10 A niversary of IIMCB

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DEGREES • Professor, 1993 • DSc. Habil., Nencki Institute of Experimental Biology PAN, Warsaw, Poland, 1987 • PhD in biochemistry, Nencki Institute of Experimental Biology PAN, Warsaw, 1980 • MSc in biochemistry, Warsaw University, 1976 POST-DOCTORAL TRAINING 1981-1984 Visiting Fellow, Laboratory of Cell Biology headed by E.D. Korn, National Institutes of Health, Bethesda, MD, USA PROFESSIONAL EMPLOyMENT 2002 present Director of the Institute and Head of the Laboratory of Neurodegeneration, IIMCB 2000-2001 Director, Centre of Excellence for Studies on Mechanisms of Neurodegeneration Phare Sci-Tech II located at the Nencki Institute of Experimental Biology PAN, Warsaw 1999-2001 Acting Director, IIMCB; Organizer and Director of Centenarian Program 1996-2002 Head of Laboratory of Calcium Binding Proteins, the Nencki Institute of Experimental Biology PAN, Warsaw 1992-1995 Visiting Professor at the National Institute of Mental Health, Laboratory of Clinical Science, Bethesda, MD, USA 1991-1992 Deputy Director (Scientific Director), Nencki Institute of Experimental Biology PAN, Warsaw 1986-1992 Associate Professor and Head of Laboratory of Calcium Binding Proteins, Nencki Institute of Experimental Biology PAN, Warsaw 1984-1985 Research Associate, Nencki Institute of Experimental Biology PAN, Warsaw 1981-1984 Visiting Fellow, National Institute of Health, Laboratory of Cell Biology, Bethesda, MD, USA 1980-1981 Post-doctoral Fellow, Nencki Institute of Experimental Biology PAN, Warsaw 1976-1980 PhD Student, Nencki Institute of Experimental Biology PAN, Warsaw 40 Annual Report 2008 Jacek Kuźnicki PhD, Professor MEMBERSHIP IN SCIENTIFIC SOCIETIES, ORGANIZATIONS AND PANELS • Member of the European Calcium Society Board, since 2008 • Member of Prime Minister Award Committee, 2007 - 2009 • Member of Health Research Advisory Group the 7 th FP European Commission, since 2006 • Member of the Polish Academy of Sciences (PAN), since 2004 • Member of the American Society for Biochemistry and Molecular Biology, since 2003 • Head of the Advisory Board of the Centre for Innovative Bioscience Education (SFN), since 2002 • Member of the Biochemical Society (England), since 1995 • Member of the Polish Neuroscience Society, since 1991 • Member of the Polish Society for the Advancement of Science and Arts, since 1991 • Vice-president of the Polish Biotechnology Committee, 1996-1999 and 2000-2002 • Member of the Polish Biotechnology Committee, 1990-2002 • Co-Editor of Advances in Biochemistry (published in Polish), 1989-1992 • Member of the Polish Biochemical Society, since 1977, General Secretary, 1989-1991 HONORS, PRIZES, AWARDS • Officer’s Cross of the Order of Polonia Restituta awarded by the President of the Republic of Poland, 2008 • Professorial Subsidy Program Award from Foundation for Polish Science (FNP), 2004-2008 • Prime Minister Award for the scientific achievements, 2003 • Award from the Division of Biological Sciences of PAN for the work on calcium binding proteins, 2001 • Knight’s Cross of the Order of Polonia Restituta awarded by the President of the Republic of Poland, 1998 • Polish Anatomical Society Award for the article on calcium binding proteins published in “Advances in Cell Biology”, 1987 • Skarżyński Award from Polish Biochemical Society for the best review article in Advances in Biochemistry, 1986 • Parnas Award from Polish Biochemical Society for the publishing of the best paper in biochemical research, 1977 • Mozołowski Award, Polish Biochemical Society for outstanding Polish young biochemists, 1977 • MSc, Magna cum laude, University of Warsaw, 1976
