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Prof Chia Boon Lock receives the SMA Honorary ... - nuhcs

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MICA (P) 023/09/2007 Issue No. 11 • January – June 2008<br />

<strong>Prof</strong> <strong>Chia</strong> <strong>Boon</strong> <strong>Lock</strong> <strong>receives</strong> <strong>the</strong><br />

<strong>SMA</strong> <strong>Honorary</strong> Membership Award<br />

– READ MORE ABOUT IT ON PAGE 2


in this issue<br />

02<br />

04<br />

PROF CHIA BOON LOCK<br />

RECEIVED <strong>SMA</strong> HONORARY<br />

MEMBERSHIP AWARD<br />

UPCOMING PUBLIC SYMPOSIUM<br />

ON SUDDEN CARDIAC DEATH<br />

RECEIVING THE <strong>SMA</strong> HONORARY<br />

<strong>Prof</strong> <strong>Chia</strong> <strong>Boon</strong><br />

05<br />

06<br />

07<br />

08<br />

10<br />

MRCP (UK) PREPARATORY<br />

COURSE<br />

CAROTID ARTERY STENTING<br />

INFORMATION TECHNOLOGY @<br />

THE HEART INSTITUTE<br />

NHG HMDP EXPERT VISIT –<br />

A/PROF DAVID CAMPBELL<br />

1 ST SINGAPORE-ASIA CARDIAC<br />

RESYNCHRONISATION THERAPY<br />

COURSE<br />

CARDIAC REHABILITATION<br />

PROGRAMME<br />

16 TH ANNUAL CONGRESS OF THE<br />

ASIAN SOCIETY FOR<br />

CARDIOVASCULAR AND THORACIC<br />

SURGERY<br />

A/<strong>Prof</strong> Tan Huay Cheem, Chief, Cardiac<br />

11<br />

12<br />

13<br />

14<br />

16<br />

18<br />

20<br />

WET LAB WORKSHOP<br />

16 TH ASCVTS ENDOVASCULAR<br />

AORTIC STENTING COURSE<br />

SINGAPORE CARDIAC SOCIETY<br />

LECTURER AWARD<br />

FIRST PRIZE – YOUNG<br />

INVESTIGATOR’S AWARD<br />

CHICAGO ACC SUCCESS<br />

GIVING THE SICK HEART A BREAK<br />

NMRC GRANT AWARD<br />

COARCTATION STENTING –<br />

PERCUTANEOUS THERAPY FOR A<br />

RARE PROBLEM<br />

CIT BEIJING MEETING<br />

HAPPENINGS<br />

DIRECTORY AND AWARDS<br />

FEEDBACK<br />

Please direct your feedback to<br />

The Editor, PULSE<br />

c/o The Heart Institute<br />

National University Hospital<br />

Cardiac Department<br />

Level 3, Main Building<br />

Singapore 119074<br />

Tel 6772 5565<br />

Fax 6778 6057<br />

Email The_Heart_Institute@nuh.com.sg<br />

EDITOR<br />

Dr Poh Kian Keong<br />

ABSTRACTS, PUBLICATIONS AND<br />

NEW DOCTORS ON BOARD<br />

ADVISOR<br />

A/<strong>Prof</strong> Tan Huay Cheem<br />

Contents are not to be reproduced without <strong>the</strong><br />

permission of The Heart Institute<br />

“The name <strong>Prof</strong> <strong>Chia</strong> <strong>Boon</strong> <strong>Lock</strong>, immediately conjures up an image<br />

of a superb clinical cardiologist who can interpret any cardiac<br />

murmur accurately, a dedicated educator who enjoys imparting his<br />

knowledge to <strong>the</strong> medical students and <strong>the</strong> younger doctors, a clinical<br />

researcher devoted to <strong>the</strong> pursuit of <strong>the</strong> intricacies of <strong>the</strong><br />

electrocardiogram and above all, a fa<strong>the</strong>rly figure who is always<br />

willing to lend a hearing ear and who is also always unstinting<br />

with his advice.” This is <strong>the</strong> citation by Assoc <strong>Prof</strong> Tan Huay Cheem<br />

for <strong>Prof</strong>essor <strong>Chia</strong> <strong>Boon</strong> <strong>Lock</strong>, who was conferred honorary<br />

membership of <strong>the</strong> Singapore Medical Association for <strong>the</strong> Year 2008<br />

at <strong>the</strong> recent <strong>SMA</strong> Dinner.<br />

One of <strong>the</strong> early pioneers of cardiology in Singapore, <strong>Prof</strong><br />

<strong>Chia</strong> was in charge of cardiology in Medical Unit II (later known<br />

as <strong>the</strong> University Department of Medicine II) at SGH from 1975<br />

to 1985 and was also Head of this Department from 1981 to 1983.<br />

After moving over to NUH, he became Head of <strong>the</strong> hospital’s<br />

Division of Cardiology, Department of Medicine, from 1986 to<br />

1989 and Chief of <strong>the</strong> Cardiac Department from 1996 to 1999.<br />

Amongst his many achievements, he was one of <strong>the</strong> first two<br />

cardiologists to introduce echocardiography and <strong>the</strong> first to<br />

introduce ambulatory blood pressure monitoring in Singapore.<br />

<strong>Prof</strong> <strong>Chia</strong> is <strong>the</strong> current Chairman of <strong>the</strong> Ministry of Health<br />

Workgroup for <strong>the</strong> Clinical Practice Guidelines on Lipids and a<br />

Member of <strong>the</strong> Workgroup on Hypertension. He was formerly<br />

President of <strong>the</strong> Singapore Cardiac Society, Chairman of <strong>the</strong><br />

Chapter of Physicians, Academy of Medicine (now <strong>the</strong> College of<br />

Physicians, Singapore) and a Member of <strong>the</strong> 17 th and 18 th Council<br />

of <strong>the</strong> Singapore Medical Association.<br />

An outstanding and inspiring teacher who is a favourite of<br />

<strong>the</strong> NUS medical students and also registrars training in Cardiology,<br />

<strong>Prof</strong> <strong>Chia</strong> has contributed significantly to <strong>the</strong> training of generations<br />

of doctors and cardiologists in Singapore. For this and o<strong>the</strong>r<br />

contributions, <strong>the</strong> NUS conferred him <strong>the</strong> title of Emeritus <strong>Prof</strong>essor<br />

THI PULSE | 2


AWARD<br />

<strong>Lock</strong><br />

Dept<br />

@ NUH<br />

in 2006. O<strong>the</strong>r awards which he has received include <strong>the</strong> Lee<br />

Foundation-National Healthcare Group Lifetime Achievement Award<br />

and <strong>the</strong> Dato Paduka Mahkota Brunei.<br />

Remarkably, most of <strong>Prof</strong> <strong>Chia</strong>’s achievements have been<br />

attained despite a long battle with advanced nasopharyngeal<br />

carcinoma – initially with <strong>the</strong> treatment 24 years ago and<br />

subsequently with <strong>the</strong> late side-effects arising from <strong>the</strong> radio<strong>the</strong>rapy<br />

which he had received. This is truly a<br />

testimony of his great courage and his<br />

indomitable spirit.<br />

The award at <strong>the</strong> dinner was<br />

presented to <strong>Prof</strong> <strong>Chia</strong> by <strong>the</strong> Permanent<br />

Secretary of Health, Miss Yong Ying-I.<br />

THI PULSE | 3


UPCOMING SYMPOSIUM ON<br />

Sudden Cardiac Death<br />

Dr Abdul Razakjr Omar, Cardiac Dept @ NUH<br />

The Singapore Medical<br />

Association will be<br />

organising <strong>the</strong> 39 th <strong>SMA</strong><br />

Annual National Medical<br />

Convention on 5 th July<br />

2008 at <strong>the</strong> Raffles City<br />

Convention Centre. The<br />

Heart Institute, National<br />

Healthcare Group is privileged to co-host this year’s important<br />

national healthcare convention.<br />

The recent extensive and frequent media coverage of<br />

sudden death among our youth propelled <strong>the</strong> quest to educate our<br />

society about <strong>the</strong> issues related to sudden cardiac death. Therefore<br />

this year <strong>the</strong> <strong>the</strong>me for <strong>the</strong> medical convention is “Prevention of<br />

Sudden Cardiac Death: Perception and Reality”. We have <strong>the</strong><br />

pleasure of having <strong>the</strong> senior parliamentary secretary of health,<br />

Mr Hawazi Diapi to grace <strong>the</strong> occasion as our guest of honour.<br />

