ABSTRACTS â ORAL PRESENTATIONS - AMCA, spol. s r.o.

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significance (5.3 vs. 2.6 %). On the other hand, percentage of mature B lymphocytes was significantly decreased in MGUS when compared with MM (62.7 vs. 83.8 %; p
cells (SFC) using IFN-γ Elispot in comparison to controls. Moreover, a trend to higher numbers of SFC was observed in these patients when compared to persons with a low frequency of recurrences (n=7). Additionally, lack of difference was found in CD38 and HLA-DR expression on circulating CD8+ T cells between the study groups. Overall, these results indicate that systemic HSV-specific T cells are not suppressed during recurrent genital herpes and the increased frequencies of these cells in the blood are associated with the disease severity rather than with a protective role of these cells. Acknowledgements This work was supported by the grant of Charles University in Prague, PRVOUK/P24/LF1/3. References Wald A, Zeh J, Selke S, et al. Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. N Engl J Med 2000;342:844-50. Zhu J, Koelle DM, Cao J, et al. Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation. J Exp Med 2007;204:595-603. P56. REDUCED ALLERGY INCIDENCE AND INCREASED ACTIVITY OF TREGS IN SIX YEAR OLD CHILDREN OF ALLERGIC MOTHERS COLONIZED AT BIRTH BY PROBIOTIC E. COLI Jiří Hrdý 1 , Ingrid Kocourková 2 , Rája Lodinová-Žádníková 2 , Ludmila Prokešová 1 1 Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic; jiri.hrdy@lf1.cuni.cz 2 Institute for the Care of Mother and Child, Prague, Czech Republic Allergy belongs to one of the most common diseases with still increasing incidence. In our previous work, we reported decreased allergy incidence in probiotic (Colinfant New Born, Escherichia coli O83:K24:H31) colonized children [Lodinová-Žádníková, 2003, Lodinová-Žádníková, 2010]. In this work, significantly decreased allergy incidence in colonized children of allergic mothers (children with high risk for allergy development) in comparison to noncolonized children of allergic mothers was observed. Allergy incidence in colonized children of allergic mothers was comparable with allergy incidence in non-colonized children of healthy mothers (children with relatively low risk for allergy development). The beneficial effect of probiotics is well acknowledged but the mechanisms of their actions are still unclear. Because regulatory T cells (Tregs) are known to set the tolerance to relatively innocuous environmental antigens (allergens), the proportion and functional properties of Tregs from peripheral blood of colonized and non-colonized children in relation to their allergy status were followed by flow cytometry. Surface markers of Tregs, intracellular FoxP3 and regulatory cytokines IL-10 and TGF-beta were tested. The Treg percentage was lower in the blood of healthy children but the MFI (median of fluorescence intensity) of FoxP3 reflecting better the functional potency was higher in Tregs of healthy children in comparison with allergic ones. Furthermore, intracellular presence of IL-10 was detected in higher percentage of Tregs of healthy children in 154 Analytical Cytometry VII
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ABSTRACTS - ORAL PRESENTATIONS 14.
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and (iii) siRNA-mediated knockdown
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25. PROFILING OF CHILDHOOD ACUTE LE
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more dominantly than Th1 and CD4 ce
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29. INFLUENCE OF THE LEVEL OF CD133
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36. B-CELL IMMUNOPHENOTYPING OF LAR
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possible mechanism behind risk alle
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isotype controls and FMO for CD14 a
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NEP developmental stages were disti
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50. THE PROGRESSION OF HIV INFECTIO
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52. PRŮKAZ REGULAČNÍCH T LYMFOCY
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values when analysing paediatric ly
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42,0) vs. 1,5 (0,0-28), p
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for application of proton therapy,
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effects will be also characterized
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Although multiple signalling pathwa
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an ability to recreate the tumour f
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incubated with non-filtered superna
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approaches how to detect and isolat
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progress in development of automate
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tissues is characteristic for a num
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kappaB. Beside that, we found OANO
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therapy in patients (Calderwood et
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difference in the effect caused eit
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4 CIC bioGUNE Technology Park of Bi
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P8. PROADIFEN (SKF-525A) ATTENUATES
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models. As manifested by compromise
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P11. NEW BIOACTIVE AND FLUORESCENT
Page 57 and 58: Acetylation of histones, along with
Page 59 and 60: stimulated cells. The physiological
Page 61 and 62: h induced very minor manifestations
Page 63 and 64: chemotherapeutic drug LA-12. These
Page 65 and 66: aberrant expression, localization a
Page 67 and 68: P21. ASSESSMENT OF MITOCHONDRIAL FU
Page 69 and 70: P23. PTEROSTILBENE: COMPARISON OF A
Page 71 and 72: Fam123b. Amer1 has been shown very
Page 73 and 74: In summary, we described different
Page 75 and 76: this process. Combined treatment wi
Page 77 and 78: Homolog 1) gene; previously identif
Page 79 and 80: egulate expression of different gen
Page 81 and 82: was harmful neither alone nor in co
Page 83 and 84: P34. PHARMACOLOGICAL INHIBITION OF
Page 85 and 86: novel chemotherapeutics with specif
Page 87 and 88: P38. EVIDENCE OF ABNORMAL PERIPHERA
Page 89 and 90: acid to 5-lipoxygenase. Similarly t
Page 91 and 92: P41. WHY CAN WE SEE DIFFERENT RADIO
Page 93 and 94: P42. ELUCIDATION OF CROSSTALK BETWE
Page 95 and 96: P44. INSTRUMENT SETTINGS FOR EUROFL
Page 97 and 98: e used to cultivate endothelial cel
Page 99 and 100: concentrations 0.15, 0.2, 0.3 and 0
Page 101 and 102: P49. NEW ANALOGS OF RHODAMINE Jiři
Page 103 and 104: P51. FLUORESCENCE-LABELED FERROMAGN
Page 105 and 106: could be achieved via the activatio
Page 107: 28. Pp. 1565-1570. 2008. Dearden C:
Page 111 and 112: FACSCantoII flow cytometer (Becton
Page 113 and 114: P59. EARLY DIAGNOSTICS OF CARTILAGE
Page 115 and 116: cross-reacting group (CREG) and sha
Page 117 and 118: the frequency of autoimmune disease
Page 119 and 120: non-covalent bonds. For a solution
Page 121 and 122: P65. OVULATION STIMULATION PROTOCOL
Page 123 and 124: Acknowledgements This work was supp
Page 125 and 126: P68. SUBPOPULATIONS OF B LYMPHOCYTE
Page 127 and 128: triggers a process of normal blood
Page 129 and 130: 3 Department of Internal Medicine -
Page 131 and 132: P73. THE V-ATPASE-INHIBITOR BAFILOM
Page 133 and 134: P75. 5-FLUOROURACIL-SELECTED TUMOUR
Page 135 and 136: We conclude that decrease in the po
Page 137 and 138: Acknowledgements This work was supp
Page 139 and 140: P79. NEW TYPE OF PHOTOSENSITIZER IS
Page 141 and 142: LD11015, from GAČR 13-29358S, and
Page 143 and 144: P83. DIFFERENTIATION OF NEURAL CRES
Page 145 and 146: given cell type are missing and the
Page 147 and 148: and HistoPARK (CZ.1.07/2.3.00/20.01
Page 149 and 150: Our results show that both p38α +/
Page 151 and 152: P90. TOLL-LIKE RECEPTOR 2 TRACKS TH
Page 153 and 154: for chemokines in attracting “inf
Page 155: in immune organs (Bursa of Fabricii
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ABSTRACTS â ORAL PRESENTATIONS - AMCA, spol. s r.o.