Dr. Guilak's Biosketch - K-Lab - Duke University

Principal Investigator/Program Director (Last, First, Middle):
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Farshid Guilak, Ph.D.
eRA COMMONS USER NAME
guilak
POSITION TITLE
Laszlo Ormandy Professor
of Orthopaedic Surgery
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
FIELD OF STUDY
Rensselaer Polytechnic Institute, Troy NY B.S. 1985 Biomedical Engineering
Rensselaer Polytechnic Institute, Troy NY M.S. 1987 Biomedical Engineering
Columbia University, New York NY M.Phil. 1990 Mechanical Engineering
Columbia University, New York NY Ph.D. 1992 Mechanical Engineering
Professional Experience
1986-91 Frank E. Stinchfield Fellow in Orthopaedic Biomechanics, Columbia Univ., Advisor: Van C. Mow
1991-94 Assistant Professor of Orthopaedics, SUNY Stony Brook, Adjunct Asst. Prof. of Mech. Eng.
1994-00 Assistant Research Professor of Orthopaedic Surgery, Duke University Medical Center
1994- Assistant Professor of Biomedical Eng. and Mechanical Eng. & Materials Science, Duke Univ.
1999- Director of Research, Division of Orthopaedic Surgery
2001- Associate Professor of Surgery (with tenure)
2002-4 Co-Director, Center for Biomolecular and Tissue Engineering, Duke University
2002- Editor-in-Chief, North America, Journal of Biomechanics
2004- Professor of Surgery, Biomedical Engineering, and Mechanical Engineering & Materials Science,
Duke University Medical Center
2006- Laszlo Ormandy Professor of Orthopaedic Surgery
Honors and Awards (selected, past 5 years)
Best Paper Award, American Society of Mechanical Engineers, Student Paper Competition, 1990
Young Investigator's Award, Orthopaedic Research Societies of USA, Japan, and Canada, 1991
Young Investigator's Award, World Congress on Medical Physics and Biomedical Engineering, 1991
New Investigator Recognition Award, Orthopaedic Research Society, 1994
Presidential Scholarship Award, Scanning Microscopy Society, 1997
FIRST Award, National Institutes of Health (NIAMS), 1997
George W. Thorn Award, The Whitaker Foundation, 1997
Invited Delegate, National Academy of Engineering meeting on “Frontiers of Engineering”, 1997
Kappa Delta Young Investigator Award, American Academy of Orthopaedic Surgeons, 1998
William Harris Award, Orthopaedic Research Society, 2000
Y.C. Fung Young Investigator Award, American Society of Mechanical Engineers, 2000
Richard Skalak Best Paper Award, American Society of Mechanical Engineers, 2004
College of Fellows, American Institute for Medical and Biological Engineering, 2005
Marshall Urist Award for Excellent in Tissue Regeneration Research, Orthopaedic Research Society, 2006
Chancellor’s Distinguished Lecture and Medal, Louisiana State University, 2006
Duke Startup Challenge, 1 st place Overall, 1 st place Health & Life Sciences, 1 st Place Elevator Pitch, 2006
Outstanding Postdoctoral Mentor Award, Duke University, 2006
FDA Advisory Committee, on Cellular, Tissue, and Gene Therapies, 2006-9
Inaugural DukeMed Scholar, 2007
Top 10 Arthritis Advances of 2007, Arthritis Foundation, 2008
Best paper award, Bronze Medal, Army Science Conference, 2008
Fellow, American Society of Mechanical Engineers, 2008
PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page

Principal Investigator/Program Director (Last, First, Middle):
Books
Cell Mechanics and Cellular Engineering. Eds. V.C. Mow, F. Guilak, et al. Springer Verlag, New York, 1994.
Functional Tissue Engineering. Eds: F. Guilak, et al. Springer Verlag, NY, 2003.
Peer-Reviewed Journal Articles (past year, selected from >155)
1. Bunnell, B. A., Estes, B. T., Guilak, F., Gimble, J. M., 2008. Differentiation of adipose stem cells. Methods
Mol Biol 456, 155-71.
2. Chalut, K. J., Chen, S., Finan, J. D., Giacomelli, M. G., Guilak, F., Leong, K. W., Wax, A., 2008. Label-free,
high-throughput measurements of dynamic changes in cell nuclei using angle-resolved low coherence
interferometry. Biophys J 94, 4948-56.