Despite a substantial reduction in age-adjusted rates of death<br />

from cardiovascular causes during <strong>the</strong> past 40 to 50 years,<br />

cardiovascular disease remains <strong>the</strong> single most common cause of<br />

natural death in developed nations. Sudden cardiac death (SCD) is<br />

estimated to account for approximately 50 percent of all deaths<br />

from cardiovascular causes. In US, it accounted for 20% of all deaths<br />

annually (>300,000 SCD), while in Europe ~100 SCD per 100<br />

000 and in our society ~ 1 per 1000 individuals.<br />

The majority of such sudden deaths are caused by acute<br />

ventricular tachyarrhythmias, often triggered by acute coronary<br />

events (coronary artery disease)<br />

Clinical trials have shown that antiarrhythmic- drug <strong>the</strong>rapy<br />

is not effective in reducing mortality among patients who are<br />

assumed to be at risk for such death, but recent randomized trials<br />

have demonstrated a survival benefit in high-risk patients of <strong>the</strong>rapy<br />

with an implantable cardioverter–defibrillator, compared to<br />

conventional drug <strong>the</strong>rapy.<br />

The Centers for Medicare and Medicaid Services estimate<br />

that as many as 500,000 Medicare beneficiaries might be eligible<br />

to receive a prophylactic ICD in <strong>the</strong> United States. Given <strong>the</strong><br />

substantial cost of <strong>the</strong> ICD, <strong>the</strong> economic effect of this strategy<br />

must be considered in future healthcare planning.<br />

The importance of educating all doctors on SCD should be<br />

recognized. The highlights of <strong>the</strong> Medical Convention will include<br />

a one-day medical symposium and workshop for healthcare<br />

professionals and public forum. The interesting program will be<br />

finalized by Dr Eric Hong & Dr Ong HY (Chairmans for Public<br />

Symposium) and Dr Seow SC (Scientific Chairman for Medical<br />

Symposium) focusing on prevention and latest management of SCD.<br />

MRCP (UK)<br />

Preparatory Course<br />

Dr Eric Hong, Cardiac Dept @ NUH<br />

The Final MMed (Int Med)/MRCP PACES Examination<br />

Preparatory Course was held from 14-19 April in various hospitals<br />

in Singapore under <strong>the</strong> auspices of <strong>the</strong> Division of Graduate Medical<br />

Studies, Yong Loo Lin School of Medicine. This was an intensive<br />

programme consisting of practice sessions in all stations of <strong>the</strong><br />

examination, culminating in a full<br />

mock examination on <strong>the</strong> last<br />

2 days of <strong>the</strong> course.<br />

The Heart Institute is<br />

proud to organize <strong>the</strong><br />

examination held in <strong>the</strong><br />

National University Hospital.<br />

This demonstrates <strong>the</strong><br />

department’s strong<br />

commitment in training<br />

new generation of young<br />

medical specialists.<br />

The examination<br />

was well received by <strong>the</strong><br />

participants. Many found<br />

<strong>the</strong> cases useful in honing<br />

<strong>the</strong>ir clinical skills assisted by tutors at hand who critique <strong>the</strong><br />

participants’ examination and presentation skills.<br />

THI PULSE | 4


Carotid Artery Stenting<br />

Dr Teo Swee Guan, Cardiac Dept @ NUH<br />

Percutaneous transluminal angioplasty and stenting have become<br />

an established <strong>the</strong>rapeutic modality for coronary and peripheral<br />

arterial diseases, complementing surgical treatment. The<br />

application of this technique in carotid artery stenosis is an<br />

expected progression. The perceived advantages of carotid artery<br />

stenting (CAS) compared to carotid endarterectomy (CEA)<br />

include avoidance of general anes<strong>the</strong>sia and open surgical incision,<br />

shorter procedural time and hospitalization, and increased<br />

patients’ acceptance.<br />

Since FDA approval of CAS in 2004, it has been increasingly<br />

used for patients considered as high risk for surgery. In contrast to<br />

most endovascular peripheral arterial interventions, CAS<br />

represents a more challenging procedure because it requires <strong>the</strong><br />

use of smaller guidewire system (0.014-in vs 0.035-in guidewire<br />

system as in peripheral intervention), distal embolic protection<br />

device and rapid exchange system (vs. over-<strong>the</strong>-wire system). The<br />

use of long guiding sheath via common femoral artery to perform<br />

balloon angioplasty and stenting also represents new challenge for<br />

physicians with less CAS experience.<br />

CEA has long been <strong>the</strong> gold standard for <strong>the</strong> treatment of<br />

carotid artery stenosis. In North American Symptomatic Carotid<br />

Endarterectomy Trial (NASCET), symptomatic patients with<br />

carotid artery stenosis (70-99%) in CEA arm compared to medical<br />

group had higher perioperative stroke/death (5.8% vs 3.3%) but<br />

significantly lower major/fatal ipsilateral stroke at 2 years (2.5%<br />

vs 13.1%, p


SPOTLIGHT<br />

Information Technology<br />

@ The Heart Institute<br />

Dr James Yip & Ms Fauziah Azizi, Cardiac Dept @ NUH<br />

Within <strong>the</strong> ‘heart’ of operations at <strong>the</strong> The Heart Institute runs a<br />

unique software that has been storing critical information of our<br />

patients since 1991. This database, <strong>the</strong> cardiology information<br />

system (CIS) was initially spawned by <strong>Prof</strong>essor Maurice Choo,<br />

when he was <strong>the</strong>n chief of <strong>the</strong> cardiac department in NUH. It was<br />

initially a report generator for our echocardiography, treadmill<br />

and ambulatory blood pressure investigations and networked on a<br />

series of Macintosh computers. In 1998, <strong>the</strong> system was revamped<br />

to include research data and a new engine which helped<br />

cardiologists track <strong>the</strong>ir cases. In 2000, <strong>the</strong> system was moved to a<br />

Windows platform and <strong>the</strong> system was exported to Alexandra<br />

Hospital for use. It also boasted of a hospital interface which allowed<br />

its reports to be seen in NUH’s Hospital information system. We<br />

also developed an expert system for our percutaneous interventions<br />

which allowed full text reports to be generated from data captured<br />

during a procedure. We expanded our repertoire of investigations<br />

in <strong>the</strong> system to include 35 unique cardiology investigations ranging<br />

from Nuclear, CT angiography, Cardio-pulmonary exercise,<br />

Electrophysiology, congenital heart and vascular interventions.<br />

In 2001, we bravely entered <strong>the</strong> world of real time digital<br />

imaging. We began storing all images from echocardiography,<br />

cardiac ca<strong>the</strong>terization, electrocardiograms and nuclear. One of<br />

our overriding principles, was that all ‘raw’ source data from any<br />

system had to be stored and shared with everyone. In 2003, this<br />

database was installed in Tan Tock Seng Hospital and a National<br />

Heathcare Group (NHG) cardiology network was established. Our<br />

cardiology reports became available to <strong>the</strong> whole cluster in 2005<br />

on <strong>the</strong> computerized patient record system (CPRS). In 2003, we<br />

won a grant from The Enterprise Challenge from <strong>the</strong> Prime<br />

Minister’s office and we became <strong>the</strong> first medical unit in Singapore<br />

to use tablet personal computers for our daily ward rounds. This<br />

allowed all cardiology reports and images to be disseminated to<br />

<strong>the</strong> patients bedside. This improved our overall efficiency and<br />

allowed patients to have a shorter length of stay for our inpatients.<br />

In 2004, our CIS won <strong>the</strong> prestigious National Infocomm Awards<br />

from <strong>the</strong> Infocomm Development Authority (IDA) for <strong>the</strong> best<br />

implementation of IT in a public institution. In 2005, our IT<br />

director, Dr James Yip was inducted into <strong>the</strong> IT Hall of Fame of<br />

<strong>the</strong> Singapore Computing Society for <strong>the</strong> Friend of IT award.<br />

On a daily basis, <strong>the</strong> CIS allows our cardiologists to review<br />

patient information on a timely basis and to complete <strong>the</strong>ir<br />

cardiology reports. It has <strong>the</strong> capacity, for our doctors to work<br />

from home and to store interesting cases for teaching and research.<br />

The CIS contains coded fields which allows directed research to<br />

be conducted by our cardiologists and data to be collected<br />

prospectively. Thanks to this database, our research output each<br />

year grows by leaps and bounds, and doctors are able to submit<br />

numerous abstracts for local and overseas meetings, with some<br />

our young researchers frequently clinching young investigator<br />

awards. Part of <strong>the</strong> success of our CIS system, is that it is self<br />

developed and self managed. It is an organism which continually<br />

evolves to meet <strong>the</strong> new challenges, which is what expensive<br />

proprietary systems cannot promise to deliver. In <strong>the</strong> future<br />

development of <strong>the</strong> CIS, we hope to increase its connectivity<br />

to o<strong>the</strong>r systems and to deliver clinical decision support for<br />

