Influence of the Processes Parameters on the Properties of The ...
Influence of the Processes Parameters on the Properties of The ...
Influence of the Processes Parameters on the Properties of The ...
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Chapter 5.<br />
Characterizati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> Scaffolds for C<strong>on</strong>nective Tissue Engineering<br />
diameters. Except for <str<strong>on</strong>g>the</str<strong>on</strong>g> experiment P9, all produced foams have porosity higher than 75%, <str<strong>on</strong>g>the</str<strong>on</strong>g> maximum<br />
being reached for c<strong>on</strong>diti<strong>on</strong>s P4 and P6. (cf. Figure 5.14).<br />
On <str<strong>on</strong>g>the</str<strong>on</strong>g> Table 5.16, A, B and C represent <str<strong>on</strong>g>the</str<strong>on</strong>g> positi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> polymer pellet in <str<strong>on</strong>g>the</str<strong>on</strong>g> chamber, top, centre<br />
and bottom positi<strong>on</strong> respectively (cf. Figure 4.12-a, Filling <str<strong>on</strong>g>the</str<strong>on</strong>g> chamber with Tefl<strong>on</strong>). <strong>The</strong> effects shown in<br />
Table 5.17 have global meanings in two ways. <strong>The</strong> effects <str<strong>on</strong>g>of</str<strong>on</strong>g> a level are calculated by taking <str<strong>on</strong>g>the</str<strong>on</strong>g> difference<br />
<str<strong>on</strong>g>of</str<strong>on</strong>g> pore diameter and <str<strong>on</strong>g>the</str<strong>on</strong>g> global average pore diameter <str<strong>on</strong>g>of</str<strong>on</strong>g> all experiments. Firstly, if <str<strong>on</strong>g>the</str<strong>on</strong>g> effect is negative<br />
(positive respectively), that means that this factor has a negative (positive) effect and resulting pore diameter<br />
will be smaller (bigger). Sec<strong>on</strong>d, <str<strong>on</strong>g>the</str<strong>on</strong>g> value is indicative <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>the</str<strong>on</strong>g> importance <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>the</str<strong>on</strong>g> effect.<br />
Table 5.16: Experiments with <str<strong>on</strong>g>the</str<strong>on</strong>g> Taguchi design and <str<strong>on</strong>g>the</str<strong>on</strong>g> average diameter <str<strong>on</strong>g>of</str<strong>on</strong>g> pores for PLGA 50:50 .<br />
Experiment T sat P sat t sat dP/dt Average Pore Diameter Average*<br />
Nr. (°C) (bar) (min) (bar/s) A B C (μm)<br />
P1 36.5 120 20 3 549.88 535.02 268.32* 542.45<br />
P2 36.5 150 45 5 9.66 12.54* 9.19 9.42<br />
P3 36.5 200 90 10 4.31 3.66* 4.29 4.30<br />
P4 45 120 45 10 18.82 152.68* 18.25 18.53<br />
P5 45 150 90 3 19.08 11.96* 21.66 20.37<br />
P6 45 200 20 5 9.98 13.19 7.62 10.26<br />
P7 60 120 90 5 127.83 87.50* 101.56 114.70<br />
P8 60 150 20 10 113.23 105.81 80.66* 109.52<br />
P9 60 200 45 3 10.72* 14.15 13.94 14.05<br />
* values eliminated in <str<strong>on</strong>g>the</str<strong>on</strong>g> calculati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>the</str<strong>on</strong>g> average because varying more than 10%<br />
Table 5.17: Average diameter <str<strong>on</strong>g>of</str<strong>on</strong>g> pores for all factors and <str<strong>on</strong>g>the</str<strong>on</strong>g>ir effects.<br />
Factor Variati<strong>on</strong>