9th European Downstream Technology Forum & 3rd Upstream Technology ...

9 th European Downstream Technology Forum &
3 rd Upstream Technology Forum – Linked Event
September 9 – 10 | 10 – 11, 2013
Sartorius College, Goettingen, Germany
turning science into solutions

Invitation
Agenda
Chairs
Dr. Christel Fenge, Davy De Wilde Fermentation Technologies,
Sartorius Stedim Biotech, Germany
Upstream and Downstream
Processing: One Common Goal
Successful process optimization
in upstream has led to increased
cell densities and product titers.
But what does this mean for downstream
processing and purification
of the final drug product?
These modern, intensified
production processes are pushing
the bottleneck more and more
towards downstream.
The need to address this has become
stronger than ever before.
This year, in an attempt to bring
upstream and downstream specialists
closer together, our established
Upstream Technology Forum and
European Downstream Technology
Forum will be held back-to-back. It
will offer you the opportunity to
gain knowledge and share experience
with experts from the industry.
The joined session will further provide
an opportunity for interdisciplinary
discussions to address the
bottlenecks at the interfaces of
upstream and downstream.
Topics will include challenges of
high titer processes and potential
resolutions, Quality by Design and
continuous bioprocessing.
Take a look at the respective agenda
and select which of the forums you
would like to attend.
You will find up-to-date information
posted on our website:
www.sartorius.com/
upstream-downstream-forum.
Seize the opportunity of this unique
set-up and book both events as a
package. Broaden your process
understanding and update your
knowledge in upstream and downstream
processing while meeting
experts from the industry.
Monday, September 09
10:00 – 11:00
Plant Tour
11:00 – 11:30
Registration
Upstream Forum
Lunch | Exhibition
12:30 – 12:45
Welcome & Introduction
Dr. Oscar-Werner Reif,
Executive Vice President,
Member of the Board,
Sartorius Stedim Biotech,
Germany
r Session 1:
Vaccines & Cell Culture Media
12:45 – 13:30
Keynote Presentation
Disposable bioreactors: How to
integrate them into your Process
Development Platform?
Jean-Francois Chaubard,
Director, Cell & Viral
Technologies, GSK Vaccines,
Belgium
13:30 – 14:00
Lecture
Making the Choice between
Suspension & Microcarriers
for Animal Vaccine Processes:
a Comparison Study between
Single-use and Multi-use
Bioreactors
Dr. Lidia Garcia Coronado,
Senior Scientist, Veterinary
Medicine Research and
Development, Zoetis Manufacturing
& Research, Spain, S.L.
14:00 – 14:30
Lecture
Media optimization for enhanced
process performance
t.b.d.
Coffee Break | Exhibition
r Session 2:
Process Scale-up &
Manufacturing
15:00 – 15:30
Lecture
Scale up from 2L – 15000L:
Challenges and Lessons Learned
Dr. Michelangelo Canzoneri,
Head of Laboratory Upstream
Development, Sanofi-Aventis
Deutschland, Germany
15:30 – 16:00
Lecture
Implementation of Single-use
Bioreactors for Scale-up &
Biologics Production
Dr. Anne Gilbert, USP
Director, Product & Process
Development, Novasep Process,
Belgium
Short Break
16:15 – 16:45
Lecture
Strategies towards Superior
Single-use Bioreactors
Dr. Gerhard Greller, R&D
Director Upstream Technology,
Sartorius Stedim Biotech,
Germany
16:45 – 17:15
Lecture
t.b.d.
Christopher Cruz, Senior Associate
Development Scientist,
Bayer Healthcare, USA
17:15 – 17:35
Q & A | Panel discussion
Closing of day 1
18:30
Transfer to Networking Dinner

