QSAR in Development of Antidepressants
QSAR in Development of Antidepressants
QSAR in Development of Antidepressants
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Lead concept<br />
IC 50<br />
(nM)<br />
Drug<br />
TCAs<br />
imipram<strong>in</strong>e<br />
nortriptyl<strong>in</strong>e<br />
protriptyl<strong>in</strong>e<br />
trimipram<strong>in</strong>e<br />
Second generation<br />
Amoxap<strong>in</strong>e<br />
mirtazap<strong>in</strong>e<br />
venlafaz<strong>in</strong>e<br />
fluoxet<strong>in</strong>e<br />
fluvoxam<strong>in</strong>e<br />
paroxet<strong>in</strong>e<br />
sertal<strong>in</strong>e<br />
Norep<strong>in</strong>ephr<strong>in</strong>e<br />
25<br />
6<br />
10<br />
5000<br />
25<br />
40<br />
300<br />
200<br />
500<br />
70<br />
300<br />
5-HT<br />
50<br />
200<br />
250<br />
10000<br />
600<br />
20000<br />
50<br />
15<br />
5<br />
1<br />
4