Publications in 2008 • Bojarski L, Pomorski P, Szybinska A, Drab M, Skibinska- Kijek A, Gruszczynska-Biegala J, Kuznicki J. Presenilindependent expressions of STIM proteins and dysregulation of capacitative Ca(2+) entry in familial Alzheimer’s disease. Biochim Biophys Acta MCR, 2008 Dec 6; [Epub ahead of print] • Klejman ME, Gruszczynska-Biegala J, Skibinska-Kijek A, Wisniewska MB, Misztal K, Blazejczyk M, Bojarski L, Kuznicki J. Expression of STIM1 in brain and puncta-like colocalization of STIM1 and ORAI1 upon depletion of Ca 2+ store in neurons. Neurochem Int, 2009; 54:49-55 • Erickson RP, Larson-Thome K, Weberg L, Szybinska A, Mossakowska M, Styczynska M, Barcikowska M, Kuznicki J. Variation in NPC1, the gene encoding Niemann-Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population. Neurosci Lett, 2008; 447:153–157 • Winiarska M, Bil J, Wilczek E, Wilczynski GM, Lekka M, Engelberts PJ, Mackus WJ, Gorska E, Bojarski L, Stoklosa T, Nowis D, Kurzaj Z, Makowski M, Glodkowska E, Issat T, Mrowka P, Lasek W, Dabrowska-Iwanicka A, Basak GW, Wasik M, Warzocha K, Sinski M, Gaciong Z, Jakobisiak M, Parren PW, Golab J. Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. PLoS Med, 2008; 5:e64 • Mossakowska M, Barcikowska M, Broczek K, Grodzicki T, Klich-Raczka A, Kupisz-Urbanska M, Podsiadly- Moczydlowska T, Sikora E, Szybinska A, Wieczorkowska- Tobis K, Zyczkowska J, Kuznicki J. Polish Centenarians Programme - Multidisciplinary studies of successful ageing: Aims, methods, and preliminary results. Exp Gerontol, 2008; 43:238-244 • Bojarski L, Herms J, Kuznicki J. Calcium dysregulation in Alzheimer’s disease. Neurochem Int, 2008; 52:621-633 • Wojda U, Salinska E, Kuznicki J. Calcium ions in neuronal degeneration. IUBMB Life, 2008; 60:575-590 • Sbroggiò M, Ferretti R, Percivalle E, Gutkowska M, Zylicz A, Michowski W, Kuznicki J, Accornero F, Pacchioni B, Lanfranchi G, Hamm J, Turco E, Silengo L, Tarone G, Brancaccio M. The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1. FEBS Lett, 2008; 582:1788-94 • Lanni C, Racchi M, Mazzini G, Ranzenigo A, Polotti R, Sinforiani E, Olivari L, Barcikowska M, Styczynska M, Kuznicki J, Szybinska A, Govoni S, Memo M, Uberti D. Conformationally altered p53: a novel Alzheimer’s disease marker? Mol Psychiatry, 2008; 13:641-647 • Zabka M, Lesniak W, Prus W, Kuznicki J, Filipek A. Sgt1 has co-chaperone properties and is up-regulated by heat shock. Biochem Biophys Res Commun, 2008; 370:179-183 • Filipek A, Michowski W, Kuznicki J. Involvement of S100A6 (calcyclin) and its binding partners in intracellular signaling pathways. Advan Enzyme Regul, 2008; 48:225-239 • Blazejczyk M, Wojda U. Factfile: Calmyrin 1 (review). Calcium Binding Proteins, 2008; 3:1-3 Current Projects We are interested in molecular mechanisms involved in learning and memory, as well as neurodegeneration; we study these processes at the genomic, proteomic and cellular levels. Our major projects are: 1. Search for bio-markers and potential therapeutic targets for Alzheimer’s disease (AD). 2. Analysis of proteins involved in Ca 2+ homeostasis in neurons and non-neuronal cells. 3. Analysis of Ca 2+ -binding proteins calmyrin1 and calmyrin2 in neurons. 4. Regulation and role of β-catenin/Lef1 complex in mature neurons. 5. Characterization of biological functions of CHORD containing proteins in the nervous system. 6. Studies on the cyclin-dependent kinase 5 involvement in pathogenesis of Alzheimer’s disease. 1. Search for functional bio-markers and potential therapeutic targets of Alzheimer’s disease (Emilia Białopiotrowicz, Łukasz Bojarski, Mirosław Drab, Aleksandra Szybińska, Bożena Kuźniewska, Urszula Wojda, in collaboration with other laboratories) In this area, several projects were carried out: 1.1. In cooperation with Prof. Maurizio Memo and Dr. Daniela Uberti (University of Brescia) the conformational mutant p53 as a new putative marker to discriminate AD from non-AD patients was analyzed. Conformation of p53 protein was studied in cell lysates from our immortalized B lymphocytes from 13 sporadic AD (SAD) and 