Agenda
Chairs
Dr. Uwe Gottschalk, Dr. Susanne Roederstein
Purification Technologies, Sartorius Stedim Biotech, Germany
Tuesday, September 10
r Session 3:
Process Analytical Technology
(PAT)
08:30 – 9:00
Lecture
Set Up of Glucose Control Loops
for Cell Culture based on the
Online Glc | Lac Measurement
Dr. Wolfgang Paul, Senior
Scientist, Roche, Germany
09:00 – 09:30
Lecture
Realtime Multiparameter
Monitoring during Bacillus
Spore Production by NIR-Online
Spectroscopy
Dr. Dirk Bergmaier, Senior
Scientist, Christian Hansen,
Germany
09:30 – 10:00
Lecture
Mitigating the Biosafety and
Financial Risk of Human Error
when Using Single Use
Dr. Martin Dahlberg,
R&D Manager Instrumentation
& Control, Sartorius Stedim
Biotech, Germany
Coffee break | Exhibition
r Joint Session
Upstream & Downstream
10:30 – 10:45
Welcome & Introduction
Joint Session
Reinhard Vogt,
Executive Member of the Board,
Sartorius Stedim Biotech
10:45 – 11:30
Keynote Presentation
One Common Goal
Dr. Peter Krämer, IA C&B-
Engineering Development,
Sanofi Frankfurt, Germany
11:30 – 12:00
Lecture
Facility of the Future: How Disposables
Support that Concept
Dr. Berthold Bödeker, Global
Biologics Biotech Development,
Bayer Pharma AG, Germany
12:00 – 12:30
Lecture
Virus Filtration of Cell Culture
Media - Dos and Don’ts
Dr. Volkmar Thom, Director,
Precipitation Technologies,
Sartorius Stedim Biotech,
Germany
Lunch Break | Exhibition
13:30 – 14:00
Lecture
Do we still need Centrifugation
for Cell Removal?
Laure Landric-Burtin, Head of
Bioprocesses, DSP Group,
Sanofi Vitry, France
14:00 – 14:30
Lecture
Strategies During the
Development of Tangential Flow
Filtration as Primary Recovery
Step During Microbial Based
Production Processes
Dr. Guido Seidel, Head of
Operations, Wacker, Germany
14:30 – 15:00
Lecture
Applied Chemometrics Enabling
Efficient Bioprocess Development
& Robust Manufacturing
t.b.d.
15:00 – 15:15
Closing Remarks
Upstream Forum
Coffee Break | Exhibition|
Plant Tour
r Start Downstream
r Session 1:
Innovation in Downstream
Processing
16:00 – 16:30
Lecture
Innovations in Biopharmaceutical
Production– A Manufacturer’s
Perspective
Abhinav Shukla, Ph.D., Vice
President, Process Development
and Manufacturing,
KBI Biopharma, USA
16:35 – 17:05
Lecture
Effect of Membrane Properties
and Operating Mode on Small
Virus Filtration Performance
Alex Seay, Senior Scientist,
Late Stage Development,
Genentech, USA
Q & A
Closing of day 1
18:30
Transfer to Networking Dinner

Agenda
Chairs
Dr. Uwe Gottschalk, Dr. Susanne Roederstein
Purification Technologies, Sartorius Stedim Biotech, Germany
Wednesday, September 11
r Session 2:
Single-use in Downstream
Processing
9:00 – 9:45
Keynote Presentation
A CMOs View on Platform
Technologies
Dr. Martin Smith, Head of
Mammalian Development
Services, Lonza Biologics, UK
9:45 – 10:15
Lecture
Full Disposable Solutions in
GMP Downstream Processing
Gunther Jaenicke,
Clinical Supply DSP,
Boehringer Ingelheim, Germany
Short Break
10:30 – 11:00
Lecture
A CMOs Example of a Single-use
GMP Downstream Process
Adriana Kiędzierska-Mencfeld,
GMP-Production Specialist,
Mabion, Poland
11:00 – 11:45
Technology Updates
Amélie Raveneau, Project
Manager, Virus & Contaminant
Clearance, Europe
Claire Roulin, Process Development,
Central & South Europe
Sartorius Stedim Biotech
Coffee Break | Exhibition
r Session 3:
Polishing
12:15 – 12:45
Lecture
Inactivation of Viruses by UVC
Treatment
Katherine F. Bergmann,
Manager, Viral Safety and
Clearance Services, Eurofins
Lancaster Laboratories, USA
12:45 – 13:15
Lecture
t.b.d.
t.b.d.
13:15 – 13:30
Closing Remarks
Downstream Forum
Lunch Break | Plant Tour
14:00
End of Forum
We look forward to welcoming you
in Goettingen, Germany.
Conference address
Sartorius College
Otto Brenner Str. 20
37079 Goettingen, Germany
Phone +49.551.308.2101
Networking dinner – Monday
t.b.d.
Networking dinner – Tuesday
Restaurant “Graf Isang”
Seestrasse 37
37136 Seeburg, Germany
Phone +49.5507.919880
We encourage you to forward this
invitation to interested colleagues.
Sartorius College, Goettingen

