FERRONYL® IRON

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Regulatory Ferronyl iron is an elemental iron that is generally recognized as safe (GRAS) under title 21 Code of Federal Regulations, Parts: 184.1375 - Nutrient for human consumption 582.5375 - Nutrient and/or dietary supplement in animal feed Ferronyl iron meets the US Food Chemical Codex specifications for Iron, carbonyl. 14
Summary Each year accidental iron overdose accounts for a significant number of emergency room visits and too many cases of childhood death. In developing effective products for iron supplementation, care must be taken not to increase the incidences of toxic exposure. Ferronyl carbonyl iron powder represents an opportunity to correct a fundamental problem with iron supplementation - the toxicity of currently used iron salts. Ferronyl is far less toxic than soluble iron salts, it causes fewer side effects, and the slow absorption from the GI tract provides time for clinical intervention in the event of accidental overdose. Combined with its high bioavailability, lower use levels and bland taste, Ferronyl iron is a better choice for iron supplementation. References Boyd & Shanas, The Acute Oral Toxicity of Reduced Iron, Canad. Med. Assn. J. 89, 171-175, 1963. Crosby, W. H., Prescribing Iron? Think Safety. Arch. Intern. Med., 138, 766-767, 1978. GAF, Acute Oral Toxicity in the Dog: Carbonyl Iron vs. Ferrous Sulfate, GAF Unpublished data, 1990. ISP, Single Dose Oral Toxicity in Rats / LD50 in Rats; Carbonyl Iron Powder, ISP Unpublished data, 1997a. ISP, Single Dose Oral Toxicity in Rats / LD50 in Rats; Ferrous Sulfate (Iron II) Sulfate, ISP Unpublished data, 1997b. ISP, Single Dose (LD90) Oral Toxicity in Rats; Carbonyl Iron Powder and Ferrous Sulfate (Iron II) Sulfate, ISP Unpublished data, 1997c. ISP, Food Additive Safety Study with Carbonyl Iron and Ferrous Sulfate in Young Swine, ISP Unpublished data, 1998. Sacks, P. V. and D. N. Houchin, Comparative Bioavailability of Elemental Iron Powders for Repair of Iron Deficiency Anemia in Rats. Studies of Efficacy and Toxicity of Carbonyl Iron, Am. Jrnl. Clin. Nutrition, 31(4), 566-571, 1978a. Sacks, P. V. and D. N. Houchin, Elemental Iron Powders for Food Enrichment. Acid Solubility as a Predictor of Bioavailability, Am. Jrnl. Clin. Nutrition, 31(4), 571-576, 1978b. Shelanski, H. A. Acute and Chronic Toxicity Tests on Carbonyl Iron Powder, GAF Unpublished data, 1950. A Better Choice 15
Page 1 and 2: FERRONYL® IRON Dietary Iron Supple
Page 3 and 4: Introduction Iron deficiency contin
Page 5 and 6: Physical & Chemical Properties Part
Page 7 and 8: Bioavailability The amount of iron
Page 9 and 10: Applications Liquid Suspensions For
Page 11 and 12: Safety & Toxicity Summary Animal To
Page 13: Safety & Toxicity Summary Plasma ir

FERRONYL® IRON

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