10 A niversary of IIMCB
10 A niversary of IIMCB
10 A niversary of IIMCB
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ioinformatics to characterize and develop models <strong>of</strong><br />
biological processes <strong>of</strong> medical and agricultural interest”:<br />
1) Modeling <strong>of</strong> protein structures and their complexes,<br />
2) A database <strong>of</strong> systems for DNA repair and degradation, 3)<br />
Experimental analyses <strong>of</strong> DNA repair proteins; 340,000PLN;<br />
2006-2009; J.M. Bujnicki<br />
• “From patterns <strong>of</strong> gene expression and regulatory<br />
motifs towards prediction and modeling <strong>of</strong> global<br />
gene expression in brain physiology and pathology”,<br />
Director: B. Kamińska-Kaczmarek from Nencki Institute <strong>of</strong><br />
Experimental Biology; within the commissioned grant:<br />
„Application <strong>of</strong> functional genomics and bioinformatics for<br />
characterization and modeling <strong>of</strong> biological processes <strong>of</strong><br />
critical importance for medicine and agriculture” (3/0-PBZ-<br />
MNiI-2/1/2005); 375,000 PLN; 2006-2009; J. Jaworski<br />
• “Search for diagnostic methods <strong>of</strong> Alzheimer disease and<br />
identification <strong>of</strong> pathogenic mechanisms as potential<br />
targets <strong>of</strong> therapies based on proteomic research in<br />
human lymphocytes” (K129/P05/2005/UMED6); 400,000<br />
PLN; 2005-2008; U. Wojda (within commissioned grant PBZ-<br />
KBN-124/P05/2004 directed by Medical University <strong>of</strong> Lodz);<br />
Director: P. Liberski<br />
Other Research Grants<br />
• Scientific Network “Visualization <strong>of</strong> biomedical<br />
phenomena” – BIOWIZJA coordinated by the Institute <strong>of</strong><br />
Fundamental Technological Research (63/E-89/BWSN-<br />
0142/2008); 200,000 PLN; J. Bujnicki/M. Nowotny<br />
• Scientific Network “Mechanisms <strong>of</strong> cellular movements<br />
– Mobilitas.pl” coordinated by the Nencki Institute <strong>of</strong><br />
Experimental Biology PAN (2/E-36/SN-0075/2007); 75,000<br />
PLN; 2007-2008; M. Miączyńska<br />
• Scientific Network organized by Institute <strong>of</strong> Pharmacology<br />
PAN – “Looking for systemic targets <strong>of</strong> potential<br />
neurotrophic drugs” (26/E-40/BWSN-0023/2008); 54,680<br />
PLN; J. Kuźnicki/M. Wiśniewska<br />
• Grant from Foundation for Polish Science (Homing<br />
Programme) “Post-translational modifications and<br />
nuclear functions <strong>of</strong> endosomal APPL proteins” (HOM/<br />
ed2007/126); 80,000 PLN; 2007-2009; I. Pilecka<br />
• Pr<strong>of</strong>essorial Grant from Foundation for Polish Science<br />
(SP<strong>10</strong>/04) “Beta-catenin metabolism in health and disease”;<br />
240,000 PLN; 2004-2008; J. Kuźnicki<br />
Publications resulting from grants (not affiliated<br />
to <strong>IIMCB</strong> research groups)<br />
1. Mossakowska M, Pawlinska-Chmara R, Broczek KM.<br />
Asthma, allergy, and respiratory symptoms in centenarians<br />
living in Poland. J Physiol Pharmacol. 2008; 56 Suppl<br />
6:483-489<br />
2. Geremek M, Schoenmaker F, Zietkiewicz E, Pogorzelski<br />
A, Diehl S, Wijmenga C, Witt M. Sequence analysis <strong>of</strong><br />