10 familial AD (FAD) patients and 12 control subjects by immunoprecipitation experiments. Cells from SAD and FAD patients specifically expressed an increased amount of conformationally altered p53 that makes them distinguishable from cells of age-matched non-AD subjects. This suggests a role for a dearrangement of protein controlling the cell cycle in AD pathogenesis (C. Lanni, et al., Mol Psych, 2008). Since p53 conformational tertiary structure is influenced by redox status of the cells, we also evaluated the oxidative profile of these patients. We found that among the markers of oxidative stress, hydroxytransnonenal-modified proteins were significantly increased in FAD patients. Furthermore it is interested to note that, besides increased levels of oxidative markers, the antioxidant defence mechanisms were compromised in these patients. These results supported and enhanced the first evidences of peripheral unfolded p53 associated with AD pathology and highlighted the identification of oxidative stress markers in peripheral, immortalised cells derived from FAD patients. 1.2. It has been suggested that the aberrant expression of cell cycle molecules in the brain contributes to the development of Alzheimer’s disease (AD) and causes neuronal death. The aim of the current study was to determine whether the alterations in cell cycle progression can be observed in lymphocytes from SAD and FAD patients. Immortalized B-lymphocytes from 17 SAD and 6 FAD patients (bearing distinct PS1 mutations) were studied in comparison to lymphocytes from 18 healthy individuals. Laboratory of Neurodegeneration 41
Page 1 and 2: INTERNATIONAL INSTITUTE OF MOLECULA
Page 3 and 4: Contents International Institute of
Page 5 and 6: laboratories were launched: the Lab
Page 7 and 8: International Advisory Board Struct
Page 9 and 10: International Advisory Board of the
Page 11 and 12: Description of the Institute’s Ac
Page 13 and 14: Grants 7 th Framework Programme •
Page 15 and 16: ioinformatics to characterize and d
Page 17 and 18: Scientific Meetings and Lectures
Page 19 and 20: Lab Leaders Competitions The princi
Page 21 and 22: Diversity of Funding IIMCB’2008 A
Page 23 and 24: Department of Molecular Biology Lab
Page 25 and 26: Selected publications • Wawrzynow
Page 27 and 28: Fig. 3. Massive overexpression of H
Page 29 and 30: Laboratory of Bioinformatics and Pr
Page 31 and 32: Publications in 2008 • Orlowski J
Page 33 and 34: cross-linking, mass spectrometry, c
Page 35 and 36: Laboratory of Structural Biology MP
Page 37 and 38: • Filipek R, Potempa J, Bochtler
Page 39 and 40: Fig. 4. Overview of peptidoglycan a
Page 41: Laboratory of Neurodegeneration Lab
Page 45 and 46: Fig. 2. 21 days in vitro hippocampa
Page 47 and 48: involved in defence against pathoge
Page 49 and 50: Laboratory of Biomodelling Lab Lead
Page 51 and 52: • Jozwiak K, Krzysko KA, Bojarski
Page 53 and 54: Fig. 3. Superimposition of EF-hand
Page 55 and 56: Laboratory of Cell Biology Lab Lead
Page 57 and 58: Description of Current Research The
Page 59 and 60: Fig. 2. Endocytosis of transferrin
Page 61 and 62: Laboratory of Molecular and Cellula
Page 63 and 64: • Swiech L, Perycz M, Malik A, Ja
Page 65 and 66: target of rapamycin). mTOR is a ser
Page 67 and 68: Fig. 3: mTOR inhibition impairs mic
Page 69 and 70: Laboratory of Cell Cortex Mechanics
Page 71 and 72: Research The main goal of the group
Page 73 and 74: Fig. 3: Oscillations induced by las
Page 75 and 76: Laboratory of Protein Structure Lab
Page 77 and 78: 1. Integrase superfamily Integrase
Page 79 and 80: Centre for Innovative Bioscience Ed
Page 81 and 82: The Polish Volvox web site (http://
Page 83 and 84: Laboratory of Protein Structure Mar
Page 85 and 86: Centre for Innovative Bioscience Ed
Page 87: International Institute of Molecula

10 A niversary of IIMCB

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