CHEM 3511 “Foundations of Bioorganic Chemistry” Tentative ...
CHEM 3511 “Foundations of Bioorganic Chemistry” Tentative ...
CHEM 3511 “Foundations of Bioorganic Chemistry” Tentative ...
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<strong>CHEM</strong> <strong>3511</strong> <strong>“Foundations</strong> <strong>of</strong> <strong>Bioorganic</strong> <strong>Chemistry”</strong><br />
<strong>Tentative</strong> Schedule (Spring 2010)<br />
Instructor: Daniel L. Baker<br />
Contact: SM 423, 678-4178, dlbaker@memphis.edu<br />
Textbook: “Lehninger: Principles <strong>of</strong> Biochemistry”, 5 th edition<br />
Online Homework: saplinglearning.com<br />
Date<br />
Topic(s)<br />
1/14/2010<br />
Overview <strong>of</strong> course structure, exam structure and dates, explain <strong>of</strong> on-line<br />
homework, discuss material that is assumed knowledge<br />
1/19/2010<br />
Lipids (fatty acids, ester bonds, fats and oils, cis-trans double bonds)<br />
Lehninger 5 th edition, chapter 10, pages 343-349<br />
1/21/2010<br />
Lipids (phospholipids, sphingolipids, signaling molecules)<br />
Lehninger 5 th edition, chapter 10, pages 349-359<br />
1/26/2010<br />
Lipids (steroids, lipid soluble vitamins, antixoidants, lipid oxidation)<br />
Lehninger 5 th edition, chapter 10, pages 359-363<br />
1/28/2010 Exam #1 (covers assumed knowledge and lipids)<br />
Carbohydrates (monosaccharides, aldose/ ketose, Fisher projections, epimers,<br />
2/02/2010 anomers, pyranoses/ furanoses)<br />
Lehninger 5 th edition, chapter 7, pages 235-239<br />
2/04/2010<br />
Carbohydrates (monosaccharides, Hayworth projections, pyranose conformations)<br />
Lehninger 5 th edition, chapter 7, pages 239-242<br />
2/09/2010<br />
Carbohydrates (disaccharides, glycosidic bonds, reducing/ nonreducing sugars)<br />
Lehninger 5 th edition, chapter 7, pages 242-244<br />
Carbohydrates (polysaccharides, starch, glycogen, dextran, chitin, biomedical<br />
2/11/2010 processes)<br />
Lehninger 5 th edition, chapter 7, pages 244-263<br />
2/16/2010 Exam #2 (comprehensive through carbohydrates)<br />
Nucleic acids (purines, pyrimidines, nucleotides, nucleosides, ribose, deoyribose,<br />
2/18/2010 phosphodiester bonds)<br />
Lehninger 5 th edition, chapter 8, pages 271-277<br />
2/23/2010<br />
Nucleic acids (base pairing, 3D structure(s), mutations, Sanger sequencing)<br />
Lehninger 5 th edition, chapter 8, pages 277-294<br />
2/25/2010<br />
Nucleic acids (phosphoramidite synthesis, energy stores)<br />
Lehninger 5 th edition, chapter 8, pages 295-298<br />
3/02/2010<br />
Nucleic acids (cloning, pcr)<br />
Lehninger 5 th edition, chapter 9, pages 303-324<br />
3/04/2010 Exam #3 (comprehensive through nucleic acids)<br />
3/09/2010 Spring break<br />
3/11/2010 Spring break<br />
3/16/2010<br />
Proteins (amino acids, stereochemistry, acid/base properties)<br />
Lehninger 5 th edition, chapter 3, pages 71-84<br />
3/18/2010 Proteins (physical properties, chromatography)
Lehninger 5 th edition, chapter 3, pages 85-92<br />
Proteins (primary structure, protein sequencing- Sanger and MS, chemical<br />
3/23/2010 synthesis)<br />
Lehninger 5 th edition, chapter 3, pages 92-107<br />
Proteins (peptide bond, Ramachandran plot, secondary structure, α-helix, β-sheet,<br />
3/25/2010 β-turn, CD)<br />
Lehninger 5 th edition, chapter 4, pages 113-122<br />
Proteins (tertiary and quaternary structure, PDB, x-ray diffraction, NMR, motifs,<br />
3/30/2010 denaturation)<br />
Lehninger 5 th edition, chapter 4, pages 123-148<br />
4/01/2010 Exam #4 (comprehensive through proteins)<br />
Enzymes (thermodynamics, general acid-base, covalent, and metal ion catalysis)<br />
4/06/2010<br />
Lehninger 5 th edition, chapter 6, pages 183-194<br />
Enzymes (kinetics, Michaelis-Menten, Lineweaver-Burk, k cat , enzyme mechanism,<br />
4/08/2010 inhibition mechanism)<br />
Lehninger 5 th edition, chapter 6, pages 194-205<br />
Enzymes (chymotrypsin, hexokinase, enolase, lysozyme, β-lactamase)<br />
4/13/2010<br />
Lehninger 5 th edition, chapter 6, pages 205-220<br />
Enzymes (regulatory enzymes, feedback inhibition, non-Michaelis-Menten,<br />
4/15/2010 phosphorylation, proenzymes)<br />
Lehninger 5 th edition, chapter 6, pages 220-228<br />
4/20/2010 Exam #5 (comprehensive through enzymes)<br />
Bioenergetics<br />
4/22/2010<br />
Lehninger 5 th edition, chapter 13, pages 489-521<br />
Bioenergetics<br />
4/27/2010<br />
Lehninger 5 th edition, chapter 13, pages 489-521<br />
5/04/2010 Final exam (section 1, AM) 10:30 AM -12:30 PM in SM 304<br />
5/06/2010 Final exam (section 2, PM) 5:30 PM -7:30 PM in SM 304
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