<strong>the</strong> cardiologists.<br />

THI PULSE | 6


NHG HMDP EXPERT VISIT 26-20 MAY 2008<br />

A/<strong>Prof</strong> David Campbell<br />

A/<strong>Prof</strong> Peter Robless & Dr Benjamin Chua, CTVS @ NUH<br />

The Department of Cardiac, Thoracic & Vascular Surgery at NUH<br />

was honoured to host <strong>Prof</strong> David Campbell from Beth Israel<br />

Deaconess Hospital and Harvard Medical School, Boston, USA<br />

during his visit as NHG HMDP Expert in Vascular Surgery. <strong>Prof</strong><br />

Campbell is one of <strong>the</strong> most well-known figures in <strong>the</strong> field of limb<br />

salvage bypass surgery for peripheral vascular disease and diabetic<br />

foot preservation. His group in Boston have published extensively<br />

on limb salvage surgical techniques and outcomes for <strong>the</strong> last 20<br />

years and <strong>the</strong>ir results for limb salvage and low perioperative<br />

mortality are <strong>the</strong> gold standards o<strong>the</strong>rs aim for.<br />

<strong>Prof</strong> Campbell’s visit included a mix of lectures and<br />

demonstration surgery, in addition to a vascular anastomosis<br />

masterclass. In his series of lectures, he shared with an extensive<br />

audience of surgeons, physicians and anaes<strong>the</strong>tists, <strong>the</strong> experience<br />

and outcomes from his surgical series numbering more than 6000<br />

lower limb bypass surgeries.<br />

<strong>Prof</strong> Campbell has been instrumental in developing diabetic<br />

limb salvage programmes in <strong>the</strong> Vietnam and India in <strong>the</strong> last<br />

decade. He has been traveling to hospitals in Hanoi, Danang and<br />

Ho Chi Minh City for <strong>the</strong> last ten years to promote limb salvage<br />

and has reported this in <strong>the</strong> Bulletin of <strong>the</strong> American College of<br />

Surgeons. It was during one of <strong>the</strong>se trips that he met <strong>Prof</strong> KO<br />

Lee from <strong>the</strong> Dept of Endocrinology at NUH and was invited to<br />

visit Singapore to promote diabetic limb salvage.<br />

He was welcomed at NUH by <strong>the</strong> vascular surgery,<br />

endocrine, renal and diabetic foot teams. <strong>Prof</strong> Campbell assisted<br />

in two patients undergoing carotid endarterectomies. He also<br />

visited <strong>the</strong> vascular surgery units at Singapore General Hospital<br />

and Tan Tock Seng Hospital, where he participated in <strong>the</strong> vascular<br />

radiology meetings. At TTSH, he demonstrated his techniques of<br />

distal bypass surgery. Despite his busy schedule, <strong>Prof</strong> Campbell<br />

also found time to conduct a masterclass on vascular anastomotic<br />

techniques using animal cadaveric vessels models held in <strong>the</strong><br />

SmartLab of <strong>the</strong> Advanced Surgery Training Centre at NUH.<br />

Supported by Ethicon, J&J and Terumo Vascutek, it was well<br />

attended by an enthusiastic group of 10 surgeons and advanced<br />

surgery trainees. <strong>Prof</strong> Campbell remarked that, “This is <strong>the</strong> most<br />

number of surgeons I have trained in one afternoon ever!” Valuable<br />

lessons in surgical technique and a great time by all. He was also<br />

<strong>the</strong> guest of honour at a dinner hosted by <strong>the</strong> Vascular Surgical<br />

Society of Singapore held at <strong>the</strong> Peranakan restaurant,True Blue<br />

in Armenien Street. This was indeed a novel culinary experience<br />

for our visiting New England surgeon.<br />

<strong>Prof</strong> Campbell delivered his talk on “Infection,<br />

Neuropathy and Arterial Insufficiency in <strong>the</strong> Diabetic” at <strong>the</strong> NUH<br />

hospital grand rounds. After that he participated in <strong>the</strong> Diabetic<br />

Foot Ward Rounds conducted by <strong>Prof</strong> Aziz Na<strong>the</strong>r and <strong>the</strong> NUH<br />

diabetic foot team, where he shared his knowledge and experience<br />

in management in diabetic patients with foot wounds. This ward<br />

round was well-received and attended by a large group of surgeons,<br />

nurses and podiatrist.<br />

<strong>Prof</strong> Campbell’s visit as HMDP Expert was a resounding<br />

success, judging from <strong>the</strong> number of people who attended his<br />

lectures, ward rounds and masterclass. It was our pleasure to host<br />

his visit and we certainly hope that he too had a great time and will<br />

visit us again soon.<br />

THI PULSE | 7


don’t bypass Cardiac Rehabilitation<br />

Dr Eric Hong, Cardiac Dept @ NUH<br />

Cardiac rehabilitation is increasingly<br />

recognised as an integral component of<br />

<strong>the</strong> continuum of care for patients with<br />

cardiovascular disease. Its application is a<br />

class I recommendation in most<br />

contemporary cardiovascular clinical<br />

practice guidelines. Despite <strong>the</strong><br />

documentation of substantial morbidity<br />

and mortality benefits, cardiac<br />

rehabilitation services are vastly underutilised.<br />

Established in <strong>the</strong> late 1990s, <strong>the</strong> Cardiac<br />

Rehabilitation Programme (CRP) at National University<br />

Hospital (NUH) is characterized with a provisional<br />

comprehensive long term services involving medical evaluation,<br />

prescriptive exercise; cardiac risk factor modification, education,<br />

counseling and behavioural interventions.<br />

It is paramount that a good CRP is multifaceted and<br />

multidisciplinary in nature consisting doctors, specialized cardiac<br />

nurses, physio<strong>the</strong>rapists, dietitians, pharmacists, medical social<br />

workers, occupational <strong>the</strong>rapists, psychologist and psychiatrist. In<br />

NUH, cardiologist Dr. Eric Hong Cho Tek leads this unique<br />

specialised individualised programme. Dr Roger Ho, a psychiatrist,<br />

is also part of this dynamic<br />

multidisciplinary team.<br />

Upon <strong>the</strong> completion of <strong>the</strong><br />

National University Heart Centre for<br />

Cardiovascular Services, a dedicated<br />

cardiac rehabilitation gym with <strong>the</strong><br />

state-of-<strong>the</strong>-art exercise equipment<br />

and facilities will help to meet <strong>the</strong><br />

needs of <strong>the</strong> evolving society.<br />

Numerous studies have demonstrated that cardiac<br />

rehabilitation programmes can reduce <strong>the</strong> cardiac death rate by as<br />

much as 20 to 25 per cent. It has been shown to be as important as<br />

compliance to prescribed medication and following, of a strict<br />

recommended diet. Despite <strong>the</strong> presence of cardiac rehabilitation,<br />

only 15 to 20 per cent of appropriate candidates participated in a<br />

formal CRP in Singapore. In our survey, most quoted ignorance<br />

of <strong>the</strong> existence of a CRP.<br />

In NUH CRP, our goals are manifolds. Besides reducing<br />

morbidity and mortality, improvement of <strong>the</strong> quality of life,<br />

reduction in subsequent rehospitalization, and getting patient<br />

back to normality, if not better. We provide supervised exercise<br />

training, multidisciplinary education programme to patients<br />

1 st Singapore-Asia Cardiac Resynchronisation<br />

Dr Seow Swee Chong & Dr Abdul Razakjr Omar, Cardiac Dept @ NUH<br />

Heart failure is a major public health issue in developed countries,<br />

exacting a heavy toll on medical resources and more importantly,<br />

a high mortality and morbidity on <strong>the</strong> patients. Until recently, little<br />

o<strong>the</strong>r than medication could be done for patients with chronic heart<br />

failure who are not suitable for coronary revascularization or cardiac<br />

transplant. Patients were forced to restrict <strong>the</strong>ir activities often to<br />

minimally functional levels to adapt to <strong>the</strong>ir poor heart function<br />

while <strong>the</strong>y lived <strong>the</strong>ir lives under <strong>the</strong> spectre of certain death by<br />

progressive heart failure or sudden cardiac arrest.<br />

The advent of device <strong>the</strong>rapy for chronic heart failure has<br />

literally brought new life and hope for <strong>the</strong>se patients. Individuals<br />

with very poor heart function often have uncoordinated contraction<br />

of <strong>the</strong>ir heart walls. By implanting a pacemaker with multiple leads,<br />

