3 perforated stailess steel plates stage. ................................ 220
Figure 8.12: Foams <strong>of</strong> polymer composite blend on 3 SS plates stage. ........................................................ 220
Figure 8.13: Micrographs <strong>of</strong> foams obtained from each plate processed at sc CO 2 process condition T sat
45°C, P sat 100 bars, t sat 20 min and dP/dt 3bar/s. ............................................................ 221
Figure 8.14: Equivalent pore size and geometric porosity <strong>of</strong> foams at different places in <strong>the</strong> chamber. ...... 221
Figure 8.15: Foams <strong>of</strong> pellets prepared in one batch. .................................................................................... 222
Figure 8.16: Pore equivalent size and geometric porosity <strong>of</strong> composite foam in <strong>the</strong> same batch. ................ 223
Figure 8.17: Percentage <strong>of</strong> pores in composite foams in <strong>the</strong> same batch. ..................................................... 223
Figure 8.18: Surface area <strong>of</strong> pores in composite foams in <strong>the</strong> same batch. ................................................... 223
Figure 8.19: 90% PLGA 85:15 +5%ATCP (sr) +5%βTCP (sr) foams randomly selected from different batches
processed at - T sat 45°C, P sat 100 bar t sat 20 min and dual dP/dt 1 and 3bar/s. ............... 225
Figure 8.20: SEM micrographs <strong>of</strong> 90 % PLGA 85:15 + 5 % ATCP (sr) + 5 % βTCP (sr) foams sected from
different batches and processed at: T sat 48°C, P sat 100 bars, t sat 20 min and dual dP/dt 1
and 3bar/s ................................................................................................................................... 226
Figure 8.21: Equivalent pore size and geometric porosity <strong>of</strong> 90% PLGA 85:15 + 5% ATCP (sr) + 5% βTCP (sr)
foams from different batches. ..................................................................................................... 227
Figure 8.22: Pore frequency and cummulative total pore area as a function <strong>of</strong> average pore diameter for 90%
PLGA 85:15 +5%ATCP (sr) +5%βTCP (sr) foams selected randomly from different runs. ................ 227
Figure 8.23: Equivalent pore diameter vs pore numbers for selected ............................................................ 228
Figure 8.24: Pore diameter and porosity <strong>of</strong> composite foams from different batches ................................... 228
Figure 8.25: Pore morphology <strong>of</strong> selected polymer composite foams. ......................................................... 229
Figure 8.26: Internal morphology <strong>of</strong> 90% PLGA 85:15 +5%ATCP (sr) +5%βTCP (sr) foams ............................... 229
Figure 8.27: Some typical stress–strain curves <strong>of</strong> PLGA 85:15 porous scaffolds with internal macropores at
different porosities produced at different process conditions..................................................... 230
Figure 8.28: Compressive properties <strong>of</strong> pure PLGA 85:15 foams with different porosities. ............................ 231
Figure 8.29: Compressive properties <strong>of</strong> foams containing 90 % PLGA 85:15 + 5 % TCP (sr) + 5 % ATCP (sr)
processed at T sat 48°C, P sat 100 bars, t sat 20 min, dual and dP/dt 1 bar/s and 3 bar/s. ..... 231
Figure 8.30: Compressive properties <strong>of</strong> foams containing 90 % PLGA 85:15 + 5 % TCP (sr) + 5 % ATCP (sr)
obtained after co-grinding. ......................................................................................................... 232
Figure 8.31: Compressive properties <strong>of</strong> 90%PLGA 85:15 + 5%TCP (sr) +5%ATCP (sr) foams with different fillers
ratios ........................................................................................................................................... 233
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