Farshid Guilak, Ph.D. Professor - K-Lab - Duke University

NAME
Farshid Guilak, Ph.D.
BIOGRAPHICAL SKETCH
POSITION TITLE
Professor
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY
Rensselaer Polytechnic Institute, Troy NY B.S. 1985 Biomedical Engineering
Rensselaer Polytechnic Institute, Troy NY M.S. 1987 Biomedical Engineering
Columbia University, New York NY M.Phil. 1990 Mechanical Engineering
Columbia University, New York NY Ph.D. 1992 Mechanical Engineering
Professional Experience
1986-91 Frank E. Stinchfield Fellow in Orthopaedic Biomechanics, Columbia University, Advisor: Van C. Mow
1991-94 Assistant Professor of Orthopaedics, SUNY Stony Brook, Adjunct Asst. Prof. of Mechanical Engineering,
1994-00 Assistant Research Professor of Orthopaedic Surgery, Duke University Medical Center
1994- Assistant Professor of Biomedical Eng. and Mechanical Eng. & Materials Science, Duke University
1999- Director of Research, Division of Orthopaedic Surgery
2001- Associate Professor of Surgery (with tenure)
2002-4 Co-Director, Center for Biomolecular and Tissue Engineering, Duke University
2002- Editor-in-Chief, North America, Journal of Biomechanics
2004- Professor of Surgery and Biomedical Engineering, Duke University Medical Center
Related Professional Service
Editorial Consultant’s Panel, J Biomech, 1999-02; Editorial Board, OA & Cart, 2001-present; Editorial Board, E-
BIOMED, 2001-4; Editorial Board, DNA & Cell Biology, 2004-, Editorial Board, Current Rheumatology Reviews; Guest
Editor, J Biomech, Special Issue on “Cell Mechanics”, 1/00; Guest Editor, J Biomech Eng, Special Issue on “Cell and
Tissue Engineering”, 6/00; President, North Carolina Tissue Engineering Interest Group, 2002-3.
Ad Hoc Reviewer (selected)
NSF Bioengineering Division, 1993, 1998, 1999; The Whitaker Foundation, 1996, 1997; NIH Molecular Biology Study Section
ZRG2 MBY (1B), 1998; Arthritis Society of Canada, 1999; NSF POWRE Study Section, 1999; NIH Orthopaedics and
Musculoskeletal Study Section, 1999, 2001; NIH Tissue Engineering Study Section, 1999; Netherlands Organization for
Scientific Research, 2000; Hong Kong Science Association, 2000, 2001; NIH MSTP Site Visit Team, 2001; NSF ERC Site
Visit Team, 2001; NIH F10 Panel, 2002; OREF Review Panel, 2002-5, NIBIB T32 Panel, 2004-5, NIAMS SBIR Panel, 2003-5
Honors and Awards
Frank E. Stinchfield Fellowship in Orthopaedic Biomechanics, 1986-1991
Best Paper Award, American Society of Mechanical Engineers, Student Paper Competition, 1990
Young Investigator's Award, Orthopaedic Research Societies of USA, Japan, and Canada, 1991
Young Investigator's Award, World Congress on Medical Physics and Biomedical Engineering, 1991
New Investigator Recognition Award, Orthopaedic Research Society, 1994
Presidential Scholarship Award, Scanning Microscopy Society, 1997
FIRST Award, National Institutes of Health (NIAMS), 1997
George W. Thorn Award, The Whitaker Foundation, 1997
Invited Delegate, National Academy of Engineering meeting on “Frontiers of Engineering”, 1997
Kappa Delta Young Investigator Award, American Academy of Orthopaedic Surgeons, 1998
William Harris Award, Orthopaedic Research Society, 2000

Y.C. Fung Young Investigator Award, American Society of Mechanical Engineers, 2000
Richard Skalak Best Paper Award, American Society of Mechanical Engineers, 2004
Faculty of 1000, BiomedCentral, 2004
Books
Cell Mechanics and Cellular Engineering. Eds. V.C. Mow, F. Guilak, R. Tran-Son-Tay, and R.M. Hochmuth, Springer Verlag,
New York, 1994.
Functional Tissue Engineering. Eds: F. Guilak, D. Butler, D. Mooney, and S. Goldstein. Springer Verlag, NY, 2003.

