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Scientific Report 2007-2009 Laboratories and Facilities of the Department of Physics L7. Nuclear Magnetic Resonance (NMR) Laboratory The NMR Laboratory in Physics Department of Sapienza University of Rome, has been engaged in developing researches on Nuclear Magnetic Resonance since almost 25 years. Research interests include theoretical speculation and experimental investigation in the field of Nuclear Magnetic Resonance. All the activities have been characterized by a specific orientation to applicative fields with a potentially high clinical impact. Some research lines are currently at the stage of basic research, some others are in a transitional stage between basic research and clinical application. The main research tools are NMR related techniques, including both Spectroscopy and Imaging. Investigation targets are: materials and biomaterials (confined water, Figure 1: 9.4T Bruker Avance gels, macromolecules) and living systems (cells, ex-vivo tissues, in-vivo animal models, humans). In the laboratory are located : a 9.4T Bruker Avance MR spectrometer for in vitro experiments (equipped with a microimaging, multinuclear probe and high performance gradients) and a 7T Bruker Biospec MR Tomography (equipped with several coils to perform multinuclear experiments in vitro and in animal models). For in vivo diagnostic applications in humans, the NMR laboratory has strict interactions with the Neuroimaging Laboratory of Santa Lucia Foundation (equipped with a 3T head-dedicated Scanner) and with the department of Radiology of Tor Vergata University (equipped with a 3T and 1.5T whole body scanners. Specific research activities are: -MR investigations of skeletal system (spongy bone, cartilage, muscle) using multi-parametric approach: 1) conventional relaxation parameters and diffusion coefficient correlated to spectroscopic quantitative analysis (translational clinical research) 2) Non convention NMR technique, such Figure 2: 7T Bruker Biospec as DTI or 23Na-triple-quantum (research activity) - MR investigations at high magnetic field (7T) of glioma animal model to optimize BNCT (Boron Neutron Capture Therapy) using: 1) Conventional and non conventional Diffusion Tensor Imaging (DTI) techniques 2) Imaging and Spectroscopic techniques performed on 19F nuclei to detect spatial distribution of fluorinated BNCT-carriers and to study their pharmacokinetics -Study and Development of new MR Multi Quantum coherences and anomalous diffusion approaches for 1) Materials application and investigation 2) Tissue investigation 3) Neuroradiological applications. http://fslsrv3/default.aspx Related research activities: C40, C41. Sapienza Università di Roma 181 Dipartimento di Fisica
Scientific Report 2007-2009 Laboratories and Facilities of the Department of Physics L8. DECA NMR Laboratory The DECA NMR Laboratory is active from many years in different scientific areas regarding Magnetic Resonance Imaging, solid state NMR, diagnostic for Cultural Heritage, biomedicine, etc. The laboratory’s activities have spread from the realization of methods for NMR imaging of low sensitivity nuclei and solid-state spin systems, to the development of original approaches for in situ non-invasive study of Cultural Heritage items. The laboratory is provided with two main NMR experimental sets that may run independently each other. One is based on a high-resolution NMR spectrometer, a Bruker Avance 300 ultra-shield spectrometer, which utilizes a 7 T superconducting magnet tunable on a wide range of nuclei to make chemical-shift and relaxation measurements on a very large number of molecular species. The spectrometer is equipped with an ultra-intense magnetic gradient which can produce gradients as intense as 1250 Gauss/cm and it allows measuring molecular self-diffusion coefficient up to about 10 −16 m 2 /s. With this experimental apparatus, which posses also a controlling temperature capability, it has been performed research concerning transport properties on polymers and cell membranes. The second experimental apparatus is based on a single-sided mobile low-field NMR probe (Bruker NMR ProFiler) equipped with glass caskets and vacuum system for temperature and humidity specimens conditioning. This experimental set works at a Larmor frequency of about 18 MHz and utilizes a probe that includes permanent magnets. The electronics is based on the Bruker Minispec apparatus and may be used in situ since it is fully transportable. By this apparatus a number of application have been ideated to monitoring and characterizes Cultural Figure 1: The high-resolution NMR Bruker Avance 300 ultrashield spectrometer. Heritage items. http://deca.phys.uniroma1.it/ Related research activities: C42. Sapienza Università di Roma 182 Dipartimento di Fisica
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