Sjoerd Rodenhuis - NKI / AvL

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The validation of 2 Discoveries 1. Should intensive chemotherapy with bifunctional alkylators be employed for tumors enriched for a homologous recombination defect (BRCA‐like aCGH) ? 2. Paired CE‐MRI is very good in predicting pCR in TN disease. Should ddAC continue in the presence of a favorable MRI‐response or should every patient have the benefit of a taxane?
Neo‐TN study (Req. 270 patients) N=118 Required •Multi‐center study (NL) •First 56 patients entered (1‐11‐11) •Grants from KWF and SK‐Foundation
Page 1 and 2: 10 jaar Neoadjuvante Studies in het
Page 3 and 4: Verhoging van de effectiviteit van
Page 5 and 6: Verhoging van de effectiviteit van
Page 7 and 8: IHC Subtype and Pathol. CR (ddAC fo
Page 9 and 10: Neoadjuvant Response Index (NRI) NR
Page 11 and 12: NRI in 118 patients with TN Breast
Page 13 and 14: TN tumors. Initial Regimen = ddAC E
Page 15 and 16: Which Neoadjuvant Drug Regimen is B
Page 17 and 18: Identificatie van Resistentiegenen
Page 19 and 20: Genes Chromosomes Cancer 2011, 50:
Page 21 and 22: N Engl J Med 349:7‐16, 2003 Recur
Page 23: Findings in TN (Basal‐like) BC
Page 27 and 28: Lips E, Ladach N, et al., Breast Ca
Page 29 and 30: Neo‐TN study (Req. 270 patients)

Sjoerd Rodenhuis - NKI / AvL

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