QSAR in Development of Antidepressants
QSAR in Development of Antidepressants
QSAR in Development of Antidepressants
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GFA<br />
• Statistical analysis method<br />
– Generates multiple <strong>QSAR</strong> models<br />
• Scans for most efficient <strong>QSAR</strong> equation<br />
• Incorporates genetic algorithm<br />
• Models created and screened dur<strong>in</strong>g evolution<br />
– <strong>QSAR</strong> randomly constructed<br />
– Population<br />
• repeatedly select<strong>in</strong>g parent models<br />
• creat<strong>in</strong>g child model<br />
Rogers, D. Relationship. Journal <strong>of</strong> Chemical Information and Computational Science 1994,<br />
34, 854-866.
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