<strong>the</strong>se walls can be made to move toge<strong>the</strong>r again in a coordinated,<br />

synchronized fashion resulting in improved symptoms, cardiac<br />

output and even a reduction in mortality. Aptly termed “cardiac<br />

resynchronization <strong>the</strong>rapy” (CRT), this modality has been shown<br />

in large clinical trials to reverse <strong>the</strong> process of progressive heart<br />

enlargement seen in chronic heart failure.<br />

Heart failure patients are also at high risk of sudden cardiac<br />

arrest due to life-threatening heart rhythm abnormalities. By<br />

combining a CRT pacemaker with a defibrillator in a single device,<br />

this o<strong>the</strong>r major cause of death in heart failure is addressed, and<br />

results in a fur<strong>the</strong>r reduction in mortality in <strong>the</strong> COMPANION<br />

and MIRACLE-ICD trials.<br />

THI PULSE | 8


Programme<br />

recovering from cardiac events such as a heart attack,<br />

interventional procedures like angioplasty, heart surgery (bypass,<br />

transplant or valvular) and congestive heart failure. This is to<br />

target <strong>the</strong> motivated individuals who want to reduce traditional<br />

cardiovascular risk factors. In NUH, we have also developed a<br />

dedicated smoking cessation programme<br />

In our experience, we are aware that many cardiac<br />

patients have high levels of stress and anxiety. Depression is<br />

prevalent after acute cardiac events, with 20 to 45 per cent<br />

of patients having significant depression after acute myocardial<br />

infarction (AMI). Depression is an independent risk factor<br />

for mortality in patients with AMI, or unstable angina. Several<br />

studies suggest improvement with cardiac rehabilitation<br />

intervention. Patients with depressive symptoms have a fivefold<br />

increased risk of non-completion of cardiac rehabilitation<br />

and <strong>the</strong>refore require enhanced attention and support. We<br />

have also dedicated a team to focus on neuropsychological<br />

aspect of <strong>the</strong>se patients.<br />

A review of 46 randomised trials of secondary<br />

prevention, in 18821 patients with coronary heart disease was<br />

recently conducted by <strong>the</strong> agency for Health care research and<br />

quality: Secondary prevention programs were demonstrated to<br />

reduce hospitalization, recurrent MI and long term mortality.<br />

Physicians can initiate <strong>the</strong> referral if <strong>the</strong>ir patient is appropriate<br />

for CRP in NUH.<br />

Please visit www.nuh.com.sg/_cardiac/<br />

ourServices_cardiacRehabilitation.htm or contact<br />

<strong>the</strong> CRP nurses for more information.<br />

Lai Shuet Ming – 67725563 / 95402582<br />

Rachel Chan Wang Hia – 67722436 / 95669078<br />

Ooi Lean See – 67722497 / 98028205<br />

(CRT) Therapy Course<br />

It is little wonder <strong>the</strong>refore that <strong>the</strong>re is much interest<br />

worldwide in <strong>the</strong> technique of performing CRT implants, which<br />

is more complex than a routine pacemaker implant. With <strong>the</strong><br />

generous support of St Jude Medical, <strong>the</strong> Cardiac Department at<br />

<strong>the</strong> National University Hospital was able to conduct <strong>the</strong> 1 st<br />

Singapore-Asia CRT implant course, which hosted foreign doctors<br />

from South Korea and <strong>the</strong> Philippines. Over <strong>the</strong> course of 3 days<br />

from 28 th till 30 th April 2008, live cases of CRT implant were<br />

performed, spaced apart by didactic lectures on <strong>the</strong> indications<br />

and trial evidence for such <strong>the</strong>rapy as well as methods for<br />

optimization of CRT devices post-implant. Led by course directors<br />

Dr Abdul Razakjr Omar and Dr Seow Swee Chong, <strong>the</strong> programme<br />

also included a practical session demonstrating optimization of <strong>the</strong><br />

devices using echocardiography.<br />

With overwhelmingly positive feedback from course<br />

participants, <strong>the</strong> Department is geared up to continue conducting<br />

such courses on a regular basis; sharing knowledge and<br />

experiences and fostering friendships with fellow cardiologists<br />

across <strong>the</strong> region.<br />

THI PULSE | 9


16 th Annual Congress of <strong>the</strong> Asian Society<br />

for Cardiovascular and Thoracic Surgery<br />

<strong>Prof</strong> Uwe Klima, CTVS @ NUH<br />

Singapore hosted <strong>the</strong> 16 th Annual Congress<br />

of <strong>the</strong> Asian Society for Cardiovascular and<br />

Thoracic Surgery (ASCVTS) held over 13–<br />

16 March 2008 under <strong>the</strong> Chairmanship of<br />

<strong>Prof</strong>essor Lee Chuen-Neng, Chair, University<br />

Surgical Cluster, Head, Department of<br />

Surgery and Department of Cardiac, Thoracic<br />

& Vascular Surgery, National University<br />

Health System. It was attended by over 870 participants from 50<br />

countries.<br />

Since its foundation in 1993, <strong>the</strong> ASCVTS had become<br />

<strong>the</strong> largest cardiothoracic Society In Asia. Its goals have been to<br />

promote <strong>the</strong> study of <strong>the</strong> art, science and practice of cardiovascular<br />

surgery, hence facilitating <strong>the</strong> exchange of ideas in <strong>the</strong> field of<br />

cardiovascular surgery. Journeying into <strong>the</strong> 21 st century,<br />

advancements in <strong>the</strong> field of healthcare have been accompanied<br />

by unexpected challenges and greater responsibilities. The <strong>the</strong>me<br />

this year – “Putting Patients first in <strong>the</strong> Era of Modern Technology”,<br />

embodies <strong>the</strong> purpose of this congress, which is to equip healthcare<br />

personnel as well as patients with medical knowledge that is<br />

becoming increasingly relevant in our society.<br />

wet lab workshop<br />

For <strong>the</strong> first time outside of America, <strong>the</strong> American<br />

Association for Thoracic Surgery (AATS) held a post-graduate<br />

review course. This was well received.<br />

The congress received over 250 free paper submission, of<br />

which 50% were for oral presentation over 14 sessions and 50%<br />

were for poster presentation. Alongside <strong>the</strong> main congress, several<br />

workshops namely <strong>the</strong> Haemodynamic Workshop, Endovascular<br />

Aortic Stenting Course and Minimally Invasive Thoracic<br />

Symposium were conducted at <strong>the</strong> Advanced Surgery Training<br />

Centre, National University Hospital. All <strong>the</strong> workshops were<br />

convened by our doctors with international and regional panelists.<br />

The nursing symposium which was attended by more than<br />

200 participants was coordinated by a nursing committee<br />

represented by all <strong>the</strong> major hospitals in Singapore.<br />

<strong>Prof</strong> Uwe Klima, CTVS @ NUH<br />

In conjunction with ASCVTS 2008, St. Jude Medical took <strong>the</strong><br />

opportunity to run a wet lab workshop on <strong>the</strong> 12 th March 2008.<br />

A total of 11 doctors, coming from various Asia countries<br />

participated in <strong>the</strong> workshop which was held at <strong>the</strong> Advanced<br />

Surgical centre at <strong>the</strong> National University Hospital of Singapore.<br />

The workshop was conducted by <strong>Prof</strong> Uwe Klima and A/<strong>Prof</strong><br />

Theodoros Kofidis from <strong>the</strong> National University Hospital and Dr<br />

Chua Yeow Leng from <strong>the</strong> National Heart Center.<br />

The workshop started with Dr Chua sharing a presentation on<br />

HIFU (High Intensity Focus Ultrasound) technology for open cardiac<br />

ablation for <strong>the</strong> treatment of Atrial Fibrillation. He shared <strong>the</strong><br />

differences between HIFU and o<strong>the</strong>r technologies, as well as <strong>the</strong><br />

method of performing a procedure using <strong>the</strong> EPICOR machine. The<br />

main advantage for HIFU is <strong>the</strong> ability to provide<br />

transmural ablation effectively and safely.<br />

There was also a short hands-on session<br />

where Dr Chua demonstrated an ablation<br />

using EPICOR on a porcine heart.<br />

This was followed by <strong>Prof</strong> Klima giving a presentation on<br />

<strong>the</strong> treatment of Valvular Disease using MHV (Mechanical Heart<br />

Valves). Regent TM valve was highlighted as one of <strong>the</strong> best performing<br />

MHV with outstanding performance for EOAI (Effective Orific Area<br />

Index) and profile. A/<strong>Prof</strong> Kofidis spoke on Current Trend for Tissue<br />

