FERRONYL® IRON

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Physical & Chemical Properties Stability Ferronyl iron is stable without loss of efficacy, even under elevated temperature and humidity. When Ferronyl iron was formulated with Vitamin C (50:50 blend) and held in a humidity chamber for several weeks, only slight color changes were noted. This is the result of the Ferronyl carbonyl iron being relatively impervious to atmospheric oxidation. In contrast to other iron sources, such as ferrous salts, Ferronyl iron shows significantly less color change at elevated temperature and humidity (Table 2). Table 2. Ferronyl iron, in combination with Vitamin C, shows minimal color change under elevated temperature and humidity. Iron Source Ambient Elevated Temperature (45 o C) Elevated Temperature and Relative Humidity (45 o C and 75% RH) Week 1 Week 2 Week 3 Week 1 Week 2 Week 3 Week 1 Week 2 Week 3 Ferronyl Iron OK OK OK OK OK OK OK Very slightly off color Slightly off color Ferrous Fumarate OK OK OK OK OK OK Slightly off color Dark Very Dark Brown Ferrous Sulfate OK OK OK OK Slightly off color Off color OK Slightly off color Off color Ferrous Gluconate OK Slightly off color Off color OK Slightly off color Off color OK Slightly off color Black 6
Bioavailability The amount of iron absorbed by the body per unit dosage from a particular iron source is a function of several factors - particle size, surface area, ionic charge, iron content. The first three of these factors contribute to the relative biological value (RBV) of the iron source - a measure of how quickly the iron enters the blood stream. The iron content is a function of molecular structure, i.e., elemental iron versus ferrous salts like ferrous sulfate (FeSO 4 ) and is a measure of the percentage of iron in a unit dose. Multiplying the RBV by the iron content produces the iron absorption per unit dosage. Table 3 shows that the high iron absorption from Ferronyl iron results from its small particle size, which contributes to a higher RBV than other forms of elemental iron, and its high iron content relative to ferrous sulfate. Table 3. The small particle size of Ferronyl iron contributes to its high RBV, which together with its high iron content leads to high absorption per unit dose. Iron Source Particle Size, µm RBV, % Iron Content, % Absorption, % FeSO 4 * N/A 100 20 20 Reduced Iron 10 - 20 34 96 33 Electrolytic Iron 10 - 20 48 97 47 Ferronyl iron 7 - 9 70 98 69 *FeSO 4 ● 4H 2 O In a study of iron-deficient rats, Sacks and Houchin (1978 a,b) concluded that, for similar iron dosage levels, carbonyl iron powder was as effective as ferrous sulfate and more so than ferrous pyrophosphate in restoring normal hematocrit levels (Table 4). Due to its finer particle size, carbonyl iron powder was also found to be more efficacious than the other forms of elemental iron (e.g., electrolytic and reduced). Table 4. Effect of various iron supplements on rat hematocrit levels. Iron Source Supplement Dose (mg/kg) Iron Dose (mg/kg) Increase in Hematocrit with 2 weeks Supplementation Control (Basal Diet) 0 0 -2 FeSO 4 30 6 4 FeSO 4 60 12 11 FeSO 4 120 24 22 CIP 12 12 6 CIP 24 24 15 A Better Choice 7
Page 1 and 2: FERRONYL® IRON Dietary Iron Supple
Page 3 and 4: Introduction Iron deficiency contin
Page 5: Physical & Chemical Properties Part
Page 9 and 10: Applications Liquid Suspensions For
Page 11 and 12: Safety & Toxicity Summary Animal To
Page 13 and 14: Safety & Toxicity Summary Plasma ir
Page 15 and 16: Summary Each year accidental iron o

FERRONYL® IRON

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