ABSTRACTS – ORAL PRESENTATIONS - AMCA, spol. s r.o.

Acknowledgements
This work was supported by the Slovak Research and Development Agency (APVV
0669-10) and the VEGA Grant Agency (2/0150/11) of the Slovak Republic.
References
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Legend to figure
Fig. 1. Immunophenotype of patient with acute B-lymphoblastic leukemia, CD34 +high
immunophenotype. Parameter CD45 shows gated neutrophils (Neu), monocytes (Mo),
lymphocytes (Ly) and pathologic cells (Pat).
P78. THE DISTRIBUTION OF PROFLAVINE DERIVATIVES IN LEUKEMIA CELLS
Zuzana Ipothova 1 , Luba Hunakova 2 , Helena Paulikova 3 , Lydia Cizekova 3
1
Department of Chemical and Biochemical Engineering, Faculty of Chemical and Food
Technology, Slovak University of Technology in Bratislava, Slovak Republic;
zuzana.ipothova@gmail.com
2
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovak Republic
3
Department of Biochemistry and Microbiology, Faculty of Chemical and Food
Technology, Slovak University of Technology in Bratislava, Slovak Republic
In last two decades, new acridine derivatives have been intensively studied as novel
antitumor drug candidates which are able to intercalate into DNA and interact with
nuclear topoisomerase and telomerase enzymes (Cholewinski et al., 2011). Besides
accumulation in the cell nucleus, the acridine derivatives showed also an atypical
subcellular localization in mitochondria and lysosomes (Peixoto et al., 2009). Recently,
cytotoxicity of novel acridine derivatives, 3,6-bis((1-alkyl-5-oxo-imidazolidin-2-yliden)
imino)acridine hydrochlorides (AcrDIMs), has been confirmed for leukemic cell lines
(Janovec et al., 2011). These derivatives with different side alkyl chain (C2 –C6) showed
182 Analytical Cytometry VII