Heart Valves, <strong>the</strong> Epic TM Heart Valves was featured for its superb<br />

profile and unique anticalcification technology. The participants<br />

broke out into smaller groups where <strong>the</strong> trainers gave a detailed<br />

demonstration on <strong>the</strong> tips and tricks of sewing <strong>the</strong> Regent TM valve<br />

and Epic TM Supra valve onto a porcine heart. Each participant also<br />

had a chance to assist or replace a valve onto a porcine heart under<br />

<strong>the</strong> supervision of <strong>the</strong> trainers.<br />

Overall, <strong>the</strong> feedback and response towards <strong>the</strong> workshop<br />

have been positive. All participants mentioned that <strong>the</strong>y found <strong>the</strong><br />

session insightful, and <strong>the</strong> various advice given by <strong>the</strong> trainers during<br />

<strong>the</strong> session were invaluable in helping <strong>the</strong>m provide better patient<br />

care through better techniques and skills learn through <strong>the</strong> workshop.<br />

THI PULSE | 10


16 th ASCVTS Endovascular<br />

Aortic Stenting Course<br />

A/<strong>Prof</strong> Peter Robless, CTVS @ NUH<br />

The 16 th Annual<br />

Meeting of <strong>the</strong><br />

Asian Society for<br />

CardioVascular &<br />

Thoracic Surgery<br />

was held from <strong>the</strong><br />

12–16 th March<br />

2008 in Singapore.<br />

As part of <strong>the</strong><br />

meeting, <strong>the</strong> Heart<br />

Institute was pleased<br />

to host <strong>the</strong> ASCVTS Endovascular Aortic Stenting Course held at<br />

<strong>the</strong> Tan Sri Khoo Teck Puat Advanced Surgery Training Centre at<br />

<strong>the</strong> National University Hospital on <strong>the</strong> 15 th March 2008. The<br />

workshop was fully subscribed with over 60 delegates from<br />

Singapore, Indonesia, Phillipines, India, Taiwan, Thailand, Malaysia<br />

and Japan attending.<br />

We were pleased to bring toge<strong>the</strong>r an international faculty<br />

of eminent cardiovascular surgeons and interventionists involved<br />

in <strong>the</strong> training and development of thoracic endovascular aortic<br />

stenting programs. The guest faculty included Drs Roy Greenberg,<br />

Joe Bavaria, John Wolfe, Wei Zhou, Bart Muhs, Hassan Tehrani,<br />

Stephen Cheng, Ian Nixon, Shih Chun Che and Sophia Ang.<br />

This workshop aimed to address <strong>the</strong> practical aspects of patient<br />

selection, planning, case preparation and stent deployment. The<br />

current evidence base for thoracic aortic endovascular stenting was<br />

also presented and discussed.<br />

The participants were able to have a practical hands on<br />

demonstration of <strong>the</strong> leading thoracic aortic stentgrafts in clinical<br />

use such as <strong>the</strong> Gore TAG, Medtronic Valiant, COOK TX2 and<br />

Djumbodis Saint Come Chirurgie. There was intense interaction<br />

with experienced physician proctors and technical product specialists<br />

from <strong>the</strong> manufacturers.<br />

In addition to didactic presentations and small group handson<br />

demonstration <strong>the</strong>re was also interactive case discussions. In<br />

order to promote participation and discussion, several of <strong>the</strong> faculty<br />

brought <strong>the</strong>ir own teaching cases which were prepared on our 3-D<br />

Dextrobeam workstation for planning and discussion. This was<br />

facilitated by Dr Luis Serra and <strong>the</strong> team from Volume Interactions.<br />

This unique combination allowed <strong>the</strong> audience to view cases in <strong>the</strong><br />

standard axial, coronal and sagitall planes as well as in 3-D to fully<br />

appreciate <strong>the</strong> tortousity, landing zones, branching and access issues<br />

in thoracic endografting. Several cases involving thoracic aortic<br />

aneurysms, dissection and traumatic transections were discussed.<br />

Endovascular strategies involving hybrid repair of <strong>the</strong> thoracic aorta<br />

were also presented.<br />

THI PULSE | 11


Singapore Cardiac Society lecturer award<br />

Associate <strong>Prof</strong>essor<br />

Tan Huay Cheem is<br />

honoured as <strong>the</strong><br />

Singapore Cardiac<br />

Society Lecturer for<br />

Year 2008 at its<br />

recently held Annual<br />

Scientific Meeting<br />

(ASM). This is an<br />

award bestowed upon member who has contributed significantly<br />

to <strong>the</strong> Society. A/<strong>Prof</strong> Tan has served in <strong>the</strong> Council of <strong>the</strong> Society<br />

for <strong>the</strong> last 9 years since 1999, and was <strong>the</strong> Secretary, Vice<br />

President and eventually President of <strong>the</strong> Society for two terms<br />

from 2003–2005. He has contributed actively to many of <strong>the</strong><br />

Society’s continuing educational activities including helping to<br />

organize <strong>the</strong> 13 th SCS Annual ASM in Year 2000 and many<br />

international meetings such as <strong>the</strong> 13th ASEAN Congress of<br />

Cardiology in Year 2000 and 14 th Asian-Pacific Society of<br />

Cardiology in Year 2003. Cited by Dr Richard Ng, President of<br />

<strong>the</strong> SCS, A/<strong>Prof</strong> Tan is described as a dynamic and winsome doctor<br />

who is popular with both patients and colleagues locally and abroad<br />

for his enthusiastic and invaluable collaboration and fellowship. In<br />

his lecture, A/<strong>Prof</strong> Tan gave his insights on <strong>the</strong> “Management of<br />

Coronary Artery Disease-Diagnostic and Therapeutic Advances” which<br />

was warmly received by <strong>the</strong> audience.<br />

FIRST PRIZE<br />

Young Investigator’s Award<br />

Dr Chan Wan Xian, Cardiac Dept @ NUH<br />

It started with our department’s research grand round. After<br />

presenting my project entitled “Cardiorespiratory Gas Exchange<br />

Analysis During Dynamic Exercise Predicts Surgical Indications<br />

for Severe Mitral Regurgitation”, fellow colleagues encouraged<br />

<strong>the</strong> submission to <strong>the</strong> annual Singapore Cardiac Society meeting.<br />

I started working with my mentor, <strong>Prof</strong> Ling LH, to beat <strong>the</strong><br />

dateline of submission. We went through our data and statistics<br />

many times to draw accurate conclusions from months of hard<br />

work of patient recruitment and data collection. We <strong>the</strong>n<br />

proceeded with <strong>the</strong> drafting of our abstract and finally submitting<br />

just before <strong>the</strong> deadline.<br />

After weeks of waiting, I received an e-mail from <strong>the</strong><br />

Singapore Cardiac Society notifying us that <strong>the</strong> abstract has been<br />

selected for presentation at <strong>the</strong> Young Investigators’ Award session<br />

at <strong>the</strong> annual Singapore Cardiac Society Meeting. I immediately<br />

started preparing for <strong>the</strong> presentation.<br />

Our post-graduate education director, Dr Poh KK, arranged<br />

a practice session for us to present our studies to <strong>the</strong> department<br />

before <strong>the</strong> actual presentation. I was not fluent in my presentation.<br />

Fortunately, many colleagues from <strong>the</strong> department gave valuable<br />

comments from presentation style to slides content. That provided<br />

me feedback to reflect and improve.<br />

After that were<br />

sleepless nights to<br />

modify my presentation<br />

contents and to rehearse<br />

my presentation style.<br />

Seniors and secretaries<br />

from <strong>the</strong> department<br />

lent <strong>the</strong>ir help in all ways<br />

<strong>the</strong>y could. Special<br />

acknowledgements to<br />

Dr. James Yip, who lent me his books and articles on CPET and spent<br />

time explaining to me <strong>the</strong> concepts of CPET; and my mentor, <strong>Prof</strong> Ling,<br />

who patiently corrected my presentation and gave me invaluable advice.<br />

The presentation itself was an experience which one could<br />

not learn from books. It also provided me an opportunity to<br />

learn from my competitors, research methods and presentation<br />

skills. It widened my exposure to ongoing cardiovascular research<br />

in o<strong>the</strong>r instituitions.<br />

I feel most honoured to win <strong>the</strong> Young Investigator’s Award.<br />

I will continue to put in my best efforts and hope to do well in <strong>the</strong><br />

coming Asean’s Young Investigators’ Award presentation in Hanoi.<br />

THI PULSE | 12


Chicago ACC Success<br />

Dr<br />

Eric Chong, Cardiac Dept @ NUH<br />

American College of Cardiology<br />

Annual Scientific Meeting was held at<br />

Chicago this year. We had an<br />

outstanding 8 abstract presentations<br />

during <strong>the</strong> meeting. Dr Poh KK from<br />

our department was an invited faculty<br />

speaker in <strong>the</strong> echo seminar (E3:<br />

Essential Echocardiology with Experts)<br />

and A/<strong>Prof</strong> Tan HC was <strong>the</strong> only<br />

invited Singaporean faculty member at<br />

<strong>the</strong> ACC/SCAI (Society of Cardiovascular Angiography &<br />

Intervention) i2 Interventional Cardiology Summit meeting. It was<br />

snowing and freezing in Chicago at <strong>the</strong> beginning of <strong>the</strong> meeting.<br />