3. Chang, D. P., Abu-Lail, N. I., Guilak, F., Jay, G. D., Zauscher, S., 2008. Conformational mechanics,
adsorption, and normal force interactions of lubricin and hyaluronic acid on model surfaces. Langmuir 24,
1183-93.
4. Cheng, N. C., Estes, B. T., Awad, H. A., Guilak, F., 2008. Chondrogenic Differentiation of Adipose-Derived
Adult Stem Cells by a Porous Scaffold Derived from Native Articular Cartilage Extracellular Matrix. Tissue
Eng Part A.
5. Coles, J. M., Blum, J. J., Jay, G. D., Darling, E. M., Guilak, F., Zauscher, S., 2008. In situ friction
measurement on murine cartilage by atomic force microscopy. J Biomech 41, 541-8.
6. Darling, E. M., Guilak, F., 2008. A neural network model for cell classification based on single-cell
biomechanical properties. Tissue Eng Part A 14, 1507-15.
7. Darling, E. M., Topel, M., Zauscher, S., Vail, T. P., Guilak, F., 2008. Viscoelastic properties of human
mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes. J Biomech 41,
454-64.
8. Davies, C. M., Guilak, F., Weinberg, J. B., Fermor, B., 2008. Reactive nitrogen and oxygen species in
interleukin-1-mediated DNA damage associated with osteoarthritis. Osteoarthritis Cartilage 16, 624-30.
9. Estes, B. T., Diekman, B. O., Guilak, F., 2008. Monolayer cell expansion conditions affect the chondrogenic
potential of adipose-derived stem cells. Biotechnol Bioeng 99, 986-95.
10. Finan, J. D., Chalut, K. J., Wax, A., Guilak, F., 2008. Nonlinear Osmotic Properties of the Cell Nucleus. Ann
Biomed Eng.
11. Griffin, T. M., Guilak, F., 2008. Why is obesity associated with osteoarthritis? Insights from mouse models
of obesity. Biorheology 45, 387-98.
12. Kim, E., Guilak, F., Haider, M. A., 2008. The dynamic mechanical environment of the chondrocyte: a
biphasic finite element model of cell-matrix interactions under cyclic compressive loading. J Biomech Eng
130, 061009.
13. Leddy, H. A., Christensen, S. E., Guilak, F., 2008. Microscale diffusion properties of the cartilage
pericellular matrix measured using 3D scanning microphotolysis. J Biomech Eng 130, 061002.
14. Leddy, H. A., Guilak, F., 2008. Site-specific effects of compression on macromolecular diffusion in articular
cartilage. Biophys J 95, 4890-5.
15. McNulty, A. L., Guilak, F., 2008. Integrative repair of the meniscus: lessons from in vitro studies.
Biorheology 45, 487-500.
16. McNulty, A. L., Weinberg, J. B., Guilak, F., 2008. Inhibition of Matrix Metalloproteinases Enhances In Vitro
Repair of the Meniscus. Clin Orthop Relat Res, epub, in press
17. Moutos, F. T., Guilak, F., 2008. Composite scaffolds for cartilage tissue engineering. Biorheology 45, 501-
12.
18. Pritchard, S., Votta, B. J., Kumar, S., Guilak, F., 2008. Interleukin-1 inhibits osmotically induced calcium
signaling and volume regulation in articular chondrocytes. Osteoarthritis Cartilage 16, 1466-73.
19. Seifer, D. R., Furman, B. D., Guilak, F., Olson, S. A., Brooks, S. C., 3rd, Kraus, V. B., 2008. Novel synovial
fluid recovery method allows for quantification of a marker of arthritis in mice. Osteoarthritis Cartilage 16,
1532-8.
20. Upton, M. L., Gilchrist, C. L., Guilak, F., Setton, L. A., 2008. Transfer of macroscale tissue strain to
microscale cell regions in the deformed meniscus. Biophys J 95, 2116-24.
21. Ward, B. D., Furman, B. D., Huebner, J. L., Kraus, V. B., Guilak, F., Olson, S. A., 2008. Absence of
posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse. Arthritis Rheum 58, 744-53.
22. Wilusz, R. E., Weinberg, J. B., Guilak, F., McNulty, A. L., 2008. Inhibition of integrative repair of the
meniscus following acute exposure to interleukin-1 in vitro. J Orthop Res 26, 504-12.
PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page