10 A niversary of IIMCB
10 A niversary of IIMCB
10 A niversary of IIMCB
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Matthias Bochtler<br />
PhD, DSc. Habil.<br />
DEGREES<br />
• DSc. Habil, Institute <strong>of</strong> Bioorganic Chemistry PAN, Poznan,<br />
Poland, 2006<br />
• PhD in biochemistry, Technical University <strong>of</strong> Munich,<br />
Germany, 1999<br />
• MSc in experimental physics, Munich University, Germany,<br />
1995<br />
RESEARCH TRAINING<br />
1999-2000 Max Planck Institute <strong>of</strong> Biochemistry, Martinsried,<br />
Germany<br />
1996-1999 Research Assistant, MPI <strong>of</strong> Biochemistry,<br />
Martinsried, Germany<br />
1995-1996 Internship, the Department <strong>of</strong> Medical<br />
Microbiology, University <strong>of</strong> Regensburg,<br />
Germany<br />
1992-1993 Guest Student, Cambridge University, United<br />
Kingdom<br />
1990-1992 Studies in physics, Munich University, Germany<br />
PROFESSIONAL EMPLOyMENT<br />
Since 2007 part time Director <strong>of</strong> Structural Biology, Cardiff<br />
University, United Kingdom<br />
Since 2001 Head <strong>of</strong> the Joint MPG-PAN Junior Group at<br />
the International Institute <strong>of</strong> Molecular and Cell<br />
Biology in Warsaw<br />
2000 Patent training (Weickmann & Weickmann)<br />
1999-2000 Post-doctoral Fellow at the Max Planck Institute<br />
<strong>of</strong> Biochemistry in Martinsried, Germany<br />
HONORS, PRIZES, AWARDS<br />
1. Pienkowski Award, 2005<br />
2. EMBO/HHMI Young Investigator Award, 2004<br />
3. Crystal Award, Germany, 2000<br />
4. Crystal Award, Germany, 1998<br />
5. Scholarship from Deutsche Studienstiftung and the<br />
Bavarian State, 1990-1992<br />
34 Annual Report 2008<br />
Recent publications<br />
Protein-DNA interactions<br />
• Sukackaite R, Grazulis S, Bochtler M, Siksnys V. The<br />
recognition domain <strong>of</strong> the BpuJI restriction endonuclease<br />
in complex with cognate DNA at 1.3-A resolution. J Mol<br />
Biol, 2008;378:<strong>10</strong>84-93<br />
• Szczepanowski RH, Carpenter MA, Czapinska H,<br />
Zaremba M, Tamulaitis G, Siksnys V, Bhagwat AS,<br />
Bochtler M. Central base pair flipping and discrimination<br />
by PspGI. Nucleic Acids Res, 2008; 36:6<strong>10</strong>9-17<br />
• Tamulaitis G, Zaremba M, Szczepanowski RH,<br />
Bochtler M, Siksnys V. How PspGI, catalytic domain <strong>of</strong><br />
EcoRII and Ecl18kI acquire specificities for different DNA<br />
targets. Nucleic Acids Res, 2008; 36:6<strong>10</strong>1-8<br />
• Lipka M, Filipek R, Bochtler M. Crystal structure and<br />
mechanism <strong>of</strong> the Staphylococcus cohnii virginiamycin B<br />
lyase (Vgb). Biochemistry, 2008;47:4257-65<br />
• Tamulaitis G, Zaremba M, Szczepanowski RH,<br />
Bochtler M, Siksnys V. Nucleotide flipping by restriction<br />
enzymes analyzed by 2-aminopurine steady-state<br />
fluorescence. Nucleic Acids Res, 2007; 35:4792-9<br />
• Sokolowska M, Kaus-Drobek M, Czapinska H, Tamulaitis<br />
G, Szczepanowski RH, Urbanke C, Siksnys V, Bochtler M.<br />
Monomeric restriction endonuclease BcnI in the apo form<br />
and in an asymmetric complex with target DNA. J Mol Biol,<br />
2007; 369:722-734<br />
• Kaus-Drobek M, Czapinska H, Sokolowska M,<br />
Tamulaitis G, Szczepanowski RH, Urbanke C, Siksnys V,<br />
Bochtler M. Restriction endonuclease MvaI is a monomer<br />
that recognizes its target sequence asymmetrically.<br />
Nucleic Acids Res, 2007; 35:2035-46<br />
• Bochtler M, Szczepanowski RH, Tamulaitis G, Grazulis<br />
S, Czapinska H, Manakova E, Siksnys V. Nucleotide<br />
flips determine the specificity <strong>of</strong> the Ecl18kI restriction<br />
endonuclease. EMBO J, 2006; 25(<strong>10</strong>):2219-29<br />
Peptidases, proteases and protein degradation<br />
• Groll M, Bochtler M, Brandtstetter H, Clausen T,<br />
Huber R Molecular Machines for Protein Degradation.<br />
ChemBioChem, 2005; 6:222-56<br />
• Szczepanowski RH, Filipek R, Bochtler M. Crystal<br />
Structure <strong>of</strong> a Fragment <strong>of</strong> Mouse Ubiquitin-activating<br />
Enzyme. J Biol Chem, 2005; 280:22006-11<br />
• Odintsov SG, Sabala I, Bourenkov G, Rybin V, Bochtler M.<br />
Staphylococcus aureus aminopeptidase S is a founding<br />
member <strong>of</strong> a new peptidase clan. J Biol Chem, 2005;<br />
280:27792-9<br />
• Odintsov SG, Sabala I, Bourenkov G, Rybin V, Bochtler M.<br />
Substrate access to the active sites in aminopeptidase T, a<br />
representative <strong>of</strong> a new metallopeptidase clan. J Mol Biol,<br />
2005; 354:403-12<br />
• Korza HJ, Bochtler M. Pseudomonas aeruginosa LDcarboxypeptidase,<br />
a serine peptidase with a Ser-His-<br />
Glu triad and a nucleophilic elbow. J Biol Chem, 2005;<br />
280:40802-12<br />
• Firczuk M, Mucha A, Bochtler M. Crystal structures <strong>of</strong><br />
active LytM. J Mol Biol, 2005; 354:578-90