But <strong>the</strong> huge attending crowds warmed up <strong>the</strong> entire conference<br />

hall. Every room was crowded with attendees from all over <strong>the</strong><br />

world and it was hard to find oneself a standing place during <strong>the</strong><br />

more popular talks. Many world renowned speakers from<br />

institutions like <strong>the</strong> Cleveland and Mayo clinic gave impressive<br />

lectures. Dr Poh KK spoke on imaging of right heart masses which<br />

was well received by <strong>the</strong> packed<br />

international audience. In addition, Dr<br />

Abdul Razakrj bin Omar was<br />

conferred <strong>the</strong> ACC Fellowship at <strong>the</strong><br />

meeting. A/<strong>Prof</strong> Tan HC arranged a<br />

wonderful dinner meeting at a<br />

restaurant called <strong>the</strong> “Hugo Frogs”.<br />

This restaurant was so named because<br />

of its famous fried frog leg dishes.<br />

However, I think our Singapore styled<br />

frog dishes taste even better. It was a great pleasure to meet up<br />

with all <strong>the</strong> overseas NUH doctors in training during <strong>the</strong> dinner.<br />

Mark, Raymond, Chao Yang and Caroline gave speeches about <strong>the</strong>ir<br />

training in <strong>the</strong> States and shared <strong>the</strong>ir wonderful experiences. It<br />

was great to learn that NUH has provided us with a solid foundation<br />

in cardiology before <strong>the</strong> HMDP overseas stint. This was our first<br />

ever alumni ga<strong>the</strong>ring overseas. We hope that everyone will meet<br />

again in <strong>the</strong> next year’s ACC. It’s a truly memorable experience.<br />

FOR THE BETTER<br />

giving <strong>the</strong> sick heart a break...<br />

Goh Si Guim, CTVS @ NUH<br />

Heart disease is one of <strong>the</strong> leading causes of death worldwide.<br />

Open-heart surgery is a major operation indicated for<br />

patients to bring about relief of <strong>the</strong>ir debilitating symptoms and<br />

cardiac dysfunction.<br />

The surgeon requires a motionless heart and a bloodless<br />

field to do his job. Blood that normally course through <strong>the</strong> heart<br />

and lungs is diverted to <strong>the</strong> Heart Lung Machine. This provides<br />

an alternative and artificial means of keeping <strong>the</strong> blood going,<br />

mimicking <strong>the</strong> natural organs it replaces. The process is called<br />

cardiopulmonary bypass or more commonly known as Heart<br />

Bypass Surgery. The vital functions of <strong>the</strong> heart and lungs are<br />

now being performed by a mechanical device that works like <strong>the</strong><br />

real organs but look far from it!<br />

Once cardiopulmonary bypass is established, <strong>the</strong> heart is<br />

paralysed and <strong>the</strong> lungs shut down. The surgeon <strong>the</strong>n go about<br />

mending <strong>the</strong> hibernating heart.<br />

To quote one of our surgeons, “<strong>the</strong>se hearts get to rest,<br />

not ours!”<br />

Perfusionist is an alliedhealth<br />

specialty intimately<br />

related to cardiac surgery.<br />

They work alongside <strong>the</strong><br />

surgeons, anes<strong>the</strong>tists and<br />

nurses. They are specially trained professionals who manage <strong>the</strong><br />

heart lung machine and provide optimal life support for patients<br />

undergoing heart surgery.<br />

Cardiopulmonary bypass is a form of “insult” to <strong>the</strong><br />

integrity of <strong>the</strong> human body.”<br />

It elicits a host of adverse responses that put patient at<br />

fur<strong>the</strong>r risks. However, it is a necessary evil, from which, most<br />

patients benefit, coming out of it with a renewed lease of life. It<br />

enables <strong>the</strong>m to get back on with things <strong>the</strong>y would o<strong>the</strong>rwise be<br />

too incapacitated to perform.<br />

Today, some heart surgery procedures can be done without<br />

<strong>the</strong> need of <strong>the</strong> heart lung machine, known as beating heart surgery.<br />

Robotics is ano<strong>the</strong>r exciting advancement that has entered <strong>the</strong><br />

realm of heart surgery.<br />

THI PULSE | 13


NMRC Winning Grant<br />

Dr Chen Lin Yee, Cardiac Dept @ NUS, NUH<br />

“Identification of Novel Genetic Determinants<br />

of Atrial Fibrillation in an Asian Population”<br />

is a continuation of my research focus that<br />

started when I was undergoing cardiology and<br />

cardiac electrophysiology training at <strong>the</strong> Mayo<br />

Clinic College of Medicine, Rochester, MN.<br />

With start-up funds from <strong>the</strong> Yong Loo Lin<br />

School of Medicine, and <strong>the</strong> support of <strong>the</strong> Cardiac Department,<br />

NUH, and Department of Medicine, NUS, I started to lay <strong>the</strong><br />

groundwork for this project in August 2006. The process was made<br />

significantly easier through <strong>the</strong> guidance and mentorship of <strong>Prof</strong><br />

<strong>Chia</strong> Kee Seng, Center for Molecular Epidemiology, and Assoc <strong>Prof</strong><br />

Ling Lieng Hsi, Cardiac Department, NUH.<br />

Atrial fibrillation (AF) is <strong>the</strong> most common sustained arrhythmia,<br />

reaching epidemic proportions in <strong>the</strong> aging population, and resulting<br />

in significant morbidity, mortality, and socioeconomic burden. In a<br />

subset of younger patients (


1. Identify disease susceptibility polymorphisms for AF using<br />

candidate gene association analysis<br />

2. Define interaction of genetic factors with acquired factors in<br />

modifying AF risk and phenotypic expression<br />

3. Pave <strong>the</strong> way toward establishing a larger cohort to facilitate<br />

genome-wide association analysis in <strong>the</strong> future<br />

With preliminary data derived from this cohort of lone AF<br />

patients, I successfully obtained a National Medical Research Council<br />

grant that will support this research effort for <strong>the</strong> next three years.<br />

Presently, approximately 100 lone AF patients have been enrolled;<br />

I anticipate <strong>the</strong> enrollment process will be accelerated through<br />

collaboration of colleagues in National Heart Center and Tan Tock<br />

Seng Hospital. In addition, mutation scanning of candidate genes<br />

such as potassium and sodium channel genes is underway.<br />

This project would not have been possible if it was not<br />

for <strong>the</strong> support of <strong>the</strong> following: Chief, Cardiac Department,<br />

NUH, Assoc <strong>Prof</strong> Tan Huay Cheem; Head, Department of<br />

Medicine, NUS, <strong>Prof</strong> Ho Khek Yu; my mentors, <strong>Prof</strong> <strong>Chia</strong> and<br />

Assoc <strong>Prof</strong> Ling; colleagues in <strong>the</strong> Cardiac Department, NUH;<br />

research nurses, Ms. Quay Chwee Neo and Ms. Loh Fong Chee;<br />

collaborators in National Heart Center and Tan Tock Seng<br />

Hospital; <strong>the</strong> Yong Loo Lin School of Medicine and <strong>the</strong> National<br />

Medical Research Council. Ultimately, <strong>the</strong> success of this project<br />

will not only advance our understanding of a significant<br />

cardiovascular disease, but also underscore <strong>the</strong> feasibility and<br />

importance of multi-center collaboration in Singapore.<br />

CIT Beijing meetingDr Adrian<br />

Low, Cardiac Dept @ NUH<br />

CIT Beijing 2008 (China<br />

Interventional Therapeutics,<br />

Beijing) is an annual major<br />

meeting for interventional<br />

cardiologists. It was held this year<br />

from 19 to 23 March at <strong>the</strong> Beijing<br />

Interventional Convention Center.<br />

We were privileged to be given an<br />

opportunity for live-transmission<br />

to showcase our interventional techniques.<br />

The live-transmission was held on <strong>the</strong> morning of <strong>the</strong> 2nd<br />

day (20th March). We had 2 teams on hand: <strong>Prof</strong> Tan Huay Cheem<br />

and Dr Lim Ing Haan; Dr Adrian Low and <strong>Prof</strong> Ronald Lee. As was<br />

traditional, <strong>the</strong>re was an introductory segment to Singapore; fusing<br />

a blend of Singapore skyline, cultural activities, and images of our<br />

esteemed interventionists, to a pulsating soundtrack. The montage<br />

was expertly executed, earning praises even from professional media.<br />

<strong>Prof</strong> Tan started <strong>the</strong> live-transmission with a case of “instent<br />

restenosis”. This patient had had previous stenting to <strong>the</strong> heart<br />

artery but returned because of re-narrowing of <strong>the</strong> same segment.<br />