Peer-Reviewed Journal Articles (selected from 99)
1. Erickson, G.R., Gimble, J.M., Franklin, D.M., Rice, H.E., Awad, H., and Guilak, F. (2002): Chondrogenic potential of
adipose tissue-derived stromal cells in vitro and in vivo. Biochem Biophys Res Comm, 290(2):763-769.
2. Guilak, F., Erickson, G.R., and Ting-Beall, H.P. (2002): The effects of osmotic stress on the viscoelastic and physical
properties of articular chondrocytes. Biophys J, 82(2):720 727.
3. Spurney, R.F., Flannery, P.J., Garner, S.C., Athirakul, K., Liu, S., Guilak, F., and Quarles, L.D. (2002): Anabolic
effects of a G-protein-coupled receptor kinase inhibitor expressed in osteoblasts. J Clin Inv, 109(10):1361-1371.
4. Guilak, F., Kapur, R., Sefton, M.V., Vandenburgh, H.H., Koretsky, A.P., Kriete, A., and O’Keefe, R. (2002):
Functional assessment of engineered tissues and elements of tissue design. Ann NY Acad Sci, 961:207-209.
5. Guilak, F. (2002): Functional tissue engineering: The role of biomechanics in reparative medicine. Ann NY Acad Sci,
961:193-195.
6. Alexopoulos, L.G., Haider, M.A., Vail, T.P, and Guilak, F. (2003): Alterations in the mechanical properties of the
human chondrocyte pericellular matrix with osteoarthritis. J Biomech Eng, 125(3):323-333.
7. Wickham, M.Q., Erickson, G.R., Gimble, J.M., Vail, T.P., and Guilak, F. (2003): Multipotent stromal cells derived
from the infrapatellar fat pad of the knee. Clin Orth Rel Res. Research, 412:196-212.
8. Awad, H.A., Halvorsen, Y.D.C., Gimble, J.M., and Guilak, F. (2003): Effects of TGF-β1 and dexamethasone on
growth and chondrogenic differentiation of adipose derived stromal cells in vitro. Tissue Eng, 9(6):1301-1312.
9. Gimble, J.M. and Guilak, F. (2003): Adipose derived adult stem cells: Isolation, characterization, and differentiation
potential. Cytotherapy, 5(5):362-9.
10. Gimble, J.M. and Guilak, F. (2003): Differentiation potential of adipose derived adult stem (ADAS) cells. Current
Topics in Developmental Biology, 58:137-60.
11. Awad, H.A., Wickham, M.Q., Leddy, H.A., Gimble, J.M., and Guilak, F. Chondrogenic differentiation of adiposederived
adult stem cells in agarose, alginate, and gelatin scaffolds. Biomaterials, 25(16):3211-3222.
12. Estes, B.T., Gimble, J.M., and Guilak, F. (2004): Mechanical signals as regulators of stem cell fate. Current Topics in
Developmental Biology, 60:91-126.
13. Guilak, F., Awad, H.A., Fermor, B., Leddy, H.A., and Gimble, J.M (2004): Adipose-derived adult stem cells
for cartilage tissue engineering. Biorheology, 41:389-399.
14. Leddy, H.A., Awad, H.A., and Guilak, F. (2004): Molecular diffusion in tissue-engineered cartilage
constructs: effects of time and culture conditions, Journal of Biomedical Materials Research, 70B(2):397-
406.
15. Wang, D.W., Fermor, B., Gimble, J.M., Awad, H.A., and Guilak, F. (2005): The influence of oxygen on the
proliferation and metabolism of adipose derived adult stem cells. Journal of Cell Physiology [Epub]
16. Tognana, E., Chen, F., Padera, R.F., Leddy, H.A., Christensen, S.E., Guilak, F., Vunjak-Novakovic, and
Freed, L.E. (2005): Adjacent tissues (cartilage, bone) affect the functional integration of engineered cartilage
in vitro. OA & Cartilage3(2):129-38.
17. Alexopoulos LG, Williams GM, Upton ML, Setton LA, Guilak F. (2005) Osteoarthritic changes in the
biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage.J Biomech.
38(3):509-17.
18. Betre, H., Ong, S.R., Guilak, F., Chilkoti, A., Fermor, B., and Setton, L.A. Elastin-like polypeptides
promote chondrocytic differentiation of human adipose derived adult stem cells in vitro. Biomaterials,
doi:10.1016/j.biomaterials.2005.05.071.
19. Guilak, F., Lott, K.E., Awad, H.A., Hicok, K., Fermor, B., and Gimble, J.M. Clonal analysis of the
differentiation potential of human adipose-derived adult stem cells. Journal of Cellular Physiology,
Published Online: 14 Jul 2005, DOI: 10.1002/jcp.20463.
20. Hewitt, J., Harrelson, J., Dailiana, Z., Guilak, F., and Fink, C. (2005): The effect of intermittent pneumatic
compression on fracture healing. Journal of Orthopaedic Trauma, 19(6):371-6..

