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Scientific Report 2007-2009
Laboratories and Facilities of the Department of Physics
L7. Nuclear Magnetic Resonance (NMR) Laboratory
The NMR Laboratory in Physics Department of Sapienza University
of Rome, has been engaged in developing researches on
Nuclear Magnetic Resonance since almost 25 years. Research
interests include theoretical speculation and experimental investigation
in the field of Nuclear Magnetic Resonance. All the activities
have been characterized by a specific orientation to applicative
fields with a potentially high clinical impact. Some research
lines are currently at the stage of basic research, some
others are in a transitional stage between basic research and
clinical application. The main research tools are NMR related
techniques, including both Spectroscopy and Imaging. Investigation
targets are: materials and biomaterials (confined water,
Figure 1: 9.4T Bruker Avance
gels, macromolecules) and living systems (cells, ex-vivo tissues,
in-vivo animal models, humans).
In the laboratory are located : a 9.4T Bruker Avance MR spectrometer
for in vitro experiments (equipped with a microimaging,
multinuclear probe and high performance gradients) and a 7T
Bruker Biospec MR Tomography (equipped with several coils to
perform multinuclear experiments in vitro and in animal models).
For in vivo diagnostic applications in humans, the NMR laboratory
has strict interactions with the Neuroimaging Laboratory
of Santa Lucia Foundation (equipped with a 3T head-dedicated
Scanner) and with the department of Radiology of Tor Vergata
University (equipped with a 3T and 1.5T whole body scanners.
Specific research activities are: -MR investigations of skeletal system
(spongy bone, cartilage, muscle) using multi-parametric approach:
1) conventional relaxation parameters and diffusion coefficient
correlated to spectroscopic quantitative analysis (translational
clinical research) 2) Non convention NMR technique, such
Figure 2: 7T Bruker Biospec
as DTI or 23Na-triple-quantum (research activity) - MR investigations
at high magnetic field (7T) of glioma animal model to optimize BNCT (Boron Neutron Capture Therapy) using: 1)
Conventional and non conventional Diffusion Tensor Imaging (DTI) techniques 2) Imaging and Spectroscopic techniques performed
on 19F nuclei to detect spatial distribution of fluorinated BNCT-carriers and to study their pharmacokinetics -Study
and Development of new MR Multi Quantum coherences and anomalous diffusion approaches for 1) Materials application
and investigation 2) Tissue investigation 3) Neuroradiological applications.
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Related research activities: C40, C41.
Sapienza Università di Roma 181 Dipartimento di Fisica