This was addressed with a novel drug-eluting balloon. This balloon<br />

is coated with a medication that inhibits recurrent renarrowing of<br />

<strong>the</strong> heart artery and has been shown in a recent published study to<br />

be effective at least in patients with narrowing of <strong>the</strong> leg arteries.<br />

The blockage was expertly cleared and treated with this new device<br />

with good results. In contrast to <strong>the</strong> usual placement of ano<strong>the</strong>r<br />

medicated stent, this approach does away<br />

with deploying an additional metal coat<br />

which may have deleterious consequences.<br />

The second case was an<br />

intervention of a saphenous vein graft.<br />

Traditionally, this is addressed using a distal<br />

protection device, ei<strong>the</strong>r a filter wire or<br />

balloon occlusion device, to catch <strong>the</strong><br />

anticipated downstream flow of clots and<br />

o<strong>the</strong>r debritus. We however demonstrated <strong>the</strong> safety and efficacy of<br />

a new proximal protection device. This was a special ca<strong>the</strong>ter with<br />

an inflatable balloon at its tip that can be inflated to seal off <strong>the</strong><br />

saphenous vein graft, <strong>the</strong>reby preventing flushing of debris<br />

downstream. An advantage of this is <strong>the</strong> virtual protection from all<br />

embolism, even with initial passage of our guide wire across <strong>the</strong><br />

blockage. This case was similarly well received. In addition, it was <strong>the</strong><br />

first time that a live-transmission of such as device was demonstrated<br />

regionally. The audience’s curiosity was obviously piqued.<br />

As usual, <strong>the</strong>re was <strong>the</strong> usual banter by <strong>the</strong> chairperson<br />

and o<strong>the</strong>r prominent interventional cardiologists. Our doctors<br />

joined in <strong>the</strong> spirited exchange and responded well to <strong>the</strong> variety<br />

of questions fielded. The teams enjoyed <strong>the</strong>mselves doing difficult<br />

cases under <strong>the</strong> glare of <strong>the</strong> media, and <strong>the</strong> live-transmission was<br />

all too soon over. As <strong>the</strong> day came to a close, <strong>Prof</strong> Tan made his<br />