Venue
Sartorius College
Otto-Brenner-Strasse 20
37079 Goettingen, Germany
www.sartorius.com
Phone +49.551.308.2101
Transportation
The nearest airport is Hannover,
about 11 hours by train or car
to Goettingen. The train station is
10 min from the College by taxi.
Directions
On motorway A7 (Hannover-
Kassel) take the exit for
Goettingen Nord (72). Take
first exit for Industriegebiet,
take first exit in roundabout.
Then at the next light, take a left.
The College will appear on
the left-hand side.
Your contacts
For Germany, Austria, Switzerland
and the Netherlands:
Beate Sommerfeld
Sartorius Stedim Biotech,
Goettingen
Phone +49.551.308.3318
Fax +49.551.308.3492
beate.sommerfeld@sartorius-stedim.com
For all other countries:
Downstream Forum:
Elke Giebeler
Sartorius Stedim Biotech,
Goettingen
Phone +49.551.308.2032
Fax +49.551.308.3705
elke.giebeler@sartorius-stedim.com
Upstream Forum:
Nadine Engel
Sartorius Stedim Biotech,
Goettingen
Phone +49.551.308.4129
Fax +49.551.308.2377
nadine.engel@sartorius-stedim.com
Registration
The conference fee for joining
Downstream or Upstream Forum
(including joint session) is:
¤ 395 + 19 % VAT
¤ 100 + 19 % VAT for academia
This includes the networking dinner,
all breaks and lunches.
The fee for participation in the
combined Forum (Upstream and
Downstream) is:
¤ 495 + 19 % VAT
¤ 150 + 19 % VAT for academia
This includes the networking
dinner, all breaks and lunches.
To register, please either
– register on the Web:
www.sartorius.com/upstream-downstream-forum
– call or e-mail listed contacts

Accommodation
We have arranged discounted
rates for accommodation in the
following hotels in Goettingen:
***Hotel Rennschuh
Rate standard category 45.00 ¤ p.P.
Rate comfort category 51.00 ¤ p.P.
www.rennschuh.de
Phone: +49.551.9009.0
****Best Western Parkhotel Ropeter
Rate standard category 73.00 ¤ p.P.
Rate business category 79.00 ¤ p.P.
www.parkhotel-ropeter.
bestwestern.de
Phone +49.551.902.0
****Best Western Vital Park,
Heiligenstadt
Rate 90.00 ¤ p.P.
www.hotel-am-vitalpark.bestwestern.de
Phone: +49.3606.66370
****Hotel zum Löwen,
Duderstadt
Rate 95.00 ¤ p.P.
www.die2hotels.de
Phone +49.5527.849000
Parkhotel Ropeter
Further hotel infomation:
www.sartorius.com/
upstream-downstream-forum
Shuttle Service
We arrange a shuttle service
from the Sartorius College to the
hotels above and vice versa.
You will find detailed information
in your conference information
and at the hotel receptions.
We advise you that photographs
will be taken at the event which
may be published later. In case you
do not consent to such publication,
we ask you to inform us.