21. Baaijens, F.T.P., Trickey, W.R., Laursen, T.A., and Guilak, F. Large deformation finite element analysis of
micropipette aspiration to determine the mechanical properties of the chondrocyte. Annals of Biomedical
Engineering, 33(4):494-501.
22. Magnussen, R., Guilak, F., and Vail, T.P. (2005): Cartilage degeneration in post-collapse cases of
osteonecrosis of the femoral head: Altered mechanical properties in tension, compression, and shear.
Journal of Orthopaedic Research, 23:576-583.
23. Magnussen, R., Guilak, F., and Vail, T.P. (2005): Articular cartilage degeneration in early post-collapse
cases of osteonecrosis of the femoral head. Journal of Bone and Joint Surgery (American), 87:1272-7.
24. Xiao, Z., Awad, H.A., Liu, S., Mahliios, J., Zhang, S., Guilak, F., Mayo, M.S., and Quarles, L.D. Selective
Runx2-II deficiency leads to low turnover osteopenia in adult mice. Developmental Biology, 283(2):345-56.

Ongoing Research Support (Current)
NIH (P01 AR50245) (Guilak, F.) 8/03-7/08
Biomechanics and inflammation in osteoarthritis
The goal of this Program Project Grant is to study is to determine the interactions of biomechanical factors and
inflammation on biomarkers of osteoarthritis in various model systems, ranging from tissue explants, to transgenic mice,
and to clinical studies of obesity and exercise.
NIH (T32 EB01630) (Guilak, F.) 1/04-12/08
Postdoctoral training in Biomolecular and Tissue Engineering
This represents an institutional training grant for post-doctoral training in the Center for Biomolecular and Tissue
Engineering.
NIH (R01 AG15768) (Guilak, F.) 1/98-12/07
Viscoelastic properties of normal and OA chondrons
The goal of this study is to determine the mechanical properties of the pericellular matrix of articular chondrocytes using
micropipette aspiration and microindentation techniques.
NIH (R01 AR48182) (Guilak, F.) 12/02-11/05
Biomechanical factors in rheumatoid arthritis.
The goal of this study is to examine the effects of cytokines on the mechanical properties of the chondron and the cartilage
extracellular matrix in articular cartilage from rheumatoid arthritis.
NIH (RO1 AR49790) (Fermor, B.) 6/01-5/04
Nitric Oxide, Oxygen and Mechanical Stress in Cartilag
The goal of this study is to examine the role of mechanical stress and oxygen in NO production in articular cartilage.
Department of Veteran’s Affairs (Weinberg, J.B.) 4/04-3/06
Mechanical stress, nitric oxide, and the meniscus
The goal of this study is to examine changes in gene expression for nitric oxide synthase and cyclooxygenase enzymes, and
their interactions, in the meniscus under conditions of static or dynamic stress.
NASA (Freed, L).(F. Guilak subcontract PI) 1/04-12/07
Microgravity tissue engineering
The goal of this study is to determine the role of nutrient diffusion in the formation of tissue engineered cartilage constructs
within a bioreactor.
Recently Completed Research
NIH (R21 AR49294) (Guilak, F.) 10/02-9/04
3D woven scaffolds for tissue engineering
The goal of this study was to develop bioartificial scaffolds with mechanical properties similar to those of cartilage.