sojourn to Beijing, representing our interventional cardiology team<br />

and of course NUH.<br />

THI PULSE | 15


happenings<br />

3D-<br />

TRANSESOPHAGEAL<br />

ECHOCARDIOGRAM<br />

WORKSHOP –<br />

ORGANISED BY<br />

PROF TI LIAN KAH<br />

AND DR SOPHIA<br />

ANG<br />

12 MARCH 2008<br />

CARDIAC DEPT MO FAREWELL DINNER<br />

28 APRIL 2008<br />

SINGAPORE CARDIAC<br />

SOCIETY 20 TH ANNUAL<br />

SCIENTIFIC MEETING<br />

22 MARCH 2008<br />

ACC 2008 PRESENTATIONS<br />

31 MARCH 2008<br />

PCI SIMULATOR COURSE<br />

24 MAY 2008<br />

THI PULSE | 16


GP SYMPOSIUM<br />

BY DR JAMES YIP<br />

AND DR ABDUL<br />

RAZAKJR OMAR<br />

12 APRIL 2008<br />

OVERSEAS FELLOW (INTERVENTIONAL<br />

CARDIOLOGY) FAREWELL DINNER<br />

19 NOVEMBER 2007<br />

OVERSEAS FELLOW (ECHOCARDIOGRAPHY)<br />

FAREWELL DINNER<br />

29 JANUARY 2008<br />

CCU PARTY<br />

14 JANUARY 2008<br />

“WHY THIS HEART SPECIALIST GETTING<br />

BUSY?” NEWSPAPER ARTICLE ON DR ABDUL<br />

RAZAKJR OMAR<br />

1 JUNE 2008<br />

THI PULSE | 17


abstracts<br />

AMERICAN COLLEGE OF CARDIOLOGY<br />

SCIENTIFIC SESSIONS 2008 AND SCAI-ACCI2,<br />

CHICAGO, 29 MARCH–1APRIL 2008<br />

1. The Impact of Gender on <strong>the</strong> Outcomes of Invasive versus<br />

Conservative Treatment of Patients with Acute Coronary<br />

Syndrome. Lee LC, Leng P, Tang T, Tan YL, Tee HW, Shi L,<br />

Poh KK, Tan HC<br />

2. Myocardial Doppler Imaging Can Detect Subclinical<br />

Cardiac Dysfunction After Anthracycline-Based<br />

Chemo<strong>the</strong>rapy. Wong RC, Gong L, Chan WX, Daw HY,<br />

Goh BC, Lee SC, Lim SE, Soo R, Ling LH<br />

3. Left Ventricular Performance and its Determinants<br />

Immediately Prior to and Post-Marathon Running:<br />

Insights from Two Dimensional Speckle Tracking<br />

Echocardiography and Serum Biomarkers. Poh KK,<br />

Tournoux FB, Picard MH, Wood MJ<br />

4. One -Year Clinical Follow-Up of Endo<strong>the</strong>lial Progenitor<br />

Cell Capture Stent versus Uncoated Stent in Patients<br />

Undergoing Primary Percutaneous Coronary Intervention<br />

for Acute Myocardial Infarction. Lee YP, Tay Edgar, Melissa<br />

Co, Yeo WT, Lee CH, Low A, Teo SG, Lim J, Lim IH, Lim<br />

YT, Tan HC.<br />

5. Risk Scoring System for Prediction of Contrast Induced<br />

Nephropathy In Patients With Preexisting Renal<br />

Impairment Undergoing Percutaneous Coronary<br />

Intervention. Chong E, Shen L, Poh KK, Tan HC<br />

6. Comparison of Eighteen-Month Clinical Outcomes of<br />

Endo<strong>the</strong>lial Progenitor Cell Capture Stent versus<br />

Sirolimus-Eluting Bioabsorbable Polymer-Coated Stent<br />

versus Bare Metal Stents In Patients Undergoing Primary<br />

Percutaneous Coronary Intervention for Acute Myocardial<br />

Infarction. Chong E, Lee CH, Shen L, Low A, Teo SG, Poh<br />

KK, Tan HC<br />

7. Risk and Clinical Predictors for Patients with Unstable<br />

Angina and Non-ST Segment Elevation Myocardial<br />

Infarction Post Early Percutaneous Coronary Intervention.<br />

Chong E, Shen L, Poh KK, Tan HC<br />

8. Comparison of Risk Predictors for Contrast Induced<br />

Nephropathy Post Percutaneous Coronary Intervention<br />

in Patients with Normal versus Impaired Baseline Renal<br />

Function. Chong E, Shen L, Poh KK, Tan HC<br />

9. Relation of ventricular-arterial coupling to exercise<br />

capacity in ischemic cardiomyopathy: a cardiac multimodality<br />

imaging study. Wong R, Dumont C, Austin B,<br />

Kwon D, Flamm S, Thomas J, Starling R, Desai M.<br />

10. Ventricular-vascular stiffening is more strongly associated<br />

with Exercise Capacity compared to left ventricular<br />

outflow tract gradient in Hypertrophic Cardiomyopathy.<br />

Austin B, Kwon D, Dumont C, Wong R, Thamilarasan M,<br />

Flamm S, Lever H, Desai M.<br />

11. Greater degree of LV septal hypertrophy and associated<br />

coronary arteriole dysplasia are significantly associated<br />

with myocardial fibrosis in hypertrophic cardiomyopathy.<br />

Kwon D, Rodriguez E, Wong R, Tan C, Thamilarasan M,<br />

Smedira N, Lytle B, Lever H, Desai M.<br />

19 TH ANNUAL SCIENTIFIC SESSIONS OF THE<br />

AMERICAN SOCIETY OF ECHOCARDIOGRAPHY,<br />

TORONTO, CANADA, 7-11 JUNE 2008<br />

1. Predictors of Pulmonary Artery Systolic Pressure in<br />

Significant Mitral Regurgitation Secondary to Mitral Valve<br />

Prolapse. Zhang J, Lee LC, Tan HC, Yip JWL, Poh KK<br />

2. Progression and Predictors of Left Ventricular Dilation<br />

Secondary to Significant Organic Mitral Regurgitation:<br />

Insights from Tissue Doppler Imaging. Zhang J, Lee LC,<br />

Tan HC, Yip JWL, Yeo TC, Poh KK<br />

3. Reperfusion <strong>the</strong>rapies reduce ischaemic mitral<br />

regurgitation following an inferoposterior ST elevation<br />

myocardial infarction. Lee LC, Poh KK, Tee HW, Tan HC,<br />

<strong>Chia</strong> BL, Zhang J, Ong HY, Yeo TC<br />

4. Late Diastolic Mitral Annular Velocity in Aortic Stenosis:<br />

Relation to Left Atrial Morphophysiology. Chan WX,<br />

Gong L, Poh KK, Daw HY, Ling LH<br />

HEART RHYTHM 2008, SAN FRANCISCO,<br />

CALIFORNIA, USA, 14-17 MAY 2008<br />

1. Utility of Electrocardiogram and Programmed Ventricular<br />

Stimulation for Risk Stratification in Brugada Syndrome.<br />

Singh D, Chong E, Seow SC, Poh KK, Omar AR<br />

ESC HEART FAILURE CONGRESS 2008, MILAN,<br />

ITALY, 14-17 JUNE 2008<br />

1. An Asian comparison of cardiologist versus noncardiologist<br />

care of heart failure. Ling LF, Shen L, Chai P<br />

THI PULSE | 18


publications<br />

1. European Heart Journal 2008; In Press. Assessing Aortic<br />

Valve Area in Aortic Stenosis by Continuity Equation – A<br />

Novel Approach using Real-time Three Dimensional<br />

Echocardiography. Poh KK, Levine RA, Solis J, Shen L,<br />

Flaherty M, Kang YJ, Guerrero JL, Hung J<br />

2. Circulation 2008; In Press. A Phase 1b Randomized Study<br />

of Antidote-Controlled Modulation of Factor IXa Activity<br />

in Patients with Stable Coronary Artery Disease. Mark Y.<br />

Chan, Mauricio G. Cohen, Christopher K. Dyke, et al.<br />

3. Journal Thromb Haemost 2008 May; 6(5):789-96. A<br />

randomized, repeat-dose, pharmacodynamic and safety<br />

study of an antidote-controlled factor IXa inhibitor. Chan<br />

MY, Rusconi CP, Alexander JH, Tonkens RM, Harrington<br />

RA, Becker RC.<br />

4. Journal Nucl Cardiol 2007 Jul; 14(4):617-20. Hybrid<br />

cardiac imaging: complementary roles of CT angiography<br />

and PET in a patient with a history of radiation <strong>the</strong>rapy.<br />

Hong EC, Kimura-Hayama ET, Di Carli MF.<br />

5. Circulation 2008 Apr 1;117(13):1693-700. Interrelation<br />

of coronary calcification, myocardial ischemia, and<br />

outcomes in patients with intermediate likelihood of<br />

coronary artery disease: a combined positron emission<br />

tomography/computed tomography study. Schenker MP,<br />

Dorbala S, Hong EC, et al.<br />

6. European Journal Neurol 2008; In Press. Takotsubo<br />

cardiomyopathy associated with status epilepticus. Seow<br />

SC, Lee YP, Teo SG, Hong EC, Lee CH.<br />

7. Annals of Academy of Medicine, Singapore 2008 Mar;<br />

37(3):243-2. A Case of Myopericarditis in a Patient with<br />

Methicillin-resistant Staphylococcus aureus (MRSA)<br />

Community-acquired Pneumonia. Lee YP, Hoi WH,<br />

Wong RC.<br />

8. Journal Heart Lung Transplant 2008. Tricuspid<br />

regurgitation after cardiac transplantation: an old problem<br />

revisited. Wong RC, Abrahams Z, Hanna M, et al.<br />

9. Echocardiography 2008; In Press. Echocardiographic Left<br />

Ventricular Mass in a Multi-ethnic Sou<strong>the</strong>ast Asian<br />

Population: Proposed New Gender and Age-Specific<br />

Norms, Wong RC, Gupta A, Yip JWL, Yang H, Ling LH.<br />

10. International Journal of Cardiology; In Press. Fulminant<br />

dengue myocarditis masquerading as acute myocardial<br />

infarction. Lee CH, Teo C, Low AF.<br />

11. Annals of Academy of Medicine, Singapore 2008 May; 37<br />

(5):365-7. Risk Factor <strong>Prof</strong>ile and Treatment Patterns of<br />

Patients wih A<strong>the</strong>rothrombosis in Singapore: Insight from<br />

<strong>the</strong> REACH Registry. Yeo TC, Chan YH, Low LP,<br />

Venketasubramanian N, Lim SC, Tay JC, Tan RS, Eng P,<br />

Lingamanaicker J.<br />

12. European Journal Echocardiology 2008; In Press.<br />

Prognostic value of Left Atrial Size in Chronic Kidney<br />

Disease. Chan MY, Wong HB, Ong HY, Yeo TC.<br />

BOOK CHAPTER<br />

1. Post-operative Management of <strong>the</strong> Cardiac Transplant<br />

Patient. Immunosuppression and Drug Interaction.<br />

Fink J, Wong RC, Sipahi I, Taylor D.<br />

new doctors<br />

on board<br />

National University Hospital<br />

Dr Benjamin Chua Soo Yeng – Associate Consultant,<br />

Vascular Surgery- CTVS<br />

Dr Sujeeb Rajbhandari – <strong>Honorary</strong> Fellow, Cardiology<br />

Dr Yeo Wee Tiong promoted to Registrar, Cardiology<br />

THI PULSE | 19


directory<br />

awards<br />

THE HEART INSTITUTE,<br />

NATIONAL HEALTHCARE GROUP<br />

Secretariat Office<br />

c/o Cardiac Department<br />

National University Hospital<br />

5 Lower Kent Ridge Road<br />

Level 3, Main Building<br />

Singapore 119074<br />

Tel 6772 5596<br />

Fax 6778 6057<br />

Website<br />

www.thi.nhg.com.sg<br />

ALEXANDRA HOSPITAL<br />

378 Alexandra Road<br />

Singapore 159964<br />

Tel 6472 2000<br />

Fax 6379 3880<br />

Appointment Line 6476 8828<br />

Fax 6379 3880<br />

Specialist Outpatient Clinic 6379 3190<br />

NATIONAL UNIVERSITY HOSPITAL<br />

5 Lower Kent Ridge Road<br />

Singaore 119074<br />

Tel 6779 5555<br />

Fax 6779 5678<br />

Cardiac Clinic H<br />

Clinic Appointment 6772 5730<br />

Fax 6775 1617<br />

Cardiac Centre<br />

Clinic Appointment 6772 5277/6772 5278<br />

Fax 6772 5279<br />

TAN TOCK SENG HOSPITAL<br />

11 Jalan Tan Tock Seng<br />

Singapore 308433<br />

Tel 6526 6011<br />

Fax 6252 7282<br />

Cardiology Clinic<br />

Central Appointment 6357 7000<br />

Fax 6357 7011<br />

Private Appointment 6357 8000<br />

Fax 6357 7011<br />

Direct Line to Clinic 6357 8011<br />

Fax 6357 8680<br />

GEMS AWARDS MARCH 2008<br />

Go <strong>the</strong> extra miles, are Exemplary role models who<br />

Made a difference and Spectacular contributions<br />

Dr Chai Ping, Consultant, Cardiac<br />

Dr Low Fatt Hoe Adrian, Consultant, Cardiac<br />

Dr Ooi Oon Cheong, Associate Consultant, CTVS<br />

THORACIC SURGERY FOUNDATION FOR RESEARCH<br />

AND EDUCATION SCHOLARSHIP<br />

The Heller School Executive Leadership Program in<br />

Health Policy and Management – An intesive<br />

program in health policy and management for <strong>the</strong><br />

senior level health care providers.<br />

Brandeis University, Walktham, Massachusetts, USA, 2008<br />

Dr Ooi Oon Cheong, Associate Consultant, Cardiothoracic Surgery<br />

NATIONAL RESEARCH FOUNDATION<br />

Ministry of Health Healthcare Research Scholarship<br />

(Master of Clinical Investigation, MCI)<br />

Dr Ooi Oon Cheong<br />

ELECTION AS MEMBER OF THE AMERICAN<br />

ASSOCIATION FOR THORICAC SURGERY<br />

<strong>Prof</strong> Lee Chuen Neng has been elected as Member of<br />

<strong>the</strong> American Association for Thoracic Surgery, being<br />

one of <strong>the</strong> 12 cardiothoracic surgeons to be elected<br />

outside of North America this year. Membership of<br />

AATS is prestigious and <strong>Prof</strong> Lee is <strong>the</strong> only one from<br />

Singapore so far. This took place during <strong>the</strong> recent<br />

88 th Annual Meeting of <strong>the</strong> AATS in Washington DC,<br />

USA from May 10–14, 2008

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