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Scientific Report 2007-2009<br />
Laboratories and Facilities of the Department of Physics<br />
L7. Nuclear Magnetic Resonance (NMR) Laboratory<br />
The NMR Laboratory in Physics Department of <strong>Sapienza</strong> University<br />
of Rome, has been engaged in developing researches on<br />
Nuclear Magnetic Resonance since almost 25 years. Research<br />
interests include theoretical speculation and experimental investigation<br />
in the field of Nuclear Magnetic Resonance. All the activities<br />
have been characterized by a specific orientation to applicative<br />
fields with a potentially high clinical impact. Some research<br />
lines are currently at the stage of basic research, some<br />
others are in a transitional stage between basic research and<br />
clinical application. The main research tools are NMR related<br />
techniques, including both Spectroscopy and Imaging. Investigation<br />
targets are: materials and biomaterials (confined water,<br />
Figure 1: 9.4T Bruker Avance<br />
gels, macromolecules) and living systems (cells, ex-vivo tissues,<br />
in-vivo animal models, humans).<br />
In the laboratory are located : a 9.4T Bruker Avance MR spectrometer<br />
for in vitro experiments (equipped with a microimaging,<br />
multinuclear probe and high performance gradients) and a 7T<br />
Bruker Biospec MR Tomography (equipped with several coils to<br />
perform multinuclear experiments in vitro and in animal models).<br />
For in vivo diagnostic applications in humans, the NMR laboratory<br />
has strict interactions with the Neuroimaging Laboratory<br />
of Santa Lucia Foundation (equipped with a 3T head-dedicated<br />
Scanner) and with the department of Radiology of Tor Vergata<br />
University (equipped with a 3T and 1.5T whole body scanners.<br />
Specific research activities are: -MR investigations of skeletal system<br />
(spongy bone, cartilage, muscle) using multi-parametric approach:<br />
1) conventional relaxation parameters and diffusion coefficient<br />
correlated to spectroscopic quantitative analysis (translational<br />
clinical research) 2) Non convention NMR technique, such<br />
Figure 2: 7T Bruker Biospec<br />
as DTI or 23Na-triple-quantum (research activity) - MR investigations<br />
at high magnetic field (7T) of glioma animal model to optimize BNCT (Boron Neutron Capture Therapy) using: 1)<br />
Conventional and non conventional Diffusion Tensor Imaging (DTI) techniques 2) Imaging and Spectroscopic techniques performed<br />
on 19F nuclei to detect spatial distribution of fluorinated BNCT-carriers and to study their pharmacokinetics -Study<br />
and Development of new MR Multi Quantum coherences and anomalous diffusion approaches for 1) Materials application<br />
and investigation 2) Tissue investigation 3) Neuroradiological applications.<br />
http://fslsrv3/default.aspx<br />
Related research activities: C40, C41.<br />
<strong>Sapienza</strong> Università di Roma 181 Dipartimento di Fisica