21 genes located in the Kartagener syndrome linkage<br />
region on chromosome 15q. Eur J Hum Genet, 2008;<br />
16:688-695<br />
3. Dawidowska M, Jółkowska J, Szczepański T, Derwich K,<br />
Wachowiak J, Witt M. Implementation <strong>of</strong> the standard<br />
strategy for identification <strong>of</strong> Ig/TCR targets for minimal<br />
residual disease diagnostics in B-cell precursor ALL<br />
pediatric patients: Polish experience. Arch Immunol Ther<br />
Exp, 2008; 56:409-418<br />
4. Loges NT, Olbrich H, Fenske L, Mussaffi H, Horvath J,<br />
Fliegauf M, Kuhl H, Baktai G, Peterffy E, Chodhari R, Chung<br />
EM, Rutman A, O’Callaghan C, Blau H, Tiszlavicz L, Voelkel<br />
K, Witt M, Zietkiewicz E, Neesen J, Reinhardt R, Mitchison<br />
HM, Omran H. DNAI2 mutations cause primary ciliary<br />
dyskinesia with defects in the outer dynein arm. Am J<br />
Hum Genet, 2008; 83:547-558<br />
Scientific degrees in 2008<br />
Academic Habilitation:<br />
• Marta Miączyńska, habilitation thesis: „Effector proteins<br />
<strong>of</strong> Rab5 GTPase in the regulation <strong>of</strong> endocytosis and signal<br />
transduction”, Nencki Institute <strong>of</strong> Experimental Biology<br />
PAN, Warsaw, 27.06.2008<br />
• Paweł Bieganowski, habilitation thesis: „New<br />
developments in biosynthesis <strong>of</strong> NAD and NADP”, Institute<br />
<strong>of</strong> Bioorganic Chemistry PAN, Poznań, 4.11.2008<br />
PhD:<br />
• Magdalena Błażejczyk, PhD thesis: „Neuronal<br />
characterization <strong>of</strong> two calcium binding proteins,<br />
calmyrin 1 and calmyrin 2 belonging to „EF-hand”<br />
superfamily”, Mentor: U. Wojda, Nencki Institute <strong>of</strong><br />
Experimental Biology PAN, Warsaw, 20.02.2008<br />
• Walerych Dawid, PhD thesis: „Rescue <strong>of</strong> human p53<br />
activity by molecular chaperones”, Mentor: A. Żylicz,<br />
Institute <strong>of</strong> Biochemistry and Biophysics PAN, Warsaw,<br />
6.05.2008<br />
• Aleksandra Helwak, PhD thesis: „Comparative analysis<br />
<strong>of</strong> the Hsc70 and Hsp70 molecular chaperones”, Mentor:<br />
M. Żylicz, Nencki Institute <strong>of</strong> Experimental Biology PAN,<br />
Warsaw, 27.05.2008<br />
• Małgorzata Gutkowska, PhD thesis: „Human Hsp90,<br />
its is<strong>of</strong>orms and postulated mechanism <strong>of</strong> function”,<br />
Mentor: A. Żylicz, Nencki Institute <strong>of</strong> Experimental<br />
Biology PAN, Warsaw, 29.09.2008<br />
• Adam Sobczak, PhD thesis: „ Identification and<br />
characterisation <strong>of</strong> interction between Calmyrin 1 -<br />
calcium binding protei, and SCG<strong>10</strong> - tubulin cytoskeleton<br />
regulator in neuronal cells”, Mentor: U. Wojda, Nencki<br />
Institute <strong>of</strong> Experimental Biology PAN, Warsaw, 4.11.2008<br />
• Leszek Lipiński, PhD thesis: „Functional analysis <strong>of</strong><br />
serine-threonine protein kinase TSSK3”, Mentor: M. Żylicz,<br />
Institute <strong>of</strong> Biochemistry and Biophysics PAN, Warsaw,<br />
25.11.2008<br />
• Łukasz Bojarski, PhD thesis: „Presenilin 1 related<br />
deregulation <strong>of</strong> cellular calcium homeostasis in<br />
Alzheimer’s disease”, Mentor: J. Kuźnicki, Nencki Institute<br />
<strong>of</strong> Experimental Biology PAN, Warsaw, 9.12.2008<br />
Annual Report 2008 13