DNA Microarray Image Analysis - University of Illinois at Urbana ...
DNA Microarray Image Analysis - University of Illinois at Urbana ...
DNA Microarray Image Analysis - University of Illinois at Urbana ...
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Normaliz<strong>at</strong>ion<br />
• Normaliz<strong>at</strong>ion using St<strong>at</strong>istical Descriptors<br />
— Z-Transform<strong>at</strong>ion<br />
I<br />
NORM STAT<br />
Z −TRANSFORM<br />
( row, col)<br />
=<br />
Irowcol ( , ) − µ<br />
σ<br />
— Background Correction<br />
des<br />
⎛ X − X ⎞<br />
= ⎜ ⎟<br />
⎝<br />
⎠<br />
CHANNEL 0 CHANNEL 0<br />
X WRT BKG FRG BKG<br />
LOG RATIO<br />
log 2 CHANNEL1 CHANNEL1<br />
XFRG<br />
− XBKG<br />
81
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